AAA domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004426 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 14Note: Hover over icons to view figure legend
Homology
BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A2L2YU97 (Uncharacterized protein (Fragment) OS=Parasteatoda tepidariorum OX=114398 PE=2 SV=1) HSP 1 Score: 76.2554 bits (186), Expect = 6.617e-14 Identity = 46/117 (39.32%), Postives = 66/117 (56.41%), Query Frame = 2 Query: 119 IVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKGTVIE 469 I GP+GSGK+ FV KL+++N+F I + +G Q F K+KN+K +G N SS VIIIDDL E + + +NL +K + H +T+IF+ QN F KG V+ Sbjct: 7 ISGPTGSGKSFFVSKLIENNMFYPMPKNIIY------CYGCYQPLFDKMKNVKFEEGLPSNLSSI--SDAVIIIDDLMSELSSDITLSNLFSKYSHHRKLTIIFLVQNIFHKGRVMR 115
BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A4Y2QW74 (Uncharacterized protein OS=Araneus ventricosus OX=182803 GN=AVEN_149572_1 PE=4 SV=1) HSP 1 Score: 69.707 bits (169), Expect = 2.190e-11 Identity = 45/113 (39.82%), Postives = 60/113 (53.10%), Query Frame = 2 Query: 119 IVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 I GPS SGKT FV +LL S L Q KI W GA Q F + N++ +G + + +IIIDDL E + +K +NL TK + H +++IFI QN F KG Sbjct: 14 ISGPSNSGKTFFVKRLLDSKLIQPFPPKILWCYGA------YQKLFDNMPNVEFHEGLPSDIDTV--SDALIIIDDLMSEVSSDKRLSNLFTKGSHHRNLSIIFIVQNMFHKG 118
BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A4Y2X7P9 (Uncharacterized protein OS=Araneus ventricosus OX=182803 GN=AVEN_182928_1 PE=4 SV=1) HSP 1 Score: 66.6254 bits (161), Expect = 6.087e-11 Identity = 40/115 (34.78%), Postives = 59/115 (51.30%), Query Frame = 2 Query: 119 IVGPSGSGKTMFVCKLL--KSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 + GP+G GKT FV LL K +F +KI W +G+ Q + + + V+G + L K + IIDDL +K +L TK + H+ +++IFI QNFF KG Sbjct: 3 MAGPTGCGKTYFVRDLLRYKGKMFSPVPDKIVWF------YGIHQPLYDNIPKVAFVEGLPLKFQEYLGKRTLFIIDDLMSHGANQKLLTDLFTKGSHHLNLSIIFIVQNFFHKG 111
BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A443SPL1 (Uncharacterized protein OS=Leptotrombidium deliense OX=299467 GN=B4U80_09714 PE=4 SV=1) HSP 1 Score: 58.9214 bits (141), Expect = 2.392e-10 Identity = 39/115 (33.91%), Postives = 61/115 (53.04%), Query Frame = 2 Query: 119 IVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNW--SSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 + GP+ GKT +V KLLK+ L + ++ +Y++ + L + +K VK D+N + K VI+IDDL EA + +L TK + H ++VI + QNFF KG Sbjct: 10 VAGPTSCGKTAWVMKLLKNMLEKNRYKIVYFY---SMKQPLYDEISASHPFIKFVKNIDQNIIENHNPCKKAVIVIDDLMSEATNNQYICDLFTKGSHHKNLSVILLLQNFFCKG 121 HSP 2 Score: 33.8834 bits (76), Expect = 2.392e-10 Identity = 15/26 (57.69%), Postives = 20/26 (76.92%), Query Frame = 1 Query: 442 LFHQGNGHRTRNLNIQYLVIFKNLRD 519 F +GN +RT +LN QY+V+FKN RD Sbjct: 117 FFCKGNFNRTISLNTQYIVLFKNPRD 142
BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A1I8J8Y3 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 68.9366 bits (167), Expect = 2.706e-10 Identity = 38/127 (29.92%), Postives = 67/127 (52.76%), Query Frame = 2 Query: 89 MELRNDAVYQIVGPSGSGKTMFVCKLL--KSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKI--VKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 + LR + + GP+ +GKT FV L+ K LF K ++ W+ +G++Q +L ++ + +GF + + LR D+++ DDL +E + N+ T IA H+ ++ +TQN F KG Sbjct: 99 VRLRQGSCMIVSGPTNAGKTTFVKHLIQYKDVLFDVKPGRVLWY------YGISQAAHSELSSLGVHLQQGFPSSIETALRPNDLVVFDDLIEETSNSAAMRNVFTGIAHHLPCFLVMLTQNVFFKG 219
BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000051837.1 (SMESG000051837.1) HSP 1 Score: 246.514 bits (628), Expect = 2.176e-77 Identity = 116/123 (94.31%), Postives = 120/123 (97.56%), Query Frame = 2 Query: 89 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 M+LRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNL TKI+RH+GVTVIFITQN F +G Sbjct: 1 MDLRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLFTKISRHVGVTVIFITQNLFHQG 123 HSP 2 Score: 52.373 bits (124), Expect = 3.167e-8 Identity = 23/27 (85.19%), Postives = 24/27 (88.89%), Query Frame = 1 Query: 442 LFHQGNGHRTRNLNIQYLVIFKNLRDA 522 LFHQG HRTRNLN+QYLVIFKN RDA Sbjct: 119 LFHQGGAHRTRNLNVQYLVIFKNPRDA 145
BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000065288.1 (SMESG000065288.1) HSP 1 Score: 248.44 bits (633), Expect = 2.082e-76 Identity = 117/123 (95.12%), Postives = 120/123 (97.56%), Query Frame = 2 Query: 89 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNL TKI+RH+GVTVIFITQN F +G Sbjct: 1 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLFTKISRHVGVTVIFITQNLFHQG 123 HSP 2 Score: 52.7582 bits (125), Expect = 3.016e-8 Identity = 23/27 (85.19%), Postives = 24/27 (88.89%), Query Frame = 1 Query: 442 LFHQGNGHRTRNLNIQYLVIFKNLRDA 522 LFHQG HRTRNLN+QYLVIFKN RDA Sbjct: 119 LFHQGGAHRTRNLNVQYLVIFKNPRDA 145
BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000061056.1 (SMESG000061056.1) HSP 1 Score: 248.054 bits (632), Expect = 2.227e-76 Identity = 117/123 (95.12%), Postives = 120/123 (97.56%), Query Frame = 2 Query: 89 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNL TKI+RH+GVTVIFITQN F +G Sbjct: 1 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLFTKISRHVGVTVIFITQNLFHQG 123 HSP 2 Score: 52.373 bits (124), Expect = 3.282e-8 Identity = 23/27 (85.19%), Postives = 24/27 (88.89%), Query Frame = 1 Query: 442 LFHQGNGHRTRNLNIQYLVIFKNLRDA 522 LFHQG HRTRNLN+QYLVIFKN RDA Sbjct: 119 LFHQGGAHRTRNLNVQYLVIFKNPRDA 145
BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000029226.1 (SMESG000029226.1) HSP 1 Score: 246.514 bits (628), Expect = 8.460e-76 Identity = 116/123 (94.31%), Postives = 120/123 (97.56%), Query Frame = 2 Query: 89 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIKG 457 M+LRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNL TKI+RH+GVTVIFITQN F +G Sbjct: 1 MDLRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLFTKISRHVGVTVIFITQNLFHQG 123 HSP 2 Score: 52.373 bits (124), Expect = 3.376e-8 Identity = 23/27 (85.19%), Postives = 24/27 (88.89%), Query Frame = 1 Query: 442 LFHQGNGHRTRNLNIQYLVIFKNLRDA 522 LFHQG HRTRNLN+QYLVIFKN RDA Sbjct: 119 LFHQGGAHRTRNLNVQYLVIFKNPRDA 145
BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000037212.1 (SMESG000037212.1) HSP 1 Score: 242.662 bits (618), Expect = 1.852e-74 Identity = 113/122 (92.62%), Postives = 119/122 (97.54%), Query Frame = 2 Query: 89 MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLITKIARHIGVTVIFITQNFFIK 454 M+ RNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWH+GADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNL TKI+RH+GVTVIFITQ +FI+ Sbjct: 1 MDFRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHKGADEEHGLTQDNFCKLKNMKIVKGFDKNWSSRLRKGDVIIIDDLYQEANKEKDFNNLFTKISRHVGVTVIFITQIYFIR 122 The following BLAST results are available for this feature:
BLAST of AAA domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of AAA domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of AAA domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of AAA domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004426 ID=SMED30004426|Name=AAA domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=522bpback to top protein sequence of SMED30004426-orf-1 >SMED30004426-orf-1 ID=SMED30004426-orf-1|Name=SMED30004426-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=131bp MELRNDAVYQIVGPSGSGKTMFVCKLLKSNLFQTKFNKIYWHRGADEEHGback to top Annotated Terms
The following terms have been associated with this transcript:
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