AAA domain-containing protein

Overview


Name	AAA domain-containing protein
Smed ID	SMED30003935
Length (bp)	5304

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of AAA domain-containing protein (SMED30003935) t-SNE clustered cells

Violin plots show distribution of expression levels for AAA domain-containing protein (SMED30003935) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of AAA domain-containing protein (SMED30003935) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for AAA domain-containing protein (SMED30003935) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30003935

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head	SMED30003935	SMESG000012845.1	SmedASXL_017742	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
head	SMED30003935	SMESG000012845.1	dd_Smed_v6_9637_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
epidermis	SMED30003935	SMESG000012845.1	dd_Smed_v4_9637_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
dorsal region of the epidermis	SMED30003935	SMESG000012845.1	dd_Smed_v4_9637_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
ventral epidermis	SMED30003935	SMESG000012845.1	dd_Smed_v4_9637_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Human
Match: NWD2 (NACHT and WD repeat domain containing 2 [Source:HGNC Symbol;Acc:HGNC:29229])

HSP 1 Score: 146.362 bits (368), Expect = 2.557e-34
Identity = 215/995 (21.61%), Postives = 411/995 (41.31%), Query Frame = 1

Query:   40 TSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCV--------EPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSP-VIFNREIIDIKNFI----------VISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKF---GCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHD----SECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSF-----QQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEF--------NIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWY----KRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--------------------------VDQTISF----HFDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDL----DSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            T+LP  +  +P    +  F+ ++ ED   ER+ L   ++PKL+E C + +G+E ++ID+  G++     +   Q+   + L          C + LLG+KYGN+  P  +    F+++L+     K    +E   LE++Y  D N V        + EM+  +  A+ P    ++       ++ W++    +  +F+   K+    G +      +   +  E  F   + K   +     V + R+I +I+ F+          +   + +  +   A EKLI +       +V + +L+      +      Y        I      G+ +  ++  ID  +A I             + N D     L  YD I         +A F    C   +IV+  +        N P+I+YG P +GK+++ A    +    L  D    S+   I RF+ +   ++    ++ L +          E +  N + +  + P+ I  +   F     +    +  +II    E+ SE    +     +P  LP+ +++++S+  +          ++  E    E         +  ++ QL    + +T  Q + +++N L       T  + V+  + +   + S +++   +L      ++ + +    K+ G+ L+S  L YI  +  GL++ E+ +VL LD  VM+E+  N   S     + ++ P      +K+ LS  L++  +K+  LLV  +    +  + L    ++ L++ H ILA YF G W                          +++   F     FD + P+  +   C P    ++       F N+RK  +L+ HL      D+L+  +I +F +LY   K  +  ++L D +LA N  +E  L  + + N+   I+N +     SL+ EL  +LLP VS  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:   28 TALP--SHLVPAGRSVRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAIEAK----LETKLLEEWYCRDENSVPAAYYLRPKSEMLRSNRNAMQPSTNAEN-------EKTWQEISDEIKKIFKAAVKLLHEKGKMKHSQAKRYLFSAIEDEFDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIKLRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYI-----EGLGKQFYEDMIDIIQATI-------------QQNFDTETDTL--YDEILQHSSLCKTYASFYEYKCESLNIVHNYILPSKAGHIN-PLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTT-DMSSDLRTLLLSVC---------EQLAVNYRCLVQSYPKKIHDLCDLFINLLNESSLQRPLVIIFDALEQLSE-NDDARKLWWLPAHLPRFVRIVLSTLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQ-QIYVNNALSKC----TLPMFVNLTFREVRHWRSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELEDVLALDNSVMSELKENTRPS-----NPLRVPYLYIARLKEGLSGYLIERHVKNVTLLVWANRHLQLIAQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIF-------FVNHRKMSELLYHLTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLSDIELAYNYSQEKEL--KFLANTLRSIKNKVTAFPGSLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 958

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 90.5077 bits (223), Expect = 2.429e-17
Identity = 89/376 (23.67%), Postives = 169/376 (44.95%), Query Frame = 1

Query: 1876 IPCQTLGEFYALNL-NRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDD--KNSHLKDFHQILAGYFNGAWVDQT---ISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIE---NDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAP-----KHNAFVPIYPSNKLPGSPLASTIN-CPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            +P  T  E     L  R  +  G+ L++H L YI  S  GL++ E+ +VL+LD +V+ +VY + +      + +++FP  LW+ ++++L   L     DG+ L+ +A    VE + +     S     H +LA +F+G W   T   I+     K   +     P  Q ++     +   N RK ++L  HL+     +EL + V+    ++  +  +  + +LLDDF L        E+ L+ E++      +E    +   L  EL+ +L  + + +P L  + + C +         H   VP+    + PG PL +T++ C + I ++        + ++LL+    D     +D+    + +     +GEV
Sbjct:  553 VPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPP---SKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAP--QPLWFS---HTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPAL--VGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAM-----AWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEV 913

HSP 2 Score: 67.3958 bits (163), Expect = 2.577e-10
Identity = 82/398 (20.60%), Postives = 161/398 (40.45%), Query Frame = 1

Query:  148 RIFPKLQEQCF-DEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKC-YDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDT--NVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
            R  P L+ Q F    G+  +++D++ G+ +   T     ++  E +++   C K +  P F  L+G +YG    P  IP++I +   E L++H      +   + +Y+  D N   P  +L            Q   +   C+ E     S+L +  Q   ++    G +  E       +  E     ++  S D +    +F REI D+   I+      +D     +++L        AD  ++ D Q++L    +   +++       R+ W RD        H  Y+ +       +    V  R ++  LD +   L   Y  I +   Q ++  +  CG ++++  +   L  DD+  + P++L+GPP  GK+ +  +   +    L H +
Sbjct:    8 RALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDR---CWKTSIGPAFVALIGDQYG----PCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVL------------QAPGTGEACEPEEATLTSVLRSGAQEARRL----GLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHIL------EDCALRMVDRL--------ADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRE--LDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT 366

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 90.5077 bits (223), Expect = 2.629e-17
Identity = 89/376 (23.67%), Postives = 168/376 (44.68%), Query Frame = 1

Query: 1876 IPCQTLGEFYALNL-NRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDD--KNSHLKDFHQILAGYFNGAWVDQT---ISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIE---NDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAP-----KHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            +P  T  E     L  R  +  G+ L++H L YI  S  GL++ E+ +VL+LD +V+ +VY + +      + +++FP  LW+ ++++L   L     DG+ L+ +A    VE + +     S     H +LA +F+G W   T   I+     K   +     P  Q ++     +   N RK ++L  HL+     +EL + V+    ++  +  +  + +LLDDF L        E+ L+ E++      +E    +   L  EL+ +L  + + +P L  + + C +         H   VP+    + PG PL +T+  C + I ++        + ++LL+    D     +D+    + +     +GEV
Sbjct:  553 VPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPP---SKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAP--QPLWFS---HTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPAL--VGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAM-----AWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEV 913

HSP 2 Score: 67.3958 bits (163), Expect = 2.883e-10
Identity = 82/398 (20.60%), Postives = 161/398 (40.45%), Query Frame = 1

Query:  148 RIFPKLQEQCF-DEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKC-YDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDT--NVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
            R  P L+ Q F    G+  +++D++ G+ +   T     ++  E +++   C K +  P F  L+G +YG    P  IP++I +   E L++H      +   + +Y+  D N   P  +L            Q   +   C+ E     S+L +  Q   ++    G +  E       +  E     ++  S D +    +F REI D+   I+      +D     +++L        AD  ++ D Q++L    +   +++       R+ W RD        H  Y+ +       +    V  R ++  LD +   L   Y  I +   Q ++  +  CG ++++  +   L  DD+  + P++L+GPP  GK+ +  +   +    L H +
Sbjct:    8 RALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDR---CWKTSIGPAFVALIGDQYG----PCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVL------------QAPGTGEACEPEEATLTSVLRSGAQEARRL----GLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHIL------EDCALRMVDRL--------ADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRE--LDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT 366

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 90.5077 bits (223), Expect = 2.629e-17
Identity = 89/376 (23.67%), Postives = 168/376 (44.68%), Query Frame = 1

Query: 1876 IPCQTLGEFYALNL-NRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDD--KNSHLKDFHQILAGYFNGAWVDQT---ISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIE---NDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAP-----KHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            +P  T  E     L  R  +  G+ L++H L YI  S  GL++ E+ +VL+LD +V+ +VY + +      + +++FP  LW+ ++++L   L     DG+ L+ +A    VE + +     S     H +LA +F+G W   T   I+     K   +     P  Q ++     +   N RK ++L  HL+     +EL + V+    ++  +  +  + +LLDDF L        E+ L+ E++      +E    +   L  EL+ +L  + + +P L  + + C +         H   VP+    + PG PL +T+  C + I ++        + ++LL+    D     +D+    + +     +GEV
Sbjct:  553 VPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPP---SKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAP--QPLWFS---HTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPAL--VGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAM-----AWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEV 913

HSP 2 Score: 67.3958 bits (163), Expect = 2.883e-10
Identity = 82/398 (20.60%), Postives = 161/398 (40.45%), Query Frame = 1

Query:  148 RIFPKLQEQCF-DEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKC-YDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDT--NVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
            R  P L+ Q F    G+  +++D++ G+ +   T     ++  E +++   C K +  P F  L+G +YG    P  IP++I +   E L++H      +   + +Y+  D N   P  +L            Q   +   C+ E     S+L +  Q   ++    G +  E       +  E     ++  S D +    +F REI D+   I+      +D     +++L        AD  ++ D Q++L    +   +++       R+ W RD        H  Y+ +       +    V  R ++  LD +   L   Y  I +   Q ++  +  CG ++++  +   L  DD+  + P++L+GPP  GK+ +  +   +    L H +
Sbjct:    8 RALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDR---CWKTSIGPAFVALIGDQYG----PCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVL------------QAPGTGEACEPEEATLTSVLRSGAQEARRL----GLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHIL------EDCALRMVDRL--------ADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRE--LDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT 366

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 90.5077 bits (223), Expect = 2.629e-17
Identity = 89/376 (23.67%), Postives = 168/376 (44.68%), Query Frame = 1

Query: 1876 IPCQTLGEFYALNL-NRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDD--KNSHLKDFHQILAGYFNGAWVDQT---ISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIE---NDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAP-----KHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            +P  T  E     L  R  +  G+ L++H L YI  S  GL++ E+ +VL+LD +V+ +VY + +      + +++FP  LW+ ++++L   L     DG+ L+ +A    VE + +     S     H +LA +F+G W   T   I+     K   +     P  Q ++     +   N RK ++L  HL+     +EL + V+    ++  +  +  + +LLDDF L        E+ L+ E++      +E    +   L  EL+ +L  + + +P L  + + C +         H   VP+    + PG PL +T+  C + I ++        + ++LL+    D     +D+    + +     +GEV
Sbjct:  553 VPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPP---SKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAP--QPLWFS---HTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPAL--VGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAM-----AWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEV 913

HSP 2 Score: 67.3958 bits (163), Expect = 2.883e-10
Identity = 82/398 (20.60%), Postives = 161/398 (40.45%), Query Frame = 1

Query:  148 RIFPKLQEQCF-DEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKC-YDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDT--NVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
            R  P L+ Q F    G+  +++D++ G+ +   T     ++  E +++   C K +  P F  L+G +YG    P  IP++I +   E L++H      +   + +Y+  D N   P  +L            Q   +   C+ E     S+L +  Q   ++    G +  E       +  E     ++  S D +    +F REI D+   I+      +D     +++L        AD  ++ D Q++L    +   +++       R+ W RD        H  Y+ +       +    V  R ++  LD +   L   Y  I +   Q ++  +  CG ++++  +   L  DD+  + P++L+GPP  GK+ +  +   +    L H +
Sbjct:    8 RALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDR---CWKTSIGPAFVALIGDQYG----PCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVL------------QAPGTGEACEPEEATLTSVLRSGAQEARRL----GLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHIL------EDCALRMVDRL--------ADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRE--LDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT 366

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Celegans
Match: T05C3.2 (pep chromosome:WBcel235:V:5493747:5503010:1 gene:WBGene00020254.1 transcript:T05C3.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T05C3.2)

HSP 1 Score: 200.29 bits (508), Expect = 3.226e-51
Identity = 218/944 (23.09%), Postives = 403/944 (42.69%), Query Frame = 1

Query:  124 IERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGL-DSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIY--------PDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFR--ILWRDDTGVSEAHHQIYIDQF----EAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSN---CTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSN-----KKFIIILHDFEKCSEV-GSQSLVTDLIPKFLPKNLKLIVSSTDS-----------FDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNS----MEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLA----TTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFD---------LKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNG------GKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPL 2781
            +ER  L   I+PKL+E C + +G++ +++D++ G+ D   +     +    E  N   +    N  +FL  QKYG    P  IP++I    LE LK   +    + + L+ +Y+ D N V P  +L  I +I         P L +QD        ++W + ++ +  L +  ++ C   G LD E +   F++  E      I K  +     + + R I    N I +S  K          K +D+ ++      +N + Q +L    +       A +   R  + W    G+   +H  YI QF       IT+ V   + + A+  +   +         I  +++   +  +  C  + ++          ++ +PIIL G    GK+ + A+   + +    +  E   + RF+ ++     IA +  S+  QI++       ++  LKNS       P ++  +   F++ +N     K  +II    +  S + G+  L+    P  LP  +KL  S T              + ++ Y   ++VP   +      ++  L++ G+ L+E Q      N +       T  + V   Y     + S     E I   +L E   +  +R   + GK L+SH L YI  +  G++D EV ++++LD KV+++++  H         + + P  LW  I+ +L   L +   DG ++++        V++E    + N HL+  H  +A YF G W      + +           +N  ++    PK   +++ K GN  YN RK  +L  HL+     DEL+   +FD+++L+ K  +  +  L+ D++ A          +++ L  +++  SA ++  +   LA EL+ +LLP V+    +  L+  CDK  P+HN+FVP +     PG PL
Sbjct:  114 VERNALMEEIYPKLKEYCRETYGLDFQVVDMRWGVRDESTDDHMTTKLCLSEIANCQRLSVGANFVVFLC-QKYG--YRP--IPSEILSTELEMLKRTLREEHEDISLLDNWYIEDSNSVPPMFVLQQISSILVNFNNKRIPKLQEQD-------AKQWWECEAKMQQLLRKGARSCYEKGFLDREAMHNYFMSVTEREVVHGILKVKNPNEHCLCYIRHI----NNIALSQMK-------TASKFVDIAHNH-----VNSEAQKLLANLRDERVPAKLAMQNIRRSTVEWVGRDGIDVQYHAEYIRQFCTDFYKSITSMVDNAMEKHARFRDQLFTEVLTHLTTGITVSNMFFGRNEQLDCAKQYVL---------GNSTLPIILQGENGCGKTSLMAKIATKIREWYDNSCEPVVLLRFLGTSPDSSNIAPLLTSVCDQIAS------NYDESLKNSS------PTELSKLFQHFKKITNLATREKPLVIIFDSLDLLSRIDGAHELL--WFPPSLPPFVKLFASLTPGGSLIYSKMQRLIEDKRQY---LMVPSLGKDLGFQVVREWLSDKGRTLSERQ-----WNTVSKALDKCTLPLFVKLIYATVARWKSYSRPQETILFSSLQESINVLFHRTESQHGKLLVSHALSYISAARSGISDSEVEDLISLDDKVLDDIFQYHLPP------VRRIPPLLWSRIRSDLPGYLSERAADGVIVLNWYHQQFRQVAIERYFKNVN-HLETCHSAMAEYFLGVWGGVPKPYQYTEMQKQRFGVTENEGLADRKVPKQPNVFSSKDGNHRYNTRKLNELPYHLLRSGRVDELLTLCLFDYEFLHAKVSSFPLQSLIADYEDAIQNVRDVEISRQLSLAVDALRLSASILSRNPSMLAFELLGRLLPLVATNKYVSKLLIKCDKEGPQHNSFVPAHHCFHAPGGPL 991

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Celegans
Match: qui-1 (QUInine non-avoider [Source:UniProtKB/TrEMBL;Acc:N1NTL8])

HSP 1 Score: 53.9138 bits (128), Expect = 1.391e-6
Identity = 95/435 (21.84%), Postives = 175/435 (40.23%), Query Frame = 1

Query: 1423 FETILKNSKEIENNIPRDI------EGILLSFQ---QQSNKKFIIILHDFEKC------SEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLN--VLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLID---DKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNG--GKEIVLLEESINNSALV-IENDLDSLAGELIMQL 2658
            + TI  N   I N  P+++       GIL S +   Q+++K   I + D          S++G ++       +  P NL L ++S++       + +   V V   ++ E    +Q       K LT EQ    +   +   DGIL A       +    ++N    +     G      + R  K FGK  + + + +I  SS GLT  E+ + ++ D++V+ E+ ++   SL+    I+           + L  IL  VI D   ++ +A +  +  L +     +  ++  H  L+  F    +D   S   ++     S             K  N   N+R+ R L  H +   N D L +  +  F+Y+   T+   +S LL  ++         ++ ++ E +   ALV +  D + LA E+I +L
Sbjct:  151 WRTICLNICSISNIDPKEVLEHFKLGGILKSLEELVQKADKPVCIFIDDVHLLKFGHLLSQIGRRT-------ETAPDNLSLFMTSSNVAPVNAVFAVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNEQISA-IRPLMAAKDGILIAKS-----FTHEILFNGNSSMKGGMDGR-----MTRIEKEFGKLAVGNAVKFIAASSHGLTRLEIHDAISADREVLEEMNMSIVYSLLTLDGII-----------EALGPILRKVIIDDRQIIGIAHSGLISWLRNRYLTSSQDIRSAHLQLSDLFADLLIDNEQSPRHEIAYQSFSQGI----------KRDNGSPNFRRLRLLWYHCLHSGNLDRLKELSLCHFEYVDYVTRYFGISHLLSLYEECATQILHHDLQVISEQVLVPALVTMARDSEQLAAEVIGRL 546

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Celegans
Match: qui-1 (QUInine non-avoider [Source:UniProtKB/TrEMBL;Acc:N1NTL8])

HSP 1 Score: 53.5286 bits (127), Expect = 1.993e-6
Identity = 95/435 (21.84%), Postives = 175/435 (40.23%), Query Frame = 1

Query: 1423 FETILKNSKEIENNIPRDI------EGILLSFQ---QQSNKKFIIILHDFEKC------SEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLN--VLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLID---DKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNG--GKEIVLLEESINNSALV-IENDLDSLAGELIMQL 2658
            + TI  N   I N  P+++       GIL S +   Q+++K   I + D          S++G ++       +  P NL L ++S++       + +   V V   ++ E    +Q       K LT EQ    +   +   DGIL A       +    ++N    +     G      + R  K FGK  + + + +I  SS GLT  E+ + ++ D++V+ E+ ++   SL+    I+           + L  IL  VI D   ++ +A +  +  L +     +  ++  H  L+  F    +D   S   ++     S             K  N   N+R+ R L  H +   N D L +  +  F+Y+   T+   +S LL  ++         ++ ++ E +   ALV +  D + LA E+I +L
Sbjct:  416 WRTICLNICSISNIDPKEVLEHFKLGGILKSLEELVQKADKPVCIFIDDVHLLKFGHLLSQIGRRT-------ETAPDNLSLFMTSSNVAPVNAVFAVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNEQISA-IRPLMAAKDGILIAKS-----FTHEILFNGNSSMKGGMDGR-----MTRIEKEFGKLAVGNAVKFIAASSHGLTRLEIHDAISADREVLEEMNMSIVYSLLTLDGII-----------EALGPILRKVIIDDRQIIGIAHSGLISWLRNRYLTSSQDIRSAHLQLSDLFADLLIDNEQSPRHEIAYQSFSQGI----------KRDNGSPNFRRLRLLWYHCLHSGNLDRLKELSLCHFEYVDYVTRYFGISHLLSLYEECATQILHHDLQVISEQVLVPALVTMARDSEQLAAEVIGRL 811

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Fly
Match: CG10185 (gene:FBgn0038397 transcript:FBtr0083235)

HSP 1 Score: 149.058 bits (375), Expect = 1.838e-35
Identity = 219/945 (23.17%), Postives = 399/945 (42.22%), Query Frame = 1

Query:  124 IERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGL-DSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAI--------YPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDII-----CNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTS---NCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQ-----QSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVS-STDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLN-----NTGKLLTEEQNERFLSNYLK--FTDGILTAS--VIVDYFYNQNFIYNS----MEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLKD------FHQILAGYFNGAW---VDQTISF------HFDLKNPEMSYNC-CPKSQKMYAKKSG-NVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLA------RNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPL 2781
            +ER  L  + +P++++ C ++ G+E +++D++ G+ D   +     +    E  N   +    N  +FL GQKYG    P  I +    L+ E L +      V+   L+ +Y  D N V P  +L  I +I         P L  +D       Q  W  T + +  L +  +    ++  +  E V   F++  E      I    ++K   + + R I    N I + N KK       I + +D   +++A L+   DL+ V         +I   +  K+ + W    G+    H+ Y++ F +     VV+ V    +K   D SA      +I+     CN  ++I    +  C  E I   ML      D++ P++L+G    GK+ + ++++    +          + RF+ +   +  +    +SI  QIS   +    FE           NIP D+  +   F+Q        +   I L   ++ +     + V+  IP  LP + K+I+S + +  +    +  +VL  +    E N    T L      N  K+  +    R L+NY      + I   S  + V   + +   + S     E     T+ +   L   R  K+ G+ L+ H L YI  S  GL++ E+ ++++LD KV+++VY  H           + P  LW  I+ +L   L +   DG   V++      +     K  + K+      FH ++A Y+ G W   V +   F       F L + E S +   P    +++ K G +  YN RKF +L  H V    + +L ++V+F++D+L+ K  +  +  +L DF+ A      +   +E++L+ +++     ++    + LA +L+ +LLP +   PN++ L+  CD+  PK  A +P+      PG PL
Sbjct:   38 MERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFL-GQKYGYRPIPTYIVSSELALICEELTS----MGVDRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVPKLQAED-------QAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGILNVKNTKNHCLSYVRYI----NNINLQNLKKASLFVDIINRSLD---TESAKLL--SDLRDVRLPA-----KIEAVNAQKYTVEWIGREGLDIETHEEYLNHFISHFYKNVVKLVDRAMRK--EDSSAQGQIVTEILQHLHACNNSVKIFYGREESC--ERIKRYMLG-----DSDKPLVLFGDGGCGKTSLLSKSVSLVATEWFAHVRPINVIRFLGTTPDSSALTATLISICQQISYNYML--PFE-----------NIPDDLVPLTAHFKQLLTYASPTQPLTIYLDSVDQLTGTQDSNKVS-WIPTRLPPHCKIIISCANEPANPTVSHEYHVLC-KMIDVEENFIEVTALGEDLAMNVIKMWMKTAC-RDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERVEKQHGRILVFHALAYITASKSGLSESELEDLISLDDKVLDDVYQYHLPP------TRRIPPLLWTRIRNDLPNYLSEREADG---VNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRYNLRKFGELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKEAKRELMLVSDALRLGGAILAIYPNMLAPQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCALIPVNHCLHTPGGPL 922

