Bestrophin homolog
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004353 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105]) HSP 1 Score: 283.108 bits (723), Expect = 2.777e-89 Identity = 146/389 (37.53%), Postives = 219/389 (56.30%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDM--KVDSNDW 1268
MTV Y +V +A F +LL KW+G ++KL+Y +FIVF+ LYT IS +YRL+L KR FEK+ Y + IPV F+LGFYV+LV NR+W F +PW ++ +I+S S+ E RL RR+++RY+ + ++ VS V +RFP +D + G + E ++ + + ++ ++P W + KA +GRI + L + + E+N++R LF D V +PLVYTQVVTLAVY++F +CLIGRQF+ + D +PIFT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + + P + KD ++D P D F+GS M ++ N+W
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISS--------------SVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTVQMGKQMPKNEW 375
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105]) HSP 1 Score: 287.73 bits (735), Expect = 6.232e-88 Identity = 145/386 (37.56%), Postives = 217/386 (56.22%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MTV Y +V +A F +LL KW+G ++KL+Y +FIVF+ LYT IS +YRL+L KR FEK+ Y + IPV F+LGFYV+LV NR+W F +PW ++ +I+S S+ E RL RR+++RY+ + ++ VS V +RFP +D + G + E ++ + + ++ ++P W + KA +GRI + L + + E+N++R LF D V +PLVYTQVVTLAVY++F +CLIGRQF+ + D +PIFT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + + P + KD ++D P D F+GS M + +D
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISS--------------SVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTVQMGLSGSD 372
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107]) HSP 1 Score: 266.159 bits (679), Expect = 2.204e-81 Identity = 156/464 (33.62%), Postives = 236/464 (50.86%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELP-MESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTIS 1496
MTV Y V +A F +LL W+G ++KL++ + + F Y +S YR +L + KR FEK+V Y Q SLIPV+F+LGFYV+LV NR+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W + + +A +GRI + + L ++E+N FR LF D + VPLVYTQVVT+A+YSYFL+CLIGRQF+ + + D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + + R F GS +D+ + D G GE D L + L G+ + S +K + + + S A + E P S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQPSFQGSTFDITLAKEDMQFQRLDGLDGPMGEAPGDFLQ-RLLPAGAGMVAGGPLGRRLSFLLRKNSCVSEASTGASCSCAVVP--EGAAPECS 447
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107]) HSP 1 Score: 266.159 bits (679), Expect = 2.204e-81 Identity = 156/464 (33.62%), Postives = 236/464 (50.86%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELP-MESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTIS 1496
MTV Y V +A F +LL W+G ++KL++ + + F Y +S YR +L + KR FEK+V Y Q SLIPV+F+LGFYV+LV NR+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W + + +A +GRI + + L ++E+N FR LF D + VPLVYTQVVT+A+YSYFL+CLIGRQF+ + + D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + + R F GS +D+ + D G GE D L + L G+ + S +K + + + S A + E P S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQPSFQGSTFDITLAKEDMQFQRLDGLDGPMGEAPGDFLQ-RLLPAGAGMVAGGPLGRRLSFLLRKNSCVSEASTGASCSCAVVP--EGAAPECS 447
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107]) HSP 1 Score: 266.159 bits (679), Expect = 2.204e-81 Identity = 156/464 (33.62%), Postives = 236/464 (50.86%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELP-MESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTIS 1496
MTV Y V +A F +LL W+G ++KL++ + + F Y +S YR +L + KR FEK+V Y Q SLIPV+F+LGFYV+LV NR+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W + + +A +GRI + + L ++E+N FR LF D + VPLVYTQVVT+A+YSYFL+CLIGRQF+ + + D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + + R F GS +D+ + D G GE D L + L G+ + S +K + + + S A + E P S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQPSFQGSTFDITLAKEDMQFQRLDGLDGPMGEAPGDFLQ-RLLPAGAGMVAGGPLGRRLSFLLRKNSCVSEASTGASCSCAVVP--EGAAPECS 447
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-3 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17206]) HSP 1 Score: 239.58 bits (610), Expect = 1.124e-70 Identity = 130/388 (33.51%), Postives = 215/388 (55.41%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVN----VETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFE--LPMESNMKDARAKPFMGSVYDMKVD 1256
MTV Y +V S+ KLL +WKG ++K ++ + +V+ LY ++S IYR +L + + FE + + + IP+ F+LGFYVS VF R+W+ F+ + WI + I + I+ + E A+ RR+ IRY + + V+ V++RFP + + G++ E E ++ + + P+ W +++ A +G I+++ + ++ ++++ +FR + L L D V VPLVYTQVV LAV SYFL L GRQ++ N + T D VPI ++LQFI ++GW+K+A L+NP+GEDD+DF+ N ++D N ++GL + D P L KD+F++ + E ES M+ P +GS DM +
Sbjct: 1 MTVTYSLDVASSSFFCLYKLLFRWKGSIWKSVWAELVVWLCLYAVLSVIYRCLLTMKQRATFEDLCIFFDTYSNFIPITFMLGFYVSAVFTRWWQIFDNIGWIDTPCLWITQY--------------IKGETERAKCVRRNCIRYSILTQAMVYRDVAASVRKRFPTFNHLVTAGLMTEKEMAEFESIPSPHAKYWQPMHWLFSMITLARDEGMISSDIIYVDLMEKMRQFRVNILSLTLFDWVPVPLVYTQVVHLAVRSYFLIALFGRQYLHPESNRLNDFKQTIDLYVPIMSLLQFIFFIGWMKVAEVLLNPLGEDDDDFECNWILDRNLQVGLMVVDTAYNRYPTLEKDQFWEDAIAEPLYTAESAMRP--LNPQVGSCADMPTE 372
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-24 (Bestrophin homolog 24 [Source:UniProtKB/Swiss-Prot;Acc:P34672]) HSP 1 Score: 238.424 bits (607), Expect = 4.121e-70 Identity = 128/382 (33.51%), Postives = 211/382 (55.24%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIM-DSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV 1253
MT+ Y V ++ P KLL KW+G ++K + ++ V+ LY ++S IYR L +R FE++V Y S IP+ F+LGF+V+ V NR+ + + +I I +M A E +R E+AR+ RR+I+RY + ++ +S+ +RRFP +D + G ++ HE + + + ++P W+ ++ +A +G I ++ + EI KFR L + D V +P++Y Q+V LAV++YFL CL+ RQ+++ + + +T D PI + LQFI YMGW+K+A ++NP GEDD+DF+ N ++D N + L + D P L +D F+D++V L E K P GSV D+K+
Sbjct: 1 MTINYNLAVSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAA--------------EYVRGRTEQARMYRRNIVRYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAPDLKRDDFWDEEVEPLYSEETAK-IPNNPLKGSVSDVKL 367
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-4 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17205]) HSP 1 Score: 235.728 bits (600), Expect = 7.710e-70 Identity = 131/384 (34.11%), Postives = 219/384 (57.03%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHE-AEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ---DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFM-GSVYDM 1247
