FMRFamide-activated amiloride-sensitive sodium channel
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003924 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1) HSP 1 Score: 66.2402 bits (160), Expect = 4.632e-10 Identity = 108/534 (20.22%), Postives = 211/534 (39.51%), Query Frame = 2 Query: 128 EFFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVE--YFQNKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGY-NITRHSSPDFFNCYTINVKPEYSLNT----EYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANF-------RNMSDEDFKEFWKRGRCI-----------SETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQL---EWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFL--NAKDINELISEN-----------ENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLT 1606 E + + G+AK+ S K++W + + T + ++R+YL++ ++++ +P+++IC +P S R + YF N+ S +W LR K E+D F + +R +Y+NL +++ + N +++ + C RE C N + ++FNC+T N ++ + LI K L + + L+ G +++VH GS P I I P + P C T + + +Y +TF CL K + ++++C C + LP +PS +C RN S+ED + + I + L D+ E + C++ C + +S W +QL E FK ++ +EK + + L N +++++S++ + + +++ + LE LS + + GL+ L + IGG+ L++G++ Sbjct: 45 ELGSESNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPISLRTIRRMYFNNE--SQNLITW-LRFIQKFRFEQDS--------FMNSIRAFYENLG-QDAKKLSHNLEDMLMHCRFN----------RELCHVSNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNILHSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNC------TNDMLNGIKQYKYTFFACLQLCKQRLIIQRCGCKSSALPE--VPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYE-LSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLA--DLFADIGGTLGLWMGIS 545
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A1I8H6N9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002809g2 PE=3 SV=1) HSP 1 Score: 246.899 bits (629), Expect = 2.199e-69 Identity = 172/535 (32.15%), Postives = 270/535 (50.47%), Query Frame = 2 Query: 131 FFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNK-GMSPKEFSWKLR-------------------------KSAKRYLEKDQPHIAESI------LFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITR---HSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLS-ESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCIS--ETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLID--FPKNRSIVEKAKADALRFL---NAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLT 1606 F SIRGV KV+K+ S ++ MW IF+ + L YS+ KI +YL+Y+ IQT +++D +PFPA++IC QPFS A + + NK MSP EF+ LR K +K + + Q S+ L YD+LR+YYQN+ +E+ +G E V CI K G G C ++ + S P+FFNC ++ PEY++ I LI+ + +I + S L + G ++ VHE + P + I EP ++ +I Y ++ TP + C+S ++ +K DL EY++ F+ CL+S + VL KC C+ LPR+ +P++ +PYC DE FKE R +C+ + T K E K+C+ C+ F ++S KW T W L W+ +L + W+ N S E++ +L N D+ L + + F D++++ +V++R SN TF K EK+ L+L L SR+GG C++Y+GLT Sbjct: 9 FLETSSIRGVGKVFKTQSPLLSRMWGIFVLGSTSFLFYSVFKITLDYLQYDVNIQTYQEIDDETPFPAVSICNNQPFSVNAYQRWSNKQSMSPTEFNKYLRQQALSLVSPDLMRDKYRDLQAARDRKDSKAFRQIHQSMFDSSVAAMTYSLIYDNLRMYYQNMLADEAMELGHTRNESIVDCIFKYGSIQVLGT--RGCHDDMVKVKTFSDPNFFNCLSVEFTPEYAMTIISITLIVWLGPDDSYDIRHRQSFLNEVYEQAYGLRVDVHEPKTQPRVLEQGIQTEPGKMNEIKYQPIRFERKDTPKNPCISLDAAEKQKFRDLRMEYNYDFELCLNSKVQEVVLNKCGCMYIELPRIAMPNKTHPYCG----FMDEKFKE---RSQCVKSLDMRTIRKSFEG--KDCFPKCVDLSFEKELSTTKWRETKWMLHWIKELCERWDKQFKQLSGSNASEFEESLTGVTDYLTRDNITDLRSLGNSTSKASFDFDDRFSFIVVKRQSNNTFVKTEKIVLTLNALFSRVGGLCSMYIGLT 532
