Insulin-degrading enzyme
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003949 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: IDE (insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]) HSP 1 Score: 401.364 bits (1030), Expect = 2.102e-120 Identity = 218/593 (36.76%), Postives = 330/593 (55.65%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSIE-----------SNANG-PNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E I ++ IK W+N LN LP +N++IPT+F I ++ + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM + S A P I+++ FK LPL PL+K
Sbjct: 417 LNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: IDE (insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]) HSP 1 Score: 385.956 bits (990), Expect = 9.049e-115 Identity = 212/593 (35.75%), Postives = 324/593 (54.64%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSIE-----------SNANG-PNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E I ++ IK W+N LN LP +N++IPT+F I ++ + YP L++D +S+ WF QD + LPK+ ++ F + DP M ++ + L D + E Y A L+ L + I + + + ++ GYN+K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM + S A P I+++ FK LPL PL+K
Sbjct: 417 LNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: IDE (insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]) HSP 1 Score: 301.212 bits (770), Expect = 4.343e-90 Identity = 167/454 (36.78%), Postives = 248/454 (54.63%), Query Frame = 1
Query: 2467 LSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSIE-----------SNANG-PNATTIEDIVRFKTSLPLSPLIK 3789
+S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM + S A P I+++ FK LPL PL+K
Sbjct: 1 MSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 454
BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: NRDC (nardilysin convertase [Source:HGNC Symbol;Acc:HGNC:7995]) HSP 1 Score: 221.476 bits (563), Expect = 3.766e-58 Identity = 165/598 (27.59%), Postives = 291/598 (48.66%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAW-ENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTIND-ITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSE-LDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGP----NATTIEDIVRFKTSLPLSPLIKSVLPPV 3807
+K+++ F ++E +D V + +M +Y + IL G ++ E++P++I +N LVP + + ++ E KC +E W+GT+Y +E+I + + W N +LN DL LPAEN+YI TDFT+K+ + YP + + W+ +D + +PK++I + L + V+ + V++ T ++ E Y A +A LE+ + HGL I G+N K+ + II L F F ++ E + N KP A+ + ++ W+ D + D ++LE+ S+ K F SQ EGL+ GN S E++ + V +PL + + + LP + +N S + Y Q +S R +++L M EP F+ LRT + LGY V + + ++ + G + + Q+ K SE +D ++ EFL SF I ++EE F VTAL + + + ++ W E+ Y F R E+ L +K+D++N++ P SK+ LSV+V +G E +G ++ + ++++ T LP SPL+ + P+
Sbjct: 482 RKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILI-KPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYV----VDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKM---LSVHVVG---YGKYELEEDGTPSSEDSNSSCEVMQL-TYLPTSPLLADCIIPI 1067
BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: NRDC (nardilysin convertase [Source:HGNC Symbol;Acc:HGNC:7995]) HSP 1 Score: 221.09 bits (562), Expect = 6.522e-58 Identity = 165/598 (27.59%), Postives = 291/598 (48.66%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAW-ENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTIND-ITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSE-LDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGP----NATTIEDIVRFKTSLPLSPLIKSVLPPV 3807
+K+++ F ++E +D V + +M +Y + IL G ++ E++P++I +N LVP + + ++ E KC +E W+GT+Y +E+I + + W N +LN DL LPAEN+YI TDFT+K+ + YP + + W+ +D + +PK++I + L + V+ + V++ T ++ E Y A +A LE+ + HGL I G+N K+ + II L F F ++ E + N KP A+ + ++ W+ D + D ++LE+ S+ K F SQ EGL+ GN S E++ + V +PL + + + LP + +N S + Y Q +S R +++L M EP F+ LRT + LGY V + + ++ + G + + Q+ K SE +D ++ EFL SF I ++EE F VTAL + + + ++ W E+ Y F R E+ L +K+D++N++ P SK+ LSV+V +G E +G ++ + ++++ T LP SPL+ + P+
Sbjct: 546 RKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNI-LIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYV----VDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKM---LSVHVVG---YGKYELEEDGTPSSEDSNSSCEVMQL-TYLPTSPLLADCIIPI 1131
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776951:-1 gene:WBGene00018426.1 transcript:F44E7.4b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4) HSP 1 Score: 277.715 bits (709), Expect = 4.706e-77 Identity = 163/558 (29.21%), Postives = 295/558 (52.87%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVD-EEMWYGTKYVVENISEDYIKAWENI--KLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSAL-ITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIE 3705
+L ++FRF++ + ++ + EHIL Y++T++ P+ IK +++ L P M+V V++ F+ + + E YGT+ V +IS + +K +EN + L LP +N+YI T+F K + +P L+ D+G SR WF QD Y +PK + + + ++P ++++ + + +D++ E+ YNA LA L+ + + G+++ GY+EK ++F + ++ F D +F+++ E+ R + N +P + LI + +W+ E LL+ + +TLE+ + K FH E ++GN EA+ L ++ + + S RPL +++ RE+ L YV+ ++ + +TY G+ Q+T ++ ++ L +Q++ EP FN LRT E LGYIV +++ + +Q K + R+ FL S R I +M +EEF V+ + ++ EKPK + +F ++W EI C YNF R E+EV+ L + K D++ +DK I D+ +KL+V+V HG E
Sbjct: 438 ELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGV-QNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLELFDKKIRKDAAERRKLAVFV-----HGKNE 989
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772832:5777034:-1 gene:WBGene00018426.1 transcript:F44E7.4b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4) HSP 1 Score: 277.715 bits (709), Expect = 4.706e-77 Identity = 163/558 (29.21%), Postives = 295/558 (52.87%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVD-EEMWYGTKYVVENISEDYIKAWENI--KLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSAL-ITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIE 3705
+L ++FRF++ + ++ + EHIL Y++T++ P+ IK +++ L P M+V V++ F+ + + E YGT+ V +IS + +K +EN + L LP +N+YI T+F K + +P L+ D+G SR WF QD Y +PK + + + ++P ++++ + + +D++ E+ YNA LA L+ + + G+++ GY+EK ++F + ++ F D +F+++ E+ R + N +P + LI + +W+ E LL+ + +TLE+ + K FH E ++GN EA+ L ++ + + S RPL +++ RE+ L YV+ ++ + +TY G+ Q+T ++ ++ L +Q++ EP FN LRT E LGYIV +++ + +Q K + R+ FL S R I +M +EEF V+ + ++ EKPK + +F ++W EI C YNF R E+EV+ L + K D++ +DK I D+ +KL+V+V HG E
Sbjct: 438 ELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGV-QNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLELFDKKIRKDAAERRKLAVFV-----HGKNE 989
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776953:-1 gene:WBGene00018426.1 transcript:F44E7.4c.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4) HSP 1 Score: 267.314 bits (682), Expect = 7.163e-74 Identity = 164/574 (28.57%), Postives = 294/574 (51.22%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVD-EEMWYGTKYVVENISEDYIKAWENI--KLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHG----------------LKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSAL-ITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIE 3705
+L ++FRF++ + ++ + EHIL Y++T++ P+ IK +++ L P M+V V++ F+ + + E YGT+ V +IS + +K +EN + L LP +N+YI T+F K + +P L+ D+G SR WF QD Y +PK + + + ++P ++++ + + +D++ E+ YNA LA L+ + + G L + GY+EK ++F + ++ F D +F+++ E+ R + N +P + LI + +W+ E LL+ + +TLE+ + K FH E ++GN EA+ L ++ + + S RPL +++ RE+ L YV+ ++ + +TY G+ Q+T ++ ++ L +Q++ EP FN LRT E LGYIV +++ + +Q K + R+ FL S R I +M +EEF V+ + ++ EKPK + +F ++W EI C YNF R E+EV+ L + K D++ +DK I D+ +KL+V+V HG E
Sbjct: 379 ELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGV-QNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLELFDKKIRKDAAERRKLAVFV-----HGKNE 946
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776655:-1 gene:WBGene00018426.1 transcript:F44E7.4c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4) HSP 1 Score: 267.314 bits (682), Expect = 7.163e-74 Identity = 164/574 (28.57%), Postives = 294/574 (51.22%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVD-EEMWYGTKYVVENISEDYIKAWENI--KLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHG----------------LKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSAL-ITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIE 3705
+L ++FRF++ + ++ + EHIL Y++T++ P+ IK +++ L P M+V V++ F+ + + E YGT+ V +IS + +K +EN + L LP +N+YI T+F K + +P L+ D+G SR WF QD Y +PK + + + ++P ++++ + + +D++ E+ YNA LA L+ + + G L + GY+EK ++F + ++ F D +F+++ E+ R + N +P + LI + +W+ E LL+ + +TLE+ + K FH E ++GN EA+ L ++ + + S RPL +++ RE+ L YV+ ++ + +TY G+ Q+T ++ ++ L +Q++ EP FN LRT E LGYIV +++ + +Q K + R+ FL S R I +M +EEF V+ + ++ EKPK + +F ++W EI C YNF R E+EV+ L + K D++ +DK I D+ +KL+V+V HG E
Sbjct: 379 ELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGV-QNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLELFDKKIRKDAAERRKLAVFV-----HGKNE 946
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776951:-1 gene:WBGene00018426.1 transcript:F44E7.4a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4) HSP 1 Score: 267.314 bits (682), Expect = 1.277e-73 Identity = 164/574 (28.57%), Postives = 294/574 (51.22%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVD-EEMWYGTKYVVENISEDYIKAWENI--KLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHG----------------LKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSAL-ITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIE 3705
