Dihydropyrimidine dehydrogenase [NADP( )]

Overview
NameDihydropyrimidine dehydrogenase [NADP( )]
Smed IDSMED30004216
Length (bp)3292
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Dihydropyrimidine dehydrogenase [NADP( )] (SMED30004216) t-SNE clustered cells

Violin plots show distribution of expression levels for Dihydropyrimidine dehydrogenase [NADP( )] (SMED30004216) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Dihydropyrimidine dehydrogenase [NADP( )] (SMED30004216) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Dihydropyrimidine dehydrogenase [NADP( )] (SMED30004216) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004216

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30004216h1SMcG0016578 dd_Smed_v4_2037_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30004216h1SMcG0016578 dd_Smed_v4_2037_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30004216h1SMcG0016578 dd_Smed_v4_2037_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated epidermisSMED30004216h1SMcG0016578 dd_Smed_v4_2037_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Human
Match: DPYD (dihydropyrimidine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3012])

HSP 1 Score: 1289.25 bits (3335), Expect = 0.000e+0
Identity = 639/1020 (62.65%), Postives = 793/1020 (77.75%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQN-HFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLL-KSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQN-----------NELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LS+D  DIE++L+LNP+T  +A L  +   K +K  WKRN DKNC  CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT++F+ M IPQIR+P+L     ++    + I L G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K LS N MT+  L  K Y A F+G GLP+     IF  LTQ+QGFYTSK FLP+V++ SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+I+FRKGF  I  VPEEMELAKEEKCEF+PF+SP KV +     +I +M F +T ++E G+   D DQ++ LK D VISAFGS L+D ++ E+L P++ N++GLPE D  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH Y+QS+Y   +   KPELPLFYT ID VD+S+E+ G+KF NPFGLASA P  S SMIRR FEAGWGFA+TKTF+LDKD+VTNVSPRIIRG TSG +YGP Q SFLN+EL+SEK A YW + + EL+ DFP+ ++IASI CS+N++DW +L++  E+ GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV+IPFF KLTPN+T+I+ IARA+ EGGA+GVTATNTVS LM +K +G  WP VG  KRTTYGG+SG AIRPI++RAV++IA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSAIQNQDFT+I+D  TGLKALL+++ IEEL DW+ QSP T  H KGKP+     +  K +P FG +L++R+K II +N           + L + C   +PK+ I  ++++IGK+L  +G F  L+  EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PT+T+ CTGC LC +VCPIVDCI MV +T  +   RGV
Sbjct:    4 VLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKG--GRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSA-KPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKK-IIAENKIRLKEQNVAFSPLKRNC--FIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGV 1017
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Human
Match: DPYD (dihydropyrimidine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3012])

HSP 1 Score: 254.218 bits (648), Expect = 9.085e-78
Identity = 120/160 (75.00%), Postives = 134/160 (83.75%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIF 638
            +LS+D  DIE++L+LNP+T  +A L  +   K +K  WKRN DKNC  CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT+  
Sbjct:    4 VLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATETL 163
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Human
Match: DHODH (dihydroorotate dehydrogenase (quinone) [Source:HGNC Symbol;Acc:HGNC:2867])

HSP 1 Score: 63.1586 bits (152), Expect = 1.268e-9
Identity = 80/330 (24.24%), Postives = 142/330 (43.03%), Query Frame = 3 
Query: 1746 LSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNE---DDWIKLSQMVEEVG--AQALELNLSCPHGMSERGLGLACGQIPRIVIEICQ---WIKKAVKIPFFVKLTPNIT--NILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD 2693
            L + + G KF NP G+A+         +   ++ G+GF    + T  K    N  PR+ R      +   YG N      VE        + L+  Q+ +       L   +    N+   D     ++ V  +G  A  L +N+S P+    R L     ++ R++ ++ Q    +++  +    VK+ P++T  +  DIA    E G  G+  TNT  S    +  G          R+  GG+SG  +R +S + +  +     G  PI+  GG+ S ++AL+ +  GA+ VQ+ +A+      ++  +   L+ALL  QG   ++D
Sbjct:   78 LEVRVLGHKFRNPVGIAAGFDK-HGEAVDGLYKMGFGFVEIGSVT-PKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVE--------HRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSL-QGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVS----RPAGLQGAL-----RSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTD 387
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Human
Match: DHODH (dihydroorotate dehydrogenase (quinone) [Source:HGNC Symbol;Acc:HGNC:2867])

HSP 1 Score: 63.1586 bits (152), Expect = 1.385e-9
Identity = 79/329 (24.01%), Postives = 143/329 (43.47%), Query Frame = 3 
Query: 1746 LSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNE---DDWIKLSQMVEEVG--AQALELNLSCPHGMSERGLGLACGQIPRIVIEICQ---WIKKAVKIPFFVKLTPNIT--NILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD 2693
            L + + G KF NP G+A+         +   ++ G+GF    + T  K    N  PR+ R      +   YG N      VE        + L+  Q+ +       L   +    N+   D     ++ V  +G  A  L +N+S P+    R L     ++ R++ ++ Q    +++  +    VK+ P++T  +  DIA    E G  G+  TNT  S    +  G          R+  GG+SG  +R +S + +  +  ++   PI+  GG+ S ++AL+ +  GA+ VQ+ +A+      ++  +   L+ALL  QG   ++D
Sbjct:   78 LEVRVLGHKFRNPVGIAAGFDK-HGEAVDGLYKMGFGFVEIGSVT-PKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVE--------HRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSL-QGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVS----RPAGLQGAL-----RSETGGLSGKPLRDLSTQTIREMY-ALTQVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTD 385
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Celegans
Match: dpyd-1 (Dihydropyrimidine dehydrogenase [NADP(+)] [Source:UniProtKB/Swiss-Prot;Acc:Q18164])

HSP 1 Score: 1233.78 bits (3191), Expect = 0.000e+0
Identity = 618/1011 (61.13%), Postives = 770/1011 (76.16%), Query Frame = 3 
Query:  153 LLMLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNC-STC--ESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSY--SAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYK-LPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPII--SRKNVPFFGKFLKEREK---DIINQNNELDK-----CCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTE-DCTGCNLCSAVCPIVDCITMVPKT 3134
            L +LS+D PDIE+LL LNPK    A  VPS  TK  K  WKRN +K C STC    L+ +F D+K TTLSERGALKEA RCLKCADAPCQKSCPTQLD+KSFITSI+NKNYYGAA+ I SDNPLGLTCGM+CPTSDLCVGSCNL  +EEG INIGGLQQ+A D+F+QM + QI    ++ +   S++E  + LIGCGPASISCA+FLARLGY+ I I+EK  + GGLS++EIP+FRLPY VVDFE+QL  D+GV +  N+PL K+      LK    +A+F+G G P+ K   +F  LT E GFYTSK +LP V+ +SKPGMC C    LP + G V+VLGAGDTA DCAT ALRCGA RV I FRKGFT I  VPEEME AKEEKCEF+PF +P K+  N    +I S+ F+KT +++NG+   D +QI+ LK D+VISAFGS L +  ++ +L+P ++NK+G  E D  T +T+ + VF GGD+AGVA+TTVE+VNDGK AAW +H Y+QS + N +  T PELP F+T ID+VD+S+++CG+KF NPFGLASAPPT S  M RR FE GWGF +TKT+ LDKDLVTNVSPRI+RG TSG LYGPNQGSF+N+EL+SEK  EYWL+CI+EL++D P +++IASI C +N+ DWI+L+   EE GA  LELNLSCPHGM E+G+GLACGQ P IV EIC+W++  VKIPFF K+TPNIT++ +IARA+ +GGASGVTATNTVSSLMH+K +G AWP +G+ KRTTYGGMSG+AIRPI+M+AVS+IA  + GFPI+ATGGI+SAE  L FL  GA+ +Q+CSA+QNQDFT++DD  TGLKALL++ G E L +W+ QSP   KH KGKPI+   +K +PFFGK+  EREK     ++++N LD          +     +  VE++IGK+L +IG +  L+ +EQ VAIID+DMCINCGKCYM CNDSGYQAI FDPVTH P VTE DCTGC LC +VCPI +CI MVP+T
Sbjct:   14 LPLLSKDSPDIESLLILNPKVQDKANAVPSAVTKKNKHNWKRNEEKGCGSTCGESKLKNDFRDIKHTTLSERGALKEAMRCLKCADAPCQKSCPTQLDVKSFITSISNKNYYGAARQILSDNPLGLTCGMICPTSDLCVGSCNLQASEEGAINIGGLQQYACDVFKQMNVRQIVSKEVRENRNASHKEQ-VALIGCGPASISCASFLARLGYTDITIYEKRAYIGGLSSAEIPQFRLPYDVVDFEIQLARDIGVQIETNRPLGKDGLTLAKLKEQGAAAVFIGIGNPEPKIDPLFEGLTIENGFYTSKNYLPAVAAASKPGMCGCKRTPLPTMRGRVVVLGAGDTAMDCATSALRCGASRVTIAFRKGFTGIRAVPEEMEAAKEEKCEFLPFSAPRKI--NVKDGRIVSIEFNKTEQDDNGKWYEDEEQIVILKCDYVISAFGSTLKEDAVLSALQPCQLNKWGGIEVDSTTQQTSEKWVFAGGDVAGVAETTVESVNDGKIAAWNMHRYIQSLHGNQVSET-PELPQFFTPIDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVSPRIVRGSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIASIMCVYNKADWIELATKSEEAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPFFPKMTPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGSTKRTTYGGMSGSAIRPIAMKAVSSIANELDGFPIMATGGIESAETGLGFLMAGASVLQVCSAVQNQDFTVVDDYCTGLKALLYLSGAESLKNWDGQSPPIEKHQKGKPILLQGQKKMPFFGKYRDEREKLEAIKLSESNLLDTENYHFASRPDTQVSRVPTVEDVIGKALPRIGPYVTLDNQEQKVAIIDDDMCINCGKCYMTCNDSGYQAITFDPVTHQPHVTEDDCTGCTLCYSVCPIPECIEMVPRT 1020
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Celegans
Match: W07E11.1 (pep chromosome:WBcel235:X:10084627:10104252:1 gene:WBGene00012326.1 transcript:W07E11.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:W07E11.1)

HSP 1 Score: 89.3521 bits (220), Expect = 1.280e-17
Identity = 114/472 (24.15%), Postives = 191/472 (40.47%), Query Frame = 3 
Query:  369 KEANRCLKCADAPCQ--KSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXF-----IPFMSPYKVELNKTTNKIHSMAFHKTFENENG------------EIEIDPDQ------------ILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLK----TNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSK 1676
            ++A RC+ C    CQ    CP    I  +   +  KN+  A + +   N      G VCP    C G+C L G     + I  ++    D  F Q  +   +       F T  R   I +IG GP+ +  A  L ++G++ + ++E+ +  GGL    IP  +L   VVD  + L+   GV    N  + K++    LLK   AI +  G   A+++++  +    +G   + ++L   S+  + G       L   +  VI+LG GDTA DC   + R G K V      G   I P P      +    E+     + +      E+  +  + +S++  +     N             ++E + D             I T++ D  I A G    ++ +IE L     N    P  + +T K    +++  VF  GD        V A+++G+QAA  +  YL  K
Sbjct: 1710 EQAARCMDCGVPFCQGHSGCPLGNIIPKWNDFVFKKNWRQALEQLLQTNNFPEFTGRVCPAP--CEGACTL-GIGSPAVTIKSIECAIIDYAFMQGWMKPCKPA-----FNTGKR---IAIIGSGPSGLGAAAQLVKVGHTVV-VYERKNRVGGLLRYGIPTMKLDKFVVDRRVSLLEQEGVRFLTNTEIGKHVPADFLLKENDAIIVCTGSTTARDLNV--EGRDAKGVCFAMEYLE-KSQRRRAGDDVSWEGLDPANKKVIILGGGDTATDCIATSNRLGCKTV------GAFEILPQPGPNRKPENPWPEWPLIFRVDYGHEEAKEMTGSDPRTYSVSTKRFLTTTNAAGITVLTGLEIVDVEWEKDDKGAWKLIEKNETIRTIECDLCILAMGFVGPEKSVIEQL-----NLKTDPRSNILTPKDKYDSDVAKVFAAGDCRRGQSLVVWAIHEGRQAARQVDEYLMGK 2155
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Celegans
Match: W07E11.1 (pep chromosome:WBcel235:X:10084627:10104063:1 gene:WBGene00012326.1 transcript:W07E11.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:W07E11.1)

HSP 1 Score: 89.3521 bits (220), Expect = 1.281e-17
Identity = 114/472 (24.15%), Postives = 191/472 (40.47%), Query Frame = 3 
Query:  369 KEANRCLKCADAPCQ--KSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXF-----IPFMSPYKVELNKTTNKIHSMAFHKTFENENG------------EIEIDPDQ------------ILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLK----TNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSK 1676
            ++A RC+ C    CQ    CP    I  +   +  KN+  A + +   N      G VCP    C G+C L G     + I  ++    D  F Q  +   +       F T  R   I +IG GP+ +  A  L ++G++ + ++E+ +  GGL    IP  +L   VVD  + L+   GV    N  + K++    LLK   AI +  G   A+++++  +    +G   + ++L   S+  + G       L   +  VI+LG GDTA DC   + R G K V      G   I P P      +    E+     + +      E+  +  + +S++  +     N             ++E + D             I T++ D  I A G    ++ +IE L     N    P  + +T K    +++  VF  GD        V A+++G+QAA  +  YL  K
Sbjct: 1720 EQAARCMDCGVPFCQGHSGCPLGNIIPKWNDFVFKKNWRQALEQLLQTNNFPEFTGRVCPAP--CEGACTL-GIGSPAVTIKSIECAIIDYAFMQGWMKPCKPA-----FNTGKR---IAIIGSGPSGLGAAAQLVKVGHTVV-VYERKNRVGGLLRYGIPTMKLDKFVVDRRVSLLEQEGVRFLTNTEIGKHVPADFLLKENDAIIVCTGSTTARDLNV--EGRDAKGVCFAMEYLE-KSQRRRAGDDVSWEGLDPANKKVIILGGGDTATDCIATSNRLGCKTV------GAFEILPQPGPNRKPENPWPEWPLIFRVDYGHEEAKEMTGSDPRTYSVSTKRFLTTTNAAGITVLTGLEIVDVEWEKDDKGAWKLIEKNETIRTIECDLCILAMGFVGPEKSVIEQL-----NLKTDPRSNILTPKDKYDSDVAKVFAAGDCRRGQSLVVWAIHEGRQAARQVDEYLMGK 2165
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Celegans
Match: dhod-1 (Dihydroorotate dehydrogenase (quinone), mitochondrial [Source:UniProtKB/TrEMBL;Acc:O01815])

HSP 1 Score: 50.8322 bits (120), Expect = 4.528e-6
Identity = 79/352 (22.44%), Postives = 143/352 (40.62%), Query Frame = 3 
Query: 1710 LPLF-YTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGA-------QALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKI-------PFFVKLTPNI--TNILDIAR--ASYEGGASGVTATNTVSSLMHIKVNGEAWP-CVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD 2693
            LP F +   +  +L  E+ G +F NP GLA+       ++ +    +G+G     + T       N  PR+ R      +   YG N      V        + W+          P     A    +  ++   + +++  E+G          L LN+S P+       GL   Q    + ++  ++ +A+++         F+K+ P++  + + DIA+   + +    G+  +NT            A P  + ++ +T  GG+SG  +R IS   V  I K   G  PI+  GG+ S  +A + +  GA+ VQ+ SA   + F +I  +   L  LL   G   +S+
Sbjct:   77 LPRFGWNRKEYPELKCELFGREFKNPIGLAAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNN-RPRVFRLLEDEGVINRYGFNSDGVGRVHQRVRSARDSWV----------PESY--AYFGVNLGKNKLTEDAKLDYEIGVNYFAPHCDYLVLNVSSPNTP-----GLRSMQKKSDLEKLLAYVHQALEMHKLEKQPQVFLKIAPDLIESELKDIAQVVTNKKFAIDGIIVSNTTI----------ARPDYLRSENKTETGGLSGAPVREISTECVRKIYKLTNGQIPIIGCGGVFSGADAYEKIRAGASLVQLYSAFVYEGFPVIGKIKRELVELLRKDGFSHVSE 400
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Celegans
Match: dhod-1 (Dihydroorotate dehydrogenase (quinone), mitochondrial [Source:UniProtKB/TrEMBL;Acc:O01815])

HSP 1 Score: 50.8322 bits (120), Expect = 4.528e-6
Identity = 79/352 (22.44%), Postives = 143/352 (40.62%), Query Frame = 3 
Query: 1710 LPLF-YTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGA-------QALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKI-------PFFVKLTPNI--TNILDIAR--ASYEGGASGVTATNTVSSLMHIKVNGEAWP-CVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD 2693
            LP F +   +  +L  E+ G +F NP GLA+       ++ +    +G+G     + T       N  PR+ R      +   YG N      V        + W+          P     A    +  ++   + +++  E+G          L LN+S P+       GL   Q    + ++  ++ +A+++         F+K+ P++  + + DIA+   + +    G+  +NT            A P  + ++ +T  GG+SG  +R IS   V  I K   G  PI+  GG+ S  +A + +  GA+ VQ+ SA   + F +I  +   L  LL   G   +S+
Sbjct:   77 LPRFGWNRKEYPELKCELFGREFKNPIGLAAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNN-RPRVFRLLEDEGVINRYGFNSDGVGRVHQRVRSARDSWV----------PESY--AYFGVNLGKNKLTEDAKLDYEIGVNYFAPHCDYLVLNVSSPNTP-----GLRSMQKKSDLEKLLAYVHQALEMHKLEKQPQVFLKIAPDLIESELKDIAQVVTNKKFAIDGIIVSNTTI----------ARPDYLRSENKTETGGLSGAPVREISTECVRKIYKLTNGQIPIIGCGGVFSGADAYEKIRAGASLVQLYSAFVYEGFPVIGKIKRELVELLRKDGFSHVSE 400
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Fly
Match: su(r) (gene:FBgn0086450 transcript:FBtr0071338)

