Tyrosine-protein kinase receptor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004366 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: LTK (leukocyte receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6721]) HSP 1 Score: 222.631 bits (566), Expect = 3.730e-61 Identity = 112/280 (40.00%), Postives = 163/280 (58.21%), Query Frame = 1
Query: 4477 IGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G + + D+ Q + E DF EA+++ K+ H NIV +G+S + ++LE M G+++ +L+H RP + + S L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYR+ +P++WM PE +GIF+ K+D WSFGVL WEI + G PY G+TN EVL V+ G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 214 LGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRA-TPRLILLELMSGGDMKSFLRHSRPH--------------LGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS-RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQY 477
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:10261]) HSP 1 Score: 231.491 bits (589), Expect = 4.039e-60 Identity = 137/356 (38.48%), Postives = 191/356 (53.65%), Query Frame = 1
Query: 4273 YIHHRKTKRNNKLIKSNIIV----DAQTFELMNVNQGIKYEINSLYGFEKLPLTN-FDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHN-KNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYF 5316
++ HR+ K N K K + V D + EL + G+ N+ Y LP + +P E L L+G+GAFG V++GT + + VA+K S +E +F +EA L+ K+ HPNI+ LGV + Q +ILE ME G+L YL+ R L + DI + +LE +F+HRD+AARNCLVS+ + + RI K+GDFGLARDIY ++YYRK E +P+RWMAPE++ DGIF+ +SDVWSFG+L WEI+T G PY +N +VL V G +L P CP D++ +M QCW P+ RP F I Q F
Sbjct: 1874 FVWHRRLK-NQKSAKEGVTVLINEDKELAELRGLAAGVGLA-NACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL-LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV--------------DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2212
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:10261]) HSP 1 Score: 231.491 bits (589), Expect = 4.187e-60 Identity = 137/356 (38.48%), Postives = 191/356 (53.65%), Query Frame = 1
Query: 4273 YIHHRKTKRNNKLIKSNIIV----DAQTFELMNVNQGIKYEINSLYGFEKLPLTN-FDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHN-KNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYF 5316
++ HR+ K N K K + V D + EL + G+ N+ Y LP + +P E L L+G+GAFG V++GT + + VA+K S +E +F +EA L+ K+ HPNI+ LGV + Q +ILE ME G+L YL+ R L + DI + +LE +F+HRD+AARNCLVS+ + + RI K+GDFGLARDIY ++YYRK E +P+RWMAPE++ DGIF+ +SDVWSFG+L WEI+T G PY +N +VL V G +L P CP D++ +M QCW P+ RP F I Q F
Sbjct: 1880 FVWHRRLK-NQKSAKEGVTVLINEDKELAELRGLAAGVGLA-NACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL-LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV--------------DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: LTK (leukocyte receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6721]) HSP 1 Score: 223.402 bits (568), Expect = 1.142e-59 Identity = 112/280 (40.00%), Postives = 163/280 (58.21%), Query Frame = 1
Query: 4477 IGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G + + D+ Q + E DF EA+++ K+ H NIV +G+S + ++LE M G+++ +L+H RP + + S L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYR+ +P++WM PE +GIF+ K+D WSFGVL WEI + G PY G+TN EVL V+ G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 455 LGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRA-TPRLILLELMSGGDMKSFLRHSRPH--------------LGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS-RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQY 718
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: LTK (leukocyte receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6721]) HSP 1 Score: 223.402 bits (568), Expect = 2.850e-59 Identity = 112/280 (40.00%), Postives = 163/280 (58.21%), Query Frame = 1
Query: 4477 IGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G + + D+ Q + E DF EA+++ K+ H NIV +G+S + ++LE M G+++ +L+H RP + + S L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYR+ +P++WM PE +GIF+ K+D WSFGVL WEI + G PY G+TN EVL V+ G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 516 LGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRA-TPRLILLELMSGGDMKSFLRHSRPH--------------LGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS-RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQY 779
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: scd-2 (ALK tyrosine kinase receptor homolog scd-2 [Source:UniProtKB/Swiss-Prot;Acc:O76411]) HSP 1 Score: 194.897 bits (494), Expect = 1.337e-49 Identity = 115/352 (32.67%), Postives = 183/352 (51.99%), Query Frame = 1
Query: 4426 FDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDI-YFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYF-DGPRDIEETSTLSRLVMRSYNSSHESEFGINSDPVTEKTSIAFSEKYPEIGSL 5475
D +P I + + ++G G FG V+ G S K + K ++ + + S+ DF EA+ + + N+V L+G+ F+ + LEYME G+L +++ RP+ + +N L DLI I D+ K LE +VHRDIAARN L++ +R+ K+ DFG+A++I Y EYYR T MPI+W PE DG+F+ KSD+WSFGVLCWE+ + G PY + N EV+ + +G +L P P VY++M CWK RP+F+++ IFQ D P + + V ++ S + + + P+T T I+ + + + ++
Sbjct: 965 LDSLPSISRDSIERGRVLGRGNFGEVYYGEY---SGVKLAVKMIS-RTFSASQASQSDFCNEALCMGTFVDENVVRLIGIDFE-KVPYMIALEYMEGGDLLSFVKECRPNQVS-----------LNPFQ-LAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGP-QRVAKIADFGMAKEITYGTEYYRINGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVMLMLTEGARLEYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFPIHPAVRATFAHSQSTPVSVET-PMTAMTEISLNSTFTDASTV 1297
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: F11E6.8 (pep chromosome:WBcel235:IV:17444156:17447429:-1 gene:WBGene00008711.1 transcript:F11E6.8b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F11E6.8) HSP 1 Score: 181.03 bits (458), Expect = 3.056e-49 Identity = 100/288 (34.72%), Postives = 156/288 (54.17%), Query Frame = 1
Query: 4450 NECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISE----EDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSET---KMPIRWMAPETIKDG-IFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFL 5289
+E + ++G G FG V++G M D PVA+K G+ + E F RE V++ HP+++ LLG+S ++L YME G+L+ Y+ + N L +L+ A + + + +L ++FVHRD+AARNC++S RI K+ DFGLA D+ E Y SET ++P++W+APE+++D +FS +DVWSFGVL WE++T A PY +N +V + G +L +P CP +Y++M CW+ PE RP F+
Sbjct: 76 SEAVVLETIVGKGYFGNVYRGRM---RDPAGRLIPVAVKTLKGERARDIAHIEKFLREGVVMKHLDHPHVLSLLGISISPAGNPWVVLPYMEGGDLKTYIA--------------------DPNRALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMIS----ADRIVKVADFGLAVDLLDKESYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGEVSNTKVRHYLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFV 336
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: F11E6.8 (pep chromosome:WBcel235:IV:17444125:17450543:-1 gene:WBGene00008711.1 transcript:F11E6.8a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F11E6.8) HSP 1 Score: 182.185 bits (461), Expect = 4.375e-49 Identity = 100/288 (34.72%), Postives = 156/288 (54.17%), Query Frame = 1
Query: 4450 NECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISE----EDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSET---KMPIRWMAPETIKDG-IFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFL 5289
+E + ++G G FG V++G M D PVA+K G+ + E F RE V++ HP+++ LLG+S ++L YME G+L+ Y+ + N L +L+ A + + + +L ++FVHRD+AARNC++S RI K+ DFGLA D+ E Y SET ++P++W+APE+++D +FS +DVWSFGVL WE++T A PY +N +V + G +L +P CP +Y++M CW+ PE RP F+
Sbjct: 133 SEAVVLETIVGKGYFGNVYRGRM---RDPAGRLIPVAVKTLKGERARDIAHIEKFLREGVVMKHLDHPHVLSLLGISISPAGNPWVVLPYMEGGDLKTYIA--------------------DPNRALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMIS----ADRIVKVADFGLAVDLLDKESYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGEVSNTKVRHYLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFV 393
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1) HSP 1 Score: 180.644 bits (457), Expect = 3.241e-48 Identity = 104/277 (37.55%), Postives = 152/277 (54.87%), Query Frame = 1
Query: 4474 LIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYG-HPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+IG GAFG VFKG + + PVA+K +I EE +F RE ++ G H NIV + G D QC+I+EY+ G+L+ YLQ+ R ++K + +S +D+K+ +S + I + LE +HRD+AARN LV ++ K+ DFG++R Y K S+ +P+RW++PE IKD +S KSDVW+FGVL WEI T G PY + ++L + +G +L +P C D+Y +M CW E RP FL I
Sbjct: 194 VIGEGAFGQVFKGILRGPNGQVI---PVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMD-EQLQCMIMEYVPYGDLKHYLQNMR----KEK----------DSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVG----TGKVLKISDFGMSRP----GVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAI 444
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7217839:7221186:1 gene:WBGene00020106.1 transcript:R151.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1) HSP 1 Score: 180.259 bits (456), Expect = 8.511e-47 Identity = 104/277 (37.55%), Postives = 152/277 (54.87%), Query Frame = 1
Query: 4474 LIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYG-HPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+IG GAFG VFKG + + PVA+K +I EE +F RE ++ G H NIV + G D QC+I+EY+ G+L+ YLQ+ R ++K + +S +D+K+ +S + I + LE +HRD+AARN LV ++ K+ DFG++R Y K S+ +P+RW++PE IKD +S KSDVW+FGVL WEI T G PY + ++L + +G +L +P C D+Y +M CW E RP FL I