+L ++FRF++ + ++ + EHIL Y++T++ P+ IK +++ L P M+V V++ F+ + + E YGT+ V +IS + +K +EN + L LP +N+YI T+F K + +P L+ D+G SR WF QD Y +PK + + + ++P ++++ + + +D++ E+ YNA LA L+ + + G L + GY+EK ++F + ++ F D +F+++ E+ R + N +P + LI + +W+ E LL+ + +TLE+ + K FH E ++GN EA+ L ++ + + S RPL +++ RE+ L YV+ ++ + +TY G+ Q+T ++ ++ L +Q++ EP FN LRT E LGYIV +++ + +Q K + R+ FL S R I +M +EEF V+ + ++ EKPK + +F ++W EI C YNF R E+EV+ L + K D++ +DK I D+ +KL+V+V HG E
Sbjct: 438 ELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGV-QNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLELFDKKIRKDAAERRKLAVFV-----HGKNE 1005
BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: Ide (gene:FBgn0001247 transcript:FBtr0273273) HSP 1 Score: 367.466 bits (942), Expect = 9.165e-109 Identity = 206/602 (34.22%), Postives = 335/602 (55.65%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVR-PLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIE------DIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
KL EMRFRF+E + LV+ M I+ E +L PY+ E+RPDLIK +++ LVP++ ++ V+++FE C E +Y TKY + +++D +++WEN +LN++L L N +IPT+F I D +P ++ D + R W QD + PK+ ++ SN +A DP +N M+V L D +NE +Y+A LA+L+ + S G+ T G+++K V + ++ L F D K+F+++KE R ++NF +E+P + L+ L+ E W + +LL + +T + ++ K FF + HTE I+GN +A + V T + P+L Q+ RE L +Y+F N +S YLQ Q+ ++++ L +Q++ EP ++ LRT EQLGYIV ++ N G RI +QS K PS ++ R+ FL ++ +I M +EF+++ AL K LEKPK + +QF++++GEI Y+F+REE EV+ L K++K D ++Y+ KFI D + + LSV++ S+ T + S A T +E DIV FK+ L P+ L K +KL
Sbjct: 389 KLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPIALPFLDIKAKGARSKL 990
BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: Nrd1 (gene:FBgn0030344 transcript:FBtr0073601) HSP 1 Score: 156.762 bits (395), Expect = 3.152e-38 Identity = 140/568 (24.65%), Postives = 257/568 (45.25%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAK---NFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIK--SNGE-DISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFEL---VKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALIT-YLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDM---RVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIE 3705
Q+ +E FRF V ++ ++ + + IL G + E+ + +K +I+ L + + ++ + S E W+GT+Y + E + K WE+ +LFLP N+Y+ DFT+ S G ++ P+LL WF QD + LP++ ++ F + + ++ M + ++ V E++Y A A L + ++ + GL + GYNEK+ + V I ++ + L VK R K L + +L C++ + W + ++ + LE+ + F + + + LI GN+ A ++MN + + K R R +T + LP ++ + + N Q T+ +IT + Q + R + I+ L + EPLF+QLRT EQLGY VG +++++ + G+ I + S + + D R+ F I+ + ++E++ +L L + + ++ W EI Y F R +++ L L K +IIN+ I D ++KLSV V G E
Sbjct: 471 QRNEETGFRFHAQRPAFDNVQELVLNLKYFPPKDILTGKELYYEYNEEHLKELISHLNEMKFNLMVTSRRKYDDISAYDKTEEWFGTEYATIPMPEKWRKLWEDSVPLPELFLPESNKYVTDDFTLHWHSMGRPEVPDSPKLLIKTDTCELWFRQDDKFDLPEAHMAFYFISPMQRQNAKNDAMCSLYEEMVRFHVCEELYPAISAGLSYSLSTIEKGLLLKVCGYNEKLHLIVEAIAEGMLNVAETLDENMLSAFVKNQRKAFFNALIKPKALNRDIRL--CVLERIRWLMINKYKCLSSVILEDMREFAHQFPKELYIQSLIQGNYTEESAHNVMNSLLSRLNCKQIRERGRFLEDIT----VKLPVGTSIIRCHALNVQDTNTVITNFYQIGPNTVRVESILDLLMMFVDEPLFDQLRTKEQLGYHVGATVRLNYGIAGYSIMVNSQETKTTADYVEGRIEVFRAKMLQILRHLPQDEYEHTRDSLIKLKLVADLALSTEMSRNWDEIINESYLFDRRRRQIEVLRTLQKDEIINF---VISIDGDNMRKLSVQVIGHRPAGMPE 1029
BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: CG10588 (gene:FBgn0037037 transcript:FBtr0078284) HSP 1 Score: 146.362 bits (368), Expect = 5.016e-35 Identity = 154/590 (26.10%), Postives = 261/590 (44.24%), Query Frame = 1
Query: 2041 SQKLKEMRFRFRENSDLQILVSQISHDMGIYEA------EHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAK-NFESKCVDE-EMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTI---KSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVN----EQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALIT-YLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELD---MRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIEDIV 3750
SQ+++ FRF QI I H I E+ + +L GP + ++ I+ + + + + +E D+ E W+GT++ ++ + WE +L P N ++ TDF I +S +S P+ L N L WF QD ++ LP +I++ F L VR+ +V +M+ LFT V EQ+Y A A L + + GL + GYNEK+ + V I+ + T D + K+ + R I N + LS L ++ +++DIT+++ S+ + F + + +GLI GNF ++A LM V +T S+ L + L + +P S Y+ N+ ++ +IT Y Q + + I+ L I+ EP FNQLRT EQLGY +G ++ + I + + + D R+ F ++ +MS+ EF+ L + + + + W EI Y F R E ++ L LTK D++N+ + D L+KLSV V S S A + ++ D++
Sbjct: 428 SQQIENNNFRF------QIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYEESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIKELHYPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRNDLCELWFRQDNIFKLPDGYINLYFITPL-VRE---SVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDLKKRQIYNALINGKSLNLDLRLSIL-ENKRFSMISKYESVDDITMDDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHL-----LQIPLGSYYLRAKTLNEDDSNTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLND---NDKNNLRKLSVQVVGNHNQTS-NSTAQASRSGSLSDLL 997
BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: CG10588 (gene:FBgn0037037 transcript:FBtr0346528) HSP 1 Score: 146.362 bits (368), Expect = 5.016e-35 Identity = 154/590 (26.10%), Postives = 261/590 (44.24%), Query Frame = 1
Query: 2041 SQKLKEMRFRFRENSDLQILVSQISHDMGIYEA------EHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAK-NFESKCVDE-EMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTI---KSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVN----EQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV-ETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALIT-YLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELD---MRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIEDIV 3750
SQ+++ FRF QI I H I E+ + +L GP + ++ I+ + + + + +E D+ E W+GT++ ++ + WE +L P N ++ TDF I +S +S P+ L N L WF QD ++ LP +I++ F L VR+ +V +M+ LFT V EQ+Y A A L + + GL + GYNEK+ + V I+ + T D + K+ + R I N + LS L ++ +++DIT+++ S+ + F + + +GLI GNF ++A LM V +T S+ L + L + +P S Y+ N+ ++ +IT Y Q + + I+ L I+ EP FNQLRT EQLGY +G ++ + I + + + D R+ F ++ +MS+ EF+ L + + + + W EI Y F R E ++ L LTK D++N+ + D L+KLSV V S S A + ++ D++
Sbjct: 428 SQQIENNNFRF------QIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYEESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIKELHYPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRNDLCELWFRQDNIFKLPDGYINLYFITPL-VRE---SVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDLKKRQIYNALINGKSLNLDLRLSIL-ENKRFSMISKYESVDDITMDDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHL-----LQIPLGSYYLRAKTLNEDDSNTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLND---NDKNNLRKLSVQVVGNHNQTS-NSTAQASRSGSLSDLL 997
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: ide (insulin-degrading enzyme [Source:ZFIN;Acc:ZDB-GENE-070410-85]) HSP 1 Score: 390.963 bits (1003), Expect = 4.945e-117 Identity = 211/595 (35.46%), Postives = 330/595 (55.46%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHG------------SIESNANGPNATTIEDIVRFKTSLPLSPLIK 3789
+ L + FRF++ + S+++ + Y E IL Y++ EFRPDLI+ +++ L P ++V V+K+FE + E WYGT+Y E I+++ IK W+N LN LP +N++IPT+F I +D S P L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + II K+ TF D K+F+++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M +E ++ +PLL SQL RE+ +P+ YV+ N + Y Q Q+T +++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + +M +E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L LTK I+ +Y + D+ K+SV+V S EM ++ + P + ++D+ FK SLPL PL K
Sbjct: 394 KDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHILLKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELRDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRSLPLFPLTK 988
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1a (nardilysin a (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-070912-417]) HSP 1 Score: 201.06 bits (510), Expect = 5.767e-52 Identity = 148/558 (26.52%), Postives = 272/558 (48.75%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAW-ENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKL---LSCLIAE-VMW-THEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV--ETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSEL-DMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS 3681
QK++ F ++E +D V I +M ++ E L G +M EF+P++I +N L P + + ++ E +C E W+GT+Y E+I + + + W ++ LN L LPAEN++I TDF +K++ + YP + +N W+ +D + +PK+++ + + + P V+ + V++ ++ E Y A +A LE+ + HGL I G+N K+ + N I+ L F F + E + N L + EKL + LI E W T + + ++ ++++ + F S+ + EGL+ GN S E++ + V + F K P+L R + LP+ + +N S + Y Q ++ R +++L M EP F+ LRT E LGY V + + ++ + G + + Q+ K +EL + ++ EFL+SF + +S++ F+ VTAL + + + ++ W E+ Y F R +E+ L +TK +++N+ F+ + +KLSV+V
Sbjct: 481 QKIEANEFHYQEQTDPIEYVEDICENMQLFPKEDFLTGDQLMFEFKPEVISAALNLLTPEKANLLLLSPEHEGQCPLREKWFGTQYSTEDIEQHWREIWAKDFDLNPSLHLPAENKFIATDFALKTSDCPDTEYPVRIMNNDRGCLWYKKDNKFKIPKAYVRFHLISPVVQKSPKNLVLFDLFVNILVHNLAEPAYEADVAQLEYKLVAGEHGLVIKVKGFNHKLPLLFNLIVDYLADFSAAPDVFSMFAEQLKKTYFNI-----LIKPEKLGKDVRLLILEHSRWSTIQKYQAVLDGLSVDELMEFVSGFKSELYAEGLLQGNVTSTESMGFLQYVTEKLQFKKLSVEVPVL------FRVVELPQKHHLCKVKSLNKGDANSEVTVYYQSGPKNLREHTLMELLVMHMEEPCFDFLRTKETLGYHVYPTCRNTSGVLGFSVTVETQATKFNTELVETKIEEFLVSFGEKMNSLSDDAFRTQVTALVKLKGCEDTHLGEEVDRNWTEVVTQQYVFDRLSREIDALKLMTKAELVNW---FMEHRGEGNRKLSVHVVG 1024
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1a (nardilysin a (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-070912-417]) HSP 1 Score: 201.06 bits (510), Expect = 5.767e-52 Identity = 148/558 (26.52%), Postives = 272/558 (48.75%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAW-ENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKL---LSCLIAE-VMW-THEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV--ETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSEL-DMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS 3681
