Peptidylprolyl isomerase

Overview
NamePeptidylprolyl isomerase
Smed IDSMED30003871
Length (bp)588
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Peptidylprolyl isomerase (SMED30003871) t-SNE clustered cells

Violin plots show distribution of expression levels for Peptidylprolyl isomerase (SMED30003871) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Peptidylprolyl isomerase (SMED30003871) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Peptidylprolyl isomerase (SMED30003871) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30003871

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30003871h1SMcG0000358 Contig46934uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30003871h1SMcG0000358 Contig46934newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
cephalic gangliaSMED30003871h1SMcG0000358 dd_Smed_v4_2765_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30003871h1SMcG0000358 dd_Smed_v4_2765_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30003871h1SMcG0000358 dd_Smed_v4_2765_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Peptidylprolyl isomerase vs. Ensembl Human
Match: FKBP2 (FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HGNC:3718])

HSP 1 Score: 103.605 bits (257), Expect = 6.054e-28
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 3
Query:  102 YFLGMKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +F  +  + + L AV   T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++++
Sbjct:    5 WFRVLTVLSICLSAVATATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTE 141          
BLAST of Peptidylprolyl isomerase vs. Ensembl Human
Match: FKBP2 (FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HGNC:3718])

HSP 1 Score: 103.605 bits (257), Expect = 6.054e-28
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 3
Query:  102 YFLGMKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +F  +  + + L AV   T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++++
Sbjct:    5 WFRVLTVLSICLSAVATATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTE 141          
BLAST of Peptidylprolyl isomerase vs. Ensembl Human
Match: FKBP2 (FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HGNC:3718])

HSP 1 Score: 103.605 bits (257), Expect = 6.054e-28
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 3
Query:  102 YFLGMKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +F  +  + + L AV   T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++++
Sbjct:    5 WFRVLTVLSICLSAVATATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTE 141          
BLAST of Peptidylprolyl isomerase vs. Ensembl Human
Match: AP001453.5 (Uncharacterized protein LOC114841035 [Source:NCBI gene;Acc:114841035])

HSP 1 Score: 103.605 bits (257), Expect = 6.054e-28
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 3
Query:  102 YFLGMKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +F  +  + + L AV   T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++++
Sbjct:    5 WFRVLTVLSICLSAVATATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTE 141          
BLAST of Peptidylprolyl isomerase vs. Ensembl Human
Match: FKBP2 (FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HGNC:3718])

HSP 1 Score: 103.99 bits (258), Expect = 1.012e-27
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 3
Query:  102 YFLGMKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +F  +  + + L AV   T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++++
Sbjct:   34 WFRVLTVLSICLSAVATATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTE 170          
BLAST of Peptidylprolyl isomerase vs. Ensembl Celegans
Match: fkb-1 (Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL;Acc:Q20107])

HSP 1 Score: 103.605 bits (257), Expect = 2.420e-28
Identity = 53/133 (39.85%), Postives = 82/133 (61.65%), Query Frame = 3
Query:  114 MKQIFLV-LFAVLALT-NVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            MK   +V L  +LA+    +  +I +LQ  +  ++ +C  K+   D +  HY GT   +G +FDSS  R + + FT+ +G VI+G ++G+  MCVGERR++TIP  + YGERG  P IP +S L F VE+++I
Sbjct:    1 MKTAVIVGLLCLLAIAYAADEQKIDKLQIGVKKRAENCVQKSRKGDQLHMHYTGTLL-DGTEFDSSRTRNEEFTFTLGQGNVIKGWDQGLLNMCVGERRILTIPPHLGYGERGAPPKIPGNSVLKFDVELMKI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Celegans
Match: fkb-1 (Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL;Acc:Q20107])

HSP 1 Score: 103.605 bits (257), Expect = 2.420e-28
Identity = 53/133 (39.85%), Postives = 82/133 (61.65%), Query Frame = 3
Query:  114 MKQIFLV-LFAVLALT-NVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            MK   +V L  +LA+    +  +I +LQ  +  ++ +C  K+   D +  HY GT   +G +FDSS  R + + FT+ +G VI+G ++G+  MCVGERR++TIP  + YGERG  P IP +S L F VE+++I
Sbjct:    1 MKTAVIVGLLCLLAIAYAADEQKIDKLQIGVKKRAENCVQKSRKGDQLHMHYTGTLL-DGTEFDSSRTRNEEFTFTLGQGNVIKGWDQGLLNMCVGERRILTIPPHLGYGERGAPPKIPGNSVLKFDVELMKI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Celegans
Match: fkb-1 (Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL;Acc:Q20107])

HSP 1 Score: 103.605 bits (257), Expect = 2.420e-28
Identity = 53/133 (39.85%), Postives = 82/133 (61.65%), Query Frame = 3
Query:  114 MKQIFLV-LFAVLALT-NVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            MK   +V L  +LA+    +  +I +LQ  +  ++ +C  K+   D +  HY GT   +G +FDSS  R + + FT+ +G VI+G ++G+  MCVGERR++TIP  + YGERG  P IP +S L F VE+++I
Sbjct:    1 MKTAVIVGLLCLLAIAYAADEQKIDKLQIGVKKRAENCVQKSRKGDQLHMHYTGTLL-DGTEFDSSRTRNEEFTFTLGQGNVIKGWDQGLLNMCVGERRILTIPPHLGYGERGAPPKIPGNSVLKFDVELMKI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Celegans
Match: fkb-2 (Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL;Acc:Q9U2Q8])

HSP 1 Score: 91.6633 bits (226), Expect = 4.118e-24
Identity = 45/97 (46.39%), Postives = 63/97 (64.95%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            D   K  +   V+ HYV T  ENG K DSS DRG P++F I +GEVI+G ++G+  M VGE+  +TI + + YG RG  P IP ++ LVF+VE+L +
Sbjct:   12 DNVTKPKNGQTVTCHYVLTL-ENGKKIDSSRDRGTPFKFKIGKGEVIKGWDQGVAQMSVGEKSKLTISADLGYGPRGVPPQIPANATLVFEVELLGV 107          
BLAST of Peptidylprolyl isomerase vs. Ensembl Celegans
Match: fkb-1 (Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL;Acc:Q20107])

HSP 1 Score: 88.1965 bits (217), Expect = 5.559e-23
Identity = 41/83 (49.40%), Postives = 58/83 (69.88%), Query Frame = 3
Query:  258 HYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            HY GT   +G +FDSS  R + + FT+ +G VI+G ++G+  MCVGERR++TIP  + YGERG  P IP +S L F VE+++I
Sbjct:    2 HYTGTLL-DGTEFDSSRTRNEEFTFTLGQGNVIKGWDQGLLNMCVGERRILTIPPHLGYGERGAPPKIPGNSVLKFDVELMKI 83          
BLAST of Peptidylprolyl isomerase vs. Ensembl Fly
Match: Fkbp14 (gene:FBgn0010470 transcript:FBtr0342897)

HSP 1 Score: 106.686 bits (265), Expect = 1.359e-28
Identity = 44/96 (45.83%), Postives = 66/96 (68.75%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            C  K+ + D ++ HY GT   +G KFDSS+DR QP+ F +  G+VI+G ++G+  MCVGE+R +TIP  + YG++G   VIPP + L+F VE++ I
Sbjct:   37 CEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELINI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Fly
Match: Fkbp14 (gene:FBgn0010470 transcript:FBtr0071703)

HSP 1 Score: 106.686 bits (265), Expect = 1.359e-28
Identity = 44/96 (45.83%), Postives = 66/96 (68.75%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            C  K+ + D ++ HY GT   +G KFDSS+DR QP+ F +  G+VI+G ++G+  MCVGE+R +TIP  + YG++G   VIPP + L+F VE++ I
Sbjct:   37 CEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELINI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Fly
Match: Fkbp14 (gene:FBgn0010470 transcript:FBtr0342896)

HSP 1 Score: 106.686 bits (265), Expect = 1.359e-28
Identity = 44/96 (45.83%), Postives = 66/96 (68.75%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            C  K+ + D ++ HY GT   +G KFDSS+DR QP+ F +  G+VI+G ++G+  MCVGE+R +TIP  + YG++G   VIPP + L+F VE++ I
Sbjct:   37 CEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELINI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Fly
Match: Fkbp14 (gene:FBgn0010470 transcript:FBtr0300397)

HSP 1 Score: 106.686 bits (265), Expect = 1.359e-28
Identity = 44/96 (45.83%), Postives = 66/96 (68.75%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            C  K+ + D ++ HY GT   +G KFDSS+DR QP+ F +  G+VI+G ++G+  MCVGE+R +TIP  + YG++G   VIPP + L+F VE++ I
Sbjct:   37 CEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELINI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Fly
Match: Fkbp14 (gene:FBgn0010470 transcript:FBtr0306013)

HSP 1 Score: 106.686 bits (265), Expect = 1.478e-28
Identity = 44/96 (45.83%), Postives = 66/96 (68.75%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            C  K+ + D ++ HY GT   +G KFDSS+DR QP+ F +  G+VI+G ++G+  MCVGE+R +TIP  + YG++G   VIPP + L+F VE++ I
Sbjct:   37 CEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELINI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Zebrafish
Match: fkbp2 (FKBP prolyl isomerase 2 [Source:ZFIN;Acc:ZDB-GENE-040912-126])

HSP 1 Score: 107.842 bits (268), Expect = 9.270e-30
Identity = 51/133 (38.35%), Postives = 81/133 (60.90%), Query Frame = 3
Query:  123 IFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +  V    + +  V+  +  +LQ  I  +  +C  K+   D ++ HY G   E+G +FDSS  R QP+ FT+  G+VI+G ++G+ GMC GE+R + IPS + YG+RG  P IP  + L+F+VE+L I ++SD
Sbjct:    6 LLAVTLVSIPMALVQGAEKKKLQIGIKKRVDNCPIKSRKGDVLNMHYTGKL-EDGTEFDSSIPRNQPFTFTLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRGAPPKIPGGATLIFEVELLNIERRSD 137          
BLAST of Peptidylprolyl isomerase vs. Ensembl Zebrafish
Match: fkbp9 (FKBP prolyl isomerase 9 [Source:ZFIN;Acc:ZDB-GENE-040801-23])

HSP 1 Score: 107.842 bits (268), Expect = 4.472e-27
Identity = 59/139 (42.45%), Postives = 82/139 (58.99%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTNVESNQISELQSIIVNKS--PD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            ++ I ++L A L      +     L  I++ K+  P+ C     S DYV YHY+G F  +G KFDSSYDRG  Y   + + ++I GM++ + GMCV ER +I IP  +AYG+ GY  +IPPDS L F V ML+I  K D
Sbjct:    2 IRLIQMILLAFLVTFVACNAPPVPLDDIVIEKTFTPERCERAVKSGDYVRYHYIGMF-PDGKKFDSSYDRGNTYNVFVGQKQLIAGMDKALVGMCVNERWMIKIPPQLAYGKDGYGDIIPPDSILHFDVLMLDIWNKED 139          

