Protein kinase
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004241 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Protein kinase vs. Ensembl Human
Match: WNK1 (WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:14540]) HSP 1 Score: 229.565 bits (584), Expect = 1.006e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Human
Match: WNK1 (WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:14540]) HSP 1 Score: 229.565 bits (584), Expect = 1.079e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Human
Match: WNK1 (WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:14540]) HSP 1 Score: 229.565 bits (584), Expect = 1.081e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Human
Match: WNK1 (WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:14540]) HSP 1 Score: 229.565 bits (584), Expect = 1.127e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Human
Match: WNK1 (WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:14540]) HSP 1 Score: 227.254 bits (578), Expect = 3.808e-59 Identity = 140/375 (37.33%), Postives = 208/375 (55.47%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ IA I L LR D + L+ D E++EF D+ ++D+P D+ Q +
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEEDDGEK-------IA-------IKLWLRIEDIKKLKGK-YKDNEAIEFSFDL----ERDVPEDVAQEM 540
BLAST of Protein kinase vs. Ensembl Celegans
Match: wnk-1 (Serine/threonine-protein kinase WNK [Source:UniProtKB/Swiss-Prot;Acc:X5M5N0]) HSP 1 Score: 214.927 bits (546), Expect = 8.239e-56 Identity = 134/386 (34.72%), Postives = 214/386 (55.44%), Query Frame = 3
Query: 570 EAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKW--LREIINSCIHPLSCFRPTAEELFFHPIFQPK---GLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYK-AEDQDIPDLIQNLRLEYED 1706
+A+ + I KSK GR++KF+ ++G G +K V+RG D E VAWCE + ++ E+++ FRE MLK + H +IVR +D +E K IV++ ELM GTLK +K+ F + ++ W QIL L ++H + +PP+IHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM +LE++T P+ EC + K +SG P+ + ++ +REII+ CI R T ++L F P+ G+ VE++ +++D N+ +I ++LR D++ ++ + E L+F DI + D+ + +I+ + ED
Sbjct: 319 DAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQR--FREEAEMLKDLQHPNIVRFYDY------WESADLCGKRKYIVLVTELMTSGTLKMYLKR-FKR----INIKVLKSWCRQILKGLSFLHTR-NPPVIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLND---------LNV----EIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDED 673
BLAST of Protein kinase vs. Ensembl Celegans
Match: wnk-1 (Serine/threonine-protein kinase WNK [Source:UniProtKB/Swiss-Prot;Acc:X5M5N0]) HSP 1 Score: 214.927 bits (546), Expect = 8.239e-56 Identity = 134/386 (34.72%), Postives = 214/386 (55.44%), Query Frame = 3
Query: 570 EAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKW--LREIINSCIHPLSCFRPTAEELFFHPIFQPK---GLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYK-AEDQDIPDLIQNLRLEYED 1706
+A+ + I KSK GR++KF+ ++G G +K V+RG D E VAWCE + ++ E+++ FRE MLK + H +IVR +D +E K IV++ ELM GTLK +K+ F + ++ W QIL L ++H + +PP+IHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM +LE++T P+ EC + K +SG P+ + ++ +REII+ CI R T ++L F P+ G+ VE++ +++D N+ +I ++LR D++ ++ + E L+F DI + D+ + +I+ + ED
Sbjct: 319 DAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQR--FREEAEMLKDLQHPNIVRFYDY------WESADLCGKRKYIVLVTELMTSGTLKMYLKR-FKR----INIKVLKSWCRQILKGLSFLHTR-NPPVIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLND---------LNV----EIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDED 673
BLAST of Protein kinase vs. Ensembl Celegans
Match: wnk-1 (Serine/threonine-protein kinase WNK [Source:UniProtKB/Swiss-Prot;Acc:X5M5N0]) HSP 1 Score: 214.927 bits (546), Expect = 8.605e-56 Identity = 134/386 (34.72%), Postives = 214/386 (55.44%), Query Frame = 3
Query: 570 EAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKW--LREIINSCIHPLSCFRPTAEELFFHPIFQPK---GLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYK-AEDQDIPDLIQNLRLEYED 1706
+A+ + I KSK GR++KF+ ++G G +K V+RG D E VAWCE + ++ E+++ FRE MLK + H +IVR +D +E K IV++ ELM GTLK +K+ F + ++ W QIL L ++H + +PP+IHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM +LE++T P+ EC + K +SG P+ + ++ +REII+ CI R T ++L F P+ G+ VE++ +++D N+ +I ++LR D++ ++ + E L+F DI + D+ + +I+ + ED
Sbjct: 266 DAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQR--FREEAEMLKDLQHPNIVRFYDY------WESADLCGKRKYIVLVTELMTSGTLKMYLKR-FKR----INIKVLKSWCRQILKGLSFLHTR-NPPVIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLND---------LNV----EIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDED 620
BLAST of Protein kinase vs. Ensembl Celegans
Match: wnk-1 (Serine/threonine-protein kinase WNK [Source:UniProtKB/Swiss-Prot;Acc:X5M5N0]) HSP 1 Score: 214.927 bits (546), Expect = 8.841e-56 Identity = 134/386 (34.72%), Postives = 214/386 (55.44%), Query Frame = 3
Query: 570 EAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKW--LREIINSCIHPLSCFRPTAEELFFHPIFQPK---GLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYK-AEDQDIPDLIQNLRLEYED 1706
+A+ + I KSK GR++KF+ ++G G +K V+RG D E VAWCE + ++ E+++ FRE MLK + H +IVR +D +E K IV++ ELM GTLK +K+ F + ++ W QIL L ++H + +PP+IHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM +LE++T P+ EC + K +SG P+ + ++ +REII+ CI R T ++L F P+ G+ VE++ +++D N+ +I ++LR D++ ++ + E L+F DI + D+ + +I+ + ED
Sbjct: 319 DAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQR--FREEAEMLKDLQHPNIVRFYDY------WESADLCGKRKYIVLVTELMTSGTLKMYLKR-FKR----INIKVLKSWCRQILKGLSFLHTR-NPPVIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLND---------LNV----EIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDED 673
BLAST of Protein kinase vs. Ensembl Celegans
Match: wnk-1 (Serine/threonine-protein kinase WNK [Source:UniProtKB/Swiss-Prot;Acc:X5M5N0]) HSP 1 Score: 214.927 bits (546), Expect = 8.841e-56 Identity = 134/386 (34.72%), Postives = 214/386 (55.44%), Query Frame = 3
Query: 570 EAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKW--LREIINSCIHPLSCFRPTAEELFFHPIFQPK---GLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYK-AEDQDIPDLIQNLRLEYED 1706
+A+ + I KSK GR++KF+ ++G G +K V+RG D E VAWCE + ++ E+++ FRE MLK + H +IVR +D +E K IV++ ELM GTLK +K+ F + ++ W QIL L ++H + +PP+IHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM +LE++T P+ EC + K +SG P+ + ++ +REII+ CI R T ++L F P+ G+ VE++ +++D N+ +I ++LR D++ ++ + E L+F DI + D+ + +I+ + ED
Sbjct: 319 DAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQR--FREEAEMLKDLQHPNIVRFYDY------WESADLCGKRKYIVLVTELMTSGTLKMYLKR-FKR----INIKVLKSWCRQILKGLSFLHTR-NPPVIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLND---------LNV----EIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDED 673
BLAST of Protein kinase vs. Ensembl Fly
Match: Wnk (gene:FBgn0037098 transcript:FBtr0346819) HSP 1 Score: 213.001 bits (541), Expect = 4.953e-55 Identity = 136/364 (37.36%), Postives = 198/364 (54.40%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHC-ILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTE--VIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+A S CGR+ K++ ++G G +K VYRG D VAWCE + V E+ + FRE MLK + H +IVR + W I +K IV++ ELM GTLK+ +K+ F + H +LK W QIL L ++H + P IIHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM MLE+ + P+ EC Q+ K +SG P + V D +R+II CI RP+ EL E E ++I R E ++F+++ P+ + I RLRF D + ++ E+++F+ +I E + I
Sbjct: 462 VAMSPCGRFFKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSER--TRFREEADMLKKLQHPNIVRFYTY---WEF-----PIGRKKNIVLVTELMLSGTLKSYLKR-FKKIHPKVLK-----SWCRQILKGLNFLHTRQFP-IIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELL------------ESEFFDEDIGIRVEPTASEQFLSD-PSISIIEFRLRFMDPKKRSSRHKEN-EAIQFEYNIRHDEYEQI 790
BLAST of Protein kinase vs. Ensembl Fly
Match: Wnk (gene:FBgn0037098 transcript:FBtr0346817) HSP 1 Score: 213.001 bits (541), Expect = 4.953e-55 Identity = 136/364 (37.36%), Postives = 198/364 (54.40%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHC-ILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTE--VIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+A S CGR+ K++ ++G G +K VYRG D VAWCE + V E+ + FRE MLK + H +IVR + W I +K IV++ ELM GTLK+ +K+ F + H +LK W QIL L ++H + P IIHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM MLE+ + P+ EC Q+ K +SG P + V D +R+II CI RP+ EL E E ++I R E ++F+++ P+ + I RLRF D + ++ E+++F+ +I E + I
