Cellular communication network factor 4

Overview
NameCellular communication network factor 4
Smed IDSMED30004083
Length (bp)1235
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cellular communication network factor 4 (SMED30004083) t-SNE clustered cells

Violin plots show distribution of expression levels for Cellular communication network factor 4 (SMED30004083) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cellular communication network factor 4 (SMED30004083) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cellular communication network factor 4 (SMED30004083) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004083

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30004083SMESG000036248.1 SmedASXL_008876SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30004083SMESG000036248.1 dd_Smed_v4_18465_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30004083SMESG000036248.1 dd_Smed_v4_18465_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30004083SMESG000036248.1 dd_Smed_v4_18465_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
non-ciliated neuronSMED30004083SMESG000036248.1 dd_Smed_v4_18465_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30004083SMESG000036248.1 dd_Smed_v4_18465_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30004083SMESG000036248.1 dd_Smed_v6_18465_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30004083SMESG000036248.1 dd_Smed_v4_18465_0_1dd_Smed_v4PMID:30962434
Cote et al., 2019		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Human
Match: CCN2 (cellular communication network factor 2 [Source:HGNC Symbol;Acc:HGNC:2500])

HSP 1 Score: 131.724 bits (330), Expect = 3.493e-34
Identity = 98/306 (32.03%), Postives = 131/306 (42.81%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   CIF G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       +    +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T  P  S  I+  L            C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   51 LDGCGCCRVCAKQLGELCTERDPCDPHKGLFCHFGSPANRKI---------GVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANC---LVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRT--PKISKPIKFELSG----------CTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCAC 325
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Human
Match: CCN3 (cellular communication network factor 3 [Source:HGNC Symbol;Acc:HGNC:7885])

HSP 1 Score: 125.176 bits (313), Expect = 8.175e-32
Identity = 93/308 (30.19%), Postives = 135/308 (43.83%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQ--IDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGAC--FHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D C CC  C R  GE C  +  CD +  L+C    D S+  GIC  +E              C+F+G++Y+S  +F  SC+ +C C DG + C   CQ ++   P P    P   E+      +CC +W C  D    L    +   R         ++S+  C   ++  T W+ CSK CGMG STR +  N  C  + Q R CM R C  + E  P + K ++C  T +   +  +Q               C S   ++PRFCG C    CC P ++KT + EF+CS      +    I  C C
Sbjct:   58 LDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEG-----------DNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQ-LDVLLPEPNCPAPRKVEV----PGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNC---IEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQ-PTDKKGKKCLRTKKSLKAIHLQFK------------NCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTC 333
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Human
Match: CCN4 (cellular communication network factor 4 [Source:HGNC Symbol;Acc:HGNC:12769])

HSP 1 Score: 122.094 bits (305), Expect = 1.740e-30
Identity = 86/315 (27.30%), Postives = 129/315 (40.95%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN---GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXK------LQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D C CC+ C + +G+ C    +CD  R L+C           G+C  +  +            C+ +G+ Y +   F  +C++ C C DG V C  LC  +     PP   CPH   +  S    CC +W C++D             R RK         + +   +      +   +PWS CS  CG+G+STR S  N  C    + R C  R C   +  + K  K              K   V   E + NF+   C+S R ++P++CG C    CC P  SKT  + F+C D +   +   WI  C C+
Sbjct:   71 DGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVG-----------CVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVR----PPRLWCPHPRRV--SIPGHCCEQWVCEDDAK-----------RPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGK--------------KCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCN 343
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Human
Match: CCN1 (cellular communication network factor 1 [Source:HGNC Symbol;Acc:HGNC:2654])

HSP 1 Score: 113.235 bits (282), Expect = 2.940e-27
Identity = 99/339 (29.20%), Postives = 143/339 (42.18%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSN--NGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYL--------GVLSDQL------VTFLRKRKIYXXXXXXXXXXXXX----------KLQAD------TPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKV-EAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D CGCC+ C + + E C     CDHT+ L C    SS    GIC+           ++  + C +N  +YQ+   F  +C+H+C C DG V C  LC    Q    P   CP+   L+  +  QCC EW C  D +        G+L  +L      V   R  ++      +S K               LQ        T WS+CSK CG GISTR + +N  C  V + R C  R C   V  ++ K  K  +   +  P                 F+   CLS +K+RP++CG+C    CC P  ++T ++ F C D     +    I+ C C+
Sbjct:   48 DGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICR----------AQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLC---PQELSLPNLGCPN-PRLVKVT-GQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPV---------------RFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCN 356
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Human
Match: CCN6 (cellular communication network factor 6 [Source:HGNC Symbol;Acc:HGNC:12771])

HSP 1 Score: 92.4337 bits (228), Expect = 4.221e-20
Identity = 93/310 (30.00%), Postives = 131/310 (42.26%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQ--IDESS-NNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSK 1157
            D CGCC+ C +  GE C+  +LCD  + L+C   +D      G+C Y   L+    E N  ++   NG V+Q +  FS      C C  G + C  L   I + A    S    GA+    SD   C         L  L  QL T  +    Y N+     K C   L   T W+ CS+ CGMGIS R +  N  C    +KR C  + C + +    K  K + C PT + + +            E F    C S + ++P FCG C    CC P  SK   I+F+C ++ +      WI  C C +
Sbjct:   70 DGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAY---LVAVGCEFN--QVHYHNGQVFQPNPLFS------CLCVSGAIGCTPL--FIPKLAGSHCS----GAKGGKKSDQSNCS--------LEPLLQQLSTSYKTMPAYRNLPLIWKKKC---LVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKA------------EKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQR 339
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Zebrafish
Match: ccn2a (cellular communication network factor 2a [Source:ZFIN;Acc:ZDB-GENE-030131-102])

HSP 1 Score: 140.969 bits (354), Expect = 6.370e-38
Identity = 96/306 (31.37%), Postives = 138/306 (45.10%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   ++CD  + L+C     SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  ++   P P    P   ++      +CC EW C +          +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C + +E   K  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   47 LDTCGCCRVCAKQLGELCTERDVCDPHKGLYCDYGSPSNRRI---------GVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDIRLPSPDCPMPRRVKV----PGKCCEEWVCDSPRQNTFVGSALAAYREEETYGPDPSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEE--KIRKGKKCIRTPRVSKPMKFEIS------------GCTTTKSYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCAC 321
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Zebrafish
Match: ccn2a (cellular communication network factor 2a [Source:ZFIN;Acc:ZDB-GENE-030131-102])

HSP 1 Score: 140.969 bits (354), Expect = 6.370e-38
Identity = 96/306 (31.37%), Postives = 138/306 (45.10%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   ++CD  + L+C     SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  ++   P P    P   ++      +CC EW C +          +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C + +E   K  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   47 LDTCGCCRVCAKQLGELCTERDVCDPHKGLYCDYGSPSNRRI---------GVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDIRLPSPDCPMPRRVKV----PGKCCEEWVCDSPRQNTFVGSALAAYREEETYGPDPSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEE--KIRKGKKCIRTPRVSKPMKFEIS------------GCTTTKSYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCAC 321
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Zebrafish
Match: ccn1 (cellular communication network factor 1 [Source:ZFIN;Acc:ZDB-GENE-040426-3])

