DENN domain-containing protein 11

Overview
NameDENN domain-containing protein 11
Smed IDSMED30004395
Length (bp)1450
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DENN domain-containing protein 11 (SMED30004395) t-SNE clustered cells

Violin plots show distribution of expression levels for DENN domain-containing protein 11 (SMED30004395) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DENN domain-containing protein 11 (SMED30004395) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DENN domain-containing protein 11 (SMED30004395) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004395

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30004395SMESG000068092.1 dd_Smed_v4_8805_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30004395SMESG000068092.1 dd_Smed_v4_8805_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30004395SMESG000068092.1 dd_Smed_v4_8805_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30004395SMESG000068092.1 dd_Smed_v4_8805_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Human
Match: DENND11 (DENN domain containing 11 [Source:HGNC Symbol;Acc:HGNC:29472])

HSP 1 Score: 219.55 bits (558), Expect = 1.723e-65
Identity = 135/385 (35.06%), Postives = 223/385 (57.92%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK------NNWEE-CVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH ++SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+           + +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+      N  EE   + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FLL LLE YGID++  ID+ CC
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKIQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGSSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEEDYNPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLLDLLEAYGIDVMLVIDNPCC 454
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Human
Match: DENND11 (DENN domain containing 11 [Source:HGNC Symbol;Acc:HGNC:29472])

HSP 1 Score: 219.55 bits (558), Expect = 1.723e-65
Identity = 135/385 (35.06%), Postives = 223/385 (57.92%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK------NNWEE-CVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH ++SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+           + +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+      N  EE   + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FLL LLE YGID++  ID+ CC
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKIQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGSSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEEDYNPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLLDLLEAYGIDVMLVIDNPCC 454
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Human
Match: DENND11 (DENN domain containing 11 [Source:HGNC Symbol;Acc:HGNC:29472])

HSP 1 Score: 202.216 bits (513), Expect = 4.286e-60
Identity = 125/361 (34.63%), Postives = 211/361 (58.45%), Query Frame = 3 
Query:  198 ILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVF---DYERFLTT----FGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK---NNWEEC----VISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            ++EWC+P D++  G+EFK++ SGSH ++SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+       ++   V+      R++      FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+    ++  C     + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FLL LLE YGID++  ID+ CC
Sbjct:    1 MVEWCLPQDIDLEGVEFKSMASGSHKIQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDK----KGVLHAGPGRGSSLPPVYWLPSIHRYMYPEMKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEEDYNPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLLDLLEAYGIDVMLVIDNPCC 350
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Human
Match: DENND11 (DENN domain containing 11 [Source:HGNC Symbol;Acc:HGNC:29472])

HSP 1 Score: 202.216 bits (513), Expect = 4.286e-60
Identity = 125/361 (34.63%), Postives = 211/361 (58.45%), Query Frame = 3 
Query:  198 ILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVF---DYERFLTT----FGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK---NNWEEC----VISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            ++EWC+P D++  G+EFK++ SGSH ++SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+       ++   V+      R++      FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+    ++  C     + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FLL LLE YGID++  ID+ CC
Sbjct:    1 MVEWCLPQDIDLEGVEFKSMASGSHKIQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDK----KGVLHAGPGRGSSLPPVYWLPSIHRYMYPEMKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEEDYNPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLLDLLEAYGIDVMLVIDNPCC 350
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Zebrafish
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:556432])

HSP 1 Score: 236.498 bits (602), Expect = 9.942e-72
Identity = 146/390 (37.44%), Postives = 225/390 (57.69%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQ-------------TIKTKNVIPI-------SIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+                T  + PI        + + + A  +  + RF   FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +    + ++VAC+T++I + KK  YD  I   N++   E+   +   + ++S+D+ K+ KL + RQ        + DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:  111 IVAVFVVTFDTRSGNMIEWCLPHDVNLEGVEFKSMASGSHRISSDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDKKAVLPSGGNGLVTACPTSALAPIVNRCMHPEMKITHPAGCMSQFIRF---FGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGMGVSVPEFRPFFYINVADIPALE---TELSYVACTTEKIFEEKKELYDVYIDNQNVKTHRES---LQPLLRLNSADREKYRKLCEQRQLLLYSQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAVSADPTLTAEHVRAMGLDPQGDRGFLVDLLEIYGIDVMLVIDNPCC 489
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Zebrafish
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:556432])

HSP 1 Score: 236.498 bits (602), Expect = 1.153e-71
Identity = 146/390 (37.44%), Postives = 225/390 (57.69%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQ-------------TIKTKNVIPI-------SIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+                T  + PI        + + + A  +  + RF   FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +    + ++VAC+T++I + KK  YD  I   N++   E+   +   + ++S+D+ K+ KL + RQ        + DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:  111 IVAVFVVTFDTRSGNMIEWCLPHDVNLEGVEFKSMASGSHRISSDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDKKAVLPSGGNGLVTACPTSALAPIVNRCMHPEMKITHPAGCMSQFIRF---FGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGMGVSVPEFRPFFYINVADIPALE---TELSYVACTTEKIFEEKKELYDVYIDNQNVKTHRES---LQPLLRLNSADREKYRKLCEQRQLLLYSQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAVSADPTLTAEHVRAMGLDPQGDRGFLVDLLEIYGIDVMLVIDNPCC 489
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Zebrafish
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:556432])