Sbjct: 357 VIGEGAFGQVFKGILRGPNGQVI---PVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMD-EQLQCMIMEYVPYGDLKHYLQNMR----KEK----------DSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVG----TGKVLKISDFGMSRP----GVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAI 607
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Alk (gene:FBgn0040505 transcript:FBtr0087118) HSP 1 Score: 234.958 bits (598), Expect = 1.229e-61 Identity = 126/347 (36.31%), Postives = 198/347 (57.06%), Query Frame = 1
Query: 4270 MYIHHRKTKRNNKLIKSNIIVDAQTFELMN-VNQGIKYEINSLYGFEKLPLTNFD--KIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKI--RNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+Y +++ K++ K K + D Q L N ++ N YG + + + D +P + + L + +G GAFG V+ + D + VA+K + K EEDF +EA ++ K+ HPN+V L+GV FD ++LE + G+L+++L+ +R N+ +R S+L KDL+ A D+ + +++E K F+HRDIAARNCL+S R+ K+ DFG++RDIY +YYRK + +PI+WM PE DGIF+ K+DVWSFG+L WE+ + G PY GQ N +V++ V+ G +LG P CP+ +Y++M CW PE RP F+ +
Sbjct: 1127 LYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYM-ALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFD-RQPYYIVLELLAGGDLQKFLRENR----------NTPER----PSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPG-RVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITL 1456
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Alk (gene:FBgn0040505 transcript:FBtr0331926) HSP 1 Score: 234.958 bits (598), Expect = 1.229e-61 Identity = 126/347 (36.31%), Postives = 198/347 (57.06%), Query Frame = 1
Query: 4270 MYIHHRKTKRNNKLIKSNIIVDAQTFELMN-VNQGIKYEINSLYGFEKLPLTNFD--KIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKI--RNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+Y +++ K++ K K + D Q L N ++ N YG + + + D +P + + L + +G GAFG V+ + D + VA+K + K EEDF +EA ++ K+ HPN+V L+GV FD ++LE + G+L+++L+ +R N+ +R S+L KDL+ A D+ + +++E K F+HRDIAARNCL+S R+ K+ DFG++RDIY +YYRK + +PI+WM PE DGIF+ K+DVWSFG+L WE+ + G PY GQ N +V++ V+ G +LG P CP+ +Y++M CW PE RP F+ +
Sbjct: 1127 LYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYM-ALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFD-RQPYYIVLELLAGGDLQKFLRENR----------NTPER----PSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPG-RVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITL 1456
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: sev (gene:FBgn0003366 transcript:FBtr0073393) HSP 1 Score: 220.32 bits (560), Expect = 6.196e-57 Identity = 113/287 (39.37%), Postives = 168/287 (58.54%), Query Frame = 1
Query: 4435 IPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKN---KRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRF 5286
+P I L +G+GAFG V++G + E D++ Q+ +R G S E +EA L+ + H NIV L+G+ FD + LI+E+ME G+L YL+ R ++ + L +L+++ D+ +LE+ +FVHRD+A RNCLV+ + +R K+GDFGLARDIY +YYRK E +P+RWM+PE++ DG+F+ +SDVW+FGVLCWEI+T G PY + N EVL V +G +L +P C +Y ++L CW+ P RP F
Sbjct: 2201 LPQINWSQLKLLRFLGSGAFGEVYEGQLKTE-DSEEPQRVAIKSLRKGASEFAE-LLQEAQLMSNFKHENIVCLVGICFDT-ESISLIMEHMEAGDLLSYLRAARATSTQEP----------QPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSF 2474
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Ror (gene:FBgn0010407 transcript:FBtr0079978) HSP 1 Score: 199.519 bits (506), Expect = 8.375e-53 Identity = 106/288 (36.81%), Postives = 159/288 (55.21%), Query Frame = 1
Query: 4432 KIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+I H + + + +G GAFG V+KG + + + ALK N +++DFKRE L+ H NIV +LGV + + C++ EYM G+L ++L + P E L + + IA I E +++L ++VHRD+AARNCLV+ + K+ DFGL+RDIY +YYR S++ +P+RWM E+I G F+ +SDVWSFGV+ WEI ++G PY G +N EV+ + + L PE CP VY +M++CW RP F +I
Sbjct: 401 RINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALK-ENASVKTQQDFKREIELISDLKHQNIVCILGVVLN-KEPYCMLFEYMANGDLHEFLISNSP----------------TEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVN----EGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDI 666
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0290232) HSP 1 Score: 204.912 bits (520), Expect = 2.249e-52 Identity = 106/278 (38.13%), Postives = 169/278 (60.79%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQ--CLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLI-SIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G G+FGMV++G + N ++ A+K N + E +F EA ++ ++ ++V LLGV C Q +++E M+KG+L+ YL+ HRP+ + + + + N T I +A +I + + +L K FVHRD+AARNC+V+ + K+GDFG+ RDIY +YYRK ++ +P+RWM PE+++DG++S SDV+SFGV+ WE+ T A PY G +N +VL+ VIDG + RPE CP ++++M +CW + RP FL+I
Sbjct: 1377 LGQGSFGMVYEGILKSFPPNGVDRE-CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGV---CSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVA----DDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ros1 (c-ros oncogene 1 , receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-020506-1]) HSP 1 Score: 223.402 bits (568), Expect = 3.090e-58 Identity = 129/345 (37.39%), Postives = 190/345 (55.07%), Query Frame = 1
Query: 4270 MYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLP-LTNFDKIPHILNECLNYSHLIGNGAFGMVFKG-TMTVESDNKTSQKPVALKI--RNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSI--HNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRF 5286
++ H K K + K + + + EL V + E N + P + +P +CL L+G+GAFG V++G T+ + + ++ VA+K ++ + +F +EA L+ ++ HPNI+ LLGV + LILE ME G+LR YL+ RP NN + L + + + D + +LE +FVHRDIAARNCLVS+ + +R+ K+GDFGLARD+Y ++YYRK E +P+RWM+PE++ DGIF+ SDVW+FGVL WEI+T G PY TN EVL + G +L P CP +Y +M+ CW P RP F
Sbjct: 875 IWQRHHKKKDHGKAKQPSSVQIHPDVELEYVRGLVGLE-NGCFAISNTPSRAEIESLPVFPRDCLKLQRLLGSGAFGEVYEGVTVGSQINGVEPERKVAIKTLQKDASDYEKTEFLKEAHLMSQFNHPNILRLLGVCL-LNEPHYLILELMEGGDLRSYLRGARP-------TNNHKELLSLSSLLDISLDAAT-------GCAYLERMHFVHRDIAARNCLVSVRTYTDPERVVKIGDFGLARDVYKNDYYRKKGEGLLPVRWMSPESLTDGIFNKYSDVWAFGVLLWEILTLGKLPYPTYTNHEVLSYISTGGRLSSPAGCPQRLYNLMMSCWSKQPADRPNF 1203
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: alk (ALK receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-031027-1]) HSP 1 Score: 214.927 bits (546), Expect = 4.316e-58 Identity = 117/309 (37.86%), Postives = 179/309 (57.93%), Query Frame = 1
Query: 4378 YEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEED---FKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
Y N +G + + + ++P ++ + +G+GAFG V++G + V + S VA+K + SE+D F EA+++ K+ H NIV +GVS ++LE M G+L+ +L+ RP +L++ S+ ++ DL++IA DI ++LEE F+HRDIAARNCL++ R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY ++N EVL+ V +G ++ P+ CP VY +M Q W++ PE RP F I
Sbjct: 35 YNPNYCFGGKTASVNDLKEVPR---RNISLTRGLGHGAFGEVYEG-LAVGIPGEPSPMQVAVKTLP-EVCSEQDELDFLMEALIISKFSHQNIVRCIGVSLQA-LPHFILLELMAGGDLKSFLRETRP-----RLEHPSSLTMV---------DLLNIARDIARGCQYLEENQFIHRDIAARNCLLTCKGPG-RVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQPEDRPNFSTI 322
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: alk (ALK receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-031027-1]) HSP 1 Score: 214.927 bits (546), Expect = 8.607e-56 Identity = 117/309 (37.86%), Postives = 179/309 (57.93%), Query Frame = 1
Query: 4378 YEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEED---FKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
Y N +G + + + ++P ++ + +G+GAFG V++G + V + S VA+K + SE+D F EA+++ K+ H NIV +GVS ++LE M G+L+ +L+ RP +L++ S+ ++ DL++IA DI ++LEE F+HRDIAARNCL++ R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY ++N EVL+ V +G ++ P+ CP VY +M Q W++ PE RP F I
Sbjct: 565 YNPNYCFGGKTASVNDLKEVPR---RNISLTRGLGHGAFGEVYEG-LAVGIPGEPSPMQVAVKTLP-EVCSEQDELDFLMEALIISKFSHQNIVRCIGVSLQA-LPHFILLELMAGGDLKSFLRETRP-----RLEHPSSLTMV---------DLLNIARDIARGCQYLEENQFIHRDIAARNCLLTCKGPG-RVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQPEDRPNFSTI 852
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ltk (leukocyte receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030616-115]) HSP 1 Score: 207.994 bits (528), Expect = 2.727e-53 Identity = 119/338 (35.21%), Postives = 186/338 (55.03%), Query Frame = 1
Query: 4294 KRNNKLIKSNIIVDAQTFELMNVNQG-IKYEINSLYGF--EKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
++ N L I + + ++L + I + N YG+ + L+ ++P + + +G+GAFG V++G + + +N Q + E DF EA+++ K+ H NIV +GVS + ++LE M G+++ +L+ +RP N +S L +L+ +A DI ++LEE +F+HRDIAARNCL++ + R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY +TN EVL+ V G ++ P++CP VY +M QCW++ PE RP F I
Sbjct: 854 RKKNHLHAVRIRLQSPEYKLSKIRSSTIMTDYNPNYGYFGKAASLSELKEVP---RKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDEMDFLMEALIMSKFSHQNIVRCIGVSLQILPRF-ILLELMTGGDMKSFLRLNRPRT--------------NHSSSLSMLELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGPD-RVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTI 1172
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ltk (leukocyte receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030616-115]) HSP 1 Score: 207.994 bits (528), Expect = 2.783e-53 Identity = 119/338 (35.21%), Postives = 186/338 (55.03%), Query Frame = 1