MTV Y +V ++G +K+L +WKG V+K I+ + +++ Y+++S IYR++L + FE++ ++ IPV F+LGFYVS+V+NR+ + F+ V WI A+ IA + IR E+ARL RR+ +RY+ + ++ VS ++RRFP I + G+L E E E T P + + + PI W ++V A +G I + + ++ + ++ +FR + L + D V +PLVYTQVV LAV +YF+ L GRQF+ ++ N+ + D PI T LQ + +GWLK++ ++NP+GEDDEDF+ N +++ N ++G A+ D P L +D F++ + + M++ +A M GS +M
Sbjct: 1 MTVAYSLDVATSGLFTQIKVLLRWKGSVWKSIWSELLIWLLCYSILSVIYRILLNKAQREVFEQLCTFFDTFSVFIPVTFMLGFYVSIVYNRWTKVFDNVGWIDTSALTIAQY--------------IRGTSEKARLIRRNCVRYMIVAQVMVFRDVSPAIRRRFPTIKHLIGAGLLTEDELTEFDAITSPQS-KYWQPIQWLFSLVTVAKDEGLIADSYLYVDLIDKMREFRTKILNLVIFDMVPIPLVYTQVVNLAVRTYFVLALFGRQFLENNNNIPGAKWKIDIYFPIMTSLQIVFIVGWLKVSEVMLNPLGEDDEDFETNWIIERNLQVGYAVVDQAYGRYPTLKRDPFWEDETPQT-MDTPTSTRKAHSHMQGSCINM 368
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369]) HSP 1 Score: 232.261 bits (591), Expect = 3.193e-69 Identity = 131/387 (33.85%), Postives = 213/387 (55.04%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQS-QSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFF--DKKVFELPMESNMKDARAKPFMGSVYDMKVDSN 1262
MT+ Y +V +F LL +W+G V+K ++ V+++++ +ISCIYR +L + FE+++ Y + IP+ F+LGF+VS V R+ N + WI +++ A++ IR EE R+ RR+++RYL S + L +S+ V++RFP +D + G++ E +I+ + + + + I WS +V + +G++ + ++ V EI KFR L L D V VPLVY QV+ LAV YF+ CLIGRQFI+ N + D +PI T++QF+VYMGW+K+A L+NP+GEDD+D + N ++D N G ++ + P KD+F+ DK MES + P +GS + + N
Sbjct: 1 MTISYTLDVSQTNLQSFFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIRYFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATY--------------IRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPN-PSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGYSMVEEHMAKTPAQKKDEFWGIDKIAPLYSMES--AERSVHPLVGSASKINLVKN 370
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369]) HSP 1 Score: 231.876 bits (590), Expect = 5.259e-69 Identity = 131/387 (33.85%), Postives = 213/387 (55.04%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQS-QSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFF--DKKVFELPMESNMKDARAKPFMGSVYDMKVDSN 1262
MT+ Y +V +F LL +W+G V+K ++ V+++++ +ISCIYR +L + FE+++ Y + IP+ F+LGF+VS V R+ N + WI +++ A++ IR EE R+ RR+++RYL S + L +S+ V++RFP +D + G++ E +I+ + + + + I WS +V + +G++ + ++ V EI KFR L L D V VPLVY QV+ LAV YF+ CLIGRQFI+ N + D +PI T++QF+VYMGW+K+A L+NP+GEDD+D + N ++D N G ++ + P KD+F+ DK MES + P +GS + + N
Sbjct: 1 MTISYTLDVSQTNLQSFFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIRYFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATY--------------IRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPN-PSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGYSMVEEHMAKTPAQKKDEFWGIDKIAPLYSMES--AERSVHPLVGSASKINLVKN 370
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183) HSP 1 Score: 293.893 bits (751), Expect = 4.034e-90 Identity = 150/369 (40.65%), Postives = 227/369 (61.52%), Query Frame = 3
Query: 111 MTVQYYQEVLSA-GPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTE---PFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ----DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVF--ELP 1187
MT+ Y EV + G FLKLL +W+G ++KL+++D + F ++Y I+ +YR L K FE +V Y + LIP++F+LGFYVS+V R+W + ++PW IA+ ++S+++ G D E R+ RR+I+RY+ L + L+ VS VK+RFP ++ + G+L ++E II+ P + +LPI W+A+I+ +A +GRI ++ + + E+NKFR L D + VPLVYTQVVTLAVYSYFL+C +G+Q+ V TT D P+FT LQF YMGWLK+A +L+NP GEDD+DF++N +VD N ++ I D + D P L+KD+++D +VF ELP
Sbjct: 1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVH-------GQD-------ERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD-EVFPNELP 354
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020) HSP 1 Score: 293.508 bits (750), Expect = 8.483e-90 Identity = 150/369 (40.65%), Postives = 227/369 (61.52%), Query Frame = 3
Query: 111 MTVQYYQEVLSA-GPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTE---PFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ----DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVF--ELP 1187
MT+ Y EV + G FLKLL +W+G ++KL+++D + F ++Y I+ +YR L K FE +V Y + LIP++F+LGFYVS+V R+W + ++PW IA+ ++S+++ G D E R+ RR+I+RY+ L + L+ VS VK+RFP ++ + G+L ++E II+ P + +LPI W+A+I+ +A +GRI ++ + + E+NKFR L D + VPLVYTQVVTLAVYSYFL+C +G+Q+ V TT D P+FT LQF YMGWLK+A +L+NP GEDD+DF++N +VD N ++ I D + D P L+KD+++D +VF ELP
Sbjct: 1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVH-------GQD-------ERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD-EVFPNELP 354
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590) HSP 1 Score: 293.893 bits (751), Expect = 1.461e-89 Identity = 150/369 (40.65%), Postives = 227/369 (61.52%), Query Frame = 3
Query: 111 MTVQYYQEVLSA-GPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTE---PFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ----DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVF--ELP 1187
MT+ Y EV + G FLKLL +W+G ++KL+++D + F ++Y I+ +YR L K FE +V Y + LIP++F+LGFYVS+V R+W + ++PW IA+ ++S+++ G D E R+ RR+I+RY+ L + L+ VS VK+RFP ++ + G+L ++E II+ P + +LPI W+A+I+ +A +GRI ++ + + E+NKFR L D + VPLVYTQVVTLAVYSYFL+C +G+Q+ V TT D P+FT LQF YMGWLK+A +L+NP GEDD+DF++N +VD N ++ I D + D P L+KD+++D +VF ELP
Sbjct: 1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVH-------GQD-------ERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD-EVFPNELP 354
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0306023) HSP 1 Score: 293.123 bits (749), Expect = 3.004e-89 Identity = 150/369 (40.65%), Postives = 227/369 (61.52%), Query Frame = 3
Query: 111 MTVQYYQEVLSA-GPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTE---PFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ----DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVF--ELP 1187
MT+ Y EV + G FLKLL +W+G ++KL+++D + F ++Y I+ +YR L K FE +V Y + LIP++F+LGFYVS+V R+W + ++PW IA+ ++S+++ G D E R+ RR+I+RY+ L + L+ VS VK+RFP ++ + G+L ++E II+ P + +LPI W+A+I+ +A +GRI ++ + + E+NKFR L D + VPLVYTQVVTLAVYSYFL+C +G+Q+ V TT D P+FT LQF YMGWLK+A +L+NP GEDD+DF++N +VD N ++ I D + D P L+KD+++D +VF ELP
Sbjct: 1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVH-------GQD-------ERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD-EVFPNELP 354
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best4 (gene:FBgn0036491 transcript:FBtr0113172) HSP 1 Score: 281.952 bits (720), Expect = 1.261e-87 Identity = 148/388 (38.14%), Postives = 234/388 (60.31%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVA-FLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTE---PFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDS 1259