Sbjct: 462 VAMSPCGRFFKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSER--TRFREEADMLKKLQHPNIVRFYTY---WEF-----PIGRKKNIVLVTELMLSGTLKSYLKR-FKKIHPKVLK-----SWCRQILKGLNFLHTRQFP-IIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELL------------ESEFFDEDIGIRVEPTASEQFLSD-PSISIIEFRLRFMDPKKRSSRHKEN-EAIQFEYNIRHDEYEQI 790
BLAST of Protein kinase vs. Ensembl Fly
Match: Wnk (gene:FBgn0037098 transcript:FBtr0347540) HSP 1 Score: 212.616 bits (540), Expect = 5.825e-55 Identity = 136/364 (37.36%), Postives = 198/364 (54.40%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHC-ILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTE--VIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+A S CGR+ K++ ++G G +K VYRG D VAWCE + V E+ + FRE MLK + H +IVR + W I +K IV++ ELM GTLK+ +K+ F + H +LK W QIL L ++H + P IIHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM MLE+ + P+ EC Q+ K +SG P + V D +R+II CI RP+ EL E E ++I R E ++F+++ P+ + I RLRF D + ++ E+++F+ +I E + I
Sbjct: 264 VAMSPCGRFFKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSER--TRFREEADMLKKLQHPNIVRFYTY---WEF-----PIGRKKNIVLVTELMLSGTLKSYLKR-FKKIHPKVLK-----SWCRQILKGLNFLHTRQFP-IIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELL------------ESEFFDEDIGIRVEPTASEQFLSD-PSISIIEFRLRFMDPKKRSSRHKEN-EAIQFEYNIRHDEYEQI 592
BLAST of Protein kinase vs. Ensembl Fly
Match: Wnk (gene:FBgn0037098 transcript:FBtr0346818) HSP 1 Score: 213.001 bits (541), Expect = 6.003e-55 Identity = 136/364 (37.36%), Postives = 198/364 (54.40%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHC-ILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTE--VIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+A S CGR+ K++ ++G G +K VYRG D VAWCE + V E+ + FRE MLK + H +IVR + W I +K IV++ ELM GTLK+ +K+ F + H +LK W QIL L ++H + P IIHRDLK DN F+ G T +VK+GD GLAT + S K+++GT FMAPE+++E YDESVD+YAFGM MLE+ + P+ EC Q+ K +SG P + V D +R+II CI RP+ EL E E ++I R E ++F+++ P+ + I RLRF D + ++ E+++F+ +I E + I
Sbjct: 462 VAMSPCGRFFKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSER--TRFREEADMLKKLQHPNIVRFYTY---WEF-----PIGRKKNIVLVTELMLSGTLKSYLKR-FKKIHPKVLK-----SWCRQILKGLNFLHTRQFP-IIHRDLKCDNIFITGTTG----SVKIGDLGLATLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELL------------ESEFFDEDIGIRVEPTASEQFLSD-PSISIIEFRLRFMDPKKRSSRHKEN-EAIQFEYNIRHDEYEQI 790
BLAST of Protein kinase vs. Ensembl Fly
Match: Madm (gene:FBgn0027497 transcript:FBtr0347493) HSP 1 Score: 100.138 bits (248), Expect = 5.677e-21 Identity = 83/301 (27.57%), Postives = 138/301 (45.85%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGE---GGYKFVYRGYDVEEAKNVAWCEFKREHV-DTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLIT--RWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLG-------FMAPEI-FDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF 1448
+ +S CGRW+K ++ + G V+ D EE V W E + + + K + + M + + +L+++H +IV+ +H Y + +V I E M G+LK +K+ + PL + RW QIL AL Y+H C PPIIH +L D+ F+ VK+G + VH S R+ F APE ++ ++DIYAFGM LE+ ++ + +T+ + I + + R++I C++P RP+A +L FHP+
Sbjct: 97 LEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVK-------FHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAK---RLPLESWRRWCTQILSALSYLH-SCSPPIIHGNLTCDSIFIQHNG-----LVKIGSV-VPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTA-INEETIQ----RTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLL 375
BLAST of Protein kinase vs. Ensembl Zebrafish
Match: si:dkey-151g10.3 (si:dkey-151g10.3 [Source:ZFIN;Acc:ZDB-GENE-090312-81]) HSP 1 Score: 219.55 bits (558), Expect = 6.149e-61 Identity = 122/305 (40.00%), Postives = 181/305 (59.34%), Query Frame = 3
Query: 564 EQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF-QPKGLPVEV 1475
E+EA+ +A+A S GR++KF+I++G G +K VY+G D E VAWCE + + TK ++Q E E++ + H +IVR +D W + +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPI+HRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P + V D ++EII CI R + ++L H F + G+ VE+
Sbjct: 86 EEEAEMKAVATSPGGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----SVLRGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIVHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFDKVNDPEVKEIIEGCIRQNRLERLSVKDLLNHAFFAEDTGVRVEL 371
BLAST of Protein kinase vs. Ensembl Zebrafish
Match: CU041388.2 (pep chromosome:GRCz11:CHR_ALT_CTG23_1_26:25152826:25180312:1 gene:ENSDARG00000115009.1 transcript:ENSDART00000191552.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CU041388.2) HSP 1 Score: 221.09 bits (562), Expect = 9.029e-61 Identity = 122/305 (40.00%), Postives = 181/305 (59.34%), Query Frame = 3
Query: 564 EQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF-QPKGLPVEV 1475
E+EA+ +A+A S GR++KF+I++G G +K VY+G D E VAWCE + + TK ++Q E E++ + H +IVR +D W + +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPI+HRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P + V D ++EII CI R + ++L H F + G+ VE+
Sbjct: 123 EEEAEMKAVATSPGGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----SVLRGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIVHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFDKVNDPEVKEIIEGCIRQNRLERLSVKDLLNHAFFAEDTGVRVEL 408
BLAST of Protein kinase vs. Ensembl Zebrafish
Match: si:dkey-151g10.3 (si:dkey-151g10.3 [Source:ZFIN;Acc:ZDB-GENE-090312-81]) HSP 1 Score: 221.476 bits (563), Expect = 1.339e-60 Identity = 147/433 (33.95%), Postives = 228/433 (52.66%), Query Frame = 3
Query: 564 EQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLV 1862
E+EA+ +A+A S GR++KF+I++G G +K VY+G D E VAWCE + + TK ++Q E E++ + H +IVR +D W + +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPI+HRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P + V D ++EII CI R + ++L H F + V VEL ++ + + R P +L+ + K D E++EF D+ D + + LE + K++ KS D++ L K + + L++HL RR +L + +
Sbjct: 123 EEEAEMKAVATSPGGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----SVLRGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIVHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFDKVNDPEVKEIIEGCIRQNRLERLSVKDLLNHAFFA-EDTGVRVELAEEDTGCKDCLALRIWVEEPK------KLKGKHK---------DNEAIEFSYDLEN-------DSAEEVALEMVKSGFFHESDAKVVGKSI----RDRVTLIKKSRERRLLQHLDERRDSSVLTTSI 509
BLAST of Protein kinase vs. Ensembl Zebrafish
Match: wnk1b (WNK lysine deficient protein kinase 1b [Source:ZFIN;Acc:ZDB-GENE-030131-2656]) HSP 1 Score: 226.483 bits (576), Expect = 4.816e-59 Identity = 140/370 (37.84%), Postives = 203/370 (54.86%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D +E P K IV++ ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT +S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R ++L H FQ + V VEL + D E+I I L LR D + L+ D E++EF D+++ D+PD
Sbjct: 198 EEVETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSRSERQR--FKEEAGMLKGLQHPNIVRFYDS------WESPSK--GRKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLHFLHTRA-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRSSFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNPAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYAIKDLLNHAFFQEE-TGVRVELAEE---DDGEMI-----------AIKLWLRIEDVKKLKG-KYKDNEAIEFSFDLHR----DVPD 527
BLAST of Protein kinase vs. Ensembl Zebrafish
Match: BX321885.1 (WNK lysine deficient protein kinase 1b [Source:NCBI gene;Acc:561159]) HSP 1 Score: 226.483 bits (576), Expect = 4.856e-59 Identity = 140/370 (37.84%), Postives = 203/370 (54.86%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D +E P K IV++ ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT +S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R ++L H FQ + V VEL + D E+I I L LR D + L+ D E++EF D+++ D+PD
Sbjct: 198 EEVETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSRSERQR--FKEEAGMLKGLQHPNIVRFYDS------WESPSK--GRKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLHFLHTRA-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRSSFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNPAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYAIKDLLNHAFFQEE-TGVRVELAEE---DDGEMI-----------AIKLWLRIEDVKKLKG-KYKDNEAIEFSFDLHR----DVPD 527
BLAST of Protein kinase vs. Ensembl Xenopus
Match: WNK3 (WNK lysine deficient protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:14543]) HSP 1 Score: 227.254 bits (578), Expect = 2.980e-59 Identity = 137/367 (37.33%), Postives = 204/367 (55.59%), Query Frame = 3