HSP 1 Score: 236.498 bits (602), Expect = 1.346e-71
Identity = 146/390 (37.44%), Postives = 225/390 (57.69%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQ-------------TIKTKNVIPI-------SIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+                T  + PI        + + + A  +  + RF   FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +    + ++VAC+T++I + KK  YD  I   N++   E+   +   + ++S+D+ K+ KL + RQ        + DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:  111 IVAVFVVTFDTRSGNMIEWCLPHDVNLEGVEFKSMASGSHRISSDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDKKAVLPSGGNGLVTACPTSALAPIVNRCMHPEMKITHPAGCMSQFIRF---FGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGMGVSVPEFRPFFYINVADIPALE---TELSYVACTTEKIFEEKKELYDVYIDNQNVKTHRES---LQPLLRLNSADREKYRKLCEQRQLLLYSQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAVSADPTLTAEHVRAMGLDPQGDRGFLVDLLEIYGIDVMLVIDNPCC 489
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Zebrafish
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:556432])

HSP 1 Score: 182.956 bits (463), Expect = 2.476e-52
Identity = 108/278 (38.85%), Postives = 162/278 (58.27%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQ-------------TIKTKNVIPI-------SIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEA 920
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+                T  + PI        + + + A  +  + RF   FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +    + ++VAC+T++I + KK  YD  I   N++   E+
Sbjct:  111 IVAVFVVTFDTRSGNMIEWCLPHDVNLEGVEFKSMASGSHRISSDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDKKAVLPSGGNGLVTACPTSALAPIVNRCMHPEMKITHPAGCMSQFIRF---FGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGMGVSVPEFRPFFYINVADIPALE---TELSYVACTTEKIFEEKKELYDVYIDNQNVKTHRES 381
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Mouse
Match: E330009J07Rik (RIKEN cDNA E330009J07 gene [Source:MGI Symbol;Acc:MGI:2444256])

HSP 1 Score: 219.935 bits (559), Expect = 8.175e-66
Identity = 133/385 (34.55%), Postives = 222/385 (57.66%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK---NNWEEC----VISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH V+SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+             +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+    ++  C     + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGGSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEGDYSPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLMDLLEAYGIDVMLVIDNPCC 454
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Mouse
Match: E330009J07Rik (RIKEN cDNA E330009J07 gene [Source:MGI Symbol;Acc:MGI:2444256])

HSP 1 Score: 177.563 bits (449), Expect = 2.216e-50
Identity = 100/269 (37.17%), Postives = 159/269 (59.11%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIE 905
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH V+SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+             +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGGSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVK 341
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Mouse
Match: E330009J07Rik (RIKEN cDNA E330009J07 gene [Source:MGI Symbol;Acc:MGI:2444256])

HSP 1 Score: 121.324 bits (303), Expect = 2.001e-32
Identity = 55/106 (51.89%), Postives = 79/106 (74.53%), Query Frame = 3 
Query:  195 NILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQ 512
            N++EWC+P D++  G+EFK++ SGSH V+SDF+YFR+  F+G+ CFA  P++ E  ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+
Sbjct:   19 NMVEWCLPQDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPVESEL-ERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDK 123
[Close]
BLAST of DENN domain-containing protein 11 vs. UniProt/SwissProt
Match: sp|Q1LX49|DEN11_DANRE (DENN domain-containing protein 11 OS=Danio rerio OX=7955 GN=dennd11 PE=3 SV=1)

HSP 1 Score: 236.498 bits (602), Expect = 7.505e-71
Identity = 146/390 (37.44%), Postives = 225/390 (57.69%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQ-------------TIKTKNVIPI-------SIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+                T  + PI        + + + A  +  + RF   FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +    + ++VAC+T++I + KK  YD  I   N++   E+   +   + ++S+D+ K+ KL + RQ        + DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:  111 IVAVFVVTFDTRSGNMIEWCLPHDVNLEGVEFKSMASGSHRISSDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDKKAVLPSGGNGLVTACPTSALAPIVNRCMHPEMKITHPAGCMSQFIRF---FGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGMGVSVPEFRPFFYINVADIPALE---TELSYVACTTEKIFEEKKELYDVYIDNQNVKTHRES---LQPLLRLNSADREKYRKLCEQRQLLLYSQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAVSADPTLTAEHVRAMGLDPQGDRGFLVDLLEIYGIDVMLVIDNPCC 489
[Close]
BLAST of DENN domain-containing protein 11 vs. UniProt/SwissProt
Match: sp|Q4FZX0|DEN11_XENLA (DENN domain-containing protein 11 OS=Xenopus laevis OX=8355 GN=dennd11 PE=2 SV=1)