MTV Y V ++ ++ FL LL +W+G ++KLI++D IVF LY +++ YRL++ +E KR FE ++SY ++ SLIP++F+LGF+V +V NR+W + T+PW IAI+I++ SI + AR+ RR+I+RY+ +I + +S VKRRFP +I G LLE+E +II+ + P + ++PI W+A+IVM+A + +I ++ + + E+N+ R L D + VPLVYTQVVT+A YS+FL ++G+Q+ + + T+ PI T+LQF YMGWLK+A TL+NP GEDD+DF+LN ++D N + I D + + P L+KD++++ +VF + R P S M+ S
Sbjct: 1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILIST--------------SIHGSDDRARVMRRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQWNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHPELVKDQYWE-EVFPNEIPYAQPKMRQNPPAASTAYMESQS 373
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214]) HSP 1 Score: 294.278 bits (752), Expect = 1.548e-90 Identity = 153/426 (35.92%), Postives = 237/426 (55.63%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRS 1385
MTV Y + V A F +LL +WKG ++KL+Y + ++F+ +Y +IS YR +L +E +R FEK+ Y Q LIPV+F+LGFYV+LV +R+W F +VPW +++ +++ H +R E ARL RRS++RY S I+ VS V +RFP + + G++ E ++ + ++P W ++ M+A ++GRI N+ + + E+N R L+ D + +PLVYTQVVT+AVYS+FL+CLIGRQF+ + DF +P+FT+LQF Y+GWLK+A L+NP GEDD+DF+ N +VD N ++ L D + P + +DK++D+ + P + + R FMGS D+ V + I E + ++ SL GV N RS
Sbjct: 1 MTVTYSRRVADARLGTFYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGH--------------VRGADEGARLIRRSLMRYANLSGILIYRSVSTAVYKRFPTMSHLVQAGLMTAEELRQLQELPSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERDKYWDEAEPQPPYTAASAEHRKPSFMGSALDISVPKEEMEFQHNLEQIKEHEEANHSTPFLGSLSRLLGVQSPNFPRS 412
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127]) HSP 1 Score: 266.929 bits (681), Expect = 1.099e-82 Identity = 147/385 (38.18%), Postives = 213/385 (55.32%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILG--FYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKV 1253
MTV Y V +A F KLL WKG ++K++Y +F+ F ++YT IS YR L D KR FEK+ Y SLIP++F+LG FYV+LV NR+W + ++P ++ M +S G DE RL RR+++RY + S ++ L VS V +RFP ID + G + E + ++ + ++P W + A +GRI ++ ++E+N FR LF D + VPLVYTQVVTLAVYS+FL CLIGRQF+ D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D P + +D++++ P + KP F GS +DM +
Sbjct: 1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRV-------MCVLSGGVQGSDE-------RGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPGQGYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPMMERDRYWNDSNPRPPYTAATLFVLRKPSFQGSTFDMTI 371
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6]) HSP 1 Score: 252.292 bits (643), Expect = 3.900e-78 Identity = 134/380 (35.26%), Postives = 216/380 (56.84%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDM 1247
MTV Y +V +A F KLL +WKG ++KL+Y +F+VF LYT IS +YR +L + + F ++ + + LIP++F+LGFYV+ F R+W + + P + ++++ +++ G DE RL RR+++RY S ++ L +S V++RF +++I G + E + + + ++P+ W A + +A +GR+ ++ L + E+N +R LF D + +PLVYTQVVT+AVYS+F LIGRQF+ + E D +PIFT+L+F Y GWLK+ ++NP GEDD+DF+ N ++D N ++ + D + + PPL KDK++ K P A KP FMGS +DM
Sbjct: 1 MTVSYTLKVANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVH-------GTDE-------RGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFV-KPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLPPLEKDKYWVDKGPSYP------SASMKPVFMGSTHDM 359
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6]) HSP 1 Score: 228.409 bits (581), Expect = 2.426e-69 Identity = 116/330 (35.15%), Postives = 192/330 (58.18%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEI 1100
MTV Y +V +A F KLL +WKG ++KL+Y +F+VF LYT IS +YR +L + + F ++ + + LIP++F+LGFYV+ F R+W + + P + ++++ +++ G DE RL RR+++RY S ++ L +S V++RF +++I G + E + + + ++P+ W A + +A +GR+ ++ L + E+N +R LF D + +PLVYTQVVT+AVYS+F LIGRQF+ + E D +PIFT+L+F Y GWLK+ ++NP GEDD+DF+ N ++D N ++
Sbjct: 1 MTVSYTLKVANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVH-------GTDE-------RGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFV-KPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQV 315
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214]) HSP 1 Score: 164.466 bits (415), Expect = 2.377e-45 Identity = 85/231 (36.80%), Postives = 129/231 (55.84%), Query Frame = 3
Query: 696 FLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRS 1385
++P W ++ M+A ++GRI N+ + + E+N R L+ D + +PLVYTQVVT+AVYS+FL+CLIGRQF+ + DF +P+FT+LQF Y+GWLK+A L+NP GEDD+DF+ N +VD N ++ L D + P + +DK++D+ + P + + R FMGS D+ V + I E + ++ SL GV N RS
Sbjct: 22 WVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERDKYWDEAEPQPPYTAASAEHRKPSFMGSALDISVPKEEMEFQHNLEQIKEHEEANHSTPFLGSLSRLLGVQSPNFPRS 252
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: ifitm3 (interferon induced transmembrane protein 3 [Source:Xenbase;Acc:XB-GENE-5852510]) HSP 1 Score: 283.108 bits (723), Expect = 2.815e-86 Identity = 148/394 (37.56%), Postives = 225/394 (57.11%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ--DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV-DS----NDWI 1271
MTV Y +V +A F +LL KW+G ++KL+Y +F++F+SLYT +S IYR L D KR FEKV Y + IPV F+LGFYV+LV NR+W F +PW ++ +I+S+++ G DE RL RR+++RY+ + ++ VS V +RFP +D + G + E ++ + + ++ ++P+ W + KA ++GRI + L + E+NKFR LF D V +PLVYTQVVTLAVY++F +C+IGRQF +D D +P+FT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + ++ P + +D +++ P D F+GS M + DS DW+
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFLLFTSLYTTLSVIYRFFLTDSQKRYFEKVSMYCDKYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSNVH-------GRDEY-------GRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTSDERKLFDSLKSPHLKYWVPVIWFGNLASKARSEGRIRDSIDLQMMMNEMNKFRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQF-LDPKQAYPGHDLDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLMAVDEMHMNLPKMNRDIYWNDSDVRPPYTLAAADYCIPSFLGSTVHMGLPDSVFLREDWL 379
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: cyp2b6 (cytochrome P450 family 2 subfamily B member 6 [Source:Xenbase;Acc:XB-GENE-5779150]) HSP 1 Score: 277.33 bits (708), Expect = 1.308e-85 Identity = 146/382 (38.22%), Postives = 220/382 (57.59%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMK 1250
MTV Y +V +A F KLL +WKG ++KL+Y +FIVF LY M+S YR +L ++ K +F ++ Y Q LIPV+F+LGFYV+L+ NR+W + +P ++ +++S++ + GD E RL RR+++RY S ++ L VS V +RFP ++ I G + E + + + ++P W + +A GR+ ++ L + E+NK+R LF D + VPLVYTQVVT+AVYS+F C+IGRQF+ + E D VPIFT+LQF Y GWLK+A ++NP GEDD+DF+ N ++D N ++ L D + + PPL KDK++D + P KP FMGS +DM+