Query: 582 RAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF-QPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
+A+A S GR++KF+I++G G +K V++G D E VAWCE + + TK ++Q E E++ + H +IVR +D W ++ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P V D ++EII SCI R + +EL H F + GL VE+ D+ +D + + LRL D + L+ D+ E++EF ++ D D PD +
Sbjct: 133 KAVATSPSGRFLKFDIELGRGAFKTVFKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----SSLKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVSDPEVKEIIESCIRQNKAERLSIKELLNHAFFAEDTGLRVEL-AEEDHCTD---------------SSLALRLWVEDPKKLKGKHKDN-EAIEFSFNL----DTDNPDEV 459
BLAST of Protein kinase vs. Ensembl Xenopus
Match: WNK3 (WNK lysine deficient protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:14543]) HSP 1 Score: 226.868 bits (577), Expect = 3.590e-59 Identity = 137/367 (37.33%), Postives = 204/367 (55.59%), Query Frame = 3
Query: 582 RAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF-QPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
+A+A S GR++KF+I++G G +K V++G D E VAWCE + + TK ++Q E E++ + H +IVR +D W ++ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P V D ++EII SCI R + +EL H F + GL VE+ D+ +D + + LRL D + L+ D+ E++EF ++ D D PD +
Sbjct: 133 KAVATSPSGRFLKFDIELGRGAFKTVFKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----SSLKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVSDPEVKEIIESCIRQNKAERLSIKELLNHAFFAEDTGLRVEL-AEEDHCTD---------------SSLALRLWVEDPKKLKGKHKDN-EAIEFSFNL----DTDNPDEV 459
BLAST of Protein kinase vs. Ensembl Xenopus
Match: WNK1 (LIM domain transcription factor LMO4.1 [Source:UniProtKB/Swiss-Prot;Acc:Q5FVB2]) HSP 1 Score: 203.756 bits (517), Expect = 6.234e-52 Identity = 130/364 (35.71%), Postives = 194/364 (53.30%), Query Frame = 3
Query: 585 AIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + S + +L++++N H FQ + V VEL ++ ++ IA I L LR D + L+ D E++EF D+ ++D+PD
Sbjct: 174 AVGFSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYD---SWE-----STLKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKLKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTS----------VSAYLQDLLN------------------HAFFQ-EETGVRVELAEEDDGEK-------IA-------IKLWLRIEDIKKLKGK-YKDNEAIEFSFDL----ERDVPD 469
BLAST of Protein kinase vs. Ensembl Xenopus
Match: gna13 (guanine nucleotide binding protein (G protein), alpha 13 [Source:Xenbase;Acc:XB-GENE-6257775]) HSP 1 Score: 172.17 bits (435), Expect = 1.098e-45 Identity = 112/311 (36.01%), Postives = 163/311 (52.41%), Query Frame = 3
Query: 735 EKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+KRQ E E++ + H +IVR +D W + +K IV++ ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P + V D ++EII CI R ++L H F + V VEL ++ ++ I LRL D + L+ D+G ++EF D+ K +D+
Sbjct: 28 KKRQRFKEEAEMLKGLQHPNIVRFYDF---WE-----SCLKGKKYIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLMFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGVKPASFDKVADPEIKEIIGECICKNKEERYGIKDLLSHAFFA-EDTGVRVELAEEDNGRKSS--------------IALRLWVEDPKKLKVKPKDNG-AIEFTFDLEKETPEDV 304
BLAST of Protein kinase vs. Ensembl Xenopus
Match: gna13 (guanine nucleotide binding protein (G protein), alpha 13 [Source:Xenbase;Acc:XB-GENE-6257775]) HSP 1 Score: 173.711 bits (439), Expect = 8.239e-43 Identity = 112/310 (36.13%), Postives = 162/310 (52.26%), Query Frame = 3
Query: 738 KRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
KRQ E E++ + H +IVR +D W + +K IV++ ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P + V D ++EII CI R ++L H F + V VEL ++ + + I LRL D + L+ D+G ++EF D+ K +D+
Sbjct: 11 KRQRFKEEAEMLKGLQHPNIVRFYDF---WE-----SCLKGKKYIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLMFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGVKPASFDKVADPEIKEIIGECICKNKEERYGIKDLLSHAFFA-EDTGVRVELAEEDNGRK--------------SSIALRLWVEDPKKLKVKPKDNG-AIEFTFDLEKETPEDV 286
BLAST of Protein kinase vs. Ensembl Mouse
Match: Wnk3 (WNK lysine deficient protein kinase 3 [Source:MGI Symbol;Acc:MGI:2652875]) HSP 1 Score: 220.32 bits (560), Expect = 3.418e-60 Identity = 134/365 (36.71%), Postives = 201/365 (55.07%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF-QPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
+A S GR++KF+I++G G +K VY+G D E VAWCE + + TK ++Q E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P V D ++EII CI R + ++L H F + GL VE+ D+ S+ + + LRL D + L+ D+ E++EF ++ + D P+ +
Sbjct: 137 VATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STLKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVEL-AEEDDCSN---------------SSLALRLWVEDPKKLKGKHKDN-EAIEFSFNL----EADTPEEV 461
BLAST of Protein kinase vs. Ensembl Mouse
Match: Wnk1 (WNK lysine deficient protein kinase 1 [Source:MGI Symbol;Acc:MGI:2442092]) HSP 1 Score: 229.565 bits (584), Expect = 6.896e-60 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Mouse
Match: Wnk1 (WNK lysine deficient protein kinase 1 [Source:MGI Symbol;Acc:MGI:2442092]) HSP 1 Score: 229.565 bits (584), Expect = 7.392e-60 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Mouse
Match: Wnk1 (WNK lysine deficient protein kinase 1 [Source:MGI Symbol;Acc:MGI:2442092]) HSP 1 Score: 229.565 bits (584), Expect = 7.408e-60 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. Ensembl Mouse
Match: Wnk1 (WNK lysine deficient protein kinase 1 [Source:MGI Symbol;Acc:MGI:2442092]) HSP 1 Score: 226.483 bits (576), Expect = 4.775e-59 Identity = 140/375 (37.33%), Postives = 208/375 (55.47%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ IA I L LR D + L+ D E++EF D+ ++D+P D+ Q +
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEEDDGEK-------IA-------IKLWLRIEDIKKLKGK-YKDNEAIEFSFDL----ERDVPEDVAQEM 540
BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|Q6R2V0|WNK1_PIG (Serine/threonine-protein kinase WNK1 OS=Sus scrofa OX=9823 GN=WNK1 PE=2 SV=3) HSP 1 Score: 229.565 bits (584), Expect = 4.822e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 203 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 532
BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|P83741|WNK1_MOUSE (Serine/threonine-protein kinase WNK1 OS=Mus musculus OX=10090 GN=Wnk1 PE=1 SV=2) HSP 1 Score: 229.565 bits (584), Expect = 4.823e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|Q9H4A3|WNK1_HUMAN (Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2) HSP 1 Score: 229.565 bits (584), Expect = 4.831e-59 Identity = 136/369 (36.86%), Postives = 203/369 (55.01%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ I L LR D + L+ D E++EF D+ ++D+P+
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE-TGVRVELAEEDDGEK--------------IAIKLWLRIEDIKKLKG-KYKDNEAIEFSFDL----ERDVPE 534
BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|Q9JIH7|WNK1_RAT (Serine/threonine-protein kinase WNK1 OS=Rattus norvegicus OX=10116 GN=Wnk1 PE=1 SV=2) HSP 1 Score: 226.868 bits (577), Expect = 2.607e-58 Identity = 140/375 (37.33%), Postives = 208/375 (55.47%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL ++ ++ IA I L LR D + L+ D E++EF D+ ++D+P D+ Q +
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL-TKSERQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STVKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEEDDGEK-------IA-------IKLWLRIEDIKKLKGK-YKDNEAIEFSFDL----ERDVPEDVAQEM 540
BLAST of Protein kinase vs. UniProt/SwissProt
Match: sp|Q80XP9|WNK3_MOUSE (Serine/threonine-protein kinase WNK3 OS=Mus musculus OX=10090 GN=Wnk3 PE=1 SV=3) HSP 1 Score: 222.246 bits (565), Expect = 5.591e-57 Identity = 134/365 (36.71%), Postives = 201/365 (55.07%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF-QPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
+A S GR++KF+I++G G +K VY+G D E VAWCE + + TK ++Q E E++ + H +IVR +D W T+ +K IV++ ELM GTLK +K+ ++K ++ W QIL L+++H + PPIIHRDLK DN F+ G T +VK+GD GLAT + TS K+++GT FMAPE+++E YDESVD+YAFGM MLE+ T+ P+ EC Q+ K SG P V D ++EII CI R + ++L H F + GL VE+ D+ S+ + + LRL D + L+ D+ E++EF ++ + D P+ +
Sbjct: 137 VATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL-TKAEQQRFKEEAEMLKGLQHPNIVRFYD---SWE-----STLKGKKCIVLVTELMTSGTLKTYLKR-----FKVMKPKVLRSWCRQILKGLQFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVEL-AEEDDCSN---------------SSLALRLWVEDPKKLKGKHKDN-EAIEFSFNL----EADTPEEV 461
BLAST of Protein kinase vs. TrEMBL