QK++ F ++E +D V I +M ++ E L G +M EF+P++I +N L P + + ++ E +C E W+GT+Y E+I + + + W ++ LN L LPAEN++I TDF +K++ + YP + +N W+ +D + +PK+++ + + + P V+ + V++ ++ E Y A +A LE+ + HGL I G+N K+ + N I+ L F F + E + N L + EKL + LI E W T + + ++ ++++ + F S+ + EGL+ GN S E++ + V + F K P+L R + LP+ + +N S + Y Q ++ R +++L M EP F+ LRT E LGY V + + ++ + G + + Q+ K +EL + ++ EFL+SF + +S++ F+ VTAL + + + ++ W E+ Y F R +E+ L +TK +++N+ F+ + +KLSV+V
Sbjct: 481 QKIEANEFHYQEQTDPIEYVEDICENMQLFPKEDFLTGDQLMFEFKPEVISAALNLLTPEKANLLLLSPEHEGQCPLREKWFGTQYSTEDIEQHWREIWAKDFDLNPSLHLPAENKFIATDFALKTSDCPDTEYPVRIMNNDRGCLWYKKDNKFKIPKAYVRFHLISPVVQKSPKNLVLFDLFVNILVHNLAEPAYEADVAQLEYKLVAGEHGLVIKVKGFNHKLPLLFNLIVDYLADFSAAPDVFSMFAEQLKKTYFNI-----LIKPEKLGKDVRLLILEHSRWSTIQKYQAVLDGLSVDELMEFVSGFKSELYAEGLLQGNVTSTESMGFLQYVTEKLQFKKLSVEVPVL------FRVVELPQKHHLCKVKSLNKGDANSEVTVYYQSGPKNLREHTLMELLVMHMEEPCFDFLRTKETLGYHVYPTCRNTSGVLGFSVTVETQATKFNTELVETKIEEFLVSFGEKMNSLSDDAFRTQVTALVKLKGCEDTHLGEEVDRNWTEVVTQQYVFDRLSREIDALKLMTKAELVNW---FMEHRGEGNRKLSVHVVG 1024
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422]) HSP 1 Score: 186.422 bits (472), Expect = 2.315e-47 Identity = 152/621 (24.48%), Postives = 289/621 (46.54%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWE-NIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKEN---RFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTH-----EDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDM---RVIEFLLSFRSIIMKMSEEEFQKYVTAL-KDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-----EMTHGSIESNANGPN--------------------ATTIEDIVRFKTSLPLSPLIK 3789
QK++ F ++E ++ V+ +S +M ++ EH L G +M +F P++I ++ L P + + ++ + C +E W+GT+Y VE+I +++ W + L+ +L LPAEN++I TDFT++++ + +P + DN R WF +D + +PK++ P V+ + V++ ++ E Y+A +A L++++ HGL I G+N K+ + + I+ L F F + E + II L + E+L + +++ H + + + D ++ + ++ F ++ EGL+ GNF S E+ + F + + P R + LP+ + +N S + Y Q ++ R +++L M EP F+ LRT E LGY V + ++ + G + +++ D ++ FL+SF ++++S+E F VTAL K K E + + + ++ W E+ Y F R KE+ L +TK +++++Y + +S +KLS++V + HG + ++N +T I DI F +SL L P K
Sbjct: 450 QKIEANEFHYQEQTEPIEFVANMSENMQLFPKEHFLCGDQLMFDFNPEVISAALSLLTPGKANILLLSPQHDGLCPLKEKWFGTQYSVEDIPQEFRDLWAGDFPLHPELQLPAENKFIATDFTLRTSDCPDTDFPVKIIDNERGRLWFRKDNKFKIPKAYARFQLLTPFIQESPKNLVLFDLFVNIVAHNLAELAYDAEVAQLQYNLLPGDHGLFIRLKGFNHKLPLLLKLIVDHLADFSATPDVFNMFIEQLKKTYYII--------LIRPERLGKDVRLQILEHHRWSVMQKYEAIMADPSVADLMTFANRFKAELFVEGLVQGNFTSAESKEFLQ----CFIEKLKYAPHPIEPPVLFRVVELPQTHHLCKVQSLNKADANSEVTVYYQTGLKNLREHTLMELLVMHMEEPCFDFLRTKETLGYQVYPICRNTSGILGFSVTVETQATKFSTDFVEGKIEAFLVSFGEKLVQLSDEAFGAQVTALIKLKECEDTQ-LGDEVDRNWFEVVTQQYVFDRLNKEIEILKDVTKDELVSFYMEHRKENS---RKLSIHVVGFGEEEKEIHGEDQCSSNPETSSYANISKLTFLSAAAMKEKSTMITDIRAFTSSLHLHPYHK 1054
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422]) HSP 1 Score: 186.422 bits (472), Expect = 2.315e-47 Identity = 152/621 (24.48%), Postives = 289/621 (46.54%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWE-NIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKEN---RFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTH-----EDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDM---RVIEFLLSFRSIIMKMSEEEFQKYVTAL-KDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-----EMTHGSIESNANGPN--------------------ATTIEDIVRFKTSLPLSPLIK 3789
QK++ F ++E ++ V+ +S +M ++ EH L G +M +F P++I ++ L P + + ++ + C +E W+GT+Y VE+I +++ W + L+ +L LPAEN++I TDFT++++ + +P + DN R WF +D + +PK++ P V+ + V++ ++ E Y+A +A L++++ HGL I G+N K+ + + I+ L F F + E + II L + E+L + +++ H + + + D ++ + ++ F ++ EGL+ GNF S E+ + F + + P R + LP+ + +N S + Y Q ++ R +++L M EP F+ LRT E LGY V + ++ + G + +++ D ++ FL+SF ++++S+E F VTAL K K E + + + ++ W E+ Y F R KE+ L +TK +++++Y + +S +KLS++V + HG + ++N +T I DI F +SL L P K
Sbjct: 450 QKIEANEFHYQEQTEPIEFVANMSENMQLFPKEHFLCGDQLMFDFNPEVISAALSLLTPGKANILLLSPQHDGLCPLKEKWFGTQYSVEDIPQEFRDLWAGDFPLHPELQLPAENKFIATDFTLRTSDCPDTDFPVKIIDNERGRLWFRKDNKFKIPKAYARFQLLTPFIQESPKNLVLFDLFVNIVAHNLAELAYDAEVAQLQYNLLPGDHGLFIRLKGFNHKLPLLLKLIVDHLADFSATPDVFNMFIEQLKKTYYII--------LIRPERLGKDVRLQILEHHRWSVMQKYEAIMADPSVADLMTFANRFKAELFVEGLVQGNFTSAESKEFLQ----CFIEKLKYAPHPIEPPVLFRVVELPQTHHLCKVQSLNKADANSEVTVYYQTGLKNLREHTLMELLVMHMEEPCFDFLRTKETLGYQVYPICRNTSGILGFSVTVETQATKFSTDFVEGKIEAFLVSFGEKLVQLSDEAFGAQVTALIKLKECEDTQ-LGDEVDRNWFEVVTQQYVFDRLNKEIEILKDVTKDELVSFYMEHRKENS---RKLSIHVVGFGEEEKEIHGEDQCSSNPETSSYANISKLTFLSAAAMKEKSTMITDIRAFTSSLHLHPYHK 1054
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154]) HSP 1 Score: 394.815 bits (1013), Expect = 1.991e-118 Identity = 219/607 (36.08%), Postives = 340/607 (56.01%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------ESNAN------GPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
L + FRF++ + S+++ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E+++++ I+ W+ LN LP +N++IPT+F I +D +SYP L++D +S+ WF QD + LPKS ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GY++K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN A+ +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST +++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + M++E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L K DI+N+Y + D+ K+SV+V S EM + +++ N P I ++ FK SLPL PL+K P + M TAKL
Sbjct: 387 LNAVAFRFKDKERPRGYTSKVAGLLHYYPLEEVLSAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEDLAQEVIEKWQKADLNGKFKLPMKNEFIPTNFEILPLEKDATSYPALIKDTAMSKLWFKQDDKFFLPKSCLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSLKGYSDKQHILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLLRLKAFIPQLLSRLHVEALVHGNITKQAAMGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMLLELLCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLKTTEKSLEDMADEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLVKEDIMNFYKNMLSVDAPRRHKVSVHVLSREMDSCPVVGEFPSQNDVNLAPAPALPQPEVISNMTEFKRSLPLFPLVK---PHINFM-TAKL 989
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154]) HSP 1 Score: 395.201 bits (1014), Expect = 2.429e-118 Identity = 219/607 (36.08%), Postives = 340/607 (56.01%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------ESNAN------GPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
L + FRF++ + S+++ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E+++++ I+ W+ LN LP +N++IPT+F I +D +SYP L++D +S+ WF QD + LPKS ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GY++K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN A+ +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST +++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + M++E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L K DI+N+Y + D+ K+SV+V S EM + +++ N P I ++ FK SLPL PL+K P + M TAKL
Sbjct: 401 LNAVAFRFKDKERPRGYTSKVAGLLHYYPLEEVLSAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEDLAQEVIEKWQKADLNGKFKLPMKNEFIPTNFEILPLEKDATSYPALIKDTAMSKLWFKQDDKFFLPKSCLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSLKGYSDKQHILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLLRLKAFIPQLLSRLHVEALVHGNITKQAAMGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMLLELLCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLKTTEKSLEDMADEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLVKEDIMNFYKNMLSVDAPRRHKVSVHVLSREMDSCPVVGEFPSQNDVNLAPAPALPQPEVISNMTEFKRSLPLFPLVK---PHINFM-TAKL 1003
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154]) HSP 1 Score: 395.201 bits (1014), Expect = 2.586e-118 Identity = 219/609 (35.96%), Postives = 341/609 (55.99%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------ESNAN------GPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
+ L + FRF++ + S+++ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E+++++ I+ W+ LN LP +N++IPT+F I +D +SYP L++D +S+ WF QD + LPKS ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GY++K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN A+ +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST +++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + M++E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L K DI+N+Y + D+ K+SV+V S EM + +++ N P I ++ FK SLPL PL+K P + M TAKL
Sbjct: 412 KDLNAVAFRFKDKERPRGYTSKVAGLLHYYPLEEVLSAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEDLAQEVIEKWQKADLNGKFKLPMKNEFIPTNFEILPLEKDATSYPALIKDTAMSKLWFKQDDKFFLPKSCLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSLKGYSDKQHILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLLRLKAFIPQLLSRLHVEALVHGNITKQAAMGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMLLELLCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLKTTEKSLEDMADEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLVKEDIMNFYKNMLSVDAPRRHKVSVHVLSREMDSCPVVGEFPSQNDVNLAPAPALPQPEVISNMTEFKRSLPLFPLVK---PHINFM-TAKL 1016
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154]) HSP 1 Score: 395.201 bits (1014), Expect = 2.820e-118 Identity = 219/607 (36.08%), Postives = 340/607 (56.01%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------ESNAN------GPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
L + FRF++ + S+++ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E+++++ I+ W+ LN LP +N++IPT+F I +D +SYP L++D +S+ WF QD + LPKS ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GY++K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN A+ +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST +++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + M++E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L K DI+N+Y + D+ K+SV+V S EM + +++ N P I ++ FK SLPL PL+K P + M TAKL
