Proliferating cell nuclear antigen

Overview


Name	Proliferating cell nuclear antigen
Smed ID	SMED30004304
Length (bp)	907

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Proliferating cell nuclear antigen (SMED30004304) t-SNE clustered cells

Violin plots show distribution of expression levels for Proliferating cell nuclear antigen (SMED30004304) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Proliferating cell nuclear antigen (SMED30004304) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Proliferating cell nuclear antigen (SMED30004304) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Expression Details

Proliferating cell nuclear antigen ( PCNA ) is expressed during Stage 2, Stage 3, Stage 4, Stage 5, Stage 6, Stage 7 and Stage 8 in the neoblast and blastomere

Click to see image symbols and abbreviations


Abbreviation or symbol	Definition
O	oral hemisphere
A	aboral hemisphere
D	dorsal
V	ventral
L	lateral
black arrowhead	embryonic pharynx
red arrowhead	definitive pharynx
black arrows	primitive gut
yellow arrows	primitive ectoderm cells
cyan arrows	brain
cyan arrowheads	nerve cords
blue arrowheads	eye progenitors (trail cells)
purple arrowheads	eyes
scale bar	100 µm

**Cell cycle activity is restricted to piwi-1 blastomeres, and all blastomeres are cycling.**
SPIM reconstructed S4 embryo costained with piwi-1 (red) and PCNA (green). PCNA expression is restricted to piwi-1+ blastomeres, and all piwi-1+ cells co-express PCNA.

**Cell cycle activity is restricted to piwi-1 blastomeres, and all blastomeres are cycling.**
SPIM reconstructed S3 embryo costained with piwi-1 (red) and PCNA (green). PCNA expression is restricted to piwi-1+ blastomeres, and all piwi-1+ cells co-express PCNA.

**Cell cycle activity is restricted to piwi-1 blastomeres, and all blastomeres are cycling.**
SPIM reconstructed S5 embryo costained with piwi-1 (red) and PCNA (green). PCNA expression is restricted to piwi-1+ blastomeres, and all piwi-1+ cells co-express PCNA.

Anatomical Expression

PAGE et. al., 2020

SMED30004304

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 36

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
X1 cell	SMED30004304	EU856391	smed_ncbi_20200123	PMID:23629965 Zeng et al., 2013
X1 cell	SMED30004304	SmedASXL_002240	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30004304	SmedASXL_002240	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
cephalic ganglia	SMED30004304	dd_Smed_v4_1920_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30004304	dd_Smed_v4_1920_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30004304	DN300872	ncbi_smed_ests	PMID:21566185 Wagner et al., 2011
neoblast	SMED30004304	EU856391	smed_ncbi_20200123	PMID:21566185 Wagner et al., 2011
parapharyngeal region	SMED30004304	dd_Smed_v6_1920_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
neoblast	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
neoblast	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
neoblast	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	SMED30004304	smed_20140614	PMID:28072387 Davies et al., 2017
neoblast	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
neoblast	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
neoblast	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
blastomere	SMED30004304	EU856391	smed_ncbi_20200123	PMID:28072387 Davies et al., 2017
neoblast	SMED30004304	SMED30004304	smed_20140614	PMID:22445864 Tu et al., 2012
X1 cell	SMED30004304	CUFF.66956.1	be_Smed_v2	PMID:22543868 Onal et al., 2012
zeta neoblast	SMED30004304	dd_Smed_v4_1920_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
neoblast	SMED30004304	EU856391	smed_ncbi_20200123	PMID:21747960 Hollenbach et al., 2011
neoblast	SMED30004304	EU856391	smed_ncbi_20200123	PMID:21747960 Hollenbach et al., 2011
X1 cell	SMED30004304	EU856391	smed_ncbi_20200123	PMID:21747960 Hollenbach et al., 2011
neoblast	SMED30004304	SMED_02599_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30004304	SMED_02599_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Human
Match: PCNA (proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729])

HSP 1 Score: 338.961 bits (868), Expect = 4.730e-117
Identity = 151/259 (58.30%), Postives = 211/259 (81.47%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L++G + KKV+EA+KDL+ EA  D S +G++LQ+MD+SHVSLV + LRS+GF+TYRCDRN+ +G+N+TS+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLS IG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLSS V+LS++ +VP V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEE 259

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Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L++G + KKV+EA+KDL+ EA  D S +G++LQ+MD+SHVSLV + LRS+GF+TYRCDRN+ +G+N+TS+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLS IG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLSS V+LS++ +VP V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Celegans
Match: pcn-1 (Proliferating cell nuclear antigen [Source:UniProtKB/Swiss-Prot;Acc:O02115])