Match: A0A4S2M643 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002431 PE=4 SV=1) HSP 1 Score: 810.446 bits (2092), Expect = 0.000e+0 Identity = 365/500 (73.00%), Postives = 421/500 (84.20%), Query Frame = 3
Query: 555 YQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANI-------PNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLV-ANKTAKLTEGE-----MESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYRD 2015
YQ EQEAK R AKSKCGRW+K N+KIGEGGYKFVYRGYD EA+NVAWCEFKREHVDTKEKRQ MF+ETEIMLKMNH HIVRCFDV REW EDP I+EKG+VIIQELMGEGTLK++I+KNFLEG CILKFPLITRWWHQILDALRYMH K PPI+HRDLKADNCFLYG +D+EYLNVKVGDFGLATHV+ SGRKTMLGTLGFMAPEIFDEKYDE VDIYAFGMLMLEVMTNRTP+DEC+T++QVAAKT+SG+GP +++ VL+ LRE+I++CI PL+CFRP+AEEL+FHP+FQPK LPVEVE NYDN +DR EV+DRF+ ++ PN NLRLRFRDK+MLQELGLDDGESLEFDLDIYKAEDQDIPDLI NLRL YEDKL RV++NPK DK +S+HLDKLF SI+LQMQ LVK LLG+RW+ ILDSLV + ++ +G+ + D +SFTII +YKG W++AKR LD+E+ AYR+
Sbjct: 142 YQAEQEAKQRVSAKSKCGRWIKHNLKIGEGGYKFVYRGYDTVEARNVAWCEFKREHVDTKEKRQQMFKETEIMLKMNHPHIVRCFDVFREWIDMEDPNNQIEEKGVVIIQELMGEGTLKSVIRKNFLEGQCILKFPLITRWWHQILDALRYMHHKIQPPILHRDLKADNCFLYGASDEEYLNVKVGDFGLATHVNNSGRKTMLGTLGFMAPEIFDEKYDEKVDIYAFGMLMLEVMTNRTPYDECETVMQVAAKTMSGQGPDIMDKVLNPSLREVISACIQPLTCFRPSAEELYFHPLFQPKTLPVEVEPNYDNATDRAEVLDRFVRSLDVAETRNPN---FNLRLRFRDKKMLQELGLDDGESLEFDLDIYKAEDQDIPDLIHNLRLGYEDKLWRVFENPKQPDKKIVSSHLDKLFNSIRLQMQFLVKVLLGKRWKAILDSLVDEPRVSRKKDGQSALDEDDDSDTDGRETSSFTIIGKYKGKWSRAKRLLDREIQAYRN 638
BLAST of Protein kinase vs. TrEMBL
Match: A0A4S2M682 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002431 PE=4 SV=1) HSP 1 Score: 801.201 bits (2068), Expect = 0.000e+0 Identity = 365/509 (71.71%), Postives = 421/509 (82.71%), Query Frame = 3
Query: 555 YQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQ---------PKGLPVEVELNYDNISDRTEVIDRFIANI-------PNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLV-ANKTAKLTEGE-----MESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYRD 2015
YQ EQEAK R AKSKCGRW+K N+KIGEGGYKFVYRGYD EA+NVAWCEFKREHVDTKEKRQ MF+ETEIMLKMNH HIVRCFDV REW EDP I+EKG+VIIQELMGEGTLK++I+KNFLEG CILKFPLITRWWHQILDALRYMH K PPI+HRDLKADNCFLYG +D+EYLNVKVGDFGLATHV+ SGRKTMLGTLGFMAPEIFDEKYDE VDIYAFGMLMLEVMTNRTP+DEC+T++QVAAKT+SG+GP +++ VL+ LRE+I++CI PL+CFRP+AEEL+FHP+FQ PK LPVEVE NYDN +DR EV+DRF+ ++ PN NLRLRFRDK+MLQELGLDDGESLEFDLDIYKAEDQDIPDLI NLRL YEDKL RV++NPK DK +S+HLDKLF SI+LQMQ LVK LLG+RW+ ILDSLV + ++ +G+ + D +SFTII +YKG W++AKR LD+E+ AYR+
Sbjct: 142 YQAEQEAKQRVSAKSKCGRWIKHNLKIGEGGYKFVYRGYDTVEARNVAWCEFKREHVDTKEKRQQMFKETEIMLKMNHPHIVRCFDVFREWIDMEDPNNQIEEKGVVIIQELMGEGTLKSVIRKNFLEGQCILKFPLITRWWHQILDALRYMHHKIQPPILHRDLKADNCFLYGASDEEYLNVKVGDFGLATHVNNSGRKTMLGTLGFMAPEIFDEKYDEKVDIYAFGMLMLEVMTNRTPYDECETVMQVAAKTMSGQGPDIMDKVLNPSLREVISACIQPLTCFRPSAEELYFHPLFQRYQEGDDSWPKTLPVEVEPNYDNATDRAEVLDRFVRSLDVAETRNPN---FNLRLRFRDKKMLQELGLDDGESLEFDLDIYKAEDQDIPDLIHNLRLGYEDKLWRVFENPKQPDKKIVSSHLDKLFNSIRLQMQFLVKVLLGKRWKAILDSLVDEPRVSRKKDGQSALDEDDDSDTDGRETSSFTIIGKYKGKWSRAKRLLDREIQAYRN 647
BLAST of Protein kinase vs. TrEMBL
Match: A0A4E0RDF5 (Serine:threonine protein kinase WNK1 OS=Fasciola hepatica OX=6192 GN=D915_003672 PE=4 SV=1) HSP 1 Score: 795.423 bits (2053), Expect = 0.000e+0 Identity = 370/517 (71.57%), Postives = 423/517 (81.82%), Query Frame = 3
Query: 555 YQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQ---------PKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKI----NLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDE------GMNSFTIISQYKGMWTKAKRALDKEMVAYRDNSLKDANVSHV 2048
YQ EQEAK + AKSKCGRW+K N+KIGEGGYKFVYRGYD EAKNVAWCEFKREHVDTKEKRQ+MF+ETEIMLKMNH HIVRCFDV REW EDP I+EKG+VIIQELMGEGTLK++I+KNFLEG CILKFPLITRWWHQILDALRYMH K PPI+HRDLKADNCFLYG +D+EYLNVKVGDFGLATHV+ SGRKTMLGTLGFMAPEIFDEKYDE VDIYAFGMLMLEVMTNRTP+DEC+T++QVAAKT+SG+GP ++E VL+ LRE+I++CI PL+CFRPTAEEL+FHP+FQ PK LPVEVE NYDN +DR EV+DRF+ ++ N + NLRLRFRDK+MLQELGLDDGESLEFDLDIYKAEDQDIPDLI NLRL YEDKL RV++NPK DK +S HLDKLF SI+LQMQ LVK LLG+RW+ ILDSLV AK + + D+ +E G SF II QYK WT+AK+ L+KE+ AYR+ + +S V
Sbjct: 133 YQAEQEAKQKISAKSKCGRWIKHNLKIGEGGYKFVYRGYDTMEAKNVAWCEFKREHVDTKEKRQAMFKETEIMLKMNHPHIVRCFDVFREWIDMEDPNNQIEEKGVVIIQELMGEGTLKSVIRKNFLEGQCILKFPLITRWWHQILDALRYMHHKIQPPILHRDLKADNCFLYGASDEEYLNVKVGDFGLATHVNNSGRKTMLGTLGFMAPEIFDEKYDEKVDIYAFGMLMLEVMTNRTPYDECETVLQVAAKTMSGQGPDIMEKVLNPSLREVISACIQPLTCFRPTAEELYFHPLFQRYQEGDDSWPKTLPVEVEPNYDNATDRAEVLDRFVRSLDNAESLNPNFNLRLRFRDKKMLQELGLDDGESLEFDLDIYKAEDQDIPDLIHNLRLGYEDKLWRVFENPKQPDKKIVSNHLDKLFNSIRLQMQFLVKVLLGKRWKAILDSLVVEPRAKKRQDGTSAVDEDEESDADVSGAGSFAIIGQYKSKWTRAKKLLEKEIQAYRNATGAAPTISTV 649
BLAST of Protein kinase vs. TrEMBL
Match: G4VAJ8 (Protein kinase OS=Schistosoma mansoni OX=6183 GN=Smp_154440 PE=4 SV=1) HSP 1 Score: 794.653 bits (2051), Expect = 0.000e+0 Identity = 361/500 (72.20%), Postives = 421/500 (84.20%), Query Frame = 3
Query: 555 YQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNC----TKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEG------MNSFTIISQYKGMWTKAKRALDKEMVAYRDNSL 2024
YQ EQEAK + AKSKC RW+K N+KIGEGGYKFVYRGYD EA+NVAWCEFKREHVDTKEKRQ+MFRETEIMLKMNH HIVRCFDV REW EDP I+EKG+VIIQELMGEGTLK++I+KNFL+G CILKFPLITRWWHQILDALRYMH K PPI+HRDLKADNCFLYG +D+EYLNVKVGDFGLATHV SGRKTMLGTLGFMAPEIFDEKYDE VDIYAFGMLMLEVMTNRTP+DEC+T++QVAAKT+SG+GP +++MV + LRE+I++CI PL+CFRPTA+EL+FHP+FQPK LPVEVE NYDN +DR EV+DRF+ ++ N NLRLRFRDK+MLQELGLDDGESLEFDLDIYKAEDQDIPDLI NLRL YEDKL RV++NPK DK +S+HLDKLF SI+LQMQ LVK LLG+RW+ ILDSLV ++ + + + D+ DE +SFTII +YK W +AK+ L+KE+ AYR++++
Sbjct: 135 YQAEQEAKQKVSAKSKCSRWIKHNLKIGEGGYKFVYRGYDSVEARNVAWCEFKREHVDTKEKRQAMFRETEIMLKMNHPHIVRCFDVFREWIDMEDPNNQIEEKGVVIIQELMGEGTLKSVIRKNFLDGQCILKFPLITRWWHQILDALRYMHHKIQPPILHRDLKADNCFLYGASDEEYLNVKVGDFGLATHVSNSGRKTMLGTLGFMAPEIFDEKYDEKVDIYAFGMLMLEVMTNRTPYDECETVLQVAAKTMSGQGPDIMQMVSNPSLREVISACIQPLTCFRPTADELYFHPLFQPKTLPVEVEPNYDNATDRAEVLDRFVRSLGNPETRNPNFNLRLRFRDKKMLQELGLDDGESLEFDLDIYKAEDQDIPDLIHNLRLGYEDKLWRVFENPKQPDKKVVSSHLDKLFSSIRLQMQFLVKVLLGKRWKAILDSLVQDQPVRKKQEGASTVDEDDESDTDAYDTSSFTIIGKYKSKWNRAKKLLEKEIQAYRNSTI 634
BLAST of Protein kinase vs. TrEMBL
Match: A0A430QPZ3 (WNK lysine deficient protein kinase OS=Schistosoma bovis OX=6184 GN=DC041_0003924 PE=4 SV=1) HSP 1 Score: 794.267 bits (2050), Expect = 0.000e+0 Identity = 362/506 (71.54%), Postives = 424/506 (83.79%), Query Frame = 3
Query: 555 YQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNC----TKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEG------MNSFTIISQYKGMWTKAKRALDKEMVAYRDNSLKDANVS 2042
YQ EQEAK + AKSKC RW+K N+KIGEGGYKFVYRGYD EA+NVAWCEFKREHVDTKEKRQ+MFRETEIMLKMNH HIVRCFDV REW EDP I+EKG+VIIQELMGEGTLK++I+KNFL+G CILKFPLITRWWHQILDALRYMH K PPI+HRDLKADNCFLYG +D+EYLNVKVGDFGLATHV SGRKTMLGTLGFMAPEIFDEKYDE VDIYAFGMLMLEVMTNRTP+DEC+T++QVAAKT+SG+GP +++MV + LRE+I++CI PL+CFRPTA+EL+FHP+FQPK LPVEVE NYDN +DR EV+DRF+ ++ N NLRLRFRDK+MLQELGLDDGESLEFDLDIYKAEDQDIPDLI NLRL YEDKL RV++NPK DK +S+HLDKLF SI+LQMQ LVK LLG+RW+ ILDSLV ++ + + + D+ DE +SFTII +YK W +AK+ L+KE+ AYR++++ ++ S
Sbjct: 135 YQAEQEAKQKVSAKSKCSRWIKHNLKIGEGGYKFVYRGYDSVEARNVAWCEFKREHVDTKEKRQAMFRETEIMLKMNHPHIVRCFDVFREWIDMEDPNNQIEEKGVVIIQELMGEGTLKSVIRKNFLDGQCILKFPLITRWWHQILDALRYMHHKIQPPILHRDLKADNCFLYGASDEEYLNVKVGDFGLATHVSNSGRKTMLGTLGFMAPEIFDEKYDEKVDIYAFGMLMLEVMTNRTPYDECETVLQVAAKTMSGQGPDIMQMVSNPSLREVISACIQPLTCFRPTADELYFHPLFQPKTLPVEVEPNYDNATDRAEVLDRFVRSLGNPETRNPNFNLRLRFRDKKMLQELGLDDGESLEFDLDIYKAEDQDIPDLIHNLRLGYEDKLWRVFENPKQPDKKVVSSHLDKLFSSIRLQMQFLVKVLLGKRWKAILDSLVQDQPVRKKQEGASTIDEDDESDTDAYDTSSFTIIGKYKSKWNRAKKLLEKEIQAYRNSTITVSSAS 640
BLAST of Protein kinase vs. Ensembl Cavefish
Match: wnk4b (serine/threonine-protein kinase WNK4-like [Source:NCBI gene;Acc:103036582]) HSP 1 Score: 236.113 bits (601), Expect = 2.961e-62 Identity = 143/373 (38.34%), Postives = 203/373 (54.42%), Query Frame = 3
Query: 564 EQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQP-KGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
E E + +A+A S GR++KFN++IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR +D W T+ K I+++ ELM GTLK +K+ F E +K L+ RW HQIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDE+VD+YAFGM +LE+ T+ P+ EC Q+ K SG P V L+EII CI R T ++L HP FQ G+ VE+ D + + + L LR D + L D ++EF ++YK D+P+ +