HSP 1 Score: 1179.08 bits (3049), Expect = 0.000e+0
Identity = 591/1023 (57.77%), Postives = 759/1023 (74.19%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPL-SKNMTVKDLLKS-YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCAC--SYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD---WNYQSPKTSKHYKGKPII-----SRKNVPFFGKFLKERE---KDIINQ-----NNELDKCCP--SNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LS+D PDIE+LLSLNP+      +VP+  TK  K  WKRN D     C +L  +F+D+K TTLSERGAL+EA RCLKCADAPCQKSCPTQLDIKSFITSIANKN+YGAAK IFSDNPLGLTCGMVCPTSDLCVG CNL  +E GPINIGGLQQFAT++F++M + Q R P  + + L+      I L+G GPAS+SCATFLARLGY  + I+E+  + GGLS +EIP++RLP   V+FE+ L+ DLGV +   + L +K++T++ LL + + A+F+G GLP+ K   IF  L    GFYTSK FLP+VS  SKPG+CAC  +  LP+LHGNVIVLGAGDTAFDCAT ALRCGA+RV+++FRKG + I  VPEE+ELA++E+CE +P++SP KV +      I +M F +T +NEN E   D +Q   LK +FVISAFGS L DQ++  +L P++  +  LP  D++T++++++ VF GGDLAGVA TTVE+VNDGK AAW IH  LQ     P+D T   LPLFYT ID VD+S+E+CGI+F NPFGLASAPPT S +MIRR FE GWGF VTKTF LDKDLVTNVSPRI+RG TSG  YGP QG FLN+EL+SEK+AEYWLK I EL++DFP +++IASI CS NE+DW +L+   E+ GA ALELNLSCPHGM ERG+GLACGQ P +V +I +W++KAVK+PFF+KLTPNIT+I+ IA A+  GGA G +A NTV  LM +K +  AWP +G ++RTTYGG+SGNA RP++++A+S IA  +PGFPIL  GGIDS E AL+F++ GA  +QICS++QNQDFT+I+D  T LKALL+++      D   W+ QSP T  H KGKP++      +  + FFG + ++R+    ++ +Q     + E  K  P  SN       +++++IG +L++IG +  L+ ++Q VA+ID+DMCINCGKCYM C DSGYQAI+FD  THIP V +DCTGC LC +VCPI+DCITMVPK I HV+ RGV
Sbjct:    6 LLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIKHTTLSERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTPQAEANPLSQ----KIALVGGGPASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSLGTKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKAAAGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLPYLSPRKVIVKD--GLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAPLQF-RGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQGL---PLD-TPAALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVTNVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEEDWTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPNITDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAISDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKANPPPVDGPFWDGQSPPTPVHQKGKPVVRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDAEQVKATPPASNGAPNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCADSGYQAIEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGV 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Fly
Match: CG9674 (gene:FBgn0036663 transcript:FBtr0333608)

HSP 1 Score: 100.908 bits (250), Expect = 4.856e-21
Identity = 114/467 (24.41%), Postives = 193/467 (41.33%), Query Frame = 3 
Query:  372 EANRCLKCADAPCQKS---CPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQM----KIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFN-DLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPY---KVELNKTTNKIHSMAFHKTFENENGEIE-IDPDQILTLKT-------------------DFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSK 1676
            +A RC++C    CQ +   CP    I  +   + +  +  A + +   N      G VCP    C GSC L G  E  + I  ++    D  F Q     +IP++R         T  R   + ++G GP+ ++ +  L R G+  + +FE+ D  GGL    IP  +L  +VV   + LM D G+    N  + K++  + LL+ Y A+ L  G    +++ + N DL   +G + + +FL       K  +   +  +     NVI++G GDT  DC   +LR GAK +       F  +   P++             F   Y   +V+L    +        K F  ENG I+ ++  ++   KT                   D ++ A G  L  ++ + S   + ++  G  +       T+   VF  GD        V A+ +G+QAA  + +YL  +
Sbjct: 1663 QAARCMECGVPFCQSNSTGCPLGNIIPKWNDLVFHGEWQEALRQLLQTNNFPEFTGRVCPAP--CEGSCVL-GISEPAVTIKNIECAIIDHAFEQGWIKPEIPEVR---------TGKR---VAIVGSGPSGLAASQQLNRAGHF-VTVFERNDRVGGLLQYGIPTMKLSKEVVKRRVDLMADEGIEFRTNVHVGKDLKAEQLLQEYDAVLLTTGSTWPRDLPLANRDL---KGIHFAMEFL---EAQQKKQLGGKNDIISAAGKNVIIIGGGDTGCDCIATSLRQGAKSITT-----FEILPEPPQKRAQDNPWPQWPKVFRVDYGHEEVKLKWGKDPRQYCTTTKEFVGENGAIKGVNTVEVEWTKTETGQWRMQEVAGSEKYFPADLILLAMG-FLGPEKTVPSELGLELDPRGNIKASNGQYGTSNSKVFAAGDCRRGQSLVVWAITEGRQAARQVDSYLTGR 2101
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Fly
Match: CG9674 (gene:FBgn0036663 transcript:FBtr0305916)

HSP 1 Score: 100.908 bits (250), Expect = 4.856e-21
Identity = 114/467 (24.41%), Postives = 193/467 (41.33%), Query Frame = 3 
Query:  372 EANRCLKCADAPCQKS---CPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQM----KIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFN-DLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPY---KVELNKTTNKIHSMAFHKTFENENGEIE-IDPDQILTLKT-------------------DFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSK 1676
            +A RC++C    CQ +   CP    I  +   + +  +  A + +   N      G VCP    C GSC L G  E  + I  ++    D  F Q     +IP++R         T  R   + ++G GP+ ++ +  L R G+  + +FE+ D  GGL    IP  +L  +VV   + LM D G+    N  + K++  + LL+ Y A+ L  G    +++ + N DL   +G + + +FL       K  +   +  +     NVI++G GDT  DC   +LR GAK +       F  +   P++             F   Y   +V+L    +        K F  ENG I+ ++  ++   KT                   D ++ A G  L  ++ + S   + ++  G  +       T+   VF  GD        V A+ +G+QAA  + +YL  +
Sbjct: 1663 QAARCMECGVPFCQSNSTGCPLGNIIPKWNDLVFHGEWQEALRQLLQTNNFPEFTGRVCPAP--CEGSCVL-GISEPAVTIKNIECAIIDHAFEQGWIKPEIPEVR---------TGKR---VAIVGSGPSGLAASQQLNRAGHF-VTVFERNDRVGGLLQYGIPTMKLSKEVVKRRVDLMADEGIEFRTNVHVGKDLKAEQLLQEYDAVLLTTGSTWPRDLPLANRDL---KGIHFAMEFL---EAQQKKQLGGKNDIISAAGKNVIIIGGGDTGCDCIATSLRQGAKSITT-----FEILPEPPQKRAQDNPWPQWPKVFRVDYGHEEVKLKWGKDPRQYCTTTKEFVGENGAIKGVNTVEVEWTKTETGQWRMQEVAGSEKYFPADLILLAMG-FLGPEKTVPSELGLELDPRGNIKASNGQYGTSNSKVFAAGDCRRGQSLVVWAITEGRQAARQVDSYLTGR 2101
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Fly
Match: CG9674 (gene:FBgn0036663 transcript:FBtr0075344)

HSP 1 Score: 100.908 bits (250), Expect = 4.980e-21
Identity = 114/467 (24.41%), Postives = 193/467 (41.33%), Query Frame = 3 
Query:  372 EANRCLKCADAPCQKS---CPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQM----KIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFN-DLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPY---KVELNKTTNKIHSMAFHKTFENENGEIE-IDPDQILTLKT-------------------DFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSK 1676
            +A RC++C    CQ +   CP    I  +   + +  +  A + +   N      G VCP    C GSC L G  E  + I  ++    D  F Q     +IP++R         T  R   + ++G GP+ ++ +  L R G+  + +FE+ D  GGL    IP  +L  +VV   + LM D G+    N  + K++  + LL+ Y A+ L  G    +++ + N DL   +G + + +FL       K  +   +  +     NVI++G GDT  DC   +LR GAK +       F  +   P++             F   Y   +V+L    +        K F  ENG I+ ++  ++   KT                   D ++ A G  L  ++ + S   + ++  G  +       T+   VF  GD        V A+ +G+QAA  + +YL  +
Sbjct: 1662 QAARCMECGVPFCQSNSTGCPLGNIIPKWNDLVFHGEWQEALRQLLQTNNFPEFTGRVCPAP--CEGSCVL-GISEPAVTIKNIECAIIDHAFEQGWIKPEIPEVR---------TGKR---VAIVGSGPSGLAASQQLNRAGHF-VTVFERNDRVGGLLQYGIPTMKLSKEVVKRRVDLMADEGIEFRTNVHVGKDLKAEQLLQEYDAVLLTTGSTWPRDLPLANRDL---KGIHFAMEFL---EAQQKKQLGGKNDIISAAGKNVIIIGGGDTGCDCIATSLRQGAKSITT-----FEILPEPPQKRAQDNPWPQWPKVFRVDYGHEEVKLKWGKDPRQYCTTTKEFVGENGAIKGVNTVEVEWTKTETGQWRMQEVAGSEKYFPADLILLAMG-FLGPEKTVPSELGLELDPRGNIKASNGQYGTSNSKVFAAGDCRRGQSLVVWAITEGRQAARQVDSYLTGR 2100
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Fly
Match: CG9674 (gene:FBgn0036663 transcript:FBtr0075341)

HSP 1 Score: 100.908 bits (250), Expect = 4.980e-21
Identity = 114/467 (24.41%), Postives = 193/467 (41.33%), Query Frame = 3 
Query:  372 EANRCLKCADAPCQKS---CPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQM----KIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFN-DLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPY---KVELNKTTNKIHSMAFHKTFENENGEIE-IDPDQILTLKT-------------------DFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSK 1676
            +A RC++C    CQ +   CP    I  +   + +  +  A + +   N      G VCP    C GSC L G  E  + I  ++    D  F Q     +IP++R         T  R   + ++G GP+ ++ +  L R G+  + +FE+ D  GGL    IP  +L  +VV   + LM D G+    N  + K++  + LL+ Y A+ L  G    +++ + N DL   +G + + +FL       K  +   +  +     NVI++G GDT  DC   +LR GAK +       F  +   P++             F   Y   +V+L    +        K F  ENG I+ ++  ++   KT                   D ++ A G  L  ++ + S   + ++  G  +       T+   VF  GD        V A+ +G+QAA  + +YL  +
Sbjct: 1662 QAARCMECGVPFCQSNSTGCPLGNIIPKWNDLVFHGEWQEALRQLLQTNNFPEFTGRVCPAP--CEGSCVL-GISEPAVTIKNIECAIIDHAFEQGWIKPEIPEVR---------TGKR---VAIVGSGPSGLAASQQLNRAGHF-VTVFERNDRVGGLLQYGIPTMKLSKEVVKRRVDLMADEGIEFRTNVHVGKDLKAEQLLQEYDAVLLTTGSTWPRDLPLANRDL---KGIHFAMEFL---EAQQKKQLGGKNDIISAAGKNVIIIGGGDTGCDCIATSLRQGAKSITT-----FEILPEPPQKRAQDNPWPQWPKVFRVDYGHEEVKLKWGKDPRQYCTTTKEFVGENGAIKGVNTVEVEWTKTETGQWRMQEVAGSEKYFPADLILLAMG-FLGPEKTVPSELGLELDPRGNIKASNGQYGTSNSKVFAAGDCRRGQSLVVWAITEGRQAARQVDSYLTGR 2100
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Zebrafish
Match: dpydb (dihydropyrimidine dehydrogenase b [Source:NCBI gene;Acc:405829])

HSP 1 Score: 1285.78 bits (3326), Expect = 0.000e+0
Identity = 624/1023 (61.00%), Postives = 785/1023 (76.74%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL--QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLK--SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELD-------KCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY*N*MC 3179
            MLS++L DIE++L+LNP+   +A +  +   K+EK  WKRN +++C +C +LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSI+NKNYYGAAK I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQIR+P L   ++   S+  + I LIGCGPASISCA+FLARLGY  I IFEK  + GGLSTSEIP+FRLPY+VV FE+ LM DLGV + L K L +N      LK   Y  +F+G GLP A    IF  LT EQGFYTSK FLP+V+++SK GMC C  +LP+LHGNVIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT I  VPEEME AKEEKCEF+PF+SP+  E+ K   ++  + F +T + E+G   +D +QI+ LK DF+ISAFGS L D  + ++L P+++N++G PE +  T++T    VF GGD+AG A TTVE+VNDGKQA+W+IH Y+QS + N I  T P LPLF+ AID VD+S+E+CGIKFPNPFGLASAPPT SA+MIRR FE GWGFA+TKTF LDKDLVTNVSPRI+RG TSG ++GP QGSFLN+EL+SEK A YW K + EL+ DFP  ++IASI CS+N+ DW +L++M +E  A ALELNLSCPHGM ERG+GLACGQ P +V  IC+W++KA  IPFF KLTPN+TNI+DIA A+YEGGA GVTATNTVS LM +K +   WP +G   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D   GLKALL+++ IEEL DW+ QSP T +H KGKP+     +  K++P FG +L+ + + +     +              N+PKK I  V+++I ++L  IG ++ L+  EQV A++D +MCINCGKCYM CNDSGYQAIKFDP TH+P +T+ CTGC LC +VCPI+DCI MV +T  +   RG+  N +C
Sbjct:    4 MLSKELQDIESILALNPRVKSHANVHSTASKKNEKKHWKRNPERSCDSCVNLENNFDDIKHTTLSERGALREALRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQIRNPELPTADNMPKSF-HTRIALIGCGPASISCASFLARLGYDNITIFEKQKYIGGLSTSEIPQFRLPYEVVQFEIDLMKDLGVKVVLEKGLGQNGLTLTSLKEEGYQVVFIGIGLPQANRDKIFEGLTTEQGFYTSKDFLPLVAKASKIGMCNCRSQLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMEAAKEEKCEFLPFLSPH--EVMKKNGRVSGLRFCRTEQQEDGTWIVDEEQIVHLKADFIISAFGSMLNDPAVTKALDPIKLNRWGTPEVNSETMQTTEPWVFAGGDIAGFANTTVESVNDGKQASWHIHKYIQSLHGNTISAT-PRLPLFHCAIDTVDISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIVRGTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSYNQADWTELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRKATSIPFFAKLTPNVTNIVDIATAAYEGGADGVTATNTVSGLMALKADATPWPGIGRGARTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTVIEDYCLGLKALLYLKSIEELHDWDGQSPPTIRHQKGKPVPHVSELIGKSLPSFGPYLQTKTQALAKYKKDASGDVIMDTGAARVNIPKKPIPNVKDVIARALRHIGAYQELDNTEQVQALVDPEMCINCGKCYMTCNDSGYQAIKFDPETHLPVITDSCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPVNPVC 1022
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Zebrafish
Match: dpydb (dihydropyrimidine dehydrogenase b [Source:NCBI gene;Acc:405829])

HSP 1 Score: 1240.33 bits (3208), Expect = 0.000e+0
Identity = 604/980 (61.63%), Postives = 754/980 (76.94%), Query Frame = 3 
Query:  288 KNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL--QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLK--SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELD-------KCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY*N*MC 3179
            ++  +C +LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSI+NKNYYGAAK I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQIR+P L   ++   S+  + I LIGCGPASISCA+FLARLGY  I IFEK  + GGLSTSEIP+FRLPY+VV FE+ LM DLGV + L K L +N      LK   Y  +F+G GLP A    IF  LT EQGFYTSK FLP+V+++SK GMC C  +LP+LHGNVIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT I  VPEEME AKEEKCEF+PF+SP+  E+ K   ++  + F +T + E+G   +D +QI+ LK DF+ISAFGS L D  + ++L P+++N++G PE +  T++T    VF GGD+AG A TTVE+VNDGKQA+W+IH Y+QS + N I  T P LPLF+ AID VD+S+E+CGIKFPNPFGLASAPPT SA+MIRR FE GWGFA+TKTF LDKDLVTNVSPRI+RG TSG ++GP QGSFLN+EL+SEK A YW K + EL+ DFP  ++IASI CS+N+ DW +L++M +E  A ALELNLSCPHGM ERG+GLACGQ P +V  IC+W++KA  IPFF KLTPN+TNI+DIA A+YEGGA GVTATNTVS LM +K +   WP +G   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D   GLKALL+++ IEEL DW+ QSP T +H KGKP+     +  K++P FG +L+ + + +     +              N+PKK I  V+++I ++L  IG ++ L+  EQV A++D +MCINCGKCYM CNDSGYQAIKFDP TH+P +T+ CTGC LC +VCPI+DCI MV +T  +   RG+  N +C
Sbjct:   10 QDIESCVNLENNFDDIKHTTLSERGALREALRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQIRNPELPTADNMPKSFH-TRIALIGCGPASISCASFLARLGYDNITIFEKQKYIGGLSTSEIPQFRLPYEVVQFEIDLMKDLGVKVVLEKGLGQNGLTLTSLKEEGYQVVFIGIGLPQANRDKIFEGLTTEQGFYTSKDFLPLVAKASKIGMCNCRSQLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMEAAKEEKCEFLPFLSPH--EVMKKNGRVSGLRFCRTEQQEDGTWIVDEEQIVHLKADFIISAFGSMLNDPAVTKALDPIKLNRWGTPEVNSETMQTTEPWVFAGGDIAGFANTTVESVNDGKQASWHIHKYIQSLHGNTISAT-PRLPLFHCAIDTVDISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIVRGTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSYNQADWTELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRKATSIPFFAKLTPNVTNIVDIATAAYEGGADGVTATNTVSGLMALKADATPWPGIGRGARTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTVIEDYCLGLKALLYLKSIEELHDWDGQSPPTIRHQKGKPVPHVSELIGKSLPSFGPYLQTKTQALAKYKKDASGDVIMDTGAARVNIPKKPIPNVKDVIARALRHIGAYQELDNTEQVQALVDPEMCINCGKCYMTCNDSGYQAIKFDPETHLPVITDSCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPVNPVC 985
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Zebrafish
Match: dpydb (dihydropyrimidine dehydrogenase b [Source:NCBI gene;Acc:405829])

HSP 1 Score: 1204.5 bits (3115), Expect = 0.000e+0
Identity = 586/949 (61.75%), Postives = 729/949 (76.82%), Query Frame = 3 
Query:  381 RCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL--QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLK--SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELD-------KCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY*N*MC 3179
            RCLKCADAPCQKSCPT LDIKSFITSI+NKNYYGAAK I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQIR+P L   ++   S+  + I LIGCGPASISCA+FLARLGY  I IFEK  + GGLSTSEIP+FRLPY+VV FE+ LM DLGV + L K L +N      LK   Y  +F+G GLP A    IF  LT EQGFYTSK FLP+V+++SK GMC C  +LP+LHGNVIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT I  VPEEME AKEEKCEF+PF+SP+  E+ K   ++  + F +T + E+G   +D +QI+ LK DF+ISAFGS L D  + ++L P+++N++G PE +  T++T    VF GGD+AG A TTVE+VNDGKQA+W+IH Y+QS + N I  T P LPLF+ AID VD+S+E+CGIKFPNPFGLASAPPT SA+MIRR FE GWGFA+TKTF LDKDLVTNVSPRI+RG TSG ++GP QGSFLN+EL+SEK A YW K + EL+ DFP  ++IASI CS+N+ DW +L++M +E  A ALELNLSCPHGM ERG+GLACGQ P +V  IC+W++KA  IPFF KLTPN+TNI+DIA A+YEGGA GVTATNTVS LM +K +   WP +G   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D   GLKALL+++ IEEL DW+ QSP T +H KGKP+     +  K++P FG +L+ + + +     +              N+PKK I  V+++I ++L  IG ++ L+  EQV A++D +MCINCGKCYM CNDSGYQAIKFDP TH+P +T+ CTGC LC +VCPI+DCI MV +T  +   RG+  N +C
Sbjct:    1 RCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQIRNPELPTADNMPKSF-HTRIALIGCGPASISCASFLARLGYDNITIFEKQKYIGGLSTSEIPQFRLPYEVVQFEIDLMKDLGVKVVLEKGLGQNGLTLTSLKEEGYQVVFIGIGLPQANRDKIFEGLTTEQGFYTSKDFLPLVAKASKIGMCNCRSQLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMEAAKEEKCEFLPFLSPH--EVMKKNGRVSGLRFCRTEQQEDGTWIVDEEQIVHLKADFIISAFGSMLNDPAVTKALDPIKLNRWGTPEVNSETMQTTEPWVFAGGDIAGFANTTVESVNDGKQASWHIHKYIQSLHGNTISAT-PRLPLFHCAIDTVDISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIVRGTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSYNQADWTELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRKATSIPFFAKLTPNVTNIVDIATAAYEGGADGVTATNTVSGLMALKADATPWPGIGRGARTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTVIEDYCLGLKALLYLKSIEELHDWDGQSPPTIRHQKGKPVPHVSELIGKSLPSFGPYLQTKTQALAKYKKDASGDVIMDTGAARVNIPKKPIPNVKDVIARALRHIGAYQELDNTEQVQALVDPEMCINCGKCYMTCNDSGYQAIKFDPETHLPVITDSCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPVNPVC 945
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Zebrafish
Match: dpyda.3 (dihydropyrimidine dehydrogenase a, tandem duplicate 3 [Source:ZFIN;Acc:ZDB-GENE-131121-37])