HSP 2 Score: 88.9669 bits (219), Expect = 2.173e-20
Identity = 55/135 (40.74%), Postives = 75/135 (55.56%), Query Frame = 3
Query:  120 QIFLVLFAVLALTNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            Q  LV   VL   +   ++I+    + V   PD C  K+   D++ YHY G+  + G  FDSSY R   Y   I +G VI GM++G+ G+CVGERR ITIP  +AYGE G    IP  + LVF V +++    SD
Sbjct:  234 QASLVFDVVLLDLHNPKDEIA----VKVEYLPDPCPRKSQVGDFMRYHYNGSLLD-GTFFDSSYSRNHTYDTYIGKGYVIAGMDQGLLGVCVGERRRITIPPHLAYGEEGTGTKIPGSAVLVFDVHIIDFHNPSD 363          

HSP 3 Score: 86.2705 bits (212), Expect = 1.894e-19
Identity = 45/117 (38.46%), Postives = 66/117 (56.41%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N+  ++Q    +    C  K    DY+ YHY GT  + G  FDSS+ R + Y   +  G +I GM++G+ GMCVGE+R+IT+P  + YGE G    IP  + LVF V +L++    D
Sbjct:  136 NKEDKVQIKTYHMPESCERKVQVSDYIRYHYNGTLLD-GTLFDSSHTRMRTYDTYVGIGWLIAGMDQGLLGMCVGEKRIITLPPFLGYGENGDGSDIPAQASLVFDVVLLDLHNPKD 251          

HSP 4 Score: 83.1889 bits (204), Expect = 2.172e-18
Identity = 41/115 (35.65%), Postives = 67/115 (58.26%), Query Frame = 3
Query:  162 VESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            ++ +  S+   I   K  +C+  A   D+V YHY  T  +  D   S++  G+ Y   +  G+V+ GM +G+ GMC+GE+R + IP  +AYGERG    +P  + LVF+VEM+++
Sbjct:  356 IDFHNPSDTVEITSVKPENCTYNAKRGDFVKYHYNATLMDGTD-IGSTHMYGKTYNVVLGSGQVVIGMEQGLTGMCIGEKRKLVIPPHLAYGERGVDGEVPGSAVLVFEVEMVDV 469          
BLAST of Peptidylprolyl isomerase vs. Ensembl Zebrafish
Match: fkbp1b (FKBP prolyl isomerase 1B [Source:ZFIN;Acc:ZDB-GENE-040426-1785])

HSP 1 Score: 88.1965 bits (217), Expect = 1.553e-22
Identity = 41/83 (49.40%), Postives = 57/83 (68.67%), Query Frame = 3
Query:  258 HYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            HY+G   +NG KFDSS DR +P++F I R EVI+G  EG+  M +G+R  IT    MAYG  G+  VIPP++ L+F VE+L++
Sbjct:   26 HYIGML-QNGKKFDSSRDRNKPFKFKIGRQEVIKGWEEGVAQMSLGQRAKITCTPDMAYGATGHPGVIPPNATLIFDVELLKL 107          
BLAST of Peptidylprolyl isomerase vs. Ensembl Zebrafish
Match: fkbp10b (FKBP prolyl isomerase 10b [Source:ZFIN;Acc:ZDB-GENE-030131-3101])

HSP 1 Score: 94.7449 bits (234), Expect = 2.402e-22
Identity = 43/101 (42.57%), Postives = 66/101 (65.35%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            C  +  S D+V YHY GTF  +G +FDSSY+RG  +   + +   I G+++GI GMC+ ERR IT+P  +A+G +G    +PPD+ LVF + +L+I  ++D
Sbjct:   87 CVREVKSGDFVRYHYNGTF-TDGKRFDSSYERGTAFFGQVGQRWQIAGVDKGILGMCINERRKITVPPHLAHGSKGAGDTVPPDTTLVFDLVLLDIFNRAD 186          

HSP 2 Score: 84.7297 bits (208), Expect = 6.357e-19
Identity = 40/117 (34.19%), Postives = 67/117 (57.26%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N+  ++Q+ +++   DC       D+V +H+ GT  + G  FDSSY R Q     +  G +I+G++EG+ GMCVGE R   IP  +A+GE+GY   IPP + + + + + ++    D
Sbjct:  183 NRADQVQTKVISTPKDCRRSVMRTDFVRFHFNGTLLD-GTVFDSSYKRSQTQDSVVGEGLLIKGLDEGLLGMCVGEIRHFIIPPFLAFGEQGYGTGIPPHASVEYHILLEDLHNPKD 298          

HSP 3 Score: 77.411 bits (189), Expect = 1.974e-16
Identity = 37/95 (38.95%), Postives = 60/95 (63.16%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLE 503
            C+ K+ + D++ YHY  +F  NG  FDSSY + Q Y   I  G +I G+++G++G+C GE R I +P  +AYG++G    IP  + LVF + +++
Sbjct:  311 CARKSVAGDFIRYHYNASFL-NGIMFDSSYQQNQTYNTYIGMGYMIAGIDKGLQGVCAGEWRRIILPPHLAYGQQGAGKDIPGSAVLVFDIHVID 404          

HSP 4 Score: 69.3218 bits (168), Expect = 1.450e-13
Identity = 32/109 (29.36%), Postives = 65/109 (59.63%), Query Frame = 3
Query:  186 LQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILK 512
            +Q  ++++S  C+  +   D++ YHY  +  + G    SS+D   P    +   ++I+G++E ++ MCVGERR + +P  + +GE+G + ++P  + L F++E+L + K
Sbjct:  412 VQVDVLHRSEACNESSEVNDFIQYHYNCSLLD-GTLLFSSHDYETPQNVLLGGDKIIDGLDEALRNMCVGERRTVIVPPHLGHGEKG-AGIVPGSAVLRFELELLSLQK 518          
BLAST of Peptidylprolyl isomerase vs. Ensembl Zebrafish
Match: fkbp7 (FKBP prolyl isomerase 7 [Source:ZFIN;Acc:ZDB-GENE-030616-182])

HSP 1 Score: 90.5077 bits (223), Expect = 3.725e-22
Identity = 49/141 (34.75%), Postives = 85/141 (60.28%), Query Frame = 3
Query:  105 FLGMKQIFLVLFAVLAL----TNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKF--DSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            FL     F ++ ++ AL    T + +N+ +E   I V   P+ CS KA   D ++ HY G   ++G +F    + ++G P+ F +  G +I+G++  ++ MC GE+R +TIP ++AYGE+G  PV PP++ ++F+VE+L I
Sbjct:    5 FLRFLFYFCLILSLQALYPFITIIRANETNEDVKIEVTFLPENCSQKAKRGDMLNAHYDGFLAKDGSQFYCSRTTEKGHPHWFVLGVGNIIKGLDVALQDMCPGEKRKVTIPPSLAYGEKGNGPV-PPNATVIFEVELLHI 144          
BLAST of Peptidylprolyl isomerase vs. Ensembl Xenopus
Match: fkbp2 (FKBP prolyl isomerase 2 [Source:NCBI gene;Acc:100135178])

HSP 1 Score: 105.531 bits (262), Expect = 9.607e-29
Identity = 52/132 (39.39%), Postives = 84/132 (63.64%), Query Frame = 3
Query:  126 FLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            FLVLF + +++  E  +  +LQ  +  +  +C  K+   D +  HY G   E+G +FDSS  R Q + FT+  G+VI+G ++G+ GMC GE+R + IPS + YG+RG  P IP  + L+F+VE+++I ++SD
Sbjct:   12 FLVLFLLPSVSASEGRK--KLQIGVKKRVENCLVKSRKGDTLHMHYTGKL-EDGTEFDSSIPRNQAFTFTLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRGAPPKIPGGATLIFEVELVKIERRSD 140          
BLAST of Peptidylprolyl isomerase vs. Ensembl Xenopus
Match: fkbp9 (FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:100125793])

HSP 1 Score: 105.916 bits (263), Expect = 3.764e-26
Identity = 58/143 (40.56%), Postives = 82/143 (57.34%), Query Frame = 3
Query:  108 LGMKQIFLVLFAVLALTNVESNQISEL--QSIIVNKS--PD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            LG +   L L A   ++ V  N    +    + + K   PD C       D+V YHY GTF  +G KFDSSYDRG  Y   + +G++I GM++ + GMCV ERR + IP ++AYG +G + VIPPD+ L F V +L+I   +D
Sbjct:   56 LGSRWPVLALQAAFLVSFVTCNDAPPVPGDQLHIEKRWVPDTCQRHVTEGDFVRYHYHGTF-PDGTKFDSSYDRGSTYNVFVGKGQIIAGMDKALLGMCVNERRFVKIPPSLAYGSKGLADVIPPDAVLHFDVLLLDIWNPTD 197          

HSP 2 Score: 82.0333 bits (201), Expect = 7.660e-18
Identity = 44/117 (37.61%), Postives = 64/117 (54.70%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N    +Q     K  +CS      DY+ YHY G+  + G  FDSS++R + Y   +  G +I GM+ G+ GMCVGE+R+I +P  + YGE G    IP  + LVF V +L++    D
Sbjct:  194 NPTDTVQVETYYKPENCSRLVEVSDYIRYHYNGSLLD-GTLFDSSHNRMRTYDTYVGIGWLIPGMDTGLLGMCVGEKRIIKVPPFLGYGEDGDGKDIPSQASLVFDVVLLDLHNPKD 309          

HSP 3 Score: 80.8777 bits (198), Expect = 2.115e-17
Identity = 41/102 (40.20%), Postives = 58/102 (56.86%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            DC  +    D++ YHY G+  + G  FDSSY R   Y   I +G VI GM+EG+ G+C GE+R +TIP  + YGE G    IP  + LVF + +++     D
Sbjct:  321 DCERRTQVGDFIRYHYNGSLLD-GTLFDSSYSRKHTYDTYIGKGYVIAGMDEGLLGLCTGEKRRVTIPPHLGYGEEGRGK-IPGSAVLVFDIHVIDFHNPED 420          

HSP 4 Score: 78.5666 bits (192), Expect = 1.088e-16
Identity = 37/101 (36.63%), Postives = 60/101 (59.41%), Query Frame = 3
Query:  207 KSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEIL 509
            K  +CS  +   DY+ YHY  T  + G   DS++  G+ Y   +  G+V+ GM+ G++ MC+GE+R I IP  + YGE G    +P  + LVF +E+L+++
Sbjct:  429 KPSNCSVLSKKGDYLKYHYNATLMD-GTVLDSTHQYGKTYNIVLGSGQVVMGMDIGLQDMCIGEKRNIVIPPHLGYGEAGVEGEVPGSAVLVFDIELLDLI 528          
BLAST of Peptidylprolyl isomerase vs. Ensembl Xenopus
Match: fkbp9 (FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:100125793])

HSP 1 Score: 105.916 bits (263), Expect = 4.046e-26
Identity = 58/143 (40.56%), Postives = 82/143 (57.34%), Query Frame = 3
Query:  108 LGMKQIFLVLFAVLALTNVESNQISEL--QSIIVNKS--PD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            LG +   L L A   ++ V  N    +    + + K   PD C       D+V YHY GTF  +G KFDSSYDRG  Y   + +G++I GM++ + GMCV ERR + IP ++AYG +G + VIPPD+ L F V +L+I   +D
Sbjct:   56 LGSRWPVLALQAAFLVSFVTCNDAPPVPGDQLHIEKRWVPDTCQRHVTEGDFVRYHYHGTF-PDGTKFDSSYDRGSTYNVFVGKGQIIAGMDKALLGMCVNERRFVKIPPSLAYGSKGLADVIPPDAVLHFDVLLLDIWNPTD 197          

