Rho guanine nucleotide exchange factor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004175 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607]) HSP 1 Score: 179.104 bits (453), Expect = 6.887e-47 Identity = 150/592 (25.34%), Postives = 283/592 (47.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSIKQASLTQSQG---INGGSKSLNMIESSS-NVASLSSDTSPVPNVSRSTEGKIIEHASNDG---SSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEII 1820
V A F++ + + DELSF+K D+I +T+ +GGWWEGTL+ TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + + +L+ I + ++++L+E + RVG +L++ ++ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++ED H DR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG+ V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + E V +++ + S G I S + + S +S +D+ P P + + H S+ G ++IN PK ++ L LRP PP + C ++ +++S + RK EE + ++S +++DA +L+VIE+YC S+K +L+ + + S +++
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV----LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGN------VTYMS-QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAP---LTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWS---------LSCLRPAPPLRPSAALCYKED-LSKSPKTMKKLLPKRKPERKPSD--------EEF-----ASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVL 565
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607]) HSP 1 Score: 179.104 bits (453), Expect = 6.887e-47 Identity = 150/592 (25.34%), Postives = 283/592 (47.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSIKQASLTQSQG---INGGSKSLNMIESSS-NVASLSSDTSPVPNVSRSTEGKIIEHASNDG---SSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEII 1820
V A F++ + + DELSF+K D+I +T+ +GGWWEGTL+ TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + + +L+ I + ++++L+E + RVG +L++ ++ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++ED H DR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG+ V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + E V +++ + S G I S + + S +S +D+ P P + + H S+ G ++IN PK ++ L LRP PP + C ++ +++S + RK EE + ++S +++DA +L+VIE+YC S+K +L+ + + S +++
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV----LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGN------VTYMS-QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAP---LTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWS---------LSCLRPAPPLRPSAALCYKED-LSKSPKTMKKLLPKRKPERKPSD--------EEF-----ASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVL 565
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607]) HSP 1 Score: 177.948 bits (450), Expect = 1.174e-46 Identity = 149/580 (25.69%), Postives = 276/580 (47.59%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSIKQASLTQSQG---INGGSKSLNMIESSS-NVASLSSDTSPVPNVSRSTEGKIIEHASNDG---SSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGTL+ TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + + +L+ I + ++++L+E + RVG +L++ ++ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++ED H DR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG+ V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + E V +++ + S G I S + + S +S +D+ P P + + H S+ G ++IN PK ++ L LRP PP + C ++ SPK ++ R +E + ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV----LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGN------VTYMS-QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAP---LTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWS---------LSCLRPAPPLRPSAALCYKE----------DLSKSPKTMKKLLPKRKPERKPSDEEF----ASRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 553
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607]) HSP 1 Score: 177.948 bits (450), Expect = 3.945e-46 Identity = 149/580 (25.69%), Postives = 277/580 (47.76%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSIKQASLTQSQG---INGGSKSLNMIESSS-NVASLSSDTSPVPNVSRSTEGKIIEHASNDG---SSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGTL+ TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + + +L+ I + ++++L+E + RVG +L++ ++ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++ED H DR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG+ V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + E V +++ + S G I S + + S +S +D+ P P + + H S+ G ++IN PK ++ L LRP PP + C ++ +++S + RK EE + ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV----LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGN------VTYMS-QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAP---LTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWS---------LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKPSD--------EEF-----ASRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 553
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607]) HSP 1 Score: 177.563 bits (449), Expect = 6.491e-46 Identity = 149/585 (25.47%), Postives = 275/585 (47.01%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGK---------IIEHASNDG---SSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGTL+ TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + + +L+ I + ++++L+E + RVG +L++ ++ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++ED H DR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG+ V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + E V +++ + S G N +V S + + PV S+ + K + H S+ G ++IN PK ++ L LRP PP + C ++ SPK ++ R +E + ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 139 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV----LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGN------VTYMS-QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVG--------NPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWS---------LSCLRPAPPLRPSAALCYKE----------DLSKSPKTMKKLLPKRKPERKPSDEEF----ASRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 681
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: pix-1 (PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog [Source:UniProtKB/TrEMBL;Acc:Q21430]) HSP 1 Score: 134.035 bits (336), Expect = 3.259e-33 Identity = 83/270 (30.74%), Postives = 141/270 (52.22%), Query Frame = 3
Query: 132 ALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQAD------IVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDIL 917
A F + +NDELSF+K+DIIT+TQQ +GGWWEGT + +TGWFP YVT E+ V +T +++ A ++ + EK+Y+ L L + LIP L + + + + I L + + E L+ ++ K RVG ++++ A ++ + Y+ H + L+ + ++ ++Q ++ ++ LS + RY LL+E+ER + HPDRGD+QR V+ + + C T+RK+K+ LD L
Sbjct: 13 AKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITEKDKLQRSRSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEYCTLVGNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYADNHPDAVEVLKKKQKELEKVVKSQDR--EYKELVLGLSEPLRHVERYYNLLQELERIVPANHPDRGDLQRGSAVFRETKDLCETLRKQKEAQLDFL 280
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: pix-1 (PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog [Source:UniProtKB/TrEMBL;Acc:Q21430]) HSP 1 Score: 133.65 bits (335), Expect = 2.883e-32 Identity = 83/270 (30.74%), Postives = 141/270 (52.22%), Query Frame = 3
Query: 132 ALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQAD------IVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDIL 917
A F + +NDELSF+K+DIIT+TQQ +GGWWEGT + +TGWFP YVT E+ V +T +++ A ++ + EK+Y+ L L + LIP L + + + + I L + + E L+ ++ K RVG ++++ A ++ + Y+ H + L+ + ++ ++Q ++ ++ LS + RY LL+E+ER + HPDRGD+QR V+ + + C T+RK+K+ LD L
Sbjct: 13 AKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITEKDKLQRSRSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEYCTLVGNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYADNHPDAVEVLKKKQKELEKVVKSQDR--EYKELVLGLSEPLRHVERYYNLLQELERIVPANHPDRGDLQRGSAVFRETKDLCETLRKQKEAQLDFL 280
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: sem-5 (Sex muscle abnormal protein 5 [Source:UniProtKB/Swiss-Prot;Acc:P29355]) HSP 1 Score: 60.4622 bits (145), Expect = 6.167e-10 Identity = 28/63 (44.44%), Postives = 38/63 (60.32%), Query Frame = 3
Query: 108 NTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEK 296
N + K V ALFD+ + + EL+F + D+ITL + D WWEG L+ G FPSNYV + K
Sbjct: 153 NVETKFVQALFDFNPQESGELAFKRGDVITLINKDDPNWWEGQLNNRRGIFPSNYVCPYNSNK 215
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: abi-1 (ABl Interactor homolog [Source:UniProtKB/TrEMBL;Acc:Q10929]) HSP 1 Score: 56.9954 bits (136), Expect = 3.611e-8 Identity = 25/58 (43.10%), Postives = 36/58 (62.07%), Query Frame = 3
Query: 102 MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
M N ++KV L+DY DEL+ +N I+ + ++ D W+EG LD +TG FP NYV
Sbjct: 409 MPNEYLEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDDDWYEGVLDGVTGLFPGNYV 466
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: abi-1 (ABl Interactor homolog [Source:UniProtKB/TrEMBL;Acc:Q10929]) HSP 1 Score: 56.9954 bits (136), Expect = 3.611e-8 Identity = 25/58 (43.10%), Postives = 36/58 (62.07%), Query Frame = 3