Sbjct: 1 MTVSYTLKVANASFGCFFKLLFRWKGSIYKLLYKEFIVFCCLYAMLSVTYRCLLNEKQKSEFAQLARYCNQYTDLIPVSFVLGFYVTLIVNRWWAQYTNIPLPDQLMCVVSSNV------HGGD--------ERGRLLRRTMMRYANLSSVLILRSVSTRVLKRFPTMEHIVEAGFMTREELKKYECLFSDYNKYWIPCVWFTNLAAQARRDGRVRDDVALKLLMDELNKYRAKCSMLFHYDWISVPLVYTQVVTIAVYSFFGVCIIGRQFLEPELEEEKPNIDLYVPIFTLLQFFFYSGWLKVAQQIINPFGEDDDDFETNRLIDRNLQVSLLSVDDMYQNLPPLEKDKYWDDQTAAPPYTLATAAETLKPSFMGSAFDMR 368
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038]) HSP 1 Score: 271.166 bits (692), Expect = 6.374e-85 Identity = 139/382 (36.39%), Postives = 219/382 (57.33%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV 1253
MTV Y V A F +LL +W+G ++KL+Y +F++F S Y +IS YR +L ++ + FEK+ Y LIPV+F+LGFYV+LV +R+W + +VPW ++ +++S+++ G D E R+ RR+++RY + ++ L VS V RFP + + N G + E + ++P W A + + A ++GRI + VL +KE+N R L+ D + VPLVYTQVVT+AVYS+FL+CLIGRQF+ D VP+FT+LQF Y GWLK+A L+NP G+DD+DF+ N ++D N ++ L D + D PPL KD +++ + P ++ + R + GS +D+++
Sbjct: 1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVH-------GTD-------ERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWNDSDPQPPYTASTVETRRPSYQGSAFDIRI 368
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038]) HSP 1 Score: 270.011 bits (689), Expect = 1.194e-83 Identity = 139/380 (36.58%), Postives = 217/380 (57.11%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDM 1247
MTV Y V A F +LL +W+G ++KL+Y +F++F S Y +IS YR +L ++ + FEK+ Y LIPV+F+LGFYV+LV +R+W + +VPW ++ +++S+++ G D E R+ RR+++RY + ++ L VS V RFP + + N G + E + ++P W A + + A ++GRI + VL +KE+N R L+ D + VPLVYTQVVT+AVYS+FL+CLIGRQF+ D VP+FT+LQF Y GWLK+A L+NP G+DD+DF+ N ++D N ++ L D + D PPL KD +++ + P ++ + R + GS +D+
Sbjct: 1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVH-------GTD-------ERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWNDSDPQPPYTASTVETRRPSYQGSAFDI 366
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038]) HSP 1 Score: 274.633 bits (701), Expect = 1.200e-83 Identity = 140/386 (36.27%), Postives = 219/386 (56.74%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MTV Y V A F +LL +W+G ++KL+Y +F++F S Y +IS YR +L ++ + FEK+ Y LIPV+F+LGFYV+LV +R+W + +VPW ++ +++S+++ G D E R+ RR+++RY + ++ L VS V RFP + + N G + E + ++P W A + + A ++GRI + VL +KE+N R L+ D + VPLVYTQVVT+AVYS+FL+CLIGRQF+ D VP+FT+LQF Y GWLK+A L+NP G+DD+DF+ N ++D N ++ L D + D PPL KD +++ + P ++ + R + GS +D+ + D
Sbjct: 1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVH-------GTD-------ERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWNDSDPQPPYTASTVETRRPSYQGSAFDISLQKED 372
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best3 (bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298]) HSP 1 Score: 288.115 bits (736), Expect = 2.757e-88 Identity = 156/439 (35.54%), Postives = 236/439 (53.76%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVN-VETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVD-----SNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNS---NRSQKSMF 1400
MTV Y +V +A F +LL KW+G ++KL+Y +FIVF+ LYT IS +YRL+L KR FEK+ Y + IPV F+LGFYV+LV NR+W F +PW ++ ++I+S S+ + RL RR+++RY+ + ++ VS V +RFP +D + G + E ++ + + ++ ++P W + KA +GRI + L + + E+N++R LF D V +PLVYTQVVTLAVY++F +CLIGRQF+ + V D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + + P + KD ++D P D F+GS M + + DW+ + + +R K ++ + E R S S SMF
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISS--------------SVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTIQMGLSGSNFPAEDWLWNYEKHG-NRHSVMRRVKRFLSTHEHPGSPRRRRSFGRQASDSSMF 424
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332]) HSP 1 Score: 274.633 bits (701), Expect = 5.951e-86 Identity = 140/386 (36.27%), Postives = 225/386 (58.29%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MT+ Y +V +A +F LL W+G ++KL+Y +F+VF LY I +YR++L + + FEK+ Y LIP++F+LGFYV+LV +R+W + +PW ++ I ++S + G DE E RL RR++IRY ++ L +S V +RFP + + G + E + ++ ++P W A + MKA GRI + +L + + E+ R +L+ D + +PLVYTQVVT+AVYS+FL+CLIGRQF+ + + + D VVP+FTILQF+ YMGWLK+A L+NP GEDD+DF+ N ++D N ++ L DG+ + PP+ +D ++++ + P + +R FMGS +++ + D
Sbjct: 1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVE-------GKDE-------EGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPPMERDMYWNEAAPQPPYTAASARSRRHSFMGSTFNISLKKED 372
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332]) HSP 1 Score: 276.174 bits (705), Expect = 6.276e-85 Identity = 140/386 (36.27%), Postives = 225/386 (58.29%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MT+ Y +V +A +F LL W+G ++KL+Y +F+VF LY I +YR++L + + FEK+ Y LIP++F+LGFYV+LV +R+W + +PW ++ I ++S + G DE E RL RR++IRY ++ L +S V +RFP + + G + E + ++ ++P W A + MKA GRI + +L + + E+ R +L+ D + +PLVYTQVVT+AVYS+FL+CLIGRQF+ + + + D VVP+FTILQF+ YMGWLK+A L+NP GEDD+DF+ N ++D N ++ L DG+ + PP+ +D ++++ + P + +R FMGS +++ + D
Sbjct: 1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVE-------GKDE-------EGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPPMERDMYWNEAAPQPPYTAASARSRRHSFMGSTFNISLKKED 372
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588]) HSP 1 Score: 273.092 bits (697), Expect = 3.060e-84 Identity = 155/442 (35.07%), Postives = 235/442 (53.17%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNV-ETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSS 1430
MTV Y V +A F +LL W+G ++KL++ + + F LY +S YR +L +E KR FEK+V Y Q SLIPV+F+LGFYV+LV +R+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W +++ +A +GRI + + L ++E+N FR LF D + +PLVYTQVVT+AVYSYFL+CLIGRQF+ + + T D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + +P F GS +D+ + D G GE+ D ++Q L S R + K +S +S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGD--FLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEAS 426
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588]) HSP 1 Score: 273.092 bits (697), Expect = 3.060e-84 Identity = 155/442 (35.07%), Postives = 235/442 (53.17%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNV-ETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSS 1430
MTV Y V +A F +LL W+G ++KL++ + + F LY +S YR +L +E KR FEK+V Y Q SLIPV+F+LGFYV+LV +R+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W +++ +A +GRI + + L ++E+N FR LF D + +PLVYTQVVT+AVYSYFL+CLIGRQF+ + + T D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + +P F GS +D+ + D G GE+ D ++Q L S R + K +S +S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGD--FLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEAS 426