HSP 2 Score: 82.0333 bits (201), Expect = 8.017e-18
Identity = 44/117 (37.61%), Postives = 64/117 (54.70%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N    +Q     K  +CS      DY+ YHY G+  + G  FDSS++R + Y   +  G +I GM+ G+ GMCVGE+R+I +P  + YGE G    IP  + LVF V +L++    D
Sbjct:  194 NPTDTVQVETYYKPENCSRLVEVSDYIRYHYNGSLLD-GTLFDSSHNRMRTYDTYVGIGWLIPGMDTGLLGMCVGEKRIIKVPPFLGYGEDGDGKDIPSQASLVFDVVLLDLHNPKD 309          

HSP 3 Score: 80.8777 bits (198), Expect = 2.130e-17
Identity = 41/102 (40.20%), Postives = 58/102 (56.86%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            DC  +    D++ YHY G+  + G  FDSSY R   Y   I +G VI GM+EG+ G+C GE+R +TIP  + YGE G    IP  + LVF + +++     D
Sbjct:  321 DCERRTQVGDFIRYHYNGSLLD-GTLFDSSYSRKHTYDTYIGKGYVIAGMDEGLLGLCTGEKRRVTIPPHLGYGEEGRGK-IPGSAVLVFDIHVIDFHNPED 420          

HSP 4 Score: 78.5666 bits (192), Expect = 1.127e-16
Identity = 37/101 (36.63%), Postives = 60/101 (59.41%), Query Frame = 3
Query:  207 KSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEIL 509
            K  +CS  +   DY+ YHY  T  + G   DS++  G+ Y   +  G+V+ GM+ G++ MC+GE+R I IP  + YGE G    +P  + LVF +E+L+++
Sbjct:  429 KPSNCSVLSKKGDYLKYHYNATLMD-GTVLDSTHQYGKTYNIVLGSGQVVMGMDIGLQDMCIGEKRNIVIPPHLGYGEAGVEGEVPGSAVLVFDIELLDLI 528          
BLAST of Peptidylprolyl isomerase vs. Ensembl Xenopus
Match: fkbp9 (FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:100125793])

HSP 1 Score: 104.76 bits (260), Expect = 8.879e-26
Identity = 57/139 (41.01%), Postives = 80/139 (57.55%), Query Frame = 3
Query:  120 QIFLVLFAVLALTNVESNQISEL--QSIIVNKS--PD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            Q   VL A   ++ V  N    +    + + K   PD C       D+V YHY GTF  +G KFDSSYDRG  Y   + +G++I GM++ + GMCV ERR + IP ++AYG +G + VIPPD+ L F V +L+I   +D
Sbjct:    2 QFNTVLLAAFLVSFVTCNDAPPVPGDQLHIEKRWVPDTCQRHVTEGDFVRYHYHGTF-PDGTKFDSSYDRGSTYNVFVGKGQIIAGMDKALLGMCVNERRFVKIPPSLAYGSKGLADVIPPDAVLHFDVLLLDIWNPTD 139          

HSP 2 Score: 81.6481 bits (200), Expect = 1.120e-17
Identity = 44/117 (37.61%), Postives = 64/117 (54.70%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N    +Q     K  +CS      DY+ YHY G+  + G  FDSS++R + Y   +  G +I GM+ G+ GMCVGE+R+I +P  + YGE G    IP  + LVF V +L++    D
Sbjct:  136 NPTDTVQVETYYKPENCSRLVEVSDYIRYHYNGSLLD-GTLFDSSHNRMRTYDTYVGIGWLIPGMDTGLLGMCVGEKRIIKVPPFLGYGEDGDGNDIPSQASLVFDVVLLDLHNPKD 251          

HSP 3 Score: 80.8777 bits (198), Expect = 2.129e-17
Identity = 41/102 (40.20%), Postives = 58/102 (56.86%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            DC  +    D++ YHY G+  + G  FDSSY R   Y   I +G VI GM+EG+ G+C GE+R +TIP  + YGE G    IP  + LVF + +++     D
Sbjct:  263 DCERRTQVGDFIRYHYNGSLLD-GTLFDSSYSRKHTYDTYIGKGYVIAGMDEGLLGLCTGEKRRVTIPPHLGYGEEGRGK-IPGSAVLVFDIHVIDFHNPED 362          

HSP 4 Score: 78.9518 bits (193), Expect = 1.015e-16
Identity = 37/101 (36.63%), Postives = 60/101 (59.41%), Query Frame = 3
Query:  207 KSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEIL 509
            K  +CS  +   DY+ YHY  T  + G   DS++  G+ Y   +  G+V+ GM+ G++ MC+GE+R I IP  + YGE G    +P  + LVF +E+L+++
Sbjct:  371 KPSNCSVLSKKGDYLKYHYNATLMD-GTVLDSTHQYGKTYNIVLGSGQVVMGMDIGLQDMCIGEKRNIVIPPHLGYGEAGVEGEVPGSAVLVFDIELLDLI 470          
BLAST of Peptidylprolyl isomerase vs. Ensembl Xenopus
Match: fkbp9 (FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:100125793])

HSP 1 Score: 104.76 bits (260), Expect = 9.391e-26
Identity = 57/140 (40.71%), Postives = 81/140 (57.86%), Query Frame = 3
Query:  108 LGMKQIFLVLFAVLA-LTNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            L ++  FLV F        V  +Q+   +  +    PD C       D+V YHY GTF  +G KFDSSYDRG  Y   + +G++I GM++ + GMCV ERR + IP ++AYG +G + VIPPD+ L F V +L+I   +D
Sbjct:   12 LALQAAFLVSFVTCNDAPPVPGDQLHIEKRWV----PDTCQRHVTEGDFVRYHYHGTF-PDGTKFDSSYDRGSTYNVFVGKGQIIAGMDKALLGMCVNERRFVKIPPSLAYGSKGLADVIPPDAVLHFDVLLLDIWNPTD 146          

HSP 2 Score: 82.0333 bits (201), Expect = 8.600e-18
Identity = 44/117 (37.61%), Postives = 64/117 (54.70%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N    +Q     K  +CS      DY+ YHY G+  + G  FDSS++R + Y   +  G +I GM+ G+ GMCVGE+R+I +P  + YGE G    IP  + LVF V +L++    D
Sbjct:  143 NPTDTVQVETYYKPENCSRLVEVSDYIRYHYNGSLLD-GTLFDSSHNRMRTYDTYVGIGWLIPGMDTGLLGMCVGEKRIIKVPPFLGYGEDGDGKDIPSQASLVFDVVLLDLHNPKD 258          

HSP 3 Score: 80.4925 bits (197), Expect = 2.331e-17
Identity = 41/102 (40.20%), Postives = 58/102 (56.86%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            DC  +    D++ YHY G+  + G  FDSSY R   Y   I +G VI GM+EG+ G+C GE+R +TIP  + YGE G    IP  + LVF + +++     D
Sbjct:  270 DCERRTQVGDFIRYHYNGSLLD-GTLFDSSYSRKHTYDTYIGKGYVIAGMDEGLLGLCTGEKRRVTIPPHLGYGEEGRGK-IPGSAVLVFDIHVIDFHNPED 369          

HSP 4 Score: 78.5666 bits (192), Expect = 1.165e-16
Identity = 37/101 (36.63%), Postives = 60/101 (59.41%), Query Frame = 3
Query:  207 KSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEIL 509
            K  +CS  +   DY+ YHY  T  + G   DS++  G+ Y   +  G+V+ GM+ G++ MC+GE+R I IP  + YGE G    +P  + LVF +E+L+++
Sbjct:  378 KPSNCSVLSKKGDYLKYHYNATLMD-GTVLDSTHQYGKTYNIVLGSGQVVMGMDIGLQDMCIGEKRNIVIPPHLGYGEAGVEGEVPGSAVLVFDIELLDLI 477          
BLAST of Peptidylprolyl isomerase vs. Ensembl Mouse
Match: Fkbp2 (FK506 binding protein 2 [Source:MGI Symbol;Acc:MGI:95542])

HSP 1 Score: 103.99 bits (258), Expect = 2.667e-28
Identity = 52/131 (39.69%), Postives = 81/131 (61.83%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            + L A+ A T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++S+
Sbjct:   12 ICLSALAAATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRSE 139          
BLAST of Peptidylprolyl isomerase vs. Ensembl Mouse
Match: Fkbp2 (FK506 binding protein 2 [Source:MGI Symbol;Acc:MGI:95542])

HSP 1 Score: 103.99 bits (258), Expect = 2.667e-28
Identity = 52/131 (39.69%), Postives = 81/131 (61.83%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            + L A+ A T  E  +  +LQ  +  +   C  K+   D +  HY G   E+G +FDSS  + QP+ F++  G+VI+G ++G+ GMC GE+R + IPS + YGERG  P IP  + LVF+VE+L+I ++S+
Sbjct:   12 ICLSALAAATGAEGKR--KLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL-EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRSE 139          
BLAST of Peptidylprolyl isomerase vs. Ensembl Mouse
Match: Fkbp10 (FK506 binding protein 10 [Source:MGI Symbol;Acc:MGI:104769])

HSP 1 Score: 103.99 bits (258), Expect = 1.476e-25
Identity = 52/117 (44.44%), Postives = 72/117 (61.54%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N+   +QS I+ + P C     + D+V YHY GT  + G  FD+SY RG  Y   I  G +I+GM++G+ GMC GE+R I IP  +AYGE+GY  VIPP + LVF V +L++    D
Sbjct:  150 NKADTVQSTILLRPPYCPRMVQNSDFVRYHYNGTLLD-GTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLVFYVLLLDVHNPKD 265          

HSP 2 Score: 93.5893 bits (231), Expect = 4.996e-22
Identity = 45/101 (44.55%), Postives = 62/101 (61.39%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            C  +    D+V YHY GTF E+G KFDSSYDR       +  G +I GM+ G+ GMCV ERR + +P  + YG  G + +IPPD+ L F V +L++  K+D
Sbjct:   54 CPREVQMGDFVRYHYNGTF-EDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPDATLYFDVVLLDVWNKAD 153          

HSP 3 Score: 87.8113 bits (216), Expect = 5.134e-20
Identity = 46/130 (35.38%), Postives = 75/130 (57.69%), Query Frame = 3
Query:  132 VLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            ++F VL L         +L+++ + +   C  +A + D++ YHY G+  + G  FDSSY R   Y   + +G +I GM++G++G C+GERR IT+P  +AYGE G    IP  + L+F V +++    SD
Sbjct:  251 LVFYVLLLDVHNPKDTVQLETLELPQG--CVRRAVAGDFMRYHYNGSLMD-GTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFHNPSD 377          

HSP 4 Score: 69.707 bits (169), Expect = 9.216e-14
Identity = 35/95 (36.84%), Postives = 59/95 (62.11%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEML 500
            +C+  +   D++ YHY  +  + G +  SS+D   P   T+   +VIEG++ G++GMCVGERR + +P  +A+GE G   V P  + L+F+VE++
Sbjct:  390 NCNETSKIGDFIRYHYNCSLLD-GTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARGV-PGSAVLLFEVELV 482          
BLAST of Peptidylprolyl isomerase vs. Ensembl Mouse
Match: Fkbp9 (FK506 binding protein 9 [Source:MGI Symbol;Acc:MGI:1350921])