HSP 1 Score: 123.25 bits (308), Expect = 3.713e-31
Identity = 108/381 (28.35%), Postives = 164/381 (43.04%), Query Frame = 3 
Query:  114 VIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCP-----QFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDES--SNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLG------------------------VLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSK 1157
            VIF+ HF        +++SS    +C   CS C  +   CP     Q D CGCC  C R + E C     CDH++ L C    S  +  GIC+           ++  + C ++  +YQ+   F  +C+H+C C DG V C  LC   E S P      P   ++      +CC EW C ++  G                           ++L++ +   K+ +     S+++    +Q  T WS+CS+ CG GISTR + NN  C  + + R C  R C        K  K ++C  T +     K            FS   C S +K+RPRFCG+C    CC P +++T R++F C D     +    I+ C C+K
Sbjct:    8 VIFIAHF--------NMVSS----SCPAVCS-CAPDAPQCPPGVGLQRDACGCCLVCARQLNEDCSRSEPCDHSKGLECNYGASHGATRGICR----------AKSEGRPCEYSSRIYQNGESFQPNCKHQCTCMDGAVGCVPLCPQ-ELSLPALGCANPRLVKV----PGRCCEEWVCDDEQQGGKLIESANKMPGNKEVGGDSEKELTNKNELISVIMNTKLKSLPAFRSHQMEKCIVQT-TGWSQCSRSCGTGISTRITNNNAECKLMKESRICEVRPCSQSPHTSLK--KGKKCNRTKKSVTPVK------------FSYAGCSSLKKYRPRFCGSCVDGRCCSPQNTRTIRVKFRCQDGETFNKNVMMIESCKCTK 345
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Zebrafish
Match: ccn4b (cellular communication network factor 4b [Source:ZFIN;Acc:ZDB-GENE-080220-16])

HSP 1 Score: 122.479 bits (306), Expect = 6.185e-31
Identity = 98/347 (28.24%), Postives = 146/347 (42.07%), Query Frame = 3 
Query:  150 VSQDLISSQKNINCNKTCSQCYKELIYCPQ-----FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESS---NNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSD--QLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            ++ +L    +N  C   C +C K  + CP       D C CC++C +  GE C+  ++CD+ + L+C           G+C Y+               C +NG++Y++   F  +C++RC C +G + C  LC     S PP +         IP    QCC +W C+       ++       +    I++N            +   TPWS CSK CG GIS R S  N  CV   + R C  R C   +            T   RP    K   +      +NF+   C+SK+ + P++CG C    CC P  SKT  +EFEC D       Y WI  C C+
Sbjct:   28 MTTELDPYNRNRYCKWPC-KCPKSALVCPHGVSLLTDGCDCCKACAKQAGETCNERDICDYHKGLYCDYSADKPRYEKGVCAYVMGTG-----------CEYNGVIYRNGQSFQPNCKYRCLCVNGAIGCVPLCT---DSLPPRVWCQSPKRVKIPG---QCCEKWICEESRKPRKTNPRHAPAEVSANDIWHNNC----------IAQTTPWSPCSKTCGRGISLRISNENAGCVMEKESRLCNLRPCEVDI------------TKHFRPG--KKCLNIYREPEFQNFTISGCVSKKPYWPKYCGVCTDERCCIPYKSKTIEVEFECPDGALLTWKYMWINACFCN 332
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Zebrafish
Match: ccn2b (cellular communication network factor 2b [Source:ZFIN;Acc:ZDB-GENE-070705-82])

HSP 1 Score: 121.324 bits (303), Expect = 1.333e-30
Identity = 105/368 (28.53%), Postives = 156/368 (42.39%), Query Frame = 3 
Query:   93 FKNVCFYVIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQ-----FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQ--IDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAEL-IPSSDNQCCREWSC-----KNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            F   C  +  L H  I  D SQ                 C  E   CP       D C CC+ C R  GE C  +  CDH + L+C   +   +  GIC   E            + C   G++Y+S   F  SC+H+C C +G + C   C  I +   P    CP+   + IP    +CC EW C     ++ +   ++ + + +   R+I  +     +   N  +Q  T WS+CS  CGMG+S+R + +N  C    Q R CM R C   +E   K  K  +C  T  P + S ++  L            C S R ++P+FCG C    CC P S+ T  +EF C +  +  +   +IK C+C
Sbjct:    6 FTRACIALSLLIHTAICQDCSQPC--------------DCPDESPLCPVGTSLVLDGCSCCKVCARQAGEPCSFLEPCDHHKGLYCDYSVLSDTETGICMAQEG-----------QTCDLGGVIYRSGETFQPSCKHQCVCMNGEIGCVPTCATIIRLPSPD---CPYPRRVQIP---GKCCEEWVCDQIPQEDTFQSAVAGRSIAY---REISAHGLQPESARDNCIVQT-TEWSECSATCGMGVSSRVTNDNEQCQLERQTRMCMIRPCHADLEKDIKRGK--KCVRT--PKSQSGMRFELSG----------CQSIRLYKPKFCGVCTDDRCCTPQSTITAEVEFRCPEGDSFRKKMMFIKTCSC 324
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Xenopus
Match: ccn2 (cellular communication network factor 2 [Source:NCBI gene;Acc:548598])

HSP 1 Score: 131.724 bits (330), Expect = 1.949e-34
Identity = 98/307 (31.92%), Postives = 134/307 (43.65%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN--GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            D CGCC+ C + +GE C   ++CD  + LFC      N   G+C   E              C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       L    +   R  + Y    +     C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + +   K +I              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   36 DGCGCCKVCAKQLGELCTERDVCDPHKGLFCDFGSRVNRKIGVCTAREG-----------APCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLC-SMDIRLPSPECPFPRRVKL----PGKCCEEWVCDQPQERTLVGPALPAFRMEETYGPDPSLIRANC---LVQTTEWSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKISKPVKFEIS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKKNMMFIKTCAC 309
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Xenopus
Match: ccn2 (cellular communication network factor 2 [Source:NCBI gene;Acc:548598])

HSP 1 Score: 131.724 bits (330), Expect = 2.513e-34
Identity = 98/307 (31.92%), Postives = 134/307 (43.65%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN--GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            D CGCC+ C + +GE C   ++CD  + LFC      N   G+C   E              C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       L    +   R  + Y    +     C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + +   K +I              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   46 DGCGCCKVCAKQLGELCTERDVCDPHKGLFCDFGSRVNRKIGVCTAREG-----------APCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLC-SMDIRLPSPECPFPRRVKL----PGKCCEEWVCDQPQERTLVGPALPAFRMEETYGPDPSLIRANC---LVQTTEWSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKISKPVKFEIS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKKNMMFIKTCAC 319
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Xenopus
Match: ccn2 (cellular communication network factor 2 [Source:NCBI gene;Acc:548598])

HSP 1 Score: 131.339 bits (329), Expect = 4.539e-34
Identity = 98/307 (31.92%), Postives = 134/307 (43.65%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN--GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            D CGCC+ C + +GE C   ++CD  + LFC      N   G+C   E              C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       L    +   R  + Y    +     C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + +   K +I              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   59 DGCGCCKVCAKQLGELCTERDVCDPHKGLFCDFGSRVNRKIGVCTAREG-----------APCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLC-SMDIRLPSPECPFPRRVKL----PGKCCEEWVCDQPQERTLVGPALPAFRMEETYGPDPSLIRANC---LVQTTEWSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKISKPVKFEIS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKKNMMFIKTCAC 332
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Xenopus
Match: CCN4 (cellular communication network factor 4 [Source:NCBI gene;Acc:100492186])

HSP 1 Score: 115.931 bits (289), Expect = 1.766e-28
Identity = 92/315 (29.21%), Postives = 133/315 (42.22%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN---GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXK------LQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D C CC++C +  GE C   + CD  + L+C     S     G+C  M  +            C+ NG+ Y +   F  +C++ C C +G V C  LC     ++ PP+  C +   +      +CC +W C +            F R RK       +      ++      +   T WS CSK CG+GISTR S  N  C    ++R C  R C         ++ I Q   T +     K   V      +NF+   CLSKR +RP++CG C    CC P  SKT ++EFEC D         WI  C C+
Sbjct:   63 DGCDCCKTCAKQRGENCTEADTCDTHKGLYCDYSGDSPRYEVGVCGQMTGVG-----------CVLNGIRYVNGQSFQPNCKYNCTCVNGDVGCVPLC----TNSRPPLVWCQNPKRV--KMTGKCCEQWICDD------------FKRVRKTSPRHIASPAYGGESESWHNNCIVQTTSWSPCSKTCGLGISTRISNENDKCRLRKERRLCDMRPC---------DVDITQHIRTGK-----KCLSVYREAEPKNFTISGCLSKRPYRPKYCGVCTDDRCCIPYKSKTIQVEFECPDGSGFTWNVMWINACFCN 334
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Xenopus
Match: CCN6 (cellular communication network factor 6 [Source:NCBI gene;Acc:100488354])