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q6H1V1|BEST3_MOUSE (Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=2 SV=1) HSP 1 Score: 288.115 bits (736), Expect = 1.928e-87 Identity = 156/439 (35.54%), Postives = 236/439 (53.76%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVN-VETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVD-----SNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNS---NRSQKSMF 1400
MTV Y +V +A F +LL KW+G ++KL+Y +FIVF+ LYT IS +YRL+L KR FEK+ Y + IPV F+LGFYV+LV NR+W F +PW ++ ++I+S S+ + RL RR+++RY+ + ++ VS V +RFP +D + G + E ++ + + ++ ++P W + KA +GRI + L + + E+N++R LF D V +PLVYTQVVTLAVY++F +CLIGRQF+ + V D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + + P + KD ++D P D F+GS M + + DW+ + + +R K ++ + E R S S SMF
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISS--------------SVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTIQMGLSGSNFPAEDWLWNYEKHG-NRHSVMRRVKRFLSTHEHPGSPRRRRSFGRQASDSSMF 424
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8N1M1|BEST3_HUMAN (Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1 SV=1) HSP 1 Score: 287.73 bits (735), Expect = 2.993e-87 Identity = 145/386 (37.56%), Postives = 217/386 (56.22%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MTV Y +V +A F +LL KW+G ++KL+Y +FIVF+ LYT IS +YRL+L KR FEK+ Y + IPV F+LGFYV+LV NR+W F +PW ++ +I+S S+ E RL RR+++RY+ + ++ VS V +RFP +D + G + E ++ + + ++ ++P W + KA +GRI + L + + E+N++R LF D V +PLVYTQVVTLAVY++F +CLIGRQF+ + D +PIFT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + + P + KD ++D P D F+GS M + +D
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISS--------------SVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTVQMGLSGSD 372
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|O88870|BEST1_MOUSE (Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=2 SV=3) HSP 1 Score: 276.174 bits (705), Expect = 4.390e-84 Identity = 140/386 (36.27%), Postives = 225/386 (58.29%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MT+ Y +V +A +F LL W+G ++KL+Y +F+VF LY I +YR++L + + FEK+ Y LIP++F+LGFYV+LV +R+W + +PW ++ I ++S + G DE E RL RR++IRY ++ L +S V +RFP + + G + E + ++ ++P W A + MKA GRI + +L + + E+ R +L+ D + +PLVYTQVVT+AVYS+FL+CLIGRQF+ + + + D VVP+FTILQF+ YMGWLK+A L+NP GEDD+DF+ N ++D N ++ L DG+ + PP+ +D ++++ + P + +R FMGS +++ + D
Sbjct: 1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVE-------GKDE-------EGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPPMERDMYWNEAAPQPPYTAASARSRRHSFMGSTFNISLKKED 372
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8BGM5|BEST2_MOUSE (Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=2 SV=1) HSP 1 Score: 272.707 bits (696), Expect = 2.789e-83 Identity = 155/442 (35.07%), Postives = 235/442 (53.17%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNV-ETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSS 1430
MTV Y V +A F +LL W+G ++KL++ + + F LY +S YR +L +E KR FEK+V Y Q SLIPV+F+LGFYV+LV +R+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W +++ +A +GRI + + L ++E+N FR LF D + +PLVYTQVVT+AVYSYFL+CLIGRQF+ + + T D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + +P F GS +D+ + D G GE+ D ++Q L S R + K +S +S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGD--FLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEAS 426
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU1|BEST2_HUMAN (Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1 SV=1) HSP 1 Score: 266.159 bits (679), Expect = 1.058e-80 Identity = 156/464 (33.62%), Postives = 236/464 (50.86%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELP-MESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTIS 1496
MTV Y V +A F +LL W+G ++KL++ + + F Y +S YR +L + KR FEK+V Y Q SLIPV+F+LGFYV+LV NR+W + +P + ++A ++ + RL RR+++RY S ++ L VS V +RFP ID + G + E + +N + ++P W + + +A +GRI + + L ++E+N FR LF D + VPLVYTQVVT+A+YSYFL+CLIGRQF+ + + D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D L KD ++D P + + R F GS +D+ + D G GE D L + L G+ + S +K + + + S A + E P S
Sbjct: 1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAG--------------TVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQPSFQGSTFDITLAKEDMQFQRLDGLDGPMGEAPGDFLQ-RLLPAGAGMVAGGPLGRRLSFLLRKNSCVSEASTGASCSCAVVP--EGAAPECS 447
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A068Y3U9 (Bestrophin homolog OS=Echinococcus multilocularis OX=6211 PE=3 SV=1) HSP 1 Score: 390.578 bits (1002), Expect = 9.999e-127 Identity = 207/475 (43.58%), Postives = 292/475 (61.47%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETT--QDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV------DSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTISKMPEE 1511
MTVQY Q+VL+ GPV FL+LL +WKG V KLIY+DFIVF Y ++SCIYR L ++QFE VV YV+ Q +IP++FILGFYV LVF+RFW+ FN+VPW+ + + + + + AR RR+ +RY+ ASLII SR+ V K+RFP + GIL + E ++I +T+P QPFLP+ W+ I M+A G I N L+N ++ IN FR+ L LFL+D+VCVPLVYTQVVTLAVYSYFLS +IGRQFI+++ + +D+ VP++TIL+FIVYMGWLK+A TLVNPMGEDDEDFD+N ++D N+ G+ + D K L++DKF+D LP ++ K ++ +GSV+++ V D N S ++ G E E +D L+ +SL R S+ S + + ST I + S EA+ P ++++ E+
Sbjct: 1 MTVQYNQDVLTGGPVVFLRLLLRWKGCVIKLIYIDFIVFILAYAVVSCIYRFALTASQQKQFESVVLYVFDFQQMIPISFILGFYVQLVFSRFWQQFNSVPWVFTPTLAVIGAI---------------QGEGRARAIRRTCVRYMNASLIIASSRLHVAAKKRFPTTQHLVQAGILTQREGDLIDSTDPVAAQPFLPLVWATAISMRAEKDGYIRNPHALVNLIQVINGFRESLLRLFLMDKVCVPLVYTQVVTLAVYSYFLSSIIGRQFIVNTSDYSEPFRKDYYVPLYTILEFIVYMGWLKVAETLVNPMGEDDEDFDINAIIDCNWSYGMHMVDR-KYHPTELVRDKFWDSTNVSLPHTADSKKLQSTQMIGSVFNIDVLGTDPHDRNLNTVSAVNLHTGFESEDHHDVLH-ESLG-----PRFKSSDSLEMHNLSGDSPSTPCSIQSTMISPSTNAGEAVLPALAEVDED 453
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A5K3EZP5 (Bestrophin homolog OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 388.267 bits (996), Expect = 6.358e-126 Identity = 189/388 (48.71%), Postives = 257/388 (66.24%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETT--QDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPP-LIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSND 1265
MTVQY Q+VL+ GPV FL+LL +WKG V KLIY+DFIVF Y ++SC+YR L E ++ FE VV YV+ Q +IP++FILGFYV LVF+RFW+HFN+VPW+ + + + + + AR RR+ +RY+ ASLII SR+ V K+RFP + GIL + E ++I +T+P + QPFLP+ W+ I M+A G I N L+N ++ +N FR+ L LFL+D+VCVPLVYTQVVTLAVYSYFLS +IGRQFI+DS + +D+ VP +TIL+FIVYMGWLK+A TLVNPMGEDDEDFD+N ++D N+ G+ + D K P L++DKF+D LP + K + GS+Y++ V + D
