Innexin
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003995 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Innexin vs. Ensembl Celegans
Match: eat-5 (Innexin eat-5 [Source:UniProtKB/Swiss-Prot;Acc:Q27295]) HSP 1 Score: 60.8474 bits (146), Expect = 1.105e-11 Identity = 29/60 (48.33%), Postives = 39/60 (65.00%), Query Frame = 3 Query: 210 SQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 S S K R DD DRLNY YS+L+++ +T RQ VG P+QCW+P +FT+ WE+Y Sbjct: 6 SMFSMVKPRLDDLGTDRLNYYYSTLIIMGMSLTITARQYVGSPLQCWVPAQFTKAWEQYA 65
BLAST of Innexin vs. Ensembl Celegans
Match: eat-5 (Innexin eat-5 [Source:UniProtKB/Swiss-Prot;Acc:Q27295]) HSP 1 Score: 60.8474 bits (146), Expect = 1.105e-11 Identity = 29/60 (48.33%), Postives = 39/60 (65.00%), Query Frame = 3 Query: 210 SQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 S S K R DD DRLNY YS+L+++ +T RQ VG P+QCW+P +FT+ WE+Y Sbjct: 6 SMFSMVKPRLDDLGTDRLNYYYSTLIIMGMSLTITARQYVGSPLQCWVPAQFTKAWEQYA 65
BLAST of Innexin vs. Ensembl Celegans
Match: inx-1 (Innexin [Source:UniProtKB/TrEMBL;Acc:Q17394]) HSP 1 Score: 60.4622 bits (145), Expect = 1.285e-11 Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 Query: 234 RFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 R DDD VD+LNY Y+S ++ +++ +Q VG PIQCW+P +FT WE+YT Sbjct: 16 RVDDDFVDKLNYHYTSAIIFAFAIIVSAKQYVGYPIQCWVPAQFTDAWEQYT 67
BLAST of Innexin vs. Ensembl Celegans
Match: inx-1 (Innexin [Source:UniProtKB/TrEMBL;Acc:Q17394]) HSP 1 Score: 60.4622 bits (145), Expect = 1.285e-11 Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 Query: 234 RFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 R DDD VD+LNY Y+S ++ +++ +Q VG PIQCW+P +FT WE+YT Sbjct: 16 RVDDDFVDKLNYHYTSAIIFAFAIIVSAKQYVGYPIQCWVPAQFTDAWEQYT 67
BLAST of Innexin vs. Ensembl Celegans
Match: inx-1 (Innexin [Source:UniProtKB/TrEMBL;Acc:Q17394]) HSP 1 Score: 60.077 bits (144), Expect = 1.800e-11 Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 Query: 234 RFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 R DDD VD+LNY Y+S ++ +++ +Q VG PIQCW+P +FT WE+YT Sbjct: 16 RVDDDFVDKLNYHYTSAIIFAFAIIVSAKQYVGYPIQCWVPAQFTDAWEQYT 67
BLAST of Innexin vs. UniProt/SwissProt
Match: sp|Q27295|EAT5_CAEEL (Innexin eat-5 OS=Caenorhabditis elegans OX=6239 GN=eat-5 PE=2 SV=1) HSP 1 Score: 60.8474 bits (146), Expect = 1.406e-10 Identity = 29/60 (48.33%), Postives = 39/60 (65.00%), Query Frame = 3 Query: 210 SQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 S S K R DD DRLNY YS+L+++ +T RQ VG P+QCW+P +FT+ WE+Y Sbjct: 6 SMFSMVKPRLDDLGTDRLNYYYSTLIIMGMSLTITARQYVGSPLQCWVPAQFTKAWEQYA 65
BLAST of Innexin vs. UniProt/SwissProt