Query: 102 MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
M N ++KV L+DY DEL+ +N I+ + ++ D W+EG LD +TG FP NYV
Sbjct: 409 MPNEYLEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDDDWYEGVLDGVTGLFPGNYV 466
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: RtGEF (gene:FBgn0015803 transcript:FBtr0302106) HSP 1 Score: 188.734 bits (478), Expect = 1.326e-50 Identity = 116/382 (30.37%), Postives = 201/382 (52.62%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-----EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQV-KQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELV 1244
V A + ++ +NDEL F K D+IT+TQ+ DGGWWEGTL+ TGWFPSNYV + + E PP+ + +++ ++ + D E+ +V++L +L FL P + L++ + ++ + I+ H+ ++ ++E +RVG+L+L A + + + Y + H I L+ K ++ + E Q V LS F RL +YS +L+E+ER++E HPDRGD QR++ VY DI C+ R++K+ +L +L + GW+G+ LS LGD I ++G SV + + + V+ P L+ L+ +++ + ++ KL L + V D ++ E++ + I C P N+ V
Sbjct: 7 VQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPE---------EIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECN----DRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDII------HMG-SVAVGADHR-DRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWV 367
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: RtGEF (gene:FBgn0015803 transcript:FBtr0081356) HSP 1 Score: 189.119 bits (479), Expect = 1.923e-50 Identity = 116/382 (30.37%), Postives = 201/382 (52.62%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-----EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELV 1244
V A + ++ +NDEL F K D+IT+TQ+ DGGWWEGTL+ TGWFPSNYV + + E PP+ + +++ ++ + D E+ +V++L +L FL P + L++ + ++ + I+ H+ ++ ++E +RVG+L+L A + + + Y + H I L+ K ++ + E Q V LS F RL +YS +L+E+ER++E HPDRGD QR++ VY DI C+ R++K+ +L +L + GW+G+ LS LGD I ++G SV + + + V+ P L+ L+ +++ + ++ KL L + V D ++ E++ + I C P N+ V
Sbjct: 7 VQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPE---------EIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECN----DRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDII------HMG-SVAVGADHR-DRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWV 367
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: RtGEF (gene:FBgn0015803 transcript:FBtr0081357) HSP 1 Score: 189.119 bits (479), Expect = 1.923e-50 Identity = 116/382 (30.37%), Postives = 201/382 (52.62%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-----EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELV 1244
V A + ++ +NDEL F K D+IT+TQ+ DGGWWEGTL+ TGWFPSNYV + + E PP+ + +++ ++ + D E+ +V++L +L FL P + L++ + ++ + I+ H+ ++ ++E +RVG+L+L A + + + Y + H I L+ K ++ + E Q V LS F RL +YS +L+E+ER++E HPDRGD QR++ VY DI C+ R++K+ +L +L + GW+G+ LS LGD I ++G SV + + + V+ P L+ L+ +++ + ++ KL L + V D ++ E++ + I C P N+ V
Sbjct: 7 VQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPE---------EIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECN----DRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDII------HMG-SVAVGADHR-DRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWV 367
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: RtGEF (gene:FBgn0015803 transcript:FBtr0112885) HSP 1 Score: 190.66 bits (483), Expect = 4.895e-50 Identity = 116/382 (30.37%), Postives = 201/382 (52.62%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-----EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQV-KQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELV 1244
V A + ++ +NDEL F K D+IT+TQ+ DGGWWEGTL+ TGWFPSNYV + + E PP+ + +++ ++ + D E+ +V++L +L FL P + L++ + ++ + I+ H+ ++ ++E +RVG+L+L A + + + Y + H I L+ K ++ + E Q V LS F RL +YS +L+E+ER++E HPDRGD QR++ VY DI C+ R++K+ +L +L + GW+G+ LS LGD I ++G SV + + + V+ P L+ L+ +++ + ++ KL L + V D ++ E++ + I C P N+ V
Sbjct: 7 VQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPE---------EIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECN----DRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDII------HMG-SVAVGADHR-DRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWV 367
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: RtGEF (gene:FBgn0015803 transcript:FBtr0336748) HSP 1 Score: 190.274 bits (482), Expect = 6.708e-50 Identity = 116/382 (30.37%), Postives = 201/382 (52.62%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-----EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQV-KQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELV 1244
V A + ++ +NDEL F K D+IT+TQ+ DGGWWEGTL+ TGWFPSNYV + + E PP+ + +++ ++ + D E+ +V++L +L FL P + L++ + ++ + I+ H+ ++ ++E +RVG+L+L A + + + Y + H I L+ K ++ + E Q V LS F RL +YS +L+E+ER++E HPDRGD QR++ VY DI C+ R++K+ +L +L + GW+G+ LS LGD I ++G SV + + + V+ P L+ L+ +++ + ++ KL L + V D ++ E++ + I C P N+ V
Sbjct: 7 VQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPE---------EIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECN----DRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDII------HMG-SVAVGADHR-DRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWV 367
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef7b (Rho guanine nucleotide exchange factor (GEF) 7b [Source:ZFIN;Acc:ZDB-GENE-041212-49]) HSP 1 Score: 192.971 bits (489), Expect = 6.718e-52 Identity = 152/572 (26.57%), Postives = 270/572 (47.20%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE------EEKDGPPQSDVKTSTDSHLL-TFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDE--MKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K DII +T+Q +GGWWEG L+ TGWFPSNYV + + K G +S K ++ T+ +V +I E +Y +L ++LS +L L+ + I +L+ I + ++ +L+E S ++ R+G +L + +++ Y Y S H VN L S + M + +L+L F RL +Y LLKEMER++E HPD DIQ+++ ++ +++ +C +RK+K+ +L IL +I GW+GE + LG + +V +++ L ++ P L++L+ + + + ++ KL L +SV D + E++G E + +IC++ + + V + +Q + + S + + S S S+ SR G + H SS+ + P E KP + L LRP PP + C ++ +++S + RK EE ++++S +++DA +L+VIE+YC S+K +L+
Sbjct: 11 VKARFNFQQTNEDELSFSKGDIIQVTRQEEGGWWEGALNGKTGWFPSNYVKEIKGSDKPVSPKTGTLKSPPKAIESANFCKTYYNVVVQNILQTETEYCKELQNLLSVYLRALQPTDRLSVSDISHIMGNLEEISSFQQTLVHSLEENVKVSDSQQRIGGFFLSLLTQMRSLYVTYCSNHPSA-----VNVLTQHSEELGEFMESKGANTPGILTLTTGLSKPFLRLEKYPTLLKEMERHMEPLHPDYPDIQKSMTLFKNLSAQCQEVRKRKELELQILMESIRGWEGEGIKTLGTVLFMSQVIIQNHGAEEKNERYL----LLFPHILLMLSASPRMSGFIYQGKLPLTGMSVSKTEDSDGTKHAFEISGNMIERIQVICNNQQDLQDWVDHLHRQTKRISTSSLKPQSVPCHTLPSHPLTPSRHSE-------SRGVSGSPVYHTLPHLSSLGTPHSGMMWGPLEPPKTQKPWS--LSCLRPAPPLKPSAALCYKE-DLSKSPKNMKKLLPKRKPERKPSD--------EEF-----AVRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 550
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef7b (Rho guanine nucleotide exchange factor (GEF) 7b [Source:ZFIN;Acc:ZDB-GENE-041212-49]) HSP 1 Score: 192.586 bits (488), Expect = 5.478e-51 Identity = 152/572 (26.57%), Postives = 271/572 (47.38%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE------EEKDGPPQSDVKTSTDSHLL-TFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDE--MKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K DII +T+Q +GGWWEG L+ TGWFPSNYV + + K G +S K ++ T+ +V +I E +Y +L ++LS +L L+ + I +L+ I + ++ +L+E S ++ R+G +L + +++ Y Y S H VN L S + M + +L+L F RL +Y LLKEMER++E HPD DIQ+++ ++ +++ +C +RK+K+ +L IL +I GW+GE + LG + +V +++ L ++ P L++L+ + + + ++ KL L +SV D + E++G E + +IC++ + + V + +Q + + S + + S S S+ SR G + H SS+ + P E KP + L LRP PP + C ++ +++S + RK + EE ++++S +++DA +L+VIE+YC S+K +L+
Sbjct: 167 VKARFNFQQTNEDELSFSKGDIIQVTRQEEGGWWEGALNGKTGWFPSNYVKEIKGSDKPVSPKTGTLKSPPKAIESANFCKTYYNVVVQNILQTETEYCKELQNLLSVYLRALQPTDRLSVSDISHIMGNLEEISSFQQTLVHSLEENVKVSDSQQRIGGFFLSLLTQMRSLYVTYCSNHPSA-----VNVLTQHSEELGEFMESKGANTPGILTLTTGLSKPFLRLEKYPTLLKEMERHMEPLHPDYPDIQKSMTLFKNLSAQCQEVRKRKELELQILMESIRGWEGEGIKTLGTVLFMSQVIIQNHGAEEKNERYL----LLFPHILLMLSASPRMSGFIYQGKLPLTGMSVSKTEDSDGTKHAFEISGNMIERIQVICNNQQDLQDWVDHLHRQTKRISTSSLKPQSVPCHTLPSHPLTPSRHSE-------SRGVSGSPVYHTLPHLSSLGTPHSGMMWGPLEPPKTQKPWS--LSCLRPAPPLKPSAALCYKE-DLSKSPKNMKKLLPKRKPERKP--------SDEEF-----AVRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 706
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef7a (Rho guanine nucleotide exchange factor (GEF) 7a [Source:ZFIN;Acc:ZDB-GENE-060322-11]) HSP 1 Score: 181.03 bits (458), Expect = 6.556e-47 Identity = 149/584 (25.51%), Postives = 282/584 (48.29%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE--EEKDGPPQSDVKTS-----TDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDS--QKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGK-----------IIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DEL+F+K D+I++T+ +GGWWEG L+ TGWFPSNYV + + +++ P ++K+ T S T+ ++ +I + E +Y +L ++L+++L P L+ V I +L+ I + ++++L+++ + +VG +L++ ++ Y S H VN L V S + M + V +L+L F RL RY LLKE+ER++E+GHPDR +IQ+ + + +++ +C +RK+K+ +L IL I W+GE + LG V Y+ ++ + ++ +++ P L++L+ + + + ++ KL L ++V D + + EL+G E L +IC + + ++ + + +N +K M S ++ T P ++ S G+ + H S+ G+ + P E KP + L LRP PP + C ++ +++S + RK + EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 167 VKARFNFQQTNEDELTFSKGDLISVTRTEEGGWWEGILNGKTGWFPSNYVKEVKGSDKQVSPKSGNLKSPPKGFDTASISKTYYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSPADVSVILGNLEEISTFQQTLVQSLEDLTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPST-----VNVLTVHSEELGEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTEIQKCMTAFKNLSAQCQEVRKRKELELQILAETIRLWEGEDIKTLGS------VLYMSQAMVQNHGCEEKNERYLLLFPHVLLILSASPRMSGFIYQGKLPLSGMTVTPLEDCESHKDAFELSGSMFERLQVICYNKQDLHDWL-----------EHLNRQTKHTTMAAPSMKPLTVPCHTLPSHPLTPSRHGESRGLTVAPAYHTLPHPSSHGT----PHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKP--------SDEEF-----ALRKSTVALEEDAQILKVIEAYCTSAKTRQTLN 708