HSP 1 Score: 253.447 bits (646), Expect = 6.671e-84
Identity = 115/260 (44.23%), Postives = 178/260 (68.46%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADS-SETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEAKL    + KK++E+IKDLV +A  DCSE  +SLQAMD+SHV+LVS+ L    F+TYRCDR +NLGL++ ++SK LK   ++D+  +K  ++  ++I         ++  +  +K+MD+D +HLGIPD +Y  + +MP+ + Q+ C+DLS   +++ I  TK G+ F   GD+G   +  + +S+ D E E VT+E+ +PV++ +S++Y N FTKA  LS +V LSL  +VP V+E+ IE+ G++R+YLAPKI+DDE
Sbjct:    1 MFEAKLANAGLLKKIVESIKDLVTDAPFDCSETAMSLQAMDSSHVALVSLKLEVGLFDTYRCDRTINLGLSLANMSKALKCANNDDTCMLKYEENEGDSIIFTFADPKRDKTQDVTVKMMDIDSEHLGIPDQDYAVVCEMPAGEFQKTCKDLSTFSDSLNITATKAGIVFTGKGDIGSSVVTYSPSSNTDDETEAVTLEVKDPVNVNFSIKYMNQFTKATALSDRVRLSLCNDVPVVVEYPIEENGYLRFYLAPKIDDDE 260

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Fly
Match: PCNA (gene:FBgn0005655 transcript:FBtr0086308)

HSP 1 Score: 340.887 bits (873), Expect = 3.196e-118
Identity = 149/259 (57.53%), Postives = 210/259 (81.08%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L +  + KK+++AIKDL+ EAT DCS++GI LQAMD SHVSLVS+ LRSDGF+ +RCDRN+++G+N+ S++KILK   + D++TMKA D+++T++++ ESAN+ ++S+YE+KLM+LD +HLGIP+T++ C+V+MP+ +  RICRDL+Q  E++ IC TK+GV F+A+GD+G   IKL Q  S DKE E V IEM EPV++T++ RY N FTKA PLS+QV LS+  +VP V+E+ I+DLG IRYYLAPKIED+E
Sbjct:    1 MFEARLGQATILKKILDAIKDLLNEATFDCSDSGIQLQAMDNSHVSLVSLTLRSDGFDKFRCDRNLSMGMNLGSMAKILKCANNEDNVTMKAQDNADTVTIMFESANQEKVSDYEMKLMNLDQEHLGIPETDFSCVVRMPAMEFARICRDLAQFSESVVICCTKEGVKFSASGDVGTANIKLAQTGSVDKEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSTQVQLSMCADVPLVVEYAIKDLGHIRYYLAPKIEDNE 259

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Fly
Match: PCNA (gene:FBgn0005655 transcript:FBtr0086307)

HSP 1 Score: 340.887 bits (873), Expect = 3.196e-118
Identity = 149/259 (57.53%), Postives = 210/259 (81.08%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L +  + KK+++AIKDL+ EAT DCS++GI LQAMD SHVSLVS+ LRSDGF+ +RCDRN+++G+N+ S++KILK   + D++TMKA D+++T++++ ESAN+ ++S+YE+KLM+LD +HLGIP+T++ C+V+MP+ +  RICRDL+Q  E++ IC TK+GV F+A+GD+G   IKL Q  S DKE E V IEM EPV++T++ RY N FTKA PLS+QV LS+  +VP V+E+ I+DLG IRYYLAPKIED+E
Sbjct:    1 MFEARLGQATILKKILDAIKDLLNEATFDCSDSGIQLQAMDNSHVSLVSLTLRSDGFDKFRCDRNLSMGMNLGSMAKILKCANNEDNVTMKAQDNADTVTIMFESANQEKVSDYEMKLMNLDQEHLGIPETDFSCVVRMPAMEFARICRDLAQFSESVVICCTKEGVKFSASGDVGTANIKLAQTGSVDKEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSTQVQLSMCADVPLVVEYAIKDLGHIRYYLAPKIEDNE 259

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Fly
Match: PCNA2 (gene:FBgn0032813 transcript:FBtr0081262)

HSP 1 Score: 264.233 bits (674), Expect = 4.958e-88
Identity = 121/257 (47.08%), Postives = 182/257 (70.82%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIED 844
            M EA+L +  + KK+++A+K+++ + TLDCSENG+ LQ+MD SHVSLV++ L SD FE + CDRNV+LGL++ S+ K+LK   S+D++T+KA D  E I+L  ES  +   ++YE+KL++LD DH+ IP  +Y C +++PSS+  RICRD+S   E++TI  +  G+ F A GDLG   I+L+  ++ D     V+IE+ EPV+ +++ RY N FTKA PL+ +V L L++  P ++E+ IED G IRYYLAPK+ D
Sbjct:    1 MLEARLSQTLLLKKIVDALKEIIAQGTLDCSENGLELQSMDNSHVSLVALSLASDCFEKFHCDRNVSLGLDLKSLGKVLKCANSDDAVTIKAVDRPEKITLSFESDGKERTADYELKLLNLDQDHMEIPKKDYTCFIQLPSSEFARICRDMSMFDESLTIACSSKGIRFLAKGDLGTANIQLSAGTAMD-----VSIEVQEPVTQSFAGRYLNTFTKATPLADRVKLYLSDERPLLVEYPIEDYGHIRYYLAPKVND 252

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Zebrafish
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:30678])

HSP 1 Score: 328.561 bits (841), Expect = 3.474e-113
Identity = 145/258 (56.20%), Postives = 208/258 (80.62%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L++G + KKV+EA+KDL+ EA  D S +GISLQ+MD+SHVSLV + LRSDGF++YRCDRN+ +G+N++S+SKILK  G+ D +T++A D+++ ++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLSQIG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE+E VTIEM EPV + ++L Y N FTKA PLS  V+LS++ ++P V+E+ I D+G ++YYLAPKI+++
Sbjct:    1 MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRSDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDNADALALVFETLNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVMISCAKDGVKFSASGELGTGNIKLSQTSNVDKEDEAVTIEMNEPVQLIFALNYLNFFTKATPLSKTVTLSMSADIPLVVEYKIADMGHVKYYLAPKIDEE 258