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Zebrafish
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 151.754 bits (382), Expect = 4.259e-36
Identity = 228/965 (23.63%), Postives = 408/965 (42.28%), Query Frame = 1

Query:   70 PERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKY-NCPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQD------RNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVN----EFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERA---KKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIV--YAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCT-IAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVS-STDSFDTRKPYFL---NVLVPEF-TQTEFNIFIQTQLNNTGKLLTEEQNERFL------SNYLKFTDGILTASVIVDYF-YNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVD-----LATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMS--YNCCPK--SQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLD---------SLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAF-----VPIYPSNKLPGSPLASTIN 2796
            P   ++  F+ S+  D + ER     + + +LQ  C    G+  +++D K G+    + TA+   I    + +   C +  + P F  L+G +YG+ L P  IP   F+LLL  L    +        L Q++  D N + P  IL+ I   YP   ++D      R++ +I    W  T+S L  + ++ +     +G    +   K F +    E E  F  T R +     S V+F RE+  +          K D +K+  + L+DVT     D    E L  + ++  N+        +P    L +     S   H+ Y+ +    +T+++ E ++  A      ++D   S+LK  +I  +A L   K A F  G +DI+   ++  + ++D ++ P++++GPP  GK+ +  +   E ++ + +           +   + +  +   + LQ+   +   + +  I          + R    +L    +Q +   ++IL   E+  E      + D IPK +P N++++ S S +  D  K       N+   E  T+ +    I   ++   + LT EQ +  L       N L     + TA +   Y   +   +  S EE+  Q +    +L +N      GK L+SH L +I  S  GL++ E+ +VL+LD  V+ E+Y      L    ++++FP   W  ++ +LS  L +  + G LL+       A  V    L  D  +   D H ILA YF+G W    +     +  P +S   N   K   Q ++  +      N RK  +L  HL     +DEL ++V+   D+L  KT    VS ++ D  L  +     EI LL+E+     L+++  LD          L  E+  +L     +YP++  + + C +      ++     VP     + PG PL ST+ 
Sbjct:   25 PTSRMVRVFISSTHSDMKNERNAFWEKTYSELQTHC-QSLGLVFEVVDFKCGMR---DITASDHLITELCIKEIETCQRISDGPTFIALIGNQYGHRLVPRLIPEAEFELLLSKLSKDPESL----KLLNQWFYKDSNSIPPTYILLPITVHYPHYNERDSENAQLRDNDVI---SWNLTESRLLQVLRSAALQAERDGDFTADSKHKFFKSVLEYEMEHGFLRTQRDA-----SAVLFFRELPRLS---------KRDCKKNFAKFLLDVTADGLLDTQARELLTDLKQRICNTGR-----LQPLCMELSKGAMDPSRKEHKEYLGKLCEQVTSQLKELISRNALQTSGTSVDPVWSWLK-QEIFHHAKLSEEKCAVFK-GRDDILGKISITLWESNDVSHGPLLVHGPPGVGKTALLCKLAKEMRAVVDNRGVVLLRLLGTSLLSSDVDSVLRGVCLQVCGALGLQSPYSHIAYT----HEGLVRFFHSMLEDVSKQGDT-LLLILDSLEQLLETNKLHKL-DWIPKIIPPNVQIVFSTSNECLDKCKSLVSAEENIFKLELLTKDQGRDVIDAYMSAAERKLTAEQQDAILRYFEQSGNPLHLKLMLDTAKLWSSYTPMSSVHLDKSAEEVMTQFV---ESLEVNH-----GKKLVSHALSFILLSRYGLSEAELQDVLSLDNDVLAEIY---KCWLPPSHTLMRFPRFHWSRLRHDLSAHLTERWEAGVLLLGFTHRQFAELVRRRYLSRDVKA---DMHTILAEYFSGQWSKGQLR---PILLPSLSAFLNADRKVSPQPLWFSEE---LANLRKIHELPYHLAHAGKWDELRQSVLGSLDWLCCKTLQCGVSCVIQDLTLCTDLTDCPEIQLLKETF----LLLKPSLDFSDGRVDPSLLVTEIFARLQGLADHYPSM--IGQLCSQCMDWFESYSDPLLVPKCSFFEAPGGPLKSTLR 925

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Zebrafish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-161213-1])

HSP 1 Score: 90.1225 bits (222), Expect = 2.238e-17
Identity = 91/367 (24.80%), Postives = 157/367 (42.78%), Query Frame = 1

Query: 1813 TASVIVDYFYNQNFIYNSMEEIP----CQTLGE-----FYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATT---VSVESLIDDKNSHLKDFHQILAGYFNGAWVD-QTISFHFD-----------LKNPE-----MSYNCCPKSQKMYAKKSGN--------------VFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            T  + V+  Y +   + S +++     C T+ E     FY++       + G   +   L YI  +  GLT+ E+ ++L+LD  V+ ++ +  S +L   +S ++        +K+EL   LV+       L+  A     +  + L       +   H +LA YF GAW   +   FH D            +NP        ++     +  Y +++                 F N+RK  +L  HL      D+L+  VI +F +LY   K  +  + L D  LA +    KE+  L  ++ +  L +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:  610 TLPMFVNLIYREVVHWRSHKDVDDKSLCSTVHESIEQLFYSVE-----NKLGSRFVFRALGYITMARAGLTELELEDILSLDNSVLGDIMV--SSNL---KSPLRISYDFIARLKEELEGYLVERQVHNVTLMVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFHCDNNHFASLNISQHRNPHNQQSLHGHDKASADKHSYDRQTPEQPWVFQCNLLEPDIFFVNHRKMTELTYHLTRSGRTDDLMYGVIMNFSWLYTMIKIGQFDKALSDIDLAYSYTQEKELKFLATTLRSIKLKVTKNPASLSAELQQRLLPVVTSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 966

HSP 2 Score: 71.2478 bits (173), Expect = 1.357e-11
Identity = 39/144 (27.08%), Postives = 74/144 (51.39%), Query Frame = 1

Query:   67 LPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNF----LEQYYVLDVNCVEP 486
            +P    +  F+C++ +D E ER  L   ++PKL++ C + +GIE +++D+  G+D     +   Q++  + L +        C + L+G+KYG++  P  + +  F+++L+         AVE       LE++Y  D N V P
Sbjct:   35 VPTGRSVRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGIDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLIGEKYGSIRVPGEVESAEFEMILDA--------AVEAGLDTRILEEWYCRDENSVPP 170

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Zebrafish
Match: CU570791.3 (NACHT and WD repeat domain-containing protein 2-like [Source:NCBI gene;Acc:108179119])

HSP 1 Score: 63.5438 bits (153), Expect = 3.164e-9
Identity = 47/204 (23.04%), Postives = 90/204 (44.12%), Query Frame = 1

Query:   85 INFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIF---LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFE 687
            +  ++CS+ ED  +ER ++  ++FP+L+E C   +G++ ++I      D Y  T         E L     C   +   F   L+G++YG+   P ++    F+L+L+      +R   + + LE+ Y  D N + P   +++          Q  N     ++ W K    +  +  ++   C+  GTL +E   K F +  E
Sbjct:    4 VQVYLCSNPEDSVVERTLIRQKVFPRLREYCRSTYGLDFRVI------DPYEATKPKNWPTQQERLRILEDCWNNSLHSFFVGLVGEQYGDACLPEQVEASEFQLILQVC----QRMGFKTDVLEKCYRRDENTIPPSFCMLEPSRRCKQTSVQQENPTE--EKNWCKVFPEVRRILHDVVNQCIQEGTLALEKAQKYFQSSLE 195

HSP 2 Score: 60.4622 bits (145), Expect = 2.515e-8
Identity = 119/522 (22.80%), Postives = 219/522 (41.95%), Query Frame = 1

Query: 1195 DYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPH-DSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDS----FDTRKPYFLN-VLVPEFTQTE---FNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLG-EFY---ALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFP----------LSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLK-----------------NPEMSYNCCPKSQKMYAKKSGNVFY--NYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNG----GKEIVLLEESINNSALVIEND 2622
             YL   +T  P IL G P SGK+++ A    +    L + D E   +  F+  N ++ ++       +  I  R +   T + +  +++ N  R     LL+ +  S    +II+   ++  +   Q  +T L PK L  N+KL++S + +        K Y+ +  L  E  Q +    N  + T L  + + +T  Q + +++  LK      T  + V+  Y Q   ++S  EI  +TL  E +    L  +   ++ GK+L+S  L Y+  +  G+T  E+ +VL+ D +V+ E ++   E +    + ++ P          L  +L+ +  L    +  +   + LV     V  + L  ++   LK  H +L+ YF+G+W + T   HF +                  + ++    C  SQ  Y   +       N RK   L  HL+     +EL   +I   +YL     A+   EL     L +       +E+ LL   + +SA ++ N+
Sbjct:  336 SYLEGKNTLFPFILNGGPYSGKTVLLAHCASQVSVWLKNLDPE--ILVFFIDVNSSLRQL-------LKYICERADSSNTNINSIFQLKENFKR-----LLTVRSTSKNPLVIIIDGLDQLPKTDGQPDLTCL-PKALAPNVKLLISVSANRHALLAALKQYYPDSALFCELQQVDTKSCNQLLTTLLQGSNRKITSGQ-QVYVNEALKKC----TVPLYVELLYRQAVCWHSEFEITEETLDLEVHNSIVLIFDHMERKHGKSLVSKALSYLTLARYGMTTAELTDVLSCDDEVV-ESFLPQGEGV---PATLRVPEVSVETLLSDLKGFLVQRNILGTQTLSWVNRHFPLV-----VCKQYLCSEETC-LK-IHHVLSDYFSGSWANGT-KKHFIINKDTQIQSSSDVPRNIYIDRQVPSQPCIFSQPFYISTAMRTPTRPNLRKLHTLSFHLLKSGRIEELGSQMISQ-EYLQVMLHAMLADELF--LWLEKTSQLIFPRELQLLHAILKSSACLLRNN 822

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Xenopus
Match: hsp90ab1 (heat shock protein 90kDa alpha family class B member 1 [Source:Xenbase;Acc:XB-GENE-495311])

HSP 1 Score: 138.272 bits (347), Expect = 7.188e-32
Identity = 210/979 (21.45%), Postives = 390/979 (39.84%), Query Frame = 1

Query:   67 LPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYK-QDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSP-VIFNREIIDIKNFI----------VISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKI--NLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFA----RTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQS--NKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDS-----------FDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQ---NERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWY----KRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--------------------------VDQTISFH----FDLKNPE--MSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGG--KEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            +P    +  F+ S++   E ER  L   ++PKL+E C + +G+E ++ID+  G+      +   Q+     L +        C + LLG+KYG +  P  + +  F+++L+     K    +E   LE++Y  D N V P   L     +  + +   D  +    ++ W+     + ++F    K+    G L    V +   +  E  F   + K   +     V + R+I +I+  +          VI  + K  +   A+EKL  +       +V + +L+      +      Y        +      G+ +  ++  ID  +A +             +I  +L L  ++   Y+  C A   +NK+ +  C    I               P+I+YG P +GK+++ A    +     Q  +  DS+   I RF+ S  T     L+  LQ     L  N    +    K+I N     +  + L+   +S  ++  +IIL   E+ S+      +   +P  LP+ +++I+S+  +                 Y    L+P   +    I     L    K+ + +Q   NE F            T  + V+  + +   + S +++   TL      N+ + +     + G   +S  L YI  ++ GL++ E+ ++L LD  VM+EV  N    +      ++ P  +   +K++L+  LV+  +++  LLV  +    +  +         L++ H  +A YF G W                          +D+   ++    FD + PE   ++ C P    ++       F N+RK  +L+ HL      +EL+  +  +F +LY   K  +    L D  +A N    KE+  L  ++ +    I  +  SL+ EL   LLP VS  P  R L+  CDK  PK+ + VP++ S  +  SP
Sbjct:   35 IPTGRSVRVFIMSTYHT-EAERNELREHVYPKLREFCRENYGMEFQVIDLYWGIPEEDWDSPDLQKTRMRLLEECLKTSAGPCFVGLLGEKYGTIRIPGEVESSEFEMILDAAIEAK----LETRTLEEWYCRDENAVPPAYYLRPKSEMLKNHHNPGDSTTGSANEKTWRTVAEEIKHIFSTSVKLLQEKGKLKNNQVKRYLSSALEDEFDFALGKQTAAFLKKCVCYIRKISNIERHVKIPEMARYTDVIKVENKYIRDPEALEKLAKLRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEVENHYV-----DGLGKQFYEDMIDIIQATVQQNFETETDPLYDEILQHLSLCKTYASFYEYRCEALNLVNKYLR-PCRSGHI--------------YPLIIYGGPCTGKTLLLAEVAKKACSWLQEEMGPDSDPVVIVRFLGS--TDMSSALNCLLQSICEQLAVNYRCLLQSRPKKILN-----LHELFLNLLNESSFHRPLVIILDGVEQLSDSDDARKLW-WLPVHLPRTVRIIISTLPNKHGILQKLRCLIHNEDSYI--ELIPRDKKMCSQILKHQLLRVKRKVTSGQQIYVNEAF---------SKCTLPMFVNLTFREVRNWRSHKDVDGSTLCVTVHRNIEQLFWSLENKCGPRFVSRALGYITMATTGLSEVELEDILALDNTVMSEVLSNMKPYI-----PLRIPYIMIAQLKEDLTGYLVERQVRNVTLLVWANRHLQLVAQKFYLQNADDLQEMHSNMAEYFLGVWAGGIKKPFYNEPQYFENCIRKETRSILDENKHYNEQTSFDRQPPEQPWAFQCNPLEPDIF-------FVNHRKMTELLHHLTRSGMMEELMTGITMNFSWLYTMIKIGQFERALSDIAVAYNYSQQKELKFLASTLQSIKHKILKNPGSLSAELQQILLPVVSSLPKFRNLLVQCDKDGPKYCSIVPLHSSMDVTYSP 957

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Xenopus
Match: ppp1r3c.1 (protein phosphatase 1, regulatory (inhibitor) subunit 3C, gene 1 [Source:Xenbase;Acc:XB-GENE-969181])

HSP 1 Score: 101.293 bits (251), Expect = 1.286e-20
Identity = 125/571 (21.89%), Postives = 248/571 (43.43%), Query Frame = 1

Query: 1165 GYEDIVYAMLDYLTDDDTNV--PIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTS--NCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEV-GSQSLVTDLIPKFLPKNLKLIVSS-----------TDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDD--KNSHLKDFHQILAGYFNGAWVDQT-ISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYP-NLRFLIENCDKVAP-----KHNAFVPIYPSNKLPGSPLASTIN 2796
            G +D++  ++ Y+ +  + V  P+I++G   SGK+ +  +  FE      + S    +    TS  +  I ++  SI  Q+  I L      + + N   I N   R    +L +  ++  +  ++     ++ S   G+  L    +PK  P N+ ++VS+            DS    + Y   + V   +  + +  I+  + + G+ LT +Q E  L ++ K    +L   +  D     +      E +   +  E  +L      +  GK L+SH L YI  S  GL++ E+ ++L+LD +V+ ++Y   +        +++FP   W  ++ +L   LV+   DG  ++ L     +E   D    N+   + H  LA YF G W   T       L N  ++ +    SQ ++   +     N RK  +L  HL+     DEL   ++ + D++ +K  +  +  ++ DF+++      +EI+LL +++  S L + ++ D +   +  ++L  + ++  + R + E C +         H  F+P     + PG PL +T+ 
Sbjct:  306 GRQDLLQKIMSYIQERHSQVYPPLIIHGVSGSGKTALMCKA-FEMLKQTNNGSSLMVLRLLGTSPQSSEIHDVLKSICYQL-CIALELQPPSSQITN---IYNETVRFFHQLLTTVSERKVENLVLFFDSLDQLSPSEGAHRL--HWLPKECPANVCIVVSTLPEEGGILKTLKDSVTDPECY---IEVKPLSAEQGSQMIEMLMASAGRRLTNDQQEIVLGSFRKCGQPLLL-KLAFDEAKRWSSYTPITELMIATSTKEAVSLLYQCLEQLHGKLLVSHALGYIVASRSGLSEAELKDILSLDDEVLADIYQYWAPP---SNDLIRFPTLPWTRLRNDLEGYLVERQADGSTVLGLYHRQFIEVARDTYLTNTEKSNRHGTLADYFMGKWSMGTKRPILLPLINKSLNADRKVASQPLWFSDN---MPNRRKMSELPYHLLNAGCIDELQGEILGNMDWISSKIVSCGIQSVIKDFEMSVKLISSREIMLLRDTL--STLCLPSNTDPVI--VFTEMLARMHFFQLSYRLIDELCQQCTGWLHQYPHPTFIPTCGFFQPPGGPLQTTVT 855

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000003639.1 (uncharacterized LOC101730828 [Source:NCBI gene;Acc:101730828])

HSP 1 Score: 63.5438 bits (153), Expect = 3.655e-9
Identity = 131/551 (23.77%), Postives = 227/551 (41.20%), Query Frame = 1

Query: 1165 GYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFV--TSNCTIAEIFL-SIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGI------LLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIV-----SSTDSFDTRKPYFL--NV-LVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFI-YNSMEEIPCQ-TLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEV--YINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLA----TTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGK---EIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDK-VAPKH 2730
            G E  +  + D +T  +  + ++++G   SGKS + A+        +  D     +TRF+  T       + L S+  QI+ I                I  +   D++G+      LL F  +  +  ++ +   ++ S V   SL    IP+ LP+++  IV     S+  SF T +   +  NV  +P     E    I+  +    + LT  Q +             L   V+  Y  +  +  Y+S  +   Q  L + Y+  L R  K  G+ ++     YI  S  G+T +E++++L+LD  VM EV  Y N + S+        FP +LW+ ++ ++   LV+   D   +++ A      V +   +  K   L   H   A Y+      ++ S H    +PE      P    M+        +N RK   +  HL+  + +  LI   +F+++YL +K  A  V  L +D + A N  +   ++ LL E++  S  V+  D   LA +L  +L             IE  DK VAP H
Sbjct:    2 GRESFLQELQDCITSANKQL-VVVHGESGSGKSSIIAKIATLASQWIGRD--IRVVTRFIGRTGESRNPRMLLYSLCFQIAEIY--------------NITMDFSEDLKGLINEFSTLLEFANKC-RPLMVAVDGIDELS-VHEDSL--SWIPRVLPRHVYFIVCASTESACSSFRTLQKLTMQQNVHQIPPLDSEEIRNMIEVWMERDNRRLTGRQKKVLFDACAACP---LPLYVVSSYMESCLWTSYSSESDSYLQPNLHKLYSAVLGRLEKSHGEQVMKMVASYISLSKNGVTLEELLDLLSLDLGVMQEVKQYQNITVSV--------FPEALWIKLQNDIGTHLVEQRTDNTYVINWAHALFRVVCINRYLKSKELQL-SVHSAFANYYL-----ESKSRH---NHPEKVSLMMPL---MWTGTHRKPVFNLRKILGISHHLIHSNQFPRLITECLFNYEYLLHKVWATSVVGLQEDIKAAINPERPAPDLNLLSEALQLSTKVLLRDPTQLASQLKGRL-----------HQIEMLDKPVAPGH 497

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000022477.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460486.1:142089:157740:1 gene:ENSXETG00000010819.1 transcript:ENSXETT00000022477.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 1.505e-6
Identity = 114/549 (20.77%), Postives = 213/549 (38.80%), Query Frame = 1

Query: 1195 DYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTS---NCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDG----------ILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYK----RFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSH---LKDFHQILAGYFNGAWV------------------------DQTISFHF-DLKNPEMS--YNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLDSLAGELIMQ--LLPYVSYYPNL 2688
            DY+    +  P++++G    GK+++ A    +  S L    +   + RF+        ++ +   +  Q+S I  R     + L +  E+       ++ I LS +Q      I+I+ D +         +  D +P  +PK  K+IVS             NV+  +        F+  ++    +   +      L  Y K T G            T+ + V   +     + S +++  QTLGE       R +     ++G+ ++S  L YI  S  G+   E++++L  D  V+ + +      L   ++I + P  +   I  +L   L D +  G  LV     +  + ++    S    +++ H  +  +F+G W                         + T + H+ D + P     YN  P  Q+     +GNV    RK  +L  HL      ++L   V   F Y     +A ++  LL+  + A    G +E+  L + +   + +++   DSL  E+I Q  +LP V  YP L
Sbjct:  346 DYIVHGKSPKPMVVFGRSGCGKTVLLASCAKKVHSWL-ETCDPILVVRFICPFREPLHLSRLLGGLCYQLSDIYQR--VIPSHLDDVAELRQCF---VDLISLSSKQ---APLILIIDDVDH--------VPIDWLPSPIPKFTKIIVSVKHQ--------QNVISDQVKSQNKGQFLFLEIKPQRRECNDNLKHCLLGCYRKITSGQQMYVNRSLETNTSPLQVHLLFKLVAEWKSHQDVDNQTLGEDTYEAAERLFHKLEIKYGREIVSRTLSYITLSQSGIGVTELVDLLTADDLVLEKFH-----ELFGTENIPRIPDWIVTGILLDLQGCLADRMSAGCKLVYWNNRMYQQVIMTRYLSSPETVQELHTAMYYFFSGRWTCGKFISKAVQKFKSLLPNRRLANNNHTPNRHYLDYQPPSQPWFYNVLPVCQRAV---TGNV----RKALELPFHLKECGKLEKLYNEVFMAFPYYKVLVQAGQLHLLLNSIEDAAGIMGKQELYFLYDMLKEVSCLLKEKPDSL--EMIFQSKMLPLVLTYPPL 855

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Mouse
Match: Nwd2 (NACHT and WD repeat domain containing 2 [Source:MGI Symbol;Acc:MGI:1920464])