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef7a (Rho guanine nucleotide exchange factor (GEF) 7a [Source:ZFIN;Acc:ZDB-GENE-060322-11]) HSP 1 Score: 181.03 bits (458), Expect = 7.358e-47 Identity = 149/584 (25.51%), Postives = 282/584 (48.29%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE--EEKDGPPQSDVKTS-----TDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDS--QKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGK-----------IIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DEL+F+K D+I++T+ +GGWWEG L+ TGWFPSNYV + + +++ P ++K+ T S T+ ++ +I + E +Y +L ++L+++L P L+ V I +L+ I + ++++L+++ + +VG +L++ ++ Y S H VN L V S + M + V +L+L F RL RY LLKE+ER++E+GHPDR +IQ+ + + +++ +C +RK+K+ +L IL I W+GE + LG V Y+ ++ + ++ +++ P L++L+ + + + ++ KL L ++V D + + EL+G E L +IC + + ++ + + +N +K M S ++ T P ++ S G+ + H S+ G+ + P E KP + L LRP PP + C ++ +++S + RK + EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 168 VKARFNFQQTNEDELTFSKGDLISVTRTEEGGWWEGILNGKTGWFPSNYVKEVKGSDKQVSPKSGNLKSPPKGFDTASISKTYYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSPADVSVILGNLEEISTFQQTLVQSLEDLTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPST-----VNVLTVHSEELGEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTEIQKCMTAFKNLSAQCQEVRKRKELELQILAETIRLWEGEDIKTLGS------VLYMSQAMVQNHGCEEKNERYLLLFPHVLLILSASPRMSGFIYQGKLPLSGMTVTPLEDCESHKDAFELSGSMFERLQVICYNKQDLHDWL-----------EHLNRQTKHTTMAAPSMKPLTVPCHTLPSHPLTPSRHGESRGLTVAPAYHTLPHPSSHGT----PHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKP--------SDEEF-----ALRKSTVALEEDAQILKVIEAYCTSAKTRQTLN 709
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef7a (Rho guanine nucleotide exchange factor (GEF) 7a [Source:ZFIN;Acc:ZDB-GENE-060322-11]) HSP 1 Score: 167.548 bits (423), Expect = 1.635e-42 Identity = 151/586 (25.77%), Postives = 274/586 (46.76%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE--EEKDGPPQSDVKT-----STDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILL---ACTEQADIYTF-KSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGK-----------IIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DEL+F+K D+I++T+ +GGWWEG L+ TGWFPSNYV + + +++ P ++K+ T S T+ ++ +I + E +Y +L ++L+++L P L+ V I +L+ I + ++++L+++ + +VG +L++ ++ Y S H VN L V S + M + V +L+L F RL RY LLKE+ER++E+GHPDR +IQ+ + + +++ +C +RK+K+ +L IL I W+GE + LG V Y+ ++ NH V + L + + F + KL L ++V D + + EL+G E L +IC + + ++ + + +N +K M S ++ T P ++ S G+ + H S+ G+ + P E KP + L LRP PP + C ++ +++S + RK + EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 168 VKARFNFQQTNEDELTFSKGDLISVTRTEEGGWWEGILNGKTGWFPSNYVKEVKGSDKQVSPKSGNLKSPPKGFDTASISKTYYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSPADVSVILGNLEEISTFQQTLVQSLEDLTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPST-----VNVLTVHSEELGEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTEIQKCMTAFKNLSAQCQEVRKRKELELQILAETIRLWEGEDIKTLGS------VLYMSQAM------VQNHGCEVGQHHIYLFDQNQTIKSKRLLCFSQGKLPLSGMTVTPLEDCESHKNAFELSGSMFERLQVICYNKQDLHDWL-----------EHLNRQTKHTTMAAPSMKPLTVPCHTLPSHPLTPSRHGESRGLTVAPAYHTLPHPSSHGTP----HSTMMWGPLEPPKTQKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKP--------SDEEF-----ALRKSTVALEEDAQILKVIEAYCTSAKTRQTLN 705
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:100145259]) HSP 1 Score: 177.948 bits (450), Expect = 2.700e-46 Identity = 152/572 (26.57%), Postives = 262/572 (45.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-EKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK D+I +T+ +GGWWEGT TGWFPSNYV + + EK P+S S T + ++ +I D E +Y +L +LS +L L+ + + +L+ I + ++++L+E + RVG ++ + ++ Y Y + H VN L S + M + +L L F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I GW+GE + LG I +V S++ +++ P L++L+ + + + ++ K+ L + V D N + E+ G + I C++ + E V + KQ T S+ S+ + SS S + + + H S+ G+ +S P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 11 VRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPKSTTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSA-----VNVLTQHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQC----AGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHKQTKYTSLINPTIKPHSVPCHTLPSHPVTPSSKHSDCKLMPLTPAYHTLPHLSHHGT----PHSTISWSPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKPSD--------EEF-----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 553
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:100145259]) HSP 1 Score: 178.718 bits (452), Expect = 3.643e-46 Identity = 152/572 (26.57%), Postives = 262/572 (45.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-EKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK D+I +T+ +GGWWEGT TGWFPSNYV + + EK P+S S T + ++ +I D E +Y +L +LS +L L+ + + +L+ I + ++++L+E + RVG ++ + ++ Y Y + H VN L S + M + +L L F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I GW+GE + LG I +V S++ +++ P L++L+ + + + ++ K+ L + V D N + E+ G + I C++ + E V + KQ T S+ S+ + SS S + + + H S+ G+ +S P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 149 VRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPKSTTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSA-----VNVLTQHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQC----AGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHKQTKYTSLINPTIKPHSVPCHTLPSHPVTPSSKHSDCKLMPLTPAYHTLPHLSHHGT----PHSTISWSPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKPSD--------EEF-----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 691
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:100145259]) HSP 1 Score: 178.718 bits (452), Expect = 4.140e-46 Identity = 152/572 (26.57%), Postives = 262/572 (45.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-EKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK D+I +T+ +GGWWEGT TGWFPSNYV + + EK P+S S T + ++ +I D E +Y +L +LS +L L+ + + +L+ I + ++++L+E + RVG ++ + ++ Y Y + H VN L S + M + +L L F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I GW+GE + LG I +V S++ +++ P L++L+ + + + ++ K+ L + V D N + E+ G + I C++ + E V + KQ T S+ S+ + SS S + + + H S+ G+ +S P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 184 VRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPKSTTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSA-----VNVLTQHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQC----AGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHKQTKYTSLINPTIKPHSVPCHTLPSHPVTPSSKHSDCKLMPLTPAYHTLPHLSHHGT----PHSTISWSPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKPSD--------EEF-----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 726
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:100145259]) HSP 1 Score: 178.333 bits (451), Expect = 4.490e-46 Identity = 152/572 (26.57%), Postives = 262/572 (45.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-EKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK D+I +T+ +GGWWEGT TGWFPSNYV + + EK P+S S T + ++ +I D E +Y +L +LS +L L+ + + +L+ I + ++++L+E + RVG ++ + ++ Y Y + H VN L S + M + +L L F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I GW+GE + LG I +V S++ +++ P L++L+ + + + ++ K+ L + V D N + E+ G + I C++ + E V + KQ T S+ S+ + SS S + + + H S+ G+ +S P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 167 VRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPKSTTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSA-----VNVLTQHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQC----AGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHKQTKYTSLINPTIKPHSVPCHTLPSHPVTPSSKHSDCKLMPLTPAYHTLPHLSHHGT----PHSTISWSPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKPSD--------EEF-----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 709