Sbjct: 1 MTVQYNQDVLTGGPVVFLRLLLRWKGCVVKLIYVDFIVFMLAYAIVSCVYRFALTAEQQKNFESVVLYVFDFQQMIPISFILGFYVQLVFSRFWQHFNSVPWVFTPTLAVIGAI---------------QGEGRARTIRRTCVRYMNASLIIASSRLHVAAKKRFPTTQHLVQAGILTQREGDLIDSTDPVSAQPFLPLVWTTAIAMRAEKDGLIQNPHALVNLIQVVNNFRESLLRLFLMDKVCVPLVYTQVVTLAVYSYFLSSIIGRQFILDSSEYSSPFRKDYYVPFYTILEFIVYMGWLKVAETLVNPMGEDDEDFDINNIIDSNWSYGMHMVD--KKHHPTELVRDKFWDSSNVILPHTAGSKKLLSTQMTGSMYNLDVATLD 371
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A068WMI5 (Bestrophin homolog OS=Echinococcus granulosus OX=6210 GN=EgrG_000672700 PE=3 SV=1) HSP 1 Score: 387.882 bits (995), Expect = 1.200e-125 Identity = 210/476 (44.12%), Postives = 293/476 (61.55%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETT--QDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV------DSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGI-SMFTSTASLKGLEAITPTISKMPEE 1511
MTVQY Q+VL+ GPV FL+LL +WKG V KLIY+DFIVF Y ++SCIYR L ++QFE VV YV+ Q +IP++FILGFYV LVF+RFW+ FN+VPW+ + + + + + AR RR+ +RY+ ASLII SR+ V K+RFP + GIL + E ++I +T P QPFLP+ W+ I M+A G I N L+N ++ IN FR+ L LFL+D+VCVPLVYTQVVTLAVYSYFLS +IGRQFI+++ + +D+ VP++TIL+FIVYMGWLK+A TLVNPMGEDDEDFD+N ++D N+ G+ + D K L++DKF+D LP ++ K ++ +GSV+++ V D N + ++ G E E ND L +SL R S+ S + + ST I S S A+ G EA+ P ++++ E+
Sbjct: 1 MTVQYNQDVLTGGPVVFLRLLLRWKGCVIKLIYIDFIVFILAYAVVSCIYRFALTASQQKQFESVVLYVFDFQQMIPISFILGFYVQLVFSRFWQQFNSVPWVFTPTLAVIGAI---------------QGEGRARAIRRTCVRYMNASLIIASSRLHVAAKKRFPTTQHLVQAGILTQREGDLIDSTNPVAAQPFLPLVWATAISMRAEKDGYIRNSHALVNLIQVINGFRESLLRLFLMDKVCVPLVYTQVVTLAVYSYFLSSIIGRQFIVNTSDYSEPFRKDYYVPLYTILEFIVYMGWLKVAETLVNPMGEDDEDFDINAIIDCNWSYGMHMVDR-KYHPTELVRDKFWDSTNVSLPHTADSKKLQSTQMIGSVFNIDVLGTDPHDRNLNTVNAVNLHTGLESEDHNDVLR-ESLG-----PRFKSSESLEMHNLPGDSPSTPCSIQSTMISPATNPG-EAVLPALAEVDED 453
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A0R3UIX4 (Bestrophin homolog OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS7414 PE=3 SV=1) HSP 1 Score: 383.259 bits (983), Expect = 1.758e-125 Identity = 187/383 (48.83%), Postives = 255/383 (66.58%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVET--TQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPP-LIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMK 1250
MTVQY Q+VL+ GPV FL+LL +WKG V KLIY+DFIVF Y ++SC+YR L E ++ FE VV YV+ Q +IP++FILGFYV LVF+RFW+HFN+VPW+ + + + + + AR RR+ +RY+ ASLII SR+ V K+RFP + GIL + E ++I +T+P + QPFLP+ W+ I M+A G I N L+N ++ +N FR+ L LFL+D+VCVPLVYTQVVTLAVYSYFLS +IGRQFI+DS + +D+ VP +TIL+FIVYMGWLK+A TLVNPMGEDDEDFD+N ++D N+ G+ + D K P L++DKF+D LP + K + GS+Y+++
Sbjct: 1 MTVQYNQDVLTGGPVVFLRLLLRWKGCVVKLIYVDFIVFMLAYAIVSCVYRFALTAEQQKNFESVVLYVFDFQQMIPISFILGFYVQLVFSRFWQHFNSVPWVFTPTLAVIGAI---------------QGEGRARTIRRTCVRYMNASLIIASSRLHVAAKKRFPTTQHLVQAGILTQREGDLIDSTDPVSAQPFLPLVWTTAIAMRAEKDGLIQNPHALVNLIQVVNNFRESLLRLFLMDKVCVPLVYTQVVTLAVYSYFLSSIIGRQFILDSSEYSSPFRKDYYVPFYTILEFIVYMGWLKVAETLVNPMGEDDEDFDINNIIDSNWSYGMHMVD--KKHHPTELVRDKFWDSSNVILPHTAGSKKLLSTQMTGSMYNLE 366
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A504YTL7 (Bestrophin homolog OS=Fasciola gigantica OX=46835 GN=FGIG_08961 PE=3 SV=1) HSP 1 Score: 375.941 bits (964), Expect = 3.786e-120 Identity = 186/411 (45.26%), Postives = 268/411 (65.21%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ---DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSN-DWITSLKSIAIGSEGE-LRNDKL 1328
MTVQY Q VL+ GP F +LL KW+G VFKLIY D +VF +LY +ISCIYR L E +R FE+++ + Q++IPVAFILGFY++L+FNRFW F +PW+ K AI + +++ SG D + RL RR+ +RY+ SLI+T +R+SV K+RFP ++ + G+ + E ++I +P +Q F+PI W+ +++ A + R+TN+ L+ + E+N FRQ L +LF +D VCVPLVYTQVVTL+VYSYF++ L+GRQ+IM+S Q D P FT+L+FI+YMGWLK+A TLVNPMGEDDEDFD+N V+D+N++ I DG+K P +++D + + V ELP + ++P GSVYD+ V S D+ S S+ G + +R +L
Sbjct: 1 MTVQYNQLVLTGGPGVFFRLLLKWRGCVFKLIYFDILVFGTLYAIISCIYRFALSSEMQRSFERLILFTNNFQAMIPVAFILGFYINLIFNRFWYQFGIIPWVLKFAIALVTNV-------SGFD-------DRTRLIRRTCVRYVLGSLILTTARISVAAKKRFPTMESFVSGGVFTDEEIKMIMAQQPH-VQSFVPIVWATSLITLAEKERRLTNQHALVLLIDELNNFRQGLLKLFFMDYVCVPLVYTQVVTLSVYSYFIASLLGRQYIMESSPFSKEQNLRDLYFPFFTMLEFIIYMGWLKVAETLVNPMGEDDEDFDINEVIDFNWKTAWCIVDGMKPSPPAVVRDIHWHQSVVELPHTEESRRLLSRPCRGSVYDLNVQSTADYFGSGVSLHGGRRSQDVRGRRL 396
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999]) HSP 1 Score: 285.804 bits (730), Expect = 5.543e-87 Identity = 144/383 (37.60%), Postives = 226/383 (59.01%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLI-KDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV 1253
MTV Y + V A F LL +WKG ++KL+Y + ++F+ LY IS +YR +L +E +R FEK+ Y Q LIPV+F+LGFYV+LV +R+W F +VPW ++A ++ ++ +R E ARL RRS++RY S ++ +S V +RFP I+ + G++ E + + + ++P W + ++A T+GRI N+ L + E+N R +L+ D + +PLVYTQVVT+AVYS+FL+CLIGRQF+ + DF +P+FT+LQF Y+GWLK+A L+NP GEDD+DF+ N +VD N ++ L D + D PL+ +DK++++ + P + + + +MGS D+ V
Sbjct: 1 MTVTYSRRVADARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAY--------------VRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEM-YDLVPLVERDKYWNESEPQPPYTAASAEHKKPSYMGSALDISV 368
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127]) HSP 1 Score: 270.781 bits (691), Expect = 5.949e-82 Identity = 145/383 (37.86%), Postives = 215/383 (56.14%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKV 1253
MTV Y V +A F KLL W+G ++K++Y + + F LYT IS YR L DE KR FEK+ Y SLIP++F+LGFYV+L+ NR+W + ++P I +++ + GD E RL RR+++RY + + ++ L VS V +RFP +D + G + E + ++ + ++P W + A ++GRI ++ ++E+NKFR LF D + VPLVYTQVVTLAVYS+FL CLIGRQF+ S D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D P + +D++++ P + KP F GS +DM +
Sbjct: 1 MTVTYTARVANARFCGFSKLLLAWRGSIYKVLYKEVLAFFILYTAISITYRFFLLDEQKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQ------GGD--------ERGRLLRRTLMRYASLASLLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQAYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMFGDLPMMERDRYWNDSNPRPPYTAATLFVLRKPSFQGSTFDMAI 369
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6]) HSP 1 Score: 256.529 bits (654), Expect = 9.065e-80 Identity = 142/385 (36.88%), Postives = 218/385 (56.62%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQ-VVTLAVYSYFLSCLIGRQFI----MDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDM 1247