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Xenopus
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:493302])

HSP 1 Score: 335.88 bits (860), Expect = 5.356e-116
Identity = 148/259 (57.14%), Postives = 209/259 (80.69%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L++G + KKV+EA+KDL+ EA  D + +GISLQ+MD+SHVSLV + LRSDGF+TYRCDRN ++G+ ++S+SKILK   S D +T++A D+++T++++ ES N+ ++S+YE+KLMDLD + LGIP+ EY C++KMPS +  RICRDLSQIG+A+ I   KDGV F+A+G+LG G +KL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLS  V+LS++ ++P V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLVQGSILKKVLEALKDLIDEACWDITSSGISLQSMDSSHVSLVQLTLRSDGFDTYRCDRNQSIGVKMSSMSKILKCAASEDIITLRAEDNADTVTMVFESPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSQIGDAVVISCAKDGVKFSASGELGTGNVKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADIPLVVEYKIADMGHVKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Xenopus
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:493302])

HSP 1 Score: 301.212 bits (770), Expect = 2.962e-102
Identity = 133/234 (56.84%), Postives = 188/234 (80.34%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVP 775
            MFEA+L++G + KKV+EA+KDL+ EA  D + +GISLQ+MD+SHVSLV + LRSDGF+TYRCDRN ++G+ ++S+SKILK   S D +T++A D+++T++++ ES N+ ++S+YE+KLMDLD + LGIP+ EY C++KMPS +  RICRDLSQIG+A+ I   KDGV F+A+G+LG G +KL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLS  V+LS++ ++P
Sbjct:    1 MFEARLVQGSILKKVLEALKDLIDEACWDITSSGISLQSMDSSHVSLVQLTLRSDGFDTYRCDRNQSIGVKMSSMSKILKCAASEDIITLRAEDNADTVTMVFESPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSQIGDAVVISCAKDGVKFSASGELGTGNVKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADIP 234

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Mouse
Match: Pcna (proliferating cell nuclear antigen [Source:MGI Symbol;Acc:MGI:97503])

HSP 1 Score: 335.109 bits (858), Expect = 9.832e-116
Identity = 149/259 (57.53%), Postives = 209/259 (80.69%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+LI+G + KKV+EA+KDL+ EA  D S  G++LQ+MD+SHVSLV + LRS+GF+TYRCDRN+ +G+N+TS+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C++KMPS +  RICRDLS IG+A+ I   K+GV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLS  V+LS++ +VP V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLIQGSILKKVLEALKDLINEACWDVSSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSHIGDAVVISCAKNGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVHLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
Match: sp|P17917|PCNA_DROME (Proliferating cell nuclear antigen OS=Drosophila melanogaster OX=7227 GN=PCNA PE=1 SV=2)

HSP 1 Score: 340.887 bits (873), Expect = 3.204e-117
Identity = 149/259 (57.53%), Postives = 210/259 (81.08%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L +  + KK+++AIKDL+ EAT DCS++GI LQAMD SHVSLVS+ LRSDGF+ +RCDRN+++G+N+ S++KILK   + D++TMKA D+++T++++ ESAN+ ++S+YE+KLM+LD +HLGIP+T++ C+V+MP+ +  RICRDL+Q  E++ IC TK+GV F+A+GD+G   IKL Q  S DKE E V IEM EPV++T++ RY N FTKA PLS+QV LS+  +VP V+E+ I+DLG IRYYLAPKIED+E
Sbjct:    1 MFEARLGQATILKKILDAIKDLLNEATFDCSDSGIQLQAMDNSHVSLVSLTLRSDGFDKFRCDRNLSMGMNLGSMAKILKCANNEDNVTMKAQDNADTVTIMFESANQEKVSDYEMKLMNLDQEHLGIPETDFSCVVRMPAMEFARICRDLAQFSESVVICCTKEGVKFSASGDVGTANIKLAQTGSVDKEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSTQVQLSMCADVPLVVEYAIKDLGHIRYYLAPKIEDNE 259

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BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
Match: sp|P61258|PCNA_MACFA (Proliferating cell nuclear antigen OS=Macaca fascicularis OX=9541 GN=PCNA PE=2 SV=1)

HSP 1 Score: 338.961 bits (868), Expect = 2.271e-116
Identity = 151/259 (58.30%), Postives = 211/259 (81.47%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L++G + KKV+EA+KDL+ EA  D S +G++LQ+MD+SHVSLV + LRS+GF+TYRCDRN+ +G+N+TS+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLS IG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLSS V+LS++ +VP V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
Match: sp|P12004|PCNA_HUMAN (Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1)

HSP 1 Score: 338.961 bits (868), Expect = 2.271e-116
Identity = 151/259 (58.30%), Postives = 211/259 (81.47%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L++G + KKV+EA+KDL+ EA  D S +G++LQ+MD+SHVSLV + LRS+GF+TYRCDRN+ +G+N+TS+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLS IG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLSS V+LS++ +VP V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
Match: sp|O16852|PCNA_SARCR (Proliferating cell nuclear antigen OS=Sarcophaga crassipalpis OX=59312 GN=PCNA PE=3 SV=1)