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A183TB06 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS13654 PE=3 SV=1) HSP 1 Score: 229.95 bits (585), Expect = 2.238e-63 Identity = 159/524 (30.34%), Postives = 260/524 (49.62%), Query Frame = 2 Query: 131 FFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKG-MSPKEFSWKLRKSAKRYLEK---------------DQPHIAESI---LFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLG-IGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRN----MSDEDFKEFWKRGRC----ISETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISE--NENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCA 1612 F + SIRG ++ KS ++ ++++W +++ + L SI+K++ EY+EY+ IQT + ++ + FPA+T C +QPFS A E ++ K MSP F+ LR A + LEK + I E++ L YD L IYYQ+L + + +G K++ V C+ + G M G + I S P +FNCY++ + S + + LIL KN + + L L +G ++++HE G R + P R+ ++ + ++ PN C + S +++ DLD EY + F+ CL S V+++C C+ A+ PR+ P+ PYC + DED +R +C IS K++E K C + C+ ++ Q+S W PT WQL W Q + L D N S+ FL K++ ++ NE + F D+++A +V++R SN+T K E L L+ L SRIGG C+LY+G+T A Sbjct: 30 FLESTSIRGCNRIVKSENRALRVLWTVYVCLTTLFLHISIMKLVNEYMEYSVNIQTYINMDAPTAFPAVTFCNHQPFSSSAYELWKRKKIMSPTTFNQMLRNRASKILEKAIKIPEGPLANIQLINASLIQEALVQGLIYDTLPIYYQSLNWPDHRRLGHKSKDVLVLCLLRYGSTWMLTGPGCADPMLKIRHQSDPKYFNCYSVEIMKYASEHINELGLILWLGPDKNYGKEDRQAFLFDLFEQSVGLRVVIHEPGQRGSLDRHGFQVAPGRMNEVIFQTVKMIHFNRPNKPCFANS--SQRFNDLDEEYDYQFEMCLSSYIQNLVVQRCGCLYAYFPRIYPPNATLPYCGQLVAGEDVLLDEDL--IMRRRQCARLIISNAAVLRKKIEE-EKICLRRCVVTEYETQVSVTMWRPTSWQLYW----SQKTSSLFDSAINGSLTPDEAHLIYHFLKTKNLTNFSADESNEKNTFVFDDRFAYLVVKRKSNDTVVKNENLVLTQNALFSRIGGLCSLYIGMTFA 544
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A1I8G5D0 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 230.335 bits (586), Expect = 1.188e-60 Identity = 153/520 (29.42%), Postives = 257/520 (49.42%), Query Frame = 2 Query: 122 RKEFFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQ--NKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTIN-VKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKE-YSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLV-IPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMY-----------KNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKN-------RSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCA 1612 R+ F ++ S+RGV K+ ++++ ++I+W++F+ M LL+YS ++L Y EY+ ++QT + D S FPAITIC + PFS RA +Q + ++P F+ +LR+ ++ L +A ++LFYD + YYQNL + +G + E + C+ +G + G+ E C S P +FNCYT+ + + S ++LI+ ++ + + + G +LL+HE P +HIEP ++++I + WKE +P D C I