HSP 1 Score: 111.309 bits (277), Expect = 4.352e-27
Identity = 99/319 (31.03%), Postives = 133/319 (41.69%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN---GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRC-------QCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCC--REWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGAC--FHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSK 1157
            D CGCC+ C + +GE C+  ++CDH R L+C           GICKYM  L  G         C  NG++Y++   F  S  + C        CT  LV  QD  Q +     P IS            DN  C   + S K DY      +++  + KRK                L   T WS CSK CGMGIS R S  N  C    ++R C+ R C   + +  K  K + C PT +P    K+ +          SE  C S R ++P +CG C    CC P  SK   + F C ++ +      WI  C C K
Sbjct:   39 DGCGCCKICAKQLGESCNEADVCDHHRGLYCDYSADRPKYEVGICKYM--LAVG---------CELNGVLYKNGQTFQPSPHYLCLCISDTIGCTPTLVGKQDQNQCVTSPGQPKIS------------DNANCALEKDSYKPDYKFTPVYKVLPLVWKRKC---------------LVHATQWSPCSKTCGMGISIRVSNENNKCERRQERRLCILRPCNATLLSTIKVPKGKTCQPTFQPPQPVKMVL----------SE--CSSVRTYKPTYCGVCKDRRCCIPNKSKMITVRFNCPNEGSFSWKMMWITSCVCQK 307
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Mouse
Match: Ccn2 (cellular communication network factor 2 [Source:MGI Symbol;Acc:MGI:95537])

HSP 1 Score: 130.954 bits (328), Expect = 3.684e-34
Identity = 95/306 (31.05%), Postives = 130/306 (42.48%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C            +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + A   K ++              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   50 LDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKI---------GVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANC---LVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKIAKPVKFELS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCAC 324
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Mouse
Match: Ccn3 (cellular communication network factor 3 [Source:MGI Symbol;Acc:MGI:109185])

HSP 1 Score: 123.25 bits (308), Expect = 2.904e-31
Identity = 87/290 (30.00%), Postives = 131/290 (45.17%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN--GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGAC--FHCCEPVSSKTKRIEFEC 1097
             D C CC  C R  GE C  +  CD +  L+C      NN  GIC   E              C+F+G++Y++  +F  +C++ C C DG + C   CQ ++   P P    P    +      +CC +W+C +D  G         L   +    +    +    N ++  T WS CSK CGMG+STR +  N  C  V Q R C+ R C  + E +  + K ++C  T +   +  +Q        EN     C S   ++PRFCG C    CC P ++KT ++EF+C
Sbjct:   52 LDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNQTGICMVPEG-----------DNCVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPRCQ-LDVLLPGPDCPAPRKVAV----PGECCEKWTCGSDEQGTQGTLGGLALPAYRPEATVGVEVSDSSINCIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEV-TDKKGKKCLRTKKSLKAIHLQF-------EN-----CTSLYTYKPRFCGVCSDGRCCTPHNTKTIQVEFQC 312
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Mouse
Match: Ccn4 (cellular communication network factor 4 [Source:MGI Symbol;Acc:MGI:1197008])

HSP 1 Score: 114.39 bits (285), Expect = 7.144e-28
Identity = 86/309 (27.83%), Postives = 126/309 (40.78%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN---GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D C CC+ C + +G+ C    +CD  R L+C           G+C  +  +            C+ +G+ Y +   F  +CR+ C C DG V C  LC     S  PP   C     +      QCC +W C +D       +    L  R    +            +   +PWS CS  CG+GISTR S  N  C    + R C  R C   ++     L I+        A    + +  P E   NF+   C+S R +RP++CG C    CC P  SKT  ++F+C +     +   WI  C C+
Sbjct:   71 DGCECCKICAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVG-----------CVLDGVRYTNGESFQPNCRYNCTCIDGTVGCTPLCL----SPRPPRLWCRQPRHV--RVPGQCCEQWVCDDD---ARRPRQTALLDTRAFAASGAVEQRYENC--IAYTSPWSPCSTTCGLGISTRISNVNARCWPEQESRLCNLRPCDVDIQ-----LHIK--------AGKKCLAVYQPEEAT-NFTLAGCVSTRTYRPKYCGVCTDNRCCIPYKSKTISVDFQCPEGPGFSRQVLWINACFCN 343
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Mouse
Match: Ccn1 (cellular communication network factor 1 [Source:MGI Symbol;Acc:MGI:88613])

HSP 1 Score: 110.153 bits (274), Expect = 2.727e-26
Identity = 93/336 (27.68%), Postives = 140/336 (41.67%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSN--NGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLG-------------------VLSDQLVTF-----LRKRKIYXXXXXXXXXXXXXKLQA----DTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKV-EAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            D CGCC+ C + + E C     CDHT+ L C    SS    GIC+           ++  + C +N  +YQ+   F  +C+H+C C DG V C  LC    Q    P   CP+   L+  S  QCC EW C  D +                      +++L+       L++  ++           +   Q      T WS+CSK CG GISTR + +N  C  V + R C  R C   V  ++ K  K  +   +  P                 F+   C S +K+RP++CG+C    CC P+ ++T ++ F C D     +    I+ C C
Sbjct:   48 DGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICR----------AQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLC---PQELSLPNLGCPN-PRLVKVS-GQCCEEWVCDEDSIKDSLDDQDDLLGLDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLFNPLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPV---------------RFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFRCEDGEMFSKNVMMIQSCKC 353
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Mouse
Match: Ccn2 (cellular communication network factor 2 [Source:MGI Symbol;Acc:MGI:95537])

HSP 1 Score: 108.227 bits (269), Expect = 2.824e-26
Identity = 71/223 (31.84%), Postives = 96/223 (43.05%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQ 908
             D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C            +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   +N+K+ 
Sbjct:   50 LDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKI---------GVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANC---LVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLE---ENIKVH 252
[Close]
BLAST of Cellular communication network factor 4 vs. UniProt/SwissProt
Match: sp|O18739|CCN2_BOVIN (CCN family member 2 OS=Bos taurus OX=9913 GN=CCN2 PE=2 SV=2)

HSP 1 Score: 134.035 bits (336), Expect = 1.961e-34
Identity = 107/349 (30.66%), Postives = 145/349 (41.55%), Query Frame = 3 
Query:  126 CHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQ-----FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            C F++ L +     SSQ   +C+  C         CP       D CGCC+ C + + E C   + CD  + LFC     +N  I         G     +   C+F G VYQS   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       +    +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T  P  S  I+  L            C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   11 CAFVLLLALCSRPASSQ---DCSAPCQCPAGPAPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDPHKGLFCDFGSPANRKI---------GVCTAKDGAPCVFGGTVYQSGESFQSSCKYQCTCLDGSVGCVPLC-SVDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMIRANC---LVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRT--PKISKPIKFELSG----------CTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCAC 325
[Close]
BLAST of Cellular communication network factor 4 vs. UniProt/SwissProt
Match: sp|O19113|CCN2_PIG (CCN family member 2 OS=Sus scrofa OX=9823 GN=CCN2 PE=2 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 5.798e-34
Identity = 103/349 (29.51%), Postives = 146/349 (41.83%), Query Frame = 3 
Query:  126 CHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQ-----FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            C F++ L +     S Q   +C+  C     +   CP       D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       +    +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + +   K ++              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   11 CAFVLLLALCSRPASGQ---DCSGQCQCAAGKRRACPAGVSLVLDGCGCCRLCAKQLGELCTERDPCDPHKGLFCDFGSPANRKI---------GVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANC---LVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKISKPVKFELS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCAC 325
[Close]
BLAST of Cellular communication network factor 4 vs. UniProt/SwissProt
Match: sp|Q9R1E9|CCN2_RAT (CCN family member 2 OS=Rattus norvegicus OX=10116 GN=Ccn2 PE=2 SV=1)