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: ARHGEF7 (Rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:100145259]) HSP 1 Score: 177.948 bits (450), Expect = 4.495e-46 Identity = 152/572 (26.57%), Postives = 262/572 (45.80%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-EKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK D+I +T+ +GGWWEGT TGWFPSNYV + + EK P+S S T + ++ +I D E +Y +L +LS +L L+ + + +L+ I + ++++L+E + RVG ++ + ++ Y Y + H VN L S + M + +L L F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I GW+GE + LG I +V S++ +++ P L++L+ + + + ++ K+ L + V D N + E+ G + I C++ + E V + KQ T S+ S+ + SS S + + + H S+ G+ +S P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 139 VRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPKSTTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSA-----VNVLTQHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQC----AGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHKQTKYTSLINPTIKPHSVPCHTLPSHPVTPSSKHSDCKLMPLTPAYHTLPHLSHHGT----PHSTISWSPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKTMKKLLPKRKPERKPSD--------EEF-----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 681
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef7 (Rho guanine nucleotide exchange factor (GEF7) [Source:MGI Symbol;Acc:MGI:1860493]) HSP 1 Score: 166.777 bits (421), Expect = 8.137e-43 Identity = 151/582 (25.95%), Postives = 272/582 (46.74%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEII 1820
V A F++ + + DELSF+K D+I +T+ +GGWWEGT + TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + +L+ I + ++++L+E + + RVG +L + ++ Y Y + H + L + + E + V LS F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C S + +E V + KQ +T S+ S+ + SS + V+ + + H S+ G+ +S P E KP + L LRP PP + C ++ S + PK +K + A+ ++S +++DA +L+VIE+YC S+K +L+ + + S +++
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGS------VTYMS-QVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGT----PHTTISWGPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKED--LSKSPKTMKKLLPKRKPERKPSDEEFAV------------RKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVL 565
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef7 (Rho guanine nucleotide exchange factor (GEF7) [Source:MGI Symbol;Acc:MGI:1860493]) HSP 1 Score: 165.622 bits (418), Expect = 4.745e-42 Identity = 151/570 (26.49%), Postives = 266/570 (46.67%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGT + TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + +L+ I + ++++L+E + + RVG +L + ++ Y Y + H + L + + E + V LS F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C S + +E V + KQ +T S+ S+ + SS + V+ + + H S+ G+ +S P E KP + L LRP PP + C ++ SPK ++ R +E V ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGS------VTYMS-QVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGT----PHTTISWGPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKTMKKLLPKRKPERKPSDEEFAV----RKSTAALEEDAQILKVIEAYCTSAKTRQTLN 710
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef7 (Rho guanine nucleotide exchange factor (GEF7) [Source:MGI Symbol;Acc:MGI:1860493]) HSP 1 Score: 164.466 bits (415), Expect = 6.712e-42 Identity = 151/570 (26.49%), Postives = 266/570 (46.67%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGT + TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + +L+ I + ++++L+E + + RVG +L + ++ Y Y + H + L + + E + V LS F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C S + +E V + KQ +T S+ S+ + SS + V+ + + H S+ G+ +S P E KP + L LRP PP + C ++ SPK ++ R +E V ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGS------VTYMS-QVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGT----PHTTISWGPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKTMKKLLPKRKPERKPSDEEFAV----RKSTAALEEDAQILKVIEAYCTSAKTRQTLN 553
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:1920591]) HSP 1 Score: 150.599 bits (379), Expect = 6.294e-40 Identity = 92/297 (30.98%), Postives = 154/297 (51.85%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQR------MLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKV 989
V A F++ + + DELS K DII +T+ +GGWWEGTL+ TGWFPSNYV + + E+ P++ T + ++ +I D EK+Y +L +L T+L P +L+ + + + + + + + +AL+E N+++VG L++ Y Y + H + L + ++ ENQ ++ S LS F RL +Y LL+E+ER++ED HPD DI +AI+ + + +C +RK+K +L IL I W+G+ + LG+ I +V
Sbjct: 11 VKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKPSERPLSPKAIKGFDTAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEFTCLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHSDDLERFMENQGASSPGILILTTS-----LSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIIAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGDDIKTLGNVIFMSQV 302
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:1920591]) HSP 1 Score: 153.295 bits (386), Expect = 5.220e-38 Identity = 100/363 (27.55%), Postives = 179/363 (49.31%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQR------MLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSV----YINSDECNIEM 1175
V A F++ + + DELS K DII +T+ +GGWWEGTL+ TGWFPSNYV + + E+ P++ T + ++ +I D EK+Y +L +L T+L P +L+ + + + + + + + +AL+E N+++VG L++ Y Y + H + L + ++ ENQ ++ S LS F RL +Y LL+E+ER++ED HPD DI +AI+ + + +C +RK+K +L IL I W+G+ + LG+ I +V + ++ ++ LI+L+ + + + ++ K+ + + V I +C E+
Sbjct: 188 VKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKPSERPLSPKAIKGFDTAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEFTCLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHSDDLERFMENQGASSPGILILTTS-----LSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIIAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHGAC----EEKEERYFLLFSSVLIMLSASPRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMFEI 541
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q14155|ARHG7_HUMAN (Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2) HSP 1 Score: 177.563 bits (449), Expect = 5.200e-45 Identity = 149/585 (25.47%), Postives = 275/585 (47.01%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGK---------IIEHASNDG---SSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGTL+ TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + + +L+ I + ++++L+E + RVG +L++ ++ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++ED H DR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG+ V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + E V +++ + S G N +V S + + PV S+ + K + H S+ G ++IN PK ++ L LRP PP + C ++ SPK ++ R +E + ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 189 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV----LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGN------VTYMS-QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVG--------NPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWS---------LSCLRPAPPLRPSAALCYKE----------DLSKSPKTMKKLLPKRKPERKPSDEEF----ASRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 731
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|O55043|ARHG7_RAT (Rho guanine nucleotide exchange factor 7 OS=Rattus norvegicus OX=10116 GN=Arhgef7 PE=1 SV=1) HSP 1 Score: 166.007 bits (419), Expect = 1.063e-41 Identity = 150/582 (25.77%), Postives = 275/582 (47.25%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEII 1820
V A F++ + + DELSF+K D+I +T+ +GGWWEGT + TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + +L+ I + ++++L+E + + RVG +L + ++ Y Y + H + L + + E + V LS F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C++ + +E V + +Q +T S+ S+ + SS + V+ + + H S+ G+ +S P E KP + L LRP PP + C ++ ++RS + RK EE ++++S +++DA +L+VIE+YC S+K +L+ + + S +++
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGS------VTYMS-QVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGT----PHTTISWGPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKED-LSRSPKTMKKLLPKRKPERKPSD--------EEF-----AVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVL 565
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q9ES28|ARHG7_MOUSE (Rho guanine nucleotide exchange factor 7 OS=Mus musculus OX=10090 GN=Arhgef7 PE=1 SV=2) HSP 1 Score: 165.236 bits (417), Expect = 8.032e-41 Identity = 151/570 (26.49%), Postives = 266/570 (46.67%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT------FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-LSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPID---SQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLI---CDSPETRNELVLSI-KQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSF+K D+I +T+ +GGWWEGT + TGWFPSNYV + + EK P+S S T + ++ +I + E +Y +L +LST+L P L+ + +L+ I + ++++L+E + + RVG +L + ++ Y Y + H + L + + E + V LS F RL +Y LLKE+ER++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL I W+G+ + LG V+Y+ V I S++ +++ P L++L+ + + + ++ KL +++ D N E++G + I C S + +E V + KQ +T S+ S+ + SS + V+ + + H S+ G+ +S P E KP + L LRP PP + C ++ SPK ++ R +E V ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGS------VTYMS-QVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGT----PHTTISWGPLEPPKTPKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKTMKKLLPKRKPERKPSDEEFAV----RKSTAALEEDAQILKVIEAYCTSAKTRQTLN 710