Match: sp|Q03412|UNC7_CAEEL (Innexin unc-7 OS=Caenorhabditis elegans OX=6239 GN=unc-7 PE=1 SV=1) HSP 1 Score: 55.0694 bits (131), Expect = 1.357e-8 Identity = 26/52 (50.00%), Postives = 35/52 (67.31%), Query Frame = 3 Query: 234 RFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 R DDD VD+LNY Y++ +L L++ +Q VG PIQCW+P FT E+YT Sbjct: 136 RLDDDFVDKLNYYYTTTILASFALLVSAKQYVGFPIQCWVPATFTDAMEQYT 187
BLAST of Innexin vs. UniProt/SwissProt
Match: sp|O01393|UNC9_CAEEL (Innexin unc-9 OS=Caenorhabditis elegans OX=6239 GN=unc-9 PE=1 SV=1) HSP 1 Score: 54.6842 bits (130), Expect = 2.035e-8 Identity = 25/60 (41.67%), Postives = 39/60 (65.00%), Query Frame = 3 Query: 210 SQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 S V + DDD +D+LNY Y++ ++ + L++ +Q VG PIQCW+P FT+ E+YT Sbjct: 10 SAVKSIQFHVDDDIIDKLNYYYTTAIITVFAILVSAKQYVGFPIQCWVPATFTEPMEQYT 69
BLAST of Innexin vs. UniProt/SwissProt
Match: sp|Q19746|INX3_CAEEL (Innexin-3 OS=Caenorhabditis elegans OX=6239 GN=inx-3 PE=1 SV=2) HSP 1 Score: 51.2174 bits (121), Expect = 2.589e-7 Identity = 24/49 (48.98%), Postives = 33/49 (67.35%), Query Frame = 3 Query: 243 DDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 DDAVDRL+Y ++ LL +++ +Q VG IQCW+P EF GWE+Y Sbjct: 21 DDAVDRLSYVTTATLLAFFSIMVSCKQYVGSAIQCWMPMEFKGGWEQYA 69
BLAST of Innexin vs. UniProt/SwissProt
Match: sp|O61788|INX17_CAEEL (Innexin-17 OS=Caenorhabditis elegans OX=6239 GN=inx-17 PE=2 SV=1) HSP 1 Score: 51.2174 bits (121), Expect = 2.863e-7 Identity = 24/51 (47.06%), Postives = 33/51 (64.71%), Query Frame = 3 Query: 237 FDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 +D DA+DRL Y ++ LL S + +Q VG+ IQCW P++F GWEEY Sbjct: 16 YDSDAIDRLRYYFTVFLLTSSAFFIMAKQYVGQSIQCWAPKQFKGGWEEYA 66
BLAST of Innexin vs. TrEMBL
Match: Q2L6N1 (Innexin OS=Dugesia japonica OX=6161 GN=inx3 PE=2 SV=1) HSP 1 Score: 108.997 bits (271), Expect = 3.460e-25 Identity = 63/110 (57.27%), Postives = 79/110 (71.82%), Query Frame = 3 Query: 90 MSRGQFRDLVLTGDRRRSSFS----------GFGIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 MSRGQ RD++ G+ RR SFS G D+D TFF++L +L ++ +K+RFDDD VDRLNY+++ LLL M IGL+ IRQ VGKPIQCWIPQEFT+GWEEYT Sbjct: 1 MSRGQIRDILSAGEVRRPSFSHIVQSGSPVPGGDCSGDMDATFFWRLSKLGRIGSNKLRFDDDFVDRLNYQFTGLLLFMFIGLIGIRQYVGKPIQCWIPQEFTRGWEEYT 110
BLAST of Innexin vs. TrEMBL
Match: A0A1I8I373 (Innexin OS=Macrostomum lignano OX=282301 GN=inx PE=3 SV=1) HSP 1 Score: 90.5077 bits (223), Expect = 2.007e-18 Identity = 42/72 (58.33%), Postives = 58/72 (80.56%), Query Frame = 3 Query: 171 DVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEY 386 ++D TF ++L +L ++ K+RFDDD DRLNY+++ ++L + IGL+ IRQ VGKPIQCWIPQEFT+GWEEY Sbjct: 1402 EMDATFMWKLSKLGRIGSSKLRFDDDFADRLNYQFTGVILFLFIGLIGIRQYVGKPIQCWIPQEFTRGWEEY 1473 HSP 2 Score: 56.9954 bits (136), Expect = 1.074e-6 Identity = 24/47 (51.06%), Postives = 39/47 (82.98%), Query Frame = 3 Query: 246 DAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEY 386 D +D+LNY+++ L++M I ++ +RQ VGKPIQCW+PQEF++ WE++ Sbjct: 913 DFIDQLNYQFTGGLMIMFIAVIGLRQYVGKPIQCWVPQEFSKAWEDF 959