Query: 4294 KRNNKLIKSNIIVDAQTFELMNVNQG-IKYEINSLYGF--EKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
++ N L I + + ++L + I + N YG+ + L+ ++P + + +G+GAFG V++G + + +N Q + E DF EA+++ K+ H NIV +GVS + ++LE M G+++ +L+ +RP N +S L +L+ +A DI ++LEE +F+HRDIAARNCL++ + R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY +TN EVL+ V G ++ P++CP VY +M QCW++ PE RP F I
Sbjct: 880 RKKNHLHAVRIRLQSPEYKLSKIRSSTIMTDYNPNYGYFGKAASLSELKEVP---RKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDEMDFLMEALIMSKFSHQNIVRCIGVSLQILPRF-ILLELMTGGDMKSFLRLNRPRT--------------NHSSSLSMLELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGPD-RVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTI 1198
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ncapd3 (non-SMC condensin II complex subunit D3 [Source:Xenbase;Acc:XB-GENE-990932]) HSP 1 Score: 244.202 bits (622), Expect = 3.963e-64 Identity = 156/455 (34.29%), Postives = 232/455 (50.99%), Query Frame = 1
Query: 3943 HNRIMWKP-GKTNGDNILDYKIKMNFQNHLQKFNSIKNTYFDIAKSNQTGTISVEARNIVGFSLPSYLSLKLTDTRKQISHYYLHSTMTFXXXXXXXXXXXXXXXXXXXXMYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLTNF-DKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKI--RNGKSISEEDFKREAVLLFKYGHPNIVILLGVS-FDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSI--HNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRF 5286
N I W P + NG NI+ Y ++ + N Q+F N F N GT A G L Y ++T + I + L ++ ++Y ++ + + I+ D + +L ++ + N Y LP +K+P+ E L +G+GAFG V++G +T K VA+K R+ + +F +EA L+ ++ HPNI+ LLGV F+ P Q +ILE M+ G+L YL+ R +N +L T DL+ I+ +I +LE+ +FVHRD+AARNCLVS+ +N RI K+GDFGLARDIY +YYRK E +P+RWMAPE++ DGIF+ +SDVWSFG++ WE+ T G PY G +N EVL V G+++ P CP DV+ ++ +CW P RP F
Sbjct: 1476 QNIIQWMPVEEDNGSNIIYYILEYSSNNCNQEFAITCNESFTALWRN-FGTFEFRAAAANGIGLGEY-----SNTSESIIFFKLSVCIS-------------------TALYWMSKQKSQKKETTAVAILEDKELMKLRRLSDAVGLA-NGCYAVSILPTQKEKEKLPNFPREKLTLCVFLGSGAFGEVYEGAAIDILGPETGIKKVAVKTLKRDATDHEKTEFLKEAHLMSQFDHPNILKLLGVCLFNEP--QYIILELMDGGDLLTYLRGAR-----------------TQNPLLSTLDLLDISENISRGCAYLEKMHFVHRDLAARNCLVSVKEYNNPSRIVKIGDFGLARDIYKCDYYRKNGEGLLPVRWMAPESLIDGIFTCRSDVWSFGIVLWEVFTMGQQPYPGFSNLEVLHHVQSGQRMCSPTNCPDDVWSLIQKCWAQDPWKRPAF 1885
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ENSXETT00000011701.1 (leukocyte receptor tyrosine kinase [Source:NCBI gene;Acc:100498306]) HSP 1 Score: 227.254 bits (578), Expect = 2.023e-63 Identity = 124/347 (35.73%), Postives = 194/347 (55.91%), Query Frame = 1
Query: 4276 IHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGI---KYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE----DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
++HRK K +L + + + + ++L + I Y N + + L+ ++P + + +G+GAFG V++G + S + P+ + I+ I E DF EA+++ K+ H NIV +GVS + ++LE M G+++ +L+ +RP IN+ S L DL+++A DI K+LEE +F+HRDIAARNCL++ ++ R+ K+GDFG+ARDIY YYRK +P++WM PE +G+F+ K+D WSFGVL WEI + G PY +TN EVL+ V G ++ P+ CP VY +M QCW++ PE RP F I
Sbjct: 10 VYHRKKK---QLEGARVRLQSTEYKLSKIRSSIIMTDYNPNYCFAGKGASLSELKEVPR---KNITLLRALGHGAFGEVYEGMVVGISGDP---NPLQVAIKTLPEICSEQDEMDFLMEALIISKFSHQNIVRCIGVSLQTLPR-FILLELMSGGDMKSFLRQNRP--------------WINQPSTLSMLDLLNMARDIACGCKYLEENHFIHRDIAARNCLLT-YSGTGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGVFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHTPEHRPNFSTI 331
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ENSXETT00000028153.1 (leukocyte receptor tyrosine kinase [Source:NCBI gene;Acc:100498306]) HSP 1 Score: 227.639 bits (579), Expect = 2.735e-63 Identity = 125/347 (36.02%), Postives = 194/347 (55.91%), Query Frame = 1
Query: 4276 IHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGI---KYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE----DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
I+HRK K +L + + + + ++L + I Y N + + L+ ++P + + +G+GAFG V++G + S + P+ + I+ I E DF EA+++ K+ H NIV +GVS + ++LE M G+++ +L+ +RP IN+ S L DL+++A DI K+LEE +F+HRDIAARNCL++ ++ R+ K+GDFG+ARDIY YYRK +P++WM PE +G+F+ K+D WSFGVL WEI + G PY +TN EVL+ V G ++ P+ CP VY +M QCW++ PE RP F I
Sbjct: 27 IYHRKKK---QLEGARVRLQSTEYKLSKIRSSIIMTDYNPNYCFAGKGASLSELKEVPR---KNITLLRALGHGAFGEVYEGMVVGISGDP---NPLQVAIKTLPEICSEQDEMDFLMEALIISKFSHQNIVRCIGVSLQTLPR-FILLELMSGGDMKSFLRQNRP--------------WINQPSTLSMLDLLNMARDIACGCKYLEENHFIHRDIAARNCLLT-YSGTGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGVFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHTPEHRPNFSTI 348
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ncapd3 (non-SMC condensin II complex subunit D3 [Source:Xenbase;Acc:XB-GENE-990932]) HSP 1 Score: 239.965 bits (611), Expect = 8.646e-63 Identity = 134/345 (38.84%), Postives = 196/345 (56.81%), Query Frame = 1
Query: 4270 MYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLT-NFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKI--RNGKSISEEDFKREAVLLFKYGHPNIVILLGVS-FDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSI--HNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRF 5286
+Y ++ + + I+ D + +L ++ + N Y LP +K+P+ E L +G+GAFG V++G +T K VA+K R+ + +F +EA L+ ++ HPNI+ LLGV F+ P Q +ILE M+ G+L YL+ R D Q N +L T DL+ I+ +I +LE+ +FVHRD+AARNCLVS+ +N RI K+GDFGLARDIY +YYRK E +P+RWMAPE++ DGIF+ +SDVWSFG++ WE+ T G PY G +N EVL V G+++ P CP DV+ ++ +CW P RP F
Sbjct: 1604 LYWMSKQKSQKKETTAVAILEDKELMKLRRLSDAVGLA-NGCYAVSILPTQKEKEKLPNFPREKLTLCVFLGSGAFGEVYEGAAIDILGPETGIKKVAVKTLKRDATDHEKTEFLKEAHLMSQFDHPNILKLLGVCLFNEP--QYIILELMDGGDLLTYLRGARVDSFTQ-------------NPLLSTLDLLDISENISRGCAYLEKMHFVHRDLAARNCLVSVKEYNNPSRIVKIGDFGLARDIYKCDYYRKNGEGLLPVRWMAPESLIDGIFTCRSDVWSFGIVLWEVFTMGQQPYPGFSNLEVLHHVQSGQRMCSPTNCPDDVWSLIQKCWAQDPWKRPAF 1932
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ENSXETT00000028190.1 (leukocyte receptor tyrosine kinase [Source:NCBI gene;Acc:100498306]) HSP 1 Score: 225.713 bits (574), Expect = 8.679e-63 Identity = 124/346 (35.84%), Postives = 193/346 (55.78%), Query Frame = 1
Query: 4279 HHRKTKRNNKLIKSNIIVDAQTFELMNVNQGI---KYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE----DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+HRK K +L + + + + ++L + I Y N + + L+ ++P + + +G+GAFG V++G + S + P+ + I+ I E DF EA+++ K+ H NIV +GVS + ++LE M G+++ +L+ +RP IN+ S L DL+++A DI K+LEE +F+HRDIAARNCL++ ++ R+ K+GDFG+ARDIY YYRK +P++WM PE +G+F+ K+D WSFGVL WEI + G PY +TN EVL+ V G ++ P+ CP VY +M QCW++ PE RP F I
Sbjct: 16 YHRKKK---QLEGARVRLQSTEYKLSKIRSSIIMTDYNPNYCFAGKGASLSELKEVPR---KNITLLRALGHGAFGEVYEGMVVGISGDP---NPLQVAIKTLPEICSEQDEMDFLMEALIISKFSHQNIVRCIGVSLQTLPR-FILLELMSGGDMKSFLRQNRP--------------WINQPSTLSMLDLLNMARDIACGCKYLEENHFIHRDIAARNCLLT-YSGTGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGVFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHTPEHRPNFSTI 336
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ltk (leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840]) HSP 1 Score: 225.328 bits (573), Expect = 3.061e-63 Identity = 116/281 (41.28%), Postives = 167/281 (59.43%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRN--GKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G +T + +S PVA+K E DF EA+++ K+ H NIV +G+SF + ++LE M G+++ +L+H RP + + L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYRK T +P++WM PE + +G+F+ K+D WSFGVL WEI + G PY G TN EVL + G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 100 LGHGAFGEVYEGLVTGLPGD-SSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRS-APRLILLELMSGGDMKSFLRHSRPHP--------------GQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGAS-RVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQY 363
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ltk (leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840]) HSP 1 Score: 224.942 bits (572), Expect = 5.694e-62 Identity = 116/281 (41.28%), Postives = 167/281 (59.43%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRN--GKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G +T + +S PVA+K E DF EA+++ K+ H NIV +G+SF + ++LE M G+++ +L+H RP + + L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYRK T +P++WM PE + +G+F+ K+D WSFGVL WEI + G PY G TN EVL + G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 200 LGHGAFGEVYEGLVTGLPGD-SSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRS-APRLILLELMSGGDMKSFLRHSRPHP--------------GQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGAS-RVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQY 463
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ltk (leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840]) HSP 1 Score: 225.328 bits (573), Expect = 2.537e-60 Identity = 116/281 (41.28%), Postives = 167/281 (59.43%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRN--GKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G +T + +S PVA+K E DF EA+++ K+ H NIV +G+SF + ++LE M G+++ +L+H RP + + L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYRK T +P++WM PE + +G+F+ K+D WSFGVL WEI + G PY G TN EVL + G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 451 LGHGAFGEVYEGLVTGLPGD-SSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRS-APRLILLELMSGGDMKSFLRHSRPHP--------------GQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGAS-RVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQY 714