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5ZLR6|ARHG6_CHICK (Rho guanine nucleotide exchange factor 6 OS=Gallus gallus OX=9031 GN=ARHGEF6 PE=2 SV=1) HSP 1 Score: 159.458 bits (402), Expect = 3.285e-39 Identity = 143/563 (25.40%), Postives = 254/563 (45.12%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLT--FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPP--AAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSL 1781
V A F++ + + DELS NK DII +T+ +GGWWEGTL+ TGWFPSNYV + + D P +S LT + ++ +I + E+ Y +L +L T+L P L+ + + +++ I + + +AL+++ N+ RVG ++++ ++ Y Y S+V + ++ E+ K N +L + LS F RL +Y LL+E+ER++E+ H D D+ +AI + + +C +RK+K +L IL +I W+GE + +G+ I +V S++ ++ L++L+ + + + ++ +L L +++ D E E+ G + I S T +L L Q + G+ + S S S+ S GS+ + P E + KP + L LRP PP +A L + + + SS + +RK E + A + E V+R +S +++DA +L+VIE+YC + +L
Sbjct: 157 VKARFNFKQTNEDELSVNKGDIIYVTRVEEGGWWEGTLNGKTGWFPSNYVREI-KSTDKPLSPKALKGLESTQLTKNYYPVVLQNILETERDYAKELQSLLGTYLRPLQSYDKLSAVDIASLLGNVEEISAFQQTLNQALEDVAKLPENQQRVGGCFMNLMAQFRSLYLTYCANHPSAVSVLTQHSDELEKFMESQGAANPGILI----LTTSLSKPFLRLDKYVTLLQELERHMEEAHADHEDVLKAITSFKSLVSQCQELRKRKQLELQILSESIQRWEGEDIKTMGNIIYMSQVMVQSGG----SEEKEERYFLLFSNVLLMLSASPRMSGFIYQGRLPLTGMTLTKLEDAEGNEHMFEIAGNMMERITVSCSTSQDL-----HEWLEHLQRLTKGT-----CNTVSKTQSWSAH-------------------STFGSTGQIRG------PLEPPKILKPWS--LSCLRPAPPLRPSAALSYKERMSYILKDSSKSPKTMKKFLPKRKTE---RKASDEEFVIR------KSTAALEEDAQILKVIEAYCTGAGFQQAL 664
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q8K4I3|ARHG6_MOUSE (Rho guanine nucleotide exchange factor 6 OS=Mus musculus OX=10090 GN=Arhgef6 PE=1 SV=1) HSP 1 Score: 152.91 bits (385), Expect = 5.371e-37 Identity = 100/363 (27.55%), Postives = 179/363 (49.31%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQR------MLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSV----YINSDECNIEM 1175
V A F++ + + DELS K DII +T+ +GGWWEGTL+ TGWFPSNYV + + E+ P++ T + ++ +I D EK+Y +L +L T+L P +L+ + + + + + + + +AL+E N+++VG L++ Y Y + H + L + ++ ENQ ++ S LS F RL +Y LL+E+ER++ED HPD DI +AI+ + + +C +RK+K +L IL I W+G+ + LG+ I +V + ++ ++ LI+L+ + + + ++ K+ + + V I +C E+
Sbjct: 164 VKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKPSERPLSPKAIKGFDTAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEFTCLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHSDDLERFMENQGASSPGILILTTS-----LSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIIAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHGACEEKEERYF----LLFSSVLIMLSASPRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMFEI 517
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A183APP5 (Uncharacterized protein OS=Echinostoma caproni OX=27848 PE=4 SV=1) HSP 1 Score: 273.478 bits (698), Expect = 8.588e-80 Identity = 148/340 (43.53%), Postives = 214/340 (62.94%), Query Frame = 3
Query: 168 LSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDS--HLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLI---PSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNK-NRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKV---------SYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSV 1142
LSF + D I +++Q+DGGWWEG+L+ + GWFPSNYV G SD +++ D HL TFQ +IV HI +GE + V++L+ ++S L+ P +P L+ K + D L I LH+ + ALD+MK +N+ RVG+L+LD AS I +YS +HL+V+ ++ N A++ H + + F S+ KQ LSLVFDRL RY LLLKEMERYLE+ H DR DIQRA+ VY +I E+C +RK K+ D+DIL + I GW+G + +LGDPILT++V + P+ +DS + V+V+ P C++LLA +Q D+Y F K+ L L+V
Sbjct: 1 LSFKRGDTIVVSRQVDGGWWEGSLNGVVGWFPSNYVIPVP--PSGAAVSDRRSADDQFLHLRTFQDEIVQHILEGEVRQVNELTQLVSGVLVHLEPFAHLPFLS--KASHMKDLLNQAIHLHQTLAGALDQMKQSNEPKRVGKLFLDFASTINAIGCDYSKIHLYVVTGIDKNADAIERHMSSCGVKFQPSRCKQQLSLVFDRLGRYPLLLKEMERYLENPHMDRADIQRAMSVYGEITERCAILRKFKEYDIDILLSTINGWQGMSIEKLGDPILTLRVLLNTIEYDATATQPAT-VDSVRGQLSVLVIFPSCVLLLARNKQMDVYEFTKKVPLNCLTV 335
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A3P8HKR4 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS8930 PE=4 SV=1) HSP 1 Score: 273.092 bits (697), Expect = 1.187e-79 Identity = 147/340 (43.24%), Postives = 214/340 (62.94%), Query Frame = 3
Query: 168 LSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDS--HLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLI---PSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNK-NRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKV---------SYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSV 1142
+SF + D I +++Q+DGGWWEG+L+ + GWFPSNYV G SD +++ D HL TFQ +IV HI +GE + V++L+ ++S L+ P +P L+ K + D L I LH+ + ALD+MK +N+ RVG+L+LD AS I +YS +HL+V+ ++ N A++ H + + F S+ KQ LSLVFDRL RY LLLKEMERYLE+ H DR DIQRA+ VY +I E+C +RK K+ D+DIL + I GW+G + +LGDPILT++V + P+ +DS + V+V+ P C++LLA +Q D+Y F K+ L L+V
Sbjct: 1 MSFKRGDTIVVSRQVDGGWWEGSLNGVVGWFPSNYVIPVP--PSGAAVSDRRSADDQFLHLRTFQDEIVQHILEGEVRQVNELTQLVSGVLVHLEPFAHLPFLS--KASHMKDLLNQAIHLHQTLAGALDQMKQSNEPKRVGKLFLDFASTINAIGCDYSKIHLYVVTGIDKNADAIERHMSSCGVKFQPSRCKQQLSLVFDRLGRYPLLLKEMERYLENPHMDRADIQRAMSVYGEITERCAILRKFKEYDIDILLSTINGWQGMSIEKLGDPILTLRVLLNTIEYDATATQPAT-VDSVRGQLSVLVIFPSCVLLLARNKQMDVYEFTKKVPLNCLTV 335
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A4E0RJN3 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_001244 PE=4 SV=1) HSP 1 Score: 278.485 bits (711), Expect = 1.832e-77 Identity = 155/356 (43.54%), Postives = 216/356 (60.67%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQS---DVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLI---PSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMK-STNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIK-----VSYIGPSVPIDSQKA-----LNHVVVVMPICLILLACTEQADIYTFKSKLALENLSV 1142
V A++DYIR+H DELSF + + I +++Q+DGGWWEG+L+ + GWFPSNYV P S D + S D H IV HI +GE + VS+L+ ++S L+ P + +P LN KV + + L I LH+ + ALD+MK S+ RVG+L+LD AS I +YS +HL+V+ ++ N V+ H + F S+ KQ LSLVFDRL RY LLLKEMERYLE+ H DR DIQRA+ VY +I E+C +RK K+ D+DIL + I GW+G + +LGDPILT++ V Y P + A V+V+ P C++LLA +Q D+Y F K+ L L+V
Sbjct: 8 VQAVYDYIRKHTDELSFKRGETILVSRQMDGGWWEGSLNGVVGWFPSNYVVPV------PSTSIIVDDRRSVDDH-----RQIVQHILEGEVRQVSELAQLISGVLVHLEPFIHLPFLN--KVGHMKELLNQAIHLHQTLASALDQMKRSSEPKRVGKLFLDFASTINAIGCDYSKIHLYVVTGIDKNADIVERHMSTCGVKFQPSRWKQQLSLVFDRLGRYPLLLKEMERYLENPHVDRTDIQRAMSVYGEITERCAILRKFKEYDIDILLSTINGWQGMSIDKLGDPILTLRVLLTAVEYESPGTANSTTDANLVGGQLSVLVIFPTCVLLLARNKQMDVYEFTKKVPLSCLTV 350
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A4Z2D350 (Rho guanine nucleotide exchange factor 7 isoform 6 OS=Schistosoma japonicum OX=6182 GN=EWB00_005058 PE=4 SV=1) HSP 1 Score: 267.7 bits (683), Expect = 2.381e-74 Identity = 146/357 (40.90%), Postives = 211/357 (59.10%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLI---PSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNR-VGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHV--------------VVVMPICLILLACTEQADIYTFKSKLALENLSV 1142
V AL+DY RRH DELSF K D++ +++Q++GGWWEG+LD GWFPSNYVT + D + S HL +FQ +I+ H+ +GE + VS+LS +LS F+I P L + LN K + D L I +H+ + AL EMK T+ + +GRL+LD A I +YS ++L VI LE + + H + + KQ L LVF+RL RY L LKEMERYLE+ H DR DI RAI +Y +I E+C +RK K+ D+++L + I GW G + QLGDPILT++V + + L+ + +V+ P C++LLA T Q+++Y + +K+ L NL+V
Sbjct: 8 VCALYDYNRRHTDELSFKKGDVLQVSKQLEGGWWEGSLDGFVGWFPSNYVT-YTTSADIKNNTTTDESLLMHLQSFQNEIIQHVLEGELRQVSELSQLLSIFMIDLEPLLHLSFLN--KFIHLRDILSQTISIHQHLASALSEMKRTHGPKCMGRLFLDFAPAINAVSCDYSKIYLHVITGLEEHIADITKHMASFNINLHLPDCKQQLMLVFERLGRYPLFLKEMERYLEELHIDRADILRAIHIYGEITERCAILRKFKEYDINVLLSVINGWHGPPIQQLGDPILTLRVLLVNIQIDQSHVALLDFICTDDLMAIKTQLSLLVIFPTCVLLLARTNQSNVYDYTTKVPLNNLTV 361
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A4Z2D2V3 (Rho guanine nucleotide exchange factor 7 isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_005058 PE=4 SV=1) HSP 1 Score: 267.314 bits (682), Expect = 5.547e-74 Identity = 146/357 (40.90%), Postives = 211/357 (59.10%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLI---PSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNR-VGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHV--------------VVVMPICLILLACTEQADIYTFKSKLALENLSV 1142
V AL+DY RRH DELSF K D++ +++Q++GGWWEG+LD GWFPSNYVT + D + S HL +FQ +I+ H+ +GE + VS+LS +LS F+I P L + LN K + D L I +H+ + AL EMK T+ + +GRL+LD A I +YS ++L VI LE + + H + + KQ L LVF+RL RY L LKEMERYLE+ H DR DI RAI +Y +I E+C +RK K+ D+++L + I GW G + QLGDPILT++V + + L+ + +V+ P C++LLA T Q+++Y + +K+ L NL+V
Sbjct: 8 VCALYDYNRRHTDELSFKKGDVLQVSKQLEGGWWEGSLDGFVGWFPSNYVT-YTTSADIKNNTTTDESLLMHLQSFQNEIIQHVLEGELRQVSELSQLLSIFMIDLEPLLHLSFLN--KFIHLRDILSQTISIHQHLASALSEMKRTHGPKCMGRLFLDFAPAINAVSCDYSKIYLHVITGLEEHIADITKHMASFNINLHLPDCKQQLMLVFERLGRYPLFLKEMERYLEELHIDRADILRAIHIYGEITERCAILRKFKEYDINVLLSVINGWHGPPIQQLGDPILTLRVLLVNIQIDQSHVALLDFICTDDLMAIKTQLSLLVIFPTCVLLLARTNQSNVYDYTTKVPLNNLTV 361