Sbjct: 409 LNAVAFRFKDKERPRGYTSKVAGLLHYYPLEEVLSAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEDLAQEVIEKWQKADLNGKFKLPMKNEFIPTNFEILPLEKDATSYPALIKDTAMSKLWFKQDDKFFLPKSCLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSLKGYSDKQHILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLLRLKAFIPQLLSRLHVEALVHGNITKQAAMGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMLLELLCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLKTTEKSLEDMADEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLVKEDIMNFYKNMLSVDAPRRHKVSVHVLSREMDSCPVVGEFPSQNDVNLAPAPALPQPEVISNMTEFKRSLPLFPLVK---PHINFM-TAKL 1011
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154]) HSP 1 Score: 394.815 bits (1013), Expect = 3.445e-118 Identity = 219/607 (36.08%), Postives = 340/607 (56.01%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------ESNAN------GPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
L + FRF++ + S+++ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E+++++ I+ W+ LN LP +N++IPT+F I +D +SYP L++D +S+ WF QD + LPKS ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GY++K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN A+ +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST +++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + M++E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L K DI+N+Y + D+ K+SV+V S EM + +++ N P I ++ FK SLPL PL+K P + M TAKL
Sbjct: 407 LNAVAFRFKDKERPRGYTSKVAGLLHYYPLEEVLSAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEDLAQEVIEKWQKADLNGKFKLPMKNEFIPTNFEILPLEKDATSYPALIKDTAMSKLWFKQDDKFFLPKSCLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSLKGYSDKQHILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLLRLKAFIPQLLSRLHVEALVHGNITKQAAMGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMLLELLCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLKTTEKSLEDMADEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLVKEDIMNFYKNMLSVDAPRRHKVSVHVLSREMDSCPVVGEFPSQNDVNLAPAPALPQPEVISNMTEFKRSLPLFPLVK---PHINFM-TAKL 1009
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Ide (insulin degrading enzyme [Source:MGI Symbol;Acc:MGI:96412]) HSP 1 Score: 399.823 bits (1026), Expect = 2.160e-120 Identity = 218/593 (36.76%), Postives = 327/593 (55.14%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTH----GSIESNAN--------GPNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y +L Y++ EFRPDLI +++ L P ++V V+K+FE K E WYGT+Y E I ED I+ W+N LN LP +N++IPT+F I S +D + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YN+ R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM G S + P I ++ FK LPL PL+K
Sbjct: 385 LNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 977
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Ide (insulin degrading enzyme [Source:MGI Symbol;Acc:MGI:96412]) HSP 1 Score: 399.823 bits (1026), Expect = 2.160e-120 Identity = 218/593 (36.76%), Postives = 327/593 (55.14%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTH----GSIESNAN--------GPNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y +L Y++ EFRPDLI +++ L P ++V V+K+FE K E WYGT+Y E I ED I+ W+N LN LP +N++IPT+F I S +D + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YN+ R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM G S + P I ++ FK LPL PL+K
Sbjct: 385 LNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 977
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Nrd1 (nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386]) HSP 1 Score: 212.616 bits (540), Expect = 1.635e-55 Identity = 160/595 (26.89%), Postives = 285/595 (47.90%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWE-NIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTIND-ITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSE-LDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNAN-GPNATTIEDIVRFKTSLPLSPLIKSVLPPV 3807
QK+++ F ++E +D V + +M +Y + L G ++ E++P++I +N LVP + + ++ E +C +E W+GT+Y +E+I + + W+ N LN DL LPAEN+YI TDFT+K+ + YP + + W+ +D + +PK++I + L + V+ + V++ T ++ E Y A +A LE+ + HGL I G+N K+ + II L F F ++ E + N KP A+ + ++ W+ D + D ++L++ ++ K F SQ EGL+ GN S E++ + V PL + + + LP + +N S + Y Q +S R +++L M EP F+ LRT + LGY V + + ++ + G + + Q+ K SE +D ++ EFL SF I ++E+ F VTAL + + + ++ W E+ Y F R E+ L +K+D+++++ P SK+ LSV+V + E A G ++ + E + T LP SP++ P+
Sbjct: 513 QKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILI-KPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYV----VDKLNFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKM---LSVHVVGYGKYELEEDGAPFGEDSNSREGMQL--TYLPPSPVLAESTTPI 1097
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Nrd1 (nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386]) HSP 1 Score: 212.616 bits (540), Expect = 1.815e-55 Identity = 160/595 (26.89%), Postives = 285/595 (47.90%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWE-NIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTIND-ITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSE-LDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNAN-GPNATTIEDIVRFKTSLPLSPLIKSVLPPV 3807
QK+++ F ++E +D V + +M +Y + L G ++ E++P++I +N LVP + + ++ E +C +E W+GT+Y +E+I + + W+ N LN DL LPAEN+YI TDFT+K+ + YP + + W+ +D + +PK++I + L + V+ + V++ T ++ E Y A +A LE+ + HGL I G+N K+ + II L F F ++ E + N KP A+ + ++ W+ D + D ++L++ ++ K F SQ EGL+ GN S E++ + V PL + + + LP + +N S + Y Q +S R +++L M EP F+ LRT + LGY V + + ++ + G + + Q+ K SE +D ++ EFL SF I ++E+ F VTAL + + + ++ W E+ Y F R E+ L +K+D+++++ P SK+ LSV+V + E A G ++ + E + T LP SP++ P+
Sbjct: 557 QKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILI-KPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYV----VDKLNFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKM---LSVHVVGYGKYELEEDGAPFGEDSNSREGMQL--TYLPPSPVLAESTTPI 1141
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Nrd1 (nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386]) HSP 1 Score: 212.231 bits (539), Expect = 3.229e-55 Identity = 160/595 (26.89%), Postives = 285/595 (47.90%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWE-NIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTIND-ITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSE-LDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNAN-GPNATTIEDIVRFKTSLPLSPLIKSVLPPV 3807
QK+++ F ++E +D V + +M +Y + L G ++ E++P++I +N LVP + + ++ E +C +E W+GT+Y +E+I + + W+ N LN DL LPAEN+YI TDFT+K+ + YP + + W+ +D + +PK++I + L + V+ + V++ T ++ E Y A +A LE+ + HGL I G+N K+ + II L F F ++ E + N KP A+ + ++ W+ D + D ++L++ ++ K F SQ EGL+ GN S E++ + V PL + + + LP + +N S + Y Q +S R +++L M EP F+ LRT + LGY V + + ++ + G + + Q+ K SE +D ++ EFL SF I ++E+ F VTAL + + + ++ W E+ Y F R E+ L +K+D+++++ P SK+ LSV+V + E A G ++ + E + T LP SP++ P+
Sbjct: 625 QKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILI-KPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYV----VDKLNFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKM---LSVHVVGYGKYELEEDGAPFGEDSNSREGMQL--TYLPPSPVLAESTTPI 1209
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|P14735|IDE_HUMAN (Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4) HSP 1 Score: 401.364 bits (1030), Expect = 1.010e-119 Identity = 218/593 (36.76%), Postives = 330/593 (55.65%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSIE-----------SNANG-PNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E I ++ IK W+N LN LP +N++IPT+F I ++ + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM + S A P I+++ FK LPL PL+K
Sbjct: 417 LNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|Q24K02|IDE_BOVIN (Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=IDE PE=2 SV=1) HSP 1 Score: 401.364 bits (1030), Expect = 1.062e-119 Identity = 219/593 (36.93%), Postives = 331/593 (55.82%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSIE-----------SNANG-PNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y E +L Y++ EFRPDLI+ +++ L P ++V V+K+FE K E WYGT+Y E I ++ IK W+N LN LP +N++IPT+F I S ++ + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + II K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM + S A P I+++ FK LPL PL+K
Sbjct: 417 LNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPMKNEFIPTNFEILSLEKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|P35559|IDE_RAT (Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1) HSP 1 Score: 398.282 bits (1022), Expect = 1.133e-118 Identity = 216/595 (36.30%), Postives = 328/595 (55.13%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTH----GSIESNAN--------GPNATTIEDIVRFKTSLPLSPLIK 3789
+ L + FRF++ + S+I+ + Y +L Y++ EFRPDLI +++ L P ++V V+K+FE K E WYGT+Y E I ED I+ W+N LN LP +N++IPT+F I + +D + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YN+ R+ EV+ L L+K DII +Y + + D+ K+SV+V + EM G S + P I ++ FK LPL PL+K
Sbjct: 415 KDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILALEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQRRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 1009
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|Q9JHR7|IDE_MOUSE (Insulin-degrading enzyme OS=Mus musculus OX=10090 GN=Ide PE=1 SV=1) HSP 1 Score: 396.741 bits (1018), Expect = 3.925e-118 Identity = 217/593 (36.59%), Postives = 326/593 (54.97%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTH----GSIESNAN--------GPNATTIEDIVRFKTSLPLSPLIK 3789