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ltk (leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840]) HSP 1 Score: 225.328 bits (573), Expect = 5.252e-60 Identity = 116/281 (41.28%), Postives = 167/281 (59.43%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRN--GKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G +T + +S PVA+K E DF EA+++ K+ H NIV +G+SF + ++LE M G+++ +L+H RP + + L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYRK T +P++WM PE + +G+F+ K+D WSFGVL WEI + G PY G TN EVL + G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 512 LGHGAFGEVYEGLVTGLPGD-SSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPR-LILLELMSGGDMKSFLRHSRPHP--------------GQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGAS-RVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQY 775
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ros1 (Ros1 proto-oncogene [Source:MGI Symbol;Acc:MGI:97999]) HSP 1 Score: 226.098 bits (575), Expect = 1.206e-58 Identity = 163/526 (30.99%), Postives = 251/526 (47.72%), Query Frame = 1
Query: 3787 INDLHPGIFYQFIFTFNFTMSKLQGIVTCQCFSKDDVPDSPVNVSILRQNFTHNRIMWKPGKTNGDNILDYKIKM------NFQNHLQK----FNSIKNTYFDIAKSNQTGTISVEA--RNIVGFSLPSYLSLKLTDTRKQISHYYLHSTMTFXXXXXXXXXXXXXXXXXXXXMYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLTN-FDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHN-KNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYF 5316
I DL P Y +T + + +K VP P +L + N I W+ + NG ++ Y +++ + QN + FN ++ N GT A N +G S +S +T + + ++ + + + +V + H+ +K ++ N D + EL + G+ N+ Y +P + +P E L+ L+G+GAFG V++GT + + VA+K S +E +F +EA L+ K+ HPNI+ LGV + Q +ILE ME G+L YL+ R L DL+ + DI + +LE+ +F+HRD+AARNCLVS+ + + R+ K+GDFGLAR+IY ++YYRK E +P+RWMAPE + DGIF+ +SDVWSFG+L WEI+T G PY +N +VL V G +L P CP D++ +M QCW P+ RP F I Q F
Sbjct: 1709 ITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEG--SKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGV--WITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDN---DKELAELRGLAAGVGLA-NACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL-LGEPQYIILELMEGGDLLSYLRKARGTTFH--------------GPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLF 2211
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|P00529|ROS_AVISU (Tyrosine-protein kinase transforming protein ros OS=UR2 sarcoma virus OX=354090 GN=V-ROS PE=3 SV=1) HSP 1 Score: 229.18 bits (583), Expect = 1.461e-64 Identity = 136/371 (36.66%), Postives = 202/371 (54.45%), Query Frame = 1
Query: 4273 YIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEI---NSLYGFEKLP-LTNFDKIPHILNECLNYSHLIGNGAFGMVFKGT-MTVESDNKTSQKPVALKIRNGKSISEE-DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVS--IHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEID----------LIFQYFDGPRD 5331
++ H++ K I++ + EL + +G+ + N+ Y LP + +P + LN L+G+GAFG V++GT + + +D + ++ G + E+ +F +EA L+ K+ HP+I+ LLGV + Q LILE ME G+L YL+ R +QK ++ DL+ I DI + +LE+ F+HRD+AARNCLVS + R+ K+GDFGLARDIY ++YYRK E +P+RWMAPE++ DG+F+ SDVW+FGVL WE +T G PY G +N EVL V G +L P CP D+ ++M +CW P RP F I L F YF G ++
Sbjct: 33 FVWHQRWKSRKPASTGQIVLVKEDKELAQL-RGMAETVGLANACYAVSTLPSQAEIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHILKLLGVCL-LNEPQYLILELMEGGDLLSYLRGAR----KQKFQSPLLT----------LTDLLDICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQPYPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEIRHSPLCFSYFLGDKE 387
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|Q63132|ROS1_RAT (Proto-oncogene tyrosine-protein kinase ROS OS=Rattus norvegicus OX=10116 GN=Ros1 PE=2 SV=1) HSP 1 Score: 233.032 bits (593), Expect = 7.446e-60 Identity = 137/356 (38.48%), Postives = 196/356 (55.06%), Query Frame = 1
Query: 4273 YIHHRKTKRNNKLIKSNIIV----DAQTFELMNVNQGIKYEINSLYGFEKLPLTN-FDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHN-KNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYF 5316
++ HR K N+K K + V D + EL + G+ N+ Y LP + +P E L+ L+G+GAFG V++GT + + VA+K S +E +F +EA L+ K+ HPNI+ LGV + Q +ILE ME G+L YL+ R + L L DL+ + DI + +LE+ +F+HRD+AARNCLVS+ + + R+ K+GDFGLAR+IY +YYRK E +P+RWMAPE + DGIF+ +SDVWSFG+L WEI+T G PY +N +VL V G +L P CP D++ +M +CW P+ RP F I Q F
Sbjct: 1872 FVWHRSLK-NHKATKEGLSVLNDNDQELAELRGLAAGVGLA-NACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEVYEGTAVDILGRGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL-LSEPQYIILELMEGGDLLSYLRKARGTTLSGPL--------------LTLADLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKHDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCWAQEPDQRPTFYNIQDQLQLF 2210
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|P08922|ROS1_HUMAN (Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens OX=9606 GN=ROS1 PE=1 SV=3) HSP 1 Score: 231.491 bits (589), Expect = 2.010e-59 Identity = 137/356 (38.48%), Postives = 191/356 (53.65%), Query Frame = 1
Query: 4273 YIHHRKTKRNNKLIKSNIIV----DAQTFELMNVNQGIKYEINSLYGFEKLPLTN-FDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHN-KNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYF 5316
++ HR+ K N K K + V D + EL + G+ N+ Y LP + +P E L L+G+GAFG V++GT + + VA+K S +E +F +EA L+ K+ HPNI+ LGV + Q +ILE ME G+L YL+ R L + DI + +LE +F+HRD+AARNCLVS+ + + RI K+GDFGLARDIY ++YYRK E +P+RWMAPE++ DGIF+ +SDVWSFG+L WEI+T G PY +N +VL V G +L P CP D++ +M QCW P+ RP F I Q F
Sbjct: 1880 FVWHRRLK-NQKSAKEGVTVLINEDKELAELRGLAAGVGLA-NACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL-LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV--------------DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|P08923|LTK_MOUSE (Leukocyte tyrosine kinase receptor OS=Mus musculus OX=10090 GN=Ltk PE=1 SV=3) HSP 1 Score: 225.328 bits (573), Expect = 3.673e-59 Identity = 116/281 (41.28%), Postives = 167/281 (59.43%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRN--GKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQY 5313
+G+GAFG V++G +T + +S PVA+K E DF EA+++ K+ H NIV +G+SF + ++LE M G+++ +L+H RP + + L +DL+ +A DI + +LEE +F+HRDIAARNCL+S + R+ K+GDFG+ARDIY YYRK T +P++WM PE + +G+F+ K+D WSFGVL WEI + G PY G TN EVL + G ++ P CP VY +M QCW++ PE RP F I QY
Sbjct: 512 LGHGAFGEVYEGLVTGLPGD-SSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPR-LILLELMSGGDMKSFLRHSRPHP--------------GQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGAS-RVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQY 775
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|P20806|7LESS_DROVI (Protein sevenless OS=Drosophila virilis OX=7244 GN=sev PE=3 SV=1) HSP 1 Score: 229.565 bits (584), Expect = 7.514e-59 Identity = 123/286 (43.01%), Postives = 169/286 (59.09%), Query Frame = 1
Query: 4435 IPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNK--NKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRF 5286
+P I L +G+GAFG V++G + E D Q+ +R G S E +EA L+ + H NIV L+G+ D D LI+E+ME G+L YL+ RP +S + L S L +L+S+ D+ ++E+ +FVHRD+A RNCLVS +RI K+GDFGLARDIY +YYRK E +P+RWMA E++ DG+FS +SDVW+FGVLCWEI T G PY + N EVL V +G +L +PE CP +Y ++LQCW+ P RP F
Sbjct: 2216 LPQINWNRLTLLRFLGSGAFGEVYEGQLQAE-DEAQPQRVAIKSLRKGASEFAE-LLQEAQLMSNFKHENIVCLIGICCDT-DSISLIMEHMEAGDLLSYLRAARP---------SSQEAL----SKLQLPELLSMCLDVANGCSYMEDMHFVHRDLACRNCLVSDGAAIGGRRIVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMALESLVDGLFSTQSDVWAFGVLCWEIFTLGQQPYAARNNFEVLAHVKEGGRLQQPERCPEKLYALLLQCWRSEPWERPSF 2485
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A4S2MCM5 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001009 PE=3 SV=1) HSP 1 Score: 308.145 bits (788), Expect = 3.573e-85 Identity = 160/377 (42.44%), Postives = 219/377 (58.09%), Query Frame = 1
Query: 4309 LIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVI------------RQKLKNNSTKRLINENS---------------------------------ILDTKDLISIAS---DILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
L S I +D T E M NQ E+NSLYG K L +F+++ I + + +G GAFG V++G + V + + + VALK+RN KS+SE +FKREA L+ +Y H NIV GVSFD P +QCL+LE M++GNLR YL RP + +N+T S ++ DL ++ S DI + ++LEE++FVHRDIAARNCLVS ++ + RI KL DFGLARDIY ++ YRK +E K+P+RWM+PE I+DG+F+ KSDVW+F V CWE+MT GADP+ G+ N +V+ VI G LGRPE CP ++Y MLQCW + E RP F ++
Sbjct: 18 LTTSGIPLDLSTLEPM-WNQ----EVNSLYGIGKSDLLSFEQVTQISAAHIRFERYVGCGAFGKVWEGWLHVNASDGDRFEKVALKVRNSKSLSEAEFKREATLMHRYQHANIVRFFGVSFDSPGQQCLVLEMMDQGNLRDYLHRARPRIAPHVAANMFAAAAICAAGSNATDLPTAAGSEGSSMNTSTTSTAAAGGGNAGGGAFSTNSNVITLIAQLDLAALVSIMRDIAQGCRYLEEQHFVHRDIAARNCLVSHNHPSGRIVKLCDFGLARDIYKNDCYRKRNEPKLPVRWMSPEAIRDGLFTTKSDVWAFAVTCWEVMTLGADPFYGRANVDVMNLVIGGHVLGRPENCPEELYNQMLQCWSRFTEMRPSFADL 389
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A158QCK7 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 PE=3 SV=1) HSP 1 Score: 294.278 bits (752), Expect = 1.513e-79 Identity = 150/354 (42.37%), Postives = 216/354 (61.02%), Query Frame = 1