HSP 1 Score: 131.724 bits (330), Expect = 1.398e-33
Identity = 95/306 (31.05%), Postives = 131/306 (42.81%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       +    +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + A   K ++              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   49 LDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKI---------GVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDRTVVGPALAAYRLEDTFGPDPTMMRANC---LVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKIAKPVKFELS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCAC 323
[Close]
BLAST of Cellular communication network factor 4 vs. UniProt/SwissProt
Match: sp|P29279|CCN2_HUMAN (CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2)

HSP 1 Score: 131.724 bits (330), Expect = 1.677e-33
Identity = 98/306 (32.03%), Postives = 131/306 (42.81%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   CIF G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C       +    +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T  P  S  I+  L            C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   51 LDGCGCCRVCAKQLGELCTERDPCDPHKGLFCHFGSPANRKI---------GVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANC---LVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRT--PKISKPIKFELSG----------CTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCAC 325
[Close]
BLAST of Cellular communication network factor 4 vs. UniProt/SwissProt
Match: sp|P29268|CCN2_MOUSE (CCN family member 2 OS=Mus musculus OX=10090 GN=Ccn2 PE=2 SV=3)

HSP 1 Score: 130.954 bits (328), Expect = 2.577e-33
Identity = 95/306 (31.05%), Postives = 130/306 (42.48%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   + CD  + LFC     +N  I         G     +   C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   +L      +CC EW C            +   R    +          C   L   T WS CSK CGMGISTR + +N  C    Q R CM R C   +E   K  K ++C  T + A   K ++              C S + +R +FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   50 LDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKI---------GVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLC-SMDVRLPSPDCPFPRRVKL----PGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANC---LVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIK--KGKKCIRTPKIAKPVKFELS------------GCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCAC 324
[Close]
BLAST of Cellular communication network factor 4 vs. TrEMBL
Match: A0A1I8H4Q5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 146.362 bits (368), Expect = 1.060e-36
Identity = 104/344 (30.23%), Postives = 157/344 (45.64%), Query Frame = 3 
Query:  162 LISSQKNINCNKTCSQCYKELIYCPQF-----DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQI----VLPNEGNENFSEIVCLSKRKFRPRFCGAC--FHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSKK 1160
            + + Q   +C + C +C+ +   C        D CGCC+ C R +GE CD    CD    L C  D S++   C+     +           C  NG VY+    F+ +CR+RC C DG V+C D+C    QS  PP S+C H + L+P    +CC+EW C N    V +       +  +  +N +              T WS CS  CG+G S+R + +N+ C  + + R CM  EC          ++ Q+C  T R      +      V    G    + + C S R ++P+FC  C    CC P+  KTK +EF+C D I R++ + WIK C C+ +
Sbjct:    6 VATGQTPFDCPRPC-RCFNQPPQCHAGVTAVRDGCGCCEVCARQLGEDCDERYPCDPAGDLVCARDPSTHVAFCRKRSGGLS----------CHVNGRVYRDGEAFNSTCRYRCLCQDGRVACSDVC--WHQSRQPPSSVCRH-SSLVPIP-GRCCKEWICDNTPAAVAATAAPASSKAGEGEDNDDGVV-----------TKWSACSTTCGVGQSSRLTNDNVECKTIRETRLCMMAEC-----VADPAVEEQRCRSTIRAERPMSLTYTEDQVSQTLGEGPATPVQCRSVRLWKPKFCSGCQRKRCCRPLKVKTKMVEFQCDDGIGRVRQWAWIKRCICTNR 318
[Close]
BLAST of Cellular communication network factor 4 vs. TrEMBL
Match: A0A0A7HRN4 (Connective tissue growth factor a OS=Megalobrama amblycephala OX=75352 GN=CTGFa PE=2 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 2.425e-36
Identity = 103/348 (29.60%), Postives = 155/348 (44.54%), Query Frame = 3 
Query:  114 VIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            +  LC   ++  V+Q+         C     QC   +   P  D CGCC+ C + +GE C   ++CD  + L+C+    SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  ++   P P    P   ++      +CC EW C + +        +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N+ C    Q R CM R C + +E   K  K ++C  T R +   K ++              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:    8 IALLCLTFLRWAVAQEC---SGQCLCPDVPPQCSPGVSLVP--DTCGCCRVCAKQLGELCTERDVCDPHKGLYCEYGSPSNRRI---------GVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDIRLPSPDCPMPRRVKV----PGKCCEEWVCDSPHQTTFVGSALAAYREEETYGPDPSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNLECRLEKQSRLCMVRPCESHLEE--KIRKGKKCIRTPRVSKPMKFEVS------------GCTTTKSYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCAC 319
[Close]
BLAST of Cellular communication network factor 4 vs. TrEMBL
Match: A0A4W4HFI5 (Uncharacterized protein OS=Electrophorus electricus OX=8005 GN=ccn2 PE=4 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 2.431e-36
Identity = 112/362 (30.94%), Postives = 157/362 (43.37%), Query Frame = 3 
Query:   90 MFKNVCFYVIF-LCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQ-----FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            MF      +IF LC  +    V+Q+         C+  C QC      CP       D CGCC+ C + +GE C   + CD  + LFC     SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  I+   P P    P   ++      +CC EW C + +        +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C + +E   K  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:    1 MFSGRSTRLIFVLCIALFSWAVAQE---------CSGEC-QCPDLHPQCPPGVSLVLDTCGCCRVCAKQLGELCTERDACDPHKGLFCDYGSPSNRRI---------GVCTARDGAPCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GIDVRLPSPDCPAPRRVKV----PGKCCEEWVCDSPHTNTFVGSALAAFREEETYGPDPSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEE--KIRKGKKCIRTPRVSKPMKFEIS------------GCTTTKAYRPKFCGVCTDGRCCTPHRTTTLPMEFKCPDGQVMKKQMMFIKTCAC 321
[Close]
BLAST of Cellular communication network factor 4 vs. TrEMBL
Match: A0A3B4CA12 (Cellular communication network factor 2a OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 145.591 bits (366), Expect = 2.869e-36
Identity = 106/357 (29.69%), Postives = 157/357 (43.98%), Query Frame = 3 
Query:   90 MFKNVCFYVI-FLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            MF  +   ++  LC       V+Q+        +C     QC   +   P  D CGCC+ C + +GE C   ++CD  + L+C     SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  ++   P P    P   ++      +CC EW C + +  +     +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C + +E   K  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:    1 MFSGMSLRLVSVLCFTFFSWVVAQECTG---QCHCPDVPPQCPPGVSLVP--DACGCCRVCAKQLGELCTERDVCDPHKGLYCDYGSPSNRRI---------GVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDVRLPSPDCPSPRRVKV----PGKCCEEWVCDSPHTTMFVGSALAAYREEETYGPDLSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEE--KIRKGKKCIRTPRVSKPMKFEIS------------GCTTTKAYRPKFCGVCTDGRCCTPHRTATLPVEFKCPDGQVMKKQMMFIKTCAC 321
[Close]
BLAST of Cellular communication network factor 4 vs. TrEMBL
Match: A0A4U5UM64 (Connective tissue growth factor CCN family member 2 Hypertrophic chondrocyte-specific protein 24 OS=Collichthys lucidus OX=240159 GN=D9C73_009835 PE=4 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 6.572e-36
Identity = 105/350 (30.00%), Postives = 154/350 (44.00%), Query Frame = 3 
Query:  108 FYVIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
              V FLC  +  + V Q+        +C  T  QC   +      D CGCC+ C + +GE C   +LCD  + L+C      N  I         G     +   C+F G VY+S   F  SC+++C C DG V C  LC +++   P P    P   ++      +CC EW C + Y        +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C +++E   +  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:    9 ILVPFLCIMLSYMAVGQEC---SGQCSCPSTPPQCSPGVSL--VLDGCGCCRVCAKQMGELCTEKDLCDPHKGLYCDFGAPINRRI---------GVCTARDGATCVFGGTVYKSGETFQSSCKYQCTCLDGAVGCVPLC-SMDVRLPSPDCPMPRRVKV----PGKCCEEWECDSPYRPTFMGSALAAYREEETYGPDPSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRDCRLEKQTRLCMVRPCESQLEQSIR--KGKKCIRTPRLSKPMKFEIS------------GCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPDGQVMKKHMMFIKSCAC 322
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Cavefish
Match: ccn2a (cellular communication network factor 2 [Source:NCBI gene;Acc:103034824])