HSP 1 Score: 230.72 bits (587), Expect = 2.721e-69
Identity = 143/388 (36.86%), Postives = 220/388 (56.70%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVFD------------------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I+AVFVV+FD + GNI+EWC P D++  G+EFK++ SGSH V+SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VG+LS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P+       A +                       +F+  FG +IF LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D +       + ++VAC+T++I + K+  YD  +   N++   E    +   + V+S+DK K+ +L D RQ        + DC     E+  I FF  +NNR+   LL++A+S +  +T      +G  P  D+ FL+ LLE YG DL+  ID+ CC
Sbjct:   58 IAAVFVVTFDPRSGNIVEWCRPHDIDLEGVEFKSMASGSHRVQSDFIYFRKGGFFGLACFANMPV-ESELERGARMKSVGVLSPSYTLLYRYMHFLENQVRHQLEIPGHYTPLEAFYEDK----KGVLPVGPQTCQPALHWLPPVHKHLYPEMKITHPAGCMSQFIKFFGEQIFVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVTLPGIGATAPESKPFFYVNVADIQTLD---GEGSYVACTTEKIFEQKQDLYDVYVDNQNVKTHRE---HLQPLLRVNSADKEKYQRLNDQRQLLMYSQEVDGDCGSCE-EDLFILFFMEQNNRIFQTLLEVASSQDKTLTAEHARSMGLDPHGDRTFLMDLLEVYGFDLMLVIDNPCC 433
[Close]
BLAST of DENN domain-containing protein 11 vs. UniProt/SwissProt
Match: sp|Q3UHG7|DEN11_MOUSE (DENN domain-containing protein 11 OS=Mus musculus OX=10090 GN=Dennd11 PE=2 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 5.718e-65
Identity = 133/385 (34.55%), Postives = 222/385 (57.66%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK---NNWEEC----VISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH V+SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+             +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+    ++  C     + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGGSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEGDYSPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLMDLLEAYGIDVMLVIDNPCC 454
[Close]
BLAST of DENN domain-containing protein 11 vs. UniProt/SwissProt
Match: sp|A4D1U4|DEN11_HUMAN (DENN domain-containing protein 11 OS=Homo sapiens OX=9606 GN=DENND11 PE=1 SV=1)

HSP 1 Score: 219.55 bits (558), Expect = 8.272e-65
Identity = 135/385 (35.06%), Postives = 223/385 (57.92%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK------NNWEE-CVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH ++SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+           + +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+      N  EE   + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FLL LLE YGID++  ID+ CC
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKIQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGSSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKINSADREKYRRLNEQRQMLLYSQEVEEDYNPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLLDLLEAYGIDVMLVIDNPCC 454
[Close]
BLAST of DENN domain-containing protein 11 vs. UniProt/SwissProt
Match: sp|Q0PGW2|DEN11_RAT (DENN domain-containing protein 11 OS=Rattus norvegicus OX=10116 GN=Dennd11 PE=2 SV=1)

HSP 1 Score: 219.55 bits (558), Expect = 8.360e-65
Identity = 133/385 (34.55%), Postives = 222/385 (57.66%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQT------IKTKNVIPISIDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQ--LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSK---NNWEEC----VISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + AVFVV+FD + GN++EWC+P D++  G+EFK++ SGSH V+SDF+YFR+  F+G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+             +P    L +    ++             +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  +  +    P+    F ++++D E  +    + ++VAC+T++I + K+  YD  +   N++  ++    +   + ++S+D+ K+ +L + RQ +  S+    ++  C     + FF  +NNR+   LL+++ S +  +T      +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:   77 VVAVFVVTFDPRSGNMVEWCLPQDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGGSLPPVYWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPESKPFFYVNVADIESLE---VEVSYVACTTEKIFEEKRELYDVYVDNQNVKTHHD---HLQPLLKLNSADREKYRRLNEQRQMLLYSQEVEGDYSPCEEDLFVLFFLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLMDLLEAYGIDVMLVIDNPCC 454
[Close]
BLAST of DENN domain-containing protein 11 vs. TrEMBL
Match: K1RBZ2 (Protein LCHN OS=Crassostrea gigas OX=29159 GN=CGI_10020441 PE=4 SV=1)

HSP 1 Score: 253.062 bits (645), Expect = 1.404e-75
Identity = 156/421 (37.05%), Postives = 248/421 (58.91%), Query Frame = 3 
Query:   51 DKDELLYTEVHNRFSNI-KPLDSNKTNEETPDNAIISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPIS--------IDLDNTAYNVFD----------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQY-LQPQLMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIR-------QNIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            D+DE      H+ F  I + LD +   +  P+   I  VFVV+FD + GN++EWC P D    G+EFKA+VSGSH  + DFVYFR+ + YG+ C+    + E + ERG RMK+VGILS SY+ L++HI+FL++ VRH L   G Y +L AFY+D+    K V+P S            +T  ++            + +F+  FG  IFTLWKLVLL+KRI+  S PPIG +C +V C   LG+H++ +L + +QP   F ++++D E  +    + A++AC+T++I + K + +D  +   + +++     ++ + + +S +DK K+ KLL+ R       + +     + EE V SFF  +NN L S LLD+A+S + ++T+  +  +G  P+ D+ FL+ L+E YGID+V  +D+ CC
Sbjct:   14 DEDEGPRLRHHHTFPTIHRSLDLSP--DSPPEADHIVCVFVVTFDTRSGNMIEWCAPDDFELDGVEFKAMVSGSHTQQKDFVYFRKERLYGLACYEKMSV-ESEIERGARMKSVGILSTSYTLLYRHIQFLEAQVRHQLELPGVYSQLQAFYNDK----KGVLPDSASSLVVSPASTPSTPSSLLPEMKITHPAGCFSQFIKFFGANIFTLWKLVLLQKRILFFSPPPIGVVCYKVYCACCLGNHEVGKLGHEVQPH--FYVNVADIETLE---SEVAYIACTTEKIFESKTSLHDVYV---DNQLITAHTPVLKDLLKLSDADKDKYNKLLNQRSANQFSYEGMGEDAIDEEELVTSFFTQQNNDLFSTLLDVAHSHDRQLTSDHMRSMGLDPQGDRTFLMELVEHYGIDVVLMVDNPCC 419
[Close]
BLAST of DENN domain-containing protein 11 vs. TrEMBL
Match: A0A2I4DCL8 (protein LCHN-like OS=Austrofundulus limnaeus OX=52670 GN=LOC106537154 PE=4 SV=1)