MTV Y EV +A F KLL +WKG ++KL+Y +F++F LY++ S IYR +L D + FE+ + + LIP++F+L FYV+ F R+W + + P + ++++ +++ G DE RL RR+++RY S ++ L +S V +RFP + I + + E E + + + ++P+TW A + KA +GR+ ++ L + E+N +R LF D + +PLVYTQ VVTLAVYS+F CLIGRQF+ D + V D VP+FT+L+F Y GWLK+ ++NP GEDD+DF+ N ++D N ++ + D + + PPL KDK++ K F P AKP FMGS YDM
Sbjct: 1 MTVSYTLEVANARFAGFTKLLFRWKGSIYKLLYKEFLLFCFLYSLFSLIYRCVLTDGQQELFERAARHCNKFAKLIPMSFVL-FYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVH-------GSDE-------RGRLLRRTLMRYANLSSVLILRSISTRVHKRFPTLQHIVD-AFMTEEEMRTLDHLYSDFNKYWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFVKPERADELKVHV--DLYVPVFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLPPLEKDKYWTDKSFSRPFSP------AKPIFMGSTYDM 361
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999]) HSP 1 Score: 248.44 bits (633), Expect = 2.737e-73 Identity = 133/383 (34.73%), Postives = 210/383 (54.83%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLI-KDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV 1253
MTV Y + V A F LL +WKG ++KL+Y + ++F+ LY IS +YR +L +E +R FEK+ Y Q LIPV+F+LGFYV+LV +R+W F +VPW ++A ++ ++ +R E ARL RRS++RY S ++ +S V +RFP I+ + G++ E + + + ++P W + ++A T+GRI N+ L + VVT+AVYS+FL+CLIGRQF+ + DF +P+FT+LQF Y+GWLK+A L+NP GEDD+DF+ N +VD N ++ L D + D PL+ +DK++++ + P + + + +MGS D+ V
Sbjct: 1 MTVTYSRRVADARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAY--------------VRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILN--------------------------VVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEM-YDLVPLVERDKYWNESEPQPPYTAASAEHKKPSYMGSALDISV 342
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105]) HSP 1 Score: 153.295 bits (386), Expect = 2.977e-40 Identity = 81/227 (35.68%), Postives = 122/227 (53.74%), Query Frame = 3
Query: 576 RVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV 1253
++S+ R I F G + E +I +N + ++ ++P W + KA GRI + L + E+N+FR LF D V +PLVYTQVVTLAVY++F + +IGRQF+ + D VP+FT+LQF Y GWLK+A L+NP GEDD+DF+ N +D N ++ L D + ++ P + KD +++ P D F+GS DM +
Sbjct: 64 KLSIYCDRYAEQIPVTFVLGFMTPEEKKIFENLKSPHLKYWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFLDPAQGYPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWCIDRNLQVSLMAVDEMHMNIPRMTKDVYWNDPDVRPPYTRAAADYCIPSFLGSTTDMGL 290 HSP 2 Score: 78.1814 bits (191), Expect = 5.474e-15 Identity = 35/84 (41.67%), Postives = 55/84 (65.48%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGF 362
MTV Y +V +A F +LL +W+G ++KL+Y +F+ F+ LY+++S +YR +L D +R FEK+ Y + IPV F+LGF
Sbjct: 1 MTVTYSSKVANATFFGFHRLLLRWRGSIYKLLYREFLFFALLYSILSLVYRWVLTDPQRRLFEKLSIYCDRYAEQIPVTFVLGF 84
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214]) HSP 1 Score: 270.396 bits (690), Expect = 9.117e-86 Identity = 140/380 (36.84%), Postives = 212/380 (55.79%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMK 1250
MTV Y +V +A F +LL +WKG ++KL+Y +F +F L+ +S +YR +L++ KR FEK+ Y + LIPV+F+LGFYV+LV +R+W + ++PW ++ ++A +++ G D E RL RR+++RY S ++ L VS V +RFP +D + G + E + ++P W A + +A +GRI + L + ++N FR L+ D V +PLVYTQVVT+AVYS+FL+CLIGRQF+ D +P+FT+LQF Y GWLK+A L+NP GEDD+DF+ N VD N ++ L D + D PPL D ++D P F GS +D++
Sbjct: 1 MTVTYSNKVANARLGGFSQLLLRWKGSIYKLLYKEFCIFLVLFFTLSSVYRYMLQENQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDRLMHLVACNVH-------GAD-------ERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTPAERRKFDGLRSPHNKFWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQFLGPQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEANWCVDRNLQVSLMGVDEMYRDLPPLEHDVYWDDISPCPPYTGASLVHHKASFQGSTFDVR 366
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127]) HSP 1 Score: 252.677 bits (644), Expect = 3.314e-77 Identity = 132/387 (34.11%), Postives = 211/387 (54.52%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKVDSND 1265
MTV Y V +A F KLL +W+G ++KL+Y +F ++ +Y +S R L ++ KR FEK+ Y +LIPV GFYV+LV +R+W + ++P ++ +A ++ V E RL RR+++RY S ++ L VS V +RFP +D + G + E + + ++P W +++ +A +GR+ ++ L + E+N +R LF D + VPLVYTQVVT+AVYS+FL+CLIGRQF+ + D +P+FT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D N ++ + D + + P L +D +++ P + KP F+GS +DM + +D
Sbjct: 1 MTVTYTNRVANARLCGFSKLLLQWRGSIYKLLYREFSIYFMMYAALSLTSRFALSEDQKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIPTPDRLMCAVAGTVHGV--------------DERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTRDERKRFDGLRCSYNKYWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPAQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNLQVSMLAVDEMYQNLPLLQRDMYWNASDPRPPYTAATMSTLHKPSFLGSAFDMSMHKDD 373
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121]) HSP 1 Score: 286.574 bits (732), Expect = 5.680e-88 Identity = 143/383 (37.34%), Postives = 222/383 (57.96%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ--DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKV 1253
MTV Y +V +A ++F +LL +W+G ++KL+Y +F++F+ LYT++S IYRL L ++ KR FEK+ Y + IPV F+LGFYV+LV NR+W F +PW ++ I+S ++ E RL RR+++RY+ + ++ VS V +RFP ID + G + E ++ +N ++ ++P+ W + + +A +GRI + L N + E+N FR LF D V +PLVYTQVVTLAVY++F +C+IGRQF +D D VP+FT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D N ++ L D + ++ P + KD +++ P D F+GS DM +
Sbjct: 1 MTVTYSSKVANATFLSFHRLLLRWRGSIYKLLYREFLLFALLYTILSLIYRLALSEQQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISS--------------CVQGKDEYGRLLRRTLVRYINLTSLLIFRSVSTAVCKRFPTIDHVVEAGFMTPEERKVFENIRSPHLKYWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQF-LDPAQGHPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWIIDRNLQVSLLAVDEMHMNLPHMTKDIYWNDSDARPPYTLAAADYCIPSFLGSTTDMGL 368
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962]) HSP 1 Score: 277.715 bits (709), Expect = 4.279e-85 Identity = 147/383 (38.38%), Postives = 216/383 (56.40%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKP-FMGSVYDMKV 1253
MTV Y V +A F KLL WKG ++K++Y +F+ F LY IS YR L ++ KR FEK+ Y SLIP++F+LGFYV+L+ NR+W + ++P +I +++ + G+DE RL RRS++RY + S ++ L VS V +RFP +D + G + E + + + ++P W + A +GRI ++ L ++E+N FR LF D V VPLVYTQVVTLAVYS+FL CLIGRQF+ S + D VPIFT+LQF Y GWLK+A L+NP GEDD+DF+ N ++D NF++ + D + D P + +D++++ P + KP F GS +DM +
Sbjct: 1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFVLYAAISITYRFFLYEDQKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQ-------GNDE-------RGRLLRRSMMRYASLSALLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFEGLHSPYNKYWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQGYQGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPVMERDRYWNDSNPRPPYTAATLFGLRKPSFQGSTFDMAI 369