HSP 1 Score: 338.576 bits (867), Expect = 2.701e-116
Identity = 148/259 (57.14%), Postives = 208/259 (80.31%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+LI   + KK+++AIK+L+ EAT +CSE+GI LQAMD SHVSL S+ LRSDGF+ +RCDRN+++G+N+ S++KILK   ++D++T+KA D+++T++ + ES N  ++S+YE+KLM+LD +HLGIP+T+Y C+V+MPS +  RICRDL+Q  E++ IC TK+GV F+A+GD+G   +KL Q SS DKE E V IEM EPV++T++ RY N FTKA PLS+QV LS+  +VP V+E+ I++LG IRYYLAPKIEDDE
Sbjct:    1 MFEARLINATILKKILDAIKELLHEATFECSESGIQLQAMDNSHVSLGSLTLRSDGFDKFRCDRNISMGMNLGSMAKILKCANNDDTVTVKAQDNADTVTFMFESPNHEKVSDYEMKLMNLDQEHLGIPETDYSCVVRMPSMEFARICRDLAQFSESMLICCTKEGVKFSASGDVGSANVKLAQTSSVDKEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSAQVQLSMCADVPLVVEYAIKELGHIRYYLAPKIEDDE 259

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BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
Match: sp|P57761|PCNA_CRIGR (Proliferating cell nuclear antigen OS=Cricetulus griseus OX=10029 GN=PCNA PE=1 SV=1)

HSP 1 Score: 336.65 bits (862), Expect = 1.410e-115
Identity = 150/259 (57.92%), Postives = 209/259 (80.69%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA+L++G + KKV+EA+KDL+ EA  D S  G++LQ+MD+SHVSLV + LRS+GF+TYRCDRN+ +G+N+TS+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLS IG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV +T++LRY N FTKA PLS  V+LS++ +VP V+E+ I D+G ++YYLAPKIED+E
Sbjct:    1 MFEARLVQGSILKKVLEALKDLINEACWDISSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSTDVPLVVEYKISDMGHLKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. TrEMBL
Match: Q5H7M5 (Proliferating cell nuclear antigen OS=Dugesia japonica OX=6161 GN=Djpcna PE=2 SV=1)

HSP 1 Score: 434.491 bits (1116), Expect = 1.123e-151
Identity = 215/259 (83.01%), Postives = 243/259 (93.82%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEAK+IKGE+ KK IEAIKDL+QEATLDCSENGISLQAMDTSHVSLVS+LLRS+GFETYRCDRN+NLGLN+ SVSKILK LGSNDSLTMKAADS++TIS LIES+NE+ELSE+EIKLMD++GDHLGIPDTEYKCIVKMPS+KLQ+IC+++SQ+GEAITI V KDGVTF + GD+G G   L+QNSSADKENEGVTIEMTEPVSMTYSLRYFNMF KAAPLS  VSLSLTENVPAV+EF+I+D+G+IRYYLAPKIEDDE
Sbjct:    1 MFEAKIIKGEILKKAIEAIKDLIQEATLDCSENGISLQAMDTSHVSLVSLLLRSEGFETYRCDRNINLGLNVVSVSKILKCLGSNDSLTMKAADSNDTISFLIESSNESELSEFEIKLMDIEGDHLGIPDTEYKCIVKMPSAKLQKICKEMSQMGEAITITVAKDGVTFVSTGDIGNGKTTLHQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFAKAAPLSPIVSLSLTENVPAVVEFLIDDIGYIRYYLAPKIEDDE 259

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BLAST of Proliferating cell nuclear antigen vs. TrEMBL
Match: C1L8V7 (Proliferating cell nuclear antigen OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 406.371 bits (1043), Expect = 1.523e-140
Identity = 187/258 (72.48%), Postives = 227/258 (87.98%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L + +VWKKVI+AIKDLVQEATLDC+ENGISLQAMD +HVSLVS+LLRSDGFETYRCDRN++LGLNITS SKIL+    ND++T+KA D ++T++ + ES N+   SE+EIKLMDLD DHLGIPDT+YKCI++MPS++LQRICRDLSQIG+++ I V KDGV+F++ GDLG G +KL+Q+++ADK  E V+IEM E VSMTYSL YFN+FTKAAPLSSQV LSLTENVPAV+EF IEDLG+IRYYLAPKIEDD
Sbjct:    1 MFEARLTQADVWKKVIDAIKDLVQEATLDCTENGISLQAMDNAHVSLVSLLLRSDGFETYRCDRNLSLGLNITSASKILRCASGNDAITLKAGDKADTLTFVFESKNQERSSEFEIKLMDLDVDHLGIPDTDYKCIIRMPSAQLQRICRDLSQIGDSVVISVAKDGVSFSSNGDLGTGNVKLSQSANADKPEESVSIEMHEAVSMTYSLHYFNIFTKAAPLSSQVVLSLTENVPAVVEFGIEDLGYIRYYLAPKIEDD 258