HSP 1 Score: 252.677 bits (644), Expect = 1.963e-74
Identity = 146/396 (36.87%), Postives = 219/396 (55.30%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTI---KTKNVIPISIDLDNTA-------------YNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEM----------MNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI--------DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GNI+EWC+P D+N  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L + G Y  L AFY D+      T N +  S  + + A             +      +F+  FG +I  LWK VLLRKR+++ S PP+G +C +V CC  L +  I  +    P+L   F I+++D    +      ++VAC+T++I + KK  YD  I   N++           +N AD               K+ KL + RQ +        DC+ N  E+  I FF   NNR+  +L ++A S +P +T   +  +G  P+ D+ FLL LL+ YGID+   ID+ CC
Sbjct:  125 IVAVFVVTFDTRSGNIIEWCLPHDINLDGVEFKSMASGSHRITSDFIYFRKGNYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQNPGQYSPLEAFYEDKKAVLPPTGNGLVTSCPMWSVASINRCMHPEMKITHPAGCMSQFIQFFGEQIMVLWKFVLLRKRLLIFSPPPVGVVCYRVYCCCSLANVSIPGIGVSVPELRPFFYINIADITALETEL---SYVACTTEKIFEDKKELYDVYIDNQNVKTHRSHLQQLLRLNAADKE-------------KYRKLSEQRQMLLYSQEVGEDCTSNE-EDLFILFFMELNNRIFQILSEVAASADPTLTADHVRAMGLDPQGDRSFLLDLLDVYGIDVALVIDNLCC 502
[Close]
BLAST of DENN domain-containing protein 11 vs. TrEMBL
Match: A0A060X0N3 (UDENN domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00053725001 PE=4 SV=1)

HSP 1 Score: 247.669 bits (631), Expect = 3.663e-73
Identity = 142/391 (36.32%), Postives = 220/391 (56.27%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVFDY---------------------ERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI--------DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH +  DF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P + +   TA     +                      +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D         + ++VAC+T++I + KK  YD  +   N++   ++   +   + ++  D+ K+ KL + RQ +        DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID +  ID+ CC
Sbjct:   67 IVAVFVVTFDTRSGNMVEWCLPQDVNLDGVEFKSMASGSHRIAKDFIYFRKGCYFGLACFANMPV-ESESERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGSYSPLEAFYEDK----KAVLPPAGNGLVTACPTSAWVPAINRCMHPEMKITHPAGCMSQFIHFFGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCSLANISIPGIGVSVPEFRPFFYINVADIAALA---TEMSYVACTTEKIFEEKKELYDVYVDNQNVKTHRDS---LQPLLRLNGVDREKYRKLSEQRQLLLYTQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAASADPTLTAEHVRAMGLDPQADRTFLVDLLELYGIDAMLVIDNPCC 445
[Close]
BLAST of DENN domain-containing protein 11 vs. TrEMBL
Match: A0A4W5J8L8 (Si:ch211-238n5.4 OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 5.203e-73
Identity = 142/391 (36.32%), Postives = 221/391 (56.52%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVFDY---------------------ERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI--------DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + +DF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P + +   TA     +                      +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D         + ++VAC+T++I + KK  YD  +   N++   ++   +   + ++  D+ K+ KL + RQ +        DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID +  ID+ CC
Sbjct:   56 IVAVFVVTFDTRSGNMVEWCLPQDVNLDGVEFKSMASGSHRIANDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGSYSPLEAFYEDK----KAVLPTAGNGLVTACPTSAWVPAINRCMHPEMKITHPAGCMSQFIHFFGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCSLANISIPGIGVSVPEFRPFFYINVADIAALA---TEMSYVACTTEKIFEEKKELYDVYVDNQNVKTHRDS---LQPLLRLNGVDREKYRKLSEQRQLLLYTQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAASADPTLTAEHVRAMGLDPQADRTFLVDLLELYGIDAMLVIDNPCC 434
[Close]
BLAST of DENN domain-containing protein 11 vs. TrEMBL
Match: A0A4W5JQN9 (Si:ch211-238n5.4 OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 1.771e-72
Identity = 142/391 (36.32%), Postives = 221/391 (56.52%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVFDY---------------------ERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI--------DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + +DF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P + +   TA     +                      +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D         + ++VAC+T++I + KK  YD  +   N++   ++   +   + ++  D+ K+ KL + RQ +        DC+ N  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P+ D+ FL+ LLE YGID +  ID+ CC
Sbjct:  107 IVAVFVVTFDTRSGNMVEWCLPQDVNLDGVEFKSMASGSHRIANDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGSYSPLEAFYEDK----KAVLPTAGNGLVTACPTSAWVPAINRCMHPEMKITHPAGCMSQFIHFFGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCSLANISIPGIGVSVPEFRPFFYINVADIAALA---TEMSYVACTTEKIFEEKKELYDVYVDNQNVKTHRDS---LQPLLRLNGVDREKYRKLSEQRQLLLYTQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLSEVAASADPTLTAEHVRAMGLDPQADRTFLVDLLELYGIDAMLVIDNPCC 485
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Cavefish
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:103035780])