BLAST of Innexin vs. TrEMBL
Match: A0A4S2LXD4 (Innexin OS=Opisthorchis felineus OX=147828 GN=inx PE=3 SV=1) HSP 1 Score: 88.9669 bits (219), Expect = 7.131e-18 Identity = 46/83 (55.42%), Postives = 61/83 (73.49%), Query Frame = 3 Query: 144 SFSGF--GIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEY 386 SF G G +D TF ++L +L ++ ++RFDDD DRLNY+Y+ +L+ + IGL+ IRQ VGKPIQCWIPQEFT+GWEEY Sbjct: 62 SFGGHDHGAATAMDATFVWKLSKLGRIGSSRLRFDDDFADRLNYQYTGVLMFLFIGLIGIRQYVGKPIQCWIPQEFTRGWEEY 144
BLAST of Innexin vs. TrEMBL
Match: A0A183AGS5 (Innexin OS=Echinostoma caproni OX=27848 GN=inx PE=3 SV=1) HSP 1 Score: 87.8113 bits (216), Expect = 7.245e-18 Identity = 52/112 (46.43%), Postives = 72/112 (64.29%), Query Frame = 3 Query: 54 NLTSIFSVS*LFMSRGQFRDLVLTGDRRRSSFSGFGIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 N TS+F LF S+ + RD G + R + P +D F + L +L ++ +++FDDD DRLNY+Y+ +LL + IGL+ +RQ VGKPIQCWIPQEFT+GWEEY Sbjct: 9 NFTSLFHPDHLFSSQIKTRD----GLKIRIVREQWLYVPRMDAAFIWNLSKLGRIGSRRLQFDDDFADRLNYQYTGVLLFLFIGLIGVRQYVGKPIQCWIPQEFTRGWEEYA 116
BLAST of Innexin vs. TrEMBL
Match: A0A074ZHH4 (Innexin OS=Opisthorchis viverrini OX=6198 GN=inx PE=3 SV=1) HSP 1 Score: 88.5817 bits (218), Expect = 9.321e-18 Identity = 42/71 (59.15%), Postives = 57/71 (80.28%), Query Frame = 3 Query: 174 VDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEY 386 +D TF ++L +L ++ ++RFDDD DRLNY+Y+ +L+ + IGL+ IRQ VGKPIQCWIPQEFT+GWEEY Sbjct: 1 MDATFVWKLSKLGRIGSSRLRFDDDFADRLNYQYTGVLMFLFIGLIGIRQYVGKPIQCWIPQEFTRGWEEY 71
BLAST of Innexin vs. Planmine SMEST
Match: SMESG000001158.1 (SMESG000001158.1) HSP 1 Score: 181.03 bits (458), Expect = 6.361e-56 Identity = 100/100 (100.00%), Postives = 100/100 (100.00%), Query Frame = 3 Query: 90 MSRGQFRDLVLTGDRRRSSFSGFGIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 MSRGQFRDLVLTGDRRRSSFSGFGIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYSSLLLLMSIGLLTIRQNVGKPIQCWIPQEFTQGWEEYT Sbjct: 1 MSRGQFRDLVLTGDRRRSSFSGFGIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYSSLLLLMSIGLLTIRQNVGKPIQCWIPQEFTQGWEEYT 100
BLAST of Innexin vs. Planmine SMEST
Match: SMESG000060499.1 (SMESG000060499.1) HSP 1 Score: 102.449 bits (254), Expect = 2.015e-26 Identity = 62/110 (56.36%), Postives = 78/110 (70.91%), Query Frame = 3 Query: 90 MSRGQFRDLVLTGDRRRSSFSGF----------GIFPDVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 MSRGQ RD++ G+ RR SFS D+D TFF++L +L ++ +K+RFDDD VDRLNY+++ LLL M IGL+ IRQ VGKPIQCWIPQEFT+GWEEYT Sbjct: 1 MSRGQIRDILSAGEVRRPSFSHIVQSGSPVPGGDCGGDMDGTFFWRLSKLGRIGSNKLRFDDDFVDRLNYQFTGLLLFMFIGLIGIRQYVGKPIQCWIPQEFTRGWEEYT 110