HSP 1 Score: 155.221 bits (391), Expect = 4.271e-37
Identity = 229/1000 (22.90%), Postives = 416/1000 (41.60%), Query Frame = 1

Query:   40 TSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQE--WKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSP-VIFNREIIDIKNFIVISNQKK------DDKR----KSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKF---GCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHD----SECHFITRFV-TSNCTI--AEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPR---DIEGILLSFQQQSN--KKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDG----------ILTASVIVDYFYNQNFIYNSMEEIP----CQTLGE-----FYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--------------------------VDQTISF----HFDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGG--KEIVLLE---ESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            T+LP  +  +P    +  F+ ++ ED   ER+ L   ++PKL+E C + +G+E ++ID+  G++     +   Q++  + L +        C + LLG+KYGN+  P  +    F+++L+     K    +E   LE +Y  D N V P    +  +   P   K         +QE  W++    +  +F+   K+    G +      +   +  E  F   + K   +     V + R+I +I+ F+ I    K       D R      A EKLI +       +V + +L+      +      Y        I      G+ +  ++  ID  +A +             + N D     L  YD I         +A F    C   +I++  +        N P+++YG P +GK+++ A    +    L  D    S+   I RF+ T++ +I    + LS+  Q++              N + +  + P+   D+  + ++   +S+  +  +IIL   E+ SE   ++     +P  LP+ +++I+S+  +    K   L  L     + +  I +   +    K+ ++    + L    K T G            T  + V+  + +   + S +++     C T+ E     F++L      K+ G+ L+S  L YI  +  GL++ E+ +VL LD  VMNE+  N   S     + ++ P      +K+ L+  L++  +K+  LLV  +    +  + L   ++S+L++ H ILA YF G W                          +++   F     FD + P+  +   C P    ++       F N+RK  +L+ HL      D+L+  +I +F +LY   K  +  ++L D +LA N    KE+  L     SI N  +       SL+ EL  +LLP VS  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:   28 TALP--SHLVPAGRSVRVFISANPEDTGAERQALRETVYPKLREFCRENYGLEFQVIDLYWGIEEDEWDSPELQKMRMKLLEECLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAVEAK----LETKLLEDWYCRDENSV-PAAYYLRPRLEVPRSNKNSTQPSASSEQERPWQEISDEIKTIFKAAVKLLHEQGKMKQSQAKRYLFSAIEDEFDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTDPRIVRDPEAQEKLIKLRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYI-----EGLGKQFYEDMIDIIQATV-------------QQNFDTETDTL--YDEILQHSSLCKTYASFYEYKCESLNILHKYILPSKTGHIN-PLVVYGGPCTGKTLLLAEVAKKAYGWLHEDTGPDSDPVVIVRFLGTTDMSIDLRTLLLSVCEQLAV-------------NYRCLVQSFPKKIHDLRDLFINLLNESSLQRPLVIILDALEQLSE-ADEARKLWWLPAHLPRFVRIILSTLPN----KHGILQKLRCLIHEEDNYIEL---IPRDRKMCSQVLKHQLLRVKRKVTSGQQIYVNNAFSKCTLPMFVNLTFREVRHWRSHKDVDESSLCVTVHESIEQLFWSLE-----KKCGQKLVSRALGYITMAKMGLSEMELEDVLALDNSVMNELNENTRPS-----NPLRVPYLYIARLKEGLNGYLIERHVKNVTLLVWANRHLQLIAQKLYLQEDSNLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIF-------FVNHRKMSELLYHLTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLADIELAYNYSQEKELKFLASTLRSIRNKVIAFPG---SLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 958

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 87.8113 bits (216), Expect = 1.307e-16
Identity = 85/357 (23.81%), Postives = 165/357 (46.22%), Query Frame = 1

Query: 1939 GKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV-----DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW---VDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLA--RNGGKEIVLLEESINNSALVIE-NDLDS--LAGELIMQLLPYVSYYPNLRFLIENCDKV-----APKHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            G  L++H L YI  S  GL++ E+ +VL+LD +V+  VY + +      + +++FP  LW+ ++++L   LV    DG +L+      L+  + V  L   + +     H +LA +F+GAW   + + I+     K   +     P  Q ++     +   N RK  +L  HL+     +EL + V+ +  ++  +  +  +  LLDDF +        E+ L+ E+I      +E   L+   L  EL+ +LL + + +P +  + + C +      A  +   VP+    + PG PL +T+  C + I ++       S+ ++LL+    D     +D+    + +  +  + EV
Sbjct:  616 GALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPP---SKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERA---KRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAP--QPLWFS---STVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAM--IGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAI-----AWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEV 954

HSP 2 Score: 74.7146 bits (182), Expect = 1.295e-12
Identity = 85/417 (20.38%), Postives = 162/417 (38.85%), Query Frame = 1

Query:   85 INFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDD--TNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
            +  F+ S+  D + ER+ L    +P++Q  C    G+  +++D++ G+ +   T     ++  E L +   C K +  P F  LLG +YG    P RI  K ++ L   L +  +        + +++  D N + P  +L            Q   S+++   E     S+L    Q   ++    G +  E       +  E      +  S        +F R++ D+   I+      DD     +++L+D     NA        QS+L        +    +     + W RD        H  Y+ Q      A+    V E+ +++ L         Y  I +   Q  +  K  CG+++++  +   L  D+  T+ P++L+GPP  GK+ +  +   +    L H +
Sbjct:   31 VVIFISSTISDMDTEREALQCTAYPEVQSFC-QRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELER---CQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDL----ELVTRHFQRDDNTIPPTYVL------------QPSGSLVVPGPEEATLTSVLRGGAQEAWRL----GLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHIL------DDCSLKMVDRLVDGCLDTNA--------QSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELA-RQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKT 408

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 87.8113 bits (216), Expect = 1.341e-16
Identity = 83/341 (24.34%), Postives = 159/341 (46.63%), Query Frame = 1

Query: 1939 GKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV-----DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW---VDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLA--RNGGKEIVLLEESINNSALVIE-NDLDS--LAGELIMQLLPYVSYYPNLRFLIENCDKV-----APKHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDL 2904
            G  L++H L YI  S  GL++ E+ +VL+LD +V+  VY + +      + +++FP  LW+ ++++L   LV    DG +L+      L+  + V  L   + +     H +LA +F+GAW   + + I+     K   +     P  Q ++     +   N RK  +L  HL+     +EL + V+ +  ++  +  +  +  LLDDF +        E+ L+ E+I      +E   L+   L  EL+ +LL + + +P +  + + C +      A  +   VP+    + PG PL +T+  C + I ++       S+ ++LL+    D     +D+
Sbjct:  575 GALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPP---SKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERA---KRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAP--QPLWFS---STVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAM--IGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAI-----AWSLEEKLLVVGTQDGAMVVWDV 897

HSP 2 Score: 67.3958 bits (163), Expect = 1.969e-10
Identity = 82/406 (20.20%), Postives = 156/406 (38.42%), Query Frame = 1

Query:  118 FEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDD--TNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
             + ER+ L    +P++Q  C    G+  +++D++ G+ +   T     ++  E L +   C K +  P F  LLG +YG    P RI  K ++ L   L +  +        + +++  D N + P  +L            Q   S+++   E     S+L    Q   ++    G +  E       +  E      +  S        +F R++ D+   I+      DD     +++L+D     NA        QS+L        +    +     + W RD        H  Y+ Q      A+    V E+ +++ L         Y  I +   Q  +  K  CG+++++  +   L  D+  T+ P++L+GPP  GK+ +  +   +    L H +
Sbjct:    1 MDTEREALQCTAYPEVQSFC-QRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELER---CQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDL----ELVTRHFQRDDNTIPPTYVL------------QPSGSLVVPGPEEATLTSVLRGGAQEAWRL----GLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHIL------DDCSLKMVDRLVDGCLDTNA--------QSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELA-RQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKT 367

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 87.8113 bits (216), Expect = 1.398e-16
Identity = 85/357 (23.81%), Postives = 165/357 (46.22%), Query Frame = 1

Query: 1939 GKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV-----DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW---VDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLA--RNGGKEIVLLEESINNSALVIE-NDLDS--LAGELIMQLLPYVSYYPNLRFLIENCDKV-----APKHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            G  L++H L YI  S  GL++ E+ +VL+LD +V+  VY + +      + +++FP  LW+ ++++L   LV    DG +L+      L+  + V  L   + +     H +LA +F+GAW   + + I+     K   +     P  Q ++     +   N RK  +L  HL+     +EL + V+ +  ++  +  +  +  LLDDF +        E+ L+ E+I      +E   L+   L  EL+ +LL + + +P +  + + C +      A  +   VP+    + PG PL +T+  C + I ++       S+ ++LL+    D     +D+    + +  +  + EV
Sbjct:  575 GALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPP---SKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERA---KRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAP--QPLWFS---STVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAM--IGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAI-----AWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEV 913

HSP 2 Score: 67.3958 bits (163), Expect = 2.184e-10
Identity = 82/406 (20.20%), Postives = 156/406 (38.42%), Query Frame = 1

Query:  118 FEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDD--TNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
             + ER+ L    +P++Q  C    G+  +++D++ G+ +   T     ++  E L +   C K +  P F  LLG +YG    P RI  K ++ L   L +  +        + +++  D N + P  +L            Q   S+++   E     S+L    Q   ++    G +  E       +  E      +  S        +F R++ D+   I+      DD     +++L+D     NA        QS+L        +    +     + W RD        H  Y+ Q      A+    V E+ +++ L         Y  I +   Q  +  K  CG+++++  +   L  D+  T+ P++L+GPP  GK+ +  +   +    L H +
Sbjct:    1 MDTEREALQCTAYPEVQSFC-QRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELER---CQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDL----ELVTRHFQRDDNTIPPTYVL------------QPSGSLVVPGPEEATLTSVLRGGAQEAWRL----GLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHIL------DDCSLKMVDRLVDGCLDTNA--------QSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELA-RQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKT 367

[Close]

BLAST of AAA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6P5U7|NWD2_MOUSE (NACHT and WD repeat domain-containing protein 2 OS=Mus musculus OX=10090 GN=Nwd2 PE=1 SV=2)

HSP 1 Score: 155.221 bits (391), Expect = 2.988e-36
Identity = 229/1000 (22.90%), Postives = 416/1000 (41.60%), Query Frame = 1

Query:   40 TSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQE--WKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSP-VIFNREIIDIKNFIVISNQKK------DDKR----KSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKF---GCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHD----SECHFITRFV-TSNCTI--AEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPR---DIEGILLSFQQQSN--KKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDG----------ILTASVIVDYFYNQNFIYNSMEEIP----CQTLGE-----FYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--------------------------VDQTISF----HFDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGG--KEIVLLE---ESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            T+LP  +  +P    +  F+ ++ ED   ER+ L   ++PKL+E C + +G+E ++ID+  G++     +   Q++  + L +        C + LLG+KYGN+  P  +    F+++L+     K    +E   LE +Y  D N V P    +  +   P   K         +QE  W++    +  +F+   K+    G +      +   +  E  F   + K   +     V + R+I +I+ F+ I    K       D R      A EKLI +       +V + +L+      +      Y        I      G+ +  ++  ID  +A +             + N D     L  YD I         +A F    C   +I++  +        N P+++YG P +GK+++ A    +    L  D    S+   I RF+ T++ +I    + LS+  Q++              N + +  + P+   D+  + ++   +S+  +  +IIL   E+ SE   ++     +P  LP+ +++I+S+  +    K   L  L     + +  I +   +    K+ ++    + L    K T G            T  + V+  + +   + S +++     C T+ E     F++L      K+ G+ L+S  L YI  +  GL++ E+ +VL LD  VMNE+  N   S     + ++ P      +K+ L+  L++  +K+  LLV  +    +  + L   ++S+L++ H ILA YF G W                          +++   F     FD + P+  +   C P    ++       F N+RK  +L+ HL      D+L+  +I +F +LY   K  +  ++L D +LA N    KE+  L     SI N  +       SL+ EL  +LLP VS  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:   28 TALP--SHLVPAGRSVRVFISANPEDTGAERQALRETVYPKLREFCRENYGLEFQVIDLYWGIEEDEWDSPELQKMRMKLLEECLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAVEAK----LETKLLEDWYCRDENSV-PAAYYLRPRLEVPRSNKNSTQPSASSEQERPWQEISDEIKTIFKAAVKLLHEQGKMKQSQAKRYLFSAIEDEFDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTDPRIVRDPEAQEKLIKLRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYI-----EGLGKQFYEDMIDIIQATV-------------QQNFDTETDTL--YDEILQHSSLCKTYASFYEYKCESLNILHKYILPSKTGHIN-PLVVYGGPCTGKTLLLAEVAKKAYGWLHEDTGPDSDPVVIVRFLGTTDMSIDLRTLLLSVCEQLAV-------------NYRCLVQSFPKKIHDLRDLFINLLNESSLQRPLVIILDALEQLSE-ADEARKLWWLPAHLPRFVRIILSTLPN----KHGILQKLRCLIHEEDNYIEL---IPRDRKMCSQVLKHQLLRVKRKVTSGQQIYVNNAFSKCTLPMFVNLTFREVRHWRSHKDVDESSLCVTVHESIEQLFWSLE-----KKCGQKLVSRALGYITMAKMGLSEMELEDVLALDNSVMNELNENTRPS-----NPLRVPYLYIARLKEGLNGYLIERHVKNVTLLVWANRHLQLIAQKLYLQEDSNLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIF-------FVNHRKMSELLYHLTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLADIELAYNYSQEKELKFLASTLRSIRNKVIAFPG---SLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 958

[Close]

BLAST of AAA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9ULI1|NWD2_HUMAN (NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NWD2 PE=2 SV=3)

HSP 1 Score: 146.362 bits (368), Expect = 1.228e-33
Identity = 215/995 (21.61%), Postives = 411/995 (41.31%), Query Frame = 1

Query:   40 TSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCV--------EPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSP-VIFNREIIDIKNFI----------VISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKF---GCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHD----SECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSF-----QQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEF--------NIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWY----KRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--------------------------VDQTISF----HFDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDL----DSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            T+LP  +  +P    +  F+ ++ ED   ER+ L   ++PKL+E C + +G+E ++ID+  G++     +   Q+   + L          C + LLG+KYGN+  P  +    F+++L+     K    +E   LE++Y  D N V        + EM+  +  A+ P    ++       ++ W++    +  +F+   K+    G +      +   +  E  F   + K   +     V + R+I +I+ F+          +   + +  +   A EKLI +       +V + +L+      +      Y        I      G+ +  ++  ID  +A I             + N D     L  YD I         +A F    C   +IV+  +        N P+I+YG P +GK+++ A    +    L  D    S+   I RF+ +   ++    ++ L +          E +  N + +  + P+ I  +   F     +    +  +II    E+ SE    +     +P  LP+ +++++S+  +          ++  E    E         +  ++ QL    + +T  Q + +++N L       T  + V+  + +   + S +++   +L      ++ + +    K+ G+ L+S  L YI  +  GL++ E+ +VL LD  VM+E+  N   S     + ++ P      +K+ LS  L++  +K+  LLV  +    +  + L    ++ L++ H ILA YF G W                          +++   F     FD + P+  +   C P    ++       F N+RK  +L+ HL      D+L+  +I +F +LY   K  +  ++L D +LA N  +E  L  + + N+   I+N +     SL+ EL  +LLP VS  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:   28 TALP--SHLVPAGRSVRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAIEAK----LETKLLEEWYCRDENSVPAAYYLRPKSEMLRSNRNAMQPSTNAEN-------EKTWQEISDEIKKIFKAAVKLLHEKGKMKHSQAKRYLFSAIEDEFDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIKLRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYI-----EGLGKQFYEDMIDIIQATI-------------QQNFDTETDTL--YDEILQHSSLCKTYASFYEYKCESLNIVHNYILPSKAGHIN-PLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTT-DMSSDLRTLLLSVC---------EQLAVNYRCLVQSYPKKIHDLCDLFINLLNESSLQRPLVIIFDALEQLSE-NDDARKLWWLPAHLPRFVRIVLSTLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQ-QIYVNNALSKC----TLPMFVNLTFREVRHWRSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELEDVLALDNSVMSELKENTRPS-----NPLRVPYLYIARLKEGLSGYLIERHVKNVTLLVWANRHLQLIAQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIF-------FVNHRKMSELLYHLTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLSDIELAYNYSQEKEL--KFLANTLRSIKNKVTAFPGSLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 958

[Close]

BLAST of AAA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q149M9|NWD1_HUMAN (NACHT domain- and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=NWD1 PE=1 SV=3)

HSP 1 Score: 90.5077 bits (223), Expect = 1.394e-16
Identity = 89/376 (23.67%), Postives = 169/376 (44.95%), Query Frame = 1

Query: 1876 IPCQTLGEFYALNL-NRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDD--KNSHLKDFHQILAGYFNGAWVDQT---ISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIE---NDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAP-----KHNAFVPIYPSNKLPGSPLASTIN-CPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEV 2952
            +P  T  E     L  R  +  G+ L++H L YI  S  GL++ E+ +VL+LD +V+ +VY + +      + +++FP  LW+ ++++L   L     DG+ L+ +A    VE + +     S     H +LA +F+G W   T   I+     K   +     P  Q ++     +   N RK ++L  HL+     +EL + V+    ++  +  +  + +LLDDF L        E+ L+ E++      +E    +   L  EL+ +L  + + +P L  + + C +         H   VP+    + PG PL +T++ C + I ++        + ++LL+    D     +D+    + +     +GEV
Sbjct:  553 VPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPP---SKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAP--QPLWFS---HTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPAL--VGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAM-----AWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEV 913

HSP 2 Score: 67.3958 bits (163), Expect = 1.576e-9
Identity = 82/398 (20.60%), Postives = 161/398 (40.45%), Query Frame = 1

Query:  148 RIFPKLQEQCF-DEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKC-YDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDT--NVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
            R  P L+ Q F    G+  +++D++ G+ +   T     ++  E +++   C K +  P F  L+G +YG    P  IP++I +   E L++H      +   + +Y+  D N   P  +L            Q   +   C+ E     S+L +  Q   ++    G +  E       +  E     ++  S D +    +F REI D+   I+      +D     +++L        AD  ++ D Q++L    +   +++       R+ W RD        H  Y+ +       +    V  R ++  LD +   L   Y  I +   Q ++  +  CG ++++  +   L  DD+  + P++L+GPP  GK+ +  +   +    L H +
Sbjct:    8 RALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDR---CWKTSIGPAFVALIGDQYG----PCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVL------------QAPGTGEACEPEEATLTSVLRSGAQEARRL----GLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHIL------EDCALRMVDRL--------ADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRE--LDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT 366

[Close]

BLAST of AAA domain-containing protein vs. UniProt/SwissProt
Match: sp|A6H603|NWD1_MOUSE (NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2)

HSP 1 Score: 87.8113 bits (216), Expect = 9.377e-16
Identity = 83/341 (24.34%), Postives = 159/341 (46.63%), Query Frame = 1

Query: 1939 GKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV-----DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW---VDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLA--RNGGKEIVLLEESINNSALVIE-NDLDS--LAGELIMQLLPYVSYYPNLRFLIENCDKV-----APKHNAFVPIYPSNKLPGSPLASTI-NCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDL 2904
            G  L++H L YI  S  GL++ E+ +VL+LD +V+  VY + +      + +++FP  LW+ ++++L   LV    DG +L+      L+  + V  L   + +     H +LA +F+GAW   + + I+     K   +     P  Q ++     +   N RK  +L  HL+     +EL + V+ +  ++  +  +  +  LLDDF +        E+ L+ E+I      +E   L+   L  EL+ +LL + + +P +  + + C +      A  +   VP+    + PG PL +T+  C + I ++       S+ ++LL+    D     +D+
Sbjct:  575 GALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPP---SKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERA---KRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAP--QPLWFS---STVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAM--IGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAI-----AWSLEEKLLVVGTQDGAMVVWDV 897

HSP 2 Score: 67.3958 bits (163), Expect = 1.377e-9
Identity = 82/406 (20.20%), Postives = 156/406 (38.42%), Query Frame = 1

Query:  118 FEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYN-CPIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILW-RDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDD--TNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDS 1317
             + ER+ L    +P++Q  C    G+  +++D++ G+ +   T     ++  E L +   C K +  P F  LLG +YG    P RI  K ++ L   L +  +        + +++  D N + P  +L            Q   S+++   E     S+L    Q   ++    G +  E       +  E      +  S        +F R++ D+   I+      DD     +++L+D     NA        QS+L        +    +     + W RD        H  Y+ Q      A+    V E+ +++ L         Y  I +   Q  +  K  CG+++++  +   L  D+  T+ P++L+GPP  GK+ +  +   +    L H +
Sbjct:    1 MDTEREALQCTAYPEVQSFC-QRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELER---CQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDL----ELVTRHFQRDDNTIPPTYVL------------QPSGSLVVPGPEEATLTSVLRGGAQEAWRL----GLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHIL------DDCSLKMVDRLVDGCLDTNA--------QSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELA-RQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKT 367

[Close]

BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A267EA39 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033440g1 PE=4 SV=1)

HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0
Identity = 429/1479 (29.01%), Postives = 723/1479 (48.88%), Query Frame = 1