HSP 1 Score: 142.124 bits (357), Expect = 2.516e-38
Identity = 96/306 (31.37%), Postives = 138/306 (45.10%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   ++CD  + LFC     SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  ++   P P    P   ++      +CC EW C +          +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C + +E   +  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   47 LDACGCCRVCAKQLGELCTERDVCDPHKGLFCDYGSPSNRRI---------GVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDVRLPSPDCPSPRRVKV----PGKCCEEWVCDSPQSNTFVGSALAAYREEETYGPDLSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEE--RIRKGKKCIRTPRVSKPMKFEIS------------GCTTTKAYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCAC 321
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Cavefish
Match: ccn2a (cellular communication network factor 2 [Source:NCBI gene;Acc:103034824])

HSP 1 Score: 142.124 bits (357), Expect = 3.078e-38
Identity = 96/306 (31.37%), Postives = 138/306 (45.10%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   ++CD  + LFC     SN  I         G     +   C+F GMVY+S   F  SC+++C C DG V C  LC  ++   P P    P   ++      +CC EW C +          +   R+ + Y    +   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C + +E   +  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   64 LDACGCCRVCAKQLGELCTERDVCDPHKGLFCDYGSPSNRRI---------GVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDVRLPSPDCPSPRRVKV----PGKCCEEWVCDSPQSNTFVGSALAAYREEETYGPDLSMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEE--RIRKGKKCIRTPRVSKPMKFEIS------------GCTTTKAYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCAC 338
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Cavefish
Match: ccn1l1 (cellular communication network factor 1, like 1 [Source:ZFIN;Acc:ZDB-GENE-050417-136])

HSP 1 Score: 124.02 bits (310), Expect = 2.098e-31
Identity = 94/344 (27.33%), Postives = 134/344 (38.95%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSN--NGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAEL---------IPSSDNQCCREWSCKNDYLGVLSDQLV-------TFLRKRKIYXXXXXXXXXXXXXKLQA------------------DTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSK 1157
             D CGCC+ C R   + C     CDH + L C +    +   G+C+           E   + C  +G VYQ    F  SC HRC C DG+V C              I +CPH   L         + +   +CC+EW C +D      D  V       T L   ++        +       Q                    T WS CS  CGMG+S+R + +N  C  V + R C  REC   +   PK  K ++C  T RP     I                C + R++RPR CG+C    CC P  + T ++ F C      I+ + WI+ C+C++
Sbjct:   46 LDSCGCCRLCARQFNQDCSPTEPCDHIKGLRCHLGAGGDPQRGLCR----------AEAQGRPCELDGRVYQHGEDFQPSCEHRCSCMDGVVGC--------------IPLCPHHVPLPDWRCTRPRLSTLPGRCCQEWVCDDDNRIDEEDLSVDPTPYDQTDLTGNELLEMAPAPWDSSAGAPYQEWTSTSQSHALVPGTCFLQTTDWSPCSSTCGMGVSSRVTNSNAECRLVKETRLCRIRECSESLVQAPK--KGKKCQRTTRPHRPVPITFA------------GCSTVRRYRPRSCGSCVDGRCCTPSQTHTVQLRFFCPQGDTFIRNFMWIQQCSCTR 351
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Cavefish
Match: ccn1 (cellular communication network factor 1 [Source:NCBI gene;Acc:103041941])

HSP 1 Score: 123.635 bits (309), Expect = 2.266e-31
Identity = 96/332 (28.92%), Postives = 144/332 (43.37%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDES--SNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVT-----------FLRKRKIYXXXXXXXXXXXXXKLQADT-------------PWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D CGCC+ C R + E C     CDHT+ L C    S  +  GIC+           ++  + C +N  +YQ+   F  +C+H+C C DG V C  LC   ++ + P +         +P    QCC EW C +      SD+L                + ++  N+      L   ++Q +T             PWS+CSK CG GISTR + NN  C  V + R C  R C     +  K  K ++C  T + A   K            F+   C S +K+RP++CG+C    CC P  ++T R++F C D     +    I+ C C+
Sbjct:   44 DACGCCKVCARQLNEDCSKTEPCDHTKGLECNFGASFGAARGICR----------AKSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCP--QELSLPTLGCSNPRLVKVP---GQCCEEWVCDDSAQLDPSDKLFGKEIMPDETENDLTNRNELVANVKAGLKSLPAFRVQPETHMFGSQKCIVQTTPWSQCSKSCGTGISTRVTNNNAECKLVKESRICEVRPCTQSPYSSLK--KGKKCNRTKKSAQPVK------------FTFAGCSSLKKYRPKYCGSCVDGRCCSPQQTRTVRVKFRCEDGETFNKNVMLIETCKCT 346
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Cavefish
Match: ccn1 (cellular communication network factor 1 [Source:NCBI gene;Acc:103041941])

HSP 1 Score: 123.25 bits (308), Expect = 2.846e-31
Identity = 98/332 (29.52%), Postives = 143/332 (43.07%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDES--SNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVT-----------FLRKRKIYXXXXXXXXXXXXXKLQADT-------------PWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D CGCC+ C R + E C     CDHT+ L C    S  +  GIC+           ++  + C +N  +YQ+   F  +C+H+C C DG V C  LC   E S P      P   ++      QCC EW C +      SD+L                + ++  N+      L   ++Q +T             PWS+CSK CG GISTR + NN  C  V + R C  R C     +  K  K ++C  T + A   K            F+   C S +K+RP++CG+C    CC P  ++T R++F C D     +    I+ C C+
Sbjct:   45 DACGCCKVCARQLNEDCSKTEPCDHTKGLECNFGASFGAARGICR----------AKSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQ-ELSLPTLGCSNPRLVKV----PGQCCEEWVCDDSAQLDPSDKLFGKEIMPDETENDLTNRNELVANVKAGLKSLPAFRVQPETHMFGSQKCIVQTTPWSQCSKSCGTGISTRVTNNNAECKLVKESRICEVRPCTQSPYSSLK--KGKKCNRTKKSAQPVK------------FTFAGCSSLKKYRPKYCGSCVDGRCCSPQQTRTVRVKFRCEDGETFNKNVMLIETCKCT 347
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Sea Lamprey
Match: ccn1l2 (cellular communication network factor 1, like 2 [Source:ZFIN;Acc:ZDB-GENE-060404-5])

HSP 1 Score: 132.88 bits (333), Expect = 2.357e-35
Identity = 105/376 (27.93%), Postives = 154/376 (40.96%), Query Frame = 3 
Query:  144 LDVSQDLISSQKNINCNKTCSQCYKELIYCPQF-----DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQ--IDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKN---------------------------DYLGVLSDQLVTFL-RKRKIYXXXXXXXXXXXXXK---LQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            L V  +L SS    +C   C QC   L  C        D CGCC+ C R   + C     CD  + L C    D ++  GIC+           ++  + C +NG +YQ    F  +C+H C C DG+V C  LC   ++ A P   +       +     +CC EW+C +                           D   V S++L+ F  RK KI      ++      K   +   T WS+CSK CGMGISTR + +N  C  V + R C  R C ++  +     K ++C  T R     +            ++   C S RKF+P++CG C    CC P  + T R+ F C D     +   W++ C C
Sbjct:   15 LAVCVNLASS----SCPAQCPQCPASLPQCALGVSLVNDGCGCCKVCARQFNQDCSRSEPCDPLKGLECDSGADAAAERGICRA----------KSEGRTCDYNGKIYQHGESFQPNCKHACTCVDGVVGCMPLCP--QELAFPAARLAGCANPRLVKVPGRCCEEWTCDDAVAADSSEEDATSQGQSREEELADSLEDARSVESNELIVFTPRKHKILPAWRQHAFARLFKKPKCMVQTTEWSQCSKTCGMGISTRVTNDNSECKLVKETRLCEIRPCSSQAPSAANLKKGKKCNRTERAKKGLR------------YTYAGCTSVRKFKPKYCGGCVDGRCCTPDQTHTVRVRFRCDDGETLTKSMLWVESCRC 362
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Sea Lamprey
Match: ccn4a (cellular communication network factor 4a [Source:ZFIN;Acc:ZDB-GENE-070705-178])