HSP 1 Score: 103.605 bits (257), Expect = 1.575e-25
Identity = 56/115 (48.70%), Postives = 74/115 (64.35%), Query Frame = 3
Query:  180 SELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            SELQ I  +  PD C     S D+V YHYVGTF + G KFDSSYDR   +   + +G++I GM++ + GMCV ERR++TIP  +AYG  G S VIPP+S L F V +++I    D
Sbjct:   34 SELQ-IQQSFVPDECPRTVHSGDFVRYHYVGTFLD-GQKFDSSYDRDSTFNVFVGKGQLIAGMDQALVGMCVNERRLVTIPPNLAYGSEGVSGVIPPNSVLHFDVLLVDIWNSED 146          

HSP 2 Score: 92.0485 bits (227), Expect = 2.268e-21
Identity = 46/105 (43.81%), Postives = 64/105 (60.95%), Query Frame = 3
Query:  207 KSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            K P C       D+V YHY GTF + G  FDSS++R + Y   +  G +I GM++G+ GMCVGE+R+IT+P  +AYGE G    IP  + LVF V +L++    D
Sbjct:  155 KPPSCPRTIQVSDFVRYHYNGTFLD-GTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITVPPFLAYGEEGDGKDIPGQASLVFDVALLDLHNPKD 258          

HSP 3 Score: 86.6557 bits (213), Expect = 1.332e-19
Identity = 39/101 (38.61%), Postives = 62/101 (61.39%), Query Frame = 3
Query:  207 KSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEIL 509
            K PDCS  +   DY+ YHY  +  + G   DS+++ G+ Y   +  G+V+ GM+ G++ MCVGE+R + IP  + YGE G    +P  + LVF +E+LE++
Sbjct:  378 KPPDCSVLSKKGDYLKYHYNASLLD-GTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELV 477          

HSP 4 Score: 83.5741 bits (205), Expect = 1.765e-18
Identity = 42/102 (41.18%), Postives = 62/102 (60.78%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +C  ++ S D++ YHY GT  + G  FDSSY R   +   I +G VI GM+EG+ G+C+GERR I +P  + YGE+G    IP  + LVF + +++    SD
Sbjct:  270 NCERRSQSGDFLRYHYNGTLLD-GTLFDSSYSRNHTFDTYIGQGYVIPGMDEGLLGVCIGERRRIVVPPHLGYGEKGRGS-IPGSAVLVFDIHVIDFHNPSD 369          
BLAST of Peptidylprolyl isomerase vs. Ensembl Mouse
Match: Fkbp10 (FK506 binding protein 10 [Source:MGI Symbol;Acc:MGI:104769])

HSP 1 Score: 95.1301 bits (235), Expect = 1.238e-22
Identity = 46/117 (39.32%), Postives = 69/117 (58.97%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N+   +QS I+ + P C     + D+V YHY GT  + G  FD+SY R   Y   + +G +I GM++G++G C+GERR IT+P  +AYGE G    IP  + L+F V +++    SD
Sbjct:  150 NKADTVQSTILLRPPYCPRMVQNSDFVRYHYNGTLLD-GTAFDNSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFHNPSD 265          

HSP 2 Score: 93.5893 bits (231), Expect = 4.451e-22
Identity = 45/101 (44.55%), Postives = 62/101 (61.39%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            C  +    D+V YHY GTF E+G KFDSSYDR       +  G +I GM+ G+ GMCV ERR + +P  + YG  G + +IPPD+ L F V +L++  K+D
Sbjct:   54 CPREVQMGDFVRYHYNGTF-EDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPDATLYFDVVLLDVWNKAD 153          

HSP 3 Score: 70.0922 bits (170), Expect = 8.087e-14
Identity = 35/95 (36.84%), Postives = 59/95 (62.11%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEML 500
            +C+  +   D++ YHY  +  + G +  SS+D   P   T+   +VIEG++ G++GMCVGERR + +P  +A+GE G   V P  + L+F+VE++
Sbjct:  278 NCNETSKIGDFIRYHYNCSLLD-GTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARGV-PGSAVLLFEVELV 370          
BLAST of Peptidylprolyl isomerase vs. UniProt/SwissProt
Match: sp|P0CP96|FKBP2_CRYNJ (FK506-binding protein 2 OS=Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) OX=214684 GN=FPR2 PE=3 SV=1)

HSP 1 Score: 122.094 bits (305), Expect = 1.635e-34
Identity = 57/127 (44.88%), Postives = 86/127 (67.72%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            L++  + +L+ + + + +E   I V   P+ C  K+   D +S HY GT  ++G KFDSS DR +P+ FT+  G+VI+G ++G+  MC+ E+R +TIPS +AYGERG+ PVIPP S LVF+VE+L I
Sbjct:    7 LIIALLFSLSLILAAKSAEQLQIGVKYVPEECPVKSRKGDRLSMHYTGTLAKDGSKFDSSLDRNRPFEFTLGAGQVIKGWDQGLLDMCISEKRKLTIPSHLAYGERGHPPVIPPQSTLVFEVELLGI 133          
BLAST of Peptidylprolyl isomerase vs. UniProt/SwissProt
Match: sp|P0CP97|FKBP2_CRYNB (FK506-binding protein 2 OS=Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) OX=283643 GN=FPR2 PE=3 SV=1)

HSP 1 Score: 122.094 bits (305), Expect = 2.167e-34
Identity = 57/127 (44.88%), Postives = 85/127 (66.93%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            L++  +  L+ + + + +E   I V   P+ C  K+   D +S HY GT  ++G KFDSS DR +P+ FT+  G+VI+G ++G+  MC+ E+R +TIPS +AYGERG+ PVIPP S LVF+VE+L I
Sbjct:    7 LIIALLFTLSLILAAKSAEQLQIGVKYVPEECPVKSRKGDRLSMHYTGTLAKDGSKFDSSLDRNRPFEFTLGAGQVIKGWDQGLLDMCISEKRKLTIPSHLAYGERGHPPVIPPQSTLVFEVELLGI 133          
BLAST of Peptidylprolyl isomerase vs. UniProt/SwissProt
Match: sp|P32472|FKBP2_YEAST (Peptidyl-prolyl cis-trans isomerase FPR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=FPR2 PE=1 SV=1)

HSP 1 Score: 119.783 bits (299), Expect = 1.490e-33
Identity = 57/131 (43.51%), Postives = 83/131 (63.36%), Query Frame = 3
Query:  120 QIFLVLFAVLALTNVESNQISELQSIIVNKSP--DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
             +F +   V   + + +  +S+L+  I+ + P  DC  KA   D V  HY G+  E+G  FDSSY RG P  F +  G VI+G ++G+ GMCVGE+R + IPS++AYGERG   VIPP +DLVF VE++++
Sbjct:    1 MMFNIYLFVTFFSTILAGSLSDLEIGIIKRIPVEDCLIKAMPGDKVKVHYTGSLLESGTVFDSSYSRGSPIAFELGVGRVIKGWDQGVAGMCVGEKRKLQIPSSLAYGERGVPGVIPPSADLVFDVELVDV 131          
BLAST of Peptidylprolyl isomerase vs. UniProt/SwissProt
Match: sp|P0C1J5|FKB2B_RHIO9 (FK506-binding protein 2B OS=Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) OX=246409 GN=FKBP3 PE=3 SV=1)

HSP 1 Score: 119.398 bits (298), Expect = 1.415e-32
Identity = 58/135 (42.96%), Postives = 87/135 (64.44%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTNVES--NQISELQSIIVNKSP--DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            M+   L L   +  T+V +     ++LQ  +  + P  +C+ K+ S D +S HY GT ++ G+KFDSS DR +P+ FT+  G+VI+G ++G+ GMCVGE+R + IP  + YGERG   VIP  + LVF+VE+LEI
Sbjct:    1 MRFSLLALLGTIVATSVSALKEPPTQLQVGVKKRIPASECTRKSHSGDELSMHYTGTLFDTGEKFDSSLDRNEPFVFTLGAGQVIQGWDQGLLGMCVGEKRRLVIPPHLGYGERGAGGVIPGGATLVFEVELLEI 135          
BLAST of Peptidylprolyl isomerase vs. UniProt/SwissProt
Match: sp|Q6CUZ8|FKBP2_KLULA (FK506-binding protein 2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) OX=284590 GN=FPR2 PE=3 SV=1)

HSP 1 Score: 116.316 bits (290), Expect = 3.143e-32
Identity = 55/130 (42.31%), Postives = 84/130 (64.62%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKS 518
            ++LF VL    V + +++EL   +  +  DC  KA   D VS HY G   ++G+ FDSSY+RG P +F +   +VI G ++GI GMC+GE R + IPS + YG RG   VIPPD+DL+F+ E+++I +++
Sbjct:    9 VLLFFVL---QVFAEKLTELVVGVTKEPVDCKIKASKGDVVSVHYTGKLRDSGEIFDSSYNRGVPIQFKLGYSQVISGWDQGILGMCIGEGRTLHIPSELGYGSRGAGSVIPPDADLIFETELVDIQREA 135          
BLAST of Peptidylprolyl isomerase vs. TrEMBL
Match: A0A0C3FG04 (Peptidylprolyl isomerase OS=Piloderma croceum F 1598 OX=765440 GN=PILCRDRAFT_819588 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 2.182e-37
Identity = 65/137 (47.45%), Postives = 91/137 (66.42%), Query Frame = 3
Query:  120 QIF-----LVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKK 515
            QIF     ++L AV AL + +    +EL+  + +   DC AKA + D +  HY GT   NGDKFDSS DRGQP   T+  G+VI+G ++G++GMC+ E+R++TIPS MAYG RG+  VIPP+S LVF VE++ +  K
Sbjct:    2 QIFKYSLSILLLAVSALADAKVEPPTELKIDVTHLPSDCPAKARTGDSIQVHYTGTLLANGDKFDSSRDRGQPLPLTLGVGQVIKGWDDGLQGMCLHEKRILTIPSGMAYGPRGFGSVIPPNSALVFDVELVGLESK 138          
BLAST of Peptidylprolyl isomerase vs. TrEMBL
Match: A0A067NKD5 (Peptidylprolyl isomerase OS=Pleurotus ostreatus PC15 OX=1137138 GN=PLEOSDRAFT_40162 PE=4 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 4.467e-35
Identity = 57/101 (56.44%), Postives = 75/101 (74.26%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKS 518
            DCS KA S D V  HY GT +  GDKFDSS+DRGQP   T+  G+VI+G +EG++GMCV ERR +TIP+ MAYG RG+  +IPP+S LVF+VE++ +  K+
Sbjct:   36 DCSVKAKSGDGVRVHYTGTLFATGDKFDSSHDRGQPLPLTLGVGQVIQGWDEGLQGMCVNERRTLTIPANMAYGSRGFGSIIPPNSALVFEVELVGLDSKA 136          
BLAST of Peptidylprolyl isomerase vs. TrEMBL
Match: F8PV69 (Peptidylprolyl isomerase OS=Serpula lacrymans var. lacrymans (strain S7.3) OX=936435 GN=SERLA73DRAFT_52281 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 1.092e-34
Identity = 57/114 (50.00%), Postives = 80/114 (70.18%), Query Frame = 3
Query:  180 SELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +ELQ+ +     +CS KA + D +  HY GT + NG+KFDSS DRG P    +  G+VI+G +EG++GMC+ E+RV+TIP+ MAYG RG+  VIPP+S LVF VE++ + KK D
Sbjct:   21 TELQTQVTYLPEECSTKAQTGDAIKVHYTGTLFANGNKFDSSLDRGSPLAIKLGVGQVIKGWDEGLQGMCLNEKRVLTIPAKMAYGTRGFGSVIPPNSALVFDVELVGLEKKHD 134          
BLAST of Peptidylprolyl isomerase vs. TrEMBL
Match: F8NV74 (Peptidylprolyl isomerase OS=Serpula lacrymans var. lacrymans (strain S7.9) OX=578457 GN=SERLADRAFT_348593 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 1.092e-34
Identity = 57/114 (50.00%), Postives = 80/114 (70.18%), Query Frame = 3
Query:  180 SELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +ELQ+ +     +CS KA + D +  HY GT + NG+KFDSS DRG P    +  G+VI+G +EG++GMC+ E+RV+TIP+ MAYG RG+  VIPP+S LVF VE++ + KK D
Sbjct:   21 TELQTQVTYLPEECSTKAQTGDAIKVHYTGTLFANGNKFDSSLDRGSPLAIKLGVGQVIKGWDEGLQGMCLNEKRVLTIPAKMAYGTRGFGSVIPPNSALVFDVELVGLEKKHD 134          
BLAST of Peptidylprolyl isomerase vs. TrEMBL
Match: A0A0C3CPE4 (Peptidylprolyl isomerase OS=Hebeloma cylindrosporum h7 OX=686832 GN=M413DRAFT_442292 PE=4 SV=1)