Query: 4351 LMNVNQGIKYEINSLYGF-------EKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKP----VALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNS-------TKRLINE---------------------NSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
L ++ E+NSLYG L N + IP L Y IG GAFG V++G + S ++ + VALK+RN KS+SE +FKREA+L+ +Y H NIV G+S D P+ QCL+LE M++GNLR+YL RP + + ++ S + RL + +++L DL+ I DI + ++LEE++FVHRDIAARNCLVS ++++ RI KL DFGLARDIY ++YYRK +E K+P+RWM+PE I +G+F+ KSD+W++ V CWE+M+ GADP+ GQ N EV+ +++G L +P+ CP +Y+ MLQCW +PE RP F E+
Sbjct: 247 LSSMEPAWSQEVNSLYGAGVAISGDADEGLFNLNVIPASQLRFLRY---IGCGAFGKVWEGRYLISSSGCSNPEDRFERVALKVRNVKSLSESEFKREAILMQRYQHENIVRFYGISMDSPNHQCLVLEMMDQGNLREYLHRARPRLTPSQAEHFSRQEHTARSDRLSRQTETTEATTGESFCSGAGAVELHALLTIPDLLKIMWDIAKGCQYLEEQHFVHRDIAARNCLVSHNHESGRIVKLCDFGLARDIYKNDYYRKRNEPKLPVRWMSPEAILEGVFTSKSDIWAYAVTCWEVMSLGADPFYGQVNLEVINLILNGNVLSKPDNCPTALYDHMLQCWSRFPEIRPTFAEV 597
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A3P6WQ09 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS1632 PE=3 SV=1) HSP 1 Score: 294.278 bits (752), Expect = 1.555e-79 Identity = 150/354 (42.37%), Postives = 216/354 (61.02%), Query Frame = 1
Query: 4351 LMNVNQGIKYEINSLYGF-------EKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKP----VALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNS-------TKRLINE---------------------NSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
L ++ E+NSLYG L N + IP L Y IG GAFG V++G + S ++ + VALK+RN KS+SE +FKREA+L+ +Y H NIV G+S D P+ QCL+LE M++GNLR+YL RP + + ++ S + RL + +++L DL+ I DI + ++LEE++FVHRDIAARNCLVS ++++ RI KL DFGLARDIY ++YYRK +E K+P+RWM+PE I +G+F+ KSD+W++ V CWE+M+ GADP+ GQ N EV+ +++G L +P+ CP +Y+ MLQCW +PE RP F E+
Sbjct: 247 LSSMEPAWSQEVNSLYGAGVAISGDADEGLFNLNVIPASQLRFLRY---IGCGAFGKVWEGRYLISSSGCSNPEDRFERVALKVRNVKSLSESEFKREAILMQRYQHENIVRFYGISMDSPNHQCLVLEMMDQGNLREYLHRARPRLTPSQAEHFSRQEHTARSDRLSRQTETTEATTGESFCSGAGAVELHALLTIPDLLKIMWDIAKGCQYLEEQHFVHRDIAARNCLVSHNHESGRIVKLCDFGLARDIYKNDYYRKRNEPKLPVRWMSPEAILEGVFTSKSDIWAYAVTCWEVMSLGADPFYGQVNLEVINLILNGNVLSKPDNCPTALYDHMLQCWSRFPEIRPTFAEV 597
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A068WLW2 (Tyrosine protein kinase OS=Echinococcus granulosus OX=6210 GN=EgrG_000641500 PE=3 SV=1) HSP 1 Score: 293.893 bits (751), Expect = 1.066e-78 Identity = 150/344 (43.60%), Postives = 210/344 (61.05%), Query Frame = 1
Query: 4381 EINSLYGF-------EKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKP----VALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVI--------RQKLKNNSTKR--------------------LINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
E+NSLYG L N + IP L Y +G GAFG V++G + V + + + VALK+RN KS+SE +F+REA+L+ +Y H NIV G+S D P+ QCLILE ME+GNLR+YL RP + RQ+ S + + +++L DLI I DI ++LEE++FVHRDIAARNCLVS ++++ RI KL DFGLARDIY ++YYRK +E K+P+RWM+PE I +G+F+ KSD+W++ V CWE+M+ GADP+ GQ N EV+ V++G L +P+ CP +Y+ MLQCW +PE RP F ++
Sbjct: 357 EVNSLYGAGVAISGETNEALLNLNLIPASQLRFLRY---VGCGAFGKVWEGRLLVATSGCPNSEGKFERVALKVRNVKSLSEAEFRREALLMQRYQHENIVRFYGISMDSPNHQCLILEMMEQGNLREYLHRSRPRLTPSQAEHLSRQEHTARSDRSSRQTETTEATTGESMCSGLGAVELHAMLTIPDLIRIMRDIARGCRYLEEQHFVHRDIAARNCLVSHNHESGRIVKLCDFGLARDIYKNDYYRKRNEPKLPVRWMSPEAILEGLFTSKSDIWAYAVTCWEVMSLGADPFYGQVNLEVINLVLNGNVLSKPDNCPATLYDHMLQCWSRFPEIRPTFSDV 697
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A068Y2N7 (Tyrosine protein kinase OS=Echinococcus multilocularis OX=6211 PE=3 SV=1) HSP 1 Score: 289.271 bits (739), Expect = 3.409e-77 Identity = 145/341 (42.52%), Postives = 206/341 (60.41%), Query Frame = 1
Query: 4381 EINSLYG----FEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKP----VALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINEN----------------------------SILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
E+NSLYG + I L + +G GAFG V++G + V + + + VALK+RN KS+SE +F+REA+L+ +Y H NIV G+S D P+ QCLILE ME+GNLR+YL RP + + ++ S + + ++L DLI I DI ++LEE++FVHRDIAARNCLVS ++++ RI KL DFGLARDIY ++YYRK +E K+P+RWM+PE I +G+F+ KSD+W++ V CWEIM+ GADP+ GQ N EV+ V++G L +P+ CP +Y+ MLQCW +PE RP F ++
Sbjct: 357 EVNSLYGAGVTISGENNEALLNLNLIPASQLRFLRYVGCGAFGKVWEGRLLVAASGCPNSEDRFERVALKVRNVKSLSEVEFRREALLMQRYQHENIVRFYGISMDSPNHQCLILEMMEQGNLREYLHRSRPRLTPSQAEHLSRQEHTARSDRSSRQTETTEATTGESVCSGLGAFELHAMLTIPDLIRIMRDIARGCRYLEEQHFVHRDIAARNCLVSHNHQSGRIVKLCDFGLARDIYKNDYYRKRNEPKLPVRWMSPEAILEGLFTSKSDIWAYAVTCWEIMSLGADPFYGQVNLEVINLVLNGNVLSKPDNCPAALYDHMLQCWSRFPEIRPTFSDV 697
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: alk (ALK receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-031027-1]) HSP 1 Score: 213.772 bits (543), Expect = 6.679e-59 Identity = 113/276 (40.94%), Postives = 167/276 (60.51%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEED---FKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G+GAFG V++G + V + S VA+K + SE+D F EA+++ K+ H NIV +GVS + ++LE M G+L+ +L+ RP +L++ S+ ++ DL++IA DI ++LEE F+HRDIAARNCL++ R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY ++N EVL+ V +G ++ P+ CP VY +M Q W++ PE RP F I
Sbjct: 54 LGHGAFGEVYEG-LAVGIPGEPSPMQVAVKTLP-EVCSEQDELDFLMEALIISKFSHQNIVRCIGVSLQA-LPRFILLELMAGGDLKSFLRETRP-----RLEHPSSLTMV---------DLLNIAKDIARGCQYLEENQFIHRDIAARNCLLTCKGPG-RVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPQNCPGPVYRIMTQSWQHQPEDRPNFSTI 311
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: ENSAMXT00000021554.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:40807788:40819525:1 gene:ENSAMXG00000020937.2 transcript:ENSAMXT00000021554.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 205.297 bits (521), Expect = 3.078e-57 Identity = 122/305 (40.00%), Postives = 174/305 (57.05%), Query Frame = 1
Query: 4339 QTFELMNVNQGIKYEINSLYGFEKLPL-TNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTV-ESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSI--HNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVY 5235
Q EL N+ +G+ N+ Y LP+ + +P E L L+G+GAFG V++G +S + T + VA+K + +E +F +EA L+ ++ H NI+ LLGV + +ILE ME G+LR YL RP N +LD L+ I+ D+ + +LE+ +F+HRD+AARNCLVS+ + +R+ K+GDFGLARD+Y +YYRK E +P+RWM PE++ DGIF+ SDVW+FGVL WEIMT G PY +N EVL V G +L P CP +Y
Sbjct: 46 QDKELENI-RGLVGLGNACYAVSALPVHKEVESLPLFRREGLKLLKLLGSGAFGEVYEGVAARGQSGDATPDQRVAVKTLRKHAAEQEKIEFLKEAHLMSQFNHSNILRLLGVCV-LNEPHYIILELMEGGDLRSYLIGARPSN--------------NRGQLLDLTGLLDISLDVAKGCAYLEKLHFIHRDLAARNCLVSVRGYADPERVVKIGDFGLARDVYKSDYYRKRGEGLLPVRWMPPESLTDGIFNKHSDVWAFGVLLWEIMTLGKQPYPAFSNQEVLHHVNVGGRLPAPAECPQSLY 334
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 198.364 bits (503), Expect = 2.537e-52 Identity = 106/291 (36.43%), Postives = 160/291 (54.98%), Query Frame = 1
Query: 4459 LNYSHLIGNGAFGMVFKGTMTVESDNKTSQKP---VALKIRNGKSIS--EEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENS---ILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIF 5307
+ Y IG GAFG VF+ + +P VA+K+ ++ + + DF+REA L+ ++ HPNIV LLGV CL+ EYM G+L ++L+ P R + + T + S L + +S++ + + +L E+ FVHRD+A RNCLV + K+ DFGL+R+IY +YY+ + +PIRWM PE+I ++ +SDVW++GV+ WEI + G PY G + EV+ V DG L PE CP+++Y +M CW +P RP F I I
Sbjct: 390 IEYVRDIGEGAFGRVFQA----RAPGLLPHEPFTMVAVKMLKEEASADMQNDFQREAALMAEFDHPNIVRLLGVC-AVGKPMCLMFEYMAHGDLNEFLRRRSPAQQRSLSQGSLTDQSFASESDPTPLSCLEKLSMSKQVAAGMAYLSERKFVHRDLATRNCLVG----EDLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSHGMQPYYGMAHEEVIYYVRDGHVLACPENCPLELYNLMRLCWSRHPNDRPSFASIHRIL 671
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: ntrk3b (neurotrophic receptor tyrosine kinase 3 [Source:NCBI gene;Acc:103046759]) HSP 1 Score: 199.904 bits (507), Expect = 2.559e-52 Identity = 109/282 (38.65%), Postives = 156/282 (55.32%), Query Frame = 1
Query: 4462 NYSHL----------IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECR 5277
NYSH+ +G GAFG VF S K +++ + +DF+REA LL H +IV GV D D ++ EYM+ G+L ++L+ H PD L + + N L ++ +A+ I + +L ++FVHRD+A RNCLV N + K+GDFG++RDIY +YYR T +PIRWM PE+I FS +SDVWSFGV+ WEI T+G P+ +N EV++ V G+ L RP CP +VY++ML CW+ P+ R
Sbjct: 483 NYSHMNRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLAARKDFQREAELLTNLQHDHIVKFYGVCVD-SDPLIMVFEYMKHGDLNKFLRAHGPD--GTILVDGHP---MQSNGELGLSQMLHVATQIAAGMVYLSSQHFVHRDLATRNCLVG----NGLLVKIGDFGMSRDIYSMDYYRVGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVILWEIFTYGKQPWFQLSNNEVIEYVTQGRVLDRPRLCPKEVYDLMLGCWQSEPQQR 754
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: igf1ra (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:103037538]) HSP 1 Score: 203.371 bits (516), Expect = 4.700e-52 Identity = 106/275 (38.55%), Postives = 166/275 (60.36%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G G+FGMV++G ++ K VA+K N + E +F EA ++ ++ ++V LLGV +I+E M +G+L+ YL+ +R K + + ++ L + K +I +A +I + + +L FVHRD+AARNC+V+ K+GDFG+ RDIY +YYRK + +P+RWM+PE++KDG+F+ SDVWSFGV+ WEI T PY G +N +VL+ V++G L +P+ CP ++E+M CW+Y P+ RP FLEI
Sbjct: 998 LGQGSFGMVYEGIAKGVVKDEPETK-VAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQ-GQPTLVIMELMTRGDLKSYLRS-----LRSKQQGSCSQPLPS------LKKMIQMAGEISDGMAYLNANKFVHRDLAARNCMVA----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1255