Query:   31 LIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEP----EMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNAD-LVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQF-EAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTD--DDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQ---FETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC-----SEVGSQSLVTDLIPKFLPKNLKLIVSSTDS-----FDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLL-----VDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--VDQTISFHFDLKNPEMSYNCCPKSQKMYA-------------KKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHI--ADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKIQIG--GSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTV--KNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFYCITNHSKSIDAPNFIVTQILCDLGVE 4326
            L    LP ++        I F + S+F DFE ER++L N  +P+L E   + +G++ + +DIKLGL+        Y  +F++   K       + P+ LLGQK+G  L P R+P++ F+L+  TL+ H+     + + L+ +Y  D N   P    E +L+      PD+  +D  +      EWK T  +L+NLF+    ICL  GT+D +   +I   E +A  S  +  S  ++F PV+F R+IID+KN++   N+ K D          DV   +  D  +I++ L  +L Q  N     Y + + +F +LWR   G+ +  H+ Y+  F EAFI A     V  R     +   +  ++ +D    +       A F    E  + A+++Y  D     N   +L G  N+GK    A+   E Q  L        I R V     ++++  S+F QI      +           NS E     PR+++ ++           ++++   E+        +  QSLV    P+  P N+KL++++ D           P+   + +   T   +  F +  L    + LT EQ  R+    L   + +  AS++ D         +  +      L +      +R   +FG+  +SH   Y+  S GGLTD EV ++L+LD  V++E+ +        +  + +FP S+WLL+KQE+ +++ +   DGY +      D+ + V+   L  D     K  H  +A YF G W  V + +S      +   +    P  + MY+              + G+ FYN RKFRQL RHL   D   EL   V+F +D+LY K+ AL + E L DFQL  +   E+ L+EE+I  +  ++ ++L++LA EL   L+ Y   Y N++ L+   D    +HN FVP Y   KLPGS L ST+ CP  ++S+    +  S    L +KLK+D   Y YDL  G +      SSGE++   +    ++++   R  +KVH    G  +G I+P+NW+   PFEE++ +RIT + + +  +A I+ + +S + + +L T +PI  F P  R  +  +TPDE  +FT++ E+++   +      S V+L  +P +++F  + S +AFI+C+ ++ VV+L +++ G +   +KI FEN L  +D + ++  S+     LL+ +  +V++Y++ ++ ++ HI RP ++P  FK+PN        + F+ A     DRV+I ++FRDV+V  V   + +  LHAP  GI++ + +      ++G +E S+   E+ +W        F      D LT  ++ ++       A+A C  SDEMGV+++ TG L DLYSH  VV++C +SSCG +A+ +V  +N +  NI+WSL  R+I+ EFG+      ++P +  S  Y +     +   P  I    L D  V 
Sbjct:    8 LCSGRLPLSSLPTVSPRSITFCIISAFSDFEKEREVLRNEAYPRLYEYFRNTYGLQFRGVDIKLGLEKVNYDELDYWDLFHDIKRKFAFASHDSVPVILLGQKFGLPLLPRRLPSRAFELIRATLRAHRNPLTAQYHILDSWYRRDENAECPDGDTEHVLLPASRQLPDIVGEDPEAKASALAEWKFTARLLANLFKIGVGICLREGTMDDQTAFEILTFELDAGISHLLSHSDLTQFRPVVFERDIIDLKNYL---NEPKADL-------YTDVELDEENDRFLIDKSLADLL-QELNDRLTTYASVDRQFSVLWRFPDGIDKRLHEEYLGDFCEAFIEAAKT-AVESRLAGKQMHADSEVVRVFDDAWTSLEHCRLLAPFSLRQEATIEAVVEYCVDFSARQNYTYLLLGGQNTGKMPAIAQAFIEIQQRLCESPVGVLIPRVVMFERRLSDLTASLFNQIRTCCRLDTGGVVATGAGANSAEQTAPPPRNLQELVDRLSGAG--PVVLLIAGAERLVDDAGDRLPPQSLVP--APRGPPSNVKLVLTALDEAGGSVLSLAGPHLRVLHIGPQTADAYREFARHYLAERSRRLTAEQ-WRWAEQRLAGLESMFHASLLCDRLARLASGDDPADLPASSGLADLLDAEFDRLEAKFGRIAVSHAFAYVSLSGGGLTDIEVKDLLSLDDAVLDEMLVP------IEDGVRQFPSSVWLLMKQEVRLLIHEASFDGYFVNYWANGDVESAVAARYLSSDDLR--KSLHFTMADYFLGTWHGVSKPVSTVSSADDVSSADRLMPTQKLMYSIEGETGGSVTSGGGQQGS-FYNERKFRQLPRHLFLSDRVPELNNLVLFSYDWLYYKSAALGLEETLRDFQLVPSN-TEVSLVEETIRKAFDILGDNLNNLAAELSGSLVLYSHEYKNIKNLVRQADVRGCQHNIFVPCYSYAKLPGSALQSTVECPSNLQSM----HLSSETATLYVKLKDDVSLYKYDLERGTMLGEARTSSGELHLSADERYAVMVDDRKRSHLKVHLCSDGSFVGHILPLNWIDTMPFEEKSMFRITKVRVARRLVACIVASRMSSVIIADLATCQPIHVFKPDRRAALCDITPDERFIFTNNGEQVLVFEIGNGVQTSVVDLLAVPKRLMFTRDGS-RAFIMCEGEQKVVILYMDAKGAIEMSFKIMFENSLG-DDRLQDMRVSQ-AEQLLLVRAEKNVLVYEFGRDAIVAHIRRPPEIPAEFKMPN---ANYERINFSEADFAFGDRVVITSIFRDVLVWEVEQGRPLVMLHAPT-GILTRLLVDQTRSLVVGFIEHSR---EIHLWSLQGA---FTDGTAVDSLTAPIRAVRSARRRPRAVACCDNSDEMGVVDLDTGYLTDLYSHEGVVVDCAISSCGDYAVASVVQRNPNTTNIVWSLSERRILAEFGNVPG--HLLPCRHSSDVYIVDQAEVAFKQPFGITRLALGDGAVR 1440

[Close]

BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A267FKI0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033440g3 PE=4 SV=1)

HSP 1 Score: 626.706 bits (1615), Expect = 0.000e+0
Identity = 427/1479 (28.87%), Postives = 724/1479 (48.95%), Query Frame = 1

Query:   31 LIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEP----EMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNAD-LVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQF-EAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTD--DDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQ---FETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC-----SEVGSQSLVTDLIPKFLPKNLKLIVSSTDS-----FDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLL-----VDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--VDQTISFHFDLKNPEMSYNCCPKSQKMYA-------------KKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHI--ADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKIQIG--GSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTV--KNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFYCITNHSKSIDAPNFIVTQILCDLGVE 4326
            L    LP ++        I F + S+F DFE ER++L N  +P+L E   + +G++ + +DIKLGL+        Y  +F++   K       + P+ LLGQK+G  L P R+P++ F+L+  TL+ H+     + + L+ +Y  D N   P    E +L+      PD+  +D  +      EWK T  +L+NLF+    ICL  GT+D +   +I   E +A  S  +  S  ++F P++F R+IID+KN++   N+ K D          DV   +  D  +I++ L  +L Q  N     Y + + +F +LWR   G+ +  H+ Y+  F EAFI A     V  R     +   +  ++ +D    +       A F    E  + A+++Y  D     N   +L G  N+GK    A+   E Q  L        I R V     ++++  S+F QI      +           NS E     PR+++ ++           ++++   E+        +  QSLV    P+  P N+KL++++ D           P+   + +   T   +  F +  L    + LT EQ  R+    L   + +  AS++ D         +  +      L +      +R   +FG+  +SH   Y+  S GGLTD EV ++L+LD  V++E+ +        +  + +FP S+WLL+KQE+ +++ +   DGY +      D+ + V+   L  D     K  H  +A YF G W  V + +S      +   +    P  + MY+              + G+ FYN RKFRQL RHL   D   EL   V+F +D+LY K+ AL + E L DFQL  +   E+ L+EE+I  +  ++ ++L++LA EL   L+ Y   Y N++ L+   D    +HN FVP Y   KLPGS L ST+ CP  ++S+    +  S    L +KLK+D   Y YDL  G +      SSGE++   +    ++++   R  +KVH    G  +G I+P+NW+   PFEE++ +RIT + +++  +A I+ + +S + + +L T +PI  F P  R  +  +TPDE  +FT++ E+++   +      S V+L  +P +++F  + S +AFI+C+ ++ VV+L +++ G +   +KI F+N L  +D + ++  S+     LL+ +  +V++Y++ ++ ++ HI RP ++P  FK+PN        + F+ A     DRV+I ++FRDV+V  V   + +  LHAP  GI++ + +      ++G +E S+   E+ +W        F      D LT  ++ ++       A+A C  SDEMGV+++ TG L DLYSH  VV++C +SSCG +A+ +V  +N +  NI+WSL  R+I+ EFG+      ++P +  S  Y +     +   P  I    L D  V 
Sbjct:    8 LCSGRLPLSSLPTVSPRSITFCIISAFSDFEKEREVLRNEAYPRLYEYFRNTYGLQFRGVDIKLGLEKVNYDELDYWDLFHDIKRKFAFASHDSVPVILLGQKFGLPLLPRRLPSRAFELIRATLRAHRNPLTAQYHILDSWYRRDENAECPDGDTEHVLLPASRQLPDIVGEDPEAKASALAEWKFTARLLANLFKIGVGICLREGTMDDQTAFEILTFELDAGISHLLSHSDLTQFRPIVFERDIIDLKNYL---NEPKADL-------YTDVELDEENDRFLIDKSLADLL-QELNDRLTTYASVDRQFSVLWRFPDGIDKRLHEEYLGDFCEAFIEAAKT-AVESRLAGKQMHADSEVVRVFDDAWTSLEHCRLLAPFSLRQEATIEAVVEYCVDFSARQNYTYLLLGGQNTGKMPAIAQAFIEIQQRLCESPVGVLIPRVVMFERRLSDLTASLFNQIRTCCRLDTGGVVATGAGANSAEQTAPPPRNLQELVDRLSGAG--PVVLLIAGAERLVDDAGDRLPPQSLVP--APRGPPSNVKLVLTALDEAGGSVLSLAGPHLRVLHIGPQTADAYREFARHYLAERSRRLTAEQ-WRWAEQRLAGLESMFHASLLCDRLARLASGDDPADLPASSGLADLLDAEFDRLEAKFGRIAVSHAFAYVSLSGGGLTDIEVKDLLSLDDAVLDEMLVP------IEDGVRQFPSSVWLLMKQEVRLLIHEASFDGYFVNYWANGDVESAVAARYLSSDDLR--KSLHFTMADYFLGTWHGVSKPVSTVSSADDVSSADRLMPTQKLMYSIEGETGGSVTSGGGQQGS-FYNERKFRQLPRHLFLSDRVPELNNLVLFSYDWLYYKSAALGLEETLRDFQLVPSN-TEVSLVEETIRKAFDILGDNLNNLAAELSGSLVLYSHEYKNIKNLVRQADVRGCQHNIFVPCYSYAKLPGSALQSTVECPSNLQSM----HLSSETATLYVKLKDDVSLYKYDLERGTMLGEARTSSGELHLSADERYAVMVDDRKRSHLKVHLCSDGSFVGHILPLNWIDTMPFEEKSMFRITKVRVSRRLVACIVASRMSSVIIADLATCQPIHVFKPDRRAALCDITPDERFIFTNNGEQVLVFEIGNGVQTSVVDLLAVPKRLMFTRDGS-RAFIMCEGEQKVVILYMDAKGAIEMSFKIMFDNSLG-DDRLQDMRVSQ-AEQLLLVRAEKNVLVYEFGRDAIVAHIRRPPEIPAEFKMPN---ANYERINFSEADFAFGDRVVITSIFRDVLVWEVEQGRPLVMLHAPT-GILTRLLVDQTRSLVVGFIEHSR---EIHLWSLQGA---FTDGTAVDSLTAPIRAVRSARRRPRAVACCDNSDEMGVVDLDTGYLTDLYSHEGVVVDCAISSCGDYAVASVVQRNPNTTNIVWSLSERRILAEFGNVPG--HLLPCRHSSDVYIVDQAEVAFKQPFGITRLALGDGAVR 1440

[Close]

BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A267G6I1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033440g2 PE=4 SV=1)

HSP 1 Score: 621.698 bits (1602), Expect = 0.000e+0
Identity = 427/1479 (28.87%), Postives = 720/1479 (48.68%), Query Frame = 1

Query:   31 LIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEP----EMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNAD-LVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQF-EAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTD--DDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQ---FETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC-----SEVGSQSLVTDLIPKFLPKNLKLIVSSTDS-----FDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLL-----VDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--VDQTISFHFDLKNPEMSYNCCPKSQKMYA-------------KKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHI--ADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKIQIG--GSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTV--KNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFYCITNHSKSIDAPNFIVTQILCDLGVE 4326
            L    LP ++        I F + S+F DFE ER++L N  +P+L E   + +G++ + +DIKLGL+        Y  +F++   K       + P+ LLGQK+G  L P R+P++ F L+  TL+ H+     +   L+ +Y  D N   P    E +L+      PD+  +D  +      EWK T  +L+NLF+    ICL  GT+D +   +I   E +A  S  +  S  ++F P++F R+IID+KN++   N+ K D          DV   +  D  +I++ L  +L Q  N     Y + + +F +LWR   G+ +  H+ Y+  F EAFI A     V  R     +   +  ++ +D    +       A F    E  + A+++Y  D     N   +L G  N+GK    A+   E Q  L        I R V     ++++  S+F QI      +           NS E     PR+++ ++           ++++   E+        +  QSLV    P+  P N+KL++++ D           P+   + +   +   +  F +  L    + LT EQ  R+    L   + +  AS++ D         +  +      L +      +R   +FG+  +SH   Y+  S GGLTD EV ++L+LD  V++E+ +        +  + +FP S+WLL+KQE+ +++ +   DGY +      D+ + V+   L  D     K  H  +A YF G W  V + +S      +   +    P  + MY+              + G+ FYN RKFRQL RHL   D   EL   V+F +D+LY K+ AL + E L DFQL  +   E+ L+EE+I  +  ++  +L++LA EL   L+ Y   Y N++ L+   D    +HN FVP Y   KLPGS L ST+ CP  ++S+    +  S    L +KLK+D   Y YDL  G +      SSGE++   +    ++++   R  +KVH    G  +G I+P+NW+   PFEE++ +RIT + + +  +A I+ + +S + + +L T +PI  F P  R  +  +TPDE  +FT++ E+++   +      S V+L  +P +++F  + S +AFI+C+ ++ VV+L +++ G +   +KI FEN L  +D + ++  S+     LL+ +  +V++Y++ ++ ++ HI RP ++P  FK+PN        + F+ A     DRV+I ++FRDV+V  V   + +  LHAP  GI++ + +      ++G +E S+   E+ +W        F      D LT  ++ ++       A+A C  SDEMGV+++ TG L DLYSH  VV++C +SSCG +A+ +V  +N +  NI+WSL  R+I+ EFG+      ++P +  S  Y +     +   P  I    L D  V 
Sbjct:    8 LCSGRLPLSSLPTVSPRSITFCIISAFSDFEKEREVLRNEAYPRLYEYFRNTYGLQFRGVDIKLGLEKVNYDELDYWDLFHDIKRKFAFASHDSVPVILLGQKFGLPLLPRRLPSRAFDLIRATLRAHRNPLTAQYYILDSWYRRDDNAECPDGDTEHVLLPASRQLPDIVGEDPEAKASALAEWKFTARLLANLFKIGVGICLREGTMDDQTAFEILTFELDAGISHLLSHSDLTQFRPIVFERDIIDLKNYL---NEPKADL-------YTDVELDEENDRYLIDKSLADLL-QELNDRLTTYASVDRQFSVLWRFPDGIDKRLHEEYLGDFCEAFIEAAKT-AVESRLAGKQMHADSEVVRVFDDAWTSLEHCRLLAPFSLRQEATIEAVVEYCVDFSARQNYTYLLLGGQNTGKMPAIAQAFIEIQQRLCESPVGVLIPRVVMFERRLSDLTASLFNQIRTCCRLDTGGVVATGAGANSTEQTAPPPRNLQELVDRLSGAG--PLVLLIAGAERLVDDAGDRLPPQSLVP--APRGPPSNVKLVLTALDEAGGSVLSLAGPHLRVLHIGPQSADAYREFARHYLAERSRRLTAEQ-WRWAEQRLAGLESMFHASLLCDRLARLASGDDPADLPANSGLADLLDAEFDRLEAKFGRIAVSHAFAYVSLSGGGLTDIEVKDLLSLDDAVLDEMLVP------IEDGVRQFPSSVWLLMKQEVRLLIHEASFDGYFVNYWANGDVESAVAARYLSSDDLR--KSLHFTMADYFLGTWHGVSKPVSTVSSADDVSSADRLMPTQKLMYSIEGETGGSVTSGGGQQGS-FYNERKFRQLPRHLYLSDRVPELNNLVLFSYDWLYYKSAALGLEETLRDFQLVPSN-TEVSLVEETIRKAFDILGENLNNLAAELSGSLVLYSHEYKNIKNLVRQADVRGCQHNIFVPCYSYAKLPGSALQSTVECPSNLQSM----HLSSETATLYVKLKDDVSLYKYDLERGTMLGEARTSSGELHLSADERYAVMVDNRKRSHLKVHLCSDGSFVGHILPLNWIDTMPFEEKSMFRITKVRVARRLVACIVASRMSSVIIADLATCQPIHVFKPDRRAALCDITPDERFIFTNNGEQVLVFEIGNGVQTSVVDLLAVPKRLMFTRDGS-RAFIMCEGEQKVVILYMDAKGAIEMSFKIMFENSLG-DDRLQDMRVSQ-AEQLLLVRAEKNVLVYEFGRDAIVAHIRRPPEIPAEFKMPN---ANYERINFSEADFAFGDRVVITSIFRDVLVWEVEQGRPLVMLHAPT-GILTRLLVDQTRSLVVGFIEHSR---EIHLWSLQGA---FTDGTAVDSLTAPIRAVRSARRRPRAVACCDNSDEMGVVDLDTGYLTDLYSHEGVVVDCAISSCGDYAVASVVQRNPNTTNIVWSLSERRILSEFGNVPG--HLLPCRHSSDVYIVDQAEVAFKQPFGITRLALSDGAVR 1440

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BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A1I8JLX6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 597.43 bits (1539), Expect = 5.433e-179
Identity = 455/1703 (26.72%), Postives = 788/1703 (46.27%), Query Frame = 1

Query:   31 LIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEP----EMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNAD-LVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQF-EAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTD--DDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC-----SEVGSQSLVTDLIPKFLPKNLKLIVSSTDS-----FDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLL-----VDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAW--VDQTISFHFDLKNPEMSYNCCPKSQKMYA------------KKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHI--ADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKIQIG--GSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTV--KNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFYCITNHSKSIDAPNFIVTQILCDLGVEISYTIKVLEISCLGFLTEPPCILNDDKELAFLSSN-------YRTEN-----GVGTGTNSLILWSRETHTNQNGMSKIITVKE--------------FSEQINRSVEDILSITTTKSMEDVLFIFFKTHDHEIDILHFNCHTGLVIQFMELFDVLPKQMDHKELFLSNNGCYVFYQKTSAIVNLSSGEFIGNISSDANNEYAFQCFVLKDTILILSQKTKLLAYRLPE 4932
            L    LP ++        I F + S+F DFE ER++L N  +P+L E   + +G++ + +DIKLGL+        Y  +F++   K       + P+ LLGQ             + F L+  TL+ H+     +   L+ +Y  D N   P    E +L+      PD+  +D  +      EWK T  +L+NLF+    ICL  GT+D +   +I   E +A  S  +  S  ++F P++F R+IID+KN++   N+ K D          DV   +  D  +I++ L  +L Q  N     Y + + +F +LWR   G+ +  H+ Y+  F EAFI A     V  R     +   +  ++ +D    +       A F    E  + A+++Y  D     N   +L G  N+GK    A+   E Q  L     C         +    +I     L    ++           NS E     PR+++ ++           ++++   E+        +  QSLV    P+  P N+KL++++ D           P+   + +   +   +  F +  L    + LT EQ  R+    L   + +  AS++ D         +  +      L +      +R   +FG+  +SH   Y+  S GGLTD EV ++L+LD  V++E+ +        +  + +FP S+WLL+KQE+ +++ +   DGY +      D+ + V+   L  D     K  H  +A YF G W  V + +S      +   +    P  + MY+                  FYN RKFRQL RHL   D   EL   V+F +D+LY K+ AL + E L DFQL  +   E+ L+EE+I  +  ++  +L++LA EL   L+ Y   Y N++ L+   D    +HN FVP Y   KLPGS L ST+ CP  ++S+    +  S    L +KLK+D   Y YDL  G +      SSGE++   +    ++++   R  +KVH    G  +G I+P+NW+   PFEE++ +RIT + + +  +A I+ + +S + + +L T +PI  F P  R  +  +TPDE  +FT++ E+++   +      S V+L  +P +++F  + S +AFI+C+ ++ VV+L +++ G +   +KI FEN L  +D + ++  S+     LL+ +  +V++Y++ ++ ++ HI RP ++P  FK+PN        + F+ A     DRV+I ++FRDV+V  V   + +  LHAP  GI++ + +      ++G +E S+   E+ +W        F      D LT  ++ ++       A+A C  SDEMGV+++ TG L DLYSH  VV++C +SSCG +A+ +V  +N +  NI+WSL  R+I+ EFG+      ++P +  S  Y +     +   P F +T++    G          E + +  L   P +  +D+ +  L++        Y  E        GTG   LI  S  +      + +I+ V+                  +   +++ + S    +  + V+ I       +++ L   C            ++LP   D   L  S +G Y      + + ++++G     +   A   + F+CF L D++++ S+  ++ AYR+PE
Sbjct:    8 LCSGRLPLSSLPTVSPRSITFCIISAFSDFEKEREVLRNEAYPRLYEYFRNTYGLQFRGVDIKLGLEKVNYDELDYWDLFHDIKRKFAFASHDSVPVILLGQ------------NRAFDLIRATLRAHRNPLTAQYYILDSWYRRDDNAECPDGDTEHVLLPASRQLPDIVGEDPEAKASALAEWKFTARLLANLFKIGVGICLREGTMDDQTAFEILTFELDAGISHLLSHSDLTQFRPIVFERDIIDLKNYL---NEPKADL-------YTDVELDEENDRYLIDKSLADLL-QELNDRLTTYASVDRQFSVLWRFPDGIDKRLHEEYLGDFCEAFIEAAKT-AVESRLAGKQMHADSEVVRVFDDAWTSLEHCRLLAPFSLRQEATIEAVVEYCVDFSARQNYTYLLLGGQNTGKMPAIAQAFIEIQQRL-----CE--------SPLFNQIRTCCRLDTGGVVATGAG-----ANSTEQTAPPPRNLQELVDRLS--GAGPLVLLIAGAERLVDDAGDRLPPQSLVP--APRGPPSNVKLVLTALDEAGGSVLSLAGPHLRVLHIGPQSADAYREFARHYLAERSRRLTAEQ-WRWAEQRLAGLESMFHASLLCDRLARLASGDDPADLPANSGLADLLDAEFDRLEAKFGRIAVSHAFAYVSLSGGGLTDIEVKDLLSLDDAVLDEMLVP------IEDGVRQFPSSVWLLMKQEVRLLIHEASFDGYFVNYWANGDVESAVAARYLSSDDLR--KSLHFTMADYFLGTWHGVSKPVSTVSSADDVSSADRLMPTQKLMYSIEGETGGSVTSGGGQQGSFYNERKFRQLPRHLYLSDRVPELNNLVLFSYDWLYYKSAALGLEETLRDFQLVPSN-TEVSLVEETIRKAFDILGENLNNLAAELSGSLVLYSHEYKNIKNLVRQADVRGCQHNIFVPCYSYAKLPGSALQSTVECPSNLQSM----HLSSETATLYVKLKDDVSLYKYDLERGTMLGEARTSSGELHLSADERYAVMVDNRKRSHLKVHLCSDGSFVGHILPLNWIDTMPFEEKSMFRITKVRVARRLVACIVASRMSSVIIADLATCQPIHVFKPDRRAALCDITPDERFIFTNNGEQVLVFEIGNGVQTSVVDLLAVPKRLMFTRDGS-RAFIMCEGEQKVVILYMDAKGAIEMSFKIMFENSLG-DDRLQDMRVSQ-AEQLLLVRAEKNVLVYEFGRDAIVAHIRRPPEIPAEFKMPN---ANYERINFSEADFAFGDRVVITSIFRDVLVWEVEQGRPLVMLHAPT-GILTRLLVDQTRSLVVGFIEHSR---EIHLWSLQGA---FTDGTAVDSLTAPIRAVRSARRRPRAVACCDNSDEMGVVDLDTGYLTDLYSHEGVVVDCAISSCGDYAVASVVQRNPNTTNIVWSLSERRILSEFGNVPG--HLLPCRHSSDVYIVDQAEVAFKQP-FGITRLALACG----------ESASIPHLLGRPFLTGNDRLIVCLTARDLDCARAYYIEPCLFTWNTGTGQTRLIGPSMLSAFGL--VRRILAVQPCLAGSDEGGSDVVVVYTEEEEALDSVRSPDQRRFTQSVMII-------DVETLTLRCLAP---------NLLPAGTDPDRLSFSRSGEYCV-DADNYLYSVAAGL---PLRRAAPAGFQFRCFALADSLMLFSRGRRVRAYRVPE 1602