HSP 1 Score: 107.457 bits (267), Expect = 3.234e-26
Identity = 85/311 (27.33%), Postives = 127/311 (40.84%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN---GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYREC-PNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGAC--FHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSK 1157
            D CGCC++C R  GE C   + CD+ R L+C           G+C Y+  +            C  NG  YQ+   F  SCR+RC C +G + C   C      + PP+  C     +  +   +CC  W C +D    +   +   L    ++ +         +N L   T WS CS+ CG+GISTR + +N  C    ++R C  R C  N   +I +    Q+   +  P     +++ L            C S   +  +FCG C    CC+P  + T   EF C D         WI  C C +
Sbjct:   70 DGCGCCKTCARQGGERCTEADTCDYHRGLYCDYSGDRPRYEIGVCAYIIGVG-----------CRLNGEHYQNGQTFQQSCRYRCTCVNGAIGCVPACT---HESRPPLVWCQRPRRV--AVPGKCCERWVC-DDIRAKIRKSVPKHL-ALAVFRDEREEDTLWRSNCLVQTTSWSPCSESCGLGISTRITNHNAACSMSRERRLCYVRPCETNGTHSIREGRSCQREYRSRHP-----VRLELSG----------CTSIVSYLFKFCGGCRDGRCCDPNRTATISAEFSCPDGTRTKWQLMWINSCRCHR 347
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Sea Lamprey
Match: ccn2b (cellular communication network factor 2b [Source:ZFIN;Acc:ZDB-GENE-070705-82])

HSP 1 Score: 97.8265 bits (242), Expect = 8.299e-23
Identity = 86/328 (26.22%), Postives = 130/328 (39.63%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQI--DESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLC-QAIEQSAPPPISICPHGAELIPSSDNQCCREWSCK--------------------NDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
            D CGCC+ C + +G+ C   + CD  R L+C    D     G+C   + +            C   G +Y +  RF  SC++RC C  G + C  LC Q +    P P  +       +P    +CC EW C                     N  +  L        R+ + Y     +    C  +    T WS CS  CG+G+S+R + +N  C    Q R C  R C   ++ + K  K ++C  T + A   +++          FS   C S + FRP++CG C    CC P  + T  ++F C       +    I  CAC
Sbjct:   52 DGCGCCKVCAKQLGDVCTEADSCDPHRGLYCAFSTDLQIRIGVCSARDGVP-----------CELGGTMYLNGERFEPSCKYRCTCDRG-IGCVPLCAQDVRLHCPHPRHV------KLP---GKCCEEWVCDGRKEPNSTPLGGFALPERRTNARIAFLPSSPGAAYRQEETYGPDPESVRDNCIVQT---TEWSACSHTCGLGVSSRVTNDNRQCRLERQTRLCTVRPCDVPLQDVIK--KGKKCMRTPKAAKPKRLE----------FSG--CTSVKTFRPKYCGQCTDGRCCTPHHTSTASVDFRCPGGERLRRQVMVIHTCAC 341
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008849.1 (pep scaffold:Pmarinus_7.0:GL483045:6966:12294:1 gene:ENSPMAG00000008003.1 transcript:ENSPMAT00000008849.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.929 bits (154), Expect = 2.364e-12
Identity = 46/174 (26.44%), Postives = 64/174 (36.78%), Query Frame = 3 
Query:  417 KICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSC-----------------KNDYLGVLSDQLVTFLRKRK-------IYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYREC 866
            + C F G++Y+   RF + C   C C  G ++C   C   E     P   CP     +P +  +CC EW C                  +D +    D+    L   K               +     +     + WS CS+ CG GISTR ST N  C    Q R C+ R C
Sbjct:    1 RSCEFGGVLYRDGERFHMGCEQYCSCRAGGLACVPACPQSEML---PSPSCPE-PRRVPPTPGKCCHEWVCGQPEAAGTGKRTREVLGGHDAMAGTGDRATLTLSPGKGQCVCTLTGAPKLIYTTVPEPHSYGDSSEWSACSRSCGAGISTRVSTENPRCRMERQSRACVVRPC 170
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Medaka
Match: ccn2a (cellular communication network factor 2 [Source:NCBI gene;Acc:101163784])

HSP 1 Score: 141.739 bits (356), Expect = 3.481e-38
Identity = 99/308 (32.14%), Postives = 143/308 (46.43%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDE--SSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D CGCC+ C + +GE C   ++CD  + LFC I    S   G+C   E              C+F G VY+S   F  SC+++C C DG + C  LC +++   P P    P   ++      +CC EW C + Y   L    ++  R+ + Y    N   + C   L   T WS CSK CG+GISTR + +N  C    Q R CM R C +++E   K  K ++C  T R +   K +I              C + + +RP+FCG C    CC P  + T  +EF+C D     +   +IK CAC
Sbjct:   48 LDGCGCCRVCAKQMGELCTDKDVCDPHKNLFCDIGAPISRRIGVCTAREG-----------ASCVFGGTVYKSGETFQSSCKYQCTCMDGAMGCVPLC-SMDIRLPSPDCPMPRRVKV----PGKCCEEWECDSPYKDTLLGPALSAFREEETYGPDPNMMRENC---LVQTTEWSACSKTCGLGISTRVTNDNHECRLEKQTRLCMVRPCESQMEQSIK--KGKKCIRTPRVSKPMKFEIS------------GCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPDGQVMKKHMMFIKSCAC 322
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Medaka
Match: ccn1 (cellular communication network factor 1 [Source:NCBI gene;Acc:101157527])

HSP 1 Score: 123.635 bits (309), Expect = 2.627e-31
Identity = 110/381 (28.87%), Postives = 158/381 (41.47%), Query Frame = 3 
Query:  117 IFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQ-----FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDES----SNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKN----DYLGVL--SDQLVTFLRKRKIYXXXXXXXXXXXXXKLQA------------------DTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            + + H ++    S  L+ S    +C   C +C  E+  C        D C CC+ C R + E C     CDHT+ L C    S    +  GIC+           ++  + C +N  +YQ+   F  +C+H+C C DG V C  LC   E S P      P   ++      QCC EW C++    D L  +   D+L   L K     N      K     L A                   TPWS+CSK CG GISTR + NN  C  V + R C  R C     A  K  K ++C  T + +   K            F+   C S +K+RPR+CG+C    CC P  ++T +++F C D     +    I+ C C+
Sbjct:    1 MLMLHSLVFFIGSLTLVLSYPPSSCPSVC-ECQVEMPKCAPGVSVVLDGCNCCRVCARQLNEDCSLTEPCDHTKGLECNFGASLAAATTRGICR----------AKSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCVPLCPQ-ELSLPNLGCANPRLVKVA----GQCCEEWVCEDGKETDILEKIFGKDKLTEELEKDLTNRNELIAIVKGGLKTLPAYRPQPEVYMFDSPKCIVQTTPWSQCSKSCGTGISTRVTNNNNECKLVRETRLCEVRPCTQSSYASLK--KGKKCNRTKKSSQPVK------------FTYAGCSSVKKYRPRYCGSCVDGRCCSPHDTRTIQVKFRCEDGETFYKKTMMIETCKCT 351
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Medaka
Match: ccn4a (cellular communication network factor 4 [Source:NCBI gene;Acc:101171259])