BLAST of Innexin vs. Planmine SMEST
Match: SMESG000045304.1 (SMESG000045304.1) HSP 1 Score: 90.1225 bits (222), Expect = 5.256e-22 Identity = 41/71 (57.75%), Postives = 61/71 (85.92%), Query Frame = 3 Query: 174 VDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEY 386 +D TF ++LG+L ++ +++R+DDD VDRLNY+++ ++L + IGL++IRQ +GKPIQCWIPQEFT+GWEEY Sbjct: 1 MDATFVWKLGKLGRLGSNRLRYDDDFVDRLNYQFTGVILFLFIGLVSIRQYIGKPIQCWIPQEFTRGWEEY 71
BLAST of Innexin vs. Planmine SMEST
Match: SMESG000059204.1 (SMESG000059204.1) HSP 1 Score: 81.2629 bits (199), Expect = 7.008e-19 Identity = 39/71 (54.93%), Postives = 55/71 (77.46%), Query Frame = 3 Query: 174 VDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEY 386 +D TF ++L +L ++ +R+DDD +DRLNY+ + +LL + IG++ IRQ VGKPIQCW PQEFT+GWEEY Sbjct: 1 MDATFVWKLAKLGRLGSSHLRYDDDFIDRLNYQVTGILLFLFIGIIGIRQYVGKPIQCWSPQEFTRGWEEY 71
BLAST of Innexin vs. Planmine SMEST
Match: SMESG000048827.1 (SMESG000048827.1) HSP 1 Score: 76.6406 bits (187), Expect = 3.055e-17 Identity = 41/73 (56.16%), Postives = 51/73 (69.86%), Query Frame = 3 Query: 171 DVDNTFFFQLGRLSQVSEDKIRFDDDAVDRLNYKYXXXXXXXXXXXXTIRQNVGKPIQCWIPQEFTQGWEEYT 389 D+D F + +L + +R DDD DRLNYK SSLL+ I L+ +RQ VGKPIQCWIPQEFT+GWEEY+ Sbjct: 34 DLDCNFLWNFNKLGRWGSRHLRSDDDMADRLNYKVSSLLMFGFISLIGLRQYVGKPIQCWIPQEFTRGWEEYS 106 The following BLAST results are available for this feature:
BLAST of Innexin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Innexin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Innexin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Innexin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Innexin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Innexin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Innexin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Innexin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Innexin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Innexin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Innexin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Innexin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Innexin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Innexin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003995 ID=SMED30003995|Name=Innexin|organism=Schmidtea mediterranea sexual|type=transcript|length=391bpback to top protein sequence of SMED30003995-orf-1 >SMED30003995-orf-1 ID=SMED30003995-orf-1|Name=SMED30003995-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=100bp MSRGQFRDLVLTGDRRRSSFSGFGIFPDVDNTFFFQLGRLSQVSEDKIRFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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