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BLAST of AAA domain-containing protein vs. TrEMBL
Match: A0A1S3JCC0 (NACHT and WD repeat domain-containing protein 2 OS=Lingula unguis OX=7574 GN=LOC106171981 PE=4 SV=1)

HSP 1 Score: 452.21 bits (1162), Expect = 1.142e-127
Identity = 435/1794 (24.25%), Postives = 808/1794 (45.04%), Query Frame = 1

Query:   67 LPER--NVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNC-PIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSII-ICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYS-QNADLVINEDLQSVLRQYYNSCNEIYEASE--PKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSF-----QQQSNKKFIIILHDFEKCS-EVGSQSLVTDLIPKFLPKNLKLIVSST-------DSFDT---RKP-YFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLKD------FHQILAGYFNGAWVDQTISFHFD--------LKNPEMSYNCCPKSQKM-YAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHIADDY--IIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKIQI--GGSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTVKNSHNA--NILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFYCITNHSKSIDAPNFI---------VTQILCDLGVEISYTIKVLEISCLGFLTEPPCILNDDKELAFLSSNYRTENGVGTGTNSLILWSRETHTNQNGMSKIITVKEFSEQINRS---VEDILSITTTKSMEDVLFIFFKTHDHE-------------IDILHFNCHTGLVIQFMELFDVLPKQMDHKELFLSNNGCYVFYQKTSAIVNLSSGEFIGNISSDANNEYAFQCFVLKDTILILSQKTKLLAYRLPEICKIGQIELKDEVSCVSKCLDDFTIMVGCVDGSVLSYSLIDIFSPYSFLSQIKVVRNFLPTTRSP---TIELESIRSLNKTELSQEFDNLIAIKRPISEP 5223
            LPE    V+  +V  +  D   ER  L  +++PKL+E C ++ GIE++++D++ G+   +       ++F + L +   C + +  P F  L+GQ+YG+   P  IP   +++L  +L+ ++ R   +   L+ +Y  D N + P  +L  I ++  D  + +   +    Q++W  T++ L  L Q  +++C   G++D     K F+ EFE      I  +   + +  +F REI D+KN++   N            K +D+ ++ +   L I+ D Q  L    N     +   +   KF ILWR +  V    H+ YI+ F       V+  + ++A      + A  +  +D +    L   +  +   G E+I+  +  Y+T   +  P++L+G    GK+ VFA+   E    +P   +C  I R++  N   A+I   I+     + L             E E++IP D + +L  F         ++  ++     E  + E  +  LV   +P+ L  N+K+++S+        D   T   + P YF+ V  P  +     + ++  L   G+ ++++Q  R +    +     L   + V+             ++   T+ +   +  ++     GKTL+SH L Y+  S+ GL+D E+ ++L+LD  +++E+Y        +   + + P  +W+ ++ +L   L     DG ++        VE+    K  +L D       +  +A YF+ +W  +   F+F         L +   S +    SQ + +    G   YN RK+ Q+ R L      +EL K   F++ +LYNK+KAL +  ++  F L  N G E  L++ ++     VI  +++++A EL  +LL Y + +PN+R LI+ CD    +H+A VP +P +++PG PL  T+  P  ++     Q   S ++ LL K ++      +DL+ G   Y+   S+G+++  P+  +I++L+      +K+H+ +TG  +GQ+IP+N       E   +Y++  + ++   + +I T E SYL + ++   + I   N   +  +  +TPD   VFT+  E L+S ++   +   ++ L+  P  ++F  E   + F+   ++  + VL  +  G V   YKIS    L + D + ++  S     +LL+    ++++Y    EKVL+   RPS  PV FKLP R       L F  AK    D+ ++  +FR++ +  V    ++  L +P+ GI++ + + D    I+  +E   NS  + +W  D      K  +  D+LT  ++++ +    +V+   C  SDE+GVI++STG L DL +H S +    +++ G++A V+V+       N +W +E RKII EFG      + VP+ + S    +        AP +I         V ++ CDL               L F+   P +  +D+ L  L+++   E      + ++  +S E             V  +S    RS   V+ +L +   +S    + + +     E             I  L  +  +G VI   + F   P  +D   + + N    +     S I ++++G +   +          Q F L    +I  +  ++   R+ +  +I + ++   ++CV  C D  TI+VGC DG+V +Y LID           K +   +P+ + P    I+  + RS +K E S       A + PI  P
Sbjct:   18 LPESPPRVVRIYVSCTPTDMIQERNALMQQVYPKLREYCKEKHGIELQMVDLRWGVLPGIRDDHNQAELFLQELER---CQRVSAGPSFVALIGQRYGDRPLPATIPEHEYEVLRNSLRRNRSRETRDAGMLDHWYFKDTNAIPPVYVLQPISSVISDFNEMNDPEVRKAAQEQWLHTENSLRKLLQKGAELCHKEGSMDGYSKHKYFMGEFENELRHGIENAPRPRDTAFVFMREIEDLKNYVTHKN----------TPKFMDIRWNWKEEKLEIDSDSQRFLYDLKNGKVPAWMGKQNIDKFSILWRFEKVVHPDLHKAYINDFCDKFHDTVIR-LVDKAAFSYTPIPAPPI--FDTVLPHWLITQRKCRDFFGREEIMDRIYAYVTGH-SKQPLVLHGQSGCGKTCVFAKAQEEVPQWVP---DCTTIVRYLGINAESADIRQVIYGVCHQLALLEG----------EDEHHIPTDYKALLKYFFDLLEHYPEDRHLVLFFDSLETLNPEHNAHYLV--WLPEKLNPNVKIVLSTLPEKHDILDRLRTEVIKNPNYFIEV--PPLSVDNCVLLMEYYLQRVGRQISDDQ-LRVVRRAFECCSLPLFVRLTVEEVTRWRSYTKPALKMIVNTIQQAIGVIFDQLEAIHGKTLVSHSLTYLTASATGLSDGEMEDLLSLDDMILDEIY------RTWHPQVRRIPPLVWVRLRADLEPFLFQREVDGVVVSFWNHREFVEAA---KQRYLADEEMCKRIYSEMANYFSCSWHGRPKPFNFSPAVAKSMGLSSTASSADRLVLSQPLTFVGSDGTTRYNKRKYDQMPRTLYLSGRLNELNKMAFFNYLWLYNKSKALSIQHIIATFAL--NPGTESNLVKGALQACQPVILKNMNNMAAELTGRLLTYYASHPNIRHLIQQCDVEGLQHSALVPAFPYHQVPGGPLQHTLESPTPLQ---FFQLLGSDSRYLLAKERSSQNILVFDLATGEWKYDIQASAGDMHLTPDGSMIVLLDHVTEMSVKIHRSDTGKYVGQLIPLNHTT---GETSEKYKLGRMSLSNEFLCIIATFEKSYLCIASVNECKFIEVVNLNGKASVCTITPDSRFVFTNSAETLMSYDLFTLEHVCSLPLEHRPNHVVFTRE-GHRGFVSNLEENVITVLHAKE-GYVDLTYKISLTELL-KGDQISDLVVSH-NEKYLLVRGNSNLVIYGVKNEKVLSCFGRPSDTPVQFKLPQR---SLTDLNFTQAKFSQDDQYVLATIFRNIYIIDVLSGNLVTKLQSPM-GIITSLLLPDKRKQIVTHIE---NSDVIHVWNLDDA---IKHVDTLDRLTGRIQEVLVTKDNTVSFVRCHNSDEVGVIDMSTGQLCDLLTHESPLTGLSITTDGRYAFVSVQPKRPGITNKIWHMEERKIIHEFGEVGG--YSVPLHNVSTIISVCQKEIDFKAPYYISLFKFEEDRVVEVQCDL--------------TLNFVLSKPFVTKEDRYLIVLTADEYNEYKAEYNSPAICAFSLEND---------FAVASYSPADLRSCVNVKRMLDVRPHESNPYAVIVLYSCAAEEDEYSGVSSGYTSGIGFLILDVCSGAVIHVCDTF--FPPDVDLSRILI-NQDVTLCMDAQSHIYDITTGFWKCQLVPTGT---CPQRFALNGKAVIYYEDQEVYVIRVEDGKEIARCDVHMPITCVEVCHDQRTIVVGCSDGAVSAYVLID-----ERYDNAKEIVKTIPSRQLPLSTDIDGRTSRSWDKVESS-------APQTPIRLP 1702

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 149.058 bits (375), Expect = 1.722e-35
Identity = 213/958 (22.23%), Postives = 399/958 (41.65%), Query Frame = 1

Query:   79 NVINFFVCSS-FEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGL-DSYLETTAAYQQIFYEYLNKHGICDKYNC-PIFL--LGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGN-FLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIV--YAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEV-GSQSLVTDLIPKFLPKNLKLIVS----------STDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPC-QTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQEL------------SVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWV---DQTISFH-------FDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEES---INNSALVIENDLDS--LAGELIMQLLPYVSYYPNL-RFLIENCDK--VAPKHNAFVPIYPSNKLPGSPLASTIN 2796
            N+I    C S   D   ER    ++I+P++Q+ C    G+  +++D + G+ DS +      +    E      +C K +  P FL  +G +YG+   P  I    F+LLL  L    +    EG+  L Q+++ D N V P+ +L  I  +                  W  T++ L  L    +     +G +  E       N+     +   +KS D+  S VIF R++  +K         K +++K  + K +DVT     D    E L  +  + +++C     A +P F  +      +    H+ Y++ F   I +++ +G   R           +L+  +++ +A+L   + A F CG + ++    ++ + + +  + P+++ GPP SGK+ V  R   E ++ L   +    +T  +     ++    S+   +   +            +    + + R  + +L    +Q +   ++IL   +      G   L    +PK +P N+ L+VS          S  + +    YF  V     T  E  +  +  ++  G+ LT EQ +  L ++ K T   L   +++D    Q   Y ++ +I    ++ E  +L L+    + GK  + H L YI  S  GL++ E+ ++L+LD  V+ EVY N    L  + ++++FP  LW L +Q+L            +V  ++++K+ YL V+L   +                H +L+ YF G W     + I  H        D K P         +Q ++  +      N+RK  +L  HL+    ++EL + ++ + ++LY KT +  V+ ++ DF    +     EI L+ E    +  +   I+ ++DS  L  E+  +       YP+L   L   C     +      VP     + PG  L +T+N
Sbjct:    2 NIILCVTCKSHLSDLTSERNAFWDKIYPEIQDFC-QSLGLVFEVVDFRWGVSDSVINDHMTVELCLQEI----QLCQKLSVGPSFLALVGSQYGHRPIPRFISENEFELLLSKLSRKDQ----EGSMLLRQWFIKDSNSVPPKYVLQPINVV-----------------SWNLTEARLLQLLCTAALEAEKDGEMSAEQ------NDRVGDGTGFPQKSQDNP-SAVIFVRDLPPLK---------KSEQQKHTL-KFLDVTADGLLDKEAQELLTKLKERIHSAC-----ADDPGFHHIELSKGAIDRKEHKEYLENFCKQIVSQL-KGKISRQTAPPAVPGWLWLQ-QELLHHANLSKKQCAVF-CGRDGLLGKICLVMWESLNMQHGPLVVSGPPGSGKTAVLCRLAQEMRAVLGPQA---VVTLRLLGTSPLSSDVDSVLKSVCVQVCGAFNLAPPCTQTANSHDMLVRFFQSMLHKVSEQGDT-LLLILDSLDHLPHANGGHKL--RWLPKEIPPNIHLVVSTLADWSPCLESLKALNNDDKYFFQV--EPLTLEEGQLITKAYMDKAGRRLTSEQVDAVLQSFQK-TGSPLHLKLLLD-MAKQWTSYTTLSDIRLGSSVQEVISLFLDSLEGKHGKLFVRHALGYITLSRFGLSEAELQDILSLDNDVLAEVYQNR---LPPNHTLLRFPPLLWALFRQDLGDHLVERWENGIAVQFIEIVKERYLSVELRVKM----------------HTVLSEYFLGQWSQGQQKPILLHPLMTQLNADRKVP---------AQPLWFAEG---IPNFRKLHELPFHLLHAGKWEELRQLLLGNLEWLYCKTLSCGVASVIQDFTFCTDVMDCPEIRLIRECFLLLKPTIDFIDGNIDSSLLCTEITARFQALAHAYPDLIGCLYSQCQDWFASCADPVLVPRCSFMEAPGGALKNTLN 867

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 108.227 bits (269), Expect = 5.705e-23
Identity = 129/561 (22.99%), Postives = 236/561 (42.07%), Query Frame = 1

Query: 1225 PIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEV-GSQSLVTDLIPKFLPKNLKLIVS----------STDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPC-QTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLK-----DFHQILAGYFNGAWV---DQTISFH-------FDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEES---INNSALVIENDLDS--LAGELIMQLLPYVSYYPNL-RFLIENCDK--VAPKHNAFVPIYPSNKLPGSPLASTIN 2796
            P+++ GPP SGK+ V  R   E ++ L   +    +T  +     ++    S+   +   +            +    + + R  + +L    +Q +   ++IL   +      G   L    +PK +P N+ L+VS          S  + +    YF  V     T  E  +  +  ++  G+ LT EQ +  L ++ K T   L   +++D    Q   Y ++ +I    ++ E  +L L+    + GK  + H L YI  S  GL++ E+ ++L+LD  V+ EVY N    L  + ++++FP  LW L +Q+L   LV+  ++G  +   +    +E +   K  +L        H +L+ YF G W     + I  H        D K P         +Q ++  +      N+RK  +L  HL+    ++EL + ++   ++LY KT +  V+ ++ DF    +     EI L+ E    +  +   I+ ++DS  L  E+  +       YP+L   L   C     +      VP     + PG  L +T+N
Sbjct:   11 PLVVSGPPGSGKTAVLCRLAQEMRAVLGPQA---VVTLRLLGTSPLSSDVDSVLKSVCVQVCGAFNLAPPCTQTANSHDMLVRFFQSMLHKVSEQGDT-LLLILDSLDHLPHANGGHKL--RWLPKEIPPNIHLVVSTLADWSPCLESLKALNNDDKYFFQV--EPLTLEEGQLITKAYMDKAGRRLTSEQVDAVLQSFQK-TGSPLHLKLLLD-MAKQWTSYTTLSDIRLGSSVQEVISLFLDSLEGKHGKLFVRHALGYITLSRFGLSEAELQDILSLDNDVLAEVYQNR---LPPNHTLLRFPPLLWALFRQDLGDHLVERWENGIAVCGFSLRQFIEIV---KERYLSVELRVKMHTVLSEYFLGQWSQGQQKPILLHPLMTQLNADRKVP---------AQPLWFAEG---IPNFRKLHELPFHLLHAGKWEELRQLLLGSLEWLYCKTLSCGVASVIQDFTFCTDVMDCPEIRLIRECFLLLKPTIDFIDGNIDSSLLCTEITARFQALAHAYPDLIGCLYSQCQDWFASCADPVLVPRCSFMEAPGGALKNTLN 543

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 87.4261 bits (215), Expect = 1.334e-16
Identity = 81/325 (24.92%), Postives = 142/325 (43.69%), Query Frame = 1

Query: 1933 RFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWV---------------------------DQTISFH---------FDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            + G   +   L Y+  +  GLT+ E+ ++L+LD  V+ ++ +  S +L   +S ++    L   +K+EL   LV+  +++  L+V  +    +  + L       +   H +LA YF GAW                             Q++  H         +D + PE  +   C    Q ++       F N+RK  +L+ HL      D+L+  VI +F +LY   K  +  + L D   A      KE+  L  ++ +  + +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:  731 KLGSRFVFRALGYVTMARAGLTEVELEDILSLDNSVLGDIMV--SSNL---KSPLRISYDLIAQLKEELEGYLVERQVRNVTLMVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFHCDNNHFASLNISQHRNPHHQQSLHGHDKASADKHSYDRQTPEQPWVFQCNLLDQDIF-------FVNHRKMTELLFHLTRSGRTDDLMYGVIMNFSWLYTMIKIGQFDKALTDIDTAYTYTQEKELKFLASTLRSIKIKVNKNPASLSAELQQRLLPVVTSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 1043

HSP 2 Score: 71.2478 bits (173), Expect = 9.721e-12
Identity = 41/155 (26.45%), Postives = 76/155 (49.03%), Query Frame = 1

Query:   46 LPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNF----LEQYYVLDVNCVEPEMIL 498
            L      +P    +  F+C++ +D E ER  L   ++PKL++ C + +GIE +++D+  G+D     +   Q++  + L +        C + L+G+KYG++  P  + +  F+++L+         AVE       LE++Y  D N V P   L
Sbjct:  105 LALPPQHVPTGRSVRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDA--------AVEAGLDTRILEEWYCRDENSVPPAYYL 251

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 87.4261 bits (215), Expect = 1.446e-16
Identity = 81/325 (24.92%), Postives = 142/325 (43.69%), Query Frame = 1

Query: 1933 RFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWV---------------------------DQTISFH---------FDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            + G   +   L Y+  +  GLT+ E+ ++L+LD  V+ ++ +  S +L   +S ++    L   +K+EL   LV+  +++  L+V  +    +  + L       +   H +LA YF GAW                             Q++  H         +D + PE  +   C    Q ++       F N+RK  +L+ HL      D+L+  VI +F +LY   K  +  + L D   A      KE+  L  ++ +  + +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:  651 KLGSRFVFRALGYVTMARAGLTEVELEDILSLDNSVLGDIMV--SSNL---KSPLRISYDLIAQLKEELEGYLVERQVRNVTLMVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFHCDNNHFASLNISQHRNPHHQQSLHGHDKASADKHSYDRQTPEQPWVFQCNLLDQDIF-------FVNHRKMTELLFHLTRSGRTDDLMYGVIMNFSWLYTMIKIGQFDKALTDIDTAYTYTQEKELKFLASTLRSIKIKVNKNPASLSAELQQRLLPVVTSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 963

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 87.0409 bits (214), Expect = 1.521e-16
Identity = 81/325 (24.92%), Postives = 142/325 (43.69%), Query Frame = 1

Query: 1933 RFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWV---------------------------DQTISFH---------FDLKNPEMSY--NCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARN--GGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            + G   +   L Y+  +  GLT+ E+ ++L+LD  V+ ++ +  S +L   +S ++    L   +K+EL   LV+  +++  L+V  +    +  + L       +   H +LA YF GAW                             Q++  H         +D + PE  +   C    Q ++       F N+RK  +L+ HL      D+L+  VI +F +LY   K  +  + L D   A      KE+  L  ++ +  + +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + VP++ S  +  SP
Sbjct:  644 KLGSRFVFRALGYVTMARAGLTEVELEDILSLDNSVLGDIMV--SSNL---KSPLRISYDLIAQLKEELEGYLVERQVRNVTLMVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFHCDNNHFASLNISQHRNPHHQQSLHGHDKASADKHSYDRQTPEQPWVFQCNLLDQDIF-------FVNHRKMTELLFHLTRSGRTDDLMYGVIMNFSWLYTMIKIGQFDKALTDIDTAYTYTQEKELKFLASTLRSIKIKVNKNPASLSAELQQRLLPVVTSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSP 956

HSP 2 Score: 71.2478 bits (173), Expect = 1.093e-11
Identity = 40/151 (26.49%), Postives = 75/151 (49.67%), Query Frame = 1

Query:   46 LPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNF----LEQYYVLDVNCVEP 486
            L      +P    +  F+C++ +D E ER  L   ++PKL++ C + +GIE +++D+  G+D     +   Q++  + L +        C + L+G+KYG++  P  + +  F+++L+         AVE       LE++Y  D N V P
Sbjct:   28 LALPPQHVPTGRSVRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDA--------AVEAGLDTRILEEWYCRDENSVPP 170

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Match: EDO31117 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYV4])

HSP 1 Score: 156.377 bits (394), Expect = 3.991e-38
Identity = 205/946 (21.67%), Postives = 405/946 (42.81%), Query Frame = 1