HSP 1 Score: 117.087 bits (292), Expect = 4.462e-29
Identity = 90/311 (28.94%), Postives = 132/311 (42.44%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN-----GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D C CC++C R +GE C+  + CD+ + L+C  D SS+      G+C YM               C  NG++Y++   F  SC+++C C +G + C  LC   +    PP   C +   +      QCC +W C     G  +         R     +   +    NN +   T WS CSK CG G+S R S  N  C  V + R C  R C   +              TN      K   +   +   N +   C SK+++RP++CG C    CC P  SKT  +EFEC +         WI+ C C+
Sbjct:   67 DGCECCKACARQVGEVCNEADTCDYHKGLYC--DYSSDKPRYEKGVCAYMVGTG-----------CEHNGVIYRNGQSFQPSCKYQCVCVNGAIGCVALCSESQ----PPRVWCQNPRRI--KVRGQCCEKWICDEPRRGRKA-------APRHAVEALPAKNRSWDNNCISQTTSWSPCSKTCGRGLSLRISNANDQCQMVKESRLCNLRPCEVDI--------------TNHIKPGKKCLNIYREDQPLNLTLSGCTSKKQYRPKYCGVCTDERCCIPYKSKTIDVEFECPNGAGFTWKMMWIQACFCN 337
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Medaka
Match: ccn4a (cellular communication network factor 4 [Source:NCBI gene;Acc:101171259])

HSP 1 Score: 117.087 bits (292), Expect = 4.462e-29
Identity = 90/311 (28.94%), Postives = 132/311 (42.44%), Query Frame = 3 
Query:  243 DECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNN-----GICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACS 1154
            D C CC++C R +GE C+  + CD+ + L+C  D SS+      G+C YM               C  NG++Y++   F  SC+++C C +G + C  LC   +    PP   C +   +      QCC +W C     G  +         R     +   +    NN +   T WS CSK CG G+S R S  N  C  V + R C  R C   +              TN      K   +   +   N +   C SK+++RP++CG C    CC P  SKT  +EFEC +         WI+ C C+
Sbjct:   67 DGCECCKACARQVGEVCNEADTCDYHKGLYC--DYSSDKPRYEKGVCAYMVGTG-----------CEHNGVIYRNGQSFQPSCKYQCVCVNGAIGCVALCSESQ----PPRVWCQNPRRI--KVRGQCCEKWICDEPRRGRKA-------APRHAVEALPAKNRSWDNNCISQTTSWSPCSKTCGRGLSLRISNANDQCQMVKESRLCNLRPCEVDI--------------TNHIKPGKKCLNIYREDQPLNLTLSGCTSKKQYRPKYCGVCTDERCCIPYKSKTIDVEFECPNGAGFTWKMMWIQACFCN 337
[Close]
BLAST of Cellular communication network factor 4 vs. Ensembl Medaka
Match: CCN3 (cellular communication network factor 3 [Source:NCBI gene;Acc:101174891])

HSP 1 Score: 108.227 bits (269), Expect = 6.505e-26
Identity = 84/310 (27.10%), Postives = 133/310 (42.90%), Query Frame = 3 
Query:  240 FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQ--IDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSC--KNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACF--HCCEPVSSKTKRIEFECSDKINRIQMYEWIKICAC 1151
             D+C CC  C    G+ C  +  CD  + L C   ++     G+C             N    C+ +G VYQ+   F  SC+++C C DG ++C   C  ++   P P    P    +      +CC +W C  + +   + S  +  F ++  +  N  + S       +   T W  CS+ CGMG+STR +  N  C  V Q R CM R C    E      ++ Q  P+ R A   + Q  +  +   + +   C S + ++PRFCG C    CC P  +KT  +EF+C++     +    I  C C
Sbjct:   61 LDDCACCLVCAAQKGQVCSEMKPCDTRKGLQCDYSVNTHKRTGVCAV-----------NAGNACVLDGSVYQNGQTFFPSCKYQCMCHDGQIACVPRCN-LDIMLPGPDCPMPRRVHV----PGECCEKWVCGLRAEASALGSLAMAAFRQEETVSLNSWDPSLNC----IVQTTEWGACSETCGMGVSTRVTNKNDNCEMVKQSRLCMIRPCEGLQE------QLTQLPPSQRGA---RCQRTVRRDKAIHLTYKNCTSVQAYKPRFCGFCTDSRCCTPHRTKTALVEFQCAEGKTTRRPVMVILTCVC 341
[Close]
BLAST of Cellular communication network factor 4 vs. Planmine SMEST
Match: SMESG000036248.1 (SMESG000036248.1)