HSP 1 Score: 871.692 bits (2251), Expect = 0.000e+0
Identity = 422/703 (60.03%), Postives = 545/703 (77.52%), Query Frame = 3 
Query: 1101 MCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVP-----------KKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            MC C   LP L G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT I  VPEEMELAKEEKCEF+PF+SP +V L     ++H M F +T + E+G+   D +QI+ LK DF+ISAFGS + D  ++E++ PVR+N++GLP+ D  +++T+   VF GGD+AG+A TTVEAVNDGKQA+W++H YLQS +   +    P LPLFY+ ID VD+S+E+CGI FPNPFGLASAPPT SA+MIRR FE GWGFA+TKTF+L+KDLVTNVSPRI+RG TSG L+GP QGSFLN+EL+SEK A YW + ++EL+ DFP+ ++I+SI CS+N+ DW +L++M EE GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV  PFF KLTPN+TNI+DIA+A+ EGGA GVTATNTVS LM +K +G  WP +G  +R+TYGG+SGNAIRPI++RAVSAIAK++P FPILATGGIDSAE+AL+FL+ GA  +Q+CSA+QNQDFT+I+D  TGLKALL+++ IEEL DW+ QSP T +H++GKP+        K +P FG +L+E+++ I N   +L     SN P           K    KV+++IGK+L  IG ++ LN++EQV A+ID +MCINCGKCYM CND+GYQAI FDP TH+P+V + CTGC LC +VCPI+DCI MV +T  +V  RG+
Sbjct:    1 MCGCVSALPDLCGTVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMELAKEEKCEFLPFLSPREVLLKG--GRVHGMEFCRTEQTESGQWVEDEEQIIRLKADFIISAFGSMMKDPAVMEAMAPVRLNRWGLPDLDLESMQTSEPWVFAGGDVAGLANTTVEAVNDGKQASWHMHKYLQSNFGLMVS-GPPRLPLFYSPIDTVDISVEMCGITFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFSLNKDLVTNVSPRIVRGSTSGPLFGPGQGSFLNIELISEKTAAYWCQSVRELKADFPDNIVISSIMCSYNKADWTELAKMAEESGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVHTPFFAKLTPNVTNIVDIAKAAQEGGADGVTATNTVSGLMGLKADGSPWPAIGRGRRSTYGGVSGNAIRPIALRAVSAIAKALPDFPILATGGIDSAESALQFLHAGATVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPPTVRHHRGKPVPLLEEFKGKCLPSFGPYLQEKKEVIANHKKKLKNY--SNNPVSLDKTRVYTLKAPAPKVKDMIGKALKHIGAYQELNIQEQVQALIDPEMCINCGKCYMTCNDAGYQAIVFDPDTHLPSVQDSCTGCTLCLSVCPIIDCIRMVDRTAPYVPKRGL 698
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Zebrafish
Match: dpyda.1 (dihydropyrimidine dehydrogenase a, tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-061013-727])

HSP 1 Score: 346.665 bits (888), Expect = 2.198e-111
Identity = 163/234 (69.66%), Postives = 192/234 (82.05%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL-QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLP 857
            MLS++LPDIE++L+LNP+   +A L+ +   K EK +WKRN +K C +C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT L+IK+FITSIANKNYYGAA+ I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFATD+F+QM +PQIR+P+L     +     S I LIGCGPASISCA+FLARLGY  I +FEK  F GGLS+SEIP+FRLP
Sbjct:    4 MLSKELPDIESILALNPRVQTHAALLSTRTKKMEKKQWKRNAEKGCESCVKLENNFDDIKHTTLSERGALREAVRCLKCADAPCQKSCPTNLNIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATDVFKQMGVPQIRNPDLPPPDQMPEIYHSKIALIGCGPASISCASFLARLGYDNISVFEKQRFIGGLSSSEIPQFRLP 237
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Xenopus
Match: rab25 (RAB25, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-494256])

HSP 1 Score: 1306.58 bits (3380), Expect = 0.000e+0
Identity = 643/1018 (63.16%), Postives = 793/1018 (77.90%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL-QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSN---------VPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            MLSRD  DIEN+L+LNP+T  +A L  +   K  K  WKRN D++CS CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT+IF+ M IPQIR+P+L     + +  ++ I LIG GPASISCA+FLARLGYS I +FEK  + GGLSTSEIP+FRLPY VV FE++LM DLGV +   K L  N M ++ L +  + AIF+G GLP  K  D+F  LT E GFYTSK FLP+V+++SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT +  VPEE+ELAKEEKCEF+PF+SP KV L     KI  M F +T ++++G    D DQ + LK + VISAFGS LTD  ++E++KP++ N++GLPE D +T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH ++QS +   I   KPELPLFYT ID VD+S+E+ GIKFPNPFGLASAPPT SA MIRR FEAGWGFA+TKTF+L+KD+VTNVSPRIIRG TSG +YGP QGSFLN+EL+SEK A YW + I EL+ DFP  +LIASI CS+N+DDW +L+ M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+T+++ IA A+ EGGA GVTATNTVS LM +K +   WP VG   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D  TGLKALL+++ I+EL DW+ QSP T +H KGKP+     I  + +P FG +L++R K I+ +N   D  C ++         VP K I  V+++IG++L  IG +  LN++EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+ TVT+ CTGC LC +VCPI+DCI MV +T  +V  RG+
Sbjct:    4 MLSRDPLDIENILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGPASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLGMNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSPLPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPFLSPRKVILKG--GKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIKFNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSI-TNKPELPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTNVSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDWTELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDELQDWDGQSPPTIRHQKGKPVPTIAEIKGEKLPSFGPYLEKR-KRILAENKINDLTCNTSPVTKEKTHFVPNKPIPSVKDVIGRALQYIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDSGYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGL 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Xenopus
Match: rab25 (RAB25, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-494256])

HSP 1 Score: 1293.87 bits (3347), Expect = 0.000e+0
Identity = 635/1009 (62.93%), Postives = 785/1009 (77.80%), Query Frame = 3 
Query:  186 ENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL-QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSN---------VPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
             N+L+LNP+T  +A L  +   K  K  WKRN D++CS CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT+IF+ M IPQIR+P+L     + +  ++ I LIG GPASISCA+FLARLGYS I +FEK  + GGLSTSEIP+FRLPY VV FE++LM DLGV +   K L  N M ++ L +  + AIF+G GLP  K  D+F  LT E GFYTSK FLP+V+++SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT +  VPEE+ELAKEEKCEF+PF+SP KV L     KI  M F +T ++++G    D DQ + LK + VISAFGS LTD  ++E++KP++ N++GLPE D +T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH ++QS +   I   KPELPLFYT ID VD+S+E+ GIKFPNPFGLASAPPT SA MIRR FEAGWGFA+TKTF+L+KD+VTNVSPRIIRG TSG +YGP QGSFLN+EL+SEK A YW + I EL+ DFP  +LIASI CS+N+DDW +L+ M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+T+++ IA A+ EGGA GVTATNTVS LM +K +   WP VG   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D  TGLKALL+++ I+EL DW+ QSP T +H KGKP+     I  + +P FG +L++R K I+ +N   D  C ++         VP K I  V+++IG++L  IG +  LN++EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+ TVT+ CTGC LC +VCPI+DCI MV +T  +V  RG+
Sbjct:    3 RNILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGPASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLGMNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSPLPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPFLSPRKVILKG--GKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIKFNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSI-TNKPELPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTNVSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDWTELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDELQDWDGQSPPTIRHQKGKPVPTIAEIKGEKLPSFGPYLEKR-KRILAENKINDLTCNTSPVTKEKTHFVPNKPIPSVKDVIGRALQYIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDSGYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGL 1007
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Xenopus
Match: rab25 (RAB25, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-494256])

HSP 1 Score: 1291.56 bits (3341), Expect = 0.000e+0
Identity = 635/1008 (63.00%), Postives = 785/1008 (77.88%), Query Frame = 3 
Query:  189 NLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL-QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSN---------VPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            N+L+LNP+T  +A L  +   K  K  WKRN D++CS CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT+IF+ M IPQIR+P+L     + +  ++ I LIG GPASISCA+FLARLGYS I +FEK  + GGLSTSEIP+FRLPY VV FE++LM DLGV +   K L  N M ++ L +  + AIF+G GLP  K  D+F  LT E GFYTSK FLP+V+++SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT +  VPEE+ELAKEEKCEF+PF+SP KV L     KI  M F +T ++++G    D DQ + LK + VISAFGS LTD  ++E++KP++ N++GLPE D +T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH ++QS +   I   KPELPLFYT ID VD+S+E+ GIKFPNPFGLASAPPT SA MIRR FEAGWGFA+TKTF+L+KD+VTNVSPRIIRG TSG +YGP QGSFLN+EL+SEK A YW + I EL+ DFP  +LIASI CS+N+DDW +L+ M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+T+++ IA A+ EGGA GVTATNTVS LM +K +   WP VG   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D  TGLKALL+++ I+EL DW+ QSP T +H KGKP+     I  + +P FG +L++R K I+ +N   D  C ++         VP K I  V+++IG++L  IG +  LN++EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+ TVT+ CTGC LC +VCPI+DCI MV +T  +V  RG+
Sbjct:   17 NILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGPASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLGMNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSPLPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPFLSPRKVILKG--GKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIKFNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSI-TNKPELPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTNVSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDWTELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDELQDWDGQSPPTIRHQKGKPVPTIAEIKGEKLPSFGPYLEKR-KRILAENKINDLTCNTSPVTKEKTHFVPNKPIPSVKDVIGRALQYIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDSGYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGL 1020
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Xenopus
Match: rab25 (RAB25, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-494256])

HSP 1 Score: 1278.85 bits (3308), Expect = 0.000e+0
Identity = 630/1000 (63.00%), Postives = 777/1000 (77.70%), Query Frame = 3 
Query:  186 ENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL-QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +N+L+LNP+T  +A L  +   K  K  WKRN D++CS CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT+IF+ M IPQIR+P+L     + +  ++ I LIG GPASISCA+FLARLGYS I +FEK  + GGLSTSEIP+FRLPY VV FE++LM DLGV +   K L  N M ++ L +  + AIF+G GLP  K  D+F  LT E GFYTSK FLP+V+++SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT +  VPEE+ELAKEEKCEF+PF+SP KV L     KI  M F +T ++++G    D DQ + LK + VISAFGS LTD  ++E++KP++ N++GLPE D +T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH ++QS +   I   KPELPLFYT ID VD+S+E+ GIKFPNPFGLASAPPT SA MIRR FEAGWGFA+TKTF+L+KD+VTNVSPRIIRG TSG +YGP QGSFLN+EL+SEK A YW + I EL+ DFP  +LIASI CS+N+DDW +L+ M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+T+++ IA A+ EGGA GVTATNTVS LM +K +   WP VG   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D  TGLKALL+++ I+EL DW+ QSP T +H KGKP+     I  + +P FG +L++R K I+ +N   D  C ++   K       +   SL  IG +  LN++EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+ TVT+ CTGC LC +VCPI+DCI MV +T  +V  RG+
Sbjct:   15 QNILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGPASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLGMNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSPLPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPFLSPRKVILKG--GKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIKFNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSI-TNKPELPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTNVSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDWTELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDELQDWDGQSPPTIRHQKGKPVPTIAEIKGEKLPSFGPYLEKR-KRILAENKINDLTCNTSPVTKEKTHFVPLPFDSLQYIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDSGYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGL 1010
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Xenopus
Match: rab25 (RAB25, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-494256])

HSP 1 Score: 1256.12 bits (3249), Expect = 0.000e+0
Identity = 623/995 (62.61%), Postives = 762/995 (76.58%), Query Frame = 3 
Query:  186 ENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL-QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPIISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +N+L+LNP+T  +A L  +   K  K  WKRN D++CS CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT+IF+ M IPQIR+P+L     + +  ++ I LIG GPASISCA+FLARLGYS I +FEK  + GGLSTSEIP+FRLPY VV FE++LM DLGV +   K L  N M ++ L +  + AIF+G GLP  K  D+F  LT E GFYTSK FLP+V+++SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGFT +  VPEE+ELAKEEKCEF+PF+SP KV L     KI  M F +T ++++G    D DQ + LK + VISAFGS LTD  ++E++KP++ N++GLPE D +T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH ++QS +   I   KPELPLFYT ID VD+S+E+ GIKFPNPFGLASAPPT SA MIRR FEAGWGFA+TKTF+L+KD+VTNVSPRIIRG TSG +YGP QGSFLN+EL+SEK A YW + I EL+ DFP  +LIASI CS+N+DDW +L+ M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+T+++ IA A+ EGGA GVTATNTVS LM +K +   WP VG   RTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I+D  TGLKALL+++ I+EL DW+ QSP T +H KGKP      VP   +   E                 S +P  S+Q            IG +  LN++EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+ TVT+ CTGC LC +VCPI+DCI MV +T  +V  RG+
Sbjct:   15 QNILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGPASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLGMNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSPLPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPFLSPRKVILKG--GKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIKFNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSI-TNKPELPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTNVSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDWTELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDELQDWDGQSPPTIRHQKGKP------VPTIAEIKGEWG---------------SPLPFDSLQ-----------YIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDSGYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGL 974
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Mouse
Match: Dpyd (dihydropyrimidine dehydrogenase [Source:MGI Symbol;Acc:MGI:2139667])

HSP 1 Score: 1282.32 bits (3317), Expect = 0.000e+0
Identity = 630/1018 (61.89%), Postives = 787/1018 (77.31%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLKS-YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDI----INQNNELDKCCPSNV----PKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LSRD PDIE++L+LNP+   +A L  +   K +K  WKRN DKNC TCE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNL+  EEGPINIGGLQQFAT++F+ M IPQIR+P+L    H   +Y  + I L G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K LS + MT+  L ++ Y A F+G GLP+ K   IF  LTQ QGFYTSK FLP+V++SSK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA RV+I+FRKGF  I  VPEEMELAKEEKCEF+PF+SP KV +     KI +M F +T ++E G    D +Q + LK D VISAFGS L D ++ E+L P++ N++GLPE +  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH ++Q++Y   +  ++P +PLFYT +D VD+S+E+ G++FPNPFGLASA P  S  MIRR FEAGWGFA+TKTF+LDKD+VTNVSPRIIRG TSG LYGP Q SFLN+EL+SEK A YW   + EL+ DFP+ +LIASI CS+N+ DW++LS+M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV++PFF KLTPN+T+I+ IARA+ EGGA GVTATNTVS LM +K +G  WP VG  +RTTYGG+SG AIRPI++RAV+AIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSAIQNQDFT+I+D  TGLKALL+++ IEEL+DW+ QSP    H KGKP+     +  + +P FG +L++R+K I    I Q ++   C P        +K I  ++++IGKSL  +G F  +++ EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PTV++ CTGC LC +VCPI+DCI MV +   +   RG+
Sbjct:    4 VLSRDAPDIESILALNPRVQAHATLRSTAAKKLDKKHWKRNTDKNCFTCEKLESNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHAAEEGPINIGGLQQFATEVFKAMNIPQIRNPSLPPPEHMPEAY-SAKIALFGAGPASISCASFLARLGYSNITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSTDEMTLSSLKENGYRAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKSSKTGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGALRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKD--GKIVAMQFVRTEQDETGNWVEDEEQTVRLKADVVISAFGSVLEDPKVKEALSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKHIQAQYGTSVP-SQPTMPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKSDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGIGRRTTYGGVSGTAIRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELADWDGQSPPIISHQKGKPVPRVAELMGQKLPSFGPYLEQRKKIIAASKIRQKDQNTACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGEMSIMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYQPKRGL 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Mouse
Match: Dpyd (dihydropyrimidine dehydrogenase [Source:MGI Symbol;Acc:MGI:2139667])

HSP 1 Score: 96.2857 bits (238), Expect = 1.752e-23
Identity = 44/75 (58.67%), Postives = 55/75 (73.33%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANR 383
            +LSRD PDIE++L+LNP+   +A L  +   K +K  WKRN DKNC TCE LE NF+D+K TTL ERGAL+EA R
Sbjct:    4 VLSRDAPDIESILALNPRVQAHATLRSTAAKKLDKKHWKRNTDKNCFTCEKLESNFDDIKHTTLGERGALREAVR 78
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Mouse
Match: Dhodh (dihydroorotate dehydrogenase [Source:MGI Symbol;Acc:MGI:1928378])

HSP 1 Score: 64.6994 bits (156), Expect = 2.768e-10
Identity = 84/332 (25.30%), Postives = 145/332 (43.67%), Query Frame = 3 
Query: 1746 LSIEICGIKFPNPFGLASA-PPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVG-----AQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIP----FFVKLTPNIT--NILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD 2693
            L + + G KF NP G+A+     G A  +   ++ G+GF    + T  +    N  PR+ R      +   YG N      VE        + L+  Q+ +       L   I    N+      +  VE V      A  L +N+S P+    R L     ++ R++ ++ Q  + A+K P      VK+ P++T  +  DIA  + E G  G+  TNT  S   + + G          R+  GG+SG  +R +S + +  +     G  PI+  GG+ S ++AL+ +  GA+ VQ+ +A+      ++  +   L+ALL  +G   ++D
Sbjct:   78 LEVRVLGHKFRNPVGIAAGFDKHGEA--VDGLYKLGFGFVEVGSVT-PQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVE--------HRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSL-QGKTELRRLLSKVLQE-RDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVS-RPVGLQGAL--------RSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTD 387
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. UniProt/SwissProt
Match: sp|Q12882|DPYD_HUMAN (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX=9606 GN=DPYD PE=1 SV=2)

HSP 1 Score: 1289.25 bits (3335), Expect = 0.000e+0
Identity = 639/1020 (62.65%), Postives = 793/1020 (77.75%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQN-HFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLL-KSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQN-----------NELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LS+D  DIE++L+LNP+T  +A L  +   K +K  WKRN DKNC  CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEGPINIGGLQQFAT++F+ M IPQIR+P+L     ++    + I L G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K LS N MT+  L  K Y A F+G GLP+     IF  LTQ+QGFYTSK FLP+V++ SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+I+FRKGF  I  VPEEMELAKEEKCEF+PF+SP KV +     +I +M F +T ++E G+   D DQ++ LK D VISAFGS L+D ++ E+L P++ N++GLPE D  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH Y+QS+Y   +   KPELPLFYT ID VD+S+E+ G+KF NPFGLASA P  S SMIRR FEAGWGFA+TKTF+LDKD+VTNVSPRIIRG TSG +YGP Q SFLN+EL+SEK A YW + + EL+ DFP+ ++IASI CS+N++DW +L++  E+ GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV+IPFF KLTPN+T+I+ IARA+ EGGA+GVTATNTVS LM +K +G  WP VG  KRTTYGG+SG AIRPI++RAV++IA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSAIQNQDFT+I+D  TGLKALL+++ IEEL DW+ QSP T  H KGKP+     +  K +P FG +L++R+K II +N           + L + C   +PK+ I  ++++IGK+L  +G F  L+  EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PT+T+ CTGC LC +VCPIVDCI MV +T  +   RGV
Sbjct:    4 VLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKG--GRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSA-KPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKK-IIAENKIRLKEQNVAFSPLKRNC--FIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGV 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. UniProt/SwissProt
Match: sp|O89000|DPYD_RAT (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Rattus norvegicus OX=10116 GN=Dpyd PE=2 SV=1)