Query:   73 ERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQ---IFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYP---DLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRD-DTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVL--------VPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLG----EFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLK-----DFHQILAGYFNGA-WV-DQTISFHFDLKNPEMSYNCCPKSQK-------MYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGK--EIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKL---PGSPLASTIN 2796
            E N++  F  S+F D   ER +L   ++P L++ C  +  +E +++D++ G+    E TA ++       E  N   +    N   FL G KYG    P +I  + F+ L++  +  +     E + L ++++ + N +  E +L  + A  P   D+ ++  +     ++EW K       + +  + +    G L  E V K + +  E      I    D +   + + REI DI   I      KD+K    I    D+    + D    E L  + RQ     +++   +  ++ + W       S+  H  Y++ F                 +   DL+         + +  L+ + F     G ++I+    DYL   D+  P+++YG   SGK+ + A   F  +  L  ++ C F  RF+ ++   +   L+I   +   I +    E++ ++  E    + R    +L +    + +  +++L   ++ S   +  L+ + +PK L  ++K+++S    +    P     L        VP  ++   +  +   L++  + LT EQ    ++ + K         + +   + +   + S  ++   +LG    E       R  ++ GK L S  L Y+  +  GLT+ E+ ++L+LD  V+++VY      +   + +V+ P  LW  ++ ++   LV+   DG  +V        E+    +  +LK     D H ++A +F G  W        H  L   + +    P + +       M++K+     +N RK  +L  HLV    ++ L + V+F+F+++  K KA  ++ +L D+  A       +I L+++++  S+  I++DL+SLA +LI +LL +   +P +  L+E   +     N  V I P N     PG PL + ++
Sbjct:   20 ESNIVRIFTSSTFTDTFEERNLLMRDVYPSLRKYC-QQHSLEFQVVDMRWGVRD--EATADHKTSDLCIQEIKNCQRLTQGPNYVCFL-GNKYGYRPVPYKINAEEFESLVDIAREVENVKKEEVDLLLEWFLKNENALPAEYVLQPVTAKLPYYNDMREEVHDKYSQQREEWWKISVTFQRVLRISAHVAGRRGKLTEEQVHKYYKSVTEHEIEHGILNCADPEAQTLCYIREIEDINLNI------KDEK----IPLYTDIADGGH-DAEAQEHLFRLKRQRV--LDKLKAENVVQYSVPWNSRGINASDRRHHEYLENF---------------CNRFESDLTR--------LIDRSLECSAFR----GRQEILSRARDYLCRYDSARPLVVYGASGSGKTSIMAVIAFRVKEWLGDNAVCIF--RFLGTSPGTSNTLLTI-KSVCEQIHQVFGLESLKEDVAEDYTELVRHFHELLSTLSVSAERPLVLVLDSVDQLSPSYNAHLM-NWLPKSLSDHIKIVISVLPGYYEILPTLQRSLTDTNCYIEVPTLSRDTGHEILDAWLDSKHRTLTPEQRVLVMAAFDK-----CPQPLFLKLIFAEASEWASYTDVSGVSLGANVPEAIGFLFERLERKHGKMLFSRALQYVTAARSGLTENELEDILSLDDDVIDDVYQYWDPPV---EGVVRLPNLLWARVRSDIDEFLVERQADGKTVVAWYHRQFWEAC---ERMYLKDGVKVDAHALMAEFFLGEFWTWGGGRKKHIVLTRRQKAL---PDADRQVSAQPLMFSKE----IFNLRKLSELPYHLVHSKQFNALSQEVLFNFEWIMAKVKAQSLNSVLADYDTALQAKPDLDIRLVQDTLILSSSNIKHDLNSLAPQLIGRLLAFKGKFPRIASLLEQAYRWIYARNIPV-IAPMNACLISPGGPLITNLH 898

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BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Match: EDO37261 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG70])

HSP 1 Score: 80.1073 bits (196), Expect = 4.423e-15
Identity = 143/711 (20.11%), Postives = 287/711 (40.37%), Query Frame = 1

Query:  148 RIFPKLQEQCFDEFGIEIKLIDIKLGL-----DSYLETTAAYQQIFYEYLNKHGICDKYNCP---IFLLGQKYGNV-LPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEP-KFRILW-RDDTGVSEAHHQIYID----QFEAFITAKVVEGVAER-AKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTS---NCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCS-EVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTR-----KPYFLN----VLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFY-----ALN--LNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDG 2172
            +++PKL+E C  + G E +++D++ G+     D +  T    ++I          C K +     I LL +KYG   L P+ +P+   +++      H    +   + L+++Y LD NC+    IL  +                                                      +++ F     + +RK     +S     R+   +KN IV +  K     ++ + K +D T           D  S+L+Q  +S  +I   +    ++I W +     +   H+ Y++     F+  +  K+ + ++E  + +I   +    ++ + + C + L +        G + ++ ++ DYL +     P++L+G    GK+ + A    +      H   C  + RF+ +   + TI  +  SI  QI  +          LK+  E+          +L S    + +  +++L   ++ S E G++ L  D +PK LP + K+IVS+      R     K  F N    + VP    ++ +  +   L  +G+ L   Q +  +S + +         + +   +++   ++S  + P QT    Y     A+N  L R   + G+ L+ H L Y+  +  GLT+ E+ ++L+ D +V+++V+        +   I + P  LW+ I+ +L   LVD   +G
Sbjct:   24 KVYPKLKEFC-KQKGYEFQVVDMRWGVRDVATDLHETTDLCIREI--------RACQKISAGPNFITLLSEKYGYCPLVPV-MPSDELQMI------HANCNSTGKDLLDKWYRLDTNCIPASYILQPVST----------------------------------------------------WIHGFFTEGDKKVRKQAQDDWS-----RDCTALKNAIVTAIHKAHSD-QATVHKYMDTTIGDEI-----TDRMSMLQQLKSSMKQILGINNMLVYKIKWTKKGIDPTNDEHRQYLNTFCRDFQRVLETKITQSISENTSSEIESPIYEEVVQ-HMMFCQSKLDMFH------GRQAVLNSIGDYLREG-LGQPLVLHGCSGCGKTSIMAMAA-KCARDWIHPEAC-VVLRFLGTTPKSSTIRRLMKSICEQIKCVYRLTTSIPQGLKDMVEL-------FPSLLAS--ATAKRPLLVLLDSLDQLSPEDGARLL--DWLPKHLPGHCKMIVSTLPGAQYRCFPKLKAMFKNDKLFISVPSLPHSDVSDILSMWLQQSGRTLQPAQRDLVMSAFSQ-----CPLPLFLKISFDEACRWHSYTD-PGQT--RLYGSVRDAINGLLERIEAKHGRILVQHALGYLTAARSGLTETELDDILSSDDEVLDDVF------QYWTPPIRRLPPLLWVRIRADLDSYLVDRGSEG 620

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BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Match: EDO40517 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6Z9])

HSP 1 Score: 66.2402 bits (160), Expect = 8.329e-11
Identity = 100/461 (21.69%), Postives = 190/461 (41.21%), Query Frame = 1

Query:  877 EDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAH--HQIYID----QFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQ-----SNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDS-----FDTRKPYFLN----VLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTL-----GEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV 2184
            ++LQS +R   +  N I+      + I W  +    E +  H  Y+     +F   +  K+ + + +RA     D    F +        +L+   F     G EDI+  +  Y++      P++LYG    GK+ + A T     S   +  E   + RF+ +    + I L +    SA +     F T  K        +P+D + +L  FQ +     SN+  ++IL   ++ +       +   +P+ LPK++ ++VS+        +   K   L+    V V           + + L+N  + LT+ Q +  L+ + +         + +   Y+    + S   +    L     G   AL   R  +R G  L+ H L YI  +  GL++ E+ ++L+ D++V++EV+        +   + + P  LW  I+ EL+  +V+   DG  +V
Sbjct:  215 KNLQSEIRSTLDKSN-IFS-----YDIKWTSEGVTPEGNLTHGQYLGKLCTEFYDVMKKKITDAITKRAAGEVRDKEHLFQEVAQHATFCNLKCENFH----GREDILEKIRTYISGSGQK-PLVLYGDSGCGKTSLVAMTAKLVPSWTEY--EPVVVLRFLGTTPDSSNIRLVLR---SACLQLCKAFGTSTKV-------VPQDYQDLLREFQDRLKMAKSNRPIVVILDSADQLTTTDDAHQMV-WLPRKLPKHVYVLVSTLKDPKYACYPALKKLLLDSNCFVEVSSLPSEVACNILTSWLSNDNRRLTDSQRKIVLNAFNR-----CPLPLYLRLAYDHAVTWKSYTPLEKSVLEKNVQGMIKAL-FKRLERRHGTVLVRHALAYITAAKHGLSEPELEDILSCDEEVLDEVF------QYWTPPVRRIPPLLWARIRAELNSYVVECGTDGARVV 639

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BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Match: EDO34994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMT6])

HSP 1 Score: 62.7734 bits (151), Expect = 1.198e-9
Identity = 84/378 (22.22%), Postives = 166/378 (43.92%), Query Frame = 1

Query: 1132 LQINKFAKFGC----GYEDIVYA------MLDY-LTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFV--TSNCTIAEIFL-SIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCS-EVGSQSLVTDLIPKFLPKNLKLIVSST-----DSFDTRKPYFLN---VLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRF----GKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV 2184
            LQ   F +  C    G ED++ +      M  Y + D   N P+++YG    GK+ V +      +  L  D+ C  + R++  T + ++  + + S+  QI A+  ++  F  I  + KE++ +  R +    +       +  +I+L   ++ S E G++ L    +P  LP ++ L+VS+      + F   K +      VLVP+  Q +    + + L    + L+ +Q +  +   L+      +  + V   +++   + S   +    L       +N  ++R     G  L+S  L Y+  +  GLT+ E+ ++L+ D  V+++VY        +   + + P  LW+ I+Q+L   LV    DG  +V
Sbjct:  279 LQHLSFCQSKCEQFYGREDVLLSCRLILNMRSYDVLDVCRNRPLVIYGESGCGKTSVVSMVAMRSREWLRGDT-C-VVVRYIGTTPDSSLVRLLVRSVCQQICAVYEKDPSF--IRNDIKELKEDFIRCLRMATV------ERPLLIVLDSLDQLSAEDGARQL--SWLPMTLPDHVHLVVSTIPEVKYECFPVLKAFLPPESFVLVPKLPQKDAAEILVSYLRMEHRTLSTDQQD-IVQQALQEC----SLPIFVRVAFDEAIRWKSYSPLDETVLQHTVRGAINSLFERVERQHGHVLVSRALGYVTAAKSGLTETELEDLLSCDDFVLDDVY------QYWTPPVRRIPPLLWVRIRQDLESYLVTRGADGAQVV 633

HSP 2 Score: 53.1434 bits (126), Expect = 8.878e-7
Identity = 45/146 (30.82%), Postives = 68/146 (46.58%), Query Frame = 1

Query:   79 NVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNC-PIFL--LGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDI 507
             V+  F  S+F D E ER  L  +  PKL+  C  E G E +++D++ G+    E +A         L +   C + +  P F+  LGQKYG    P RIP   F  +   L+N   R     + +E+++  D N V P  +L  I
Sbjct:    2 KVVRIFTSSTFTDTEAERNALMLKTIPKLKLFC-QEKGYEFQVVDMRWGVR---EQSADDHTTVDLCLKELKACQQLSTGPNFVTFLGQKYGFRPFPPRIPGDEFLQIAAALENEHDR-----SLIEKWFKCDFNGVPPAYMLQPI 138

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Match: EDO47108 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNA9])

HSP 1 Score: 62.3882 bits (150), Expect = 1.425e-9
Identity = 99/432 (22.92%), Postives = 183/432 (42.36%), Query Frame = 1

Query:  946 KFRILWRD---DTGVSEAHHQIYIDQ----FEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNC-TIAEIFLSIFLQISAI-ILRNNQFETILKNSKEIENNIPRDIEGILLSFQQ-----QSNKKFIIILHDFEKCS-EVGSQSLVTDLIPKFLPKNLKLIVSS--TDSFDTRKPYFLNVL-------VPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKD 2169
            +F + W +   D   SE H Q YI++    F   +T  +   V+ERA+    D  A  +  +   C     + K   F  G E+ + ++   L  +   +  +LYG    GK+ + A+              C  +  ++      +   F+ I    S I  L  +  + + + S E  +N+P D++ +   F +      + K  +++L   ++ S + G + L  D +PK LP N+ L++S+   D ++   P    +L       VP     E +  +   L  + K LT+ Q +  L  + +    +       +    +++       +P    G   AL  +R  +  G+ L+SH L YI  S  GLT+ E+ ++L+LD  V+N+VY        +   I + P  LW+ I+ ++S  L+D   D
Sbjct:  215 QFDVKWAENGIDPSESEEHAQ-YIEELCTSFYETLTGMIGTAVSERAEVEVKDPLAEEVFSHLTFC-----LKKCEAFH-GREEFLDSVKQALLSNGQRI-TVLYGESGCGKTSIMAKI-------------CALVKEWLRKEAVAVVPRFVGISPDSSGIRTLLRSVCQQLCRVSGENADNVPEDMKSLREYFPECLKSAATCKTIVLMLDSLDQLSPDDGGRQL--DWLPKSLPDNIYLVMSTLPGDEYECL-PNLQAILPDACLKEVPSLPLAEADSILTNLLQASRKCLTDSQKQAVLEAFQQCQLPLYLMLAFGEACRWKSYTPEDQITLPPSVKGIINAL-FDRVERVHGRILVSHALGYITASKNGLTEPELEDLLSLDDDVLNDVY------QYWTPPIRRLPPLLWIRIRADISDFLIDRGAD 615

HSP 2 Score: 51.9878 bits (123), Expect = 2.282e-6
Identity = 40/151 (26.49%), Postives = 72/151 (47.68%), Query Frame = 1

Query:   79 NVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGL-----DSYLETTAAYQQIFYEYLNKHGICDKYNC-PIFL--LGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDI 507
             ++  F  S+F D  +ER  L  RI+P++++ C  + G E +++D++ G+     D +L +    +++          C + +  P F+  LGQKYG    P +IP   F+ LL  + N + +       L  ++  D N V  E +L  I
Sbjct:    1 KIVRIFTSSTFTDTSVERNTLMERIYPRIKQFC-QQHGYEFQVVDMRWGVRDESTDDHLTSELCMREL--------RACQELSTGPNFITFLGQKYGYRPFPPKIPATEFENLLSAVNNVEDQ-----QLLRHWFRRDDNIVPAEYLLQPI 137

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Medaka
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:101165765])

HSP 1 Score: 98.2117 bits (243), Expect = 6.358e-20
Identity = 131/582 (22.51%), Postives = 250/582 (42.96%), Query Frame = 1

Query: 1225 PIILYGPPNSGKSIVFARTIFE----FQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEG---ILLSFQQQS--NKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNI-FIQTQLNNTGKLLTEEQNERFLSNYLKFTDG----------ILTASVIVDYFYNQNFIYNSMEEIP----CQTLGE-----FYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISF------HFDLKNPEMSYNCCPKSQKMYAKKSGN------------------------VFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGG--KEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            P++++G P +GK+++ +    +     Q  +  +++   I RF+ S+       LS  L+     L  +  E I  N + + + +P  I+    +L++   +S  ++  +I+L   E+ S+   ++     +P  LP+ ++++VS+  +    K   L  L        + +  IQ       ++L ++     L    K T G            T  + V+  Y +   + S +++     C T+ E     FY++       + G+  +   L YI  +  GLT+ E+ ++L+LD  V+ +V +       Y ++ ++    L   +++EL   L++  +++  LLV  +    +  + L       +   H +LA YF GAW             HF   N  +S++  P  Q+ + K S +                         F N+RK  +LV HL      D+L+  VI +F +LY   K  +  + L D  LA +    KE+  L  ++    + +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + +P++ S  +  SP
Sbjct:  413 PMVVFGGPCTGKTLLLSEVAKQAYTWLQKEMGPETDPVVIVRFIGSS------QLSTDLRT----LLQSICEQIAINYRCLIHFLPNKIQEMRELLINLLGESSFHRPLVIVLDSLEQLSD-ADEARKLWWLPIQLPRTVRIVVSTLPN----KHGILQKLRHLIHDDGYYVELIQRDRKACSQMLKQQ----LLGVKRKVTSGQQIYVNEALAKCTLPMFVNLIYREVVHWRSHKDVDDKSLCSTVHESIEQLFYSVE-----NKLGQRFVFRALGYITMAKAGLTEVELEDILSLDNIVLGDVIV-----ATYLKNPLRISYDLVAKLREELEGYLIERQVRNIALLVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFTYDNNHFTSLN--ISHHKNPHHQQSHEKASSDKYSYDRQTPEQPWVFQCNLLEPDIFFVNHRKMTELVYHLTRSGRTDDLMFGVIMNFSWLYTMIKIGQFEKALTDIDLAYSCSQEKELKFLATTLRGVKVKVLKNPASLSAELQQRLLPVVASLPKLRHLLLECDKDGPKYCSIMPLHSSMDVTYSP 963

HSP 2 Score: 70.8626 bits (172), Expect = 1.484e-11
Identity = 37/144 (25.69%), Postives = 74/144 (51.39%), Query Frame = 1

Query:   67 LPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMIL 498
            +P    +  F+C++ +D E ER  L   ++PKL++ C + +GIE +++D+  G+D         Q++  + L +        C + L+G+KYG++  P  + +  F+++L+          ++ + LE++Y  D N V P   L
Sbjct:   35 VPSGRSVRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDNPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDA----AVEAGLDTHILEEWYCRDENSVPPAYYL 174

[Close]

Query: 1225 PIILYGPPNSGKSIVFARTIFE----FQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEG---ILLSFQQQS--NKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNI-FIQTQLNNTGKLLTEEQNERFLSNYLKFTDG----------ILTASVIVDYFYNQNFIYNSMEEIP----CQTLGE-----FYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISF------HFDLKNPEMSYNCCPKSQKMYAKKSGN------------------------VFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGG--KEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            P++++G P +GK+++ +    +     Q  +  +++   I RF+ S+       LS  L+     L  +  E I  N + + + +P  I+    +L++   +S  ++  +I+L   E+ S+   ++     +P  LP+ ++++VS+  +    K   L  L        + +  IQ       ++L ++     L    K T G            T  + V+  Y +   + S +++     C T+ E     FY++       + G+  +   L YI  +  GLT+ E+ ++L+LD  V+ +V +       Y ++ ++    L   +++EL   L++  +++  LLV  +    +  + L       +   H +LA YF GAW             HF   N  +S++  P  Q+ + K S +                         F N+RK  +LV HL      D+L+  VI +F +LY   K  +  + L D  LA +    KE+  L  ++    + +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + +P++ S  +  SP
Sbjct:  413 PMVVFGGPCTGKTLLLSEVAKQAYTWLQKEMGPETDPVVIVRFIGSS------QLSTDLRT----LLQSICEQIAINYRCLIHFLPNKIQEMRELLINLLGESSFHRPLVIVLDSLEQLSD-ADEARKLWWLPIQLPRTVRIVVSTLPN----KHGILQKLRHLIHDDGYYVELIQRDRKACSQMLKQQ----LLGVKRKVTSGQQIYVNEALAKCTLPMFVNLIYREVVHWRSHKDVDDKSLCSTVHESIEQLFYSVE-----NKLGQRFVFRALGYITMAKAGLTEVELEDILSLDNIVLGDVIV-----ATYLKNPLRISYDLVAKLREELEGYLIERQVRNIALLVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFTYDNNHFTSLN--ISHHKNPHHQQSHEKASSDKYSYDRQTPEQPWVFQCNLLEPDIFFVNHRKMTELVYHLTRSGRTDDLMFGVIMNFSWLYTMIKIGQFEKALTDIDLAYSCSQEKELKFLATTLRGVKVKVLKNPASLSAELQQRLLPVVASLPKLRHLLLECDKDGPKYCSIMPLHSSMDVTYSP 963

HSP 2 Score: 70.8626 bits (172), Expect = 1.484e-11
Identity = 37/144 (25.69%), Postives = 74/144 (51.39%), Query Frame = 1

Query:   67 LPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMIL 498
            +P    +  F+C++ +D E ER  L   ++PKL++ C + +GIE +++D+  G+D         Q++  + L +        C + L+G+KYG++  P  + +  F+++L+          ++ + LE++Y  D N V P   L
Sbjct:   35 VPSGRSVRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDNPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDA----AVEAGLDTHILEEWYCRDENSVPPAYYL 174

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Medaka
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:101165765])

HSP 1 Score: 98.2117 bits (243), Expect = 7.525e-20
Identity = 130/580 (22.41%), Postives = 251/580 (43.28%), Query Frame = 1

Query: 1225 PIILYGPPNSGKSIVFARTIFE----FQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEG---ILLSFQQQS--NKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNI-FIQTQLNNTGKLLTEEQNERFLSNYLKFTDG----------ILTASVIVDYFYNQNFIYNSMEEIP----CQTLGE-----FYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDV-IKDGYLLV--DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTIS-FHFD---LKNPEMSYNCCPKSQKMYAKKSGN------------------------VFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGG--KEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSP 2778
            P++++G P +GK+++ +    +     Q  +  +++   I RF+ S+       LS  L+     L  +  E I  N + + + +P  I+    +L++   +S  ++  +I+L   E+ S+   ++     +P  LP+ ++++VS+  +    K   L  L        + +  IQ       ++L ++     L    K T G            T  + V+  Y +   + S +++     C T+ E     FY++       + G+  +   L YI  +  GLT+ E+ ++L+LD  V+ +V +       Y ++ ++    L   +++EL   L++  +++  LLV  +    +  + L       +   H +LA YF GAW       F +D     +  +S++  P  Q+ + K S +                         F N+RK  +LV HL      D+L+  VI +F +LY   K  +  + L D  LA +    KE+  L  ++    + +  +  SL+ EL  +LLP V+  P LR L+  CDK  PK+ + +P++ S  +  SP
Sbjct:  403 PMVVFGGPCTGKTLLLSEVAKQAYTWLQKEMGPETDPVVIVRFIGSS------QLSTDLRT----LLQSICEQIAINYRCLIHFLPNKIQEMRELLINLLGESSFHRPLVIVLDSLEQLSD-ADEARKLWWLPIQLPRTVRIVVSTLPN----KHGILQKLRHLIHDDGYYVELIQRDRKACSQMLKQQ----LLGVKRKVTSGQQIYVNEALAKCTLPMFVNLIYREVVHWRSHKDVDDKSLCSTVHESIEQLFYSVE-----NKLGQRFVFRALGYITMAKAGLTEVELEDILSLDNIVLGDVIV-----ATYLKNPLRISYDLVAKLREELEGYLIERQVRNIALLVWANRHLHLIAQKLYLSNEEDVHQMHSLLAEYFLGAWAGGRKKIFTYDNNHFTSLNISHHKNPHHQQSHEKASSDKYSYDRQTPEQPWVFQCNLLEPDIFFVNHRKMTELVYHLTRSGRTDDLMFGVIMNFSWLYTMIKIGQFEKALTDIDLAYSCSQEKELKFLATTLRGVKVKVLKNPASLSAELQQRLLPVVASLPKLRHLLLECDKDGPKYCSIMPLHSSMDVTYSP 953