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BLAST of Proliferating cell nuclear antigen vs. TrEMBL
Match: C1L8V9 (Proliferating cell nuclear antigen OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 405.216 bits (1040), Expect = 4.705e-140
Identity = 186/258 (72.09%), Postives = 227/258 (87.98%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L + +VWKKVI+AIKDLVQEATLDC+ENGISLQAMD +HVSLVS+LLRSDGFETYRCDRN++LGLNITS SKIL+    ND++T+KA D ++T++ + ES N+   SE+EIKLMDLD DHLGIPDT+YKCI++MPS++LQRICRDLSQIG+++ I V KDGV+F++ GDLG G +KL+Q+++ADK  E V+IEM E VSMTYSL YFN+FTKAAPLSSQV LSLTENVPAV+EF I+DLG+IRYYLAPKIEDD
Sbjct:    1 MFEARLTQADVWKKVIDAIKDLVQEATLDCTENGISLQAMDNAHVSLVSLLLRSDGFETYRCDRNLSLGLNITSASKILRCASGNDAITLKAGDKADTLTFVFESKNQERSSEFEIKLMDLDVDHLGIPDTDYKCIIRMPSAQLQRICRDLSQIGDSVVISVAKDGVSFSSNGDLGTGNVKLSQSANADKPEESVSIEMHEAVSMTYSLHYFNIFTKAAPLSSQVVLSLTENVPAVVEFGIDDLGYIRYYLAPKIEDD 258

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BLAST of Proliferating cell nuclear antigen vs. TrEMBL
Match: A0A430QDB7 (Proliferating cell nuclear antigen OS=Schistosoma bovis OX=6184 GN=DC041_0004054 PE=3 SV=1)

HSP 1 Score: 404.06 bits (1037), Expect = 1.261e-139
Identity = 186/258 (72.09%), Postives = 227/258 (87.98%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L + +VWKKVI+AIKDLVQEATLDC+ENGISLQAMD +HVSLVS+LLRSDGFETYRCDRN++LGLNITS SKIL+    ND++T+KA D ++T++ + ES +++  SE+EIKLMDLD DHLGIPDT+YKCI++MPS++LQRICRDLSQIG+++ I V KDGV+F++ GDLG G +KL Q+++ADK  E V+IEM EPV MTYSL YFN+FTKAAPLSSQV LSLTENVPAV+EF IEDLG+IRYYLAPKIEDD
Sbjct:    1 MFEARLTQADVWKKVIDAIKDLVQEATLDCTENGISLQAMDNAHVSLVSLLLRSDGFETYRCDRNLSLGLNITSASKILRCASGNDAITLKAGDKADTLTFVFESKSQDRSSEFEIKLMDLDVDHLGIPDTDYKCIIRMPSAQLQRICRDLSQIGDSVVISVAKDGVSFSSNGDLGTGNVKLCQSANADKPEESVSIEMHEPVCMTYSLHYFNIFTKAAPLSSQVVLSLTENVPAVVEFEIEDLGYIRYYLAPKIEDD 258

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BLAST of Proliferating cell nuclear antigen vs. TrEMBL
Match: A0A183K5K8 (Proliferating cell nuclear antigen OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS10282 PE=3 SV=1)

HSP 1 Score: 404.06 bits (1037), Expect = 1.261e-139
Identity = 186/258 (72.09%), Postives = 227/258 (87.98%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L + +VWKKVI+AIKDLVQEATLDC+ENGISLQAMD +HVSLVS+LLRSDGFETYRCDRN++LGLNITS SKIL+    ND++T+KA D ++T++ + ES +++  SE+EIKLMDLD DHLGIPDT+YKCI++MPS++LQRICRDLSQIG+++ I V KDGV+F++ GDLG G +KL Q+++ADK  E V+IEM EPV MTYSL YFN+FTKAAPLSSQV LSLTENVPAV+EF IEDLG+IRYYLAPKIEDD
Sbjct:    1 MFEARLTQADVWKKVIDAIKDLVQEATLDCTENGISLQAMDNAHVSLVSLLLRSDGFETYRCDRNLSLGLNITSASKILRCASGNDAITLKAGDKADTLTFVFESKSQDRSSEFEIKLMDLDVDHLGIPDTDYKCIIRMPSAQLQRICRDLSQIGDSVVISVAKDGVSFSSNGDLGTGNVKLCQSANADKPEESVSIEMHEPVCMTYSLHYFNIFTKAAPLSSQVVLSLTENVPAVVEFEIEDLGYIRYYLAPKIEDD 258

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Cavefish
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:103027123])

HSP 1 Score: 328.176 bits (840), Expect = 3.955e-113
Identity = 145/258 (56.20%), Postives = 208/258 (80.62%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L++G + KKV+EA+KDL+ EA  D S +GISLQ+MD+SHVSLV + LRSDGF++YRCDRN+ +G+N++S+SKILK  G+ D +T++A D++++++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLSQIG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV + ++L Y N FTKA PLS  V+LS++ ++P V+E+ I D+G ++YYLAPKI+++
Sbjct:    1 MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRSDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDNADSLALVFETLNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVMISCAKDGVKFSASGELGTGNIKLSQTSNVDKEEEAVTIEMNEPVQLIFALNYLNFFTKATPLSKTVTLSMSADIPLVVEYKIADMGHVKYYLAPKIDEE 258

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Sea Lamprey
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:30678])