HSP 1 Score: 128.642 bits (322), Expect = 1.412e-34
Identity = 63/131 (48.09%), Postives = 83/131 (63.36%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTNVESNQI--SELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEML 500
            M +    LFA  A+   ES ++  +ELQ         C  KA   D +  HY GT + NG+KFDSS DRGQP   T+  G+VI+G +EG+KGMC+ E+R +TIPS MAYG RG+  VIPP+S LVF VE++
Sbjct:    1 MFKWLTTLFAAGAVAAHESGKVAPTELQIETTFMPAVCGVKAQKGDQIKVHYTGTLFTNGNKFDSSLDRGQPLPLTLGVGQVIKGWDEGLKGMCLNEKRKLTIPSHMAYGSRGFGSVIPPNSALVFTVELV 131          
BLAST of Peptidylprolyl isomerase vs. Ensembl Cavefish
Match: fkbp2 (FKBP prolyl isomerase 2 [Source:NCBI gene;Acc:103047465])

HSP 1 Score: 106.301 bits (264), Expect = 3.303e-29
Identity = 53/138 (38.41%), Postives = 84/138 (60.87%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTN--VESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            MK   L+   +++L    V   +  +LQ  I  +  +C  K+   D ++ HY G   E+G +FDSS  R QP+ FT+  G+VI+G ++G+ GMC GE+R + IPS + YG+RG  P IP  + L+F+VE+L I +++D
Sbjct:    1 MKLYILLAVTLISLLTEVVHGAEKKKLQIGIKKRVDNCPIKSRKGDVLNMHYTGKL-EDGTEFDSSIPRNQPFTFTLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRGAPPKIPGGATLIFEVELLSIERRAD 137          
BLAST of Peptidylprolyl isomerase vs. Ensembl Cavefish
Match: fkbp9 (peptidyl-prolyl cis-trans isomerase FKBP9-like [Source:NCBI gene;Acc:103029066])

HSP 1 Score: 106.301 bits (264), Expect = 1.692e-26
Identity = 58/139 (41.73%), Postives = 79/139 (56.83%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTNVESNQISELQSIIVNKS--PD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +K IFL     L   N        L  I+V K+  P+ C     + D+V YHY G F  +G KFDSSYDRG  Y   + RG++I GM++ + GMCV +R ++ IP  +AYG+ GY  +IPPDS L F V +L+I    D
Sbjct:    7 LKMIFLAFMVGLVACNAPP---VPLDDIVVEKTFTPERCERAVQTGDFVRYHYNGMF-PDGKKFDSSYDRGTTYNVFVGRGQLIAGMDKALLGMCVNQRSLVKIPPQLAYGKNGYGDIIPPDSILHFDVLLLDIWNSDD 141          

HSP 2 Score: 92.0485 bits (227), Expect = 1.342e-21
Identity = 48/101 (47.52%), Postives = 63/101 (62.38%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            CS K+   D++ YHY GT  + G  FDSSY R + Y   I +G VI GM++G+ G+CVGERR ITIP  +AYGE G    IP  + LVF V +++    SD
Sbjct:  266 CSRKSKEGDFMRYHYNGTLLD-GTFFDSSYSRNRTYDTYIGKGYVIAGMDQGLLGVCVGERRKITIPPHLAYGEEGTGTKIPGSAVLVFDVHIIDFHNPSD 365          

HSP 3 Score: 89.7373 bits (221), Expect = 1.016e-20
Identity = 50/131 (38.17%), Postives = 74/131 (56.49%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            ++ F VL L    S+   ++Q+   +K   C       DYV YHY GT  + G  FDSS+ R + Y   +  G +I GM++G+ GMCVGE+R+IT+P ++ YGE G    IP  + LVF V +L++    D
Sbjct:  126 ILHFDVLLLDIWNSDDKVQIQT--YHKPETCGRTVQVSDYVRYHYNGTLLD-GTLFDSSHTRMRTYDTYVGIGWLIAGMDQGLLGMCVGEKRIITMPPSLGYGEHGDGSDIPAQASLVFDVVLLDLHNPKD 253          

HSP 4 Score: 78.9518 bits (193), Expect = 6.160e-17
Identity = 39/115 (33.91%), Postives = 62/115 (53.91%), Query Frame = 3
Query:  162 VESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            ++ +  S+   I   K   C+      D++ YHY  +  + G   DSS+  G+ Y   +  G+VI GM EG+  MCVGE+RV+ +P  + YGERG    +P  + LVF +E+  +
Sbjct:  358 IDFHNPSDTVQITSEKPEHCNYTTKRGDFIKYHYNASLLD-GTYIDSSHKYGKTYDVVLGAGQVIPGMEEGLLEMCVGEKRVLVVPPHLGYGERGVDGEVPGSAVLVFNIELFGV 471          
BLAST of Peptidylprolyl isomerase vs. Ensembl Cavefish
Match: fkbp10a (peptidyl-prolyl cis-trans isomerase FKBP10-like [Source:NCBI gene;Acc:103034004])

HSP 1 Score: 101.293 bits (251), Expect = 8.371e-25
Identity = 51/102 (50.00%), Postives = 66/102 (64.71%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTID-RGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            C+ +    DYV YHY GTF  NG KFDSS D+G P+   +    +VI G++ G+ GMCV ERR ITIP  +AYG  G   VIPPD+ LVF V +L++  +SD
Sbjct:   35 CAREVQQGDYVRYHYTGTF-TNGTKFDSSLDKGAPFMGQVGLESKVIPGLDRGVLGMCVNERRKITIPPYLAYGVSGAGSVIPPDTTLVFDVLLLDVWNESD 135          

HSP 2 Score: 96.2857 bits (238), Expect = 5.064e-23
Identity = 53/132 (40.15%), Postives = 77/132 (58.33%), Query Frame = 3
Query:  132 VLFAVLALT--NVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            V+F VL +   NV+ +   E+Q +       C  K+ + DY+ YHY GTF ++G  FDSSY R   Y   I  G VI GM+  ++G+CVGERR +TIP  +AYGE G   +IP  + L+F + +++    SD
Sbjct:  233 VIFDVLLVDVFNVKDDLQVEVQDV----PQSCRRKSQAGDYIRYHYNGTF-QDGTLFDSSYQRNHTYNTYIGLGHVIAGMDRALQGVCVGERRRVTIPPHLAYGENGTGSLIPGSAVLIFDLHIIDFHNPSD 359          

HSP 3 Score: 88.5817 bits (218), Expect = 2.298e-20
Identity = 46/130 (35.38%), Postives = 75/130 (57.69%), Query Frame = 3
Query:  132 VLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            ++F VL L     +  ++ +++   +S  C       D+V YHY G+   NG  FDSSY R   Y   + +G++I+GM+EG+ GMC+ ERR I IP  +AYGE+GY   +P  + ++F V ++++    D
Sbjct:  121 LVFDVLLLDVWNESDKADSRTLFRPQS--CRRSVQRSDFVRYHYNGSLL-NGTVFDSSYWRNSTYDTYVGQGDLIKGMDEGLLGMCISERRSIIIPPFLAYGEKGYGSKVPAYATVIFDVLLVDVFNVKD 247          

HSP 4 Score: 71.633 bits (174), Expect = 1.951e-14
Identity = 38/106 (35.85%), Postives = 63/106 (59.43%), Query Frame = 3
Query:  144 VLALTNVESNQISELQSIIVNKSP-DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPV 458
            +  L  ++ +  S+   I V +SP DCS    + D+++Y Y  +  + G +  SS D  +P + T+ +G+VIEG+ +G++GMCVGERR + IP    +G+ G S V
Sbjct:  346 IFDLHIIDFHNPSDQVDIRVTRSPPDCSTTGTANDFITYRYNCSLLD-GTRLYSSDDYAKPPQVTLGQGKVIEGLEKGLQGMCVGERREVIIPPHFGHGQNGGSGV 450          
BLAST of Peptidylprolyl isomerase vs. Ensembl Cavefish
Match: fkbp10a (peptidyl-prolyl cis-trans isomerase FKBP10-like [Source:NCBI gene;Acc:103034004])

HSP 1 Score: 100.908 bits (250), Expect = 1.056e-24
Identity = 51/102 (50.00%), Postives = 66/102 (64.71%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTID-RGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            C+ +    DYV YHY GTF  NG KFDSS D+G P+   +    +VI G++ G+ GMCV ERR ITIP  +AYG  G   VIPPD+ LVF V +L++  +SD
Sbjct:   35 CAREVQQGDYVRYHYTGTF-TNGTKFDSSLDKGAPFMGQVGLESKVIPGLDRGVLGMCVNERRKITIPPYLAYGVSGAGSVIPPDTTLVFDVLLLDVWNESD 135          

HSP 2 Score: 95.9005 bits (237), Expect = 7.557e-23
Identity = 53/132 (40.15%), Postives = 77/132 (58.33%), Query Frame = 3
Query:  132 VLFAVLALT--NVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            V+F VL +   NV+ +   E+Q +       C  K+ + DY+ YHY GTF ++G  FDSSY R   Y   I  G VI GM+  ++G+CVGERR +TIP  +AYGE G   +IP  + L+F + +++    SD
Sbjct:  233 VIFDVLLVDVFNVKDDLQVEVQDV----PQSCRRKSQAGDYIRYHYNGTF-QDGTLFDSSYQRNHTYNTYIGLGHVIAGMDRALQGVCVGERRRVTIPPHLAYGENGTGSLIPGSAVLIFDLHIIDFHNPSD 359          