L + FRF++ + S+I+ + Y +L Y++ EFRPDLI +++ L P ++V V+K+FE K E WYGT+Y E I ED I+ W+N LN LP +N++IPT+F I S +D + YP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ YN+K + + I K+ TF D K+FE++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN AL +M VE ++ +PLL SQL RE+ LP+ +V+ N + Y Q QST ++ ++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL++ I M+EE FQK++ AL + L+KPK + + KYWGEI YN+ R+ EV+ L LTK DII +Y + + D+ K+SV+V + EM G S + P I ++ FK LPL PL+K
Sbjct: 417 LNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 1009
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|P22817|IDE_DROME (Insulin-degrading enzyme OS=Drosophila melanogaster OX=7227 GN=Ide PE=1 SV=4) HSP 1 Score: 367.466 bits (942), Expect = 9.187e-108 Identity = 206/602 (34.22%), Postives = 335/602 (55.65%), Query Frame = 1
Query: 2047 KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVR-PLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIE------DIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
KL EMRFRF+E + LV+ M I+ E +L PY+ E+RPDLIK +++ LVP++ ++ V+++FE C E +Y TKY + +++D +++WEN +LN++L L N +IPT+F I D +P ++ D + R W QD + PK+ ++ SN +A DP +N M+V L D +NE +Y+A LA+L+ + S G+ T G+++K V + ++ L F D K+F+++KE R ++NF +E+P + L+ L+ E W + +LL + +T + ++ K FF + HTE I+GN +A + V T + P+L Q+ RE L +Y+F N +S YLQ Q+ ++++ L +Q++ EP ++ LRT EQLGYIV ++ N G RI +QS K PS ++ R+ FL ++ +I M +EF+++ AL K LEKPK + +QF++++GEI Y+F+REE EV+ L K++K D ++Y+ KFI D + + LSV++ S+ T + S A T +E DIV FK+ L P+ L K +KL
Sbjct: 389 KLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPIALPFLDIKAKGARSKL 990
BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: T1ISN5 (Uncharacterized protein OS=Strigamia maritima OX=126957 PE=3 SV=1) HSP 1 Score: 429.483 bits (1103), Expect = 1.714e-127 Identity = 234/611 (38.30%), Postives = 356/611 (58.27%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIES--------NANG--------PNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPT-AKL 3831
L M FRF++ Q ++ + +Y + +L GPY+MTE++ DLI +I+N LVP +++V + K FE EE WY TK+ +++ISED + W N N +L LP+ N++IPT+F + E++S+ P LL+++ L+R WF QD +LLPK+ I+ F + L DP M +M+V LF D++ E Y A LA L +++ N +G+ ++ GYN+K V V I+ K F + K+F+++KE R ++NF +E+P A S L+AE WT E+LL + D+TL S+ S+ H EGLI+GN S +AL L + VE K + +PLL+SQL REI L S Y++ N+ +S ++ Y Q Q T ++VI++L Q++ EP FN LRT EQLGYIV ++ +N QG + +QS + P LD R+ FLL+ ++ I M +E+F K+ AL + LEKPK ++ Q +KYWGEI YNF R+ EV+ L +TK +++++Y+KFI +S KL+V + S G+ ES A+G A TI++I FK+S PL PL++ + PT AKL
Sbjct: 416 LNSMTFRFKDKERPQTYTCALAGLLHMYPVQEVLCGPYLMTEYKEDLIMHILNMLVPEKIRVSVIGKKFEESAEKEETWYKTKHDIKDISEDVLDKWCNAGFNSNLTLPSPNEFIPTNFELIKFDEEVSALPTLLKNSALTRLWFKQDNEFLLPKAVINFEFVSPLTYLDPLHCNMAYMLVQLFRDALTEYTYAADLAGLSYNLTNTKYGMILSVKGYNDKQHVLVEKIMEKFTNFEINPKRFDILKEAYIRGLKNFHAEQPHQHAIYYTSVLLAETAWTKEELLESAEDLTLIRMQSFVAELLSKCHIEGLIHGNVNSKKALELTDIVEKKLFKKMKTKPLLQSQLVRDREIQLSNGSYYIYKNENSVHRSSCVVVYYQTGLQDTESNVILELFCQVIAEPCFNVLRTQEQLGYIVFSGVRRANGAQGVLVLIQSDRSPQYLDRRIEAFLLAMKTHIHDMDDEQFIKHKEALIARRLEKPKKLVHQTSKYWGEITSQQYNFDRDNIEVASLKTVTKDNVMSFYEKFISTESSARHKLAVEIVSTAVGGAGESINNEQDMPPADGMVILPRNLTEAITIQNITEFKSSHPLFPLVRPYINIASSSPTKAKL 1026
BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A4E0RGZ5 (Insulin-degrading enzyme OS=Fasciola hepatica OX=6192 GN=D915_002296 PE=3 SV=1) HSP 1 Score: 424.861 bits (1091), Expect = 4.182e-126 Identity = 223/614 (36.32%), Postives = 358/614 (58.31%), Query Frame = 1
Query: 1999 NLVCTNQFH-FINFHSQKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGED-ISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFV-PDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHG-SIESNANGPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAK 3828
NL+C+++ +I +Q L +++FRF++ V ++ +M Y+ E L GPY++ F P L+K+I++CL P +V+ V+K F +C D E WYGT+++ NIS++ ++ W + ++ + LP N+YI TDFTI+ + I+ PELL N + R W QD +LLPK FI+I + LA + P T++ + V+LF D ++E YN LA + D + G+K++ GY K+ + ++I L+ F+ P +F ++E R I+NFD + P QA L+ ++ + WT+E+L + DIT + ++ FF+ E LIYGN + EAL +E F F +P+ +++T RE+++P+ S +F + QPTSA+ YLQ EQS +D ++ L +I+ E F LRT +QL YIV + SN++QG R+ LQS ++P +L+ + FL S I+ MS+EEF K+V +L +++EKPK M Q +++W EI C+HYNFKR E+ EL K+TK+D++ +YD I P S KKLSV+V S HG ++ + I+D +FK S LSP+ + +P K P+ +
Sbjct: 360 NLMCSHEPQEWIFRENQSLNDLQFRFKDKEPPYDYVIELGTNMLHYKLEDALTGPYLLDSFEPVLVKDILSCLHPENSRVFEVSKTFAPQCTDTERWYGTRFLCMNISDEDLQTWRDCGVDPHMVLPEPNKYIATDFTIEPPPDGPIAETPELLYANDIFRLWHIQDEEFLLPKGFITIHLISPLAFQSPLRTLLTALYVELFVDHISEDAYNCMLAGMNVDFKRTTQGVKLSLSGYTHKLGLLTRNVIDHLIHFLAPTPDRFRYLREEIGREIKNFDLKSPYQQAGIFLTNVLCDRSWTNEELATAFPDITYDVLLNFIPQFFASLSEETLIYGNVTTKEALDCQRMIEGAFMTQFNSKPIPPTEVTMAREVIIPKQSKLIFQRLTLSQPTSAICYYLQTEEQSVHSDTMLNLFCEIINELAFYTLRTEQQLSYIVHTGPRRSNTLQGLRVILQSSERPDDLESHIESFLSSLHDTILFMSDEEFDKHVASLTTRLMEKPKGMTEQNSRFWCEIACHHYNFKRYVLEMKELDKITKSDVLEFYDIHISPPSATRKKLSVHVISSQKHGCNMRVLSPVVKGDIIKDPKKFKDSCVLSPVAEPFIPLEPKFPSER 973
BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A419PX02 (Insulin-degrading enzyme (Fragment) OS=Clonorchis sinensis OX=79923 GN=IDE PE=4 SV=1) HSP 1 Score: 400.208 bits (1027), Expect = 9.312e-122 Identity = 205/560 (36.61%), Postives = 333/560 (59.46%), Query Frame = 1
Query: 2131 YEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSY-PELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTF-VPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHG-SIESNANGPNATTIEDIVRFKTSLPLSPLIKSVLP 3801
Y ++ +L GPY++ F P LIK+++ CL + +++ V+++++++C D E WY T Y+ +I E I+AW+N++ + D+ LP+ N+YI TDFTI +D S+ PELL + L+R W+ D+ + LPK+F++ + LA +P T++ + V+LF D + E+ YN LA + +I + G+K++F GY+ K+ + + ++I KL+ F P ++ ++E +R I NF + QA L+ +I + W +++L + +IT + + + F+SQ E L YGN +ALS + +E F F +PL +Q+T RE +LP + VF + QP SA+ YLQG +QSTR D ++ L +I+ E N L+T EQLG+IV + SN++QG R +QS +P EL+ + FL SFR I+ MS EEFQ +V +L ++LEKPK+M + ++W EI C+HYNFKR+ E L ++T T+I+ ++D +I P S KKLS++V S HG +++S + I D +FK LS L + LP
Sbjct: 2 YASQDVLRGPYLLRTFEPQLIKDVLGCLHASNSRLFLVSRSYQTQCTDIERWYNTHYLRVDIPEKTIQAWQNVECDFDMTLPSANKYIATDFTIYPRPKDFSTVAPELLINTDLARLWYYPDSSFGLPKAFVTFHIISPLAFFNPLKTLLTALYVELFEDHIGEEAYNCLLAGMVVEIRRTTQGIKLSFTGYSHKLGLLIRNVIDKLIHFFTPSVDRYRCMREEIWREIANFGMKSSYQQAGIYLTNVITDRSWINDELAANFPEITFDLLTGFIQEFYSQLFIEILAYGNITLEDALSHRDLIEGAFQMQFGTKPLGPTQITMARETILPGQTKAVFQRLTQHQPNSAICYYLQGPQQSTRKDTVLNLFCEIINEHAQNVLKTEEQLGHIVYTGARRSNTLQGFRCIIQSNMRPDELEKSIDNFLYSFRDTIVFMSAEEFQMHVDSLTSRLLEKPKNMAEKNARFWSEIACHHYNFKRQLLEAEILKEITLTEILEFFDYYISPSSNKRKKLSIHVVSVERHGCNLKSTFSAVRGDLIRDHNKFKDGCRLSDLAQPFLP 561
BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A1W7RAD0 (Insulin-degrading enzyme OS=Hadrurus spadix OX=141984 PE=3 SV=1) HSP 1 Score: 409.838 bits (1052), Expect = 2.376e-120 Identity = 224/614 (36.48%), Postives = 352/614 (57.33%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATT----------------IEDIVRFKTSLPLSPLIK---SVLPPVKKMPTAK 3828
Q L M FRF++ Q ++ + Y E +L G Y+M ++RPDLI++++N L P +++V + K FE C EE WYGTKY +E ISE + W + +++L LP +N++IPT+F + ++ ++ S+ P +++++ +SR WF QD + LPK+ +S F + LA DP M F+ V LF D++NE Y A LA L +++NN +G+ +T GYN+K V + I+ KL +F D K+FE++KE+ R ++NF +E+P A L+AE +W++++LL ++T+E S S+ H E LI+GN +AL+L++ VE+ + + RPLL SQL RE L E S+++ NN +SA+ TY Q Q T+ +V+++L QI+ E FN LRT EQLGYIV ++ ++ +QG + +QS K P+ +D R+ F + + +MS EEF+ + L + LEKPK +++ KYW EI YNF R+ EVS L L+K D+ +++ + I D+ KKLSV++TS + S NG + IE+I FK+SL L PL+K + P V AK
Sbjct: 410 QDLAAMTFRFKDRERPQTYTYSLAGMLHDYPMEEVLCGSYLMHDYRPDLIEDLLNRLTPDKIRVAIIGKKFEECCDCEEQWYGTKYKLEPISESVLSKWSSAGSHNNLCLPTKNEFIPTNFQLATHEQEYSNLPVMIKNSEMSRVWFKQDNEFNLPKAILSFEFESPLAYLDPHHCNMTFLFVQLFRDALNEYTYAAELAGLSYNLNNTKYGMLLTVKGYNDKQHVLLGKIMDKLTSFNIDPKRFEILKESYIRGLKNFQAEQPHQHAVYYTCLLLAERIWSNDELLDVAEELTVEKVQSVIPQLLSRMHVEALIHGNLTKQKALNLVSIVESKLEETMKWRPLLPSQLIRDREHQLKEGSHFLLEKTNNVHRSSAVETYYQCGLQETKCNVLVELFCQIITEHCFNILRTQEQLGYIVCSGVRRASGVQGVHVIVQSDKSPAYVDSRIEAFFVFIDKYLDEMSLEEFESHKLTLAARRLEKPKKLVQLSAKYWNEITSRQYNFDRDNIEVSCLHTLSKDDVCSFFKELIAGDATSRKKLSVHITSSVLEAQNNSCDNGESNVVIDGLSPVPRHIQPPIKIENITEFKSSLGLYPLVKPCIDIAPIVAGTSAAK 1023
BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A1W4X5N9 (insulin-degrading enzyme OS=Agrilus planipennis OX=224129 GN=LOC108741211 PE=3 SV=1) HSP 1 Score: 407.912 bits (1047), Expect = 9.558e-120 Identity = 221/606 (36.47%), Postives = 348/606 (57.43%), Query Frame = 1
Query: 2026 FINFHSQKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNA----NGPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
+I + + M FRF++ + +S + H + Y E +L Y +TE+RPD+I NI+N P ++++ +AK F+ + D E WYGT+Y +E I ++ + W N +++ LP +N +IPT+F I+ +DI+ +P +++D L+R WF QD +LLPK+ + F + LA DP M M+V LF D++NE Y A +A L+++++N +GL + GY++K + + I+ KL +F D K+FE+ KEN R ++NF +E+P A L+ L+ E WT E+LL++ + +T+E ++ S+ H E L++GN L L++ VET + F + PLL QL RE+ L + +Y++ NN S + Y Q Q+T N+V+++L QI+ P FN LRT EQLGYIV ++ SN +QG R+ +QS + P LD R+ FL S +M+MS EEF+++ AL + LEKPK + Q +W EI Y+F R EV+ L KLTK DIINYY + +K KK+SV+V S G+ SN+ + IED+ FK+S + PL++ + +K KL