DL N Y +++Q C ++ K + KCQC+++ PR +PS Q PYC +FR + R RC+ E ++ C K C R ++ ++S +W + +QL W+ SW L + R+I++ AD L L + + ++ YA VV+ R S +T +EEKL ++ L+SR+GG C+LYLGLT A Sbjct: 1323 RQLFCSSSSLRGVPKICRADTTFLRILWLVFVLAMFILLVYSSTRVLMNYREYDVSVQTSVIGNDPSDFPAITICSHYPFSPRAARMWQQCDGQLAPATFNRRLRQLTRQLLFSGNLRLANTLLFYDKVNTYYQNLDPNVTVSMGHSVDEFLLHCMIAIGNYVMVGKASE-CQLTFQLVSHPKYFNCYTVKPTQADKSQAMSAVYLIVNLGSNSRQHPWE-QAFVMDVFDQAYGLRLLLHEANLYPGIENAGVHIEPGKMVEIAFDTVLWKETQDSPMDRC--HDGWRPAIEDLQNRYRYSYQACKEAHMNKLFIAKCQCLLSRFPRPAGLPSNQIPYCGDFRT---SNISIIESRLRCLEEIGEHQSKMPQPAAAAAAAAVADDSQCRKRCTRYSYDQELSITRWRASSYQLHWMLHQSDSWKRLREVNNESEKRHLLRNILDYLGADNLTRLPVSYQQQERQQQATLTDSAEDTYAYVVVRRKSFDTLKREEKLTVTFEALMSRVGGLCSLYLGLTMA 1835
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A074ZXV4 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_01690 PE=3 SV=1) HSP 1 Score: 221.476 bits (563), Expect = 3.799e-60 Identity = 149/520 (28.65%), Postives = 267/520 (51.35%), Query Frame = 2 Query: 131 FFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKG-MSPKEFSWKLRKSAKRYLEKDQPHIAESIL--------FYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKL-GIGMFFGEVRENC---GYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYK---NCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRF----------LNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCA 1612 F + SIRG ++ ++ S I+++WI FL L+ S+ +I++EYL Y+ I+T+ +++ + FP++T C +QPFSE+A E +++ +SP +F+ LR+ A+ ++ + +I+E +L +D +++YYQNL + + +G + C+ + G + G C +I S P +NCYT+++ S + + LI+ P+N +I + + L+ + G ++ +HE G R I IEP R+ +IN+ + TP C+ + K ++ DLD EY + F+ CLDS + V+E+C CV A+LPR+VIP+ PYC + D + + R C+ + + +L ++ C + C +++ ++S W T WQL W Q++ N L + + KA D L NA D+ + + +++ ++++R N+T ++E L L+L LVSRIGG C+LY+G+T A Sbjct: 33 FLESISIRGCNRIVRAQSMFIRLLWICFLICTTVFLIVSVRRIVKEYLLYSVNIETEERMDAPTEFPSVTFCNHQPFSEKAYELWRSGSVISPTQFNRILRQKAEELVDNNSGNISEHLLQMVAHYSIVFDTIKMYYQNLDWPDQKRLGHQRNQSIYMCLIRFSGEELLLGG--PGCYDEMIHIKERSHPHHYNCYTVDINIYLSRRVQELGLIVWLGPPENYDIRYRQAFLQDVFEQAHGLRVAIHEPGQLVNLDRLGIQIEPGRMNEINFEVIRKEHQQTPRKPCIQDPK--DQYRDLDGEYDYEFELCLDSLIQQIVIERCSCVYAYLPRIVIPNATLPYCGRLLRNNQLDAQGLFDRKECVRHVVQQFAKLRKQFEAEGKCLRRCQTLEYDKRVSVTTWRATQWQLYW---SQETANALEEIMASSPNFTKASVDRLTVYLKTANLSTAFNAPDVTH---KGITRKYGFSDRHTYLLIKRKRNDTVVRKETLVLTLDALVSRIGGLCSLYIGMTFA 542
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: H2KTS4 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CLF_106033 PE=3 SV=1) HSP 1 Score: 220.705 bits (561), Expect = 8.691e-60 Identity = 154/541 (28.47%), Postives = 282/541 (52.13%), Query Frame = 2 Query: 131 FFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKG-MSPKEFSWKLRKSAKRYLEKDQPHIAESIL--------FYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKL-GIGMFFGEVRENC---GYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYK---NCYKSCIRQKFNLQISNIKWTPTLWQLEW-------LFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAXXXXXXXXXXVLWTEQSHKREIRK 