HSP 3 Score: 88.1965 bits (217), Expect = 3.504e-20
Identity = 46/130 (35.38%), Postives = 75/130 (57.69%), Query Frame = 3
Query:  132 VLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            ++F VL L     +  ++ +++   +S  C       D+V YHY G+   NG  FDSSY R   Y   + +G++I+GM+EG+ GMC+ ERR I IP  +AYGE+GY   +P  + ++F V ++++    D
Sbjct:  121 LVFDVLLLDVWNESDKADSRTLFRPQS--CRRSVQRSDFVRYHYNGSLL-NGTVFDSSYWRNSTYDTYVGQGDLIKGMDEGLLGMCISERRSIIIPPFLAYGEKGYGSKVPAYATVIFDVLLVDVFNVKD 247          

HSP 4 Score: 71.633 bits (174), Expect = 2.016e-14
Identity = 38/106 (35.85%), Postives = 63/106 (59.43%), Query Frame = 3
Query:  144 VLALTNVESNQISELQSIIVNKSP-DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPV 458
            +  L  ++ +  S+   I V +SP DCS    + D+++Y Y  +  + G +  SS D  +P + T+ +G+VIEG+ +G++GMCVGERR + IP    +G+ G S V
Sbjct:  346 IFDLHIIDFHNPSDQVDIRVTRSPPDCSTTGTANDFITYRYNCSLLD-GTRLYSSDDYAKPPQVTLGQGKVIEGLEKGLQGMCVGERREVIIPPHFGHGQNGGSGV 450          
BLAST of Peptidylprolyl isomerase vs. Ensembl Cavefish
Match: fkbp7 (FKBP prolyl isomerase 7 [Source:ZFIN;Acc:ZDB-GENE-030616-182])

HSP 1 Score: 93.9745 bits (232), Expect = 1.234e-23
Identity = 48/131 (36.64%), Postives = 79/131 (60.31%), Query Frame = 3
Query:  126 FLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKF--DSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILK 512
            F   F+     +V  + +   Q  +V K  +CS K+   D ++ HY G   ++G +F    S  RG+P+ F +  GEVI+G++ G+K MC GE+R IT+P ++A+G +G  PV PP+S ++F+VE+L I +
Sbjct:   21 FFCCFSGFICADVSGDSV---QIQVVFKPENCSQKSKRGDLLNAHYDGFLQQDGSQFYCSRSAKRGEPHWFVLGVGEVIKGLDLGLKDMCPGEKRKITVPPSLAFGAQGKHPV-PPNSTVIFEVELLHIRR 147          
BLAST of Peptidylprolyl isomerase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004854.1 (pep scaffold:Pmarinus_7.0:GL501075:9618:21951:-1 gene:ENSPMAG00000004388.1 transcript:ENSPMAT00000004854.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 104.76 bits (260), Expect = 2.607e-29
Identity = 49/130 (37.69%), Postives = 80/130 (61.54%), Query Frame = 3
Query:  132 VLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            VL  +L  +   +    +LQ  +  ++  C  K+   D +  HY GT  E+G +FDSS  R QP+ FT+  G+VI+G ++G+ GMC GE+R + IP  + YG+RG  P IP  + LVF+VE+L++ ++++
Sbjct:   14 VLLCLLQGSAWATEGKKKLQIGVKKRADSCPIKSRKGDTLHMHYTGTL-EDGTEFDSSIPRNQPFIFTLGTGQVIKGWDQGLLGMCEGEKRKLVIPPELGYGDRGAPPKIPGGATLVFEVELLQVERRAE 142          
BLAST of Peptidylprolyl isomerase vs. Ensembl Sea Lamprey
Match: fkbp1b (FKBP prolyl isomerase 1B [Source:ZFIN;Acc:ZDB-GENE-040426-1785])

HSP 1 Score: 86.6557 bits (213), Expect = 5.101e-23
Identity = 42/81 (51.85%), Postives = 57/81 (70.37%), Query Frame = 3
Query:  264 VGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            VGTF  NG KFDSS DR +P+RFT+ + +VI+G  EG+  M +G R  IT    MAYGE G+  VIPP++ L+F VE+L++
Sbjct:    1 VGTF-RNGKKFDSSRDRKKPFRFTLGKQQVIKGWEEGVGQMSLGMRARITCTPDMAYGETGHPGVIPPNTTLIFDVELLQL 80          
BLAST of Peptidylprolyl isomerase vs. Ensembl Sea Lamprey
Match: fkbp9 (FKBP prolyl isomerase 9 [Source:ZFIN;Acc:ZDB-GENE-040801-23])

HSP 1 Score: 89.3521 bits (220), Expect = 2.367e-21
Identity = 43/82 (52.44%), Postives = 51/82 (62.20%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIP 464
            C  K  S DYV YHY GT  + G  FDSSY R   Y   +  G +I GM++G+ GMCV ERR +TIP  + YGE GY PVIP
Sbjct:   86 CERKVQSTDYVRYHYNGTLLD-GTPFDSSYTRKSTYNTYVGMGWLIAGMDQGLLGMCVNERRFVTIPPQLGYGESGYDPVIP 166          

HSP 2 Score: 84.3445 bits (207), Expect = 1.163e-19
Identity = 43/102 (42.16%), Postives = 60/102 (58.82%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            +C+ K  S DYV YHY GT  + G  FDSS+ R + Y   +  G +I GM EG+  MCV ERR++TIP  + YGE G +  IP  + LVF + +++     D
Sbjct:  197 NCTRKTKSSDYVRYHYNGTLLD-GTPFDSSHSRNRTYNTYLGLGNIIAGMEEGLLDMCVNERRIVTIPPHLGYGEGG-TGSIPGSAVLVFDINLIDFHNPKD 296          

HSP 3 Score: 76.6406 bits (187), Expect = 6.014e-17
Identity = 39/112 (34.82%), Postives = 63/112 (56.25%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            N   E+Q+    +  +C  K+   D V  HY GT Y +G   DSS+  G+ Y   +  G V+ G+++ + GMCVGE+R+  IP  + YGE+G    +P  + LVF +E++ +
Sbjct:  293 NPKDEVQTDSYFRPEECFRKSRKGDLVQVHYNGT-YMDGSPLDSSHKYGKTYDLILGSGRVVLGLDQALTGMCVGEKRLAIIPPHLGYGEQGIDGDVPGSAVLVFDLELVAL 403          

HSP 4 Score: 63.1586 bits (152), Expect = 2.434e-12
Identity = 26/73 (35.62%), Postives = 45/73 (61.64%), Query Frame = 3
Query:  303 SYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            SYD+G  Y   + +  ++ GM++G+ GMCV E R I +P+A+ YG+ G    IP +++L F V ++++    D
Sbjct:    1 SYDKGSTYNMFVGKKLMVAGMDQGLLGMCVNELRTIRVPAALGYGKEGLGDSIPANAELFFSVLLVDVWNPED 73          
BLAST of Peptidylprolyl isomerase vs. Ensembl Sea Lamprey
Match: fkbp1aa (FKBP prolyl isomerase 1Aa [Source:ZFIN;Acc:ZDB-GENE-030131-7275])

HSP 1 Score: 82.8037 bits (203), Expect = 5.965e-21
Identity = 41/86 (47.67%), Postives = 55/86 (63.95%), Query Frame = 3
Query:  249 VSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            V  HY GT  E+G KFDSS DR +P++F I + EVI G  EG+  M VG+R  +T     AYG  G+  VIPP++ L+F VE+L +
Sbjct:   48 VVVHYTGTL-EDGKKFDSSRDRDKPFKFKIGKQEVIRGWEEGVAQMSVGQRARLTCSPDFAYGAIGHPGVIPPNATLLFDVELLRL 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Sea Lamprey
Match: fkbp11 (FKBP prolyl isomerase 11 [Source:ZFIN;Acc:ZDB-GENE-030616-357])

HSP 1 Score: 82.4185 bits (202), Expect = 3.722e-20
Identity = 41/112 (36.61%), Postives = 65/112 (58.04%), Query Frame = 3
Query:  180 SELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKK 515
            +EL   +V+K  +C   +   D +  HY G   ++G  FD+S  R  P +  + + +VI G  +G+ GMCVGE+R + IP  +AYG+RG  P IP D+ L F+ E++ +  K
Sbjct:   29 AELLVEVVHKPAECVELSAQGDTLHVHYTGRL-KDGSVFDTSAMR-DPLQVELGKKQVIPGWEQGLLGMCVGEKRKLVIPPHLAYGKRGAPPSIPADAVLTFETELVSLRHK 138          
BLAST of Peptidylprolyl isomerase vs. Ensembl Yeast
Match: FPR2 (Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2 [Source:SGD;Acc:S000002927])

HSP 1 Score: 119.783 bits (299), Expect = 2.146e-35
Identity = 57/131 (43.51%), Postives = 83/131 (63.36%), Query Frame = 3
Query:  120 QIFLVLFAVLALTNVESNQISELQSIIVNKSP--DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
             +F +   V   + + +  +S+L+  I+ + P  DC  KA   D V  HY G+  E+G  FDSSY RG P  F +  G VI+G ++G+ GMCVGE+R + IPS++AYGERG   VIPP +DLVF VE++++
Sbjct:    1 MMFNIYLFVTFFSTILAGSLSDLEIGIIKRIPVEDCLIKAMPGDKVKVHYTGSLLESGTVFDSSYSRGSPIAFELGVGRVIKGWDQGVAGMCVGEKRKLQIPSSLAYGERGVPGVIPPSADLVFDVELVDV 131          
BLAST of Peptidylprolyl isomerase vs. Ensembl Yeast
Match: FPR1 (Peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A [Source:SGD;Acc:S000005079])

HSP 1 Score: 95.1301 bits (235), Expect = 4.008e-26
Identity = 47/97 (48.45%), Postives = 64/97 (65.98%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            D +    + D V+ HY GT  ENG KFDSS DRG P++  I  G+VI+G + GI  + VGE+  +TIP   AYG RG+  +IPP+S LVF VE+L++
Sbjct:   18 DGATFPKTGDLVTIHYTGTL-ENGQKFDSSVDRGSPFQCNIGVGQVIKGWDVGIPKLSVGEKARLTIPGPYAYGPRGFPGLIPPNSTLVFDVELLKV 113          
BLAST of Peptidylprolyl isomerase vs. Ensembl Yeast
Match: FPR4 (Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers [Source:SGD;Acc:S000004441])

HSP 1 Score: 65.4698 bits (158), Expect = 2.448e-13
Identity = 40/107 (37.38%), Postives = 64/107 (59.81%), Query Frame = 3
Query:  186 LQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            ++  +  K P   AK G++  V   YVG   +NG  FD +  +G+P+ F + +GEVI+G + G+ GM VG  R I IP+  AYG++   P IP +S+L F V+++ +
Sbjct:  292 IEDRVTGKGP--HAKKGTR--VGMRYVGKL-KNGKVFDKNT-KGKPFVFKLGQGEVIKGWDIGVAGMAVGGERRIVIPAPYAYGKQAL-PGIPANSELTFDVKLVSM 391          
BLAST of Peptidylprolyl isomerase vs. Ensembl Yeast
Match: FPR3 (Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication [Source:SGD;Acc:S000004539])