Sbjct: 407 WIQEEQKDIAAMIFRFKDKESPRTYISGLVHHLQDYPIEDVLCIHYHLTEWRPDIINNILNSFTPDKVRIGVIAKKFQKEATDAEPWYGTQYKLEKIPQEVLNDWTNAGTSNEFRLPDKNDFIPTNFNIEPLDKDITEHPAIVQDTALTRVWFKQDDKFLLPKANLLFDFVSPLAYLDPMNCNMTHMLVQLFKDALNEYAYAAEIAGLKWELSNTKYGLILEVGGYSDKQHILLRKIMEKLTSFKIDPKRFEIFKENYIRQLKNFAAEQPYQHAVYYLAVLLTEHSWTKEELLASTDQLTIERLEAFIPQMLSKLHIECLLHGNLSKKRGLELVDIVETSLTSSFCMSPLLPRQLLLNRELKLDDGCSYLYEVQNNVHKLSCIELYFQCGLQNTENNVLLELFAQIIQVPCFNVLRTQEQLGYIVFSGVRRSNGVQGLRVIVQSDRHPEYLDTRIELFLESMLKHVMEMSNEEFERHKEALALQRLEKPKRLSVQSQIFWQEITSQQYHFDRANVEVAHLRKLTKDDIINYYQYLLDKAAKQRKKISVHVVSMADGGAGTSNSPKKEEKGSVEVIEDVTVFKSSHGMFPLVQPYICMERKGKKCKL 1012
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253]) HSP 1 Score: 397.512 bits (1020), Expect = 1.541e-119 Identity = 213/595 (35.80%), Postives = 334/595 (56.13%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------------ESNANGPNATTIEDIVRFKTSLPLSPLIK 3789
+ L + FRF++ + S+++ + Y E IL Y++ +FRPDLI+ +++ L P ++V V+K+FE + E WYGT+Y E+IS++ IK W+N LN LP +N++IPT+F I +D SYP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I+ K+ TF D K+F+++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN ALS+M VE ++ +PLL SQL RE+ +P+ YV+ N + Y Q Q+T ++++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + +MS+E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L+K +I+ +Y + D+ K+SV+V S EM + + P ++D+ FK SLPL PL K
Sbjct: 396 KDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYMLEDFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDKTEEWYGTQYKQESISDEVIKKWQNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSYPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSVKGYNDKQHILLKKIVEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALSMMQMVEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQTTHDNMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMSDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLSKDNIMQFYRDLLAIDAPKRHKVSVHVLSREMDSCPVVGEFPAQNDVNLAPAPSLPQPVLVQDMTEFKRSLPLFPLAK 990
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253]) HSP 1 Score: 397.127 bits (1019), Expect = 3.046e-119 Identity = 213/595 (35.80%), Postives = 334/595 (56.13%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------------ESNANGPNATTIEDIVRFKTSLPLSPLIK 3789
+ L + FRF++ + S+++ + Y E IL Y++ +FRPDLI+ +++ L P ++V V+K+FE + E WYGT+Y E+IS++ IK W+N LN LP +N++IPT+F I +D SYP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I+ K+ TF D K+F+++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN ALS+M VE ++ +PLL SQL RE+ +P+ YV+ N + Y Q Q+T ++++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + +MS+E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L+K +I+ +Y + D+ K+SV+V S EM + + P ++D+ FK SLPL PL K
Sbjct: 409 KDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYMLEDFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDKTEEWYGTQYKQESISDEVIKKWQNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSYPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSVKGYNDKQHILLKKIVEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALSMMQMVEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQTTHDNMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMSDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLSKDNIMQFYRDLLAIDAPKRHKVSVHVLSREMDSCPVVGEFPAQNDVNLAPAPSLPQPVLVQDMTEFKRSLPLFPLAK 1003
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253]) HSP 1 Score: 390.193 bits (1001), Expect = 5.657e-117 Identity = 208/566 (36.75%), Postives = 320/566 (56.54%), Query Frame = 1
Query: 2131 YEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------------ESNANGPNATTIEDIVRFKTSLPLSPLIK 3789
Y E IL Y++ +FRPDLI+ +++ L P ++V V+K+FE + E WYGT+Y E+IS++ IK W+N LN LP +N++IPT+F I +D SYP L++D +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I+ K+ TF D K+F+++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN ALS+M VE ++ +PLL SQL RE+ +P+ YV+ N + Y Q Q+T ++++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + +MS+E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L+K +I+ +Y + D+ K+SV+V S EM + + P ++D+ FK SLPL PL K
Sbjct: 411 YPLEEILAAEYMLEDFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDKTEEWYGTQYKQESISDEVIKKWQNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSYPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTIYGMYLSVKGYNDKQHILLKKIVEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALSMMQMVEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQTTHDNMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMSDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLSKDNIMQFYRDLLAIDAPKRHKVSVHVLSREMDSCPVVGEFPAQNDVNLAPAPSLPQPVLVQDMTEFKRSLPLFPLAK 976
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253]) HSP 1 Score: 384.03 bits (985), Expect = 1.799e-114 Identity = 208/595 (34.96%), Postives = 329/595 (55.29%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------------ESNANGPNATTIEDIVRFKTSLPLSPLIK 3789
+ L + FRF++ + S+++ + Y E IL Y++ +FRPDLI+ +++ L P ++V V+K+FE + E WYGT+Y E+IS++ IK W+N LN LP +N++IPT+F I +D SYP L++D +S+ WF QD + LPK+ ++ F + DP M ++ + L D + E Y A LA L + I++ + + ++ GYN+K + + I+ K+ TF D K+F+++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E L++GN ALS+M VE ++ +PLL SQL RE+ +P+ YV+ N + Y Q Q+T ++++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FL + + +MS+E FQK++ AL + L+KPK + + KYWGEI YNF R+ EV+ L L+K +I+ +Y + D+ K+SV+V S EM + + P ++D+ FK SLPL PL K
Sbjct: 409 KDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYMLEDFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDKTEEWYGTQYKQESISDEVIKKWQNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSYPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSRYLYADPLHCNMTYLFLRLVKDDLKEYTYAARLAGLNYGISSAMNAILLSVKGYNDKQHILLKKIVEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALSMMQMVEDTLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQTTHDNMLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMSDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLSKDNIMQFYRDLLAIDAPKRHKVSVHVLSREMDSCPVVGEFPAQNDVNLAPAPSLPQPVLVQDMTEFKRSLPLFPLAK 1003
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: nrd1a (nardilysin convertase [Source:NCBI gene;Acc:103040156]) HSP 1 Score: 213.772 bits (543), Expect = 4.570e-56 Identity = 165/620 (26.61%), Postives = 293/620 (47.26%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWEN-IKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKL---LSCLIAE-VMWTH-EDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDV--ETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKPSEL-DMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS----EMTHGSIESNANGPN----------------------ATTIEDIVRFKTSLPLSPLIK 3789
QK++ FR++E +D V + +M ++ E L G ++ E++P++I +N L P ++ + ++ E +C +E W+GT+Y VE+I +D+ + W +LN L LPAENQ+I T+FT+K++ + YP + N W+ +D + +PK++I + + + P V+ + V++ +V E Y A +A LE+ + HGL I G+N K+ + N I+ L F + F + E + N L + EKL + LI E W+ + + + +T++ + F + + EGL+ GNF S E+ + + + F K P+L R + LP+ + +N S + Y Q ++ R +++L M EP F+ LRT E LGY V + + ++ + G + + Q+ K +EL +M++ EFL SF + +S+E F+ VTAL + + + ++ W E+ Y F R +E+ L +TK +++N+ F+ + +KLS++V E + E G + AT I DI+ F +SL L P K
Sbjct: 482 QKIEANEFRYQEQTDPIEYVEDVCENMQLFPKEDFLTGDQLLFEYKPEVISAALNLLTPDKVNLLLLSPEHEGQCPLKEKWFGTQYSVEDIQKDWQERWTGEFELNPKLQLPAENQFISTEFTLKTSDCPDTDYPVRIASNDRGCLWYKKDNKFKIPKAYIRFHLISPVVQKSPKNLVLFDLFVNILVHAVAEPAYEADVAQLEYKLLAGEHGLIIKVKGFNHKLPLLFNLIVDHLANFSAAPEVFSMFTEQLKKTYFNI-----LIKPEKLGKDVRLLILEHSRWSMIQKYQAVVEGLTVDELMEFVNSFKRELYAEGLVQGNFTSVESAEFLKYITEKLQFQKLPVEVPVL------FRVVELPQKHHLCKVKSLNKGDANSEVTVYYQSGPKNLREHTLMELLVMHMEEPCFDFLRTKETLGYHVYPTCRNTSGILGFSVTVETQATKFNTELVEMKIEEFLQSFGEKLSSLSDEAFKSQVTALVKLKGCEDTHLGEEVDRNWTEVLTQQYVFNRLNREIDALKLMTKAELVNW---FMEHRGETSRKLSIHVVGFGVEENDPPAAEGEEGGASNVSLYGEVSKLTFLPPSDTLSTATPITDIIAFTSSLSLYPYHK 1087
BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
Match: ide (insulin-degrading enzyme [Source:ZFIN;Acc:ZDB-GENE-070410-85]) HSP 1 Score: 374.015 bits (959), Expect = 2.630e-112 Identity = 212/611 (34.70%), Postives = 322/611 (52.70%), Query Frame = 1
Query: 2041 SQKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKS-NGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHG-------------SIESNANGPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
+ L M FRF++ + S I+ + Y +L Y++ EFRPDLI+ +++ L P ++ VAK FE E WY T+Y E++SE+ W+N LN+ LP +N++IPT F I E+ YP+L++D+ +S+ WF QD + LPK+ ++ F + A DP M ++ V+L DS+NE Y A LA L + + N +G+ ++ GY +K + + II K+ TF D +FE++KE R + NF +E+P A L L+ E+ WT E+L + D+T+ ++ S+ H E L +GN AL M VE + +PLL SQLT RE+ LP+ +V+ N + Y Q Q+T ++++++L QI+ EP FN LRT EQLGYIV + S+ +QG R +QS K+P L+ RV FL + + M+ + F K+ +AL + L+KPK + + K+WGEI YNF R+ EV+ L LTK D+ +Y + + D+ K+SV+V S S+ P T IED FK LPL PL+K P+ TAKL
Sbjct: 320 CKDLGTMAFRFKDKERPRNYTSHITGLLHYYPIREVLAAEYLLEEFRPDLIEMLLDKLQPHNSRIAVVAKAFEGHTDQVERWYETQYKQESVSEETFTKWQNAGLNEHFTLPMKNEFIPTIFDILPLKEENTHPYPQLIKDSAMSKLWFKQDDTFHLPKACLNFEFFSPFAYVDPLHCDMAYLYVELLKDSLNEYAYAADLAGLSYTLQNTVYGIHLSIKGYQDKQPLLLRKIIEKMATFEIDEMRFEIIKEAYLRSLSNFRAEQPHQHAMYYLRLLMTELAWTKEELRDALEDVTVSCLQAFVPQLLSRLHMECLFHGNVDKEGALETMAMVEDTLVQLAHSKPLLPSQLTRHREVQLPDGRWFVYQRRNEVHNNCGIEIYYQTDLQTTHDNMLLELFCQIVSEPCFNTLRTKEQLGYIVFSGPRRSSGVQGLRFIIQSEKQPHYLESRVEAFLHAMGRHVADMTPDAFAKHASALAVRRLDKPKKLSTECGKHWGEIISQQYNFDRDNIEVAHLKTLTKDDVFKFYQELLSVDAARRHKISVHVLSREMESCPVVGEFPCQNDVSLTPAPPLPQPTVIEDTNDFKRGLPLFPLVK----PLYGKITAKL 926
BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422]) HSP 1 Score: 123.25 bits (308), Expect = 1.157e-28 Identity = 130/588 (22.11%), Postives = 247/588 (42.01%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVD-EEMWYGTKYVVENISEDYIKAWEN-IKLNDDLFLPAENQYIPTDFTIKSNG---------EDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIR----NFDSEKPLYQAEK-----LLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYI--NNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYL--QSVKKP-SELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNAT 3732
Q ++ FRF+ + V + ++ Y A ++ G ++ +++P++I + + P + + ++ N ++ E + T+Y VE+I ++ W L+ DL LP N YI TDF++ N E S YP L+ +G W+ D +L+PK++++ + L ++ ++V + V+ ++Y AS+A L + ++ L I G+N + + ++ V DA ++ + II+ D L + E+ L C T + I+ E + + F + +GL GN + EA LM+ + PL + R LPE N++ S + Y Q + R +V+++L M EP F+ LRT LGY V + ++ + G I + QS K S ++ ++ FL + + +++++F+ V AL + + + ++ W E+ F R +KEV L+ L ++ ++ + + LS++V GS E GP T
Sbjct: 296 QHIEANDFRFQNQEEPIDTVENLFENLQRYAAHDVIVGDQLLMDYQPEVIAAATDLMTPGRANLLLLSPNHAARSDHVTEGRFNTRYSVEDIDLAWVDLWTGYFPLSLDLHLPELNPYIGTDFSLVGNHQQQQHHQQEEAESDYPWLIACDGQGSLWYKLDRTFLVPKAYLNFQLISPLIQESAENQLLLDLMVMSVSHCVSTRLYPASVARLHYRLSAGDRHLGIHCSGHNHTLPLLFRALVLSPSQLVFDAMLEQIRRSLHNAIIKPDKLGRDVRLCLLETERRSLSNRLFCATNATTTTTTTSTTNATVISAERLREFARHFLASVRVQGLAQGNLTAEEAFELMDFLCEKVGGSGTGPPL----PLTFRVSRLPEKCRRSCRLASRNHRDSGSDVTVYYQFGPCTIRENVLMELLVMHMEEPCFDFLRTKHSLGYHVYAMCRCTSGILGLSINVSCQSSKHSTSYVESKIEGFLSRYEVSLSHLTQDDFKSQVNALVSRKRCEDSHLGQEVEHNWEEVLTGQLLFCRVQKEVEALMSLRCEELSEFFSAV----RRHRRILSIHVI-----GSSEVKGEGPEVT 870
BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
Match: STE23 (Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin-degrading enzyme (hIDE); homolog Axl1p is also involved in processing of pro-a-factor [Source:SGD;Acc:S000004381]) HSP 1 Score: 228.024 bits (580), Expect = 1.127e-61 Identity = 150/551 (27.22%), Postives = 283/551 (51.36%), Query Frame = 1
Query: 2164 IMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTI-KSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFT----DSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFH-YINNQQPTSALITYLQGLEQSTRN-DVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESN----ANGPNATTIEDIVRFKTSLPLSPL 3783
++T++ PDL+ + LVP +V ++++ E+ E WYGT Y V + D IK ++ LN L LP N+++ T+F + K +G P LL + +S+ W+ +D + P+ +I ++F + A+++N M+ L+T D++ + Y+A+ A+L N + GL IT G+NEK+ + + + + +F P +FE++K+ R ++N E P Q + +I E W+ + L +T E ++ + + E LI+GN K EAL + + ++++ + ++L R LLP+ + + + + Q ++ I ++ L+ + + + L Q++ EP F+ LRT EQLGY+V S ++ RI +QS L+ R+ F +F ++ M EE+F+K+ AL + +L+K K+M + +Y IY YNF +K+ + +TK +I++Y+ +I S+ KL +++ S++ + + N A P IED+ FK++L ++P+
Sbjct: 466 LLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSA--EKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFK----LPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL---RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPV 1005
BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO37735 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEX7]) HSP 1 Score: 372.089 bits (954), Expect = 4.273e-111 Identity = 193/557 (34.65%), Postives = 318/557 (57.09%), Query Frame = 1
Query: 2020 FHFINFHSQKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMT 3690
F ++ + L E+RFRF + + V ++ + + + +L GP+++T FRPDLIK +++ LVP ++++ V+K FE K E WYGT+Y +E I + IK W+N+ LN L +P +N++IPTD I+ P D+ L++ WF QD +LLPK+ + ++ LA DP M ++ + L DS+NE Y+A +A + ++++N +G+ ++ GYN K + + I+ ++ F D +F L+KE + +RNF +E+P A S L+ E+ W ++L+ + ++T+E ++ + H E L++GN EAL L++ +E+IF++ +PLL QL REI LP H +N+ S++ Y Q Q TR++++++L Q++ E FN LRT EQLGYIV + N QG R +QS K+PS LD RV FL + +I M++EEF+ ++ AL + L+KPK + + K+WGEI YNF R+ EV+ L LTK D++N+Y + P + KL+V++ T
Sbjct: 364 FEWVFEECKALAEVRFRFNDKETPRSYVCHLARSLHDFSIDDVLRGPHLLTSFRPDLIKQVLDNLVPEKVRITIVSKAFEGKTDKTEEWYGTEYSMERIDQQQIKDWKNVSLNAALTIPKKNEFIPTDLDIR---------PAPGEDSPLTKVWFKQDVTFLLPKACMLFEITSPLAYIDPCHCNMAYIFLQLLKDSLNEYAYDAEIAGVTYNLDNTMYGIFMSIRGYNHKQGILMEKILKRMTKFKVDPNRFRLIKERYEQGLRNFKAEQPHQHALYYTSYLLEELAWHKDELIDALEEVTIEKLQAFIPQLLGRLHIECLLHGNVTEKEALGLVDTMESIFTENSGTKPLLPLQLRRHREIQLP-------HTVNHVHSNSSIEIYYQCDLQETRSNMLLELFCQVIHESCFNILRTQEQLGYIVFSGPRRGNGAQGLRFIIQSDKEPSLLDSRVEVFLDKTKEMIESMTDEEFKNHIDALAVRRLDKPKKLRTETQKHWGEILTRQYNFDRDNVEVAFLRTLTKDDLLNFYKDLLEPSAPRRHKLAVHILPNTT 904
BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO31509 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXQ6]) HSP 1 Score: 224.557 bits (571), Expect = 2.736e-60 Identity = 162/611 (26.51%), Postives = 288/611 (47.14%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLK--SQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDM---RVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYV---------------TSEMTHGSIESN--------ANGPNATTIEDIVRFKTSLPLSPLIK 3789
++E FRF+E D V + +M ++ E L G +M EF ++I N N L P + + ++ ++ +C D E W+ T + + +++ W+N+ LND+L LPA+N+YI TDFTIK + +P ++++ R W +D + P+S F +++ + V+ + + + ++ E Y A +A L + ++ G+ + G+N K+ + I+ F D + F++VK R N + KP + ++ + WT D + I DIT+E S+ ++F S+ + E LI GN S EA++L E I+ KY L+ S + R + LP +N + S +I Y Q + + ++L +M EP F+ LRT EQLGY V C+ + + + G + +Q+ + ++ R+ F+ FR I+ K SEE+F+ V +L + + + ++ W E+ Y F R KEV L K+TK++++N + ++ KLSV + T E+ +G E G + +I +I FK S P+ P++K
Sbjct: 348 HAIEENEFRFQEQCDPYEFVENVVENMQLFPEEDYLTGDQLMWEFNEEVISNAANLLTPEKANIMLSSQTYKEECTDTEPWFQTPFNCSELDPKWVEIWQNLDLNDELHLPAKNEYIATDFTIKDPSDSPIKFPVTVQESPCGRVWHYKDEKFRTPRSRYYFHFISSIVNESSQSMVLTEVFLKVLEYNLREVAYAAGVAQLSYSMSVHETGIVLRLSGFNHKLPLLFQTIVDYFTNFTVDFQTFDMVKRELMRTYSN-TAIKPNKLIRSVRLAILQHIKWTTVDKRAAIPDITMETLESFVRMFQSKLYIESLIQGNVTSEEAIALQ---EVIYRKYLCYNVLIGSLSGVVQIRVVQLPRGECICRIPGMNKEDSNSVVIHYYQYGAATVEDFARLELLMMMMEEPCFDILRTREQLGYSVSCTCRNTFGVLGFSVSVQTQAEKFSVEHVASRINAFIDEFREILEKTSEEDFKSQVDSLIEIKRHDDLCLADEADRNWYEVLDQTYLFDRRTKEVEALSKVTKSELLNCFVSYV-SGGDHYSKLSVQIVGSGESENTLPSPDSTMEVDNGLGEKEEWVLRPVPVEGKDFISITNIEEFKRSRPIFPVLK 953
BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO28044 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7K7]) HSP 1 Score: 108.997 bits (271), Expect = 2.225e-26 Identity = 63/232 (27.16%), Postives = 108/232 (46.55%), Query Frame = 1
Query: 2242 VAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLR-DNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGL-----------------------------------------------KITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKE 2793
V+K FE K E WYGT+Y +E I + IK W+N+ LN L +P +N++IPTD I+ + S +P L++ + ++ F QD +LLPK+ + ++ LA DP M ++ + L DS+NE Y+A +A + ++++N +G+ ++ GYN K + + I+ ++ F D +F L+KE
Sbjct: 4 VSKAFEGKTDKTEEWYGTEYSMERIDQQQIKDWKNVSLNAALTIPKKNEFIPTDLDIRPAPGETSQFPVLIKVVSPVTNDLFKQDVTFLLPKACMLFEITSPLAYIDPCHCNMAYIFLQLLKDSLNEYAYDAEIAGVTYNLDNTMYGIFVSHANGHIWIKSRDGIFVCHAKHNVFKILGIMIHHVLNLCNTRETPCMSIRGYNHKQGILMEKILKRMTKFKVDPNRFRLIKE 235
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101158223]) HSP 1 Score: 398.282 bits (1022), Expect = 1.126e-119 Identity = 215/595 (36.13%), Postives = 337/595 (56.64%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS-EMTHGSI------------ESNANGPNATTIEDIVRFKTSLPLSPLIK 3789
+ L ++ FRF++ + S+++ + Y E +L Y++ EFRPDLI+ +++ L+P ++V V+K+FE + E WYGT+Y E IS + I+ W + LN LP +N++IPT+F I +D S P L++DN +S+ WF QD + LPK+ ++ F + A DP M ++ ++L DS+NE Y A LA L +D+ N +G+ ++ GYN+K + + I+ K+ +F + ++F+++KE R + NF +E+P A L L+ EV WT ++L ++D+TL ++ S+ H E LI+GN ALS+M VE +++ +PLL SQL RE+ +P+ +V+ N + Y Q QST ++++++L QI+ EP FN LRT EQLGYIV + +N +QG R +QS K P L+ RV FLLS ++ +MSEE FQK++ AL + L+KPK + + K+WGEI YNF R+ EV+ L LTK I+N+Y + + + K+SV+V S EM I + P T I+D+ FK SLPL PL K
Sbjct: 411 KDLSKVAFRFKDKERPRGYTSKVAGLLHYYPLEEVLAAEYLLEEFRPDLIEMVLDKLLPENVRVAVVSKSFEGQTDRAEEWYGTQYKQEAISNETIQKWASADLNGKFKLPMKNEFIPTNFEIYPPPKDSPSVPTLIKDNAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLNYDLQNTVYGMYLSVKGYNDKQHILLKKIVEKMASFEINERRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIETLIHGNITKESALSMMQMVEDTLTEHAHTKPLLPSQLIRYREVQVPDGGWFVYQQRNEVHNNCGIEIYYQTDMQSTHDNMMLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLLSMEKLLEEMSEEAFQKHIQALAIRRLDKPKKLSAECAKHWGEIISQQYNFDRDNIEVAHLKTLTKEAIMNFYRERLTVQALKRHKVSVHVLSREMDSCPIVGEFPSQNDFNLAPAPSLPQPTLIQDMTEFKRSLPLFPLAK 1005
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101157559]) HSP 1 Score: 372.089 bits (954), Expect = 8.056e-111 Identity = 198/596 (33.22%), Postives = 329/596 (55.20%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYV-------------TSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKSVL 3798
LKE+ FRF + + +++ + Y E +L G + M +FRPDLI+ ++ L P ++V V+K+FE + E WYGT+Y E I ++ I+ W N LN + LP +N +IP++F ED + P L+++ LSR WF QD + LPK F + DP + M + L D +NE Y A LA L++DI+ + + ++ GY++K + + II K+V+F + +F+++KE R + NF +E+P+ A + L+ E+ WT E+L+ ++D++L ++ S+ H E LI+GN AL ++ VE +++ +PL +QL RE+ +P+ +V N ++ Y Q QST ++++++L QI+ EP +N LRT EQLGY V + ++ +QG RI +QS + P L+ RV FLLS ++ +MSEE FQK++ AL + L+KPK + + K+WGEI Y F R+ EV L L K +I++++ + + S +KLSV++ +S+ T GS+ ++ P I+D+ FK SLPL PL+++ +
Sbjct: 305 LKEVAFRFCDKERPRDYAYRVAGSLHYYPIEEVLSGKFTMDQFRPDLIQTVLQKLTPDNVRVTVVSKSFEGQTDRTEEWYGTQYKEEAIPDEVIQKWSNPGLNPNFRLPTKNDFIPSNFETFPVEEDAPAVPTLIKNTDLSRLWFKQDDTFRLPKLCQYFAFFSRHLYTDPLHWNLTDMFIRLLKDDLNEYTYAAELAGLKYDISPQRNAITLSVRGYSDKQHILLQKIIEKMVSFQINQTRFDIIKEEYSRHLSNFRAERPITHAAFNVRLLMTELAWTKEELIEALDDVSLPRLQAFRAQLLSRLHIEALIHGNITKESALRMVQMVEDTLTEHAHTKPLPPNQLVFFREVQMPDGGWFVHQQRNEVHKDCSIEIYYQTDMQSTHSNMLLELLCQIIKEPCYNTLRTKEQLGYSVSSGARRADGVQGLRISIQSKQAPHYLESRVEAFLLSMEKLLEEMSEEAFQKHIQALAIRRLDKPKKLSAECAKHWGEITSRQYQFDRDNMEVEHLKTLRKDNILDFFSEQLTTRSPKRRKLSVHILSREMDACPAGGGSSQQTDGSLAPASSPPQPVVIQDMTDFKRSLPLFPLVQASI 900