Sbjct: 185 EDEVETKAVATSPDGRFLKFNVEIGRGSFKTVYKGLDTETTVEVAWCELQTRRL-TKVERQRFSEEVEMLKGLQHPNIVRFYD---SWK-----STVKGHKCIILVTELMTSGTLKTYLKR-FKE----MKLKLLQRWSHQILKGLHFLHTRA-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKSASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCILEMTTSEYPYSECQNAAQIYRKVTSGIKPDSFFKVRVPELKEIIEGCIRMNKAERYTIQDLLEHPFFQENNGVHVELAEEDDMVK----------------SGLKLWLRMDDTKKLHG-KYKDNNAIEFLFELYK----DVPEEV 517
BLAST of Protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000001896.2 (serine/threonine-protein kinase WNK1 [Source:NCBI gene;Acc:103038802]) HSP 1 Score: 225.328 bits (573), Expect = 6.315e-59 Identity = 145/376 (38.56%), Postives = 208/376 (55.32%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D W E P +K IV++ ELM GTLK +K+ F E +K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL + D EV+ I L LR D + L+ D E++EF D++K D+P D+ Q +
Sbjct: 194 EEVETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYD---SW---ESPSK--GKKYIVLVTELMTSGTLKTYLKR-FKE----MKIKVLRSWCRQILKGLHFLHTRS-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEE---DDGEVV-----------AIKLWLRIEDVKKLKGK-YKDNEAIEFSFDLHK----DVPEDVAQEM 529
BLAST of Protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000050296.1 (serine/threonine-protein kinase WNK1 [Source:NCBI gene;Acc:103038802]) HSP 1 Score: 225.328 bits (573), Expect = 6.795e-59 Identity = 145/376 (38.56%), Postives = 208/376 (55.32%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D W E P +K IV++ ELM GTLK +K+ F E +K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL + D EV+ I L LR D + L+ D E++EF D++K D+P D+ Q +
Sbjct: 194 EEVETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYD---SW---ESPSK--GKKYIVLVTELMTSGTLKTYLKR-FKE----MKIKVLRSWCRQILKGLHFLHTRS-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEE---DDGEVV-----------AIKLWLRIEDVKKLKGK-YKDNEAIEFSFDLHK----DVPEDVAQEM 529
BLAST of Protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000052131.1 (serine/threonine-protein kinase WNK1 [Source:NCBI gene;Acc:103038802]) HSP 1 Score: 224.942 bits (572), Expect = 8.231e-59 Identity = 145/376 (38.56%), Postives = 208/376 (55.32%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D W E P +K IV++ ELM GTLK +K+ F E +K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL + D EV+ I L LR D + L+ D E++EF D++K D+P D+ Q +
Sbjct: 194 EEVETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYD---SW---ESPSK--GKKYIVLVTELMTSGTLKTYLKR-FKE----MKIKVLRSWCRQILKGLHFLHTRS-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEE---DDGEVV-----------AIKLWLRIEDVKKLKGK-YKDNEAIEFSFDLHK----DVPEDVAQEM 529
BLAST of Protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000041214.1 (serine/threonine-protein kinase WNK1 [Source:NCBI gene;Acc:103038802]) HSP 1 Score: 224.942 bits (572), Expect = 8.908e-59 Identity = 145/376 (38.56%), Postives = 208/376 (55.32%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP-DLIQNL 1688
+E + +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D W E P +K IV++ ELM GTLK +K+ F E +K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + ++L H FQ + V VEL + D EV+ I L LR D + L+ D E++EF D++K D+P D+ Q +
Sbjct: 194 EEVETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYD---SW---ESPSK--GKKYIVLVTELMTSGTLKTYLKR-FKE----MKIKVLRSWCRQILKGLHFLHTRS-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ-EETGVRVELAEE---DDGEVV-----------AIKLWLRIEDVKKLKGK-YKDNEAIEFSFDLHK----DVPEDVAQEM 529
BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001965.1 (pep scaffold:Pmarinus_7.0:GL477178:11064:57293:1 gene:ENSPMAG00000001777.1 transcript:ENSPMAT00000001965.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 166.777 bits (421), Expect = 3.230e-42 Identity = 109/306 (35.62%), Postives = 159/306 (51.96%), Query Frame = 3
Query: 753 FRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
FRE MLK + H IVR +D W T+ + IV++ ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++E YDE+VD+YAFGM MLE+ T+ P+ EC Q+ K +G P V L+EII CI R + ++L H F + V VEL ++ ++ I LRLR D + L+ + E++EF ++ K +++
Sbjct: 14 FREEADMLKGLQHPSIVRFYD---SWE-----STLKGKHSIVLVTELMTSGTLKTYLKR-----FKVMKTKVLQSWCRQILKGLHFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDEAVDVYAFGMCMLEMATSEYPYSECQNPAQIYRKVTTGVKPASFNKVAMPELKEIIEGCIRTNKDERYSIKDLLNHGFFA-EDTGVRVELAEEDDGEK--------------PVIGLRLRVEDPKKLKG-KYKENEAIEFSFELDKDAAEEV 285
BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001973.1 (pep scaffold:Pmarinus_7.0:GL477178:11064:57290:1 gene:ENSPMAG00000001777.1 transcript:ENSPMAT00000001973.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 164.851 bits (416), Expect = 2.995e-41 Identity = 109/306 (35.62%), Postives = 159/306 (51.96%), Query Frame = 3
Query: 753 FRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
FRE MLK + H IVR +D W T+ + IV++ ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++E YDE+VD+YAFGM MLE+ T+ P+ EC Q+ K +G P V L+EII CI R + ++L H F + V VEL ++ ++ I LRLR D + L+ + E++EF ++ K +++
Sbjct: 14 FREEADMLKGLQHPSIVRFYD---SWE-----STLKGKHSIVLVTELMTSGTLKTYLKR-----FKVMKTKVLQSWCRQILKGLHFLHTR-TPPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDEAVDVYAFGMCMLEMATSEYPYSECQNPAQIYRKVTTGVKPASFNKVAMPELKEIIEGCIRTNKDERYSIKDLLNHGFFA-EDTGVRVELAEEDDGEK--------------PVIGLRLRVEDPKKLKG-KYKENEAIEFSFELDKDAAEEV 285
BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: nrbp1 (nuclear receptor binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-041001-146]) HSP 1 Score: 100.523 bits (249), Expect = 9.600e-23 Identity = 87/299 (29.10%), Postives = 133/299 (44.48%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGE---GGYKFVYRGYDVEEAKNVAWCEF----KREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKG-IVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYG----QTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFD-EKYDESVDIYAFGMLMLEV-MTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHP 1442
+ +S CGRW K ++ + G Y G D EE V W E +R + +EK +++F ++ + H++IV+ + + I + K ++ I E M G+LK +KK + H + RW QIL AL Y+H PPIIH +L + F+ + E+ +K A + H + L F+APE D +VDIY+FGM LE+ + P + + Q A + G + D RE I C+ P + RPTA EL FHP
Sbjct: 29 LEESPCGRWQKRREEVSQRNVPGIDSAYLGMDTEEGVEVVWNEVQFSERRNYKAQEEKIKTVFNN---LIHLEHANIVKFHNYWAD---------IKESKARVIFITEYMSSGSLKQFLKKT-KKNHKTMNEKAWKRWCTQILSALGYLH-SFVPPIIHANLTCETIFMQHNGLIKIGSEWYQMKRRLAPGAINDHVKTFRAEQKDLHFLAPEYADLAGMTTAVDIYSFGMCALEMAVLEIQPNGDSTVVSQEAVQAAIGS-------LEDPLQREFIQRCLCPEAPGRPTARELLFHP 306
BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: nrbp1 (nuclear receptor binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-041001-146]) HSP 1 Score: 97.8265 bits (242), Expect = 3.564e-21 Identity = 102/361 (28.25%), Postives = 150/361 (41.55%), Query Frame = 3
Query: 603 CGRWVKFNIKIGE---GGYKFVYRGYDVEEAKNVAWCEFK-REHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKG--IVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGL-ATHVHTSGRKTMLGTLGFMAPEIFD-EKYDESVDIYAFG-----MLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHP----IFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFD 1634
CGRW K ++ + G Y D EE V W E + E + K + + + + ++++ H +IV+ +H Y T I E ++ I E M G+LK +KK + H + RW QIL ALRY+H PPIIH +L D F+ +K+G A H H + L F APE + SVDIY+FG M +LE+ N +C T+V A + I + D RE+I C+ + RPTA L FH + K L LN+ ++ V + PN +R D R ++ L +LE D
Sbjct: 42 CGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIKAVFDNLIQLEHPNIVK-------FHKY---WTDIKENKARVIFITEYMSSGSLKQFLKKT-KKNHKTMNEKAWKRWCTQILSALRYLHSSV-PPIIHGNLTCDTIFMQHNGL-----IKIGSVAPDAIHNHVKTYREEQKNLHFFAPEYGAVGEVTTSVDIYSFGICALEMAVLEIQGN----GDCSTLVSHEAIS------SAINSLEDPLQRELIQRCLCAGAGVRPTARSLLFHAALFEVHSLKLLAAHCFLNHQHLMAENAVEEMTKKIDPNGVLAEIRRVQGDGRQWRQTLLSQVSALELD 375
BLAST of Protein kinase vs. Ensembl Sea Lamprey
Match: nrbp1 (nuclear receptor binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-041001-146]) HSP 1 Score: 95.9005 bits (237), Expect = 3.653e-21 Identity = 87/304 (28.62%), Postives = 132/304 (43.42%), Query Frame = 3
Query: 588 IAKSKCGRWVKFNIKIGE---GGYKFVYRGYDVEEAKNVAWCEF----KREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKG-IVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQT---------DDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFD-EKYDESVDIYAFGMLMLEV-MTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHP 1442
+ +S CGRW K ++ + G Y G D EE V W E +R + +EK +++F ++ + H++IV+ + + I + K ++ I E M G+LK +KK + H + RW QIL AL Y+H PPIIH +L + F+ +L + + HV T + L F+APE D +VDIY+FGM LE+ + P + + Q A + G + D RE I C+ P + RPTA EL FHP