HSP 2 Score: 70.4774 bits (171), Expect = 1.655e-11
Identity = 37/144 (25.69%), Postives = 74/144 (51.39%), Query Frame = 1

Query:   67 LPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMIL 498
            +P    +  F+C++ +D E ER  L   ++PKL++ C + +GIE +++D+  G+D         Q++  + L +        C + L+G+KYG++  P  + +  F+++L+          ++ + LE++Y  D N V P   L
Sbjct:   35 VPSGRSVRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDNPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDA----AVEAGLDTHILEEWYCRDENSVPPAYYL 174

[Close]

BLAST of AAA domain-containing protein vs. Ensembl Medaka
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 90.1225 bits (222), Expect = 1.849e-17
Identity = 185/883 (20.95%), Postives = 343/883 (38.84%), Query Frame = 1

Query:  193 IEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCP---IFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEG-NFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRI----LWRDDTGVSEAHHQIYID--------QFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYED-------IVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSN----CTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVL-----------VPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVY-INHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVD-----LATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALV-IENDLDSLA------GELIMQLLPYVSYYPNL 2688
            + ++++D+  G+ +Y        +I  + +    +C + +     I LLG +YG+   P  I  K F++ L  L         EG   L  ++  D N V P  +L  I  +                  W+ T++ L  L ++ +    + G +  E     + +       + +    D   + ++F RE    K       ++K  +    + K +D T    A+++++ + Q +L +     +++Y  S+    +    L R         H  Y+D        Q +A I A V     E  KKI  ++     K   ++  A       A+   G          I  AM +  +    + P++++G    GK+ +  + + E Q  L  ++    + RF+ ++      + ++  SI LQ+S+             +  E++    R+I    L    Q     +I+L   E+ +E    S     IP  LP  + L+V    S DT    F+N+            V   ++ E    +++ L  + + LT EQ +  L ++   T   L   +I+    N        E++      E  +  L+R   +  K L+   L YI  +  GL + E+ +V++LD  V++EVY   H  +     S+++ P  LW  +K++L   L +   +G  ++      L+  V    L  ++       H+IL  YF G W  +         +  +S    P     +A    N+    RK + L  HL+    ++EL + VI    YL   T    VS ++ D        + +   E  +   ALV I+  LD L       GEL+ +L    + +P+L
Sbjct:   16 LPVQVVDLHWGIGNYPFGDHEACEISLQEIK---MCKRLSAGPNFIALLGNRYGHRALPRLISEKQFEVYLSKLSQ-----TPEGIKQLRLWFRKDTNAVPPTYVLQPITDV----------------DSWRFTETQLLQLLRSAASEAEAEGEITAEQKQSFYTSVTAQELEQGLWIG-DHPPNALLFLRENPKQK-------KQKGKEWPKRLAKFMDAT----ANMLLDPESQKLLAELK---SQLYATSQKTTNLHCVELSRGIIDPKRKEHAQYLDSLCQQFISQMKARIEAVVSLRTTESQKKILGNVEEDEDKLSLVLEEAKQHTTMTAELCEGLHGREGILGKICLAMWE--SGQKCHSPLVVHGAAGMGKTALLCKVVREMQRVL--ETRVVLVIRFLAAHHPQRPALDQVLHSICLQVSSACGLVPPTPMTAGSPTELQKFF-RNI----LEEASQQGYTLLIVLDALEQLAEQ-HHSHKLHWIPTNLPPKVHLLV----SMDTCSEAFVNMRLKTDSLENFFEVERLSRDEGERIMESHLRASQRTLTAEQKDVALQSF-TLTGCPLHLKLILSAVQNWTSFTPLTEQLLGNNTEEVMSQLLHRLEHKHRKELVGGALGYIALARDGLLEAELYDVMSLDDDVISEVYRYTHPPT----PSLIRLPPLLWARLKRDLKDHLEERWTNGVAVIAFNHRCLSEVVLGHYLTSERQGRC---HKILGEYFLGRWSGKLKPVALPGLSLLLSDRKVPPQPLWFAPGLANI----RKLQALPHHLLHAGLWEELRQEVI-SMSYLCYGTSVCGVSSVIHDLD---QCSQYMDCTETGLIRDALVLIKPGLDFLDGMSLFYGELLARLSALSAVFPSL 829

[Close]

BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000012845.1 (SMESG000012845.1)

HSP 1 Score: 3548.83 bits (9201), Expect = 0.000e+0
Identity = 1738/1751 (99.26%), Postives = 1748/1751 (99.83%), Query Frame = 1

Query:   10 MESFQNLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHIADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKIQIGGSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTVKNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFYCITNHSKSIDAPNFIVTQILCDLGVEISYTIKVLEISCLGFLTEPPCILNDDKELAFLSSNYRTENGVGTGTNSLILWSRETHTNQNGMSKIITVKEFSEQINRSVEDILSITTTKSMEDVLFIFFKTHDHEIDILHFNCHTGLVIQFMELFDVLPKQMDHKELFLSNNGCYVFYQKTSAIVNLSSGEFIGNISSDANNEYAFQCFVLKDTILILSQKTKLLAYRLPEICKIGQIELKDEVSCVSKCLDDFTIMVGCVDGSVLSYSLIDIFSPYSFLSQIKVVRNFLPTTRSPTIELESIRSLNKTELSQEFDNLIAIKRPISEPIVAHERREFSNIY 5262
            MESFQ+LLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYI+QFEAFITAKVVEGVAERAKKINL+LSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYN NFI NSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLID+KNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGN+FYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQT+MALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANE+SKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHIADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKK+QIGGSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTVKNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGF+CITNHSKSIDAPNFIVTQILCDLGVEISYTIKVLEISCLGFLTEPPCILNDDKELAFLSSNYRTENGVGTGTNSLILWSRETHTNQNGMSKIITVKEFSEQINRSVEDILSITTTKSMEDVLFIFFKTHD+EIDILHFNCHTGLVIQFMELFDVLPKQMDHKELFLSNNGCYVFYQKTSAIVNLSSGEFIGNISSDANNEYAFQCFVLKDTILILSQKTKLLAYRLPEICKIGQIELKDEVSCVSKCLDDFTIMVGCVDGSVLSYSLIDIFSPYSFLSQIKVVRNFLPTTRSPTIELE IRSLNKTELSQEFDNLIAIKRPISEPIVAHERREFSNIY
Sbjct:    1 MESFQDLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIEQFEAFITAKVVEGVAERAKKINLNLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCTIAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRKPYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNHNFINNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDEKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNIFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNGGKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENCDKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKELLIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQIIKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTRMALIITNEVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNVEKNQLNSAVELQGIPLQMLFANEKSKKAFIVCDQQKSVVVLDLESAGVVRKCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLNHITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVCTVSDNKIIKTLHAPVGGIVSEIHIADDYIIGKVEQSQNSAEVMIWKTDPKCLFFKIENNQDKLTRCVKKLQIGGSVAIASCVESDEMGVIEISTGTLVDLYSHSSVVINCCLSSCGKWALVTVKNSHNANILWSLETRKIIFEFGSSTNTEFIVPMKSKSGFFCITNHSKSIDAPNFIVTQILCDLGVEISYTIKVLEISCLGFLTEPPCILNDDKELAFLSSNYRTENGVGTGTNSLILWSRETHTNQNGMSKIITVKEFSEQINRSVEDILSITTTKSMEDVLFIFFKTHDYEIDILHFNCHTGLVIQFMELFDVLPKQMDHKELFLSNNGCYVFYQKTSAIVNLSSGEFIGNISSDANNEYAFQCFVLKDTILILSQKTKLLAYRLPEICKIGQIELKDEVSCVSKCLDDFTIMVGCVDGSVLSYSLIDIFSPYSFLSQIKVVRNFLPTTRSPTIELEPIRSLNKTELSQEFDNLIAIKRPISEPIVAHERREFSNIY 1751

[Close]

BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 92.8189 bits (229), Expect = 1.943e-18
Identity = 163/764 (21.34%), Postives = 317/764 (41.49%), Query Frame = 1

Query:   25 NLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNC-PIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQ--QEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSE--AHHQIYIDQFEAFITAKV----------VEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFAR--TIFE---FQSSLPHDSECH-------------FITRFVTSN---CTIAEIFLSIFLQISAIILRNNQFE--TILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC---SEVGSQSLVT--DLIPKFLPKNLKLIVS-STDSFDTRKPYFLNVLVPEFTQT----------EFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLN--RWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELS 2142
            N ++   + FT   +     +  F+ S+F DF++ER +   ++ P L   C +++G+ ++L D++ G+  Y       + +    L +  +C K +  P F  L+G +YG    P  +P+  F+++ + + ++   F  E   + +++  DVN   P   L+ I+   P  Y    + II  +   EW K +  +    +   KI +S G    E   K+  +  E  F   +    D  F  VI  ++      +    N   ++ +     K ID     N +++     Q++L ++ NS  ++      KF + W  + G+++    H+ Y+D     +   +          +E  + R   + L L +  +  +            F  +G     +   +L  L D + + PII++G    GK+   A+  T+ +   F ++  + SE +              + RF+ ++    ++ ++  S+  QI        +F   T L + K + N + + I     S+QQ      III    ++    S   ++SL    D IP  LP  + +I+S  T++F+++        + EF             E  +  Q+ L +  + LT+ Q    +S  +    G+     +      ++  Y SMEE   +   E  A+N       +++G  L+SH L Y+     GLT+ E+ ++L+L   V+NEVY  H   +     I++ P  +   I  +LS
Sbjct:   36 NKILSGCINFTDIGVSPPREVRIFLSSTFSDFKVERNLFIKQVIPSLHSIC-NDYGLSLRLCDMRWGVTDYAVNEHLVESLC---LKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDN---FPKEAELISKWFQKDVNSEPPVYNLLPIKTFIPK-YGDYEDEIIRRESGHEWWKVEENIRRCLKKSFKIAISQGLFTNEQKRKLIKSVTETEFWTAV---MDDNF--VINKQKASRCLAYERQINGLMNNLQSECAIKYIDYVTRDN-EIICESSAQNLLLEFKNSIKKVELRHFRKFNVPWVSN-GITDLLISHKNYLDDLSTTVICDIKALIVEHMSAIEKHSGRFNNLKLHLQSEVIHHWQFCWQ-----RCFNFYG---RKVQQEILFNLIDRNYDKPIIVHGDSGCGKTAFLAKVSTVIQEKFFNTTGENKSETNENSNGFQLNQTPVIVLRFIGTSMYSSSLHQLLFSVCFQIQLAYKLKVKFRKMTSLSSLKWLFNYLIQQISH--YSYQQSP---LIIIFDSIDQLFMFSNTLNESLSNSLDWIPVPLPPGIHIIISLITENFESKCFQMFQNRLSEFQHKFIHINYFDDKEVVLICQSLLEHKKRTLTDLQMNLIISKLINNPRGLYIKLALEQAVTWKS--YMSMEECIIKDCVE-SAVNFKFACLEEKYGLLLMSHALGYLTLGYNGLTEIELEDLLSLQDNVLNEVYQYHDPPI---SGIIRLPSLMCSRIHSDLS 765

[Close]

BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 92.0485 bits (227), Expect = 3.822e-18
Identity = 189/904 (20.91%), Postives = 363/904 (40.15%), Query Frame = 1

Query:   25 NLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNC-PIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQ--QEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSE--AHHQIYIDQFEAFITAKV----------VEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFAR--TIFE---FQSSLPHDSECH-------------FITRFVTSN---CTIAEIFLSIFLQISAIILRNNQFE--TILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC---SEVGSQSLVT--DLIPKFLPKNLKLIVS-STDSFDTRKPYFLNVLVPEFTQT----------EFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLN--RWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV----------DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELL 2532
            N ++   + FT   +     +  F+ S+F DF++ER +   ++ P L   C +++G+ ++L D++ G+  Y       + +    L +  +C K +  P F  L+G +YG    P  +P+  F+++ + + ++   F  E   + +++  DVN   P   L+ I+   P  Y    + II  +   EW K +  +    +   KI +S G    E   K+  +  E  F   +    D  F  VI  ++      +    N   ++ +     K ID     N +++     Q++L ++ NS  ++      KF + W  + G+++    H+ Y+D     +   +          +E  + R   + L L +  +  +            F  +G     +   +L  L D + + PII++G    GK+   A+  T+ +   F ++  + SE +              + RF+ ++    ++ ++  S+  QI        +F   T L + K + N + + I     S+QQ      III    ++    S   ++SL    D IP  LP  + +I+S  T++F+++        + EF             E  +  Q+ L +  + LT+ Q    +S  +    G+     +      ++  Y SMEE   +   E  A+N       +++G  L+SH L Y+     GLT+ E+ ++L+L   V+NEVY  H   +     I++ P  +   I  +LS  ++    D  + +           L   V    +++  +  + D++ I  G        Q      ++KN +   N  P ++K             RK   L  HLV      EL K    +  +L +  K   V EL+
Sbjct:   36 NKILSGCINFTDIGVSPPREVRIFLSSTFSDFKVERNLFIKQVIPSLHSIC-NDYGLSLRLCDMRWGVTDYAVNEHLVESL---CLKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDN---FPKEAELISKWFQKDVNSEPPVYNLLPIKTFIPK-YGDYEDEIIRRESGHEWWKVEENIRRCLKKSFKIAISQGLFTNEQKRKLIKSVTETEFWTAV---MDDNF--VINKQKASRCLAYERQINGLMNNLQSECAIKYIDYVTRDN-EIICESSAQNLLLEFKNSIKKVELRHFRKFNVPWVSN-GITDLLISHKNYLDDLSTTVICDIKALIVEHMSAIEKHSGRFNNLKLHLQSEVIHHWQFCWQ-----RCFNFYG---RKVQQEILFNLIDRNYDKPIIVHGDSGCGKTAFLAKVSTVIQEKFFNTTGENKSETNENSNGFQLNQTPVIVLRFIGTSMYSSSLHQLLFSVCFQIQLAYKLKVKFRKMTSLSSLKWLFNYLIQQISH--YSYQQSP---LIIIFDSIDQLFMFSNTLNESLSNSLDWIPVPLPPGIHIIISLITENFESKCFQMFQNRLSEFQHKFIHINYFDDKEVVLICQSLLEHKKRTLTDLQMNLIISKLINNPRGLYIKLALEQAVTWKS--YMSMEECIIKDCVE-SAVNFKFACLEEKYGLLLMSHALGYLTLGYNGLTEIELEDLLSLQDNVLNEVYQYHDPPI---SGIIRLPSLMCSRIHSDLSEYIIKKQTDDKVTLYWYHKQIHQCALKRYVKDLEILEILHKEMADYYAI-CGNIEKTCFLQNHKRKLEIKNADRLINNPPINEK-----------EPRKLHALSFHLVESRQNYELSKLCTANLKFLLSYAKCFGVQELI 893

[Close]

BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 92.0485 bits (227), Expect = 3.997e-18
Identity = 189/904 (20.91%), Postives = 363/904 (40.15%), Query Frame = 1

Query:   25 NLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNC-PIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQ--QEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSE--AHHQIYIDQFEAFITAKV----------VEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFAR--TIFE---FQSSLPHDSECH-------------FITRFVTSN---CTIAEIFLSIFLQISAIILRNNQFE--TILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC---SEVGSQSLVT--DLIPKFLPKNLKLIVS-STDSFDTRKPYFLNVLVPEFTQT----------EFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLN--RWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELSVILVDVIKDGYLLV----------DLATTVSVESLIDDKNSHLKDFHQILAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRKFRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELL 2532
            N ++   + FT   +     +  F+ S+F DF++ER +   ++ P L   C +++G+ ++L D++ G+  Y       + +    L +  +C K +  P F  L+G +YG    P  +P+  F+++ + + ++   F  E   + +++  DVN   P   L+ I+   P  Y    + II  +   EW K +  +    +   KI +S G    E   K+  +  E  F   +    D  F  VI  ++      +    N   ++ +     K ID     N +++     Q++L ++ NS  ++      KF + W  + G+++    H+ Y+D     +   +          +E  + R   + L L +  +  +            F  +G     +   +L  L D + + PII++G    GK+   A+  T+ +   F ++  + SE +              + RF+ ++    ++ ++  S+  QI        +F   T L + K + N + + I     S+QQ      III    ++    S   ++SL    D IP  LP  + +I+S  T++F+++        + EF             E  +  Q+ L +  + LT+ Q    +S  +    G+     +      ++  Y SMEE   +   E  A+N       +++G  L+SH L Y+     GLT+ E+ ++L+L   V+NEVY  H   +     I++ P  +   I  +LS  ++    D  + +           L   V    +++  +  + D++ I  G        Q      ++KN +   N  P ++K             RK   L  HLV      EL K    +  +L +  K   V EL+
Sbjct:   36 NKILSGCINFTDIGVSPPREVRIFLSSTFSDFKVERNLFIKQVIPSLHSIC-NDYGLSLRLCDMRWGVTDYAVNEHLVESLC---LKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDN---FPKEAELISKWFQKDVNSEPPVYNLLPIKTFIPK-YGDYEDEIIRRESGHEWWKVEENIRRCLKKSFKIAISQGLFTNEQKRKLIKSVTETEFWTAV---MDDNF--VINKQKASRCLAYERQINGLMNNLQSECAIKYIDYVTRDN-EIICESSAQNLLLEFKNSIKKVELRHFRKFNVPWVSN-GITDLLISHKNYLDDLSTTVICDIKALIVEHMSAIEKHSGRFNNLKLHLQSEVIHHWQFCWQ-----RCFNFYG---RKVQQEILFNLIDRNYDKPIIVHGDSGCGKTAFLAKVSTVIQEKFFNTTGENKSETNENSNGFQLNQTPVIVLRFIGTSMYSSSLHQLLFSVCFQIQLAYKLKVKFRKMTSLSSLKWLFNYLIQQISH--YSYQQSP---LIIIFDSIDQLFMFSNTLNESLSNSLDWIPVPLPPGIHIIISLITENFESKCFQMFQNRLSEFQHKFIHINYFDDKEVVLICQSLLEHKKRTLTDLQMNLIISKLINNPRGLYIKLALEQAVTWKS--YMSMEECIIKDCVE-SAVNFKFACLEEKYGLLLMSHALGYLTLGYNGLTEIELEDLLSLQDNVLNEVYQYHDPPI---SGIIRLPSLMCSRIHSDLSEYIIKKQTDDKVTLYWYHKQIHQCALKRYVKDLEILEILHKEMADYYAI-CGNIEKTCFLQNHKRKLEIKNADRLINNPPINEK-----------EPRKLHALSFHLVESRQNYELSKLCTANLKFLLSYAKCFGVQELI 893

[Close]

BLAST of AAA domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 92.0485 bits (227), Expect = 3.998e-18
Identity = 163/764 (21.34%), Postives = 317/764 (41.49%), Query Frame = 1

Query:   25 NLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFPKLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKYNC-PIF--LLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYYVLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQ--QEWKKTKSILSNLFQNLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREIIDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYYNSCNEIYEASEPKFRILWRDDTGVSE--AHHQIYIDQFEAFITAKV----------VEGVAERAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTDDDTNVPIILYGPPNSGKSIVFAR--TIFE---FQSSLPHDSECH-------------FITRFVTSN---CTIAEIFLSIFLQISAIILRNNQFE--TILKNSKEIENNIPRDIEGILLSFQQQSNKKFIIILHDFEKC---SEVGSQSLVT--DLIPKFLPKNLKLIVS-STDSFDTRKPYFLNVLVPEFTQT----------EFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGILTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLN--RWYKRFGKTLISHCLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPLSLWLLIKQELS 2142
            N ++   + FT   +     +  F+ S+F DF++ER +   ++ P L   C +++G+ ++L D++ G+  Y       + +    L +  +C K +  P F  L+G +YG    P  +P+  F+++ + + ++   F  E   + +++  DVN   P   L+ I+   P  Y    + II  +   EW K +  +    +   KI +S G    E   K+  +  E  F   +    D  F  VI  ++      +    N   ++ +     K ID     N +++     Q++L ++ NS  ++      KF + W  + G+++    H+ Y+D     +   +          +E  + R   + L L +  +  +            F  +G     +   +L  L D + + PII++G    GK+   A+  T+ +   F ++  + SE +              + RF+ ++    ++ ++  S+  QI        +F   T L + K + N + + I     S+QQ      III    ++    S   ++SL    D IP  LP  + +I+S  T++F+++        + EF             E  +  Q+ L +  + LT+ Q    +S  +    G+     +      ++  Y SMEE   +   E  A+N       +++G  L+SH L Y+     GLT+ E+ ++L+L   V+NEVY  H   +     I++ P  +   I  +LS
Sbjct:   36 NKILSGCINFTDIGVSPPREVRIFLSSTFSDFKVERNLFIKQVIPSLHSIC-NDYGLSLRLCDMRWGVTDYAVNEHLVESLC---LKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDN---FPKEAELISKWFQKDVNSEPPVYNLLPIKTFIPK-YGDYEDEIIRRESGHEWWKVEENIRRCLKKSFKIAISQGLFTNEQKRKLIKSVTETEFWTAV---MDDNF--VINKQKASRCLAYERQINGLMNNLQSECAIKYIDYVTRDN-EIICESSAQNLLLEFKNSIKKVELRHFRKFNVPWVSN-GITDLLISHKNYLDDLSTTVICDIKALIVEHMSAIEKHSGRFNNLKLHLQSEVIHHWQFCWQ-----RCFNFYG---RKVQQEILFNLIDRNYDKPIIVHGDSGCGKTAFLAKVSTVIQEKFFNTTGENKSETNENSNGFQLNQTPVIVLRFIGTSMYSSSLHQLLFSVCFQIQLAYKLKVKFRKMTSLSSLKWLFNYLIQQISH--YSYQQSP---LIIIFDSIDQLFMFSNTLNESLSNSLDWIPVPLPPGIHIIISLITENFESKCFQMFQNRLSEFQHKFIHINYFDDKEVVLICQSLLEHKKRTLTDLQMNLIISKLINNPRGLYIKLALEQAVTWKS--YMSMEECIIKDCVE-SAVNFKFACLEEKYGLLLMSHALGYLTLGYNGLTEIELEDLLSLQDNVLNEVYQYHDPPI---SGIIRLPSLMCSRIHSDLS 765

The following BLAST results are available for this feature:

BLAST of AAA domain-containing protein vs. Ensembl Human
BLAST of AAA domain-containing protein vs. Ensembl Celegans
BLAST of AAA domain-containing protein vs. Ensembl Fly
BLAST of AAA domain-containing protein vs. Ensembl Zebrafish
BLAST of AAA domain-containing protein vs. Ensembl Xenopus
BLAST of AAA domain-containing protein vs. Ensembl Mouse
BLAST of AAA domain-containing protein vs. UniProt/SwissProt
BLAST of AAA domain-containing protein vs. TrEMBL
BLAST of AAA domain-containing protein vs. Ensembl Cavefish
BLAST of AAA domain-containing protein vs. Ensembl Sea Lamprey
BLAST of AAA domain-containing protein vs. Ensembl Yeast
BLAST of AAA domain-containing protein vs. Ensembl Nematostella
BLAST of AAA domain-containing protein vs. Ensembl Medaka
BLAST of AAA domain-containing protein vs. Planmine SMEST

BLAST of AAA domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NWD2	2.557e-34	21.61	NACHT and WD repeat domain containing 2 [Source:HG...	[more]
NWD1	2.429e-17	23.67	NACHT and WD repeat domain containing 1 [Source:HG...	[more]
NWD1	2.629e-17	23.67	NACHT and WD repeat domain containing 1 [Source:HG...	[more]
NWD1	2.629e-17	23.67	NACHT and WD repeat domain containing 1 [Source:HG...	[more]
NWD1	2.629e-17	23.67	NACHT and WD repeat domain containing 1 [Source:HG...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
T05C3.2	3.226e-51	23.09	pep chromosome:WBcel235:V:5493747:5503010:1 gene:W...	[more]
qui-1	1.391e-6	21.84	QUInine non-avoider [Source:UniProtKB/TrEMBL;Acc:...	[more]
qui-1	1.993e-6	21.84	QUInine non-avoider [Source:UniProtKB/TrEMBL;Acc:...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CG10185	1.838e-35	23.17	gene:FBgn0038397 transcript:FBtr0083235	[more]

BLAST of AAA domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nwd1	4.259e-36	23.63	NACHT and WD repeat domain containing 1 [Source:ZF...	[more]
nwd2	2.238e-17	24.80	NACHT and WD repeat domain containing 2 [Source:ZF...	[more]
CU570791.3	3.164e-9	23.04	NACHT and WD repeat domain-containing protein 2-li...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
hsp90ab1	7.188e-32	21.45	heat shock protein 90kDa alpha family class B memb...	[more]
ppp1r3c.1	1.286e-20	21.89	protein phosphatase 1, regulatory (inhibitor) subu...	[more]
ENSXETT00000003639.1	3.655e-9	23.77	uncharacterized LOC101730828 [Source:NCBI gene;Acc...	[more]
ENSXETT00000022477.1	1.505e-6	20.77	pep primary_assembly:Xenopus_tropicalis_v9.1:KV460...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Nwd2	4.271e-37	22.90	NACHT and WD repeat domain containing 2 [Source:MG...	[more]
Nwd1	1.307e-16	23.81	NACHT and WD repeat domain containing 1 [Source:MG...	[more]
Nwd1	1.341e-16	24.34	NACHT and WD repeat domain containing 1 [Source:MG...	[more]
Nwd1	1.398e-16	23.81	NACHT and WD repeat domain containing 1 [Source:MG...	[more]

BLAST of AAA domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4


Match Name	E-value	Identity	Description
sp\|Q6P5U7\|NWD2_MOUSE	2.988e-36	22.90	NACHT and WD repeat domain-containing protein 2 OS...	[more]
sp\|Q9ULI1\|NWD2_HUMAN	1.228e-33	21.61	NACHT and WD repeat domain-containing protein 2 OS...	[more]
sp\|Q149M9\|NWD1_HUMAN	1.394e-16	23.67	NACHT domain- and WD repeat-containing protein 1 O...	[more]
sp\|A6H603\|NWD1_MOUSE	9.377e-16	24.34	NACHT domain- and WD repeat-containing protein 1 O...	[more]

BLAST of AAA domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267EA39	0.000e+0	29.01	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A267FKI0	0.000e+0	28.87	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A267G6I1	0.000e+0	28.87	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8JLX6	5.433e-179	26.72	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1S3JCC0	1.142e-127	24.25	NACHT and WD repeat domain-containing protein 2 OS...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nwd1	1.722e-35	22.23	NACHT and WD repeat domain containing 1 [Source:ZF...	[more]
nwd1	5.705e-23	22.99	NACHT and WD repeat domain containing 1 [Source:ZF...	[more]
nwd2	1.334e-16	24.92	NACHT and WD repeat domain containing 2 [Source:NC...	[more]
nwd2	1.446e-16	24.92	NACHT and WD repeat domain containing 2 [Source:NC...	[more]
nwd2	1.521e-16	24.92	NACHT and WD repeat domain containing 2 [Source:NC...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of AAA domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of AAA domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO31117	3.991e-38	21.67	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37261	4.423e-15	20.11	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40517	8.329e-11	21.69	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34994	1.198e-9	22.22	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47108	1.425e-9	22.92	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of AAA domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
nwd2	6.358e-20	22.51	NACHT and WD repeat domain containing 2 [Source:NC...	[more]
nwd2	6.358e-20	22.51	NACHT and WD repeat domain containing 2 [Source:NC...	[more]
nwd2	7.525e-20	22.41	NACHT and WD repeat domain containing 2 [Source:NC...	[more]
nwd1	1.849e-17	20.95	NACHT and WD repeat domain containing 1 [Source:ZF...	[more]

BLAST of AAA domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000012845.1	0.000e+0	99.26	SMESG000012845.1	[more]
SMESG000074035.1	1.943e-18	21.34	SMESG000074035.1	[more]
SMESG000074035.1	3.822e-18	20.91	SMESG000074035.1	[more]
SMESG000074035.1	3.997e-18	20.91	SMESG000074035.1	[more]
SMESG000074035.1	3.998e-18	21.34	SMESG000074035.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30003935 ID=SMED30003935|Name=AAA domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=5304bp
TAGAATTTCATGGAAAGTTTTCAGAATTTACTCATCAAAACCAGTTTGCC
TTTTACCGCCGCCAGTTTACCAGAAAGAAATGTCATCAATTTTTTTGTCT
GCTCATCTTTTGAAGATTTTGAAATCGAAAGAAAAATCTTGAACAATCGA
ATATTTCCAAAACTTCAGGAGCAGTGTTTTGATGAGTTTGGAATTGAAAT
TAAGTTGATAGACATTAAATTGGGTTTGGATTCGTACCTTGAGACCACTG
CGGCTTACCAGCAAATCTTCTACGAATATCTCAATAAACATGGAATTTGC
GATAAATATAACTGCCCAATTTTTTTACTTGGCCAAAAATACGGAAATGT
TCTGCCTCCCCTTCGGATACCAACAAAAATTTTCAAACTCCTTTTAGAAA
CATTGAAAAATCATAAGAAACGGTTCGCTGTTGAGGGAAATTTTCTGGAG
CAATATTATGTCTTGGATGTAAATTGTGTTGAACCAGAAATGATTCTGGT
TGACATTCAAGCTATTTATCCTGATTTATATAAACAAGATAGAAATTCTA
TAATTATTTGTCAACAAGAATGGAAAAAGACTAAATCTATTTTATCAAAT
TTGTTTCAAAATCTGTCAAAGATCTGCTTGTCTAATGGTACCCTCGATGT
TGAAATGGTCACAAAAATCTTTGTGAATGAATTCGAAGCGACCTTTTCAG
AAACAATAAGGAAAAGTTTTGACTCCAAGTTTTCTCCTGTAATTTTCAAT
CGTGAAATTATTGATATAAAGAATTTCATCGTGATTTCCAACCAAAAGAA
AGATGATAAACGAAAATCTGCCATTGAAAAGCTGATTGATGTAACCTACA
GTCAGAACGCGGATTTAGTAATAAATGAAGATTTACAAAGCGTTTTGAGG
CAATACTATAATTCTTGCAACGAAATCTATGAAGCTAGTGAACCGAAATT
TAGAATCCTCTGGAGAGATGACACTGGGGTCTCTGAAGCACATCATCAAA
TATATATTGATCAATTTGAAGCCTTTATCACCGCCAAAGTCGTTGAAGGA
GTTGCTGAAAGAGCAAAGAAAATCAATTTAGACTTGTCCGCGAGTTTCTT
AAAATGTTATGACATAATTTGCAATGCAGATCTGCAAATAAATAAATTTG
CAAAGTTTGGTTGCGGGTATGAGGACATAGTTTACGCGATGTTGGATTAC
TTAACCGATGACGATACCAATGTCCCAATTATTTTATACGGTCCCCCTAA
TTCTGGAAAGTCAATAGTATTTGCTCGAACGATATTTGAGTTCCAAAGCT
CCCTACCACATGACTCTGAATGCCATTTTATCACTCGGTTTGTCACATCA
AATTGTACAATTGCTGAAATTTTCTTGAGTATATTTTTACAAATTAGCGC
AATTATTTTGAGAAATAATCAGTTTGAAACGATTTTAAAAAATTCCAAAG
AAATCGAAAACAACATTCCGAGAGACATTGAAGGAATCCTGCTCAGTTTC
CAACAGCAGTCGAATAAGAAATTCATCATCATTCTCCATGATTTCGAAAA
GTGCTCTGAGGTCGGTTCTCAGTCGCTTGTCACAGATTTGATTCCGAAGT
TCCTACCGAAAAACCTGAAACTTATTGTGAGTAGTACCGATAGCTTTGAC
ACCCGGAAACCGTATTTCCTTAATGTTCTCGTGCCGGAATTTACTCAGAC
TGAGTTTAATATTTTTATTCAAACTCAACTAAACAACACTGGAAAACTTT
TAACCGAAGAACAAAACGAAAGGTTTTTATCAAATTATCTAAAATTTACA
GATGGAATTCTCACTGCATCAGTCATTGTTGACTATTTTTATAATCAGAA
CTTTATATACAATTCTATGGAGGAAATACCCTGTCAAACTCTCGGAGAGT
TTTATGCTCTCAATCTCAACAGATGGTACAAAAGGTTTGGAAAGACACTG
ATTTCCCATTGTCTTCTTTACATATATTGTTCATCCGGAGGCTTGACGGA
TCAGGAAGTCATTGAAGTTCTGAATTTAGATAAAAAAGTCATGAATGAGG
TTTATATCAATCACTCAGAATCCCTCATTTATGATCAAAGTATTGTCAAA
TTTCCTTTGTCTTTATGGTTGTTAATTAAGCAGGAATTGTCAGTCATATT
GGTGGATGTGATTAAAGATGGATATTTACTAGTAGATTTGGCTACAACGG
TTTCTGTAGAGTCTTTAATTGATGATAAAAACAGCCATTTAAAGGATTTC
CATCAAATTCTGGCCGGTTACTTTAACGGAGCATGGGTAGATCAAACCAT
TTCTTTTCATTTTGATCTGAAAAACCCAGAAATGTCATACAACTGCTGTC
CGAAAAGTCAGAAAATGTACGCTAAAAAGAGTGGAAATGTATTTTATAAC
TACCGAAAATTTCGACAACTCGTTCGGCATTTGGTGGCAATTGATAATTA
TGATGAGTTGATAAAGAATGTCATTTTTGATTTTGATTATTTGTACAATA
AAACAAAAGCTCTCAAAGTTTCGGAATTGTTAGATGACTTCCAACTGGCC
CGAAACGGCGGAAAGGAAATTGTTCTGCTAGAGGAAAGCATCAACAATTC
TGCCTTAGTGATAGAGAATGATCTCGACAGTCTTGCGGGAGAATTAATTA
TGCAATTGTTACCCTACGTTTCCTATTATCCAAATCTGAGATTTCTCATA
GAAAATTGTGATAAAGTCGCTCCTAAGCACAATGCATTCGTCCCGATTTA
TCCTTCCAATAAGTTGCCAGGGTCTCCACTGGCCAGCACTATCAATTGTC
CGGAGGCTATTGAATCTGTTTTGGTGATTCAAAATAAAGAAAGCATGAAT
AAAGAGCTTTTAATTAAACTAAAAAACGATTCCAGAGCGTATTTCTATGA
TTTATCATTCGGAGCGATATCTTATAATACACTACTAAGCAGCGGGGAGG
TTTATTATGGACCAAATAGGGACATCATTCTTGTATTAGAAACCGAATAC
CGACAAATCATCAAGGTTCATCAAAGAGAAACTGGTGATTTGCTTGGTCA
AATAATACCCATGAATTGGGTGGTACTTCGACCTTTTGAGGAAAGAAATG
AATACAGAATAACTAACATTGACATGAATCAAACTAAGATGGCACTAATC
ATAACAAATGAAGTGAGTTATTTATTCGTTTTGAATTTGGAAACCCTAGA
ACCAATACTGGCCTTTAATCCAGGGTTGCGATTAGAAATGCTAAAGCTGA
CACCAGATGAGTCGACAGTTTTTACTCATCACGTTGAAAGGCTCGTGAGT
TTAAACGTGGAAAAGAACCAACTGAATTCAGCAGTTGAACTTCAAGGTAT
ACCTCTGCAAATGTTATTTGCCAATGAACAATCGAAAAAAGCTTTTATCG
TTTGTGATCAACAGAAGAGTGTTGTAGTTTTGGATCTTGAATCCGCGGGC
GTTGTGAGGAAATGTTATAAAATATCTTTTGAAAACTGTCTTGATGAAAA
TGATTATGTTTTAGAGGTTTCGTGTTCGGAAATCGGTAATCCATTTCTCT
TGATCATGTCTTGTCACAGTGTTATTTTGTATGACTGGAATAAGGAAAAG
GTGCTCAATCATATTACCCGTCCTTCACAGCTACCGGTTTATTTCAAGCT
ACCCAATCGGCTGGATAACCAACCGGCAAGTCTGAAATTCAATGCTGCCA
AACTGATTTTGTCTGACCGAGTTATTATCTGTGCGCTGTTTCGAGACGTC
ATTGTCTGCACAGTCTCTGACAATAAAATCATTAAGACTCTCCATGCACC
TGTCGGAGGCATCGTTTCTGAAATCCACATTGCCGATGATTATATCATTG
GAAAAGTGGAACAAAGTCAAAATTCGGCGGAAGTCATGATTTGGAAAACG
GATCCAAAGTGTTTGTTTTTCAAAATAGAAAACAATCAAGATAAACTGAC
AAGATGCGTTAAGAAAATACAAATCGGTGGCTCTGTAGCAATTGCTTCGT
GTGTTGAAAGTGACGAAATGGGAGTAATAGAAATATCAACCGGAACATTG
GTCGACCTTTATAGTCACTCGTCTGTGGTGATTAATTGTTGCTTGTCATC
GTGCGGAAAATGGGCTTTGGTCACGGTGAAGAATTCTCACAATGCCAATA
TTCTCTGGTCTTTGGAAACCCGAAAAATCATTTTCGAATTCGGATCATCA
ACCAACACGGAATTTATTGTTCCAATGAAATCGAAATCAGGATTTTACTG
CATTACAAACCATTCAAAAAGTATCGATGCACCGAATTTTATCGTCACTC
AAATCCTCTGTGATCTGGGTGTTGAAATATCATATACCATAAAGGTTTTA
GAAATTTCTTGTTTAGGATTCCTTACGGAACCTCCTTGCATTTTGAATGA
TGATAAAGAGTTAGCGTTTCTTTCCAGCAACTACCGCACTGAAAATGGAG
TAGGGACTGGTACAAACAGTCTGATTTTGTGGTCAAGAGAAACTCATACG
AATCAAAACGGGATGTCAAAGATAATTACGGTGAAAGAGTTTTCAGAACA
AATTAATAGGTCTGTTGAAGATATATTGTCGATCACAACTACAAAGTCAA
TGGAGGATGTTTTATTTATCTTTTTCAAGACTCATGACCATGAGATTGAT
ATTTTACATTTCAATTGTCATACAGGTCTAGTTATTCAATTCATGGAATT
GTTCGATGTCCTTCCTAAGCAAATGGACCACAAAGAATTGTTCTTGTCTA
ACAACGGTTGCTATGTGTTCTATCAAAAAACTAGCGCCATAGTCAACTTG
TCTAGTGGAGAATTTATTGGAAATATTTCTTCTGATGCTAATAATGAGTA
TGCATTTCAGTGTTTCGTTTTAAAGGATACAATTTTGATTTTGTCACAAA
AAACGAAATTACTTGCATATCGTTTGCCGGAAATCTGCAAAATCGGTCAA
ATTGAATTGAAAGACGAGGTGTCTTGCGTTTCTAAATGTCTTGATGATTT
CACAATAATGGTGGGTTGCGTTGACGGATCAGTATTATCGTATTCGCTCA
TTGATATATTTTCTCCATACAGTTTTCTCAGCCAGATTAAAGTTGTGAGA
AATTTCTTGCCGACAACCAGAAGCCCAACAATAGAACTGGAATCGATACG
GTCGCTGAACAAAACCGAATTATCCCAAGAGTTTGACAACCTTATAGCCA
TCAAGCGGCCGATATCCGAGCCCATAGTTGCTCATGAAAGACGAGAATTT
TCTAATATTTATTAATTTAAATATGGTGAAATTTTTATTATGTTAATAGA
TGAA

protein sequence of SMED30003935-orf-1

>SMED30003935-orf-1 ID=SMED30003935-orf-1|Name=SMED30003935-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1752bp
MESFQNLLIKTSLPFTAASLPERNVINFFVCSSFEDFEIERKILNNRIFP
KLQEQCFDEFGIEIKLIDIKLGLDSYLETTAAYQQIFYEYLNKHGICDKY
NCPIFLLGQKYGNVLPPLRIPTKIFKLLLETLKNHKKRFAVEGNFLEQYY
VLDVNCVEPEMILVDIQAIYPDLYKQDRNSIIICQQEWKKTKSILSNLFQ
NLSKICLSNGTLDVEMVTKIFVNEFEATFSETIRKSFDSKFSPVIFNREI
IDIKNFIVISNQKKDDKRKSAIEKLIDVTYSQNADLVINEDLQSVLRQYY
NSCNEIYEASEPKFRILWRDDTGVSEAHHQIYIDQFEAFITAKVVEGVAE
RAKKINLDLSASFLKCYDIICNADLQINKFAKFGCGYEDIVYAMLDYLTD
DDTNVPIILYGPPNSGKSIVFARTIFEFQSSLPHDSECHFITRFVTSNCT
IAEIFLSIFLQISAIILRNNQFETILKNSKEIENNIPRDIEGILLSFQQQ
SNKKFIIILHDFEKCSEVGSQSLVTDLIPKFLPKNLKLIVSSTDSFDTRK
PYFLNVLVPEFTQTEFNIFIQTQLNNTGKLLTEEQNERFLSNYLKFTDGI
LTASVIVDYFYNQNFIYNSMEEIPCQTLGEFYALNLNRWYKRFGKTLISH
CLLYIYCSSGGLTDQEVIEVLNLDKKVMNEVYINHSESLIYDQSIVKFPL
SLWLLIKQELSVILVDVIKDGYLLVDLATTVSVESLIDDKNSHLKDFHQI
LAGYFNGAWVDQTISFHFDLKNPEMSYNCCPKSQKMYAKKSGNVFYNYRK
FRQLVRHLVAIDNYDELIKNVIFDFDYLYNKTKALKVSELLDDFQLARNG
GKEIVLLEESINNSALVIENDLDSLAGELIMQLLPYVSYYPNLRFLIENC
DKVAPKHNAFVPIYPSNKLPGSPLASTINCPEAIESVLVIQNKESMNKEL
LIKLKNDSRAYFYDLSFGAISYNTLLSSGEVYYGPNRDIILVLETEYRQI
IKVHQRETGDLLGQIIPMNWVVLRPFEERNEYRITNIDMNQTKMALIITN
EVSYLFVLNLETLEPILAFNPGLRLEMLKLTPDESTVFTHHVERLVSLNV
EKNQLNSAVELQGIPLQMLFANEQSKKAFIVCDQQKSVVVLDLESAGVVR
KCYKISFENCLDENDYVLEVSCSEIGNPFLLIMSCHSVILYDWNKEKVLN
HITRPSQLPVYFKLPNRLDNQPASLKFNAAKLILSDRVIICALFRDVIVC
TVSDNKIIKTLHAPVGGIVSEIHIADDYIIGKVEQSQNSAEVMIWKTDPK
CLFFKIENNQDKLTRCVKKIQIGGSVAIASCVESDEMGVIEISTGTLVDL
YSHSSVVINCCLSSCGKWALVTVKNSHNANILWSLETRKIIFEFGSSTNT
EFIVPMKSKSGFYCITNHSKSIDAPNFIVTQILCDLGVEISYTIKVLEIS
CLGFLTEPPCILNDDKELAFLSSNYRTENGVGTGTNSLILWSRETHTNQN
GMSKIITVKEFSEQINRSVEDILSITTTKSMEDVLFIFFKTHDHEIDILH
FNCHTGLVIQFMELFDVLPKQMDHKELFLSNNGCYVFYQKTSAIVNLSSG
EFIGNISSDANNEYAFQCFVLKDTILILSQKTKLLAYRLPEICKIGQIEL
KDEVSCVSKCLDDFTIMVGCVDGSVLSYSLIDIFSPYSFLSQIKVVRNFL
PTTRSPTIELESIRSLNKTELSQEFDNLIAIKRPISEPIVAHERREFSNI
Y*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000054	dorsal region of the epidermis
PLANA:0000096	ventral epidermis
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR015943	WD40/YVTN_repeat-like_dom_sf
IPR027417	P-loop_NTPase

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0003674	molecular_function

Vocabulary: **cellular component**
Term	Definition
GO:0005575	cellular_component

Vocabulary: **biological process**
Term	Definition
GO:0008150	biological_process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 387..551 e-value: 1.4E-7 score: 33.4
None	No IPR available	PANTHER	PTHR19871	BETA TRANSDUCIN-RELATED PROTEIN	coord: 29..924
None	No IPR available	CDD	cd18078	DEXXQc_Mov10L1	coord: 393..434 e-value: 0.00373817 score: 38.8891
None	No IPR available	SUPERFAMILY	SSF69322	Tricorn protease domain 2	coord: 1046..1395
None	No IPR available	SUPERFAMILY	SSF69322	Tricorn protease domain 2	coord: 1330..1680
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 384..609

Main menu

AAA domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

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