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef7b (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:103036596]) HSP 1 Score: 193.356 bits (490), Expect = 1.587e-51 Identity = 157/575 (27.30%), Postives = 264/575 (45.91%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTS------TDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNV-------SRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DEL FNK DII +T+Q DGGWWEGT + TGWFPSNYV + + +K P+S + S T++ T+ +V +I E +Y +L +LST+L L + I +L+ I + ++++L+E N+ RVG +L + +++ Y Y S H + L + + E++ + V +L+L F RL +Y LL+E++R++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL + W+GE + LG I +V S++ +++ P L++L+ + + + ++ KL L + V D N S + + +IC++ +Q L + + +K + SS S+ T P V SR T G H SS + P E KP + L LRP PP P S SPK+ ++ R EE V ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 114 VKARFNFQQNNEDELCFNKGDIIQVTRQEDGGWWEGTFNGRTGWFPSNYVKEVKGSDKPISPKSGTQKSPPKGFETNAVTKTYYNLVVQNILQTETEYCKELQTLLSTYLRLLQPTDRLTVADIAHILGNLEEISSFQQTLVQSLEECTKLPENQQRVGGFFLSLMTQMKSLYVAYCSNHPHAVSVLTQHSEELGEFMESK-----GASVPGILTLTTNLSKPFMRLDKYPTLLQELDRHMEDCHPDRPDIQKSLPTFKNLSAQCQEVRKRKELELQILTDPVRNWEGEGIKTLGSVIYMSQVLLQNHG----SEEKNERYLLLFPHVLLVLSASPRMSCFIYQGKLPLTGMMVTKCEDARNTFEISGTMIDRIQVICNN-----------QQDLLEWVEHLTRQTKRTSSCTSSLKPQSVPCHTLPSHPVTPSRHSESRGTSGTPAYHTLPHPSSHGTPHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLK----------PSAALSYKEDLSKSPKSMKKLLHKRKPERKPSEEEFAV----RKSTAALEEDAQILKVIEAYCTSAKTRQTLN 652
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef7b (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:103036596]) HSP 1 Score: 193.356 bits (490), Expect = 3.966e-51 Identity = 154/568 (27.11%), Postives = 264/568 (46.48%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTS------TDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DEL FNK DII +T+Q DGGWWEGT + TGWFPSNYV + + +K P+S + S T++ T+ +V +I E +Y +L +LST+L L + I +L+ I + ++++L+E N+ RVG +L + +++ Y Y S H + L + + E++ + V +L+L F RL +Y LL+E++R++ED HPDR DIQ+++ + +++ +C +RK+K+ +L IL + W+GE + LG I +V S++ +++ P L++L+ + + + ++ KL L + V D N S + + +IC++ + E V + + Q++ + + SL + T + SR T G H SS + P E KP + L LRP PP P S SPK+ ++ R EE V ++S +++DA +L+VIE+YC S+K +L+
Sbjct: 167 VKARFNFQQNNEDELCFNKGDIIQVTRQEDGGWWEGTFNGRTGWFPSNYVKEVKGSDKPISPKSGTQKSPPKGFETNAVTKTYYNLVVQNILQTETEYCKELQTLLSTYLRLLQPTDRLTVADIAHILGNLEEISSFQQTLVQSLEECTKLPENQQRVGGFFLSLMTQMKSLYVAYCSNHPHAVSVLTQHSEELGEFMESKG-----ASVPGILTLTTNLSKPFMRLDKYPTLLQELDRHMEDCHPDRPDIQKSLPTFKNLSAQCQEVRKRKELELQILTDPVRNWEGEGIKTLGSVIYMSQVLLQNHG----SEEKNERYLLLFPHVLLVLSASPRMSCFIYQGKLPLTGMMVTKCEDARNTFEISGTMIDRIQVICNNQQDLLEWVEHLTR----QTKRTSSCTSSLKPQSVPCHTLPSHPVTPSRHSESRGTSGTPAYHTLPHPSSHGTPHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLK----------PSAALSYKEDLSKSPKSMKKLLHKRKPERKPSEEEFAV----RKSTAALEEDAQILKVIEAYCTSAKTRQTLN 705
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef7a (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:103045992]) HSP 1 Score: 176.407 bits (446), Expect = 5.887e-46 Identity = 146/577 (25.30%), Postives = 272/577 (47.14%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTST----DSHLL--TFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSP----VPNVSRSTEGKIIE---HASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK DII +T+ +GGWWEG+++ TGWFPSNYV + + +K P+S S D+ L T+ ++ +I + E +Y L +LS +L P L+ I +L+ I + ++++L++ + +VG +L++ K+ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++E+GHPDR +IQ+ + + +++ +C +RK+K+ +L IL ++ W+GE + LG + + +++ L ++ P L++L+ + + + ++ KL L ++V D + + EL+G E L ++C + + + + + + +N +K M S ++ T P P+ + G + H SS + P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 11 VKARFNFQQTNEDELSFNKGDIINVTRTEEGGWWEGSINGKTGWFPSNYVREVKGSDKQVSPKSGTLKSPPKGFDTTALSKTYYNLVLQNILETETEYSKDLQSLLSNYLRPLQNTEKLSSADASVILGNLEEISTFQQTLVQSLEDCTKLPELQQKVGGFFLNLMPKMRALYLGYCSNHPSAVNILTDHSEELGEFMEGRGASSPGILI----LTTGLSKPFMRLDKYPTLLKELERHMEEGHPDRMEIQKCMTAFKNLSGQCQEVRKRKELELQILTESVRLWEGEDIKTLGSVLFMSQAMVQNHGCEERNERYL----MLFPHVLLILSASPRMSGFIYQGKLPLSCMTVTPLEDCESYKNAFELSGSMFERLKVVCFNKQDQQDWL-----------EHLNRQTKHTTMTAPSMKPLTVPCHTLPSHPLTPSRHAESRGLTVAPAYHTLPHPSSHGAPHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKSMKKLLPKRKPERKPSD--------EEF-----ALRKSTVALEEDAQILKVIEAYCTSAKTRQTLN 552
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef7a (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:103045992]) HSP 1 Score: 176.792 bits (447), Expect = 1.042e-45 Identity = 148/589 (25.13%), Postives = 277/589 (47.03%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTST----DSHLL--TFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSP----VPNVSRSTEGKIIE---HASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEII 1820
V A F++ + + DELSFNK DII +T+ +GGWWEG+++ TGWFPSNYV + + +K P+S S D+ L T+ ++ +I + E +Y L +LS +L P L+ I +L+ I + ++++L++ + +VG +L++ K+ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++E+GHPDR +IQ+ + + +++ +C +RK+K+ +L IL ++ W+GE + LG + + +++ L ++ P L++L+ + + + ++ KL L ++V D + + EL+G E L ++C + + + + + + +N +K M S ++ T P P+ + G + H SS + P E KP + L LRP PP + C ++ +++S + RK EE +L++S +++DA +L+VIE+YC S+K +L+ + R + +I
Sbjct: 154 VKARFNFQQTNEDELSFNKGDIINVTRTEEGGWWEGSINGKTGWFPSNYVREVKGSDKQVSPKSGTLKSPPKGFDTTALSKTYYNLVLQNILETETEYSKDLQSLLSNYLRPLQNTEKLSSADASVILGNLEEISTFQQTLVQSLEDCTKLPELQQKVGGFFLNLMPKMRALYLGYCSNHPSAVNILTDHSEELGEFMEGRGASSPGILI----LTTGLSKPFMRLDKYPTLLKELERHMEEGHPDRMEIQKCMTAFKNLSGQCQEVRKRKELELQILTESVRLWEGEDIKTLGSVLFMSQAMVQNHGCEERNERYL----MLFPHVLLILSASPRMSGFIYQGKLPLSCMTVTPLEDCESYKNAFELSGSMFERLKVVCFNKQDQQDWL-----------EHLNRQTKHTTMTAPSMKPLTVPCHTLPSHPLTPSRHAESRGLTVAPAYHTLPHPSSHGAPHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLRPSAALCYKE-DLSKSPKSMKKLLPKRKPERKPSD--------EEF-----ALRKSTVALEEDAQILKVIEAYCTSAKTRQTLNSRQRRDTAPALI 707
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef7a (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:103045992]) HSP 1 Score: 176.407 bits (446), Expect = 1.448e-45 Identity = 145/577 (25.13%), Postives = 271/577 (46.97%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTS------TDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTN--KNRVGRLYLDMASKITESYYEY-----SSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSP----VPNVSRSTEGKIIE---HASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DELSFNK DII +T+ +GGWWEG+++ TGWFPSNYV + + +K P+S S T + T+ ++ +I + E +Y L +LS +L P L+ I +L+ I + ++++L++ + +VG +L++ K+ Y Y S+V++ ++ E+ + + +L + LS F RL +Y LLKE+ER++E+GHPDR +IQ+ + + +++ +C +RK+K+ +L IL ++ W+GE + LG + + +++ L ++ P L++L+ + + + ++ KL L ++V D + + EL+G E L ++C + + + + + + +N +K M S ++ T P P+ + G + H SS + P E KP + L LRP PP + C ++ SPK+ ++ R +E +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 196 VKARFNFQQTNEDELSFNKGDIINVTRTEEGGWWEGSINGKTGWFPSNYVREVKGSDKQVSPKSGTLKSPPKGFDTTALSKTYYNLVLQNILETETEYSKDLQSLLSNYLRPLQNTEKLSSADASVILGNLEEISTFQQTLVQSLEDCTKLPELQQKVGGFFLNLMPKMRALYLGYCSNHPSAVNILTDHSEELGEFMEGRGASSPGILI----LTTGLSKPFMRLDKYPTLLKELERHMEEGHPDRMEIQKCMTAFKNLSGQCQEVRKRKELELQILTESVRLWEGEDIKTLGSVLFMSQAMVQNHGCEERNERYL----MLFPHVLLILSASPRMSGFIYQGKLPLSCMTVTPLEDCESYKNAFELSGSMFERLKVVCFNKQDQQDWL-----------EHLNRQTKHTTMTAPSMKPLTVPCHTLPSHPLTPSRHAESRGLTVAPAYHTLPHPSSHGAPHSTMMWGPLEPPKTQKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKSMKKLLPKRKPERKPSDEEF----ALRKSTVALEEDAQILKVIEAYCTSAKTRQTLN 737
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009021.1 (pep scaffold:Pmarinus_7.0:GL482604:596:7954:-1 gene:ENSPMAG00000008160.1 transcript:ENSPMAT00000009021.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 156.377 bits (394), Expect = 1.137e-42 Identity = 91/287 (31.71%), Postives = 158/287 (55.05%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHLLT---FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLF-DWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLG 965
V A FD+ R + DELSF+K D+IT+T+ DGGWWEGTL +GWFPSNYV + + E+ P+S + ++ + ++ +I + E++Y +L H+L TFL P L+ V + +L+ + + +++AL++ ++ VG ++ + +++ Y Y H + + TL+ + + E++ + + LS F RL +Y LLKE+ER++ED HPDR DI A+ + + +C +RK+K+ +L ++ I GW+GE + LG
Sbjct: 12 VRARFDFQRNNEDELSFSKGDVITVTRPEDGGWWEGTLGGRSGWFPSNYVRELKGNERPTSPKSKSSGKSVDSPISNKGYYNVVLQNIVETEREYWRELQHLLGTFLRPLHNSDKLSATDVSTLMGNLEDVCAFQQGLMQALEDCTKVPESQQTVGGCFMSLMNQMHGLYLAYCCNHPWAVRTLQEHSEVLGEFMESKGVSSPGLLMLTTSLSKPFMRLDKYPTLLKELERHMEDIHPDRNDIHGAMTAFKTLATQCREMRKRKELELQMMTEPIRGWEGEDMKALG 298
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003067.1 (pep scaffold:Pmarinus_7.0:GL477025:38822:89389:-1 gene:ENSPMAG00000002795.1 transcript:ENSPMAT00000003067.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 110.538 bits (275), Expect = 5.428e-26 Identity = 76/259 (29.34%), Postives = 122/259 (47.10%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-----------EKDG--PPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMK--STNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQL-----------LSLVFDRLSRYSLLLKEMERYLEDGHPDR 824
V A F + R + DELSF K D+IT+T+ GGWWEG + TGWFPSNYV + + K G PP+S + +V +I + E++Y +L +L+TFL P L + + +L+ I + ++ +L+E + VG ++ + S++ Y EY + H + + L+ +N+ ML ++ + K LS F RL +Y LLKE+ER++E P R