Sbjct: 28 LEESPCGRWQKRREEVSQRNVPGIDSAYLGMDTEEGVEVVWNEVQFSERRNYKAQEEKIKTVFNN---LIHLEHANIVKFHNYWAD---------IKESKARVIFITEYMSSGSLKQFLKKT-KKNHKTMNEKAWKRWCTQILSALGYLH-SFVPPIIHANLTCETIFMQHNGLIKIGSAVWHPNFLLYLLAPGAINDHVKTF--RAEQKDLHFLAPEYADLAGMTTAVDIYSFGMCALEMAVLEIQPNGDSTVVSQEAVQAAIGS-------LEDPLQREFIQRCLCPEAPGRPTARELLFHP 308
BLAST of Protein kinase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 90.5077 bits (223), Expect = 8.549e-19 Identity = 97/367 (26.43%), Postives = 168/367 (45.78%), Query Frame = 3
Query: 633 IGEGGYKFVYRGYD----VEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHV-HTSGRK-TMLGTLGFMAPEIFDEKYDE---SVDIYAFGMLMLEVMTNRTPFDECD--TIVQ-VAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQ---PKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNL 1688
+GEGG+ ++ D + AK VA K E + R+ + E +I M+H +IV+ D D+ + I+ E+ G+L ++K+ +L P + + QI A++YMH + +IHRDLK N F D N+K+GDFGLA + + S RK T+ GT ++APE+ K+ VDI++ G+++ ++ + PF D TI + + + S K I +R+I++ + P+ RP+ E+ + F+ P +P V N D E ++ + N +C + +L L +Q D S++ +D + Q+ P L +L
Sbjct: 88 LGEGGFARCFQIKDDSGEIFAAKTVAKASIKSE-----KTRKKLLSEIQIHKSMSHPNIVQFIDCFE------------DDSNVYILLEICPNGSLMELLKRR-----KVLTEPEVRFFTTQICGAIKYMHSRR---VIHRDLKLGNIFF-----DSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILS--LDPIE--RPSLTEIMDYVWFRGTFPPSIPSTVMSEAPNFEDIPE--EQSLVNFKDCMEKSLLLESMSSDKIQRQKRDYISSIKSSIDKLEEYHQNRPFLPHSL 418
BLAST of Protein kinase vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 89.7373 bits (221), Expect = 2.134e-18 Identity = 60/220 (27.27%), Postives = 108/220 (49.09%), Query Frame = 3
Query: 627 IKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSG--RKTMLGTLGFMAPEIFDEK-YDESVDIYAFGMLMLEVMTNRTPF 1277
+KIG+G VY Y++ +VA K+ +++ + K++ + E +M H +IV D + + + + +I E M G+L +++ HCIL I + L L ++H K ++HRD+K+DN L + D +K+ DFG ++ R TM+GT +MAPE+ K Y VDI++ G++++E++ P+
Sbjct: 624 VKIGQGASGGVYTAYEIGTNVSVA---IKQMNLEKQPKKELIINEILVMKGSKHPNIVNFID------------SYVLKGDLWVIMEYMEGGSLTDVVT------HCILTEGQIGAVCRETLSGLEFLHSKG---VLHRDIKSDNILLSMEGD-----IKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPY 814
BLAST of Protein kinase vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 88.5817 bits (218), Expect = 5.215e-18 Identity = 73/291 (25.09%), Postives = 131/291 (45.02%), Query Frame = 3
Query: 612 WVKFNIKIGEGGYKFVYRGYDVEEA-----KNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATH---VHTSGRKTMLGTLGFMAPEIFDEK--YDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVL---DKWLREIINSCIHPLSCFRPTAEELFFHPI 1445
W+K + IG+G + VY +V K V ++ ++ +++ E + ++H +IV+ + ++Y + E + G++ ++I+ + PLI Q+L L Y+H K I+HRD+KADN L D+ K+ DFG++ ++++ TM GT+ +MAPE+ D K Y VDI++ G ++LE+ + P+ + + + S P + E L + R +++C RPTA EL HP
Sbjct: 1175 WMKGEM-IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYS------------LFLEYVAGGSVGSLIRM-----YGRFDEPLIKHLTTQVLKGLAYLHSKG---ILHRDMKADNLLL-----DQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
BLAST of Protein kinase vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885]) HSP 1 Score: 82.8037 bits (203), Expect = 1.856e-16 Identity = 62/234 (26.50%), Postives = 111/234 (47.44%), Query Frame = 3
Query: 633 IGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGR--KTMLGTLGFMAPEIFDEKY--DESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLS 1322
+GEG + V Y + VA ++ + + + + RE + + H HI++ +DV++ + I+++ E G I++++ + +F + QI+ A+ Y H I+HRDLK +N L DE+LNVK+ DFGL +++ T G KT G+ + APE+ K VD+++ G+++ ++ R PFD D + V K +S
Sbjct: 61 LGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKS------------KDEIIMVIEYAGNELFDYIVQRDKMSEQEARRF------FQQIISAVEYCHRH---KIVHRDLKPENLLL-----DEHLNVKIADFGL-SNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFD--DESIPVLFKNIS 265
BLAST of Protein kinase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 81.6481 bits (200), Expect = 6.057e-16 Identity = 58/200 (29.00%), Postives = 99/200 (49.50%), Query Frame = 3
Query: 876 IIQELMGEGTLKNIIKKNFLE--GHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHV--HTSGRKTMLGTLGFMAPEIFDEK-YDESVDIYAFGMLMLEVMTNRTPF---DECDTIVQVAAK-TLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF 1448
++ E M G+L +II+ + H L P I + L+++H K IIHRD+K+DN L D VK+ DFG + S R TM+GT +MAPE+ ++ YDE +D+++ G++ +E++ P+ D + +A T K P+ + + + ++L + C+ +R + EEL H F
Sbjct: 638 VVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKH---IIHRDIKSDNVLL-----DTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCL--CVD--VRYRASTEELLHHGFF 825
BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO37413 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFU9]) HSP 1 Score: 99.3673 bits (246), Expect = 1.096e-22 Identity = 86/277 (31.05%), Postives = 134/277 (48.38%), Query Frame = 3
Query: 630 KIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKG--IVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPP-IIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVH--TSGRKTMLGTLGFMAPEIFDEK-YDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHP 1442
+IG G Y + ++ K + W E + EK Q + E ++ ++ H HIVR +D IID I I+ E G L +IKK+ E + L+ + +Q++ A++ H + D ++HRDLK N FL D +NVK+GDFGLA + TS KT +GT +M+PE +++ Y+E DI++ G LM E+ PF D I ++ AK G+ I L ++INS + RP+ +EL +P
Sbjct: 14 RIGSGSYGICKKIRRKKDNKVLVWKELDYGQMSETEK-QMLVSEVNLLRELKHPHIVRYYD------------RIIDRTNTTIYIVMEFCENGDLGALIKKHKREKRYTAE-DLVWKLLYQLVLAVQECHRRKDGGHVLHRDLKPANVFL-----DANMNVKLGDFGLARVLSHDTSFAKTFVGTPYYMSPEQVNKRSYNEKSDIWSLGCLMYELCALSPPFTAMDQI-RLEAKIKVGRF-HPIPSHYSSSLSQLINSMLQVNDEMRPSIDELLRNP 269
BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2]) HSP 1 Score: 100.908 bits (250), Expect = 1.781e-21 Identity = 75/295 (25.42%), Postives = 135/295 (45.76%), Query Frame = 3
Query: 612 WVKFNIKIGEGGYKFVYRGYDVEEA-----KNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKK--NFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFG----LATHVHTSG--RKTMLGTLGFMAPEIF-DEKYDESVDIYAFGMLMLEVMTNRTPFD--ECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIF 1448
W K + +G G + Y DV K V++C + D + Q++ E I+ ++ H H+++C R + I E M G++ ++ K F E ++ R+ QIL + Y+H + ++HRD+K N + D ++++ DFG LAT + +G + +LGT+ FMAPE+ E Y S D+++ G +++E+ T + P++ E + + K GP I L+ +R+++ C+ RP A +L HP+F
Sbjct: 577 WKKGEL-LGTGAFSSCYGARDVMTGSLMAVKQVSFCRNSKSEQD--KVCQTIMDEIAILARLKHPHLIKCLGATRHTGHFN------------IFLEWMAGGSISMLLSKYGPFEEA-------ILIRYLRQILQGVSYLH---ENQVVHRDIKGANILV----DSTGQDIRIADFGAAARLATQITGAGEFQGQLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPWNAHEHSNHLALIFKIACAIGPPDIPEHLNPGVRDVVLRCLESKPEDRPAAVDLLQHPLF 842
BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO36110 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJJ9]) HSP 1 Score: 93.2041 bits (230), Expect = 1.573e-19 Identity = 85/291 (29.21%), Postives = 129/291 (44.33%), Query Frame = 3
Query: 594 KSKCGRWVKFNIKIGE---GGYKFVYRGYDVEEAKNVAWCEFK-REHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVI-IQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLAT-HVHTSGRKTMLGTLGFMAPEIFDEKY--DESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHP 1442
+S CGRW K ++ + G Y D EE V W E + E D K + +++ + E +++++H +IV R W + EK VI I E M G+LK +KK + + + RW QIL AL Y+H CD PI+H +L D F+ +K+G T H H + + F+APE + D +VD+YAFGM LE+ + + V A T + +G +E L K + IN C+ RP+ +L P
Sbjct: 30 QSPCGRWEKRRQEVMQRDVPGIDHAYLAMDTEEGVEVVWNEVQFSERKDFKSQEETVKKVFENLIQLDHPNIV---SFHRFW------TDVQGEKARVIFITEYMTSGSLKQFLKKTRKNNYKTMNEKVWKRWCRQILSALSYLH-GCDVPIVHGNLSCDTIFIQHNG-----LIKIGSVAPDTIHNHVKTCREERRNMHFIAPEYGQPGHIVDCAVDVYAFGMCALEMAA--LELHDIEGPVPKEAITQAIQG---LESPLQK---DFINRCLAENPADRPSVRDLLLDP 297
BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO41399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I8]) HSP 1 Score: 85.5001 bits (210), Expect = 1.227e-17 Identity = 74/293 (25.26%), Postives = 132/293 (45.05%), Query Frame = 3
Query: 630 KIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKT-MLGTLGFMAPE-IFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGK------GPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELN 1484
K+G+G Y VY+ + + ++V + ++ +K +++ E E++ + H HIV+ D +W DE I +I E G G L F+ L + ++ Q+ AL+YM + H DLK N L + + +K+ DFG A +H + + + G+ +MAPE I + YD SVD+++ G+++ E + PF + T V++ AK S + GP+V R+++ + + R + E F HP + +P L