HSP 1 Score: 1287.71 bits (3331), Expect = 0.000e+0
Identity = 633/1018 (62.18%), Postives = 784/1018 (77.01%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLK--SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDI----INQNNELDKCCPSNV----PKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LSRD PDIE++L+LNP+   +A L  +   K +K  WKRN DKNC  CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNL+ TEEGPINIGGLQQFAT++F+ M IPQIR P L    H   +Y  + I L G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K +S +      LK   Y A F+G GLP+ K   IF  LTQ QGFYTSK FLP+V++ SKPGMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+I+FRKGF  I  VPEEMELAKEEKCEF+PF+SP KV +     KI  M F +T ++E G    D +QI+ LK D VIS FGS L D ++IE+L P++ N++GLPE +  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH Y+Q++Y   +  ++P LPLFYT +D VD+S+E+ G++FPNPFGLASA P  S  MIRR FEAGWGFA+TKTF+LDKD+VTNVSPRIIRG TSG LYGP Q SFLN+EL+SEK A YW   + EL+ DFP+ +LIASI CS+N++DW++LS+M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W++++V++PFF KLTPN+T+I+ IARA+ EGGA GVTATNTVS LM +K +G  WP VG+ KRTTYGG+SG  IRPI++RAV+AIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSAIQNQDFT+I+D  TGLKALL+++ IEELSDW+ QSP T  H KGKP+     +  + +P FG +L+ R+K +    I +N++   C P        +K I  ++++IGKSL  +G F  LN+ EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PTV++ CTGC LC +VCPI+DCI MV +   +   RG+
Sbjct:    4 VLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRNTDKNCFICEKLENNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHATEEGPINIGGLQQFATEVFKAMNIPQIRSPLLPPPEHMPEAY-SAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSISTDEMTLSTLKENGYKAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKGSKPGMCACHSPLPSVRGAVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFANIRAVPEEMELAKEEKCEFLPFLSPRKVIVKD--GKIVGMQFVRTEQDETGNWVEDEEQIVRLKADVVISPFGSVLDDPKVIEALSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHEYIQAQYGALVP-SQPTLPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKNDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGSPWPSVGSGKRTTYGGVSGTTIRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELSDWDGQSPPTMSHQKGKPVPHIAELMGQKLPSFGPYLERRKKILAASKIRENDQNRACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGELNIMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYEPKRGL 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. UniProt/SwissProt
Match: sp|Q28943|DPYD_PIG (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Sus scrofa OX=9823 GN=DPYD PE=1 SV=1)

HSP 1 Score: 1285.78 bits (3326), Expect = 0.000e+0
Identity = 630/1018 (61.89%), Postives = 788/1018 (77.41%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL--QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKS--YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPS--------NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LS+D+ DIE++L+LNP+T  +A L  +   K +K  WKRN DKNC  CE LE NF D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSI+NKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNLY TEEG INIGGLQQFA+++F+ M IPQIR+P L  Q     +Y  + I L+G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K LS+N    + LK   Y A F+G GLP+ K  DIF  LTQ+QGFYTSK FLP+V++SSK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGF  I  VPEE+ELAKEEKCEF+PF+SP KV +     +I ++ F +T ++E G+   D DQI+ LK D VISAFGS L D ++ E+L P++ N++ LPE D  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH Y+Q++Y   +   KPELPLFYT +D VD+S+E+ G+KF NPFGLASA PT S+SMIRR FEAGWGFA+TKTF+LDKD+VTNVSPRI+RG TSG +YGP Q SFLN+EL+SEK A YW + + EL+ DFP+ ++IASI CS+N++DW++LS+  E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV+IPFF KLTPN+T+I+ IARA+ EGGA GVTATNTVS LM +K +G  WP VG  KRTTYGG+SG AIRPI++RAV+ IA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFT+I D  TGLKALL+++ IEEL  W+ QSP T  H KGKP+     +  K +P FG +L++R+K I  +   L +   +         +PKK I  ++++IGK+L  +G F  L+  EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PTVT+ CTGC LC +VCPI+DCI MV +T  +   RG+
Sbjct:    4 VLSKDVADIESILALNPRTQSHAALHSTLAKKLDKKHWKRNPDKNCFHCEKLENNFGDIKHTTLGERGALREAMRCLKCADAPCQKSCPTHLDIKSFITSISNKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGSINIGGLQQFASEVFKAMNIPQIRNPCLPSQEKMPEAY-SAKIALLGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSENEITLNTLKEEGYKAAFIGIGLPEPKTDDIFQGLTQDQGFYTSKDFLPLVAKSSKAGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGARRVFLVFRKGFVNIRAVPEEVELAKEEKCEFLPFLSPRKVIVKG--GRIVAVQFVRTEQDETGKWNEDEDQIVHLKADVVISAFGSVLRDPKVKEALSPIKFNRWDLPEVDPETMQTSEPWVFAGGDIVGMANTTVESVNDGKQASWYIHKYIQAQYGASVSA-KPELPLFYTPVDLVDISVEMAGLKFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIVRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWMELSRKAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGAGKRTTYGGVSGTAIRPIALRAVTTIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIQDYCTGLKALLYLKSIEELQGWDGQSPGTESHQKGKPVPRIAELMGKKLPNFGPYLEQRKKIIAEEKMRLKEQNAAFPPLERKPFIPKKPIPAIKDVIGKALQYLGTFGELSNIEQVVAVIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVTDTCTGCTLCLSVCPIIDCIRMVSRTTPYEPKRGL 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. UniProt/SwissProt
Match: sp|Q5R895|DPYD_PONAB (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Pongo abelii OX=9601 GN=DPYD PE=2 SV=1)

HSP 1 Score: 1283.86 bits (3321), Expect = 0.000e+0
Identity = 633/1017 (62.24%), Postives = 787/1017 (77.38%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQN-HFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLL-KSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDK----CCPSN----VPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LS+D  DIE++L+LNP+T  +A L  +   K +K  WKRN DKNC  CE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPT DLCVG CNLY TEEGPINIGGLQQFAT++F+ M IPQIR+P L     ++    + I L G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K LS N MT+  L  K Y A F+G GLP+     IF  LTQ+QGFYTSK FLP+V++ SK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA+RV+I+FRKGF  I  VPEEMELAKEEKCEF+PF+SP KV +     +I +M F +T ++E G+   D DQ++ LK D VISAFGS L+D ++ E++ P++ N++GLPE D  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH Y+QS+Y   +   KPELPLFYTAID VD+S+E+ G+KF NPFGLASA P  S SMIRR FEAGWGFA+TKTF+LDKD+VTNVSPRI+RG TSG +YGP Q SFLN+EL+SEK A YW + + EL+ DFP+ ++IASI CS+N++DW +L++  E+ GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV+IPFF KLTPN+T+I+ IARA+ EGGA+GVTATNTVS LM +K +G  WP VG  KRTTYGG+SG AIRPI++RAV++ A+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSAIQNQDFT+I+D  TGLKALL+++ IEEL DW+ QSP T  H KGKP+     +  K +P FG +L++R+K I      L +      P      +PK+ +  ++++IGK+L  +G F  L+  EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PT+T+ CTGC LC +VCPIVDCI MV +T  +   RGV
Sbjct:    4 VLSKDSADIESILALNPRTQTHATLRSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTPDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPFLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKG--GRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEAMSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYIQSQYGASVSA-KPELPLFYTAIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIVRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSTARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNIASSPHKRNCFIPKRPVPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGV 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. UniProt/SwissProt
Match: sp|Q8CHR6|DPYD_MOUSE (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Mus musculus OX=10090 GN=Dpyd PE=1 SV=1)

HSP 1 Score: 1282.32 bits (3317), Expect = 0.000e+0
Identity = 630/1018 (61.89%), Postives = 787/1018 (77.31%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLKS-YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDI----INQNNELDKCCPSNV----PKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LSRD PDIE++L+LNP+   +A L  +   K +K  WKRN DKNC TCE LE NF+D+K TTL ERGAL+EA RCLKCADAPCQKSCPT LDIKSFITSIANKNYYGAAK+IFSDNPLGLTCGMVCPTSDLCVG CNL+  EEGPINIGGLQQFAT++F+ M IPQIR+P+L    H   +Y  + I L G GPASISCA+FLARLGYS I IFEK ++ GGLSTSEIP+FRLPY VV+FE++LM DLGV +   K LS + MT+  L ++ Y A F+G GLP+ K   IF  LTQ QGFYTSK FLP+V++SSK GMCAC   LP + G VIVLGAGDTAFDCAT ALRCGA RV+I+FRKGF  I  VPEEMELAKEEKCEF+PF+SP KV +     KI +M F +T ++E G    D +Q + LK D VISAFGS L D ++ E+L P++ N++GLPE +  T++T+   VF GGD+ G+A TTVE+VNDGKQA+WYIH ++Q++Y   +  ++P +PLFYT +D VD+S+E+ G++FPNPFGLASA P  S  MIRR FEAGWGFA+TKTF+LDKD+VTNVSPRIIRG TSG LYGP Q SFLN+EL+SEK A YW   + EL+ DFP+ +LIASI CS+N+ DW++LS+M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AV++PFF KLTPN+T+I+ IARA+ EGGA GVTATNTVS LM +K +G  WP VG  +RTTYGG+SG AIRPI++RAV+AIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSAIQNQDFT+I+D  TGLKALL+++ IEEL+DW+ QSP    H KGKP+     +  + +P FG +L++R+K I    I Q ++   C P        +K I  ++++IGKSL  +G F  +++ EQVVA+IDE+MCINCGKCYM CNDSGYQAI+FDP TH+PTV++ CTGC LC +VCPI+DCI MV +   +   RG+
Sbjct:    4 VLSRDAPDIESILALNPRVQAHATLRSTAAKKLDKKHWKRNTDKNCFTCEKLESNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHAAEEGPINIGGLQQFATEVFKAMNIPQIRNPSLPPPEHMPEAY-SAKIALFGAGPASISCASFLARLGYSNITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSTDEMTLSSLKENGYRAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKSSKTGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGALRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKD--GKIVAMQFVRTEQDETGNWVEDEEQTVRLKADVVISAFGSVLEDPKVKEALSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKHIQAQYGTSVP-SQPTMPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKSDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGIGRRTTYGGVSGTAIRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELADWDGQSPPIISHQKGKPVPRVAELMGQKLPSFGPYLEQRKKIIAASKIRQKDQNTACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGEMSIMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYQPKRGL 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. TrEMBL
Match: A0A088AHJ1 (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Apis mellifera OX=7460 GN=LOC410207 PE=3 SV=1)

HSP 1 Score: 1329.69 bits (3440), Expect = 0.000e+0
Identity = 661/1018 (64.93%), Postives = 808/1018 (79.37%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSK-NMTVKDLLKS-YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSY-KLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTK-PELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPIISR----KNVPFFGKFLKEREKDIIN---QNNELD------KCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +LS+D+PDIENLL LNPK   +A +VPS  TK  K KWKRN ++NCS C  L  NF+D+K TTLSERGALKEA RCLKCADAPCQKSCPTQLDIKSFITSI+NKNYYGAAK I SDNPLGLTCGMVCPTSDLCVG CNL+ +EEGPINIGGLQQFATDIF+QM I Q R P  QN    S+ ++ I L+GCGPAS+SCATFLARLGY+ I IFEK ++ GGLS+SEIP++RLPY +V+FE+ L+ DLGV + L K LSK N+T++ L  S Y AIFLG GLPDAK I IF++LT+E GF+TSK FLP V++ SKPGMCAC   +LP LHG V+VLGAGDTAFDCAT ALRCGAK++Y++FRKGFT I  VPEE +LAKEEKCEFIPF SP +V +     KI ++ F++T ENEN E   D +QI  LK DFVISAFGS L +Q++I+++ P+++NK+ LPE D  T+ T++  VFCGGDLAG+A TTVE+VNDGK AAWYIH ++Q+ YN  ++V K P+LP F+T ID VDLSIEICG+KF NPFGLASAPPT S++MIRR FEAGWGF VTKTF+LDKDLVTNVSPRII+G TS   YGP QGSFLN+EL+SEK   YW   I+EL+KDFP ++LIASI CS+N  DW +LSQ  E  GA ALELNLSCPHGM E G+GLACGQ P +V  I +WI++AVKIPFFVKLTPNIT+I+ IA+A+YEG A+GV+A NTV SLM +  +   WP VG  K TTYGGMSGNA RP ++RAVSAI+K++PGFPIL  GGI+SA+ AL+FL+CGA+ +Q+CSA+QNQDFTLIDD ITGLKALL+++ +++L +W+ QSP T KH KGKP++ +    KN+P+FG++ K RE  I      +N LD      +  P  +   +I  ++++IGK+LN IG +K LN +EQV+A+ID+DMCINCGKCY+AC DSGYQAIKFD  THIPTVT+DCTGC LC +VCPI+DCITMVPK I HV+NRGV
Sbjct:    6 ILSKDVPDIENLLHLNPKIKPFANVVPSAITKENKRKWKRNINENCSKCPPLTKNFDDIKHTTLSERGALKEAARCLKCADAPCQKSCPTQLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLHASEEGPINIGGLQQFATDIFKQMNISQTRIPG-QN---VSHADTKIALLGCGPASLSCATFLARLGYNNITIFEKQNYIGGLSSSEIPQYRLPYDIVNFEIDLVKDLGVKIELGKALSKDNLTIESLQNSGYKAIFLGIGLPDAKAIPIFSNLTEEMGFFTSKSFLPKVAKGSKPGMCACKRNELPSLHGKVVVLGAGDTAFDCATSALRCGAKKIYVVFRKGFTNIRAVPEEFDLAKEEKCEFIPFQSPKQVIVR--NGKIIAIEFYRTEENENDEWIEDKEQICRLKADFVISAFGSGLQNQDVIQAMVPIKMNKWNLPEVDSQTMSTSIPGVFCGGDLAGIAHTTVESVNDGKTAAWYIHKFIQNSYN--LEVPKIPQLPKFHTPIDDVDLSIEICGLKFENPFGLASAPPTTSSTMIRRAFEAGWGFVVTKTFSLDKDLVTNVSPRIIKGTTSRHHYGPEQGSFLNIELISEKSEAYWCNSIRELKKDFPTKILIASIMCSYNRADWTELSQKAERAGADALELNLSCPHGMGESGMGLACGQDPVLVRNISRWIREAVKIPFFVKLTPNITDIVSIAKAAYEGHANGVSAINTVQSLMGLHADATPWPAVGIKKATTYGGMSGNATRPQALRAVSAISKALPGFPILGIGGIESADVALQFLHCGASVLQVCSAVQNQDFTLIDDYITGLKALLYLKNLKQLKNWDGQSPPTFKHQKGKPVVLQHALGKNIPYFGEYQKLREAKIAEIKAISNPLDNLVETTRSSPETI--TAIPSIKDVIGKALNYIGTYKDLNNKEQVIALIDDDMCINCGKCYIACADSGYQAIKFDSETHIPTVTDDCTGCTLCLSVCPIIDCITMVPKRIPHVINRGV 1013
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. TrEMBL
Match: W5MNR9 (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Lepisosteus oculatus OX=7918 PE=3 SV=1)

HSP 1 Score: 1328.54 bits (3437), Expect = 0.000e+0
Identity = 651/1018 (63.95%), Postives = 789/1018 (77.50%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKS--YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPIIS-----RKNVPFFGKFLKEREKDIINQNNELDKCCPSNV----------PKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            MLSRDL DIEN+L+LNP+   +A L  +  TK EK  WKRN DKNCS+CE LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LD+KSFITSIANKNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT+IF  M IPQIR+PNL +    S+  + I LIGCGPASISCA+FL RLGY  I IFEK  + GGLSTSEIP+FRLPY VV FE++LM +LGV +   K L  +      LK   Y A+F+G GLP+     IF  LT E+GFYTSK FLP+V+++SKPGMC+C  +LP LHG VIVLGAGDTAFDCAT ALRCGA+RV+++FRKGF  I  VPEEMELAKEEKCEF+PF+SP +V   K   +I SM   +T ENE G+   D  QI+ LKT+F+ISAFGS L D+++ E++ P++ N++GLPE D  T++T+   VF GGD+AG+A TTVE+VNDGKQA+WYIH Y+QS +   +D  KP+LPLFYT ID VD+S+E+ G+KF NPFGLASAPPT S +MIRR FE GW FA+TKTF+LDKDLVTNVSPRI+RG TSG ++GP QGSFLN+EL+SEK A YW + I EL+ DFP  +LIASI CS+N+ DW++LS+M E   A ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+TNI+DIA A++EGGA GVTATNTVS LM ++ +G  WP VG  KRTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE  L+FL  GA+ +Q+CSA+QNQDFTLI+D  TGLKALL+++ IEEL DW+ QSP T  H KGKPI+       K +P FG +L+ER+  +  Q  ++     S            PKK I  V ++I ++L  IG F  LN++EQVVA+IDE+MCINCGKCYM CNDSGYQAIKFDP TH+PTVT+ CTGC LC +VCPI+DCI MV +T  HV  RG+
Sbjct:    4 MLSRDLRDIENILTLNPRVKTHASLCSTATTKREKKHWKRNADKNCSSCEKLENNFDDIKHTTLSERGALREAMRCLKCADAPCQKSCPTNLDVKSFITSIANKNYYGAAKTIFSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEIFSTMGIPQIRNPNLSDKMHESFH-TKIALIGCGPASISCASFLGRLGYDDITIFEKQKYVGGLSTSEIPQFRLPYNVVQFEIELMKNLGVKVVCEKGLGYDQMTLSSLKEEGYEAVFIGMGLPEPNRHQIFEGLTMEEGFYTSKDFLPLVAKASKPGMCSCRSQLPVLHGTVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFKNIRAVPEEMELAKEEKCEFLPFLSPRRV--IKKGGQIVSMELCRTEENEAGDWIEDESQIVHLKTNFIISAFGSMLNDRKVKEAMTPIKFNRWGLPELDPETMQTSEPWVFAGGDIAGLANTTVESVNDGKQASWYIHKYVQSLHGRSVDC-KPQLPLFYTPIDLVDISVEMAGLKFLNPFGLASAPPTTSTAMIRRAFEEGWAFALTKTFSLDKDLVTNVSPRIVRGTTSGHVFGPGQGSFLNIELISEKTAAYWCQSITELKTDFPQHILIASIMCSYNKSDWMELSKMAEASEADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTNIVDIAMAAHEGGADGVTATNTVSGLMGLRADGTPWPAVGGGKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAEAGLQFLQAGASVLQVCSAVQNQDFTLIEDYCTGLKALLYLESIEELKDWDGQSPPTQCHQKGKPILKVSELVGKKLPCFGPYLEERKMMLAEQKLKMKMASESTAQQSNPKQPYTPKKPIPAVRDVIARALKHIGTFGELNIKEQVVALIDEEMCINCGKCYMTCNDSGYQAIKFDPETHLPTVTDSCTGCTLCLSVCPIIDCIRMVTRTTPHVPKRGL 1017
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. TrEMBL
Match: A0A2A3E9Z3 (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Apis cerana cerana OX=94128 GN=APICC_00420 PE=3 SV=1)