HSP 1 Score: 65.0846 bits (157), Expect = 3.568e-13
Identity = 38/94 (40.43%), Postives = 58/94 (61.70%), Query Frame = 3
Query:  225 AKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            AK G++  V   Y+G   +NG  FD +   G+P+ F + RGEVI+G + G+ GM VG  R I IP+  AYG++   P IP +S+L F V+++ +
Sbjct:  321 AKRGAR--VGMRYIGKL-KNGKVFDKNTS-GKPFAFKLGRGEVIKGWDIGVAGMSVGGERRIIIPAPYAYGKQAL-PGIPANSELTFDVKLVSM 409          
BLAST of Peptidylprolyl isomerase vs. Ensembl Nematostella
Match: EDO40282 (Peptidyl-prolyl cis-trans isomerase [Source:UniProtKB/TrEMBL;Acc:A7S7R3])

HSP 1 Score: 115.546 bits (288), Expect = 2.189e-33
Identity = 56/131 (42.75%), Postives = 83/131 (63.36%), Query Frame = 3
Query:  129 LVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            LVL  V A +  E  ++++LQ  +  K  DC  ++   D +  HY G   E+G +FDSS  RG+P+ FT+  G+VI+G ++G+  MC GE+R + IPS M YG+RG  P IP  + L+F+VE+L+I  KSD
Sbjct:    1 LVLSLVTASSAAEKKKVTKLQIGVKKKVKDCKRRSVKGDSLHMHYTGKL-EDGTEFDSSIPRGEPFVFTLGTGQVIKGWDQGLLNMCAGEKRKLVIPSDMGYGDRGAPPKIPGGATLIFEVELLKIGDKSD 130          
BLAST of Peptidylprolyl isomerase vs. Ensembl Nematostella
Match: EDO47498 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLX5])

HSP 1 Score: 107.842 bits (268), Expect = 1.921e-29
Identity = 56/131 (42.75%), Postives = 79/131 (60.31%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            M  + +V F+ LAL   E     EL+  +V+K   C+ K    D +S HY G    NG+KFDSS DRG+ + FT+ +G VI+G  +G+  MC+GE+R +TIP  +AYGE G    IPP + L   VE++EI
Sbjct:    5 MNLLAIVAFSGLALGAEEPK--GELKIEVVSKPEKCTRKTHVGDTLSMHYTGRLA-NGNKFDSSLDRGKTFDFTLGKGMVIQGWEQGLLDMCIGEKRKLTIPPHLAYGENGAGAAIPPHATLYMDVELVEI 132          
BLAST of Peptidylprolyl isomerase vs. Ensembl Nematostella
Match: EDO34576 (Peptidyl-prolyl cis-trans isomerase [Source:UniProtKB/TrEMBL;Acc:A7SNX5])

HSP 1 Score: 78.5666 bits (192), Expect = 1.345e-19
Identity = 39/84 (46.43%), Postives = 53/84 (63.10%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRG-QPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIP 464
            +C  +A + D V+ HY G+  ENG  FDSS  +G +P  F + +G VI+G  EGIKGMC+GE+R + IP  + YG  G   VIP
Sbjct:    5 NCQGEAQTGDIVAVHYTGSL-ENGRMFDSSVHQGRKPIEFELGKGRVIKGWEEGIKGMCIGEKRKLIIPPHLGYGANGVDNVIP 87          
BLAST of Peptidylprolyl isomerase vs. Ensembl Nematostella
Match: EDO34418 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPD7])

HSP 1 Score: 81.6481 bits (200), Expect = 1.488e-19
Identity = 41/102 (40.20%), Postives = 64/102 (62.75%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRG---QPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILK 512
            DC  K    D+V  HY G + ++G  FD++ D     QP+ FTI  G VI+G  +G+ GMCVG++R I IP A+AYG++G S  +P ++ L + +E+ ++ K
Sbjct:   13 DCENKTKVGDHVVVHYTG-WMQDGSLFDTTRDHRKGYQPFEFTIGGGTVIKGFEQGVTGMCVGQKRKIVIPPALAYGKKG-SGDVPANTTLTYNLELFDVRK 112          
BLAST of Peptidylprolyl isomerase vs. Ensembl Nematostella
Match: EDO31332 (Peptidyl-prolyl cis-trans isomerase [Source:UniProtKB/TrEMBL;Acc:A7SY88])

HSP 1 Score: 70.8626 bits (172), Expect = 1.780e-16
Identity = 36/79 (45.57%), Postives = 50/79 (63.29%), Query Frame = 3
Query:  228 KAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIP 464
            KAG    VS HY GT   +G KFDSS DRG+P++F +  G+VI+G +EG+  M +G++  +T     AYG +GY  V P
Sbjct:   18 KAGQT--VSVHYTGTL-TDGKKFDSSRDRGKPFQFKLGAGQVIKGWDEGVAQMSLGQKATLTCTPDYAYGPKGYPGVYP 93          
BLAST of Peptidylprolyl isomerase vs. Ensembl Medaka
Match: fkbp2 (FKBP prolyl isomerase 2 [Source:ZFIN;Acc:ZDB-GENE-040912-126])

HSP 1 Score: 109.768 bits (273), Expect = 3.828e-30
Identity = 54/144 (37.50%), Postives = 88/144 (61.11%), Query Frame = 3
Query:   96 NLYFLGMKQIFLVLFAVLALTNVESNQI--SELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N +   M+ ++LV  A L+L+    N     +LQ  I  +  +C  K+   D ++ HY G   E+G +FDSS  R +P+ FT+  G+VI+G ++G+ GMC GE+R + IP+ + YG+RG  P IP  + L+F+VE+L I ++S+
Sbjct:   29 NYFLFFMRALWLVAVAALSLSPAAVNGADKKKLQIGIKKRVDNCPIKSRKGDVLNMHYTGKL-EDGTEFDSSIPRDRPFTFTLGTGQVIKGWDQGLLGMCEGEKRKLVIPAELGYGDRGAPPKIPGGATLIFEVELLSIERRSE 171          
BLAST of Peptidylprolyl isomerase vs. Ensembl Medaka
Match: fkbp10a (FKBP prolyl isomerase 10 [Source:NCBI gene;Acc:101169948])

HSP 1 Score: 114.775 bits (286), Expect = 7.423e-30
Identity = 58/135 (42.96%), Postives = 85/135 (62.96%), Query Frame = 3
Query:  117 KQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            K + L++F V A+T + SN + ++     +    C  +  ++D+V YH+ GTFYENG +FDSS+DRG+ +   +  G +I GM+ G+ GMCV ERR IT+P  +AYG  G   VIPPDS LV+ V +L+I    D
Sbjct:    5 KPLELLIF-VCAVTRISSNPLVDIVVDRYHIPRVCPREVQTEDFVRYHFNGTFYENGKQFDSSHDRGKAFISQVGLGRLITGMDRGLLGMCVSERRRITVPPHLAYGSIGAGGVIPPDSVLVYDVHLLDIWNPED 138          

HSP 2 Score: 87.8113 bits (216), Expect = 3.939e-20
Identity = 43/117 (36.75%), Postives = 69/117 (58.97%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N   ++Q   ++K   CS  A + D+V YHY G+   + + FDSSY R   Y   I  G VI+GM++ ++G+C+GE+R I IP  +AYGE+G   +IP  + L+F + +++     D
Sbjct:  135 NPEDKVQIRTLSKPAGCSRGASASDFVRYHYNGSLLTD-EAFDSSYQRNGTYNTYIGMGHVIQGMDKALQGLCMGEKRRIGIPPHLAYGEKGVGGLIPGSAVLIFHIHVIDFHNPKD 250          

HSP 3 Score: 61.6178 bits (148), Expect = 4.797e-11
Identity = 34/97 (35.05%), Postives = 51/97 (52.58%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYV-----GTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERG 446
            N    +Q  I +K  DC+A + + D + Y Y      GT   + D +DS      P   T+   +VI G+ +G++GMCVGERR + +P   A+GE G
Sbjct:  247 NPKDSVQIRITHKPRDCNATSEADDLIKYRYNCSLMDGTLLYSSDHYDS------PSVTTLGANKVIVGLEDGLRGMCVGERREVVVPPHWAHGENG 337          
BLAST of Peptidylprolyl isomerase vs. Ensembl Medaka
Match: fkbp10a (FKBP prolyl isomerase 10 [Source:NCBI gene;Acc:101169948])

HSP 1 Score: 114.775 bits (286), Expect = 1.585e-29
Identity = 58/135 (42.96%), Postives = 85/135 (62.96%), Query Frame = 3
Query:  117 KQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            K + L++F V A+T + SN + ++     +    C  +  ++D+V YH+ GTFYENG +FDSS+DRG+ +   +  G +I GM+ G+ GMCV ERR IT+P  +AYG  G   VIPPDS LV+ V +L+I    D
Sbjct:    5 KPLELLIF-VCAVTRISSNPLVDIVVDRYHIPRVCPREVQTEDFVRYHFNGTFYENGKQFDSSHDRGKAFISQVGLGRLITGMDRGLLGMCVSERRRITVPPHLAYGSIGAGGVIPPDSVLVYDVHLLDIWNPED 138          

HSP 2 Score: 97.0561 bits (240), Expect = 2.832e-23
Identity = 47/117 (40.17%), Postives = 72/117 (61.54%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            N   ++Q   ++K   CS  A + D+V YHY G+   + + FDS Y   + Y   + +G++I+G+ EG+ G CVGERRVI +P  +AYGE+GY   IPP + LVF+V M+++    D
Sbjct:  135 NPEDKVQIRTLSKPAGCSRGASASDFVRYHYNGSLLTD-EAFDSRYSSNETYDTYLGQGDLIKGLEEGLLGTCVGERRVIIVPPFLAYGEQGYGAEIPPQATLVFEVLMVDLFNPKD 250          

HSP 3 Score: 88.1965 bits (217), Expect = 3.389e-20
Identity = 42/101 (41.58%), Postives = 63/101 (62.38%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            C+ +    DYV YHY GTF ++G  FDSSY R   Y   I  G VI+GM++ ++G+C+GE+R I IP  +AYGE+G   +IP  + L+F + +++     D
Sbjct:  263 CTRRTVVGDYVRYHYNGTF-QDGTLFDSSYQRNGTYNTYIGMGHVIQGMDKALQGLCMGEKRRIGIPPHLAYGEKGVGGLIPGSAVLIFHIHVIDFHNPKD 362          

HSP 4 Score: 61.6178 bits (148), Expect = 5.506e-11
Identity = 34/97 (35.05%), Postives = 51/97 (52.58%), Query Frame = 3
Query:  171 NQISELQSIIVNKSPDCSAKAGSQDYVSYHYV-----GTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERG 446
            N    +Q  I +K  DC+A + + D + Y Y      GT   + D +DS      P   T+   +VI G+ +G++GMCVGERR + +P   A+GE G
Sbjct:  359 NPKDSVQIRITHKPRDCNATSEADDLIKYRYNCSLMDGTLLYSSDHYDS------PSVTTLGANKVIVGLEDGLRGMCVGERREVVVPPHWAHGENG 449          
BLAST of Peptidylprolyl isomerase vs. Ensembl Medaka
Match: fkbp9 (peptidyl-prolyl cis-trans isomerase FKBP9 [Source:NCBI gene;Acc:101157467])