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009485.1 (pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 201.83 bits (512), Expect = 7.774e-58 Identity = 109/281 (38.79%), Postives = 165/281 (58.72%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTM--TVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSIL----DTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G G FGMV++G V+ +++T VA+K N + E +F EA ++ + ++V LLGV +I+E M +G+L+ YL+ RPD + T+ ++ E +++ +A +I + + +L K FVHRD+AARNC+V+ K+GDFG+ RDIY +YYRK + +P+RWM+PE++KDG+F+ SDVWSFGV+ WEI T PY G +N +VLK V+DG L P CP + E++ +CW+Y P RP FLEI
Sbjct: 19 LGQGTFGMVYEGLARGIVKGEDETR---VAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQA-QPILVIMELMTRGDLKSYLRSLRPDA------EDFTETIVLEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVA----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 285
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009481.1 (pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009481.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 204.527 bits (519), Expect = 9.454e-57 Identity = 108/277 (38.99%), Postives = 164/277 (59.21%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTM--TVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G G FGMV++G V+ +++T VA+K N + E +F EA ++ + ++V LLGV +I+E M +G+L+ YL+ RPD ++ + S+ +++ +A +I + + +L K FVHRD+AARNC+V+ K+GDFG+ RDIY +YYRK + +P+RWM+PE++KDG+F+ SDVWSFGV+ WEI T PY G +N +VLK V+DG L P CP + E++ +CW+Y P RP FLEI
Sbjct: 67 LGQGTFGMVYEGLARGIVKGEDETR---VAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQA-QPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSS-----------LPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVA----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 324
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ltk (leukocyte receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030616-115]) HSP 1 Score: 207.223 bits (526), Expect = 2.539e-55 Identity = 116/327 (35.47%), Postives = 177/327 (54.13%), Query Frame = 1
Query: 4378 YEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE----DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYF-DEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYFDGPRDIEET 5343
Y N + L++ ++P +N +G+GAFG V++G +T P+ + ++ I E DF EA+++ K+ H NIV +GVS + ++LE M G+++ YL+ RP R + DL+++A DI ++LE+ +F+HRDIAARNCL++ + RI K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY ++N EV++ V G ++ P+ CP+ VY +M QCW++ PE RP F I Y D+ +T
Sbjct: 429 YNPNYCFAGSPAALSDLKEVPR---RNINLLRALGHGAFGEVYEGRVT-----GIEPSPLKVAVKTLPEICSEQDELDFLMEALIISKFNHHNIVRCVGVSLQTLPR-FILLELMAGGDMKTYLREERP-------------RAVCAGPRKSMLDLLTMAKDIACG-QYLEDNHFIHRDIAARNCLLTSKGSD-RIAKIGDFGMARDIYSRASYYRKGGRAMLPVKWMPPEAFLEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVMEFVTSGGRMDPPKNCPVPVYRIMTQCWQHRPEDRPNFSTILERITYCTQDPDVVQT 731
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 193.741 bits (491), Expect = 1.909e-54 Identity = 103/272 (37.87%), Postives = 156/272 (57.35%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISE---EDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLIL--EYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECR 5277
+G GAFG V+ + S Q+P+ + + K +S+ +DF REA LL H +IV GV C + + LI+ EYM+ G+L ++L+ PD + + RL+++ +L+ + S I + +L ++FVHRD+A RNCLV + K+GDFG++RD+Y +YYR T +PIRWM PE+I F+ SDVWS GV+ WEI T+G P+ +N EV+ + G+ L RP +CP++VYE+ML CW P+ R
Sbjct: 82 LGEGAFGKVY---LAECSSLDVGQEPMLVAAKTLKDLSDGARKDFYREAELLTNLQHEHIVRFYGV---CVEGEPLIMVFEYMKNGDLNKFLRLRGPDAVFMGDAPQAEPRLLSQAQMLN------MGSQIAAGMAYLASQHFVHRDLATRNCLVG----AGLVVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCICQGRVLERPRSCPMEVYELMLGCWHREPQHR 337
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001705.1 (pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 gene:ENSPMAG00000001543.1 transcript:ENSPMAT00000001705.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 183.726 bits (465), Expect = 2.655e-52 Identity = 90/243 (37.04%), Postives = 138/243 (56.79%), Query Frame = 1
Query: 4591 EEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQ--CLILEYMEKGNLRQYLQHHRPD--VIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIF 5307
+ +F REA L+ ++ HPNIV LLGV C + CL+ E+M G+L +YL+ + + + +E L D + +A+ + + +L E+ FVHRD+A RNCLV N+ + K+ DFGL++ IY +YY+ +PIRWM PE+I ++ +SDVW+FGV+ WEI + G PY G ++ EV+ V DG L P+ CP+D+Y +M CW + P RP F + +
Sbjct: 5 QANFHREAALMAEFTHPNIVKLLGV---CAVGKPFCLLFEFMPHGDLNEYLRRCSSEAGLAASSPPARAPTSSGSEPVSLCCADKLFVATQVAAGMAYLAERKFVHRDLATRNCLVG----NRLVVKISDFGLSQSIYAADYYKANENDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSHGLQPYFGMSHEEVIYFVRDGNVLACPDGCPLDLYNLMRLCWAHAPADRPSFASVQHVL 240
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: ATG1 (Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p; essential for cell cycle progression from G2/M to G1 under nitrogen starvation [Source:SGD;Acc:S000003148]) HSP 1 Score: 87.0409 bits (214), Expect = 2.042e-17 Identity = 83/304 (27.30%), Postives = 137/304 (45.07%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVA-LKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQC---LILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINE--------NSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSI-----HNK------------NKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQ-LGRPETCPI--DVYEMMLQCWKYYPECRPRFLE 5292
IG G+F V++G +T + + K V+ K++N K + E+ + E +L K HP+IV L+ DC LI+EY G+L L+ + + ++N+ R + E ++ L ++S + ALKFL KN VHRDI +N L+S H+ N I K+ DFG AR + + P+ +MAPE + ++ K+D+WS G + +E M G P+ + E+ K + + P C I ++ E++ + P R F E
Sbjct: 30 IGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLL--ENLEIEIAILKKIKHPHIVGLI----DCERTSTDFYLIMEYCALGDLTFLLKRRK-----ELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFAR--FLPNTSLAETLCGSPL-YMAPEILNYQKYNAKADLWSVGTVVFE-MCCGTPPFRASNHLELFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRIGFEE 318
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 82.4185 bits (202), Expect = 4.777e-16 Identity = 89/306 (29.08%), Postives = 131/306 (42.81%), Query Frame = 1
Query: 4468 SHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGH-PNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGI-FSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLG-RPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYFDGPRDIEETSTLSRLVMR 5370
+ +IG G FG+V+KG N + + A+K+ N S S+E D +RE L NI G S+ +I+E+ G+LR L RP I D K + I ++L ALK + + N +HRDI A N L++ N+ KL DFG+A + R+T P WMAPE I +G+ + K D+WS G+ +EI T G PY ++ +I K + + E + C P + R DL+ F TS L L+ R
Sbjct: 26 TEVIGRGKFGVVYKGY------NVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYG-SYLKDTSLWIIMEHCAGGSLRSLL---RPGKI-------------------DEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLIT----NEGNVKLCDFGVAAQVNQTSLRRQT-MAGTPY-WMAPEVIMEGVYYDTKVDIWSLGITTYEIAT-GNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDP--KERLSADDLLKSKFIRAHKATPTSILKELISR 293
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 80.4925 bits (197), Expect = 1.720e-15 Identity = 72/284 (25.35%), Postives = 122/284 (42.96%), Query Frame = 1
Query: 4450 NECLNYSHLIGNGAFGMVFKGTMT--------VESDNKTSQKP-----VALK-IRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDG--KQLGRPETCPIDVYEMMLQC 5253
++C G GA G V+ T +E N +P VA+K + K +E E +++ H NIV L D +++E+ME G+L D+I N+ N +S L + I + + LKFL +K+ +HRDI + N L+ + K+ DFG + D+ ++ + P WMAPE +K + K DVWS G++ E++ G PY+ + + L + +L PE+ +++ + C
Sbjct: 543 SQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLT--------DIIENSPTND------NSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRAR----VKITDFGFCARL-TDKRSKRATMVGTPY-WMAPEVVKQREYDEKIDVWSLGIMTIEMLE-GEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVC 805
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130]) HSP 1 Score: 76.2554 bits (186), Expect = 8.118e-15 Identity = 64/237 (27.00%), Postives = 108/237 (45.57%), Query Frame = 1
Query: 4591 EEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDL 5301
++ F+RE + HPN+ G F + L++EY+ G + + L+ H P N IL + + IA+ AL ++ +KN +HRDI N L+ +N + KL DFG + I E RKT I +++PE ++ + D W+ GVL +E++T GA P+ + K I + P D +++L+ KY P+ R R ++ +
Sbjct: 146 QKQFRREVEIQTSLNHPNLTKSYGY-FHDEKRVYLLMEYLVNGEMYKLLRLHGP-----------------FNDILASDYIYQIAN----ALDYMHKKNIIHRDIKPENILIGFNN----VIKLTDFGWS-IINPPENRRKTVCGT--IDYLSPEMVESREYDHTIDAWALGVLAFELLT-GAPPFEEEMKDTTYKR-IAALDIKMPSNISQDAQDLILKLLKYDPKDRMRLGDVKM 351
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 78.1814 bits (191), Expect = 8.330e-15 Identity = 77/282 (27.30%), Postives = 119/282 (42.20%), Query Frame = 1
Query: 4465 YSHL--IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYG-HPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDG--KQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
Y++L IG GA G V+ E S VA+K N + +++ +L+ K HPNIV + S+ +I+EYME G+L + H IL + ++ + L L+FL K +HRDI + N L+S+ KL DFG I + ++T+ P WMAPE + + K D+WS G++ E M G PY+ +T L + +L PE + + + C PE R E+