HSP 1 Score: 1325.07 bits (3428), Expect = 0.000e+0
Identity = 657/1017 (64.60%), Postives = 807/1017 (79.35%), Query Frame = 3 
Query:  153 LLMLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSK-NMTVKDLLKS-YSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSY-KLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTK-PELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPIISR----KNVPFFGKFLKERE------KDIINQNNELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            + +LS+D+PDIENLL LNPK   +A +VPS  TK  K KWKRN ++NCS C  L  NF+D+K TTLSERGALKEA RCLKCADAPCQKSCPTQLDIKSFITSI+NKNYYGAAK I SDNPLGLTCGMVCPTSDLCVG CNL+ +EEGPINIGGLQQFATDIF+QM I Q R P  QN    S+ ++ I L+GCGPAS+SCATFLARLGY+ I IFEK ++ GGLS+SEIP++RLPY +V+FE+ L+ DLGV + L K LSK N+T++ L  S Y AIFLG GLP+AK I IF++LT+E GF+TSK FLP V++ SKPGMCAC   +LP LHG V+VLGAGDTAFDCAT ALRCGAK++Y++FRKGFT I  VPEE +LAKEEKCEFIPF SP +V +     KI ++ F++T ENEN E   D +QI  LK DFVISAFGS L +QE+I+++ P+++NK+ LPE D  T+ T++  +FCGGDLAG+A TTVE+VNDGK AAWYIH ++Q+ YN  ++V K P+LP F+T ID +DLSIEICG+KF NPFGLASAPPT S++MIRR FEAGWGF VTKTF+LDKDLVTNVSPRII+G TS   YGP QGSFLN+EL+SEK   YW   I EL+KDFP ++LIASI CS+N  DW +LSQ  E  GA ALELNLSCPHGM E G+GLACGQ P +V  I +WI++AVKIPFFVKLTPNIT+I+ IA+A+YEG A+GV+A NTV SLM +  +   WP VG  K TTYGGMSGNA RP ++RAVSAI+K++PGFPIL  GGIDSA+ AL+FL+CGA+ +Q+CSA+QNQDFTLIDD  TGLKALL+++ ++++ +W+ QSP T KH KGKP++ +    KN+P+FG++ K RE      K I N  ++L     S  P  +I  ++++IGK+LN IG +K LN +EQV+A+ID+DMCINCGKCY+AC DSGYQAIKFD  THIPTVT+DCTGC LC +VCPI+DCITM+PK I H++NRGV
Sbjct:    4 ITILSKDVPDIENLLHLNPKIKPFANVVPSAITKENKRKWKRNINENCSKCPPLIKNFDDIKRTTLSERGALKEAARCLKCADAPCQKSCPTQLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLHASEEGPINIGGLQQFATDIFKQMNISQTRIPG-QN---VSHADTKIALLGCGPASLSCATFLARLGYNNITIFEKQNYIGGLSSSEIPQYRLPYDIVNFEIDLVKDLGVKIELGKELSKDNLTIEGLQNSGYKAIFLGIGLPEAKAIPIFSNLTEEMGFFTSKSFLPKVAKGSKPGMCACKRNELPSLHGKVVVLGAGDTAFDCATSALRCGAKKIYVVFRKGFTNIRAVPEEFDLAKEEKCEFIPFQSPKQVIVR--NGKIIAIEFYRTEENENDEWIEDKEQICRLKVDFVISAFGSGLQNQEVIQAMVPIKMNKWNLPEVDSQTMSTSIPGIFCGGDLAGIAHTTVESVNDGKTAAWYIHKFIQNSYN--LEVPKIPQLPKFHTPIDDIDLSIEICGLKFENPFGLASAPPTTSSTMIRRAFEAGWGFVVTKTFSLDKDLVTNVSPRIIKGTTSRHHYGPEQGSFLNIELISEKSEAYWCNSIIELKKDFPTKILIASIMCSYNRADWTELSQKAERAGADALELNLSCPHGMGESGMGLACGQDPVLVRNISRWIREAVKIPFFVKLTPNITDIVSIAKAAYEGHANGVSAINTVQSLMGLHADATPWPAVGIKKATTYGGMSGNATRPQALRAVSAISKALPGFPILGIGGIDSADVALQFLHCGASLLQVCSAVQNQDFTLIDDYTTGLKALLYLKNLKQVKNWDGQSPPTFKHQKGKPVVLQHALGKNIPYFGEYQKLREAKIAEIKAISNPLDKLKITRSSPEPITAIPSIKDVIGKALNYIGTYKDLNNKEQVIALIDDDMCINCGKCYIACADSGYQAIKFDSETHIPTVTDDCTGCTLCLSVCPIIDCITMIPKRIPHIINRGV 1012
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. TrEMBL
Match: A0A3B1J9M6 (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Astyanax mexicanus OX=7994 PE=3 SV=1)

HSP 1 Score: 1322.76 bits (3422), Expect = 0.000e+0
Identity = 642/1019 (63.00%), Postives = 801/1019 (78.61%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNEL----DKCCPS-----NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            MLS+DLPDIE++L+LNP+   +A L  +   K+EK  WKRN +K C +C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+ I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQ+R+P+L        SY  S I LIGCGPASISCATFLARLGYS I IFEK  + GGLS+SEIP+FRLPY+VV FEL LM DLGV +   K L +N MT+  L +  Y A+F+G GLP A    IF  L+ EQGFYTSK FLP+V+++SKPGMCAC + LP+LHG+VIVLGAGDTAFDCAT ALRCGA+RVY++FR+GFT I  VPEEMELAKEEKCEF+PF+SP +V L     ++H M F +T + E G+   D +QI  LK DF+ISAFGS L+D ++ E++ P+R+N++GLPE +  +++ +   VF GGD+AG+A TTVE+VNDGKQA+W+IH YLQ+ +   +   +P+LPLFY+ ID VD+S+++CGIKFPNPFGLASAPPT S SMIRR FE GWGFA+TKTF+LDKDLVTNVSPRI+RG TSG +YGP QGSFLN+EL+SEK A YW + + EL+ DFP+ ++I+SI CS+N+ DW +L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +G  WP +G DKRTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFTLI+D   GLKALL+++ IEEL DW+ QSP T+ H KGKP+     +  K +P FG +L+E++  I N   +L    DK  PS     N  KK +  V+++I ++L  IG ++ LN +EQV A+IDE+MCINCGKCYM CNDSGYQAI FDP TH+P V + CTGC LC +VCPIVDCI MV +T  +V  RG+
Sbjct:    4 MLSKDLPDIESILALNPRVRSHAALYSTAAKKTEKKHWKRNTEKGCDSCVKLENNFDDIKHTTLSERGALREAMRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQVRNPHLPPPEQMPESYH-SKIALIGCGPASISCATFLARLGYSDITIFEKQKYVGGLSSSEIPQFRLPYEVVQFELDLMKDLGVKVVCEKGLGENGMTLLSLKEEGYKAVFIGIGLPQANRHRIFEGLSVEQGFYTSKDFLPLVAKASKPGMCACGWTLPRLHGSVIVLGAGDTAFDCATSALRCGAQRVYVVFRRGFTNIRAVPEEMELAKEEKCEFLPFLSPREVLLKG--GRVHGMEFCRTEQTETGDWVEDQEQITRLKADFIISAFGSVLSDPKVKEAMAPIRLNRWGLPELNPESMQCSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHKYLQAIHGQTVSA-QPQLPLFYSPIDSVDISVQMCGIKFPNPFGLASAPPTTSTSMIRRAFEQGWGFALTKTFSLDKDLVTNVSPRIVRGTTSGPIYGPAQGSFLNIELISEKTAAYWCQSVTELKADFPHNIIISSIMCSYNKADWTELAKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADGSPWPGIGRDKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTLIEDYCMGLKALLYLKSIEELQDWDGQSPPTAPHQKGKPVPRLEELVGKKLPSFGPYLEEKKMAIANYKKKLPNLIDKTIPSSASRINTAKKPVPTVQDVIARALKHIGAYQELNNQEQVQALIDEEMCINCGKCYMTCNDSGYQAITFDPETHLPVVQDSCTGCTLCLSVCPIVDCIRMVARTTPYVPKRGL 1018
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. TrEMBL
Match: A0A147BNB5 (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Ixodes ricinus OX=34613 PE=3 SV=1)

HSP 1 Score: 1317.37 bits (3408), Expect = 0.000e+0
Identity = 650/1018 (63.85%), Postives = 787/1018 (77.31%), Query Frame = 3 
Query:  150 YLLMLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQN-HFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTK-PELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVP-------KKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            Y+  LS D PDIEN+L+LNPK  + A + PS  TK  K  WKRN DK CS+C+ LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPTQLDIK+FI+SI+ KNYYGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFATD+F++MKIPQIR P+L   H L    ++ I LIGCGPAS+SCATFLARLGYS I IFEK  + GGLS++EIP+FRLPY VV FEL L+ DLGV +  NK L ++ T++ L K YS +FLG GLPD K I IF  L + QGFYTSK FLP+VSR+SKPGMC C   LP L GNVIVLGAGDTAFDCAT ALRCGA RV+++FRKGFT I  VPEEMELA+EEKCEF+PF+SP  + +N T  +I +M F +T + ++G    D +Q++ LK DFVISAFGS L D  ++++L P+++NKYGLPE +  +++T+   VFCGGDLAGV++TTVEAVNDGK A+W+IH YLQS +N  IDV K P LP FYT ID VDLS+E CGIKF NPFGLASAPPT +++MIRR F+AGWGFA+TKTF LDKD+VTNVSPRIIRG T G  YGPN GSFLN+EL+SEK A YW   I EL+KDFP+ V+IASI C  ++ DW  L+QM E  GA ALELN+SCPHGM ERG+GLACGQ P  V  IC W++KAVKIPFF KLTPN+TN++DIA+A+YEG A GVTA NTVS LM IK N + WP VGT KRTTYGGMSGNAIRPI+MRAVSAIA+++PGFPILATGGIDSAE   +FL  GA+ +Q+CS+IQNQDFT+I+D +TGL+A L+I+ ++ + DW  QSP    H KGKPI     I  + +P FG +L+++E  I  +    D    ++VP       K+ I KV+++IG+SL +IG F  L+L++QVVA+IDEDMCINCGKCYM CNDSGYQAI FD  TH+P VT DCTGC LC +VCPI +CI M+ +       RG+
Sbjct:    6 YMHRLSVDPPDIENILALNPKIKETATITPSAVTKKNKHHWKRNIDKKCSSCKPLEKNFDDIKHTTLSERGALREAARCLKCADAPCQKSCPTQLDIKAFISSISTKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATDVFKEMKIPQIRPPDLPPLHELPQSYKAKIALIGCGPASMSCATFLARLGYSDIVIFEKQSYFGGLSSAEIPQFRLPYDVVSFELDLVKDLGVKVEFNKALGRDFTLESLRKEYSIVFLGIGLPDPKVIPIFEGLDESQGFYTSKTFLPLVSRASKPGMCGCKQTLPSLFGNVIVLGAGDTAFDCATSALRCGANRVFVVFRKGFTNIRAVPEEMELAREEKCEFLPFLSPRNLVMNGT--RIRAMEFLRTEQADDGTWVEDEEQMVRLKADFVISAFGSTLGDISVVDALSPLKLNKYGLPEVNVESMQTSEPWVFCGGDLAGVSETTVEAVNDGKTASWHIHKYLQSLHN--IDVPKTPALPRFYTPIDLVDLSVEFCGIKFKNPFGLASAPPTTTSAMIRRAFQAGWGFALTKTFGLDKDVVTNVSPRIIRGSTFGHTYGPNLGSFLNIELISEKTAAYWCGSISELKKDFPDHVVIASIMCPLDKKDWTVLAQMAEMAGADALELNISCPHGMGERGMGLACGQNPDHVRNICSWVRKAVKIPFFAKLTPNVTNVVDIAKAAYEGKADGVTAVNTVSGLMGIKYNSDPWPGVGTQKRTTYGGMSGNAIRPIAMRAVSAIARALPGFPILATGGIDSAEAGFQFLQAGASVLQVCSSIQNQDFTVIEDYLTGLRAALYIRNLKGMEDWESQSPPVKPHQKGKPIVKLEDIENQRLPHFGPYLQKKEDLIAEEKKRSDLLSDNHVPQREVRALKEKIPKVQDVIGESLKKIGTFGDLDLKQQVVALIDEDMCINCGKCYMTCNDSGYQAITFDKDTHLPFVTNDCTGCTLCLSVCPIPECIQMIKRKTPSQPKRGI 1019
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Cavefish
Match: dpyda.3 (dihydropyrimidine dehydrogenase [Source:NCBI gene;Acc:103045749])

HSP 1 Score: 1322.76 bits (3422), Expect = 0.000e+0
Identity = 642/1019 (63.00%), Postives = 801/1019 (78.61%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNEL----DKCCPS-----NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            MLS+DLPDIE++L+LNP+   +A L  +   K+EK  WKRN +K C +C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+ I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQ+R+P+L        SY  S I LIGCGPASISCATFLARLGYS I IFEK  + GGLS+SEIP+FRLPY+VV FEL LM DLGV +   K L +N MT+  L +  Y A+F+G GLP A    IF  L+ EQGFYTSK FLP+V+++SKPGMCAC + LP+LHG+VIVLGAGDTAFDCAT ALRCGA+RVY++FR+GFT I  VPEEMELAKEEKCEF+PF+SP +V L     ++H M F +T + E G+   D +QI  LK DF+ISAFGS L+D ++ E++ P+R+N++GLPE +  +++ +   VF GGD+AG+A TTVE+VNDGKQA+W+IH YLQ+ +   +   +P+LPLFY+ ID VD+S+++CGIKFPNPFGLASAPPT S SMIRR FE GWGFA+TKTF+LDKDLVTNVSPRI+RG TSG +YGP QGSFLN+EL+SEK A YW + + EL+ DFP+ ++I+SI CS+N+ DW +L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +G  WP +G DKRTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFTLI+D   GLKALL+++ IEEL DW+ QSP T+ H KGKP+     +  K +P FG +L+E++  I N   +L    DK  PS     N  KK +  V+++I ++L  IG ++ LN +EQV A+IDE+MCINCGKCYM CNDSGYQAI FDP TH+P V + CTGC LC +VCPIVDCI MV +T  +V  RG+
Sbjct:    4 MLSKDLPDIESILALNPRVRSHAALYSTAAKKTEKKHWKRNTEKGCDSCVKLENNFDDIKHTTLSERGALREAMRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQVRNPHLPPPEQMPESYH-SKIALIGCGPASISCATFLARLGYSDITIFEKQKYVGGLSSSEIPQFRLPYEVVQFELDLMKDLGVKVVCEKGLGENGMTLLSLKEEGYKAVFIGIGLPQANRHRIFEGLSVEQGFYTSKDFLPLVAKASKPGMCACGWTLPRLHGSVIVLGAGDTAFDCATSALRCGAQRVYVVFRRGFTNIRAVPEEMELAKEEKCEFLPFLSPREVLLKG--GRVHGMEFCRTEQTETGDWVEDQEQITRLKADFIISAFGSVLSDPKVKEAMAPIRLNRWGLPELNPESMQCSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHKYLQAIHGQTVSA-QPQLPLFYSPIDSVDISVQMCGIKFPNPFGLASAPPTTSTSMIRRAFEQGWGFALTKTFSLDKDLVTNVSPRIVRGTTSGPIYGPAQGSFLNIELISEKTAAYWCQSVTELKADFPHNIIISSIMCSYNKADWTELAKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADGSPWPGIGRDKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTLIEDYCMGLKALLYLKSIEELQDWDGQSPPTAPHQKGKPVPRLEELVGKKLPSFGPYLEEKKMAIANYKKKLPNLIDKTIPSSASRINTAKKPVPTVQDVIARALKHIGAYQELNNQEQVQALIDEEMCINCGKCYMTCNDSGYQAITFDPETHLPVVQDSCTGCTLCLSVCPIVDCIRMVARTTPYVPKRGL 1018
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Cavefish
Match: dpyda.3 (dihydropyrimidine dehydrogenase [Source:NCBI gene;Acc:103045749])

HSP 1 Score: 1303.89 bits (3373), Expect = 0.000e+0
Identity = 633/1010 (62.67%), Postives = 792/1010 (78.42%), Query Frame = 3 
Query:  186 ENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNEL----DKCCPS-----NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +++L+LNP+   +A L  +   K+EK  WKRN +K C +C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+ I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQ+R+P+L        SY  S I LIGCGPASISCATFLARLGYS I IFEK  + GGLS+SEIP+FRLPY+VV FEL LM DLGV +   K L +N MT+  L +  Y A+F+G GLP A    IF  L+ EQGFYTSK FLP+V+++SKPGMCAC + LP+LHG+VIVLGAGDTAFDCAT ALRCGA+RVY++FR+GFT I  VPEEMELAKEEKCEF+PF+SP +V L     ++H M F +T + E G+   D +QI  LK DF+ISAFGS L+D ++ E++ P+R+N++GLPE +  +++ +   VF GGD+AG+A TTVE+VNDGKQA+W+IH YLQ+ +   +   +P+LPLFY+ ID VD+S+++CGIKFPNPFGLASAPPT S SMIRR FE GWGFA+TKTF+LDKDLVTNVSPRI+RG TSG +YGP QGSFLN+EL+SEK A YW + + EL+ DFP+ ++I+SI CS+N+ DW +L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +G  WP +G DKRTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFTLI+D   GLKALL+++ IEEL DW+ QSP T+ H KGKP+     +  K +P FG +L+E++  I N   +L    DK  PS     N  KK +  V+++I ++L  IG ++ LN +EQV A+IDE+MCINCGKCYM CNDSGYQAI FDP TH+P V + CTGC LC +VCPIVDCI MV +T  +V  RG+
Sbjct:   45 QSILALNPRVRSHAALYSTAAKKTEKKHWKRNTEKGCDSCVKLENNFDDIKHTTLSERGALREAMRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQVRNPHLPPPEQMPESYH-SKIALIGCGPASISCATFLARLGYSDITIFEKQKYVGGLSSSEIPQFRLPYEVVQFELDLMKDLGVKVVCEKGLGENGMTLLSLKEEGYKAVFIGIGLPQANRHRIFEGLSVEQGFYTSKDFLPLVAKASKPGMCACGWTLPRLHGSVIVLGAGDTAFDCATSALRCGAQRVYVVFRRGFTNIRAVPEEMELAKEEKCEFLPFLSPREVLLKG--GRVHGMEFCRTEQTETGDWVEDQEQITRLKADFIISAFGSVLSDPKVKEAMAPIRLNRWGLPELNPESMQCSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHKYLQAIHGQTVSA-QPQLPLFYSPIDSVDISVQMCGIKFPNPFGLASAPPTTSTSMIRRAFEQGWGFALTKTFSLDKDLVTNVSPRIVRGTTSGPIYGPAQGSFLNIELISEKTAAYWCQSVTELKADFPHNIIISSIMCSYNKADWTELAKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADGSPWPGIGRDKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTLIEDYCMGLKALLYLKSIEELQDWDGQSPPTAPHQKGKPVPRLEELVGKKLPSFGPYLEEKKMAIANYKKKLPNLIDKTIPSSASRINTAKKPVPTVQDVIARALKHIGAYQELNNQEQVQALIDEEMCINCGKCYMTCNDSGYQAITFDPETHLPVVQDSCTGCTLCLSVCPIVDCIRMVARTTPYVPKRGL 1050
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Cavefish
Match: dpyda.3 (dihydropyrimidine dehydrogenase [Source:NCBI gene;Acc:103045749])