HSP 1 Score: 236.884 bits (603), Expect = 6.401e-72
Identity = 145/391 (37.08%), Postives = 224/391 (57.29%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTA---------------------YNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + +DF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P   +   TA                     +      +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +      ++VAC+T++I + KK  YD  I   N++   E+   +   + ++++D+ K+ KL + RQ        + DC+ N  E+  I FF  +NNR+   LL++A S +P +T   +  +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:  114 IVAVFVVTFDTRSGNMVEWCLPQDVNLEGVEFKSMASGSHRIANDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDK----KAVLPSGGNGLVTACPTSALGTMVNRCMHPEMKITHPAGCMSQFIRFFGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGIGASVPEFRPFFYINVADITALETEL---SYVACTTEKIFEEKKELYDVYIDNQNVKTHRES---LQPLLRINNADREKYRKLSEQRQLLLYSQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLLEVAGSADPTLTAEHVRAMGLDPQGDRGFLVDLLEVYGIDVMLVIDNPCC 492
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Cavefish
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:103035780])

HSP 1 Score: 236.498 bits (602), Expect = 1.015e-71
Identity = 145/391 (37.08%), Postives = 224/391 (57.29%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTA---------------------YNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQ--------NIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P DVN  G+EFK++ SGSH + +DF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P   +   TA                     +      +F+  FG +I  LWK  LLRKRI++ S PP+G +C +V CC  L +  I  +    P+    F I+++D    +      ++VAC+T++I + KK  YD  I   N++   E+   +   + ++++D+ K+ KL + RQ        + DC+ N  E+  I FF  +NNR+   LL++A S +P +T   +  +G  P+ D+ FL+ LLE YGID++  ID+ CC
Sbjct:  114 IVAVFVVTFDTRSGNMVEWCLPQDVNLEGVEFKSMASGSHRIANDFIYFRKGCYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDK----KAVLPSGGNGLVTACPTSALGTMVNRCMHPEMKITHPAGCMSQFIRFFGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGIGASVPEFRPFFYINVADITALETEL---SYVACTTEKIFEEKKELYDVYIDNQNVKTHRES---LQPLLRINNADREKYRKLSEQRQLLLYSQEVDGDCTSNE-EDLFILFFMEQNNRIFQTLLEVAGSADPTLTAEHVRAMGLDPQGDRGFLVDLLEVYGIDVMLVIDNPCC 492
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Sea Lamprey
Match: dennd11 (DENN domain containing 11 [Source:NCBI gene;Acc:556432])

HSP 1 Score: 200.675 bits (509), Expect = 5.904e-60
Identity = 127/389 (32.65%), Postives = 207/389 (53.21%), Query Frame = 3 
Query:  141 DNAIISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNT--------------------AYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQP-QLMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI----DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            + A+++A FV +FD + GN LEWC P D    GIEFKA+ SG+H++ SDF YFR    +G+  F  R + +   ERGVR+K+VG LS SY+ L  H  FL   VR  L   G Y+ L  FY     + + V+P + +L  T                     ++     R ++ FG  +F LWKL LLRKR+++ S PP+G  C  V+CC  LGSH    L  + P + +F +S++D    +    +  ++AC+T+++ + K   YD  +   ++   +     +   ++ + +D+ ++ +L+  R+ +    D S+N      ++FF+  N+R+L  L+ LA SG  E+T S + H+G  P  D+ FL  L++ Y I++    D+ CC
Sbjct:   15 EAALVTAAFVATFDARTGNGLEWCAPHDAALVGIEFKAIASGAHNITSDFTYFRTDSAFGLAHFHSRRV-DSGPERGVRVKSVGALSPSYATLALHSAFLQEQVRRQLDEPGQYEALSEFYE----QYRAVLPFTTELPTTQLPSSQLPSTRTPLSWDRPLGHHAGCLSRLVSCFGPSVFCLWKLALLRKRMLLYSPPPVGGTCLHVLCCCCLGSHGQAGLGAVPPLKPLFYVSVADIGSLES---EVTYIACTTEKVFEDKTALYDVYVDRQSLRSHHS---HLQGLLAPTRADQSRYQQLVMQREVVSTGRDGSQNLDNGFFLTFFRELNSRVLGSLVRLAVSGVREVTESDVCHMGLDPVADRLFLADLIDLYAINVTISADNPCC 392
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Nematostella
Match: EDO30639 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T076])