HSP 1 Score: 335.109 bits (858), Expect = 1.672e-116
Identity = 149/259 (57.53%), Postives = 209/259 (80.69%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            MFEA++++G + KKV+EA+KDL+ EA  D S  G+SLQ+MD+SHVSLV + +RSDGF+TYRCDRN+ +G+N+TS+SKILK  G++D +T++A D+++ ++L+ E+ N  ++S+YE+KLMDLD + LGIP+ +Y  +VKMPS +  RICRDLSQIG+++ IC TKDGV F+A+G+LG G IKL+Q S ADKE E VTIEM+E V +T++LRY N FTKA PLS  V+L ++ +VP V+E+ I D+G I+YYLAPKIED+E
Sbjct:    1 MFEARILQGNILKKVLEALKDLITEACWDISSTGVSLQSMDSSHVSLVQLTMRSDGFDTYRCDRNLAMGINLTSMSKILKCAGNDDMITLRAEDNADILTLVFEAQNHEKVSDYEMKLMDLDVEQLGIPEQDYSAVVKMPSGEFSRICRDLSQIGDSVVICCTKDGVKFSASGELGTGNIKLSQTSGADKEEEAVTIEMSEAVQLTFALRYLNFFTKATPLSPTVTLRMSADVPLVVEYGIADMGHIKYYLAPKIEDEE 259

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Yeast
Match: POL30 (Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays a crucial role during Okazaki fragment processing [Source:SGD;Acc:S000000292])

HSP 1 Score: 201.445 bits (511), Expect = 2.445e-64
Identity = 96/259 (37.07%), Postives = 162/259 (62.55%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDDE 850
            M EAK  +  ++K++I+  KD VQ     C E+GI  QA+D S V LVS+ +  + F+ YRCD  V LG+++TS+SKIL+   + D+LT+ A ++ ++I LL E   ++ ++EY +KLMD+D D L I + +Y   + +PSS+  +I RDLSQ+ ++I I +TK+ + F A GD+G G++ +      +     + +EM +PV +T+  +Y     K + LS +V + L+   PA+ +F ++  GF++++LAPK  D+E
Sbjct:    1 MLEAKFEEASLFKRIIDGFKDCVQLVNFQCKEDGIIAQAVDDSRVLLVSLEIGVEAFQEYRCDHPVTLGMDLTSLSKILRCGNNTDTLTLIADNTPDSIILLFEDTKKDRIAEYSLKLMDIDADFLKIEELQYDSTLSLPSSEFSKIVRDLSQLSDSINIMITKETIKFVADGDIGSGSVIIKPFVDMEHPETSIKLEMDQPVDLTFGAKYLLDIIKGSSLSDRVGIRLSSEAPALFQFDLKS-GFLQFFLAPKFNDEE 258

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BLAST of Proliferating cell nuclear antigen vs. Ensembl Medaka
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:101155033])

HSP 1 Score: 328.946 bits (842), Expect = 2.179e-113
Identity = 146/258 (56.59%), Postives = 207/258 (80.23%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAPKIEDD 847
            MFEA+L++G + KKV+EA+KDL+ EA  D S +GISLQ+MD+SHVSLV + LR DGF++YRCDRN+ +G+N++S+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLSQIG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV + ++L Y N FTKA PLS  V+LS++ ++P V+E+ I D+G I+YYLAPKI+++
Sbjct:    1 MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRHDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDAADTLALVFETINQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVMISCAKDGVKFSASGELGTGNIKLSQTSNVDKEEEAVTIEMNEPVQLIFALNYLNFFTKATPLSKTVTLSMSADIPLVVEYKIADMGHIKYYLAPKIDEE 258

[Close]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Medaka
Match: pcna (proliferating cell nuclear antigen [Source:NCBI gene;Acc:101155033])

HSP 1 Score: 299.286 bits (765), Expect = 3.178e-101
Identity = 137/253 (54.15%), Postives = 193/253 (76.28%), Query Frame = 2

Query:   74 MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYYLAP 832
            MFEA+L++G + KKV+EA+KDL+ EA  D S +GISLQ+MD+SHVSLV + LR DGF++YRCDRN+ +G+N++S+SKILK  G+ D +T++A D+++T++L+ E+ N+ ++S+YE+KLMDLD + LGIP+ EY C+VKMPS +  RICRDLSQIG+A+ I   KDGV F+A+G+LG G IKL+Q S+ DKE E VTIEM EPV + ++L Y N FTKA PLS  V+LS++ ++P         LG + Y + P
Sbjct:    1 MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRHDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDAADTLALVFETINQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVMISCAKDGVKFSASGELGTGNIKLSQTSNVDKEEEAVTIEMNEPVQLIFALNYLNFFTKATPLSKTVTLSMSADIP---------LGKVAYVVCP 244

[Close]

BLAST of Proliferating cell nuclear antigen vs. Planmine SMEST
Match: SMESG000046293.1 (SMESG000046293.1)

HSP 1 Score: 261.536 bits (667), Expect = 4.454e-87
Identity = 118/260 (45.38%), Postives = 188/260 (72.31%), Query Frame = 2