Sbjct: 22 KLGQGSYATVYKAFKKGDNRDVVAIKCIKKKTLSKAATENLLTEIELLRNLEHEHIVQLKDF--QW----------DENHIFLIMEYCGGGDL-----SRFIHSKRALPERMARKFLRQLACALQYMR---SYDVAHMDLKPQNLLLSSRHNP---VLKIADFGFAQKLHPNSEASNIRGSPLYMAPEMICCQSYDASVDLWSVGVILYETLFGEPPF-KSKTFVELEAKLRSSEPIKLPPGPRV-----SADCRDLLIALLQRDPKQRISFEAFFTHPFIDMEHMPSSTSLQ 285
BLAST of Protein kinase vs. Ensembl Nematostella
Match: EDO33129 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST31]) HSP 1 Score: 87.0409 bits (214), Expect = 1.953e-17 Identity = 76/295 (25.76%), Postives = 133/295 (45.08%), Query Frame = 3
Query: 666 GYDVEEAKNVAWCEFKREHVDTK----EKRQS----MFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNF-----LEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSG-------RKTMLGTLGFMAPEIFDEK---YDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLD----------KWLREIINSCIHPLSCFRPTAEELFFHPIFQ 1451
GY A CE K E V K EK + M +E M + NH ++V + + + + + I+ L+ G++ ++IK+ L +L+ +I ++L L Y H +IHRD+KA N L TD +V++ DFG+++ + G RKT +GT +MAPE+ +++ Y+ DI++FG+ +E+ T P+ + + +V TL P+ +E D K +++++ C+ RP A EL +P F+
Sbjct: 23 GYGATAVVQAAICESKNERVAIKRIDLEKCGASIDEMMKEIHAMSQCNHENVVNYY------------TSFVVRQELWIVMRLLNGGSMLDVIKQRIKQQPGLVDEGVLEEDIIATVLREVLKGLEYFHKNG---LIHRDVKAGNILL--ATDG---SVQLADFGVSSAISDYGDRTKPKMRKTFVGTPCWMAPEVMEQQVHGYNHKADIWSFGITAIELATGTAPYAKFPAM-KVLMLTLQNDPPR-METCADGSTRDYKKYSKVFKKMVSLCLQKEPANRPDANELLKNPFFK 295
BLAST of Protein kinase vs. Ensembl Medaka
Match: wnk4b (WNK lysine deficient protein kinase 4 [Source:NCBI gene;Acc:101169493]) HSP 1 Score: 226.098 bits (575), Expect = 3.341e-59 Identity = 139/367 (37.87%), Postives = 198/367 (53.95%), Query Frame = 3
Query: 582 RAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQP-KGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
+A+A S GR++KFNI+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR D + T+ K I+++ ELM GTLK +K+ F E +K L+ RW QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDE+VD+YA GM +LE+ T+ P+ EC Q+ K SG P V+ L+EII CI R T ++L HP FQ G+ VE+ D + + + L LR D + L D ++EF ++YK D+P+ +
Sbjct: 163 KAVATSPEGRYLKFNIEIGRGSFKTVYKGLDTETTVEVAWCELQTRKL-TKAERQRFSEEVEMLKGLQHPNIVRFHDSWKS--------TVKGHKCIILVTELMTSGTLKTYLKR-FKE----MKLKLLQRWSRQILKGLHFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKSASFAKSVIGTPEFMAPEMYEEKYDEAVDVYALGMCILEMATSEYPYSECQNAAQIYRKVTSGNKPDSFYKVIVPELKEIIEGCIRMNKDERYTIQDLLDHPFFQENNGVHVELAEEDDLVK----------------SGLKLWLRIDDIKKLHG-KYKDNNAIEFLFELYK----DVPEEV 489
BLAST of Protein kinase vs. Ensembl Medaka
Match: wnk4b (WNK lysine deficient protein kinase 4 [Source:NCBI gene;Acc:101169493]) HSP 1 Score: 226.098 bits (575), Expect = 3.504e-59 Identity = 139/367 (37.87%), Postives = 198/367 (53.95%), Query Frame = 3
Query: 582 RAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQP-KGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLI 1679
+A+A S GR++KFNI+IG G +K VY+G D E VAWCE + + TK +RQ E E++ + H +IVR D + T+ K I+++ ELM GTLK +K+ F E +K L+ RW QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDE+VD+YA GM +LE+ T+ P+ EC Q+ K SG P V+ L+EII CI R T ++L HP FQ G+ VE+ D + + + L LR D + L D ++EF ++YK D+P+ +
Sbjct: 163 KAVATSPEGRYLKFNIEIGRGSFKTVYKGLDTETTVEVAWCELQTRKL-TKAERQRFSEEVEMLKGLQHPNIVRFHDSWKS--------TVKGHKCIILVTELMTSGTLKTYLKR-FKE----MKLKLLQRWSRQILKGLHFLHTRT-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKSASFAKSVIGTPEFMAPEMYEEKYDEAVDVYALGMCILEMATSEYPYSECQNAAQIYRKVTSGNKPDSFYKVIVPELKEIIEGCIRMNKDERYTIQDLLDHPFFQENNGVHVELAEEDDLVK----------------SGLKLWLRIDDIKKLHG-KYKDNNAIEFLFELYK----DVPEEV 489
BLAST of Protein kinase vs. Ensembl Medaka
Match: ENSORLT00000027269.1 (pep primary_assembly:ASM223467v1:8:129429:156272:1 gene:ENSORLG00000026732.1 transcript:ENSORLT00000027269.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 219.164 bits (557), Expect = 3.541e-59 Identity = 135/363 (37.19%), Postives = 198/363 (54.55%), Query Frame = 3
Query: 585 AIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPD 1673
A+A S GR++KFNI+IG G +K VY+G D E VAWCE + H ++ +RQ E E++ + H +IVR FD + + K +++ ELM GTLK +++ F + +K L+ RW Q+L L ++H + PPIIHRDLK DN F+ G + +VK+GD GLAT S K+++GT FMAPE+++EKYDE+VD+YAFGM MLE+ T+ P+ EC + Q+ K +G P V L+EII CI S R T ++L H FQ + V VEL ++ + + L LR DK L+ D +++EF ++YK D+P+
Sbjct: 71 AVASSPDGRFLKFNIEIGRGSFKTVYKGLDTETTVEVAWCELQ-THRLSRAERQRFSEEVEMLKALQHPNIVRFFDSWK--------SALKGHKCTILVTELMTSGTLKMYLRR-FRQ----MKLKLLQRWSFQVLRGLHFLHSR-SPPIIHRDLKCDNIFITGPS----ASVKIGDLGLATLKKASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYHECHSAAQIYRKVTNGIKPDSFFKVEVPELKEIIEGCIRTRSSERFTVQDLLEHSFFQ-ENTGVHVELAEEDDGSK--------------AALKLWLRMDDKEKLRG-KYKDNDAIEFLYELYK----DVPE 394
BLAST of Protein kinase vs. Ensembl Medaka
Match: wnk1b (serine/threonine-protein kinase WNK1 [Source:NCBI gene;Acc:101172041]) HSP 1 Score: 224.557 bits (571), Expect = 1.590e-58 Identity = 140/368 (38.04%), Postives = 201/368 (54.62%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+EA+ +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D +E P +K IV+I ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + L H FQ + V VEL + D E+I I L LR D + L+ D E++EF D+ + +D+
Sbjct: 265 EEAETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYDS------WEGPCK--GKKCIVLITELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLHFLHTRA-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRTNKDERYAIKTLLNHAFFQEE-TGVRVELAEE---DDGEMI-----------AIKLWLRIEDVKKLKG-KYKDNEAIEFSFDLIRDVPEDV 596
BLAST of Protein kinase vs. Ensembl Medaka
Match: wnk1b (serine/threonine-protein kinase WNK1 [Source:NCBI gene;Acc:101172041]) HSP 1 Score: 224.557 bits (571), Expect = 1.689e-58 Identity = 140/368 (38.04%), Postives = 201/368 (54.62%), Query Frame = 3
Query: 567 QEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLK-MNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDI 1667
+EA+ +A+ S GR++KF+I+IG G +K VY+G D E VAWCE + + E+++ F+E MLK + H +IVR +D +E P +K IV+I ELM GTLK +K+ ++K ++ W QIL L ++H + PPIIHRDLK DN F+ G T +VK+GD GLAT S K+++GT FMAPE+++EKYDESVD+YAFGM MLE+ T+ P+ EC Q+ + SG P + V ++EII CI R + L H FQ + V VEL + D E+I I L LR D + L+ D E++EF D+ + +D+
Sbjct: 265 EEAETKAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQR--FKEEAGMLKGLQHPNIVRFYDS------WEGPCK--GKKCIVLITELMTSGTLKTYLKR-----FKVMKIKVLRSWCRQILKGLHFLHTRA-PPIIHRDLKCDNIFITGPTG----SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRTNKDERYAIKTLLNHAFFQEE-TGVRVELAEE---DDGEMI-----------AIKLWLRIEDVKKLKG-KYKDNEAIEFSFDLIRDVPEDV 596
BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000080382.1 (SMESG000080382.1) HSP 1 Score: 2957.16 bits (7665), Expect = 0.000e+0 Identity = 1459/1467 (99.45%), Postives = 1462/1467 (99.66%), Query Frame = 3
Query: 57 MISENQNENDSKKSILKKSEGKPIKKVVSIFINDVGMTNNTISDNTEFEYNQKDPPMFVSEAIFPYTYELEQIKYCNRCTSPDHKFSMEEFLNNLDNKLDVAKVNDTEIVEEMINNGKARHVNCNTLYSNDVTSLHNATVSQDXXXXXXXXXXXXXXXXXXXXXXXYQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYRDNSLKDANVSHVENNFHIDGKLSTNNELIQPEIESLENVILEKPLIENPTYVKAISQSPVEGSISYLNSFTDSEQMDNPNLIQGSVFNQDTLQITSVQGPSLTATTGSNTITMFDSRDLYKETTPVDIITMNKDSQCETDSQKNILNGSYNVKVQNIEFNTHSNLICVTFNVEIPDFSNSESGKWVLCFKCVINENTSIIDNLELNTSDDLAGKIDNDIQLALRETLLCILKMIQNDKKSVLINQNFIFYPIMEKMFLEPLTETNGCKASIRNTVATHDIIVPEDFCIEANTVKSNEHKTISVDHSNIDSNINLDSLFDQENTILLTKRFEDEKYIVKAFSIPCGSAVVINNNGTIQNIRKTTIISPKLDSNENIFVRELDKTDLSMDKAIHILTLLQEKIEELSTKNHNLTDLTSKIIYECKPNMEINKKPQIVDPIDKQKIIEQVLLQKSEIEKLQKQQIELISILSNQQIIVPPDIDQSVISANPNKLISNSEQDILNTQKINNKMFSHFSGQQFINVNPMSMNNDGRLFMQNNMYMTPEDLEYQNSNNFLLDNAIRNQMVHMKTPVNENIIYNSSSNVNKDFVSIDSSMRFKCKKDVPNIGDATRAYSDVSNPYTNDRLEYFDRNIYHQLHYLNNDQIPENDLHCKINPVSSVPNIQERIADFKTPETNLSQQMYSQKYPYFYQIPYQNRRGEQLINFRCPQSMQNYYDPSMFVIGSQYSNPEEQLGNMRKEQLLYDHNTVDDIKLTEINYKEKQLQPDPSLFSVNTNFAAPENPNNCSINQKSLEKPTETCINIQMNPLEEKIKDVFNNR 4457