HSP 1 Score: 146.747 bits (369), Expect = 1.445e-40
Identity = 84/205 (40.98%), Postives = 118/205 (57.56%), Query Frame = 3 
Query:  129 EETPDNAIISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFR-QYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSD--QTIKTKNVIPIS----------IDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVI 704
            E  PD  +I+AVF+V FD +KGNI+EW  P D + +G+EFKALVSGSH +  DFVYF+ +   YG+ C+  R   E   ERG RMK+VGIL   Y++LH+H+ FL+  V   L + G Y  L  ++      I   N +P            + +    +    + +F+  FG KIF LWKLVLL+KRI+  S PP+G  C + +
Sbjct:   53 ETLPD--LIAAVFIVHFDTRKGNIIEWKYPKDADLSGVEFKALVSGSHTITQDFVYFKTKDNLYGLSCYE-RISVENVEERGSRMKSVGILCARYTSLHEHMPFLEDEVTKQLDNPGHYGDLEDYFHSFKNCIVRNNFVPSPPPEHLPGLEDVPILKITHPAGCFPQFINFFGEKIFVLWKLVLLQKRILFFSPPPVGVACYRAL 254
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Medaka
Match: dennd11 (protein LCHN [Source:NCBI gene;Acc:101160730])

HSP 1 Score: 232.646 bits (592), Expect = 1.632e-70
Identity = 143/400 (35.75%), Postives = 218/400 (54.50%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVFD--------------------YERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEM----------MNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI--------DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I AVFVV+FD + GN++EWC+P D+N  G+EFK++ SGSH + SDF+YFR+  ++G+ CFA  P+ E + ERG RMK+VGILS SY+ L++++ FL++ VRH L   G Y  L AFY D+    K V+P + +   TA   +                       +F+  FG +I  LWK  LLRKR+++ S PP+G +C +V CC  L +  I  +    P+L   F ++++D    +    + ++VAC+T++I + KK  YD  +   N++           +N AD             K K+ KL + RQ +        DC+ N  E+  I FF   NNR+   L ++A S +P +T   +  +G  P+ D+ FL  LLE YGID+   +D+ CC
Sbjct:  100 IVAVFVVTFDTRSGNMVEWCLPHDINLDGVEFKSMASGSHRITSDFIYFRKAAYFGLACFANMPV-ESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDK----KAVLPPTGNGLVTACPTWSVTAINRCMHPEMKITHPAGCMSQFIQFFGEQIMVLWKFALLRKRLLIFSPPPVGVVCYRVYCCCCLANVSIPGIGVSVPELRPFFYVNIADISALE---TEMSYVACTTEKIFEDKKDLYDVYVDNQNVKTHRSHLQPLLKLNAAD-------------KEKYRKLGEQRQLLLYSQEVEEDCTSNE-EDLFILFFMELNNRIFQTLSEVAGSADPTLTVDHVRAMGLDPQGDRSFLADLLEVYGIDVTLVVDNLCC 477
[Close]
BLAST of DENN domain-containing protein 11 vs. Ensembl Medaka
Match: ENSORLT00000011196.2 (protein LCHN [Source:NCBI gene;Acc:101159630])

HSP 1 Score: 210.69 bits (535), Expect = 4.354e-62
Identity = 135/393 (34.35%), Postives = 215/393 (54.71%), Query Frame = 3 
Query:  153 ISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIP-----------------------ISIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQL--MFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNI--------DCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            I +VFVV+F+ + GN+LEWC+P D++  G+EFKA+ SGSH V +DF+YFR+  ++G+ CFA   + E   ERG RMK+VGILS SY+ L++++ FL+  VR  L   G Y  L AFY D+    + V+P                         + + + A  +  + RF   FG +I  LWKL LLR+RI++ S PP+G +C +V CC  L +  I  +    P+    F ++++D    +      ++VAC+T++I + KK  YD  +   N++   +    +   + +S++D+ K+ KL + RQ +        DC+ +  E+  I FF  +NNR+   L ++A S +P +T   +  +G  P  D+ FLL LLE YG D +   +  CC
Sbjct:  105 IVSVFVVTFNTRSGNMLEWCLPKDMDLEGVEFKAIASGSHRVTTDFIYFRKGCYFGLACFANMAV-ESMAERGARMKSVGILSTSYTLLYRYMSFLEHQVRLQLQSPGHYSPLEAFYEDK----RAVLPPDGGDAVTFPPGVWGSAINHSMHPEMKITHPAGCMSQFTRF---FGEQIMVLWKLALLRRRILIFSPPPVGVVCYRVYCCCCLANVSIPGVGVAVPEFRPFFYVNVADIGALENEL---SYVACTTEKIFEEKKDLYDVYVDNQNVKTHRDG---LKPLLRLSAADREKYRKLTEQRQMLLYSQEESGDCASSE-EDLFILFFLEQNNRIFQTLSEVAASPDPTVTQDSVRAMGLDPHGDRLFLLHLLEIYGYDTLMVSEQLCC 482
[Close]
BLAST of DENN domain-containing protein 11 vs. Planmine SMEST
Match: SMESG000068092.1 (SMESG000068092.1)