HSP 1 Score: 1239.17 bits (3205), Expect = 0.000e+0
Identity = 604/962 (62.79%), Postives = 757/962 (78.69%), Query Frame = 3 
Query:  186 ENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNEL----DKCCPS-----NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQ 3017
            +++L+LNP+   +A L  +   K+EK  WKRN +K C +C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+ I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQ+R+P+L        SY  S I LIGCGPASISCATFLARLGYS I IFEK  + GGLS+SEIP+FRLPY+VV FEL LM DLGV +   K L +N MT+  L +  Y A+F+G GLP A    IF  L+ EQGFYTSK FLP+V+++SKPGMCAC + LP+LHG+VIVLGAGDTAFDCAT ALRCGA+RVY++FR+GFT I  VPEEMELAKEEKCEF+PF+SP +V L     ++H M F +T + E G+   D +QI  LK DF+ISAFGS L+D ++ E++ P+R+N++GLPE +  +++ +   VF GGD+AG+A TTVE+VNDGKQA+W+IH YLQ+ +   +   +P+LPLFY+ ID VD+S+++CGIKFPNPFGLASAPPT S SMIRR FE GWGFA+TKTF+LDKDLVTNVSPRI+RG TSG +YGP QGSFLN+EL+SEK A YW + + EL+ DFP+ ++I+SI CS+N+ DW +L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +G  WP +G DKRTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFTLI+D   GLKALL+++ IEEL DW+ QSP T+ H KGKP+     +  K +P FG +L+E++  I N   +L    DK  PS     N  KK +  V+++I ++L  IG ++ LN +EQV A+IDE+MCINCGKCYM CNDSGYQ
Sbjct:   45 QSILALNPRVRSHAALYSTAAKKTEKKHWKRNTEKGCDSCVKLENNFDDIKHTTLSERGALREAMRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQVRNPHLPPPEQMPESYH-SKIALIGCGPASISCATFLARLGYSDITIFEKQKYVGGLSSSEIPQFRLPYEVVQFELDLMKDLGVKVVCEKGLGENGMTLLSLKEEGYKAVFIGIGLPQANRHRIFEGLSVEQGFYTSKDFLPLVAKASKPGMCACGWTLPRLHGSVIVLGAGDTAFDCATSALRCGAQRVYVVFRRGFTNIRAVPEEMELAKEEKCEFLPFLSPREVLLKG--GRVHGMEFCRTEQTETGDWVEDQEQITRLKADFIISAFGSVLSDPKVKEAMAPIRLNRWGLPELNPESMQCSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHKYLQAIHGQTVSA-QPQLPLFYSPIDSVDISVQMCGIKFPNPFGLASAPPTTSTSMIRRAFEQGWGFALTKTFSLDKDLVTNVSPRIVRGTTSGPIYGPAQGSFLNIELISEKTAAYWCQSVTELKADFPHNIIISSIMCSYNKADWTELAKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADGSPWPGIGRDKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTLIEDYCMGLKALLYLKSIEELQDWDGQSPPTAPHQKGKPVPRLEELVGKKLPSFGPYLEEKKMAIANYKKKLPNLIDKTIPSSASRINTAKKPVPTVQDVIARALKHIGAYQELNNQEQVQALIDEEMCINCGKCYMTCNDSGYQ 1002
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Cavefish
Match: dpyda.3 (dihydropyrimidine dehydrogenase [Source:NCBI gene;Acc:103045749])

HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0
Identity = 318/504 (63.10%), Postives = 391/504 (77.58%), Query Frame = 3 
Query:  186 ENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNL--QNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLL-KSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNN 1685
            +++L+LNP+   +A L  +   K+EK  WKRN +K C +C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+ I SDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT++F +M IPQ+R+P+L        SY  S I LIGCGPASISCATFLARLGYS I IFEK  + GGLS+SEIP+FRLPY+VV FEL LM DLGV +   K L +N MT+  L  + Y A+F+G GLP A    IF  L+ EQGFYTSK FLP+V+++SKPGMCAC + LP+LHG+VIVLGAGDTAFDCAT ALRCGA+RVY++FR+GFT I  VPEEMELAKEEKCEF+PF+SP +V L     ++H M F +T + E G+   D +QI  LK DF+ISAFGS L+D ++ E++ P+R+N++GLPE +  +++ +   VF GGD+AG+A TTVE+VNDGKQA+W+IH YLQ    N
Sbjct:   45 QSILALNPRVRSHAALYSTAAKKTEKKHWKRNTEKGCDSCVKLENNFDDIKHTTLSERGALREAMRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQVRNPHLPPPEQMPESYH-SKIALIGCGPASISCATFLARLGYSDITIFEKQKYVGGLSSSEIPQFRLPYEVVQFELDLMKDLGVKVVCEKGLGENGMTLLSLKEEGYKAVFIGIGLPQANRHRIFEGLSVEQGFYTSKDFLPLVAKASKPGMCACGWTLPRLHGSVIVLGAGDTAFDCATSALRCGAQRVYVVFRRGFTNIRAVPEEMELAKEEKCEFLPFLSPREVLLKG--GRVHGMEFCRTEQTETGDWVEDQEQITRLKADFIISAFGSVLSDPKVKEAMAPIRLNRWGLPELNPESMQCSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHKYLQDLVTN 545

HSP 2 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 268/439 (61.05%), Postives = 343/439 (78.13%), Query Frame = 3 
Query: 1887 KDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNEL----DKCCPS-----NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +DLVTNVSPRI+RG TSG +YGP QGSFLN+EL+SEK A YW + + EL+ DFP+ ++I+SI CS+N+ DW +L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W+++AVKIPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +G  WP +G DKRTTYGG+SGNAIRPI++RAVSAIA+++PGFPILATGGIDSAE+ L+FL+ GA+ +Q+CSA+QNQDFTLI+D   GLKALL+++ IEEL DW+ QSP T+ H KGKP+     +  K +P FG +L+E++  I N   +L    DK  PS     N  KK +  V+++I ++L  IG ++ LN +EQV A+IDE+MCINCGKCYM CNDSGYQAI FDP TH+P V + CTGC LC +VCPIVDCI MV +T  +V  RG+
Sbjct:  540 QDLVTNVSPRIVRGTTSGPIYGPAQGSFLNIELISEKTAAYWCQSVTELKADFPHNIIISSIMCSYNKADWTELAKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADGSPWPGIGRDKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTLIEDYCMGLKALLYLKSIEELQDWDGQSPPTAPHQKGKPVPRLEELVGKKLPSFGPYLEEKKMAIANYKKKLPNLIDKTIPSSASRINTAKKPVPTVQDVIARALKHIGAYQELNNQEQVQALIDEEMCINCGKCYMTCNDSGYQAITFDPETHLPVVQDSCTGCTLCLSVCPIVDCIRMVARTTPYVPKRGL 978
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Cavefish
Match: dhodh (dihydroorotate dehydrogenase (quinone) [Source:NCBI gene;Acc:103040150])

HSP 1 Score: 59.6918 bits (143), Expect = 9.021e-9
Identity = 86/344 (25.00%), Postives = 148/344 (43.02%), Query Frame = 3 
Query: 1734 DKVDLSIEICGIKFPNPFGLASA-PPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNE-DDWIKLSQMVEEVG--AQALELNLSCPHGMSERGLGLACGQIPRIVIEICQW---IKKAVKIPFFVKLTPNIT--NILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTD-KRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSK 2723
            D   L + + G +F NP G+A+     G A  +   ++ G+GF    T T  K    N  PR+ R      +   YG N    L VE   + +A   L+  +  R   P  + +     S +   D++   + V  +G  A  L +N+S P+    R L     ++  ++ ++ +    ++     P  VK+ P+++  +  DIA    E G  G+  +NT  S           P    D K+   GG+SG  ++ +S R V  +     G  PI+  GGI   ++AL  +  GA+ VQ+ +A+  Q   ++  +   L  LL  QG   +S+      +TS+
Sbjct:   73 DPASLEVTVMGQRFRNPVGMAAGFDKHGEA--VDTLYQLGFGFVEVGTVT-PKPQEGNPKPRVFRLEADQAVINRYGFNSCGLLAVEERLKTRAGTQLELARAGR---PLGINLGKNKLSTDAVADYL---EGVRTLGPLADYLVINVSSPNTPGLRDL-QGKKELRHLLAKVLKERDSLQGKNGPPVLVKIAPDLSQQDKQDIAEVITELGVDGLIVSNTTVS----------RPETLQDPKKNEIGGLSGQPLKDMSTRMVREMYTLTKGKVPIIGVGGIACGQDALDKIRAGASLVQLYTALVYQGPPVVTKIKRELDELLIAQGFTNVSEAVGADFRTSE 396
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008220.1 (pep scaffold:Pmarinus_7.0:GL496871:193:1202:1 gene:ENSPMAG00000007438.1 transcript:ENSPMAT00000008220.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 121.324 bits (303), Expect = 1.062e-32
Identity = 52/96 (54.17%), Postives = 72/96 (75.00%), Query Frame = 3 
Query: 2874 ENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGV 3161
            +++IG++L  IG +  L+  +QVVA++D ++CINCGKCY+ CNDSGYQAI+F    H+P VT+ CTGC LC +VCPI DCITMV +   ++  RGV
Sbjct:    9 QDVIGRALAHIGSYAELDNSQQVVAVVDPELCINCGKCYLTCNDSGYQAIEFGGHDHVPLVTDRCTGCTLCLSVCPIHDCITMVTRPTPYIPQRGV 104
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Sea Lamprey
Match: dhodh (dihydroorotate dehydrogenase [Source:ZFIN;Acc:ZDB-GENE-030131-3157])

HSP 1 Score: 50.8322 bits (120), Expect = 1.003e-6
Identity = 52/195 (26.67%), Postives = 92/195 (47.18%), Query Frame = 3 
Query: 2133 AQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIP----FFVKLTPNITN--ILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPC-VGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSD 2693
            A  L +N+SCP+    + L   C ++ R +++     + A+  P      +K+ P++T+    DIA    E G  G+  +NT  S           P  + +  RT  GG+SG  +R +S + V  + K   G  PI+  GGI +  +A + +  GA+ VQ+ +A+  Q   +I  +   L+ LL   G   +++
Sbjct:  200 ADYLVVNVSCPNTPGLQVL-QGCSEL-RALLQQVVRARDALPTPHRPALLLKIAPDLTDEAKRDIAAVVTEMGVDGLIVSNTTLS----------RPAGLQSAHRTETGGLSGVPLRELSTQTVRDMYKLTGGSVPIVGVGGITNGADAFEKINAGASLVQLYTALMYQGPPVIARVKRELQDLLSEHGYSSVAE 382
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Yeast
Match: GLT1 (NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions [Source:SGD;Acc:S000002330])

HSP 1 Score: 85.1149 bits (209), Expect = 4.112e-17
Identity = 82/313 (26.20%), Postives = 132/313 (42.17%), Query Frame = 3 
Query:  327 NDVKPTT--LSERGALKEANRCLKCADAPC--QKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFG------LP----DAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGN-VIVLGAGDTAFDCATCALRCGAKRV 1217
            ND K  T  ++++ A  +  RC+ C    C     CP    I  F   +    +  A   +   N      G VCP    C G+C L G  E P+ I  +++   D  F++  I     P+ +  F       ++ +IG GPA ++CA  L R G++ + ++E+ D  GGL    IP  +L   +V   + L+   G+    N  + K +++ +L   ++A+    G      LP    + KNID    L +        K L I+                ++ G  VIV+G GDT  DC   ++R GA  V
Sbjct: 1662 NDWKEFTNPITKKDAKYQTARCMDCGTPFCLSDTGCPLSNIIPKFNELLFKNQWKLALDKLLETNNFPEFTGRVCPAP--CEGACTL-GIIEDPVGIKSVERIIIDNAFKEGWIKPC-PPSTRTGF-------TVGVIGSGPAGLACADMLNRAGHT-VTVYERSDRCGGLLMYGIPNMKLDKAIVQRRIDLLSAEGIDFVTNTEIGKTISMDELKNKHNAVVYAIGSTIPRDLPIKGRELKNIDFAMQLLESNTKALLNKDLEIIRE--------------KIQGKKVIVVGGGDTGNDCLGTSVRHGAASV 1948
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Yeast
Match: URA1 (Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid [Source:SGD;Acc:S000001699])

HSP 1 Score: 69.3218 bits (168), Expect = 5.826e-13
Identity = 52/235 (22.13%), Postives = 111/235 (47.23%), Query Frame = 3 
Query: 2004 EYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQAL-ELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTP--NITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSI-PGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDW 2696
            +Y+L  +   +K++P+   I       + D+ + L + +++     + ELNLSCP+   +  +          + ++  + KK    P  VKL P  +  +   +A+   E   + V + N++ + + I V  E+   V    +  +GG+ G  ++P ++  V A    + P   ++ TGGI S ++A + L CGA+ +QI + +Q +   + + +   LK ++  +G   +  +
Sbjct:   80 DYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKK----PLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKES---VVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQF 307
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Nematostella
Match: EDO36177 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJG5])

HSP 1 Score: 1292.33 bits (3343), Expect = 0.000e+0
Identity = 626/1012 (61.86%), Postives = 785/1012 (77.57%), Query Frame = 3 
Query:  156 LMLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTC-ESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPL--SKNMTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFL---------KEREKDIINQNNELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPK 3131
            + LS   P+IENLLSLNP   K A +VP+  TK  K  WKRN DK+C +C E+   NF+D+K TTLSERGALKEA RCLKC DAPCQKSCPTQLDIK FI+ IANKN+YGAAK IFSDNPLGLTCGMVCPTSDLCVG CNLY +EEGPINIGGLQQFAT+IF+ MK+PQIRDP+L   +    SY+ S I LIGCGPASISCATFL RLGY+ + IFEK  F GGLS++EIP+FRLPY VVDFE++LM+DLGV +   + L  S  +T++ L    Y  IFLG GLP  K   +F  L+++ GFYTSK FLP+VS  SKPGMCAC   LPQL  NVIVLGAGDTAFDC T ALRCGA+RV+++FRKGFT I  VPEEM+LA +EKCEF+PFMSP +V +     KI +M F +T + ++G    D +Q L +K  FVISAFGS L+++++ ++L P++ NK+GLPE    T+ T+ E VFCGGDLAG+A TTVE+VNDGKQAAW++H +LQS +   I  ++P LP F+T +D+VDLS+EICGIKFPNPFGLASAPPT +++MIRRGFEAGWGFA+TKTF+LDKD+VTNVSPRI+RG TSG LYGP QGSFLN+EL+SEK + YW + I EL+KDFP+++LIASI C +++ DW  L++M E  GA ALELNLSCPHGM ERG+GLACGQ   +V  IC+W++ A+ IPFF KLTPN+T+I+ IARA+ EG A GVTATNTVS LM +K   EAWP +G +KRTTYGGMSGNAIRPI++RAVSAI +++PGFPILATGGIDSA+ AL+FL+CGA+A+Q+CSA+QNQDFT++DD I GLK L++++ ++E +DW  QSP T +H +GKP+     +  K +P FG +L          +R  DI+++  E +   P+    K    V++++G +L++IG +  L+  +QVVA+IDE+MCINCGKCYM CNDSGYQAIKFDP TH+PTVT+DCTGC LC +VCPI+DCI MV +
Sbjct:    1 MALSTHSPEIENLLSLNPSIPKKANIVPTAVTKKNKKHWKRNADKSCGSCSEAFIKNFDDIKHTTLSERGALKEAGRCLKCVDAPCQKSCPTQLDIKYFISCIANKNFYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYASEEGPINIGGLQQFATEIFKNMKLPQIRDPDLTPVDQLPESYK-SKIALIGCGPASISCATFLGRLGYTNLTIFEKEKFIGGLSSAEIPQFRLPYSVVDFEVKLMMDLGVKVETGRGLGVSSGLTIQSLKNDGYKGIFLGMGLPQPKKFHVFEGLSEQNGFYTSKSFLPVVSSGSKPGMCACKSSLPQLSDNVIVLGAGDTAFDCCTSALRCGARRVFVVFRKGFTNIRAVPEEMQLAVDEKCEFLPFMSPKQVHVKD--GKIVAMEFFRTEQLDDGTWTEDAEQTLKIKATFVISAFGSTLSNEDVKQALAPIKFNKWGLPEVSAETMATSAEGVFCGGDLAGIANTTVESVNDGKQAAWFMHQHLQSLHVLTIP-SEPALPRFFTPVDQVDLSVEICGIKFPNPFGLASAPPTTTSAMIRRGFEAGWGFALTKTFSLDKDIVTNVSPRIVRGTTSGHLYGPGQGSFLNIELISEKTSAYWCRSITELKKDFPDKILIASIMCGYSKQDWTTLAKMAEAAGADALELNLSCPHGMGERGMGLACGQDAELVRNICRWVRAAITIPFFAKLTPNVTDIVVIARAAKEGNADGVTATNTVSGLMGLKGTSEAWPAIGREKRTTYGGMSGNAIRPIALRAVSAIGRALPGFPILATGGIDSADAALQFLHCGASALQVCSAVQNQDFTVVDDYINGLKCLMYMKSVDEYADWEGQSPPTPRHQQGKPVPKIADLVGKGLPSFGPYLVKRNEIIAAHKRSSDILSKEYEPEPVRPAVKQSKPTPSVKDVVGLALDRIGTYGDLDNRQQVVALIDEEMCINCGKCYMTCNDSGYQAIKFDPETHLPTVTDDCTGCTLCLSVCPIIDCIKMVQR 1008
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Nematostella
Match: EDO38711 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC78])

HSP 1 Score: 90.5077 bits (223), Expect = 2.708e-18
Identity = 82/306 (26.80%), Postives = 130/306 (42.48%), Query Frame = 3 
Query:  321 NFNDVKPTTLSERGALKEANRCLKCADAPCQK--SCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD-IFRQMKI-PQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHG---NVIVLGAGDTAFDCATCALRCGAKRV 1217
            ++ ++     S+R    +A RC+ C    CQ    CP    I  +   +    + GA + +   N      G VCP    C G+C L       + I  ++    D  F Q  I PQI           +     + +IG GPA +S A  L + G+ K+ ++EK D  GGL    IP  +L  K+V   L LM   G+T      + +++T   L+    A+ +  G    +++ I       +G + +  FL   S+  + G     Y LP L     +VIV+G GDT  DC   ++R  AK +
Sbjct: 1314 DWKEIYNHKRSDRNLKVQAARCMDCGVPFCQSHAGCPLGNIIPKWNDLVFQDKWQGALERLLQTNSFPEFTGRVCPAP--CEGACVL-AINAKAVTIKKIECTIIDHAFEQGWIKPQIP---------MTRTGKKVAIIGSGPAGLSAAVQLNKAGH-KVTVYEKNDRCGGLLMYGIPSMKLDKKIVQRRLNLMEQEGITFVTKSEVGRDVTANQLMADNDAVLMAVGSTWPRDLPIPG--RSLEGVHFAMNFLE-TSQKRQMG----DYSLPSLDATGKHVIVIGGGDTGVDCIATSVRQDAKSI 1599
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Nematostella
Match: EDO26058 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TD00])