HSP 1 Score: 693.345 bits (1788), Expect = 0.000e+0
Identity = 357/358 (99.72%), Postives = 357/358 (99.72%), Query Frame = 3 
Query:   90 MFKNVCFYVIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYXXXXXXXXXXXXXKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACFHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSKKM 1163
            MFKNVCFYVIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYNNINNNSNKLCNNKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQ CTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACFHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSKKM
Sbjct:    1 MFKNVCFYVIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQFDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLIKGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIEQSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRKIYNNINNNSNKLCNNKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQKRFCMYRECPNKVEAIPKNLKIQICTPTNRPANSSKIQIVLPNEGNENFSEIVCLSKRKFRPRFCGACFHCCEPVSSKTKRIEFECSDKINRIQMYEWIKICACSKKM 358
The following BLAST results are available for this feature:
BLAST of Cellular communication network factor 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CCN23.493e-3432.03cellular communication network factor 2 [Source:HG... [more]
CCN38.175e-3230.19cellular communication network factor 3 [Source:HG... [more]
CCN41.740e-3027.30cellular communication network factor 4 [Source:HG... [more]
CCN12.940e-2729.20cellular communication network factor 1 [Source:HG... [more]
CCN64.221e-2030.00cellular communication network factor 6 [Source:HG... [more]
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BLAST of Cellular communication network factor 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cellular communication network factor 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cellular communication network factor 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ccn2a6.370e-3831.37cellular communication network factor 2a [Source:Z... [more]
ccn2a6.370e-3831.37cellular communication network factor 2a [Source:Z... [more]
ccn13.713e-3128.35cellular communication network factor 1 [Source:ZF... [more]
ccn4b6.185e-3128.24cellular communication network factor 4b [Source:Z... [more]
ccn2b1.333e-3028.53cellular communication network factor 2b [Source:Z... [more]
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BLAST of Cellular communication network factor 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ccn21.949e-3431.92cellular communication network factor 2 [Source:NC... [more]
ccn22.513e-3431.92cellular communication network factor 2 [Source:NC... [more]
ccn24.539e-3431.92cellular communication network factor 2 [Source:NC... [more]
CCN41.766e-2829.21cellular communication network factor 4 [Source:NC... [more]
CCN64.352e-2731.03cellular communication network factor 6 [Source:NC... [more]
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BLAST of Cellular communication network factor 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ccn23.684e-3431.05cellular communication network factor 2 [Source:MG... [more]
Ccn32.904e-3130.00cellular communication network factor 3 [Source:MG... [more]
Ccn47.144e-2827.83cellular communication network factor 4 [Source:MG... [more]
Ccn12.727e-2627.68cellular communication network factor 1 [Source:MG... [more]
Ccn22.824e-2631.84cellular communication network factor 2 [Source:MG... [more]
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BLAST of Cellular communication network factor 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O18739|CCN2_BOVIN1.961e-3430.66CCN family member 2 OS=Bos taurus OX=9913 GN=CCN2 ... [more]
sp|O19113|CCN2_PIG5.798e-3429.51CCN family member 2 OS=Sus scrofa OX=9823 GN=CCN2 ... [more]
sp|Q9R1E9|CCN2_RAT1.398e-3331.05CCN family member 2 OS=Rattus norvegicus OX=10116 ... [more]
sp|P29279|CCN2_HUMAN1.677e-3332.03CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN... [more]
sp|P29268|CCN2_MOUSE2.577e-3331.05CCN family member 2 OS=Mus musculus OX=10090 GN=Cc... [more]
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BLAST of Cellular communication network factor 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8H4Q51.060e-3630.23Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A0A7HRN42.425e-3629.60Connective tissue growth factor a OS=Megalobrama a... [more]
A0A4W4HFI52.431e-3630.94Uncharacterized protein OS=Electrophorus electricu... [more]
A0A3B4CA122.869e-3629.69Cellular communication network factor 2a OS=Pygoce... [more]
A0A4U5UM646.572e-3630.00Connective tissue growth factor CCN family member ... [more]
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BLAST of Cellular communication network factor 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ccn2a2.516e-3831.37cellular communication network factor 2 [Source:NC... [more]
ccn2a3.078e-3831.37cellular communication network factor 2 [Source:NC... [more]
ccn1l12.098e-3127.33cellular communication network factor 1, like 1 [S... [more]
ccn12.266e-3128.92cellular communication network factor 1 [Source:NC... [more]
ccn12.846e-3129.52cellular communication network factor 1 [Source:NC... [more]
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BLAST of Cellular communication network factor 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ccn1l22.357e-3527.93cellular communication network factor 1, like 2 [S... [more]
ccn4a3.234e-2627.33cellular communication network factor 4a [Source:Z... [more]
ccn2b8.299e-2326.22cellular communication network factor 2b [Source:Z... [more]
ENSPMAT00000008849.12.364e-1226.44pep scaffold:Pmarinus_7.0:GL483045:6966:12294:1 ge... [more]
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BLAST of Cellular communication network factor 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cellular communication network factor 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cellular communication network factor 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ccn2a3.481e-3832.14cellular communication network factor 2 [Source:NC... [more]
ccn12.627e-3128.87cellular communication network factor 1 [Source:NC... [more]
ccn4a4.462e-2928.94cellular communication network factor 4 [Source:NC... [more]
ccn4a4.462e-2928.94cellular communication network factor 4 [Source:NC... [more]
CCN36.505e-2627.10cellular communication network factor 3 [Source:NC... [more]
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BLAST of Cellular communication network factor 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000036248.10.000e+099.72SMESG000036248.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004083 ID=SMED30004083|Name=Cellular communication network factor 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1235bp
GAAATATCTGATTCGCCCAATCACAATCAATTACATTAGATTAAATTTAT
CCTAAAAACAAAGTGATATTCATTGTTTCTTAATCAGAAATGTTTAAAAA
TGTTTGTTTTTATGTTATTTTTCTATGTCATTTCATGATAAAATTGGATG
TCTCCCAGGATTTAATTTCCTCTCAAAAGAATATTAATTGCAACAAAACC
TGCTCTCAATGCTATAAAGAATTAATTTATTGCCCTCAGTTTGATGAGTG
TGGATGCTGTCAATCATGTCTTAGACTTATTGGAGAATTCTGTGACGCTG
TCAATCTCTGTGACCATACAAGGCAGCTATTCTGCCAAATTGACGAATCA
TCAAATAATGGAATTTGTAAATACATGGAAAATTTGATTAAAGGTAGTTA
TGAAGAAAACAATGAAAAAATTTGCATATTCAATGGAATGGTTTATCAGT
CCTCAGTCCGATTCTCCGTTTCCTGTAGACATCGTTGCCAATGCACAGAT
GGCTTAGTTTCCTGTCAAGATTTGTGTCAAGCAATTGAACAAAGTGCACC
CCCGCCAATTTCAATTTGTCCGCATGGAGCTGAATTGATTCCTTCAAGCG
ACAATCAGTGCTGTCGAGAATGGTCGTGTAAAAATGATTATTTGGGGGTT
TTATCAGACCAACTTGTGACTTTTTTAAGAAAACGAAAAATTTATAATAA
TATTAATAATAATTCAAATAAACTATGCAACAACAAACTTCAAGCTGACA
CTCCTTGGTCAAAATGCAGTAAAAAATGCGGAATGGGAATTTCCACGAGA
ACATCAACGAATAATATTCTATGTGTAAATGTAACCCAGAAAAGATTTTG
TATGTATCGCGAATGCCCGAATAAAGTTGAAGCAATTCCGAAGAACTTGA
AAATCCAACAATGTACTCCAACAAATCGACCGGCAAATTCCTCGAAAATT
CAAATTGTTTTACCAAATGAAGGAAATGAAAACTTTTCCGAAATTGTGTG
CTTAAGTAAGCGAAAGTTCCGTCCAAGATTCTGTGGGGCCTGTTTTCATT
GTTGTGAGCCGGTTTCATCAAAAACGAAAAGAATTGAGTTTGAATGCTCT
GACAAAATCAACCGAATTCAGATGTACGAATGGATTAAAATTTGTGCCTG
TTCAAAAAAAATGTGTTCATGATTTATTTATTCAATTTATTTTTTAATCA
TTTGTTTTTGAAATAAACATTTATGTCACTTTTGG
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protein sequence of SMED30004083-orf-1

>SMED30004083-orf-1 ID=SMED30004083-orf-1|Name=SMED30004083-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=361bp
MFKNVCFYVIFLCHFMIKLDVSQDLISSQKNINCNKTCSQCYKELIYCPQ
FDECGCCQSCLRLIGEFCDAVNLCDHTRQLFCQIDESSNNGICKYMENLI
KGSYEENNEKICIFNGMVYQSSVRFSVSCRHRCQCTDGLVSCQDLCQAIE
QSAPPPISICPHGAELIPSSDNQCCREWSCKNDYLGVLSDQLVTFLRKRK
IYNNINNNSNKLCNNKLQADTPWSKCSKKCGMGISTRTSTNNILCVNVTQ
KRFCMYRECPNKVEAIPKNLKIQQCTPTNRPANSSKIQIVLPNEGNENFS
EIVCLSKRKFRPRFCGACFHCCEPVSSKTKRIEFECSDKINRIQMYEWIK
ICACSKKMCS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0001649osteoblast differentiation
GO:0030177positive regulation of Wnt signaling pathway
GO:0030316osteoclast differentiation
GO:0032331negative regulation of chondrocyte differentiation
GO:0042593glucose homeostasis
GO:0045599negative regulation of fat cell differentiation
GO:0045669positive regulation of osteoblast differentiation
GO:0050707regulation of cytokine secretion
GO:0050729positive regulation of inflammatory response
GO:0060348bone development
GO:0090303positive regulation of wound healing
GO:0001558regulation of cell growth
Vocabulary: cellular component
TermDefinition
GO:0005615extracellular space
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005576extracellular region
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000025nervous system
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036383TSP1_rpt_sf
IPR000867IGFBP-like
IPR006207Cys_knot_C
IPR001007VWF_dom
IPR000884TSP1_rpt
IPR009030Growth_fac_rcpt_cys_sf
Vocabulary: molecular function
TermDefinition
GO:0005520insulin-like growth factor binding
GO:0005515protein binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000867Insulin-like growth factor-binding protein, IGFBPSMARTSM00121IB_2coord: 32..95
e-value: 0.0031
score: 15.6
IPR000867Insulin-like growth factor-binding protein, IGFBPPROSITEPS51323IGFBP_N_2coord: 34..96
score: 9.037
IPR001007VWFC domainSMARTSM00214vwccoord: 112..180
e-value: 6.4E-8
score: 42.3
IPR001007VWFC domainPROSITEPS50184VWFC_2coord: 110..181
score: 8.688
IPR006207Cystine knot, C-terminalSMARTSM00041CT_3coord: 292..360
e-value: 0.0014
score: 19.9
IPR006207Cystine knot, C-terminalPROSITEPS01225CTCK_2coord: 275..360
score: 10.03
IPR000884Thrombospondin type-1 (TSP1) repeatSMARTSM00209TSP1_2coord: 217..260
e-value: 4.2E-4
score: 29.6
IPR036383Thrombospondin type-1 (TSP1) repeat superfamilyGENE3DG3DSA:2.20.100.10coord: 196..265
e-value: 7.5E-6
score: 27.6
IPR036383Thrombospondin type-1 (TSP1) repeat superfamilySUPERFAMILYSSF82895TSP-1 type 1 repeatcoord: 219..255
NoneNo IPR availablePANTHERPTHR11348CONNECTIVE TISSUE GROWTH FACTOR-RELATEDcoord: 19..360
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..22
score: 0.611
IPR009030Growth factor receptor cysteine-rich domain superfamilySUPERFAMILYSSF57184Growth factor receptor domaincoord: 36..96