Query:   71 IMFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSMLLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETISLLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRDLSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMTEPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDL-GFIRYYLAPKIEDD 847
            ++FEAKL K + +KK+I+++K+L+QEA  +CS  GI LQAMD+SHVSL+ +L++   F +Y+  RNV+LG+++ S+ KILK    NDS+T+K  +  ET+  + ES++ + +SE+ +KL+DLD D L IP+++Y C+  +PS +  +IC+ L+ IG  +TI VTK  + F+ +GD+GKG I LNQ  +  +  + + IE+  P+SM YSLR+F++F+KA  LS++VSLS   N PA++E+ + +L G +R+YLAPK++DD
Sbjct:    1 MLFEAKLNKVDAFKKLIDSVKELIQEAVFECSSKGIELQAMDSSHVSLIFLLIKKQSFSSYKFTRNVSLGVSLVSLCKILKLSQINDSITIKVDNECETVEFVFESSDSDRMSEFSLKLIDLDIDCLAIPESDYDCVATIPSVEFNKICQQLAVIGSTVTIVVTKQSIQFSCSGDMGKGKILLNQTVNKPRIEDSINIEVVNPLSMVYSLRFFHIFSKAYSLSNRVSLSFANNFPALVEYSMNELEGHLRFYLAPKLDDD 260

The following BLAST results are available for this feature:

BLAST of Proliferating cell nuclear antigen vs. Ensembl Human
BLAST of Proliferating cell nuclear antigen vs. Ensembl Celegans
BLAST of Proliferating cell nuclear antigen vs. Ensembl Fly
BLAST of Proliferating cell nuclear antigen vs. Ensembl Zebrafish
BLAST of Proliferating cell nuclear antigen vs. Ensembl Xenopus
BLAST of Proliferating cell nuclear antigen vs. Ensembl Mouse
BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
BLAST of Proliferating cell nuclear antigen vs. TrEMBL
BLAST of Proliferating cell nuclear antigen vs. Ensembl Cavefish
BLAST of Proliferating cell nuclear antigen vs. Ensembl Sea Lamprey
BLAST of Proliferating cell nuclear antigen vs. Ensembl Yeast
BLAST of Proliferating cell nuclear antigen vs. Ensembl Nematostella
BLAST of Proliferating cell nuclear antigen vs. Ensembl Medaka
BLAST of Proliferating cell nuclear antigen vs. Planmine SMEST

BLAST of Proliferating cell nuclear antigen vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
PCNA	4.730e-117	58.30	proliferating cell nuclear antigen [Source:HGNC Sy...	[more]
PCNA	4.730e-117	58.30	proliferating cell nuclear antigen [Source:HGNC Sy...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pcn-1	6.671e-84	44.23	Proliferating cell nuclear antigen [Source:UniPro...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
PCNA	3.196e-118	57.53	gene:FBgn0005655 transcript:FBtr0086308	[more]
PCNA	3.196e-118	57.53	gene:FBgn0005655 transcript:FBtr0086307	[more]
PCNA2	4.958e-88	47.08	gene:FBgn0032813 transcript:FBtr0081262	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pcna	3.474e-113	56.20	proliferating cell nuclear antigen [Source:NCBI ge...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
pcna	5.356e-116	57.14	proliferating cell nuclear antigen [Source:NCBI ge...	[more]
pcna	2.962e-102	56.84	proliferating cell nuclear antigen [Source:NCBI ge...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Pcna	9.832e-116	57.53	proliferating cell nuclear antigen [Source:MGI Sym...	[more]

BLAST of Proliferating cell nuclear antigen vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P17917\|PCNA_DROME	3.204e-117	57.53	Proliferating cell nuclear antigen OS=Drosophila m...	[more]
sp\|P61258\|PCNA_MACFA	2.271e-116	58.30	Proliferating cell nuclear antigen OS=Macaca fasci...	[more]
sp\|P12004\|PCNA_HUMAN	2.271e-116	58.30	Proliferating cell nuclear antigen OS=Homo sapiens...	[more]
sp\|O16852\|PCNA_SARCR	2.701e-116	57.14	Proliferating cell nuclear antigen OS=Sarcophaga c...	[more]
sp\|P57761\|PCNA_CRIGR	1.410e-115	57.92	Proliferating cell nuclear antigen OS=Cricetulus g...	[more]

BLAST of Proliferating cell nuclear antigen vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
Q5H7M5	1.123e-151	83.01	Proliferating cell nuclear antigen OS=Dugesia japo...	[more]
C1L8V7	1.523e-140	72.48	Proliferating cell nuclear antigen OS=Schistosoma ...	[more]
C1L8V9	4.705e-140	72.09	Proliferating cell nuclear antigen OS=Schistosoma ...	[more]
A0A430QDB7	1.261e-139	72.09	Proliferating cell nuclear antigen OS=Schistosoma ...	[more]
A0A183K5K8	1.261e-139	72.09	Proliferating cell nuclear antigen OS=Schistosoma ...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pcna	3.955e-113	56.20	proliferating cell nuclear antigen [Source:NCBI ge...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pcna	1.672e-116	57.53	proliferating cell nuclear antigen [Source:NCBI ge...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
POL30	2.445e-64	37.07	Proliferating cell nuclear antigen (PCNA); functio...	[more]