HSP 1 Score: 78.1814 bits (191), Expect = 1.805e-15
Identity = 77/307 (25.08%), Postives = 139/307 (45.28%), Query Frame = 3 
Query:  786 IEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRV--YIIFRK---GFTTISP---VPXXXXXXXXXXXXFIPFMSPYKVEL--NKTTNKI--HSMAFHKTF-ENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYL 1667
            + +FE+    GGL    IP+F+L  +++D  ++++++ G+    N  + KN++V+ +   Y A+ +  G  + + I I  +    +G Y + +FL + +     G+      +      VIV+G GDT  DC   + R GA  V  + I  K   G     P    P +++     K     F S    E   +K  N I   ++A    F E E  ++   P+   + + D V+ A G    ++ L E L      +  +   +K    TN++ +F  GD+       V A+++G+QAA+Y+  YL
Sbjct:    4 VTVFERDSKVGGLLRYGIPDFKLEKQIIDRRVEVLIEEGIIFKTNAYVGKNISVETIKADYDAVLMCGGATERRGIPIKGN--HLKGVYQAMEFLKL-NNQYVDGLIKFDDVISAKDKKVIVIGGGDTGSDCIGTSNRHGAVSVANFEILTKPTVGRPANQPWPYWPMKLKTTSSHKEGVERFFSISTKEFLGDKKGNLIGLKTVAVEWIFKEGERPQLIEVPNTEKSWECDMVLLALGFTGAEKTLAEQLGVEMDFRTNIKATEK-DYATNVKGIFAAGDMRRGQSLIVWAISEGRQAAYYVDKYL 306
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Nematostella
Match: EDO35448 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLG1])

HSP 1 Score: 54.299 bits (129), Expect = 1.549e-7
Identity = 81/339 (23.89%), Postives = 141/339 (41.59%), Query Frame = 3 
Query: 1746 LSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQ-GSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVG-----AQALELNLSCPHGMSERGLG--LACGQIPRIVIEICQWIKKAVKIPFFVKLTPNIT--NILDIARASYEGGAS--GVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQG---IEELSDWNYQ 2705
            L+ ++ G++F NP GLA+      A  +    + G+GF    + T +     N  PR+ R      +   YG N  G     + L ++ A          R   P  VL  ++  +    D +  S  V+ V      A  L +N+S P+    R L       Q+    +E  +    + + P  VK+ P++T  + +DIA      G    G+  +NT  +             + +  +T  GG+SG  +R +S  AV  + +   G  PI+  GGI S ++A   +  GA+ VQ+ +A+  Q   ++  +   L  LL   G   ++E    N++
Sbjct:   80 LNTKVFGLQFSNPVGLAAGFDK-HAEAVDGLLKMGFGFVEVGSVTPEPQ-PGNPKPRVFRLVEDQAVINRYGFNSDGHKAASKRLQDRLA----------RSGHPKGVLGINVGKNKTSPDAV--SDYVKGVKCFSPLAHYLVINISSPNTPGLRALQGREELTQLIDNALEARRQASPSAQPPLLVKIAPDLTEEDKIDIASVITRQGHQIDGLIVSNTTITRPS---------TLQSPNKTEQGGLSGAPLREMSTGAVGDMYRLTEGKIPIIGVGGISSGQDAYDKIKAGASLVQLYTALAYQGPPVVRKIKRELAELLRKDGFGSVQEAVGINHK 395
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Nematostella
Match: EDO27412 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9B5])

HSP 1 Score: 50.447 bits (119), Expect = 8.793e-7
Identity = 44/142 (30.99%), Postives = 71/142 (50.00%), Query Frame = 3 
Query: 2259 IPFFVKLTPNITN--ILDIARA--SYEGGASGVTATNTVSSLMHIK---VNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKAL 2660
            +P  VK+ P++T   +  +A +  +YE    GV ATNT  S   ++   V+ EA            GG+SG  +R  S R +  ++K + G  PI+  GGI    +A + +  GA+ VQI S    +  +LI D +  ++AL
Sbjct:   77 VPIAVKIAPDMTEEEVAMVAESLKTYE--IDGVIATNTTLSREGVEDSPVHHEA------------GGLSGAPVRNKSTRVIRLLSKELSGALPIIGVGGITEGFDAAEKIEAGASLVQIYSGFIYKGPSLITDSVRAIQAL 204
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Medaka
Match: dpydb (dihydropyrimidine dehydrogenase [Source:NCBI gene;Acc:101175598])

HSP 1 Score: 1268.45 bits (3281), Expect = 0.000e+0
Identity = 632/1026 (61.60%), Postives = 785/1026 (76.51%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDI------INQNNELDKCCPS----NVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY*N*MC 3179
            MLS+DLPDIE++L+LNP+   +A++  +   K EK  WKRN +KNC  C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+VI SDNPLGLTCGMVCPTS+LCVG CNLY +EEGPINIGGLQQFAT++F QM IPQIR P L   N    SY  S + +IGCGPASISCA+FLARLGY  I IFEK  + GGLSTSEIP+FRLPY+VV FE++LM DLGV +   K L  N MT+  L K  + A+F+G GLP A    IF  LT +QGF+TSK FLP+V+ +SK GMC C   LP+L G VIVLGAGDTAFDCAT ALRCGA+RVY+ FRKGFT I  VPEEMELAKEEKCEF+PF+SP +V +     ++  + F +T + E G+   D +Q++ LK D++ISAFGS L D ++ E++ PV+++ +G PE +  T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH Y+QS Y   ++ T P+LPLFY+AID+VD+S+E+CGIKFPNPFGLASAPPT S +MIRR FE GWGFA+TKTF LDKDLVTNVSPRI+RG TSG LYGP  GSFLN+EL+SEK A YW + + EL+KDFP  V+I+SI C++N+DDW  L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W++ AV IPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +   WP VG  KRTTYGG+SGNAIRPI+++AVSAIAK+IPGFPILATGGIDSAE  L+FL+ GA+ +Q+CSAIQNQDFT+I+D   GLKALL+++ + EL DW+ QSP T KH KGK +     +  K +P FG +L+++ + I      +    E D   P+    N P K +  V+++I ++L  IG ++ L+  EQV A+IDEDMCINCGKCYM CNDSGYQAI+FDP TH+P VT+ CTGC LC  VCPI+DCI MV +   H+  RG+  N +C
Sbjct:    1 MLSKDLPDIESILALNPRVKTHAQITSTASKKKEKKHWKRNPEKNCDFCVKLENNFDDIKHTTLSERGALREAYRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARVILSDNPLGLTCGMVCPTSELCVGGCNLYASEEGPINIGGLQQFATEVFSQMGIPQIRSPELPPPNEMPESYH-SPVAMIGCGPASISCASFLARLGYDNITIFEKQQYIGGLSTSEIPQFRLPYEVVQFEIELMKDLGVKVVCEKGLGVNGMTLTSLKKEGFKAVFIGIGLPQANRAKIFQGLTGDQGFFTSKDFLPLVASASKKGMCQCRSALPELRGAVIVLGAGDTAFDCATSALRCGARRVYVCFRKGFTNIRAVPEEMELAKEEKCEFLPFLSPREVIMK--NGRVAGLQFCRTEQTEEGDWVEDEEQVVKLKADYIISAFGSILNDPKVTEAMAPVKLSHWGTPEVNTETMQTSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHRYIQSLYGQTVE-TAPKLPLFYSAIDQVDISVEMCGIKFPNPFGLASAPPTTSTAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIVRGTTSGPLYGPGLGSFLNIELISEKTAAYWCQSVAELKKDFPKNVVISSIMCAYNKDDWTVLAKMAEASGADALELNLSCPHGMGERGMGLACGQDPVLVRNICRWVRAAVSIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADSSPWPGVGAAKRTTYGGVSGNAIRPIALKAVSAIAKAIPGFPILATGGIDSAETGLQFLHAGASVLQVCSAIQNQDFTVIEDYCLGLKALLYLKSL-ELKDWDGQSPPTQKHQKGKSVPKVQELVGKGLPSFGPYLQQKTEAIAKYKKKLRDAGETDVKQPNISRINTPPKPVPAVKDVIARALRHIGAYQELDNMEQVQALIDEDMCINCGKCYMTCNDSGYQAIQFDPETHLPFVTDSCTGCTLCLTVCPIIDCIQMVTRKTPHIPQRGIPINPVC 1021
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Medaka
Match: dpydb (dihydropyrimidine dehydrogenase [Source:NCBI gene;Acc:101175598])

HSP 1 Score: 1246.88 bits (3225), Expect = 0.000e+0
Identity = 626/1018 (61.49%), Postives = 778/1018 (76.42%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQ--NHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKN-MTVKDLLK-SYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPI-----ISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALN-LEEQVV-AIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY*N*MC 3179
            MLS+DLPDIE++L+LNP+   +A++  +   K EK  WKRN +KNC  C  LE NF+D+K TTLSERGAL+EA RCLKCADAPCQKSCPT LDIK+FITSIANKNYYGAA+VI SDNPLGLTCGMVCPTS+LCVG CNLY +EEGPINIGGLQQFAT++F QM IPQIR P L   N    SY  S + +IGCGPASISCA+FLARLGY  I IFEK  + GGLSTSEIP+FRLPY+VV FE++LM DLGV +   K L  N MT+  L K  + A+F+G GLP A    IF  LT +QGF+TSK FLP+V+ +SK GMC C   LP+L G VIVLGAGDTAFDCAT ALRCGA+RVY+ FRKGFT I  VPEEMELAKEEKCEF+PF+SP +V +     ++  + F +T + E G+   D +Q++ LK D++ISAFGS L D ++ E++ PV+++ +G PE +  T++T+   VF GGD+AG+A TTVE+VNDGKQA+W+IH Y+QS Y   ++ T P+LPLFY+AID+VD+S+E+CGIKFPNPFGLASAPPT S +MIRR FE GWGFA+TKTF LDKDLVTNVSPRI+RG TSG LYGP  GSFLN+EL+SEK A YW + + EL+KDFP  V+I+SI C++N+DDW  L++M E  GA ALELNLSCPHGM ERG+GLACGQ P +V  IC+W++ AV IPFF KLTPN+TNI+DIA+A++EGGA GVTATNTVS LM +K +   WP VG  KRTTYGG+SGNAIRPI+++AVSAIAK+IPGFPILATGGIDSAE  L+FL+ GA+ +Q+CSAIQNQDFT+I+D   GLKALL+++ + EL DW+ QSP T KH KGK +     +  K +P FG +L+++ + I     +L     ++V + +I ++ N   K +  +     L  L+E  V A+IDEDMCINCGKCYM CNDSGYQAI+FDP TH+P VT+ CTGC LC  VCPI+DCI MV +   H+  RG+  N +C
Sbjct:    4 MLSKDLPDIESILALNPRVKTHAQITSTASKKKEKKHWKRNPEKNCDFCVKLENNFDDIKHTTLSERGALREAYRCLKCADAPCQKSCPTNLDIKAFITSIANKNYYGAARVILSDNPLGLTCGMVCPTSELCVGGCNLYASEEGPINIGGLQQFATEVFSQMGIPQIRSPELPPPNEMPESYH-SPVAMIGCGPASISCASFLARLGYDNITIFEKQQYIGGLSTSEIPQFRLPYEVVQFEIELMKDLGVKVVCEKGLGVNGMTLTSLKKEGFKAVFIGIGLPQANRAKIFQGLTGDQGFFTSKDFLPLVASASKKGMCQCRSALPELRGAVIVLGAGDTAFDCATSALRCGARRVYVCFRKGFTNIRAVPEEMELAKEEKCEFLPFLSPREVIMKN--GRVAGLQFCRTEQTEEGDWVEDEEQVVKLKADYIISAFGSILNDPKVTEAMAPVKLSHWGTPEVNTETMQTSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHRYIQSLYGQTVE-TAPKLPLFYSAIDQVDISVEMCGIKFPNPFGLASAPPTTSTAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIVRGTTSGPLYGPGLGSFLNIELISEKTAAYWCQSVAELKKDFPKNVVISSIMCAYNKDDWTVLAKMAEASGADALELNLSCPHGMGERGMGLACGQDPVLVRNICRWVRAAVSIPFFAKLTPNVTNIVDIAKAAHEGGADGVTATNTVSGLMGLKADSSPWPGVGAAKRTTYGGVSGNAIRPIALKAVSAIAKAIPGFPILATGGIDSAETGLQFLHAGASVLQVCSAIQNQDFTVIEDYCLGLKALLYLKSL-ELKDWDGQSPPTQKHQKGKSVPKVQELVGKGLPSFGPYLQQKTEAIAKYKKKLRDAGETDVKQPNISRI-NTPPKPVPAVKVCSTLTPLQELFVQALIDEDMCINCGKCYMTCNDSGYQAIQFDPETHLPFVTDSCTGCTLCLTVCPIIDCIQMVTRKTPHIPQRGIPINPVC 1015
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Medaka
Match: dhodh (dihydroorotate dehydrogenase (quinone) [Source:NCBI gene;Acc:101170010])

HSP 1 Score: 63.929 bits (154), Expect = 4.531e-10
Identity = 85/329 (25.84%), Postives = 139/329 (42.25%), Query Frame = 3 
Query: 1734 DKVDLSIEICGIKFPNPFGLASA-PPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGEL---YGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHN---EDDWIKLSQMVEEVG--AQALELNLSCPHGMSERGL-GLA-CGQIPRIVIEICQWIKKAVKIPFFVKLTPNIT--NILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDK-RTTYGGMSGNAIRPISMRAVSAIAKSIPG-FPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQG 2675
            D   L +   G+KF NP G+A+     G A  +   ++ G+GF    T T  K    N  PR+ R      +   YG N      V+          LK  +E ++      L   I    N   +D      + V+ +G  A  L +N+S P+    R L G A   Q+   V++    +  A + P  +K+ P++T  +  DIA    E G  G+  TNT  S           P    D  +   GG+SG  ++ +S   V  + K   G  PI+  GG+ S ++A+  +  GA+ +Q+ +++  Q   ++  +   L+ LL  QG
Sbjct:   73 DPAALEVTTLGLKFKNPIGIAAGFDKHGEA--VDALYKLGFGFVEVGTVT-PKPQEGNPKPRVFRLPADNAVINRYGFNSCGLAEVQ--------TRLKAREETQQQLTKTGLPLGINLGKNKLSQDAAADYKEGVKALGPLADYLVVNVSSPNTPGLRDLQGKAELRQLLCTVLKERDALPDAHRPPVLLKIAPDLTAQDKRDIADVVAELGVDGLMVTNTTVS----------RPETLQDPLKYETGGLSGQPLKEMSTNTVREMYKLTKGKVPIIGIGGVASGQDAMDKIRAGASLIQLYTSLTYQGPPVVTKVKRELEDLLKDQG 380
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Planmine SMEST
Match: SMESG000034030.1 (SMESG000034030.1)

HSP 1 Score: 2025.75 bits (5247), Expect = 0.000e+0
Identity = 995/1002 (99.30%), Postives = 996/1002 (99.40%), Query Frame = 3 
Query:  159 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFMSPYKVELNKTTNKIHSMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQSPKTSKHYKGKPIISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY 3164
            MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPEEMELAKEEKCEFIPFMSPYKVELNKTTNKIHSMAFHKTFENE GEIEIDPDQILTLK DFVISAFGSCLTDQELIESLKPV+INKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIP IVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDL TGLKALLHIQGIEEL DWNYQSPKTSKHYKGKPIISRKNVPFFGKFLKEREKDIINQNNELDKCC SNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY
Sbjct:    1 MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPEEMELAKEEKCEFIPFMSPYKVELNKTTNKIHSMAFHKTFENEKGEIEIDPDQILTLKADFVISAFGSCLTDQELIESLKPVKINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIHAYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPPTGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPNQGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKLSQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPSIVIEICQWIKKAVKIPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPCVGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENALKFLYCGANAVQICSAIQNQDFTLIDDLTTGLKALLHIQGIEELCDWNYQSPKTSKHYKGKPIISRKNVPFFGKFLKEREKDIINQNNELDKCCQSNVPKKSIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDSGYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRGVY 1002
[Close]
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Planmine SMEST
Match: SMESG000077776.1 (SMESG000077776.1)