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101157559]) HSP 1 Score: 372.474 bits (955), Expect = 1.413e-110 Identity = 198/594 (33.33%), Postives = 328/594 (55.22%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYV-------------TSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKS 3792
LKE+ FRF + + +++ + Y E +L G + M +FRPDLI+ ++ L P ++V V+K+FE + E WYGT+Y E I ++ I+ W N LN + LP +N +IP++F ED + P L+++ LSR WF QD + LPK F + DP + M + L D +NE Y A LA L++DI+ + + ++ GY++K + + II K+V+F + +F+++KE R + NF +E+P+ A + L+ E+ WT E+L+ ++D++L ++ S+ H E LI+GN AL ++ VE +++ +PL +QL RE+ +P+ +V N ++ Y Q QST ++++++L QI+ EP +N LRT EQLGY V + ++ +QG RI +QS + P L+ RV FLLS ++ +MSEE FQK++ AL + L+KPK + + K+WGEI Y F R+ EV L L K +I++++ + + S +KLSV++ +S+ T GS+ ++ P I+D+ FK SLPL PL+++
Sbjct: 376 LKEVAFRFCDKERPRDYAYRVAGSLHYYPIEEVLSGKFTMDQFRPDLIQTVLQKLTPDNVRVTVVSKSFEGQTDRTEEWYGTQYKEEAIPDEVIQKWSNPGLNPNFRLPTKNDFIPSNFETFPVEEDAPAVPTLIKNTDLSRLWFKQDDTFRLPKLCQYFAFFSRHLYTDPLHWNLTDMFIRLLKDDLNEYTYAAELAGLKYDISPQRNAITLSVRGYSDKQHILLQKIIEKMVSFQINQTRFDIIKEEYSRHLSNFRAERPITHAAFNVRLLMTELAWTKEELIEALDDVSLPRLQAFRAQLLSRLHIEALIHGNITKESALRMVQMVEDTLTEHAHTKPLPPNQLVFFREVQMPDGGWFVHQQRNEVHKDCSIEIYYQTDMQSTHSNMLLELLCQIIKEPCYNTLRTKEQLGYSVSSGARRADGVQGLRISIQSKQAPHYLESRVEAFLLSMEKLLEEMSEEAFQKHIQALAIRRLDKPKKLSAECAKHWGEITSRQYQFDRDNMEVEHLKTLRKDNILDFFSEQLTTRSPKRRKLSVHILSREMDACPAGGGSSQQTDGSLAPASSPPQPVVIQDMTDFKRSLPLFPLVQA 969
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101157559]) HSP 1 Score: 372.474 bits (955), Expect = 1.471e-110 Identity = 198/594 (33.33%), Postives = 328/594 (55.22%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYV-------------TSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKS 3792
LKE+ FRF + + +++ + Y E +L G + M +FRPDLI+ ++ L P ++V V+K+FE + E WYGT+Y E I ++ I+ W N LN + LP +N +IP++F ED + P L+++ LSR WF QD + LPK F + DP + M + L D +NE Y A LA L++DI+ + + ++ GY++K + + II K+V+F + +F+++KE R + NF +E+P+ A + L+ E+ WT E+L+ ++D++L ++ S+ H E LI+GN AL ++ VE +++ +PL +QL RE+ +P+ +V N ++ Y Q QST ++++++L QI+ EP +N LRT EQLGY V + ++ +QG RI +QS + P L+ RV FLLS ++ +MSEE FQK++ AL + L+KPK + + K+WGEI Y F R+ EV L L K +I++++ + + S +KLSV++ +S+ T GS+ ++ P I+D+ FK SLPL PL+++
Sbjct: 376 LKEVAFRFCDKERPRDYAYRVAGSLHYYPIEEVLSGKFTMDQFRPDLIQTVLQKLTPDNVRVTVVSKSFEGQTDRTEEWYGTQYKEEAIPDEVIQKWSNPGLNPNFRLPTKNDFIPSNFETFPVEEDAPAVPTLIKNTDLSRLWFKQDDTFRLPKLCQYFAFFSRHLYTDPLHWNLTDMFIRLLKDDLNEYTYAAELAGLKYDISPQRNAITLSVRGYSDKQHILLQKIIEKMVSFQINQTRFDIIKEEYSRHLSNFRAERPITHAAFNVRLLMTELAWTKEELIEALDDVSLPRLQAFRAQLLSRLHIEALIHGNITKESALRMVQMVEDTLTEHAHTKPLPPNQLVFFREVQMPDGGWFVHQQRNEVHKDCSIEIYYQTDMQSTHSNMLLELLCQIIKEPCYNTLRTKEQLGYSVSSGARRADGVQGLRISIQSKQAPHYLESRVEAFLLSMEKLLEEMSEEAFQKHIQALAIRRLDKPKKLSAECAKHWGEITSRQYQFDRDNMEVEHLKTLRKDNILDFFSEQLTTRSPKRRKLSVHILSREMDACPAGGGSSQQTDGSLAPASSPPQPVVIQDMTDFKRSLPLFPLVQA 969
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101157559]) HSP 1 Score: 372.859 bits (956), Expect = 3.592e-110 Identity = 198/596 (33.22%), Postives = 329/596 (55.20%), Query Frame = 1
Query: 2050 LKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYV-------------TSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKSVL 3798
LKE+ FRF + + +++ + Y E +L G + M +FRPDLI+ ++ L P ++V V+K+FE + E WYGT+Y E I ++ I+ W N LN + LP +N +IP++F ED + P L+++ LSR WF QD + LPK F + DP + M + L D +NE Y A LA L++DI+ + + ++ GY++K + + II K+V+F + +F+++KE R + NF +E+P+ A + L+ E+ WT E+L+ ++D++L ++ S+ H E LI+GN AL ++ VE +++ +PL +QL RE+ +P+ +V N ++ Y Q QST ++++++L QI+ EP +N LRT EQLGY V + ++ +QG RI +QS + P L+ RV FLLS ++ +MSEE FQK++ AL + L+KPK + + K+WGEI Y F R+ EV L L K +I++++ + + S +KLSV++ +S+ T GS+ ++ P I+D+ FK SLPL PL+++ +
Sbjct: 376 LKEVAFRFCDKERPRDYAYRVAGSLHYYPIEEVLSGKFTMDQFRPDLIQTVLQKLTPDNVRVTVVSKSFEGQTDRTEEWYGTQYKEEAIPDEVIQKWSNPGLNPNFRLPTKNDFIPSNFETFPVEEDAPAVPTLIKNTDLSRLWFKQDDTFRLPKLCQYFAFFSRHLYTDPLHWNLTDMFIRLLKDDLNEYTYAAELAGLKYDISPQRNAITLSVRGYSDKQHILLQKIIEKMVSFQINQTRFDIIKEEYSRHLSNFRAERPITHAAFNVRLLMTELAWTKEELIEALDDVSLPRLQAFRAQLLSRLHIEALIHGNITKESALRMVQMVEDTLTEHAHTKPLPPNQLVFFREVQMPDGGWFVHQQRNEVHKDCSIEIYYQTDMQSTHSNMLLELLCQIIKEPCYNTLRTKEQLGYSVSSGARRADGVQGLRISIQSKQAPHYLESRVEAFLLSMEKLLEEMSEEAFQKHIQALAIRRLDKPKKLSAECAKHWGEITSRQYQFDRDNMEVEHLKTLRKDNILDFFSEQLTTRSPKRRKLSVHILSREMDACPAGGGSSQQTDGSLAPASSPPQPVVIQDMTDFKRSLPLFPLVQASI 971
BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Match: SMESG000016400.1 (SMESG000016400.1) HSP 1 Score: 1225.31 bits (3169), Expect = 0.000e+0 Identity = 598/610 (98.03%), Postives = 602/610 (98.69%), Query Frame = 1
Query: 2002 LVCTNQFHFINFHSQKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 3831
L C +I+ ++KLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL
Sbjct: 364 LKCQEPQEWIHNETRKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDFTIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQVYNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVMWTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEALSLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYVFHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRSIIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTSEMTHGSIESNANGPNATTIEDIVRFKTSLPLSPLIKSVLPPVKKMPTAKL 973
BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Match: SMESG000041455.1 (SMESG000041455.1) HSP 1 Score: 139.813 bits (351), Expect = 4.079e-33 Identity = 130/574 (22.65%), Postives = 259/574 (45.12%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDF--------------TIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQV----YNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVM----WTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEAL-SLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRS----IIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS 3681
+++K F F+E + +V ++ ++ ++E++HIL G I+ E++P+L + +++ L P + V ++++FE + WY KY V +E + W + + +L LP EN++I ++F +K+ +S Y E+ W+ D + +PK+ I+ + + +P MN + D ++N+Q+ Y+AS+A L++ + G+ + G+N+K+ + I+ D K ++ KE+ +I RN + + EK + +++ W + L + ++TL++F ++ + F +GN EA M V T+ ++ P S R L+P N + +N +A++ Q + + I + + ++ EP F+ LRT E LGY VG + G +Y+ S +D + L F + II K+SE++F+ + + L M ++ W EI+ + F R K V + + K D++ ++ + Y D +KL+V + +
Sbjct: 395 KQIKYNEFLFKEVDEPVEVVENLAVNLQLFESQHILSGTDIVYEYKPELYQEMLSRLTPNLVNVMLLSRSFEPLANNTTDWYDVKYSVRQFTEHELNEWNHPLVIPELHLPDENKFIASNFNLLDITGIDEVPINVVKAEFPQLSCYGEM---------WYKLDDKFRIPKAIINFYLCSPMLSENP----MNLCLTDFILYALNQQLSTVAYDASVAGLDYKVMYQDSGILVKIDGFNDKIYLLFTTIMDFFKNLTIDESKLQVYKESLRQIYRNM-----VIKTEKFAGLIQKKILFPNEWLATEKLQYLKNLTLQDFTNFHQKLFKSMRILSYFHGNMSMQEAKECFMYCVNTL-----QLEPSETIAKASIR--LIPVGVNRIRLLSLNPYDVNTAIMIDYQIGPGTVQKQAINEFLSHVLSEPCFDFLRTKETLGYSVGLFDTKKRGILGMCLYVMSQVNKFSVDHCHDKINLFFHTMALEIIEKLSEDDFEDFKASFLSNKLIDDIQMSNIESRNWKEIFHQEFVFDRRYKHVEYIEDINKKDLVAFFSEH-YLDEGNRRKLAVEIDA 942
BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Match: SMESG000041455.1 (SMESG000041455.1) HSP 1 Score: 139.428 bits (350), Expect = 4.378e-33 Identity = 130/574 (22.65%), Postives = 259/574 (45.12%), Query Frame = 1
Query: 2044 QKLKEMRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINCLVPTQMKVYCVAKNFESKCVDEEMWYGTKYVVENISEDYIKAWENIKLNDDLFLPAENQYIPTDF--------------TIKSNGEDISSYPELLRDNGLSRWWFSQDAVYLLPKSFISITFSNTLAVRDPFATVMNFMIVDLFTDSVNEQV----YNASLANLEFDINNVSHGLKITFMGYNEKMSVFVNDIIGKLVTFVPDAKKFELVKENRFRIIRNFDSEKPLYQAEKLLSCLIAEVM----WTHEDLLSTINDITLENFHSYFKIFFSQFHTEGLIYGNFKSNEAL-SLMNDVETIFSKYFRVRPLLKSQLTSTREILLPENSNYV-FHYINNQQPTSALITYLQGLEQSTRNDVIIKLSNQIMFEPLFNQLRTLEQLGYIVGCSIKMSNSMQGHRIYLQSVKKPSELDMRVIEFLLSFRS----IIMKMSEEEFQKYVTALKDKILEKPKDMMRQFNKYWGEIYCYHYNFKREEKEVSELVKLTKTDIINYYDKFIYPDSKVLKKLSVYVTS 3681
+++K F F+E + +V ++ ++ ++E++HIL G I+ E++P+L + +++ L P + V ++++FE + WY KY V +E + W + + +L LP EN++I ++F +K+ +S Y E+ W+ D + +PK+ I+ + + +P MN + D ++N+Q+ Y+AS+A L++ + G+ + G+N+K+ + I+ D K ++ KE+ +I RN + + EK + +++ W + L + ++TL++F ++ + F +GN EA M V T+ ++ P S R L+P N + +N +A++ Q + + I + + ++ EP F+ LRT E LGY VG + G +Y+ S +D + L F + II K+SE++F+ + + L M ++ W EI+ + F R K V + + K D++ ++ + Y D +KL+V + +
Sbjct: 391 KQIKYNEFLFKEVDEPVEVVENLAVNLQLFESQHILSGTDIVYEYKPELYQEMLSRLTPNLVNVMLLSRSFEPLANNTTDWYDVKYSVRQFTEHELNEWNHPLVIPELHLPDENKFIASNFNLLDITGIDEVPINVVKAEFPQLSCYGEM---------WYKLDDKFRIPKAIINFYLCSPMLSENP----MNLCLTDFILYALNQQLSTVAYDASVAGLDYKVMYQDSGILVKIDGFNDKIYLLFTTIMDFFKNLTIDESKLQVYKESLRQIYRNM-----VIKTEKFAGLIQKKILFPNEWLATEKLQYLKNLTLQDFTNFHQKLFKSMRILSYFHGNMSMQEAKECFMYCVNTL-----QLEPSETIAKASIR--LIPVGVNRIRLLSLNPYDVNTAIMIDYQIGPGTVQKQAINEFLSHVLSEPCFDFLRTKETLGYSVGLFDTKKRGILGMCLYVMSQVNKFSVDHCHDKINLFFHTMALEIIEKLSEDDFEDFKASFLSNKLIDDIQMSNIESRNWKEIFHQEFVFDRRYKHVEYIEDINKKDLVAFFSEH-YLDEGNRRKLAVEIDA 938 The following BLAST results are available for this feature:
BLAST of Insulin-degrading enzyme vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 4
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Insulin-degrading enzyme vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003949 ID=SMED30003949|Name=Insulin-degrading enzyme|organism=Schmidtea mediterranea sexual|type=transcript|length=3890bpback to top protein sequence of SMED30003949-orf-1 >SMED30003949-orf-1 ID=SMED30003949-orf-1|Name=SMED30003949-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=592bp MRFRFRENSDLQILVSQISHDMGIYEAEHILEGPYIMTEFRPDLIKNIINback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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