HSP 1 Score: 787.334 bits (2032), Expect = 0.000e+0
Identity = 394/397 (99.24%), Postives = 395/397 (99.50%), Query Frame = 3 
Query:   42 MDFDKDELLYTEVHNRFSNIKPLDSNKTNEETPDNAIISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQLMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADXXXXXXXXXXXXXXXKFAKLLDIRQNIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 1232
            MDFDKDELLYTEVHNRFSNIKPLDSNKTNEETPDN IISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDN AYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQP+LMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADSLISEAVSVSSSDKVKFAKLLDIRQNIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC
Sbjct:    1 MDFDKDELLYTEVHNRFSNIKPLDSNKTNEETPDNVIISAVFVVSFDHKKGNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALRPLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRLIAFYSDQTIKTKNVIPISIDLDNNAYNVFDYERFLTTFGIKIFTLWKLVLLRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPKLMFNISLSDTEQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADSLISEAVSVSSSDKVKFAKLLDIRQNIDCSKNNWEECVISFFKSENNRLLSVLLDLANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC 397
The following BLAST results are available for this feature:
BLAST of DENN domain-containing protein 11 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
DENND111.723e-6535.06DENN domain containing 11 [Source:HGNC Symbol;Acc:... [more]
DENND111.723e-6535.06DENN domain containing 11 [Source:HGNC Symbol;Acc:... [more]
DENND114.286e-6034.63DENN domain containing 11 [Source:HGNC Symbol;Acc:... [more]
DENND114.286e-6034.63DENN domain containing 11 [Source:HGNC Symbol;Acc:... [more]
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BLAST of DENN domain-containing protein 11 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DENN domain-containing protein 11 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DENN domain-containing protein 11 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
dennd119.942e-7237.44DENN domain containing 11 [Source:NCBI gene;Acc:55... [more]
dennd111.153e-7137.44DENN domain containing 11 [Source:NCBI gene;Acc:55... [more]
dennd111.346e-7137.44DENN domain containing 11 [Source:NCBI gene;Acc:55... [more]
dennd112.476e-5238.85DENN domain containing 11 [Source:NCBI gene;Acc:55... [more]
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BLAST of DENN domain-containing protein 11 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DENN domain-containing protein 11 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
E330009J07Rik8.175e-6634.55RIKEN cDNA E330009J07 gene [Source:MGI Symbol;Acc:... [more]
E330009J07Rik2.216e-5037.17RIKEN cDNA E330009J07 gene [Source:MGI Symbol;Acc:... [more]
E330009J07Rik2.001e-3251.89RIKEN cDNA E330009J07 gene [Source:MGI Symbol;Acc:... [more]
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BLAST of DENN domain-containing protein 11 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q1LX49|DEN11_DANRE7.505e-7137.44DENN domain-containing protein 11 OS=Danio rerio O... [more]
sp|Q4FZX0|DEN11_XENLA2.721e-6936.86DENN domain-containing protein 11 OS=Xenopus laevi... [more]
sp|Q3UHG7|DEN11_MOUSE5.718e-6534.55DENN domain-containing protein 11 OS=Mus musculus ... [more]
sp|A4D1U4|DEN11_HUMAN8.272e-6535.06DENN domain-containing protein 11 OS=Homo sapiens ... [more]
sp|Q0PGW2|DEN11_RAT8.360e-6534.55DENN domain-containing protein 11 OS=Rattus norveg... [more]
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BLAST of DENN domain-containing protein 11 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
K1RBZ21.404e-7537.05Protein LCHN OS=Crassostrea gigas OX=29159 GN=CGI_... [more]
A0A2I4DCL81.963e-7436.87protein LCHN-like OS=Austrofundulus limnaeus OX=52... [more]
A0A060X0N33.663e-7336.32UDENN domain-containing protein OS=Oncorhynchus my... [more]
A0A4W5J8L85.203e-7336.32Si:ch211-238n5.4 OS=Hucho hucho OX=62062 PE=4 SV=1[more]
A0A4W5JQN91.771e-7236.32Si:ch211-238n5.4 OS=Hucho hucho OX=62062 PE=4 SV=1[more]
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BLAST of DENN domain-containing protein 11 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dennd116.401e-7237.08DENN domain containing 11 [Source:NCBI gene;Acc:10... [more]
dennd111.015e-7137.08DENN domain containing 11 [Source:NCBI gene;Acc:10... [more]
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BLAST of DENN domain-containing protein 11 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
dennd115.904e-6032.65DENN domain containing 11 [Source:NCBI gene;Acc:55... [more]
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BLAST of DENN domain-containing protein 11 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DENN domain-containing protein 11 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO306391.445e-4040.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of DENN domain-containing protein 11 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dennd111.632e-7035.75protein LCHN [Source:NCBI gene;Acc:101160730][more]
ENSORLT00000011196.24.354e-6234.35protein LCHN [Source:NCBI gene;Acc:101159630][more]
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BLAST of DENN domain-containing protein 11 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000068092.10.000e+099.24SMESG000068092.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004395 ID=SMED30004395|Name=DENN domain-containing protein 11|organism=Schmidtea mediterranea sexual|type=transcript|length=1450bp
ATCAAGGTCATTTAACTGTTCCAAGTTAAAATTTTATTAATATGGATTTC
GACAAAGATGAATTATTATACACGGAAGTCCATAATCGTTTTTCAAATAT
CAAACCGCTGGATTCAAATAAAACCAACGAAGAAACTCCGGATAATGCGA
TTATTTCCGCAGTGTTTGTTGTTTCGTTTGATCACAAAAAAGGAAATATT
CTCGAGTGGTGCATGCCAGGGGACGTGAACTATACTGGTATTGAGTTCAA
AGCTCTAGTCAGTGGATCTCACCATGTTAAATCAGATTTTGTGTATTTCA
GACAATATCAGTTTTATGGCGTTGGTTGTTTTGCTTTACGCCCACTGAAA
GAAGAAGATGGTGAAAGGGGAGTACGCATGAAAACTGTGGGCATTCTATC
AAACTCATACTCGAATCTCCACCAACACATTGAATTCCTCGATTCAACAG
TAAGACATATCCTCGTTCATCATGGTGATTATGATAGATTAATTGCCTTT
TATTCTGACCAAACCATTAAAACAAAAAATGTTATCCCTATATCTATTGA
TCTTGATAATACTGCTTACAACGTATTTGATTACGAAAGGTTTCTTACCA
CGTTTGGAATAAAAATATTTACTCTTTGGAAATTAGTTTTGTTGCGTAAG
AGAATCATGGTCCTCTCCAATCCTCCAATCGGACCAATTTGTCAGCAAGT
TATTTGCTGTCATCGGCTCGGAAGTCACGACATAGATCAACTGCAATATT
TACAGCCCCAATTAATGTTCAATATCAGTTTGTCCGACACGGAGCAGTTC
AAACCGTCTTTCTGGCAGCAGGCGTTTGTCGCTTGTTCTACCGACCAAAT
CATACAAATCAAAAAAACTTGGTATGACTGCCTTATTCGAGAATCAAATA
TTGAAATGATGAATGAAGCAGATAGTTTAATTTCAGAAGCTGTCTCAGTG
TCATCGTCGGACAAAGTTAAATTTGCAAAATTATTAGATATCAGACAGAA
TATCGACTGTTCCAAAAATAATTGGGAAGAATGTGTTATCAGCTTTTTCA
AATCTGAAAACAATAGACTACTCTCAGTATTGTTGGATCTAGCAAATTCC
GGAGAGCCAGAAATTACTACATCTCAAATTGAACATCTAGGATTTCACCC
AAGAGAAGATAAAGATTTCCTTTTACTGTTATTAGAAACATATGGCATAG
ATTTAGTTTACCACATCGACTCCAAGTGTTGCTGATTATTGTTTGTTTGA
ATGAGATCATTATAAACACAAATAATAACAACCAGGGATTTTTATGTGTA
TTATGGTAAAAGTTGAGATATATGGTCGGTTTATAAATCGAAGATGTGAC
GAGAATATTATAATGGATATAATTAATATTTTATTTTATTTATTTTTCGT
TTATTTTGTTTTTGGGATTTTCAAAGTACTTAATAAATGTTATTGTTTTG
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protein sequence of SMED30004395-orf-1