1684 F + SIRG ++ ++ S I+++WI FL L+ S+ +I++EYL Y+ ++T+ +++ + FP++T C +QPFSE+A E +++ +SP +F+ LR+ A+ ++ + +I+E +L +D +++YYQNL + + +G + C+ + G + G C +I S P +NCYT+++ S + + LI+ P+N +I + + L+ + G ++ +HE G R I IEP R+ +IN+ + TP C+ + K + DLD EY + F+ CLDS + V+E+C CV A+LPR+V+P+ PYC + D + + R C+ + + +L ++ C + C +++ ++S W T WQL W L ++ S +R IV A+ NA D+ + + +++ ++++R N+T ++E L L+L LVSRIGG C+LY+G+T A FIE++EF +++ + SH ++ R+ Sbjct: 33 FLESISIRGCNRIVRAQSMFIRLLWICFLICTTVFLIVSVRRIVKEYLLYSVNLETEERMDAPTEFPSVTFCNHQPFSEKAYELWRSGSVISPTQFNRILRQKAEELVDNNSGNISEHLLQMVAHYSIVFDTIKMYYQNLDWPDQKRLGHQRNQSIYMCLIRFSGEELLLGG--PGCYDEMIHIKERSHPHHYNCYTVDINIYLSRRVQELGLIVWLGPPENYDIRYRQAFLQDVFEQAHGLRVAIHEPGQLVNLDRLGIQIEPGRMNEINFEVIRKEHQQTPRKPCIQDPK--NRYRDLDGEYDYEFELCLDSLIQQIVIERCSCVYAYLPRIVVPNATLPYCGRLLRNNQLDAQGLFDRKECVRHVVQQFAKLRKQFEAEGKCLRRCQTLEYDKRVSVTTWRATQWQLYWSQETANALEQIMASSPNFTQTSVDRLIVYLKTANLSTAFNAPDVAH---KGITRKYGFSDRHTYLLIKRKRNDTVVRKETLVLTLDALVSRIGGLCSLYIGMTFAIFIEVIEFFYMVYMKNSHSKKRRR 566
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000053391.1 (SMESG000053391.1) HSP 1 Score: 1003.05 bits (2592), Expect = 0.000e+0 Identity = 511/513 (99.61%), Postives = 511/513 (99.61%), Query Frame = 2 Query: 242 YSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAXXXXXXXXXXVLWTEQSHKREIRKEVEVDKIALNQPPIGPCRDMAIVSEDDFNNIQ 1780 YSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQKISLLKSLSLNIIGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAFFIEILEFIIVLWTEQSHKREIRKEVEVDKIALNQPPIGPC DMAIVSEDD NNIQ Sbjct: 7 YSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQKISLLKSLSLNIIGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAFFIEILEFIIVLWTEQSHKREIRKEVEVDKIALNQPPIGPCSDMAIVSEDDINNIQ 519
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000053382.1 (SMESG000053382.1) HSP 1 Score: 689.878 bits (1779), Expect = 0.000e+0 Identity = 359/547 (65.63%), Postives = 446/547 (81.54%), Query Frame = 2 Query: 95 KIRNSGKFKRKEFFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAXXXXXXXXXXVLWTEQSHKREIRKEVEVDKIALNQPPIGPC 1735 K R + + FF NCSIRGVAK YK++S IIK++WIIF+ IMMTLLLYSI+KI+ EYLE+NTTIQT+LQLED+SPFPAITICPYQPFS+RA+ +F+NKGMSPK+FS+KLR++AK +LEKD P AESILFYDDLR+YYQNLKY +STYIGL++ E+FV+CI KL IGMF G+VR +CG+NI+R+SSPDFFNCYTIN++PEYS +TEY+HLIL+F KP NLE F++ SLLK+L ++IGAQ+ +HE GSSP ST+EKIH+EPNRLLQINY N WKE +TP D+C+ ESK EK+ DLDNEYSF+FQ CLDS KAK +LE+C CVMAFLPR +IPSE++PYCA+F+N+S+E F+ F K+G+CI + L +D+ L + K CYK C QKF+LQISNI W P LWQLEWL L QSWNVLI+ P N +IV AKA+AL+FLNA ++ +L +ENS F K+E YACV++ERLSNETFY EE+LGLS+YGLVSRIGGSCTLYLGLTCAFFIEI+E++I+LW Q +KI+ N P PC Sbjct: 4 KTRGNSVSNMEIFFTNCSIRGVAKAYKTSSLIIKLLWIIFIMIMMTLLLYSIIKIVIEYLEFNTTIQTRLQLEDSSPFPAITICPYQPFSDRAIRFFKNKGMSPKDFSFKLRRTAKSFLEKDSPKKAESILFYDDLRVYYQNLKYNDSTYIGLDESEIFVYCINKLRIGMFIGDVRSDCGFNISRYSSPDFFNCYTINIRPEYSRDTEYVHLILKFFKPTNLERFRETSLLKTLFQHVIGAQITIHETGSSPTSTKEKIHVEPNRLLQINYRNINWKEQNTPTDVCIQESKTLEKLIDLDNEYSFSFQSCLDSYKAKNLLERCHCVMAFLPRSIIPSERFPYCADFKNISEEGFEYFLKKGKCIVKVLNEDQRLTSSDKKCYKKCEEQKFSLQISNIVWEPNLWQLEWLLTLHQSWNVLIEPPANDTIVRSAKAEALKFLNANELKDLTDVHENSPFHKNESYACVIIERLSNETFYNEERLGLSMYGLVSRIGGSCTLYLGLTCAFFIEIIEYLIILWKRQCK----------EKISSNGP--NPC 538