Sbjct: 171 VRAKFTFQRTNEDELSFEKGDVITVTRVEHGGWWEGAFNGHTGWFPSNYVRELKASDRPTSPKAVGSKGGAKPPESPPAAK------GYYDVVVKNIVETEQEYSKELHCLLATFLRPLQASDKLPPADMALLLGNLEVIASFQQSLVHSLEECAKLPEAQQHVGSCFMSLRSQMETLYLEYCANHPWAVKVLQ----------DNREMLGEFMESKGANSPGILMLTTSLSKPFMRLDKYPTLLKELERHIEVLSPKR 413
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ABI1 (abl interactor 1 [Source:HGNC Symbol;Acc:HGNC:11320]) HSP 1 Score: 59.3066 bits (142), Expect = 1.861e-9 Identity = 25/53 (47.17%), Postives = 38/53 (71.70%), Query Frame = 3
Query: 117 IKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
I+KV A++DY++ +DELSF++ II + ++ D GW+EG + TG FP NYV
Sbjct: 394 IEKVVAVYDYVQDKDDELSFHEGSIIYVVRKNDDGWYEGATNGHTGLFPGNYV 446
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ABI1 (abl interactor 1 [Source:HGNC Symbol;Acc:HGNC:11320]) HSP 1 Score: 58.5362 bits (140), Expect = 3.003e-9 Identity = 25/53 (47.17%), Postives = 37/53 (69.81%), Query Frame = 3
Query: 117 IKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
++KV A++DY + DELSF + II + ++ D GW+EGT++ TG FP NYV
Sbjct: 394 LEKVVAVYDYNKDKEDELSFQEGSIIYVIKKNDDGWYEGTMNGQTGLFPGNYV 446
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2 [Source:HGNC Symbol;Acc:HGNC:10830]) HSP 1 Score: 56.6102 bits (135), Expect = 1.039e-8 Identity = 24/47 (51.06%), Postives = 33/47 (70.21%), Query Frame = 3
Query: 135 LFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
L+D+ + EL F + DIITLT+QID W+EGT+ +G+FP NYV
Sbjct: 302 LYDFDPENEGELGFQEGDIITLTKQIDDNWYEGTVRGHSGFFPVNYV 348
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Yeast
Match: HSE1 (Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994]) HSP 1 Score: 60.4622 bits (145), Expect = 5.490e-10 Identity = 27/58 (46.55%), Postives = 36/58 (62.07%), Query Frame = 3
Query: 105 ANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVT 278
A T +++V AL+D DELSF K D+IT+ +Q+ WW+G L G FP NYVT
Sbjct: 215 AQTVVRRVRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVT 272
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO35631 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKW6]) HSP 1 Score: 110.153 bits (274), Expect = 9.765e-25 Identity = 81/292 (27.74%), Postives = 141/292 (48.29%), Query Frame = 3
Query: 291 EKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSV 1142
E G P + T L T + +V +I D E+ +VS+L +L +L P L+ ++ +C + + ++ + + LDE + R+G +L +A ++ E Y Y + H + L + + E++ + +L+L F L +Y LLKE+ER+LEDGH D D ++AI V+ +I CN +RKKK+ +L+IL I G E +++LGD IL + G D + ++ CLI+L+ + + + F+ K + N+SV
Sbjct: 335 ESKGAPAPGILT-----LTTSLSKVVQNILDTERAHVSELQALLQNYLKPLQYSNILSPRDLKVLCGNFEELVRFQQTLFGILDECAHLPLSSQRIGANFLQIAPQMKELYLTYCANHPRAVEVLTKYSDELSAFIESKG-----APAPGILTLTTSLSKPFCHLDKYPTLLKELERHLEDGHIDELDTKKAIPVFQNIKTSCNEMRKKKETELEILTGTIEGLDQEEINKLGDVILMAQFLIHG-----DEGEVRERYFLLFSSCLIILSVSAKLSGFCFERKYDISNISV 611 HSP 2 Score: 67.0106 bits (162), Expect = 2.286e-11 Identity = 28/63 (44.44%), Postives = 39/63 (61.90%), Query Frame = 3
Query: 117 IKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGP 305
++ V A F + DE+ F K DI+ +T+ +DGGWWEGTL+ GWFPSNYV + + P
Sbjct: 173 VRLVKATFPFEGTDEDEICFAKGDILEVTKVVDGGWWEGTLNGKNGWFPSNYVKEISASPEIP 235
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO45201 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTF1]) HSP 1 Score: 78.1814 bits (191), Expect = 3.176e-15 Identity = 73/291 (25.09%), Postives = 134/291 (46.05%), Query Frame = 3
Query: 132 ALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV------TDFEEEKDGPPQSDVKTSTDSHLLT---FQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDL-NECKVQRICDSLQAIIPLHKQIIEALDEMKSTNK---NRVGRLYLDMASKITESYYEYSSVHLFVIYTLEV--NKLAVQSHFENQRMLFDWSQVK--QLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDI--LCANILGWKGE 947
AL+D++ +EL+F D+IT+ + WW G + GWFP+ +V T +EE P + T+ LLT +A +VN I + EK YV LS ++ +L + K D+ +E ++ + +++ I H++++ L++ + + +GR++L+ + Y EY + H I L+ + FE R+L D + L ++ +Y L L E+ ++ H D + A+ ++ N ++K + I A I GW+GE
Sbjct: 10 ALWDHVTMDPEELTFRAGDVITVISMTNVDWWFGQVRDQVGWFPAPFVRVRVSQTLGDEENRLIPPFRSRRGTNEGLLTKDDVRARVVNEILNTEKDYVKNLSDVVEGYLCQAQKRVDMFSEDQIYLLFSNIEQIYEFHQKLLLQLEDCYLKDNPCDSMIGRVFLENKEGF-QIYSEYCNNHPHAIAELKTLCESNNYKHFFEACRLLQDMINISLDGFLLTPVQKICKYPLQLAELLKHTYPTHKDYDAVHDALRTMKEVASLINERKRKVENIYKIAKWQATIEGWEGE 299
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO38999 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBA8]) HSP 1 Score: 62.7734 bits (151), Expect = 5.150e-10 Identity = 42/112 (37.50%), Postives = 55/112 (49.11%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQ----IDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFL-IPSL 446
V AL+DY ++ELSFN+ D I +T+Q +D G+WEG +D G FPS V + E PP + S S Q N W G YV L+ ST + PSL
Sbjct: 654 VRALYDYEAMSDEELSFNEGDTIYVTKQDDHGVDDGFWEGYIDGHKGVFPSLVVEEIEGSASPPPVTTPVVSPPSTGQEAQPPATNAGWQGRGDYVD-LADSYSTIVKAPSL 764
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO38147 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDP5]) HSP 1 Score: 56.225 bits (134), Expect = 6.713e-10 Identity = 27/54 (50.00%), Postives = 38/54 (70.37%), Query Frame = 3
Query: 117 IKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEG-TLDQITGWFPSNYV 275
++KV AL+DY +DEL+F +N II + ++ D GW+EG T D +TG FP NYV
Sbjct: 44 LEKVIALYDYNATRDDELTFAENTIIYVIKKNDDGWYEGVTTDGLTGLFPGNYV 97
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO47147 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMS4]) HSP 1 Score: 54.6842 bits (130), Expect = 8.360e-10 Identity = 25/48 (52.08%), Postives = 31/48 (64.58%), Query Frame = 3
Query: 132 ALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
AL+ Y + +D LSFNKNDII + +Q D WW G L+ GWFP YV
Sbjct: 12 ALYPYRGKKDDMLSFNKNDIIAIKEQQD-TWWSGELNGKKGWFPKTYV 58
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef7a (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:101166510]) HSP 1 Score: 187.578 bits (475), Expect = 1.449e-49 Identity = 165/602 (27.41%), Postives = 278/602 (46.18%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHL------LTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDW-SQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRS-ELTG---EYLHLIC----DSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIE-----HASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAK 1862
V A F++ + + DEL+FNK DII +T+Q +GGWWEGTL TGWFPSNYV + + +K P+S S T+ ++ +I + E Y + +L+ +L P L+ V I +++ I + ++++L+E + RVG +L++ ++ Y Y S H + L + A+ E + + + LS F RL +Y LLKE+ER++E+ H DR DIQ+ +V + +++ +C +RK+K+ +L IL +I W+G+ + LG I +V P S++ L ++ P L++L+ + + + F+ KL L + V ++C + EL G + L +IC D + L IK A+ T K L V + + PV SR EG+ + H SS S + P E KP + L LRP PP + C ++ SPK+ ++ R EE +L++S +++DA +L+VIE+YC S+K +L+ R + +I + VF E+ ++
Sbjct: 99 VKARFNFQQTNEDELTFNKGDIINVTRQEEGGWWEGTLSGRTGWFPSNYVREVKGSDKQVSPKSGTLKSPPKGFEPPAISKTYYNLVLQNILETETAYSKDIQSLLTNYLRPLQNSDKLSSSDVALILGNMEEISTFQQMLVQSLEECTKLPESHQRVGSFFLNLMPQMKALYIGYCSNHPSAVNVLTQHSEALGEFMEGRGAVSPGILTLTTGLSKPFMRLDKYPTLLKELERHMEEIHLDRPDIQKCMVSFKNLSAQCQEVRKRKELELQILTESIRLWEGDDIKTLGSVIYMSQVLVQSPMTEEKSERYL----LLFPHVLLMLSASPRMSGFIFQGKLPLTGMMV-TKLEDCEAHKNTFELNGTLFDRLQVICTNQQDLQDWVEHLTRQIKHATATAP-----SHKPL-------TVPCHTLPSHPV-TPSRHAEGRAMTVAPTYHTLPHPSSHGTSHSTMMWGPLEPPNTPKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKSVKKLLPKRKPERKQSEEEF----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN--SRRETGLHVIIPGEDKVFVEDPSR 664
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef7a (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:101166510]) HSP 1 Score: 186.037 bits (471), Expect = 3.300e-49 Identity = 160/579 (27.63%), Postives = 269/579 (46.46%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHL------LTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDW-SQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRS-ELTG---EYLHLIC----DSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIE-----HASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLAR 1793
V A F++ + + DEL+FNK DII +T+Q +GGWWEGTL TGWFPSNYV + + +K P+S S T+ ++ +I + E Y + +L+ +L P L+ V I +++ I + ++++L+E + RVG +L++ ++ Y Y S H + L + A+ E + + + LS F RL +Y LLKE+ER++E+ H DR DIQ+ +V + +++ +C +RK+K+ +L IL +I W+G+ + LG I +V P S++ L ++ P L++L+ + + + F+ KL L + V ++C + EL G + L +IC D + L IK A+ T K L V + + PV SR EG+ + H SS S + P E KP + L LRP PP + C ++ SPK+ ++ R EE +L++S +++DA +L+VIE+YC S+K +L+ ++
Sbjct: 87 VKARFNFQQTNEDELTFNKGDIINVTRQEEGGWWEGTLSGRTGWFPSNYVREVKGSDKQVSPKSGTLKSPPKGFEPPAISKTYYNLVLQNILETETAYSKDIQSLLTNYLRPLQNSDKLSSSDVALILGNMEEISTFQQMLVQSLEECTKLPESHQRVGSFFLNLMPQMKALYIGYCSNHPSAVNVLTQHSEALGEFMEGRGAVSPGILTLTTGLSKPFMRLDKYPTLLKELERHMEEIHLDRPDIQKCMVSFKNLSAQCQEVRKRKELELQILTESIRLWEGDDIKTLGSVIYMSQVLVQSPMTEEKSERYL----LLFPHVLLMLSASPRMSGFIFQGKLPLTGMMV-TKLEDCEAHKNTFELNGTLFDRLQVICTNQQDLQDWVEHLTRQIKHATATAP-----SHKPL-------TVPCHTLPSHPV-TPSRHAEGRAMTVAPTYHTLPHPSSHGTSHSTMMWGPLEPPNTPKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKSVKKLLPKRKPERKQSEEEF----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSK 631