>SMED30004395-orf-1 ID=SMED30004395-orf-1|Name=SMED30004395-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=398bp
MDFDKDELLYTEVHNRFSNIKPLDSNKTNEETPDNAIISAVFVVSFDHKK
GNILEWCMPGDVNYTGIEFKALVSGSHHVKSDFVYFRQYQFYGVGCFALR
PLKEEDGERGVRMKTVGILSNSYSNLHQHIEFLDSTVRHILVHHGDYDRL
IAFYSDQTIKTKNVIPISIDLDNTAYNVFDYERFLTTFGIKIFTLWKLVL
LRKRIMVLSNPPIGPICQQVICCHRLGSHDIDQLQYLQPQLMFNISLSDT
EQFKPSFWQQAFVACSTDQIIQIKKTWYDCLIRESNIEMMNEADSLISEA
VSVSSSDKVKFAKLLDIRQNIDCSKNNWEECVISFFKSENNRLLSVLLDL
ANSGEPEITTSQIEHLGFHPREDKDFLLLLLETYGIDLVYHIDSKCC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005085guanyl-nucleotide exchange factor activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR037516Tripartite_DENN
IPR029063SAM-dependent_MTases
IPR018626LCHN/Anr2
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0051179localization
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR018626Protein LCHN/Anr2PFAMPF09804DUF2347coord: 41..292
e-value: 5.0E-54
score: 183.8
NoneNo IPR availablePANTHERPTHR31017LATE SECRETORY PATHWAY PROTEIN AVL9-RELATEDcoord: 25..397
NoneNo IPR availablePANTHERPTHR31017:SF2PROTEIN LCHNcoord: 25..397
IPR037516Tripartite DENN domainPROSITEPS50211DENNcoord: 1..397
score: 14.057