HSP 1 Score: 85.5001 bits (210), Expect = 2.091e-16
Identity = 119/523 (22.75%), Postives = 210/523 (40.15%), Query Frame = 3 
Query:  174 LPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCESLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQ--KSCPTQLDIKSFITSIANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIGGLQQFATD--IFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCATFLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVTLHLNKPLSKNMTVKD-LLKSYSAIFLGFGLPDAKNIDI-FNDLTQEQGFYTSKKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGAKRVYIIFRKGFTTISPVPXXXXXXXXXXXXFIPFM----SPYKVELNKTTNKIHSMAFHKTF-ENENG--------EIEIDPD---QILTLKT----------DFVISAFGSCLTDQELIESLKPVRINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAA 1646
            L DIE+L++ N    K    +          K+ R+++   +  E +  ++ ++       +G  ++A RC++C    CQ    CP    I  +   +   N+  A   +   N      G  CP    C  +C L G  E  + I  ++    D        +P    P ++    T  R   IV++G GP+ ++ A  L + G++ + + E+ D  GGL    IP  ++   VV   +  M++ G+       +  +    D LL  Y AI L  G    ++I+I   +L+   G + +  FL    R  +        ++     +VI+LG GDT  DC   +LR GA+ V          I P P++   +     E+           +V+L    +  H     K F  +ENG        ++E   D   +  T+K           + V+ A G    ++E+I  LK + ++     +      +T++  V+  GD        V A+N+G+QAA
Sbjct: 1538 LIDIEDLVTSNTNLDKLKGFI----------KYPRHKNPYRNVEERIN-DWGEIYAHKTVRKGLRRQAARCMECGVPFCQSHHGCPLGNIIPKWNDLVYKDNWKEALTQLLQTNNFPEFTGRCCPAP--CEAACVL-GINEPAVTIKNIECAIIDKGFDEGWMVPSA--PKVK----TGKR---IVVVGSGPSGLAAAAQLNKAGHA-VLVLERNDRIGGLLQYGIPSMKMSKDVVQRRINFMIEEGIEFQTGVHIGNDKWPADKLLNDYDAIVLCVGASWPRDINIPGRNLS---GIHFALSFLEKWQRHQRDESNTEYLQVLAKDKDVIILGGGDTGVDCIATSLRQGARSVTTF------EILPTPDKSRASYNPWPEWPRIWRVDYGHEEVKLRWGKDPRHFNIMSKEFLSDENGHVAGIRTVKVEWTRDSQTEQWTMKEVPNSEDVFNCNMVLLAMGFLGPEKEIINQLK-LEVDSRTNIKTPSGKYQTSIPKVYAAGDCRRGQSLVVHAINEGRQAA 2026
The following BLAST results are available for this feature:
BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
DPYD0.000e+062.65dihydropyrimidine dehydrogenase [Source:HGNC Symbo... [more]
DPYD9.085e-7875.00dihydropyrimidine dehydrogenase [Source:HGNC Symbo... [more]
DHODH1.268e-924.24dihydroorotate dehydrogenase (quinone) [Source:HGN... [more]
DHODH1.385e-924.01dihydroorotate dehydrogenase (quinone) [Source:HGN... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dpyd-10.000e+061.13Dihydropyrimidine dehydrogenase [NADP(+)] [Source... [more]
W07E11.11.280e-1724.15pep chromosome:WBcel235:X:10084627:10104252:1 gene... [more]
W07E11.11.281e-1724.15pep chromosome:WBcel235:X:10084627:10104063:1 gene... [more]
dhod-14.528e-622.44Dihydroorotate dehydrogenase (quinone), mitochondr... [more]
dhod-14.528e-622.44Dihydroorotate dehydrogenase (quinone), mitochondr... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
su(r)0.000e+057.77gene:FBgn0086450 transcript:FBtr0071338[more]
CG96744.856e-2124.41gene:FBgn0036663 transcript:FBtr0333608[more]
CG96744.856e-2124.41gene:FBgn0036663 transcript:FBtr0305916[more]
CG96744.980e-2124.41gene:FBgn0036663 transcript:FBtr0075344[more]
CG96744.980e-2124.41gene:FBgn0036663 transcript:FBtr0075341[more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dpydb0.000e+061.00dihydropyrimidine dehydrogenase b [Source:NCBI gen... [more]
dpydb0.000e+061.63dihydropyrimidine dehydrogenase b [Source:NCBI gen... [more]
dpydb0.000e+061.75dihydropyrimidine dehydrogenase b [Source:NCBI gen... [more]
dpyda.30.000e+060.03dihydropyrimidine dehydrogenase a, tandem duplicat... [more]
dpyda.12.198e-11169.66dihydropyrimidine dehydrogenase a, tandem duplicat... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rab250.000e+063.16RAB25, member RAS oncogene family [Source:Xenbase;... [more]
rab250.000e+062.93RAB25, member RAS oncogene family [Source:Xenbase;... [more]
rab250.000e+063.00RAB25, member RAS oncogene family [Source:Xenbase;... [more]
rab250.000e+063.00RAB25, member RAS oncogene family [Source:Xenbase;... [more]
rab250.000e+062.61RAB25, member RAS oncogene family [Source:Xenbase;... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Dpyd0.000e+061.89dihydropyrimidine dehydrogenase [Source:MGI Symbol... [more]
Dpyd1.752e-2358.67dihydropyrimidine dehydrogenase [Source:MGI Symbol... [more]
Dhodh2.768e-1025.30dihydroorotate dehydrogenase [Source:MGI Symbol;Ac... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q12882|DPYD_HUMAN0.000e+062.65Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo ... [more]
sp|O89000|DPYD_RAT0.000e+062.18Dihydropyrimidine dehydrogenase [NADP(+)] OS=Rattu... [more]
sp|Q28943|DPYD_PIG0.000e+061.89Dihydropyrimidine dehydrogenase [NADP(+)] OS=Sus s... [more]
sp|Q5R895|DPYD_PONAB0.000e+062.24Dihydropyrimidine dehydrogenase [NADP(+)] OS=Pongo... [more]
sp|Q8CHR6|DPYD_MOUSE0.000e+061.89Dihydropyrimidine dehydrogenase [NADP(+)] OS=Mus m... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A088AHJ10.000e+064.93Dihydropyrimidine dehydrogenase [NADP(+)] OS=Apis ... [more]
W5MNR90.000e+063.95Dihydropyrimidine dehydrogenase [NADP(+)] OS=Lepis... [more]
A0A2A3E9Z30.000e+064.60Dihydropyrimidine dehydrogenase [NADP(+)] OS=Apis ... [more]
A0A3B1J9M60.000e+063.00Dihydropyrimidine dehydrogenase [NADP(+)] OS=Astya... [more]
A0A147BNB50.000e+063.85Dihydropyrimidine dehydrogenase [NADP(+)] OS=Ixode... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dpyda.30.000e+063.00dihydropyrimidine dehydrogenase [Source:NCBI gene;... [more]
dpyda.30.000e+062.67dihydropyrimidine dehydrogenase [Source:NCBI gene;... [more]
dpyda.30.000e+062.79dihydropyrimidine dehydrogenase [Source:NCBI gene;... [more]
dpyda.30.000e+063.10dihydropyrimidine dehydrogenase [Source:NCBI gene;... [more]
dhodh9.021e-925.00dihydroorotate dehydrogenase (quinone) [Source:NCB... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000008220.11.062e-3254.17pep scaffold:Pmarinus_7.0:GL496871:193:1202:1 gene... [more]
dhodh1.003e-626.67dihydroorotate dehydrogenase [Source:ZFIN;Acc:ZDB-... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
GLT14.112e-1726.20NAD(+)-dependent glutamate synthase (GOGAT); synth... [more]
URA15.826e-1322.13Dihydroorotate dehydrogenase; catalyzes the fourth... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO361770.000e+061.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387112.708e-1826.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO260581.805e-1525.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO354481.549e-723.89Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO274128.793e-730.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dpydb0.000e+061.60dihydropyrimidine dehydrogenase [Source:NCBI gene;... [more]
dpydb0.000e+061.49dihydropyrimidine dehydrogenase [Source:NCBI gene;... [more]
dhodh4.531e-1025.84dihydroorotate dehydrogenase (quinone) [Source:NCB... [more]
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BLAST of Dihydropyrimidine dehydrogenase [NADP( )] vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000034030.10.000e+099.30SMESG000034030.1[more]
SMESG000077776.12.091e-1622.75SMESG000077776.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004216 ID=SMED30004216|Name=Dihydropyrimidine dehydrogenase [NADP( )]|organism=Schmidtea mediterranea sexual|type=transcript|length=3292bp
ATCAGAGTATATCAGTTTTTGGCCAGTTATGTCAACAGCTACGTATACAA
AGTTGTTGATTTTGATACATGTATAAATAGTTACCAGCTTGGCATCTTAC
CGTACATTTTTTTACATCTCAATATCTTTTACACGTTTTATATCAAATTT
ATTTGCTAATGTTGAGTCGCGATCTGCCAGACATTGAAAATTTATTGTCG
CTAAATCCGAAAACATCAAAATATGCTCGGTTAGTTCCGAGCTTTTATAC
AAAATCCGAAAAATTGAAATGGAAACGAAACAGAGATAAAAATTGTTCAA
CTTGTGAATCTCTGGAAGGGAATTTTAACGATGTCAAGCCTACGACTCTA
TCTGAAAGAGGGGCCTTAAAAGAAGCCAATCGTTGTTTGAAGTGCGCAGA
CGCGCCTTGTCAAAAAAGTTGTCCAACTCAACTGGATATTAAAAGTTTCA
TCACTTCTATTGCCAATAAAAATTATTACGGAGCTGCGAAAGTTATTTTT
TCTGATAATCCATTAGGCCTCACTTGTGGCATGGTGTGCCCAACCAGTGA
CTTATGTGTAGGAAGTTGTAATCTCTACGGTACTGAAGAAGGTCCGATTA
ATATTGGAGGTCTGCAACAGTTTGCTACTGACATATTTCGACAAATGAAA
ATTCCACAGATCCGAGATCCAAATCTTCAAAATCATTTCTTGACAAGTTA
CAGGGAATCATCGATAGTATTAATTGGCTGTGGCCCGGCTTCAATTAGCT
GTGCGACATTTCTAGCTAGATTGGGGTATTCGAAAATAGAAATCTTTGAA
AAATATGATTTTTCTGGAGGTCTCAGTACTTCTGAGATTCCTGAATTTAG
ATTACCTTACAAAGTTGTCGATTTTGAATTGCAATTAATGCTCGACCTTG
GAGTAACTCTGCATTTAAATAAACCACTGTCAAAAAATATGACTGTAAAA
GATTTATTAAAATCTTATTCAGCTATTTTTCTCGGTTTTGGTCTGCCTGA
TGCGAAAAATATTGACATATTTAATGATTTAACACAAGAACAAGGATTTT
ACACTTCGAAGAAGTTTCTTCCGATTGTATCTAGATCAAGTAAGCCTGGA
ATGTGTGCTTGTAGTTATAAATTACCTCAACTACATGGTAACGTGATTGT
CCTCGGTGCGGGAGATACTGCTTTTGATTGTGCTACTTGTGCTTTAAGGT
GTGGTGCCAAACGTGTTTACATTATATTTCGAAAAGGTTTCACAACAATT
TCTCCAGTTCCAGAAGAAATGGAATTGGCAAAGGAAGAAAAATGTGAATT
CATACCCTTTATGAGTCCATATAAAGTAGAACTTAATAAAACCACCAACA
AAATTCACAGTATGGCATTCCATAAAACCTTTGAAAATGAAAATGGAGAA
ATCGAAATTGATCCAGATCAAATTTTAACACTCAAAACCGATTTTGTAAT
ATCGGCTTTTGGATCGTGTCTAACAGATCAGGAGCTAATTGAGTCTTTGA
AGCCGGTTAGGATAAATAAATATGGACTGCCAGAATGTGACAAAATGACA
TTGAAAACTAATTTAGAAAATGTATTCTGTGGTGGAGACTTGGCTGGGGT
AGCCCAAACTACCGTTGAAGCTGTCAATGATGGGAAACAAGCTGCCTGGT
ATATTCACGCTTATCTTCAATCTAAATATAATAATCCCATTGATGTTACA
AAGCCTGAATTACCTTTATTTTATACTGCAATCGACAAAGTAGATTTATC
AATTGAAATTTGTGGCATCAAATTTCCGAATCCATTTGGACTTGCCAGTG
CTCCACCAACTGGTTCAGCTTCAATGATCAGAAGAGGTTTTGAAGCTGGT
TGGGGATTCGCAGTTACTAAAACGTTCACTCTTGATAAAGATTTAGTTAC
AAATGTATCACCAAGAATTATTAGAGGTTACACATCAGGGGAACTCTATG
GACCGAATCAAGGATCGTTTTTAAATGTGGAATTATTAAGTGAGAAGAAA
GCTGAATATTGGTTAAAATGTATTCAGGAGTTAAGAAAAGATTTTCCTAA
TCAAGTACTTATTGCTAGTATTGCATGTTCCCATAACGAAGATGATTGGA
TAAAATTGTCACAAATGGTAGAAGAAGTTGGCGCGCAAGCTTTGGAACTA
AATTTATCTTGCCCTCATGGAATGTCAGAAAGAGGATTGGGACTTGCGTG
TGGTCAAATTCCTAGAATAGTAATTGAAATTTGTCAGTGGATTAAAAAAG
CAGTGAAAATTCCTTTTTTCGTAAAATTGACACCAAACATTACCAACATA
TTAGATATTGCTAGAGCTTCGTATGAAGGAGGAGCATCTGGAGTGACAGC
TACAAATACTGTATCATCTTTAATGCACATAAAAGTGAATGGCGAAGCCT
GGCCATGTGTTGGAACGGATAAGCGCACAACGTATGGTGGGATGTCAGGG
AACGCAATCCGTCCAATTTCAATGAGAGCTGTTAGCGCAATTGCTAAATC
TATTCCTGGATTTCCAATATTAGCTACCGGAGGCATAGATTCCGCTGAAA
ACGCCTTGAAATTCTTATATTGTGGTGCGAATGCCGTACAAATTTGCAGC
GCTATTCAGAATCAAGATTTTACATTAATAGACGACCTTATCACTGGTCT
AAAAGCATTATTGCACATTCAGGGTATTGAAGAACTCAGCGATTGGAATT
ACCAAAGCCCAAAAACATCAAAACATTATAAAGGTAAACCGATTATTTCA
CGCAAAAATGTTCCCTTTTTTGGGAAATTCTTAAAGGAACGAGAAAAGGA
TATCATAAATCAAAACAATGAACTTGATAAATGTTGTCCGTCTAATGTAC
CTAAGAAAAGTATTCAAAAAGTTGAAAATATAATTGGAAAATCTTTGAAT
CAAATCGGAGAATTTAAAGCTTTAAATCTCGAAGAACAGGTTGTCGCCAT
TATTGACGAAGACATGTGCATAAACTGTGGCAAATGCTACATGGCTTGCA
ATGATTCGGGCTACCAAGCCATCAAATTTGATCCAGTCACTCACATTCCA
ACCGTTACCGAAGATTGCACTGGTTGCAATTTATGTTCAGCCGTTTGTCC
AATTGTTGACTGCATAACTATGGTCCCCAAGACAATTAAACACGTAGTAA
ATCGGGGAGTGTATTGAAATTAGATGTGTTTAAAGTAAAAACCTTTTGAC
CTTACCAATTTTATTTTCATATTTGTCATAAAATTTCATTTAACAATTGA
ACTTTTCTAAAAATAAATAATTTGTACTGTTTTATAAAAAAA
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protein sequence of SMED30004216-orf-1

>SMED30004216-orf-1 ID=SMED30004216-orf-1|Name=SMED30004216-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1003bp
MLSRDLPDIENLLSLNPKTSKYARLVPSFYTKSEKLKWKRNRDKNCSTCE
SLEGNFNDVKPTTLSERGALKEANRCLKCADAPCQKSCPTQLDIKSFITS
IANKNYYGAAKVIFSDNPLGLTCGMVCPTSDLCVGSCNLYGTEEGPINIG
GLQQFATDIFRQMKIPQIRDPNLQNHFLTSYRESSIVLIGCGPASISCAT
FLARLGYSKIEIFEKYDFSGGLSTSEIPEFRLPYKVVDFELQLMLDLGVT
LHLNKPLSKNMTVKDLLKSYSAIFLGFGLPDAKNIDIFNDLTQEQGFYTS
KKFLPIVSRSSKPGMCACSYKLPQLHGNVIVLGAGDTAFDCATCALRCGA
KRVYIIFRKGFTTISPVPEEMELAKEEKCEFIPFMSPYKVELNKTTNKIH
SMAFHKTFENENGEIEIDPDQILTLKTDFVISAFGSCLTDQELIESLKPV
RINKYGLPECDKMTLKTNLENVFCGGDLAGVAQTTVEAVNDGKQAAWYIH
AYLQSKYNNPIDVTKPELPLFYTAIDKVDLSIEICGIKFPNPFGLASAPP
TGSASMIRRGFEAGWGFAVTKTFTLDKDLVTNVSPRIIRGYTSGELYGPN
QGSFLNVELLSEKKAEYWLKCIQELRKDFPNQVLIASIACSHNEDDWIKL
SQMVEEVGAQALELNLSCPHGMSERGLGLACGQIPRIVIEICQWIKKAVK
IPFFVKLTPNITNILDIARASYEGGASGVTATNTVSSLMHIKVNGEAWPC
VGTDKRTTYGGMSGNAIRPISMRAVSAIAKSIPGFPILATGGIDSAENAL
KFLYCGANAVQICSAIQNQDFTLIDDLITGLKALLHIQGIEELSDWNYQS
PKTSKHYKGKPIISRKNVPFFGKFLKEREKDIINQNNELDKCCPSNVPKK
SIQKVENIIGKSLNQIGEFKALNLEEQVVAIIDEDMCINCGKCYMACNDS
GYQAIKFDPVTHIPTVTEDCTGCNLCSAVCPIVDCITMVPKTIKHVVNRG
VY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0000166nucleotide binding
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activity
GO:0046872metal ion binding
GO:00515394 iron, 4 sulfur cluster binding
GO:0016491oxidoreductase activity
GO:0003824catalytic activity
GO:0016627oxidoreductase activity, acting on the CH-CH group of donors
GO:0004152dihydroorotate dehydrogenase activity
GO:0051536iron-sulfur cluster binding
Vocabulary: biological process
TermDefinition
GO:0006212uracil catabolic process
GO:0006214thymidine catabolic process
GO:0019483beta-alanine biosynthetic process
GO:0055114oxidation-reduction process
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0002063non-ciliated epidermis
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036188FAD/NAD-bd_sf
IPR0178964Fe4S_Fe-S-bd
IPR009051Helical_ferredxn
IPR028261DPD_II
IPR023753FAD/NAD-binding_dom
IPR013785Aldolase_TIM
IPR005720Dihydroorotate_DH
IPR0179004Fe4S_Fe_S_CS
IPR001295Dihydroorotate_DH_CS
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePRINTSPR00419ADXRDTASEcoord: 329..343
score: 53.81
coord: 185..207
score: 35.4
coord: 209..222
score: 34.18
NoneNo IPR availablePFAMPF14697Fer4_21coord: 930..988
e-value: 6.1E-24
score: 83.9
NoneNo IPR availableGENE3DG3DSA:3.30.70.20coord: 2..844
e-value: 0.0
score: 1280.2
NoneNo IPR availableGENE3DG3DSA:3.30.70.20coord: 895..1002
e-value: 4.4E-32
score: 111.9
NoneNo IPR availablePANTHERPTHR43073DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]coord: 75..1000
NoneNo IPR availablePANTHERPTHR43073:SF2DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]coord: 75..1000
NoneNo IPR availableCDDcd02940DHPD_FMNcoord: 529..831
e-value: 3.58896E-173
score: 504.896
NoneNo IPR availableSUPERFAMILYSSF51971Nucleotide-binding domaincoord: 185..435
NoneNo IPR availableSUPERFAMILYSSF548624Fe-4S ferredoxinscoord: 59..994
NoneNo IPR availableSUPERFAMILYSSF51395FMN-linked oxidoreductasescoord: 519..846
IPR005720Dihydroorotate dehydrogenase domainPFAMPF01180DHO_dhcoord: 530..835
e-value: 4.1E-36
score: 124.7
IPR005720Dihydroorotate dehydrogenase domainTIGRFAMTIGR01037TIGR01037coord: 530..843
e-value: 4.8E-52
score: 174.8
IPR009051Alpha-helical ferredoxinGENE3DG3DSA:1.10.1060.10coord: 24..178
e-value: 0.0
score: 1280.2
IPR009051Alpha-helical ferredoxinSUPERFAMILYSSF46548alpha-helical ferredoxincoord: 6..194
IPR036188FAD/NAD(P)-binding domain superfamilyGENE3DG3DSA:3.50.50.60coord: 179..529
e-value: 0.0
score: 1280.2
IPR036188FAD/NAD(P)-binding domain superfamilyGENE3DG3DSA:3.50.50.60coord: 282..436
e-value: 0.0
score: 1280.2
IPR023753FAD/NAD(P)-binding domainPFAMPF07992Pyr_redox_2coord: 185..492
e-value: 3.2E-11
score: 43.0
IPR013785Aldolase-type TIM barrelGENE3DG3DSA:3.20.20.70coord: 530..841
e-value: 0.0
score: 1280.2
IPR028261Dihydroprymidine dehydrogenase domain IIPFAMPF14691Fer4_20coord: 55..164
e-value: 2.4E-34
score: 117.5
IPR0179004Fe-4S ferredoxin, iron-sulphur binding, conserved sitePROSITEPS001984FE4S_FER_1coord: 970..981
IPR001295Dihydroorotate dehydrogenase, conserved sitePROSITEPS00912DHODEHASE_2coord: 787..807
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainPROSITEPS513794FE4S_FER_2coord: 928..960
score: 8.6
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainPROSITEPS513794FE4S_FER_2coord: 962..991
score: 9.735
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainPROSITEPS513794FE4S_FER_2coord: 67..97
score: 6.492