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866]) HSP 1 Score: 264.618 bits (675), Expect = 4.482e-79 Identity = 139/383 (36.29%), Postives = 216/383 (56.40%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGIL---LEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDM 1247
MTV Y + V AG F LL +WKG ++KL+Y + I+F+ LY +S +Y +L ++ +R FE++ Y + LIPV+F+L FYV+LV +R+W F +PW ++A ++ H +R E +RL RR+++RY+ S ++ VS V +RFP + + + L H E+ F ++P W + ++A T+GRI N+ L + E+N R +L+ D + +PLVYTQV T+AVYS+FL+CLIGRQF+ + DF +P+FT+LQF Y+GWLK+A L+NP GEDD+DF+ N VVD N ++ L D + P + KD +++ + P + + R FMGS D+
Sbjct: 1 MTVTYSRRVADAGLGTFFHLLLRWKGSIYKLLYRELIIFTLLYYFLSLVY-YMLDNDQRRLFERLSIYCDRYAELIPVSFVL-FYVTLVVSRWWGQFENIPWPDRLAALVGGH--------------VRGTDEASRLTRRALMRYVNLSGVLIYRSVSTAVYKRFPTTEHLVQALMTSEELRHFEELPSPHNKF----WVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFLDPAQGYPGHDVDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWVVDRNLQVSLLSVDEMYDSLPLVEKDVYWNDSEPQPPYTAASAEHRKPSFMGSALDI 363
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000030918.1 (SMESG000030918.1) HSP 1 Score: 1057.36 bits (2733), Expect = 0.000e+0 Identity = 530/533 (99.44%), Postives = 531/533 (99.62%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTISKMPEEIDEPPTPVKSNEKHPLLVXXXXXXXXXXXXXLKSIRKSRDYLNENSADENDESSLKESLCSGQSKV 1709
MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTISKMPEEIDEPPTPVKSNEKHPLLVIEEEEQSQGNEIELK IRKSRD LNENSADENDE+SLKESLCSGQSKV
Sbjct: 1 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSEGELRNDKLYIQSLEDKKGVSRNNSNRSQKSMFTKKRTISTSSGISMFTSTASLKGLEAITPTISKMPEEIDEPPTPVKSNEKHPLLVIEEEEQSQGNEIELKPIRKSRDDLNENSADENDENSLKESLCSGQSKV 533
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000030927.1 (SMESG000030927.1) HSP 1 Score: 487.263 bits (1253), Expect = 3.092e-168 Identity = 230/398 (57.79%), Postives = 313/398 (78.64%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSE 1304
MTV+YYQ+VL+AGP+ FLKLL +WKG +F+LIY D ++F++ Y IS I+R +L +++KRQFE V++YV +SQ+LIPVAFI+GFYV+L+F+RFW+HFNT+PWI+K A+++++ ++ I+K+KE+ RLQ+R+IIRYL +SL+ITLSRVS+PVKRRF NI+E+ NKGILLEHE+ +I+ EP+ MQPFLP+ I NE++LI V+EINKFRQLLQELFLLDQ+CVPLVYTQVVTLA+YSYFLSCL+GRQFI+ S ++ DFV+PIFTILQFIVY+GW+KLAL+LVNPMGEDDEDFDLN ++DYNF+ G++ + +K QPP KD FF+ K+++LP+ K + +PF GS +M++D+ +WI S+KS+ I E
Sbjct: 1 MTVKYYQDVLTAGPIGFLKLLIRWKGSIFRLIYSDLLLFAAFYMAISMIHRFMLPEDNKRQFETVINYVAKSQALIPVAFIVGFYVNLIFSRFWQHFNTIPWISKTALLVSTFFQDPEFNPEMSEDEIKKEKEKTRLQKRTIIRYLVSSLLITLSRVSIPVKRRFKNINELSNKGILLEHESGLIEKCEPYIMQPFLPVI--------------IPNESLLIGIVEEINKFRQLLQELFLLDQICVPLVYTQVVTLAIYSYFLSCLVGRQFIIVSDYLKNRNDFVIPIFTILQFIVYIGWIKLALSLVNPMGEDDEDFDLNTLIDYNFQTGISSVENLKSSQPPFEKDFFFNSKIYKLPLNEKSKFNKTRPFRGSFCEMRIDNENWIASIKSLLIDKE 384
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000030927.1 (SMESG000030927.1) HSP 1 Score: 446.432 bits (1147), Expect = 1.221e-152 Identity = 216/398 (54.27%), Postives = 292/398 (73.37%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVDSNDWITSLKSIAIGSE 1304
MTV+YYQ+VL+AGP+ FLKLL +WKG +F+LIY D ++F++ Y IS I+R +L +++KRQFE V++YV +SQ+LIPVAFI+GFYV+L+F+RFW+HFNT+PWI+K A+++++ ++ I+K+KE+ RLQ+R+IIRYL +SL+ITLSRVS+PVKRRF NI+E+ NKGILLEHE+E EINKFRQLLQELFLLDQ+CVPLVYTQVVTLA+YSYFLSCL+GRQFI+ S ++ DFV+PIFTILQFIVY+GW+KLAL+LVNPMGEDDEDFDLN ++DYNF+ G++ + +K QPP KD FF+ K+++LP+ K + +PF GS +M++D+ +WI S+KS+ I E
Sbjct: 1 MTVKYYQDVLTAGPIGFLKLLIRWKGSIFRLIYSDLLLFAAFYMAISMIHRFMLPEDNKRQFETVINYVAKSQALIPVAFIVGFYVNLIFSRFWQHFNTIPWISKTALLVSTFFQDPEFNPEMSEDEIKKEKEKTRLQKRTIIRYLVSSLLITLSRVSIPVKRRFKNINELSNKGILLEHESE-------------------------------------------EINKFRQLLQELFLLDQICVPLVYTQVVTLAIYSYFLSCLVGRQFIIVSDYLKNRNDFVIPIFTILQFIVYIGWIKLALSLVNPMGEDDEDFDLNTLIDYNFQTGISSVENLKSSQPPFEKDFFFNSKIYKLPLNEKSKFNKTRPFRGSFCEMRIDNENWIASIKSLLIDKE 355
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000054993.1 (SMESG000054993.1) HSP 1 Score: 235.728 bits (600), Expect = 1.681e-71 Identity = 129/383 (33.68%), Postives = 224/383 (58.49%), Query Frame = 3
Query: 111 MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFI-MDSVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSVYDMKVD 1256
MT+ Y V ++ FL+LL +WKG ++K+I+ + IVF++LYT +SC+YR L +K++FE+ ++ ++ +IPV F+LGFYV+LV +R+W F +PW +AI +++ + DD+S+ + RR+I+RYL S +T + +S KR FP++ + G+L + E +I+ E + F+P W++ +V +A ++ E + ++EI KFR L ++ D + PLVYTQ+ T++V++YF+ + QFI D V+V VP+F LQF+ YMGWLK+A +L+NP G+DD+DF+++ ++ N ++ I D + P L KD F++ ++ + + K + F GS+ ++ D
Sbjct: 1 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFI------LGNDDKSV--------MYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDV------YVPMFGFLQFVFYMGWLKVAESLINPFGDDDDDFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNR-DIQIIHDYKSPKNDMFAGSLLNLNTD 362
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000040095.1 (SMESG000040095.1) HSP 1 Score: 216.468 bits (550), Expect = 6.283e-65 Identity = 120/347 (34.58%), Postives = 191/347 (55.04%), Query Frame = 3
Query: 201 LIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMDSVNVETTQ-DFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQPPLIKDKFFDKKVFELPMESNMKDARAKPFMGSV 1238
+++ + ++F LY+ IS +YR +L +K QFE+ Y + +P+AFIL FYV+++ NR+W FN +PW +A+ + NT P NS + + +R+++RYL SL++ L VS K+RFP + + + E E + +P + ++PI W++ ++ KA G I E L N + EI++FR+ L +LF D V PLVYTQ T+AVY+YF++ L RQF+ + DF VP+F ++Q + Y GWLK+A L+NP GEDD+DFD +++ N + P L+KD F+D E P++ N F+GS+
Sbjct: 1 MVWFELVLFGILYSSISIMYRNLLSGLYKEQFERFCIYCDSIGNFMPIAFILSFYVTMIANRWWEQFNIIPWPDHVALFV----NTYIPGNS----------VKLVMLKRNVVRYLNISLLLYLRSVSPQTKKRFPTEASLMDARLFNETEFNLFNQIDPTYNRYYVPIIWASNLIKKAFIDGDIKTEGRLNNIILEISQFRERLIKLFSYDWVNPPLVYTQTATIAVYTYFVTSLFSRQFLDPNKGYRNHNIDFYVPVFFLIQLVFYFGWLKVAECLINPFGEDDDDFDCLGLIERNITANFIFVKPLIEPHPVLMKDVFWDV---ESPIKLNNYKDDVNFFVGSM 330 The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004353 ID=SMED30004353|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1778bpback to top protein sequence of SMED30004353-orf-1 >SMED30004353-orf-1 ID=SMED30004353-orf-1|Name=SMED30004353-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=534bp MTVQYYQEVLSAGPVAFLKLLRKWKGGVFKLIYMDFIVFSSLYTMISCIYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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