Sbjct: 620 YANLVKIGQGASGGVYTA---YEIGTNVS---VAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFID-SYVLKGDLWVIMEYMEGGSLTDVVTH----------------------CILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGD----IKLTDFGFCAQIN-ELNLKRTTMVGTPY-WMAPEVVSRKEYGPKVDIWSLGIMIIE-MIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATEL 865
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 218.779 bits (556), Expect = 1.530e-63 Identity = 107/274 (39.05%), Postives = 169/274 (61.68%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEE-DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+GNG+FGMV++G T NK K + SI + +F +EA ++ + ++V LLGV D +++E M+ G+L+ +L+ HRP+V + + T + ++ +A +I + + +L + FVHRD+AARNC+V N N + K+GDFG+ RDIY +YYRK + +P+RWMAPE++KDG+F+ SDVWSFGV+ WE+ T + PY G++N EVLK V+DG + +P+ CP ++++M CW++ P+ RP FL I
Sbjct: 24 LGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSDG-QPTLVVMELMDNGDLKNFLRSHRPEVTMESDEPPPT-----------LQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMV---NANLTV-KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPKPDDCPDRLFDLMTLCWQFSPKARPTFLSI 281
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO35408 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ9]) HSP 1 Score: 191.045 bits (484), Expect = 3.126e-54 Identity = 109/295 (36.95%), Postives = 166/295 (56.27%), Query Frame = 1
Query: 4441 HILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISE----EDFKREAVLLFKYG-HPNIVILLGV-SFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIF 5307
I +C+ IG G FG+VF GT+ + D + I+ K + + +D K E ++ + G HPN+V L+G + + P +I EY+ GNL D +RQ + +S + +N NS L ++DL+ IA D+ ++ + K FVHRD+AARN L++ + K+ DFGLARDIY + Y KT ++PI+WMAPE I+D +++ ++DVWSFGVL WEI+T G PY G A +L+ ++ G ++ P C +VY +M CW+ P RP F E+ I
Sbjct: 5 EIPRDCVTLGDRIGEGQFGIVFAGTVKIGEDT------IKAAIKCIKDVDDRYDMKDLKLEMEMMKEIGYHPNVVSLIGTCTIETP--LYIITEYVSGGNLL--------DQLRQSRRTDS--KYVNVNSTLTSRDLLRIALDVSRGMRHIAMKKFVHRDLAARNVLMT----DTLTAKVADFGLARDIYCEGKYVKTGGGRLPIKWMAPEAIRDQVYTTQTDVWSFGVLLWEIVTLGRSPYPGVPIAMLLEKLLYGYKMPCPSHCSEEVYSVMESCWQLEPSARPGFGELSKIL 277
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8]) HSP 1 Score: 186.422 bits (472), Expect = 6.757e-52 Identity = 106/285 (37.19%), Postives = 161/285 (56.49%), Query Frame = 1
Query: 4459 LNYSHLIGNGAFGMVFKGTMT-VESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYG-HPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDV-IRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIY-FDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+ + ++G+GAFG V K T+ + + + VA+K N + E+ +F E ++ + G H NIV +LG + CLI EY G+LR YL+ R V R L + R + +N DL+S A I +++L +K FVHRD+AARN L+ N + K+ DFGL RD+Y EY++ + K+P++WMAPE I + + KSDVW+FGV+ WEI+T G PY GQ+ E K + +G ++ +P+ C ++Y MM CW PE RP F ++
Sbjct: 18 IAFGEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILGCVTHA-GQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQN------DLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDN----LVKISDFGLTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKL 291
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO47097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN91]) HSP 1 Score: 181.03 bits (458), Expect = 1.630e-50 Identity = 103/279 (36.92%), Postives = 154/279 (55.20%), Query Frame = 1
Query: 4474 LIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISE-EDFKREAVLLFKYG-HPNIVILLGVSFDCPDKQC---LILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
++G GAFG VF V NK + ++ + SE D E +L G H NIV LLG ++C +I+EY GNL +L+ R DV + K + DL+ + + A++FL + VHRD+AARN LV + K+ DFGLARDIY +E+Y KT+ +P++WMA E + D +++ SDVWSFGVL WEI T G PY G EV + +++G+++ +PE CP ++Y++ML+CW++ P RP F ++
Sbjct: 21 IVGTGAFGQVFLAE-AVGISNKQVTRVACKGLKENATDSEYRDLLSELKILMHIGEHKNIVNLLGAC--TKGRECDLLVIIEYCPHGNLLNFLRKRR-DVFEATWSPPTEK----PDETFTLTDLVITSFQVSRAMQFLASRRCVHRDLAARNVLVG----ENYVMKIADFGLARDIYKEEHYVKTTAGLLPVKWMAIEALVDQVYTHSSDVWSFGVLLWEIFTLGGSPYPGLPANEVYQYLMEGQRMAQPEDCPQEMYDLMLRCWQHDPAQRPTFTQL 287
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO39761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S933]) HSP 1 Score: 176.792 bits (447), Expect = 6.279e-50 Identity = 91/217 (41.94%), Postives = 127/217 (58.53%), Query Frame = 1
Query: 4636 HPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRF 5286
HPN+V LL VS + + +I E+M +G+L YL+ +P +S + + D KDL+ IA + ++++ FVHRD+A RNCLV + K+ DFG++RD+Y +YY+ + ET +PIRW+APE G F+ KSDV+S+GVL WEI TFG PY G TN EV + + G LGRP+ CP VY +M CW PE R F
Sbjct: 20 HPNVVKLLAVSTE-EEPYGMIFEFMGEGDLNHYLRSAKP-------AESSAYKGPD-----DAKDLVGIAEQVAAGMEYVASLRFVHRDLATRNCLVG----TDMVVKIADFGMSRDVYGSDYYKMSRETMLPIRWLAPEAFLYGKFTVKSDVYSYGVLLWEIFTFGLQPYYGYTNKEVTEFIKKGIHLGRPDDCPQFVYLIMKDCWSREPEERVDF 219
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ltk (ALK tyrosine kinase receptor [Source:NCBI gene;Acc:101156784]) HSP 1 Score: 214.542 bits (545), Expect = 1.920e-55 Identity = 108/274 (39.42%), Postives = 160/274 (58.39%), Query Frame = 1
Query: 4477 IGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G+GAFG V++G + + D Q V E DF EA+++ K+ H NIV +GVS + + ++LE M G+++ +L+ +RP + S L ++L+ +A DI ++LEE F+HRDIAARNCL++ +R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D+WSFGVL WEI++ G PY +TN EVL+ V G ++ P+ CP VY +M QCW++ P RP F I
Sbjct: 908 LGHGAFGEVYEGQVLGMNPDGSPMQVAVKTLPEICSEQDEMDFLMEALIMSKFSHENIVRCIGVSLNILPRF-ILLELMIGGDMKTFLRQNRPRT--------------GQASSLTMRELLQMARDIANGCRYLEENQFIHRDIAARNCLLTCTGP-ERVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFVEGIFTCKTDIWSFGVLLWEILSLGYMPYPCKTNQEVLEFVTSGGRMDPPKGCPGPVYRLMTQCWQHCPNQRPNFSTI 1165
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ltk (ALK tyrosine kinase receptor [Source:NCBI gene;Acc:101156784]) HSP 1 Score: 214.542 bits (545), Expect = 2.184e-55 Identity = 108/274 (39.42%), Postives = 160/274 (58.39%), Query Frame = 1
Query: 4477 IGNGAFGMVFKG-TMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G+GAFG V++G + + D Q V E DF EA+++ K+ H NIV +GVS + + ++LE M G+++ +L+ +RP + S L ++L+ +A DI ++LEE F+HRDIAARNCL++ +R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D+WSFGVL WEI++ G PY +TN EVL+ V G ++ P+ CP VY +M QCW++ P RP F I
Sbjct: 876 LGHGAFGEVYEGQVLGMNPDGSPMQVAVKTLPEICSEQDEMDFLMEALIMSKFSHENIVRCIGVSLNILPRF-ILLELMIGGDMKTFLRQNRPRT--------------GQASSLTMRELLQMARDIANGCRYLEENQFIHRDIAARNCLLTCTGP-ERVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFVEGIFTCKTDIWSFGVLLWEILSLGYMPYPCKTNQEVLEFVTSGGRMDPPKGCPGPVYRLMTQCWQHCPNQRPNFSTI 1133
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: alk (ALK receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-031027-1]) HSP 1 Score: 204.912 bits (520), Expect = 3.189e-55 Identity = 109/275 (39.64%), Postives = 159/275 (57.82%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDF--KREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G+GAFG V++G + V + S VA+KI +S+ F K + K+ H NIV +GV + ++LE M G+L+ +L+ RP + + S L DL+++A DI + ++LEE F+HRDIAARNCL++ R+ K+GDFG+ARDIY YYRK +P++WM PE +GIF+ K+D WSFGVL WEI + G PY ++N EVL+ V +G ++ P+ CP VY +M Q W++ PE RP F I
Sbjct: 104 LGHGAFGEVYEG-LAVGIPGEQSPLQVAVKI-----LSKVYFFMKLRVFICSKFSHQNIVHCIGVCLQA-MPRFILLELMAGGDLKTFLRETRPR--------------LEQPSSLTMVDLLNVARDIAKGCQYLEENQFIHRDIAARNCLLTCKGPG-RVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQPEDRPNFSTI 356
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ENSORLT00000039357.1 (insulin receptor [Source:NCBI gene;Acc:101168764]) HSP 1 Score: 209.534 bits (532), Expect = 5.302e-54 Identity = 112/277 (40.43%), Postives = 164/277 (59.21%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTM--TVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G G+FGMV++G V+ D +T VA+K N + E +F EA ++ + ++V LLGV +++E M G+L+ YL+ RPD +NN + KD++ +A++I + + +L K FVHRD+AARNC+V K+GDFG+ RDIY +YYRK + +P+RWMAPE++KDG+F+ SD WSFGV+ WEI T PY G +N +VLK V+DG L RP+ CP ++ +M CW+Y P+ RP FLEI
Sbjct: 965 LGQGSFGMVYQGIAKDIVKGDPETR---VAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSK-GQPTLVVMELMTHGDLKSYLRSLRPDS-----ENNPSGA-----PPPSLKDMLQMAAEIADGMAYLNAKKFVHRDLAARNCMVG----EDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGFLDRPDNCPERMHSLMQMCWQYNPKMRPTFLEI 1223
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ENSORLT00000023220.2 (insulin receptor [Source:NCBI gene;Acc:101168764]) HSP 1 Score: 209.149 bits (531), Expect = 7.273e-54 Identity = 112/277 (40.43%), Postives = 164/277 (59.21%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTM--TVESDNKTSQKPVALKIRNGKSISEE--DFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G G+FGMV++G V+ D +T VA+K N + E +F EA ++ + ++V LLGV +++E M G+L+ YL+ RPD +NN + KD++ +A++I + + +L K FVHRD+AARNC+V K+GDFG+ RDIY +YYRK + +P+RWMAPE++KDG+F+ SD WSFGV+ WEI T PY G +N +VLK V+DG L RP+ CP ++ +M CW+Y P+ RP FLEI
Sbjct: 1021 LGQGSFGMVYQGIAKDIVKGDPETR---VAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSK-GQPTLVVMELMTHGDLKSYLRSLRPDS-----ENNPSGA-----PPPSLKDMLQMAAEIADGMAYLNAKKFVHRDLAARNCMVG----EDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGFLDRPDNCPERMHSLMQMCWQYNPKMRPTFLEI 1279