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef7a (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:101166510]) HSP 1 Score: 186.037 bits (471), Expect = 6.019e-49 Identity = 160/576 (27.78%), Postives = 267/576 (46.35%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFE-EEKDGPPQSDVKTSTDSHL------LTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDW-SQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRS-ELTG---EYLHLIC----DSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIE-----HASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLD 1784
V A F++ + + DEL+FNK DII +T+Q +GGWWEGTL TGWFPSNYV + + +K P+S S T+ ++ +I + E Y + +L+ +L P L+ V I +++ I + ++++L+E + RVG +L++ ++ Y Y S H + L + A+ E + + + LS F RL +Y LLKE+ER++E+ H DR DIQ+ +V + +++ +C +RK+K+ +L IL +I W+G+ + LG I +V P S++ L ++ P L++L+ + + + F+ KL L + V ++C + EL G + L +IC D + L IK A+ T K L V + + PV SR EG+ + H SS S + P E KP + L LRP PP + C ++ SPK+ ++ R EE +L++S +++DA +L+VIE+YC S+K +L+
Sbjct: 168 VKARFNFQQTNEDELTFNKGDIINVTRQEEGGWWEGTLSGRTGWFPSNYVREVKGSDKQVSPKSGTLKSPPKGFEPPAISKTYYNLVLQNILETETAYSKDIQSLLTNYLRPLQNSDKLSSSDVALILGNMEEISTFQQMLVQSLEECTKLPESHQRVGSFFLNLMPQMKALYIGYCSNHPSAVNVLTQHSEALGEFMEGRGAVSPGILTLTTGLSKPFMRLDKYPTLLKELERHMEEIHLDRPDIQKCMVSFKNLSAQCQEVRKRKELELQILTESIRLWEGDDIKTLGSVIYMSQVLVQSPMTEEKSERYL----LLFPHVLLMLSASPRMSGFIFQGKLPLTGMMV-TKLEDCEAHKNTFELNGTLFDRLQVICTNQQDLQDWVEHLTRQIKHATATAP-----SHKPL-------TVPCHTLPSHPV-TPSRHAEGRAMTVAPTYHTLPHPSSHGTSHSTMMWGPLEPPNTPKPWS--LSCLRPAPPLRPSAALCYKE----------DLSKSPKSVKKLLPKRKPERKQSEEEF----ALRKSTAALEEDAQILKVIEAYCTSAKTRQTLN 709
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef7b (rho guanine nucleotide exchange factor 7 [Source:NCBI gene;Acc:101156802]) HSP 1 Score: 177.948 bits (450), Expect = 4.303e-46 Identity = 147/584 (25.17%), Postives = 265/584 (45.38%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDF---EEEKDGPPQSDVKTST---DSHLL--TFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKS--TNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLV------FDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTG---EYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEII 1820
V A F + + + DELSF+K DII + +Q +GGWWEG+L+ TGWFPSNYV + ++ D P +K+ D+ ++ T+ ++ +I + E +Y +L +L ++L L+ + I +L+ I + ++++LD+ N+ R+G +L + ++ Y Y S H + L + + E++ + +L+L F RL RY LLKE+ER++ED HPDR D+ + + + +C +RK+KD +L IL I W+GE + LG + +V+ + Q+ +V+ P L++L+ + + + ++ ++ L + + D N E++G E + + C+S + + + + + T + +L S T S + G H SS S S P E KP + L LRP PP + C ++ SPK ++ R EE + V ++S +++DA +L+VIE+YC S+K +L+ +R D +++
Sbjct: 168 VKARFPFQQTNEDELSFSKGDIIVVRRQEEGGWWEGSLNGKTGWFPSNYVRELKGSDKTADKPKSGTLKSPPKGFDTSIISKTYYNVVLQNILEAETEYSRELQSLLGSYLRSLQPTDRLSSGDISHIQANLEEISTFQQMLVQSLDDQTKLPENQQRIGGFFLSLMPQMKTIYVSYCSNHPSAVGVLTRHSEELGGFMESK-----GASSPGILALTTSLSKPFTRLDRYPALLKELERHMEDQHPDRADLHAVMAAFKHLAAECQEVRKRKDLELQILTEPIRNWEGEDIKSLGAVLHMSQVTVHSQ----NCQEVNERYLVLFPHTLLVLSASLRMSGFIYQGRMPLSGMLISRIEDGENWRNAFEISGGQCERMQVACNSQRDLQDWLDLLTKHTHTPAH------------THRPPCHTLPSHTVTSSRHSEARAGSSAYHTLPHLSSCETSHSAPSWGPLEPPSTPKPWS--LSCLRPAPPLRPSAALCFKE----------DMSKSPKNMKKLLPKRKPERKPSEEDVTV----RKSTAALEEDAQILKVIEAYCTSAKTRQTLN-SRCSRKDVQML 713
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:NCBI gene;Acc:101166805]) HSP 1 Score: 177.178 bits (448), Expect = 4.884e-46 Identity = 153/569 (26.89%), Postives = 260/569 (45.69%), Query Frame = 3
Query: 126 VTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEE-EKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKST--NKNRVGRLYLDMASKITESYYEYSSVHLFVIYTL-----EVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPI---DSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIR 1799
V A F++ + + DELSFNK ++I +T+Q +GGWWEG+L+ TGWFPSNYV + + EK P+ T ++ + DI+ H E+++V +L +L+ +L P L +C +L+ I+ + + ALD+ + RV YL++ +I Y Y S H + L E++K + +L + LS F RL +Y LL+E+ER++E+ HPD DI +A + + +C +RK+K+ ++ IL + GW+G+ + LG +VSY+ V + S++ +++ P L++L+ + + + F+ KL+L +V + +E ++ + E + + C S + E L Q G + I S +V S +P P S+ GS S P E KP + L LRP PP + ++ R S SP+ ++ G K P + M ++S +++DA +L+VIE+YC SL A +R
Sbjct: 164 VKARFNFKQNNEDELSFNKGEVILVTRQEEGGWWEGSLNGKTGWFPSNYVREVKPCEKPLSPKGT--PLTKNYYMVVVQDILEH----EREFVKELQTVLTCYLRPLQACDKLPSADSATLCGNLEEILTFQQDLCSALDDCTKVPEGQQRVAACYLNLMPQIKNLYLTYCSSHPSAVCILTDHSEELDKFMESQGASSPGIL----NLTTSLSKPFMRLDKYPTLLQELERHVEEAHPDYTDILKATAAFRSLVAQCQDLRKRKNLEIQILSEPVRGWEGDSMRSLG------QVSYMS-QVHMRNGGSEEKEERYLMLFPNLLVMLSASPRMSGFIFQGKLSLAGTTVTRHVEEEAFDITGGMM-ERITVFCSSAQDLQEW--------LEHLQPFTKGGSPGSTITKSVDVKPPSMVGAPTP-------------VSHPGSF-----SAASRGPLEPPKTSKPWS--LSCLRPAPPLKPSAALGYKE----RMSYIMKDSKSPRPMKKFLPGNRKKERKPSDDEFQM---RKSMAALEEDAQILRVIEAYCTGV----SLQTATVR 675
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000018733.1 (SMESG000018733.1) HSP 1 Score: 1322.76 bits (3422), Expect = 0.000e+0 Identity = 680/681 (99.85%), Postives = 680/681 (99.85%), Query Frame = 3
Query: 102 MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAKQQQPRNLVAXXXXXXXXXXXXNTTASGDXXXXXXXXXXXXXXXRRLEMNSAIMTPCQLNIRGHERGGCTCVAQTVTSKPIGCAPMISGRNKKKS 2144
MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAKQQQPRNLVAESVRGRESSGSSNTTASGDNNNINSNNNANNPANRRLEMNSAIMTPCQLNIRGHERGGC CVAQTVTSKPIGCAPMISGRNKKKS
Sbjct: 1 MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAKQQQPRNLVAESVRGRESSGSSNTTASGDNNNINSNNNANNPANRRLEMNSAIMTPCQLNIRGHERGGCACVAQTVTSKPIGCAPMISGRNKKKS 681
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000018733.1 (SMESG000018733.1) HSP 1 Score: 1271.91 bits (3290), Expect = 0.000e+0 Identity = 660/681 (96.92%), Postives = 661/681 (97.06%), Query Frame = 3
Query: 102 MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKEGRLKSAINPEEVLRVMDSLKESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAKQQQPRNLVAXXXXXXXXXXXXNTTASGDXXXXXXXXXXXXXXXRRLEMNSAIMTPCQLNIRGHERGGCTCVAQTVTSKPIGCAPMISGRNKKKS 2144
MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKE +ESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAKQQQPRNLVAESVRGRESSGSSNTTASGDNNNINSNNNANNPANRRLEMNSAIMTPCQLNIRGHERGGC CVAQTVTSKPIGCAPMISGRNKKKS
Sbjct: 1 MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDFEEEKDGPPQSDVKTSTDSHLLTFQADIVNHIWDGEKKYVSKLSHMLSTFLIPSLKIPDLNECKVQRICDSLQAIIPLHKQIIEALDEMKSTNKNRVGRLYLDMASKITESYYEYSSVHLFVIYTLEVNKLAVQSHFENQRMLFDWSQVKQLLSLVFDRLSRYSLLLKEMERYLEDGHPDRGDIQRAIVVYTDINEKCNTIRKKKDRDLDILCANILGWKGERLSQLGDPILTIKVSYIGPSVPIDSQKALNHVVVVMPICLILLACTEQADIYTFKSKLALENLSVYINSDECNIEMRSELTGEYLHLICDSPETRNELVLSIKQASLTQSQGINGGSKSLNMIESSSNVASLSSDTSPVPNVSRSTEGKIIEHASNDGSSINLSDQNVSLRPKEFNIVYKPTNEHLRILRPDPPAAANLISCSQQIPVTRSSSGAGGQFSPKAARRKKE-------------------EESCPKMKDDALVLQVIESYCVSSKGSNSLDLARIRLSDAEIIRSSNNWVFNENAAKQQQPRNLVAESVRGRESSGSSNTTASGDNNNINSNNNANNPANRRLEMNSAIMTPCQLNIRGHERGGCACVAQTVTSKPIGCAPMISGRNKKKS 662
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000055438.1 (SMESG000055438.1) HSP 1 Score: 56.9954 bits (136), Expect = 4.072e-8 Identity = 24/60 (40.00%), Postives = 38/60 (63.33%), Query Frame = 3
Query: 105 ANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYVTDF 284
N I KV L++Y + +DELSF + ++I + ++ + GWWEG ++ TG FP NYV +
Sbjct: 446 PNQYICKVITLYEYQQNKDDELSFQEGELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQNM 505
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000043383.1 (SMESG000043383.1) HSP 1 Score: 54.299 bits (129), Expect = 2.016e-7 Identity = 22/54 (40.74%), Postives = 32/54 (59.26%), Query Frame = 3
Query: 114 KIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
++ AL+D+ EL FN+ D+I L QQ+D W+EG + G+FP NYV
Sbjct: 301 RVPTCRALYDFKAESEAELQFNEGDVIKLLQQVDDSWFEGEHNNRKGFFPINYV 354
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000022674.1 (SMESG000022674.1) HSP 1 Score: 53.5286 bits (127), Expect = 3.306e-7 Identity = 26/69 (37.68%), Postives = 40/69 (57.97%), Query Frame = 3
Query: 75 LKINFNK*KMANTKIKKVTA--LFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITGWFPSNYV 275
K N ++ AN +K+ A LFD+ + EL F + +I+ L QQ+D W+EG ++ G+FP NYV
Sbjct: 286 FKSNTSQYPTANGSLKEPCARGLFDFEAENETELCFKEGEIVKLIQQVDENWFEGEVNGRQGYFPVNYV 354 The following BLAST results are available for this feature:
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004175 ID=SMED30004175|Name=Rho guanine nucleotide exchange factor|organism=Schmidtea mediterranea sexual|type=transcript|length=2391bpback to top protein sequence of SMED30004175-orf-1 >SMED30004175-orf-1 ID=SMED30004175-orf-1|Name=SMED30004175-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=682bp MANTKIKKVTALFDYIRRHNDELSFNKNDIITLTQQIDGGWWEGTLDQITback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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