BLAST of Proliferating cell nuclear antigen vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Proliferating cell nuclear antigen vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
pcna	2.179e-113	56.59	proliferating cell nuclear antigen [Source:NCBI ge...	[more]
pcna	3.178e-101	54.15	proliferating cell nuclear antigen [Source:NCBI ge...	[more]

BLAST of Proliferating cell nuclear antigen vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000046293.1	4.454e-87	45.38	SMESG000046293.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30004304 ID=SMED30004304|Name=Proliferating cell nuclear antigen|organism=Schmidtea mediterranea sexual|type=transcript|length=907bp
CTAAAAGGTAATAATTTAAATTTAATTAGAACATTGTTTTAATATTCGGT
TATATTCTCCATTATTCTAAATTATGTTTGAAGCAAAATTAATAAAAGGC
GAAGTTTGGAAAAAGGTTATAGAAGCTATAAAAGACTTAGTACAAGAAGC
AACATTGGATTGCTCAGAAAATGGAATTAGTCTTCAAGCCATGGATACAT
CTCATGTGTCCTTAGTTAGTATGCTTCTTCGAAGTGATGGTTTTGAGACT
TATCGATGTGATAGAAATGTCAATCTCGGTCTTAATATAACAAGTGTTTC
AAAAATTTTAAAGGCGCTTGGTAGTAATGATTCCCTAACAATGAAAGCCG
CTGATTCAAGTGAAACAATTTCGCTTTTGATAGAATCTGCAAATGAAAAT
GAATTATCTGAATACGAAATAAAATTAATGGACTTGGATGGAGATCACTT
AGGTATACCAGATACTGAATATAAGTGCATTGTGAAAATGCCGAGTTCAA
AGTTACAAAGAATATGTCGAGATTTAAGCCAAATTGGAGAAGCAATCACG
ATTTGTGTTACTAAAGATGGTGTAACTTTTGCTGCTGCTGGAGATCTAGG
AAAAGGAGCTATAAAACTTAATCAAAATTCTAGTGCTGACAAAGAAAATG
AAGGAGTAACTATTGAAATGACCGAACCTGTTTCGATGACATATTCATTG
AGGTATTTCAATATGTTTACAAAGGCTGCACCTCTTTCTTCTCAAGTATC
TCTGTCGTTGACTGAAAATGTTCCAGCAGTTATTGAGTTCATAATCGAAG
ATTTGGGATTTATTCGATATTACCTAGCTCCTAAAATCGAAGACGACGAG
TGAAAGTTTAACTATTAATGTTGTATGTTTAATAGATGTTATTTTGTTTA
AAAAAAA

protein sequence of SMED30004304-orf-1

>SMED30004304-orf-1 ID=SMED30004304-orf-1|Name=SMED30004304-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=260bp
MFEAKLIKGEVWKKVIEAIKDLVQEATLDCSENGISLQAMDTSHVSLVSM
LLRSDGFETYRCDRNVNLGLNITSVSKILKALGSNDSLTMKAADSSETIS
LLIESANENELSEYEIKLMDLDGDHLGIPDTEYKCIVKMPSSKLQRICRD
LSQIGEAITICVTKDGVTFAAAGDLGKGAIKLNQNSSADKENEGVTIEMT
EPVSMTYSLRYFNMFTKAAPLSSQVSLSLTENVPAVIEFIIEDLGFIRYY
LAPKIEDDE*

Aliases

The feature 'Proliferating cell nuclear antigen' has the following synonyms


Synonym
PCNA

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0006259	DNA metabolic process
GO:0006275	regulation of DNA replication
GO:0006260	DNA replication

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0000420	parapharyngeal region
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell
PLANA:0004517	blastomere
PLANA:0000429	neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR000730	Pr_cel_nuc_antig
IPR022648	Pr_cel_nuc_antig_N
IPR022649	Pr_cel_nuc_antig_C
IPR022659	Pr_cel_nuc_antig_CS

Vocabulary: **molecular function**
Term	Definition
GO:0030337	DNA polymerase processivity factor activity
GO:0003677	DNA binding

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

Vocabulary: **Schmidtea mediterranea Developmental Stages**
Term	Definition
PLANA:0000003	Stage 3
PLANA:0000005	Stage 5
PLANA:0000002	Stage 2
PLANA:0000006	Stage 6
PLANA:0000004	Stage 4
PLANA:0000008	Stage 8
PLANA:0000007	Stage 7

Main menu

Proliferating cell nuclear antigen

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

**Cell cycle activity is restricted to piwi-1 blastomeres, and all blastomeres are cycling.**
SPIM reconstructed S4 embryo costained with piwi-1 (red) and PCNA (green). PCNA expression is restricted to piwi-1+ blastomeres, and all piwi-1+ cells co-express PCNA.

**Cell cycle activity is restricted to piwi-1 blastomeres, and all blastomeres are cycling.**
SPIM reconstructed S3 embryo costained with piwi-1 (red) and PCNA (green). PCNA expression is restricted to piwi-1+ blastomeres, and all piwi-1+ cells co-express PCNA.

**Cell cycle activity is restricted to piwi-1 blastomeres, and all blastomeres are cycling.**
SPIM reconstructed S5 embryo costained with piwi-1 (red) and PCNA (green). PCNA expression is restricted to piwi-1+ blastomeres, and all piwi-1+ cells co-express PCNA.

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 36

Owlery

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