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000063632.1 (SMESG000063632.1) HSP 1 Score: 2758.79 bits (7150), Expect = 0.000e+0 Identity = 1378/1446 (95.30%), Postives = 1383/1446 (95.64%), Query Frame = 1
Query: 1267 VSWNQPIAKWQSKFRWKLFSYKLQLRSNQTRVSTINVNNKAHFRFYGLRPNSKYEVIVSTKHFLQSITGVTLNSKVNIAFHIFIIKNGTIKSMNFSLRTFKPKKYDSILSTLTLVKDIHMFQNCGFVLHQNGFITRLVNHSITHKLSLQNAIKMEVDFSTGNVFFIDGSNHWIYRYRIKDMLIYAIDVITPHWTDDFTLFPTLDVLFFGNVTGTYYTDLNGLSVRHSGILEIKNERLFCGDHFVEIIILRNQHRILSRFKNGSRFHCRSSALGIVMTSDSGISLRNWQGNSSLNLMRNHSGVSALSIKDSSICQDIYVKPIQAEFISISRSNSDDIVLSWIPENKDSHRSYLVFIINHNRKRHWTFSTHATTINLKNFSRCSDSIEFSIKILYKTTFSDTVTKNFHVPCTTKLPRITDLFITKKSIIGNIHRSLIEVQSEFQIYANTKKIDFQYSCVFVILFRKKFQMISEVKKSSEISCLDQKFSTSFEVDQNYQFELDEICGSISFHDISIEKCIGNEIMKTNAKEIILSRRQKYVLTYLNESINRIFIDPSGTSVSMTIDGSQFSRKILISETPVDKLEIDWIKNVLFWSERGPVEMKLFSVNLNGIKVNLREDRLLWINQDGIGFIWSIDTIERKLRITTNQNESIINLDYGPEWHVDHGYLVNCDKLINHRNILKCTNENISKNSVSAISSYFYPFKNLIIYENLNKLVCKIVTVKRNYVIPNVVSSCAVKQFSNVKNIDSSVLSLNEKTLIDGIGNVYSLSMSNNAQCNMSSIQFINLLLVKCYRNHAEVSISSSSRKHIFKLGIHYVNMESHENHSVDILDNPFNDPIQHDISINDLHPGIFYQFIFTFNFTMSKLQGIVTCQCFSKDDVPDSPVNVSILRQNFTHNRIMWKPGKTNGDNILDYKIKMNFQNHLQKFNSIKNTYFDIAKSNQTGTISVEARNIVGFSLPSYLSLKLTDTRKQISHYYLHSTMTFXXXXXXXXXXXXXXXXXXXXMYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYFDGPRDIEETSTLSRLVMRSYNSSHESEFGINSDPVTEKTSIAFSEKYPEIGSLPPPTVENVTVRKNYDNLGYEVPLSPAIITKQESVFLHYSNDAN 5604
+S N +W KFRWKLFSYKLQLRSNQTRVSTINVNNKAHFRFYGL PNSKYEVIVSTKHF QSITGVTLNSKVNI FHIFIIKNGTIKSMNFSLRTFKP+KYDSILSTLTLVKDIHMFQNCGFVLHQNGFITRLVNHSITHKLSLQNAIKMEVDFSTGNVFFIDGSNHWIYRYRIKDMLIYAIDVITPHWTDDFTLFPTLDVLFFGNVTGTYYTDLNGLSVRHSGILEIKNERLFCGDHFVEIIILRNQHR+LSRF NGSRFHCRSSALGIVMTSDSGISLRNWQGNSSLNLMRNHSGVSALSIKDSSICQDIYVKPIQAEFISISRSNSDDIVLSWIPENKDSHRSYLVFIINHNRKRHWTFSTHATTINLKNFSRCSDSIEFSIKILYKTTFSDTVTKNFHVPCTTKLPRITDLFITKKSIIGNIHRSLIEVQSEFQIYANTKKIDFQYSCVFVILFRKKFQMISEVKKSSEISCLDQKFSTSFEVDQNYQFELDEICGSISFHDISIEKCIGNEIMKTNAKEIILSRRQKYVLTYLNESINRIFIDPSG SVSMTIDGSQFSRKILISETPVDKLEIDWIKNVLFWSERGPVEMKLFSVNLNGIKVNLREDRLLWINQDGIGFIWSIDTIERKLRITTNQNESIINLDYGPEWHVDHGYLVNCDKLINHRNILKCTNENISKNSVSAISSYFYPFKNLIIYENLNKLVCKIVTVKRNYVIPNVVSSCAVKQFSNVKNIDSSVLSLNEKTLIDGIGNVYSLSMSNNAQCNMSSIQFINLLLVKCYRNHAEVSISSSSRKHIFKLGIHYVNMESHENHSVDILDNPFNDPIQHDISINDLHPGIFYQFIFTFNFTMSKLQGIVTCQCFSKDDVPDSPVNVSILRQNFTHNRIMWKPGKTNGDNILDYKIKMNFQNHLQKFNSIKNTYFDIAKSNQTGTISVEARNIVGFSLPSYLSLKLTDTRKQISHYYLHSTMTFSTSLFLIIVLVSVSLILIISMYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCL + GKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYFDGPRDIEETSTLSRLVMRSYNSSHESEFGINSDPVTEKTSIAFSEKYPEIGSLPPPTVENVTVRKNYDNLGYEVPLSPAIITKQESVFLHYSNDAN
Sbjct: 110 LSNNDDKRQWVGKFRWKLFSYKLQLRSNQTRVSTINVNNKAHFRFYGLWPNSKYEVIVSTKHFSQSITGVTLNSKVNIDFHIFIIKNGTIKSMNFSLRTFKPEKYDSILSTLTLVKDIHMFQNCGFVLHQNGFITRLVNHSITHKLSLQNAIKMEVDFSTGNVFFIDGSNHWIYRYRIKDMLIYAIDVITPHWTDDFTLFPTLDVLFFGNVTGTYYTDLNGLSVRHSGILEIKNERLFCGDHFVEIIILRNQHRMLSRFNNGSRFHCRSSALGIVMTSDSGISLRNWQGNSSLNLMRNHSGVSALSIKDSSICQDIYVKPIQAEFISISRSNSDDIVLSWIPENKDSHRSYLVFIINHNRKRHWTFSTHATTINLKNFSRCSDSIEFSIKILYKTTFSDTVTKNFHVPCTTKLPRITDLFITKKSIIGNIHRSLIEVQSEFQIYANTKKIDFQYSCVFVILFRKKFQMISEVKKSSEISCLDQKFSTSFEVDQNYQFELDEICGSISFHDISIEKCIGNEIMKTNAKEIILSRRQKYVLTYLNESINRIFIDPSGRSVSMTIDGSQFSRKILISETPVDKLEIDWIKNVLFWSERGPVEMKLFSVNLNGIKVNLREDRLLWINQDGIGFIWSIDTIERKLRITTNQNESIINLDYGPEWHVDHGYLVNCDKLINHRNILKCTNENISKNSVSAISSYFYPFKNLIIYENLNKLVCKIVTVKRNYVIPNVVSSCAVKQFSNVKNIDSSVLSLNEKTLIDGIGNVYSLSMSNNAQCNMSSIQFINLLLVKCYRNHAEVSISSSSRKHIFKLGIHYVNMESHENHSVDILDNPFNDPIQHDISINDLHPGIFYQFIFTFNFTMSKLQGIVTCQCFSKDDVPDSPVNVSILRQNFTHNRIMWKPGKTNGDNILDYKIKMNFQNHLQKFNSIKNTYFDIAKSNQTGTISVEARNIVGFSLPSYLSLKLTDTRKQISHYYLHSTMTFSTSLFLIIVLVSVSLILIISMYIHHRKTKRNNKLIKSNIIVDAQTFELMNVNQGIKYEINSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLEN-------------------------------------------------HGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYFDGPRDIEETSTLSRLVMRSYNSSHESEFGINSDPVTEKTSIAFSEKYPEIGSLPPPTVENVTVRKNYDNLGYEVPLSPAIITKQESVFLHYSNDAN 1506
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000063625.1 (SMESG000063625.1) HSP 1 Score: 713.761 bits (1841), Expect = 0.000e+0 Identity = 383/388 (98.71%), Postives = 385/388 (99.23%), Query Frame = 1
Query: 142 VWPLSGIIIADNQRSFSVISIESINIKTVRIEWKIEEKLIKQLHMFNLVACINTSAERNYNYLPTMRSLVMYNVSIECNRNELYAVFTDLSTLGCIFYLHHLNAIYTVDNQFFGCFKDDCDFXXXXXXXXXXXXXYGKSLYDFYIYTRSALEWHDFRSTKFTILALRISDPIIKMDFDWLNELVLILTPSKIYQINIKNKSITHARITTNFSSIDAVADPINGLIHMLMQHNSSRFYTTLHSTILENISFSNLKSTTLEIPDSCSLILASDGTSIKILQSNSLLTFQLKKMVLVKDFDLRNANFQPPVKLQLKQDTYVVWKXXXXXXXXXXXXXXXXXXSRMDHYASAKSINRNSPTPLISFVILNSFYGDNFLFVSWNQPIAKWQSK 1305
VWPLSGIIIADNQRSFSVISIESINIKTVRIEWKIEEKLIKQLHMFNLVACINTSAERNYNYLPTMRSLVMYNVSIECNRNELYAVFTDLSTLGCIFYLHH NAIYTVDNQFFGCFKDDCDFLLLNASSSILAISYGKSLYDFYIYTRSALEWHDFRSTKFTILALRISDPIIKMDFDWLNELVLILTPSKIYQINIKNKSITHARITTNF+SIDAVADPINGLIH+LMQHNSSRFYTTLHSTILENIS SNLKSTTLEIPDSCSLILASDGTSIKILQSNSL TFQLKKMVLVKDFDLRNANFQPPVKLQLKQDTYVVWKTNVNFEFNENNTNVHTFHSRMDHYASAKSINRNSPTPLISFVILNSFYGDNFLFVSWNQPIAKWQSK
Sbjct: 14 VWPLSGIIIADNQRSFSVISIESINIKTVRIEWKIEEKLIKQLHMFNLVACINTSAERNYNYLPTMRSLVMYNVSIECNRNELYAVFTDLSTLGCIFYLHHFNAIYTVDNQFFGCFKDDCDFLLLNASSSILAISYGKSLYDFYIYTRSALEWHDFRSTKFTILALRISDPIIKMDFDWLNELVLILTPSKIYQINIKNKSITHARITTNFTSIDAVADPINGLIHILMQHNSSRFYTTLHSTILENISISNLKSTTLEIPDSCSLILASDGTSIKILQSNSLSTFQLKKMVLVKDFDLRNANFQPPVKLQLKQDTYVVWKTNVNFEFNENNTNVHTFHSRMDHYASAKSINRNSPTPLISFVILNSFYGDNFLFVSWNQPIAKWQSK 401
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000041792.1 (SMESG000041792.1) HSP 1 Score: 186.037 bits (471), Expect = 1.311e-47 Identity = 109/309 (35.28%), Postives = 170/309 (55.02%), Query Frame = 1
Query: 4387 NSLYGFEKLPLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNK----TSQKPVALKIRNGKSIS-EEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKM-PIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+SL K+ +T+ D + L++ + + IG G FG V+K + ++N S + + G S+ + +FK+EA ++ + H N++ L+GVS CLI ++MEKG+L + L + +R + + L D I IA+ I +++L ++FVHRD+AARN L+ + K+ D GL +D Y +YYR T T M PIRWM+PE I G F+ +SDVW++GVL WEI + G P+ G +NAEV++ V + L P+ CP VY++ML+CW P RP+F I
Sbjct: 458 SSLVQLNKIKITSTD---YPLSQ-IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIR-QIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIG----ENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNI 757
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000042606.1 (SMESG000042606.1) HSP 1 Score: 181.8 bits (460), Expect = 5.034e-46 Identity = 103/273 (37.73%), Postives = 146/273 (53.48%), Query Frame = 1
Query: 4477 IGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLILEYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPETCPIDVYEMMLQCWKYYPECRPRFLEI 5295
+G+G +G+V++ K VA+K +DF EA L+ HPN+V LLGV P +I E+ME GNL +YL R + K + L L+ +A I +++LE+ NF+HRD+AARNCLV N I K+ DFGLAR + D+ Y K PI+W APE + FS KSDVW+FGVL WE+ T+G PY G +V + G + RP CP ++Y++M QCW+++PE RP F ++
Sbjct: 261 LGSGQYGIVYEAFW------KKYSITVAVKTVKTDITVADDFLEEARLMKSLQHPNLVRLLGVCTQEP-PNYIIAEFMENGNLLEYL--------RTRSKED-----------LPPPVLLYMAIQIAAGMEYLEQHNFIHRDLAARNCLVGQDN----IVKVADFGLARCMERDDTYTAHVGAKFPIKWTAPEGLAYNQFSTKSDVWAFGVLLWELATYGMTPYPGIELQDVYVYLEKGNIMNRPAGCPDNIYDIMKQCWQWFPESRPSFKDL 503
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000045588.1 (SMESG000045588.1) HSP 1 Score: 175.252 bits (443), Expect = 6.178e-46 Identity = 112/307 (36.48%), Postives = 157/307 (51.14%), Query Frame = 1
Query: 4414 PLTNFDKIPHILNECLNYSHLIGNGAFGMVFKGTMTVESDNKTSQKPVALKIRNGKSISEEDFKREAVLLFKYGHPNIVILLGVSFDCPDKQCLIL-EYMEKGNLRQYLQHHRPDVIRQKLKNNSTKRLINENSILDTKDLISIASDILEALKFLEEKNFVHRDIAARNCLVSIHNKNKRITKLGDFGLARDIYFDEYYRKTSETKMPIRWMAPETIKDGIFSGKSDVWSFGVLCWEIMTFGADPYMGQTNAEVLKDVIDGKQLGRPE----TCPIDVYEMMLQCWKYYPECRPRFLEIDLIFQYFD 5319
P F I + +C+ ++GNG+FG V+ G + VA+K S+ F EA L+ K HP IV +LGV P++ I+ E M G L YL+ P+ QKL+ N +++ + S I E + +LE +NFVHRD+ A N LV K+ DFGLAR D+ Y + TK PI+W APE FS KSDVWSFGVL +EI+T+G PY G N +VL +V G +L P CP ++Y + L+CW YPE RP F + IF++++
Sbjct: 235 PPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVE-------VAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLR--SPE--GQKLRLN---------------EMLDMMSQIAEGMAYLESRNFVHRDLRAANILVD----EDLSVKVADFGLAR--VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWE 508 The following BLAST results are available for this feature:
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004366 ID=SMED30004366|Name=Tyrosine-protein kinase receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=5654bpback to top protein sequence of SMED30004366-orf-1 >SMED30004366-orf-1 ID=SMED30004366-orf-1|Name=SMED30004366-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1835bp MLLLASFCFLAASVWPLSGIIIADNQRSFSVISIESINIKTVRIEWKIEEback to top Annotated Terms
The following terms have been associated with this transcript:
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