MISENQNENDSKKSILKKSEGKPIKKVVSIFINDVGMTNNTISDNTEFEYNQKDPPMFVSEAIFPYTYELEQIKYCNRCTSPDHKFSMEEFLNNLDNKLDVAKVNDTEIVEEMINNGKARHVNCNTLYSNDVTSLHNATVSQDKKKTKEERKKEREKKKEEEMLKKYQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYRDNSLKDANVSHVENNFHIDGK STNNELIQPEIESLENVILEKPLIENPTYVKAISQSPVEGSISYLNSFTDSEQMDNPNLIQGSVFNQDTLQITSVQGPSLTATTGSNTITMFDSRDLYKETTPVD ITMNKDSQCETDSQK+ILNGSYNVKVQNIEFNTHSNLICVTFNVEIPDFSNSESGKWVLCFKCVINENTSIIDNLELNTSDDLAGKIDNDIQLALRETLLCILKMIQNDKKSVLINQNFIFYP MEKMFLEPLTETNGCKASIRNTVATHDII+PEDFCIEANTVKSNEHKTISVDHSNIDSNINLDSLFDQENTILLTKRFEDEKYIVKAF IPCGSAVVINNNGTIQNIRKTTIISPKLDSNENIFVRELDKTDLSMDKAIHILTLLQEKIEELSTKNHNLTDLTSKIIYECKPNMEINKKPQIVDPIDKQKIIEQVLLQKSEIEKLQKQQIELISILSNQQIIVPPDIDQSVISANPNKLISNSEQDILNTQKINNKMFSHFSGQQFINVNPMSMNNDGRLFMQNNMYMTPEDLEYQNSNNFLLDNAIRNQMVHMKTPVNENIIYNSSSNVNKDFVSIDSSMRFKCKK+VPNIGDATRAYSDVSNPY NDRLEYFDRNIYHQLHYLNNDQIPENDLHCKINPVSSVPNIQERIADFKTPETNLSQQMYSQKYPYFYQIPYQNRRGEQLINFRCPQSMQNYYDPSMFVIGSQYSNPEEQLGNMRKEQLLYDHNTVDDIKLTEINYKEKQLQPDPSLFSVNTNFAAPENPNNCSINQKSLEKPTETCINIQMNPLEEKIKDVFNNR
Sbjct: 1 MISENQNENDSKKSILKKSEGKPIKKVVSIFINDVGMTNNTISDNTEFEYNQKDPPMFVSEAIFPYTYELEQIKYCNRCTSPDHKFSMEEFLNNLDNKLDVAKVNDTEIVEEMINNGKARHVNCNTLYSNDVTSLHNATVSQDKKKTKEERKKEREKKKEEEMLKKYQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIPNCTKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYRDNSLKDANVSHVENNFHIDGKPSTNNELIQPEIESLENVILEKPLIENPTYVKAISQSPVEGSISYLNSFTDSEQMDNPNLIQGSVFNQDTLQITSVQGPSLTATTGSNTITMFDSRDLYKETTPVDFITMNKDSQCETDSQKDILNGSYNVKVQNIEFNTHSNLICVTFNVEIPDFSNSESGKWVLCFKCVINENTSIIDNLELNTSDDLAGKIDNDIQLALRETLLCILKMIQNDKKSVLINQNFIFYPRMEKMFLEPLTETNGCKASIRNTVATHDIIIPEDFCIEANTVKSNEHKTISVDHSNIDSNINLDSLFDQENTILLTKRFEDEKYIVKAFCIPCGSAVVINNNGTIQNIRKTTIISPKLDSNENIFVRELDKTDLSMDKAIHILTLLQEKIEELSTKNHNLTDLTSKIIYECKPNMEINKKPQIVDPIDKQKIIEQVLLQKSEIEKLQKQQIELISILSNQQIIVPPDIDQSVISANPNKLISNSEQDILNTQKINNKMFSHFSGQQFINVNPMSMNNDGRLFMQNNMYMTPEDLEYQNSNNFLLDNAIRNQMVHMKTPVNENIIYNSSSNVNKDFVSIDSSMRFKCKKEVPNIGDATRAYSDVSNPYINDRLEYFDRNIYHQLHYLNNDQIPENDLHCKINPVSSVPNIQERIADFKTPETNLSQQMYSQKYPYFYQIPYQNRRGEQLINFRCPQSMQNYYDPSMFVIGSQYSNPEEQLGNMRKEQLLYDHNTVDDIKLTEINYKEKQLQPDPSLFSVNTNFAAPENPNNCSINQKSLEKPTETCINIQMNPLEEKIKDVFNNR 1467
BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000046166.1 (SMESG000046166.1) HSP 1 Score: 531.561 bits (1368), Expect = 1.324e-165 Identity = 254/488 (52.05%), Postives = 343/488 (70.29%), Query Frame = 3
Query: 585 AIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKG-------LPVEVELNYDNISDRTEVIDRFIANI--PNC---TKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYR 2012
AI +S CGRWVKF +GEGGYK V++GYD E+ KNVAWCEFK HVDTKEK+ ++ +E EIM+KM+H +IV C+DV E+ + I+ K I++IQEL+GEGTLK++IKKNF+ G IL+F LI W+HQI+DAL YMH K +PPIIHRDLKADNCFL ++ D+YLNVKVGDFGLAT V R TMLGT+GFMAPE++DEKYD VDIYAFGMLMLEV+TNRTP+D+C+T++QVA T+SG+ P + +V D W RE+I+ CIHPL +RPTA EL +HP+F P LPVE+ N D +DR +I FI NI N TK NLR+ FR+K++ + GLD+ ESLEFDLD++K D+D+P+LI NL+ EYE+ L K D +++ L+K F S++LQM+ ++K LLG+RW IL+ L++ ++ D + + F++++ YK W KA + L+ E++ Y+
Sbjct: 132 AIGRSVCGRWVKFRQSLGEGGYKTVFKGYDSEKGKNVAWCEFKPHHVDTKEKQVNIMKEIEIMVKMDHPNIVICYDVFDEYIDLRNLNNPINIKSIILIQELLGEGTLKSVIKKNFINGELILEFSLILYWFHQIIDALAYMHEKLNPPIIHRDLKADNCFLESKSSDKYLNVKVGDFGLATQVSNKERNTMLGTVGFMAPEVYDEKYDIKVDIYAFGMLMLEVLTNRTPYDDCETVMQVAKHTMSGRLPDIFTLVSDPWTREMISCCIHPLPIYRPTAMELLYHPLFIPSYKYKSKNILPVEITPNSDKCTDRETIIKDFIENIVMDNSVFQTKFNLRMEFRNKKIQRSFGLDESESLEFDLDVFK--DEDVPELISNLKSEYEENLREELIANKSSDAKSVNTQLEKFFKSMELQMKFIMKMLLGKRWHFILEGLLSK----------QNDTDVKDDITGFSLLANYKKNWLKATKQLENEILNYQ 607
BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000046166.1 (SMESG000046166.1) HSP 1 Score: 530.406 bits (1365), Expect = 2.018e-165 Identity = 254/488 (52.05%), Postives = 343/488 (70.29%), Query Frame = 3
Query: 585 AIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKG-------LPVEVELNYDNISDRTEVIDRFIANI--PNC---TKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYR 2012
AI +S CGRWVKF +GEGGYK V++GYD E+ KNVAWCEFK HVDTKEK+ ++ +E EIM+KM+H +IV C+DV E+ + I+ K I++IQEL+GEGTLK++IKKNF+ G IL+F LI W+HQI+DAL YMH K +PPIIHRDLKADNCFL ++ D+YLNVKVGDFGLAT V R TMLGT+GFMAPE++DEKYD VDIYAFGMLMLEV+TNRTP+D+C+T++QVA T+SG+ P + +V D W RE+I+ CIHPL +RPTA EL +HP+F P LPVE+ N D +DR +I FI NI N TK NLR+ FR+K++ + GLD+ ESLEFDLD++K D+D+P+LI NL+ EYE+ L K D +++ L+K F S++LQM+ ++K LLG+RW IL+ L++ ++ D + + F++++ YK W KA + L+ E++ Y+
Sbjct: 118 AIGRSVCGRWVKFRQSLGEGGYKTVFKGYDSEKGKNVAWCEFKPHHVDTKEKQVNIMKEIEIMVKMDHPNIVICYDVFDEYIDLRNLNNPINIKSIILIQELLGEGTLKSVIKKNFINGELILEFSLILYWFHQIIDALAYMHEKLNPPIIHRDLKADNCFLESKSSDKYLNVKVGDFGLATQVSNKERNTMLGTVGFMAPEVYDEKYDIKVDIYAFGMLMLEVLTNRTPYDDCETVMQVAKHTMSGRLPDIFTLVSDPWTREMISCCIHPLPIYRPTAMELLYHPLFIPSYKYKSKNILPVEITPNSDKCTDRETIIKDFIENIVMDNSVFQTKFNLRMEFRNKKIQRSFGLDESESLEFDLDVFK--DEDVPELISNLKSEYEENLREELIANKSSDAKSVNTQLEKFFKSMELQMKFIMKMLLGKRWHFILEGLLSK----------QNDTDVKDDITGFSLLANYKKNWLKATKQLENEILNYQ 593
BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000046166.1 (SMESG000046166.1) HSP 1 Score: 530.791 bits (1366), Expect = 5.281e-165 Identity = 254/488 (52.05%), Postives = 343/488 (70.29%), Query Frame = 3
Query: 585 AIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQTIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHVHTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKG-------LPVEVELNYDNISDRTEVIDRFIANI--PNC---TKINLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIPDLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLVANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYR 2012
AI +S CGRWVKF +GEGGYK V++GYD E+ KNVAWCEFK HVDTKEK+ ++ +E EIM+KM+H +IV C+DV E+ + I+ K I++IQEL+GEGTLK++IKKNF+ G IL+F LI W+HQI+DAL YMH K +PPIIHRDLKADNCFL ++ D+YLNVKVGDFGLAT V R TMLGT+GFMAPE++DEKYD VDIYAFGMLMLEV+TNRTP+D+C+T++QVA T+SG+ P + +V D W RE+I+ CIHPL +RPTA EL +HP+F P LPVE+ N D +DR +I FI NI N TK NLR+ FR+K++ + GLD+ ESLEFDLD++K D+D+P+LI NL+ EYE+ L K D +++ L+K F S++LQM+ ++K LLG+RW IL+ L++ ++ D + + F++++ YK W KA + L+ E++ Y+
Sbjct: 166 AIGRSVCGRWVKFRQSLGEGGYKTVFKGYDSEKGKNVAWCEFKPHHVDTKEKQVNIMKEIEIMVKMDHPNIVICYDVFDEYIDLRNLNNPINIKSIILIQELLGEGTLKSVIKKNFINGELILEFSLILYWFHQIIDALAYMHEKLNPPIIHRDLKADNCFLESKSSDKYLNVKVGDFGLATQVSNKERNTMLGTVGFMAPEVYDEKYDIKVDIYAFGMLMLEVLTNRTPYDDCETVMQVAKHTMSGRLPDIFTLVSDPWTREMISCCIHPLPIYRPTAMELLYHPLFIPSYKYKSKNILPVEITPNSDKCTDRETIIKDFIENIVMDNSVFQTKFNLRMEFRNKKIQRSFGLDESESLEFDLDVFK--DEDVPELISNLKSEYEENLREELIANKSSDAKSVNTQLEKFFKSMELQMKFIMKMLLGKRWHFILEGLLSK----------QNDTDVKDDITGFSLLANYKKNWLKATKQLENEILNYQ 641
BLAST of Protein kinase vs. Planmine SMEST
Match: SMESG000070879.1 (SMESG000070879.1) HSP 1 Score: 422.165 bits (1084), Expect = 1.455e-121 Identity = 231/555 (41.62%), Postives = 343/555 (61.80%), Query Frame = 3
Query: 555 YQIEQEAKHRAIAKSKCGRWVKFNIKIGEGGYKFVYRGYDVEEAKNVAWCEFKREHVDTKEKRQSMFRETEIMLKMNHSHIVRCFDVLREWHVYEDPQ--TIIDEKGIVIIQELMGEGTLKNIIKKNFLEGHCILKFPLITRWWHQILDALRYMHLKCDPPIIHRDLKADNCFLYGQTDDEYLNVKVGDFGLATHV-HTSGRKTMLGTLGFMAPEIFDEKYDESVDIYAFGMLMLEVMTNRTPFDECDTIVQVAAKTLSGKGPKVIEMVLDKWLREIINSCIHPLSCFRPTAEELFFHPIFQPKGLPVEVELNYDNISDRTEVIDRFIANIP---NCTK------INLRLRFRDKRMLQELGLDDGESLEFDLDIYKAEDQDIP--DLIQNLRLEYEDKLSRVYDNPKILDKSTISAHLDKLFLSIKLQMQCLVKHLLGRRWRDILDSLV-------------ANKTAKLTEGEMESGDDQDEGMNSFTIISQYKGMWTKAKRALDKEMVAYRDNSLKDANVSHVENNFHIDGKLSTNNELIQPEIESLENVILE 2138
+Q+E++A+ R IA+SKC R++K++ KIGEGGYK VY+G+D + +VAWCE KR+H D KEK+QSMF+E EIMLK++H ++V+CF+VL+ W + D T + KG+VI+QELM EGTLK +IKKNF +G CIL LIT+WW+QILD LRYMH + PPIIHRDLK++NCFL Q +D+ ++VK+GDFGLAT + H S R TM+GT+GFMAPE+++EKYD VDIYAFG+LMLEVMTN+TP+D+C + QV +K++ P VI + ++EII SC+HP+ C+RPTAEEL HP+FQ PV VE D+ ++FIA + N +K ++L++ + + + + E++ DIYK+ ++ DL LE E + S +N LDKL SI+LQ+Q ++K ++G RWR I D+ + N A+ T ++ + N+ + M+ K + L+ E+ +Y +++ + + + F + + TNNE E +S+ + +E
Sbjct: 120 FQLEEKARFRVIAESKCQRFLKYDCKIGEGGYKLVYKGFDRKNCCDVAWCEIKRDHEDNKEKQQSMFKEIEIMLKLDHPNVVKCFNVLKSWWIIHDDMDGTRTEAKGLVIVQELMNEGTLKGMIKKNFHDGLCILDILLITKWWYQILDVLRYMHCRIQPPIIHRDLKSENCFLVVQPNDDCVSVKIGDFGLATTINHNSKRNTMIGTVGFMAPEVYEEKYDTKVDIYAFGILMLEVMTNKTPYDDCRNVFQVVSKSMGRYLPDVISNLKQPLIKEIIMSCVHPIPCYRPTAEELCEHPLFQ--IAPVIVEPFSDD-------ANKFIAVMKLMDNLSKDEVLPILDLKIILKTEFINDKSKDSQFEAVIKSFDIYKSYKANLSTLDLALKTFLEKEIQSSIKKNN-----------QLDKLLTSIRLQIQYIIKTVIGERWRRIFDNFLNKEDRSLITVNNFENMPAEETNVNENDNNENPKLTNNLEEYNFNVSMYHKTTKVLNSEIESY----CQESQIKYFSDIFKLINSIKTNNE----EADSINKISIE 646 The following BLAST results are available for this feature:
BLAST of Protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004241 ID=SMED30004241|Name=Protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=4557bpback to top protein sequence of SMED30004241-orf-1 >SMED30004241-orf-1 ID=SMED30004241-orf-1|Name=SMED30004241-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1468bp MISENQNENDSKKSILKKSEGKPIKKVVSIFINDVGMTNNTISDNTEFEYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