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000053390.1 (SMESG000053390.1) HSP 1 Score: 657.136 bits (1694), Expect = 0.000e+0 Identity = 340/520 (65.38%), Postives = 424/520 (81.54%), Query Frame = 2 Query: 131 FFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQNKGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYKNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPKNRSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAXXXXXXXXXXVLW-TEQSHKREIRKE 1687 FF NCS+RGV+K YKS S IIK++W+IF+ +MM L+LYSI+KIL+EY+EYNTT+Q LQ EDAS FPAITICP+QPF +R++++F+NKGMSPK+FS KLRK AK +LEK P AE+ILFYD+LR YYQNLKY ESTYIGL +KE+FV+CITKL M GEV +NCGY I+R+SSPDFFNCYT+N++PEY NTEYI LILRFPKP NL + +IS L++LS N IGAQLL+HE GSSP ST+EKIHIEPNR+LQINY N YWKEYSTPND+CLS+ + KI DL+N Y+FTFQGCL+S AK++LEKCQC+MAF PR VIPSE++PYCA+F N+++E F+ F CI + L KD++L + K C+K C QKFNLQISNI W P+LWQLEWL+KLQ+SWN+LID P N ++ KAK A++FL+A + EL + +NS+F DE YACVVLERLSNET+YKEEKLGLS++GL+SRIG SCTLYLGLTCAFFIEILE++I+ W T + K E+ ++ Sbjct: 15 FFTNCSVRGVSKAYKSRSLIIKLLWLIFITVMMILMLYSIIKILKEYMEYNTTMQNVLQFEDASDFPAITICPHQPFFQRSIKFFKNKGMSPKDFSLKLRKVAKAFLEKQAPDKAENILFYDNLRSYYQNLKYNESTYIGLTEKEIFVYCITKLKHEMLLGEVEKNCGYVISRYSSPDFFNCYTLNMRPEYLKNTEYIQLILRFPKPHNLSQYMEISFLQTLSRNAIGAQLLIHESGSSPTSTKEKIHIEPNRILQINYRNVYWKEYSTPNDVCLSKKENLNKIIDLENNYTFTFQGCLESYIAKKILEKCQCIMAFFPRSVIPSEKFPYCADFHNITEEGFERFVLSTGCIRKVLNKDQKLSSSDKKCFKVCEEQKFNLQISNIYWEPSLWQLEWLYKLQKSWNILIDSPDNLTLANKAKTVAMKFLSATGLAELSTGYDNSLFNNDEMYACVVLERLSNETYYKEEKLGLSMHGLISRIGASCTLYLGLTCAFFIEILEYLILNWMTRNTGKNEVGRD 534
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000043119.1 (SMESG000043119.1) HSP 1 Score: 236.884 bits (603), Expect = 3.236e-69 Identity = 168/548 (30.66%), Postives = 288/548 (52.55%), Query Frame = 2 Query: 116 FKRKEFF----NNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYFQN-KGMSPKEFSWKLRKSAKRYLEKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCG----YNITRHSSPDFFNCYTIN-VKPEYSLNTEYIHLILRF-PKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMYK-NCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSWNVLIDFPK---NRSIVE-KAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCAXXXXXXXXXXVLWTEQSHKREIRKEVEVDKIAL 1711 F+ K FF + SIRG+ K+ K + + L + L+ S + ++R+++ Y+ I TKL+++ +PFPA+T+C + PFS R +++ K MSP F+ K+R L + AE+I +YD + IYYQNL YE++ +G N +F+ C+ L ++F E NC Y I S + FNCYT +P S N + + +I+ P+PK+ ++ Q + G +++VHE G+ P +H+EP ++ +I Y N W+ +TP C++++ + DL N Y++T CL A+ + ++ +C C+ + PR ++P+E PYC + + D + + +C+S+ L + + + K C+ C F+ IS KW T W L WL + S + F K NR++ E +A L + N KD+ + N KD+ +A +VL R S ++ K E+L ++ Y LVSRIGG C+L +G+T AF +E++EF + +++ KR+ + V+ + L Sbjct: 55 FQPKNFFILFCSTISIRGINKIIKGPRPLRLLWLCFVLIMSAILITSSCL-LVRDFMLYDVNINTKLEIDSMTPFPALTVCHHHPFSHRGYRMWKSGKAMSPSYFNRKMRNLTLDQLLLNDVESAETISYYDGISIYYQNLPYEQAIQMGHNS-SIFLTCMYLLENQIYFAE---NCTKLEFYRIKLLSHHEHFNCYTFEPTQPHVSSNLDMLGIIVSLGPEPKHFDMEQSFIIDTFRQAQ--GLKVIVHESGTLPDIDEAGLHVEPGKMNEIIYRPNQWQLTNTPAKPCINDTSRIAYV-DLANTYNYTKHLCLKYAEQEDIMNQCHCMFIYNPRPMMPNESMPYCGSI--LKDFNLSNIYSYVKCLSDVLNQKSKRQQWEKEKCFHRCNYMTFDSTISITKWRATEWHLYWLRQQITSLGEMKQFLKANPNRNVTESQAFKTWLIYGNKKDLRK-TGLKANEFLLKDDNFAYIVLRRESKDSVKKYERLVITQYVLVSRIGGLCSLTVGITLAFIVELVEFCYLFSAKETEKRKRKYSNSVENVKL 591
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000062815.1 (SMESG000062815.1) HSP 1 Score: 236.113 bits (601), Expect = 5.218e-69 Identity = 161/524 (30.73%), Postives = 272/524 (51.91%), Query Frame = 2 Query: 125 KEFFNNCSIRGVAKVYKSNSXXXXXXXXXXXXXXXXXXXYSIVKILREYLEYNTTIQTKLQLEDASPFPAITICPYQPFSERAVEYF-QNKGMSPKEFSWKLRKSAKRYL-----------EKDQPHIAESILFYDDLRIYYQNLKYEESTYIGLNDKELFVFCITKLGIGMFFGEVRENCGYNITRHSSPDFFNCYTINVKPEYSLNTEYIHLILRFPKPKNLEIFQXXXXXXXXXXXXXGAQLLVHERGSSPVSTREKIHIEPNRLLQINYGNNYWKEYSTPNDICLSESKMTEKITDLDNEYSFTFQGCLDSAKAKRVLEKCQCVMAFLPRLVIPSEQYPYCANFRNMSDEDFKEFWKRGRCISETLTKDKELENMY---KNCYKSCIRQKFNLQISNIKWTPTLWQLEWLFKLQQSW----NVL---IDFPKN------RSIVEKAKADALRFLNAKDINELISENENSIFQKDEKYACVVLERLSNETFYKEEKLGLSLYGLVSRIGGSCTLYLGLTCA 1612 ++FF N SIRG +++ KS + ++ +WI+F+ +T L+ SI K++ +Y +Y+ IQT +Q+++A+PFPA+T C +QPFSERA + + ++K MSP +F+ R A + + D H D L +YYQNL S+ +G N + C+ G M F ++ + S P +FNC+T+ P+Y+ + LI+ + I + L + G ++++HE S P E + IEP RL ++NY + T C++E + DLDN + + C + +R++ +C+C+ + PR + PS++ PYC + E + + R CI++ + ++++ K C SC ++ S KW PT WQL WL ++ +W N++ I+ P N R +++ + F K+++E I E+E +F +E+Y VV++R +N TF KEE+L LS LVSR+GG C+LY+GLT A Sbjct: 18 RKFFANTSIRGFSRIVKSETTFLRTLWILFVVSTITFLIVSIFKVVIDYRQYSVNIQTYIQIDNATPFPALTFCNHQPFSERAYQLWEESKVMSPTQFNELFRSEALKQFKDMVRTKMTPKDSDFNHPLFLTTINDRLSVYYQNLPTTVSSELGHN-ISIIKNCVWSYGQHMAFDNHCQDDMLIVKNISHPSYFNCFTVEPHPKYASIFSRLGLIIWLGPDEQTNIKHRQGFLFDIFEQAYGLRVIIHEPNSYPNIESEGVQIEPGRLNELNYQPELNIKVDTERKPCINEPDRIYR--DLDNVFKYDIDLCFNMELQQRIITECKCIYGYYPRYLHPSKELPYCG---YLEPEKYHDLLFRKNCITKIFNEAPDIKSNLKADKKCIHSCSSIEYTTTTSVTKWRPTDWQLYWLKEVLDAWAQYYNLMARNINIPSNNMTTTDRIMLQNLTSRIETFFTRKNLSEFIPESEKLLF--NERYTFVVVKRKANNTFIKEERLVLSFNALVSRVGGLCSLYIGLTFA 533 The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 1
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003924 ID=SMED30003924|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1828bpback to top protein sequence of SMED30003924-orf-1 >SMED30003924-orf-1 ID=SMED30003924-orf-1|Name=SMED30003924-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=564bp MKIRNSGKFKRKEFFNNCSIRGVAKVYKSNSKIIKIMWIIFLFIMMTLLLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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