HSP 1 Score: 106.301 bits (264), Expect = 1.301e-26
Identity = 54/132 (40.91%), Postives = 77/132 (58.33%), Query Frame = 3
Query:  126 FLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            FLV FA      V  + +   ++ +  K   C       D+V YHY+G F  +G KFDSSYDRG  Y   + + ++IEGM+  + GMC+ ERR+I IP  +AYG++GY  +IPPDS L F V +L++    D
Sbjct:   13 FLVTFAACDAPPVPLDDLVIEKTFVPEK---CVRAVKVGDFVRYHYIGMF-PDGKKFDSSYDRGSTYNVFVGKKQLIEGMDRALVGMCINERRLIKIPPELAYGKQGYGEIIPPDSILHFDVLLLDVWNPED 140          

HSP 2 Score: 88.1965 bits (217), Expect = 3.012e-20
Identity = 45/101 (44.55%), Postives = 62/101 (61.39%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            CS K    D+V YHY GT  + G  FDSS+ R + Y   +  G +I GM++G+ GMCVGERR+IT+P ++ YGE G    IP  + LVF V +L++    D
Sbjct:  153 CSRKVEVSDFVRYHYNGTLLD-GTLFDSSHTRMRTYDTYVGIGWLIAGMDQGLLGMCVGERRIITMPPSLGYGENGDGSDIPGQASLVFDVVLLDLHNPKD 252          

HSP 3 Score: 88.1965 bits (217), Expect = 3.516e-20
Identity = 45/101 (44.55%), Postives = 61/101 (60.40%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            CS K  + D+V YH+ G+  + G  FDSSY R + Y   + RG VI GM+E + G+CVGERR ITIP  + YGE G    IP  + LVF + +++    SD
Sbjct:  265 CSRKTVAGDFVRYHFNGSLLD-GTFFDSSYSRNRTYDTYVGRGYVIAGMDEALIGVCVGERRSITIPPHLGYGEEGTGTKIPGSAVLVFDIHIIDFHNPSD 364          

HSP 4 Score: 77.0258 bits (188), Expect = 2.485e-16
Identity = 39/122 (31.97%), Postives = 66/122 (54.10%), Query Frame = 3
Query:  144 VLALTNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            V  +  ++ +  S+   + V   P  C       D+V YHY  +  + G   DS+Y+ G+ Y   +   +V+ GM +G+  MCVGE+R I IP  + YGERG +  +P  + LVF +E++++
Sbjct:  351 VFDIHIIDFHNPSDKTKVTVTFKPQVCEKLTKKGDFVKYHYNASLMD-GTSIDSTYNYGKTYNIVLGANQVVPGMEDGLLDMCVGEKRHIVIPPHLGYGERGVTGEVPGSAVLVFDIELIDM 471          
BLAST of Peptidylprolyl isomerase vs. Ensembl Medaka
Match: fkbp9 (peptidyl-prolyl cis-trans isomerase FKBP9 [Source:NCBI gene;Acc:101157467])

HSP 1 Score: 105.916 bits (263), Expect = 1.868e-26
Identity = 54/132 (40.91%), Postives = 77/132 (58.33%), Query Frame = 3
Query:  126 FLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            FLV FA      V  + +   ++ +  K   C       D+V YHY+G F  +G KFDSSYDRG  Y   + + ++IEGM+  + GMC+ ERR+I IP  +AYG++GY  +IPPDS L F V +L++    D
Sbjct:   13 FLVTFAACDAPPVPLDDLVIEKTFVPEK---CVRAVKVGDFVRYHYIGMF-PDGKKFDSSYDRGSTYNVFVGKKQLIEGMDRALVGMCINERRLIKIPPELAYGKQGYGEIIPPDSILHFDVLLLDVWNPED 140          

HSP 2 Score: 88.1965 bits (217), Expect = 3.632e-20
Identity = 45/101 (44.55%), Postives = 62/101 (61.39%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            CS K    D+V YHY GT  + G  FDSS+ R + Y   +  G +I GM++G+ GMCVGERR+IT+P ++ YGE G    IP  + LVF V +L++    D
Sbjct:  153 CSRKVEVSDFVRYHYNGTLLD-GTLFDSSHTRMRTYDTYVGIGWLIAGMDQGLLGMCVGERRIITMPPSLGYGENGDGSDIPGQASLVFDVVLLDLHNPKD 252          

HSP 3 Score: 87.8113 bits (216), Expect = 4.196e-20
Identity = 45/101 (44.55%), Postives = 61/101 (60.40%), Query Frame = 3
Query:  219 CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            CS K  + D+V YH+ G+  + G  FDSSY R + Y   + RG VI GM+E + G+CVGERR ITIP  + YGE G    IP  + LVF + +++    SD
Sbjct:  265 CSRKTVAGDFVRYHFNGSLLD-GTFFDSSYSRNRTYDTYVGRGYVIAGMDEALIGVCVGERRSITIPPHLGYGEEGTGTKIPGSAVLVFDIHIIDFHNPSD 364          

HSP 4 Score: 77.0258 bits (188), Expect = 2.776e-16
Identity = 39/122 (31.97%), Postives = 66/122 (54.10%), Query Frame = 3
Query:  144 VLALTNVESNQISELQSIIVNKSPD-CSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            V  +  ++ +  S+   + V   P  C       D+V YHY  +  + G   DS+Y+ G+ Y   +   +V+ GM +G+  MCVGE+R I IP  + YGERG +  +P  + LVF +E++++
Sbjct:  351 VFDIHIIDFHNPSDKTKVTVTFKPQVCEKLTKKGDFVKYHYNASLMD-GTSIDSTYNYGKTYNIVLGANQVVPGMEDGLLDMCVGEKRHIVIPPHLGYGERGVTGEVPGSAVLVFDIELIDM 471          
BLAST of Peptidylprolyl isomerase vs. Planmine SMEST
Match: SMESG000011025.1 (SMESG000011025.1)

HSP 1 Score: 280.796 bits (717), Expect = 3.559e-98
Identity = 136/136 (100.00%), Postives = 136/136 (100.00%), Query Frame = 3
Query:  114 MKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            MKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD
Sbjct:    1 MKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 136          
BLAST of Peptidylprolyl isomerase vs. Planmine SMEST
Match: SMESG000026974.1 (SMESG000026974.1)

HSP 1 Score: 128.257 bits (321), Expect = 5.571e-38
Identity = 62/141 (43.97%), Postives = 92/141 (65.25%), Query Frame = 3
Query:  105 FLGMKQIFLVLFAVLALTNVESNQ--ISELQSIIVNKSPDCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSD 521
            FL      ++LF ++     +S +  I+EL+  I  +  DC+ KA   D +  HY GT Y++G KFDSS DRG P +FT+  G+VI+G + GI+GMCVGE+R + IPS + YG+ G  P IPP + LVF+VE+++I K+S+
Sbjct:    3 FLAFSISIILLFQIVYSEESKSTKKPINELRIGIKKRINDCTEKAKDGDMIHMHYTGTLYDDGSKFDSSLDRGDPLKFTLGTGQVIKGWDLGIQGMCVGEKRKLFIPSHLGYGDNGSPPKIPPKATLVFEVELMKIEKRSE 143          
BLAST of Peptidylprolyl isomerase vs. Planmine SMEST
Match: SMESG000062712.1 (SMESG000062712.1)

HSP 1 Score: 85.5001 bits (210), Expect = 1.204e-21
Identity = 43/96 (44.79%), Postives = 59/96 (61.46%), Query Frame = 3
Query:  216 DCSAKAGSQDYVSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLE 503
            DC         V+ HYVGT   NG KFDSS DR +P++F I  G VI+G +EG+  M  GE+  +T     AYG +GY  +IPP+S LVF+V +++
Sbjct:   12 DCVNYPKVGQNVTVHYVGTL-TNGKKFDSSRDRNEPFKFKIGTGSVIKGWDEGVLKMSKGEKAKLTCSPDYAYGSKGYPGLIPPNSTLVFEVLLID 106          
BLAST of Peptidylprolyl isomerase vs. Planmine SMEST
Match: SMESG000028286.1 (SMESG000028286.1)

HSP 1 Score: 83.5741 bits (205), Expect = 6.767e-21
Identity = 42/86 (48.84%), Postives = 54/86 (62.79%), Query Frame = 3
Query:  249 VSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            V  HY GT   NG KFDSS DR +P +F I  GEVI+G +EG+  + +GER  +T     AYG  G   VIPP+S L+F VE++ I
Sbjct:   23 VEVHYTGTL-TNGKKFDSSRDRNRPLKFKIGMGEVIKGWDEGVAQLSLGERAKLTCSPDYAYGSEGIQDVIPPNSVLIFDVELISI 107          
BLAST of Peptidylprolyl isomerase vs. Planmine SMEST
Match: SMESG000004790.1 (SMESG000004790.1)

HSP 1 Score: 83.5741 bits (205), Expect = 6.767e-21
Identity = 42/86 (48.84%), Postives = 54/86 (62.79%), Query Frame = 3
Query:  249 VSYHYVGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVITIPSAMAYGERGYSPVIPPDSDLVFQVEMLEI 506
            V  HY GT   NG KFDSS DR +P +F I  GEVI+G +EG+  + +GER  +T     AYG  G   VIPP+S L+F VE++ I
Sbjct:   23 VEVHYTGTL-TNGKKFDSSRDRNRPLKFKIGMGEVIKGWDEGVAQLSLGERAKLTCSPDYAYGSEGIQDVIPPNSVLIFDVELISI 107          
The following BLAST results are available for this feature:
BLAST of Peptidylprolyl isomerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FKBP26.054e-2837.14FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HG... [more]
FKBP26.054e-2837.14FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HG... [more]
FKBP26.054e-2837.14FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HG... [more]
AP001453.56.054e-2837.14Uncharacterized protein LOC114841035 [Source:NCBI ... [more]
FKBP21.012e-2737.14FKBP prolyl isomerase 2 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fkb-12.420e-2839.85Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL... [more]
fkb-12.420e-2839.85Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL... [more]
fkb-12.420e-2839.85Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL... [more]
fkb-24.118e-2446.39Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL... [more]
fkb-15.559e-2349.40Peptidylprolyl isomerase [Source:UniProtKB/TrEMBL... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fkbp141.359e-2845.83gene:FBgn0010470 transcript:FBtr0342897[more]
Fkbp141.359e-2845.83gene:FBgn0010470 transcript:FBtr0071703[more]
Fkbp141.359e-2845.83gene:FBgn0010470 transcript:FBtr0342896[more]
Fkbp141.359e-2845.83gene:FBgn0010470 transcript:FBtr0300397[more]
Fkbp141.478e-2845.83gene:FBgn0010470 transcript:FBtr0306013[more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fkbp29.270e-3038.35FKBP prolyl isomerase 2 [Source:ZFIN;Acc:ZDB-GENE-... [more]
fkbp94.472e-2742.45FKBP prolyl isomerase 9 [Source:ZFIN;Acc:ZDB-GENE-... [more]
fkbp1b1.553e-2249.40FKBP prolyl isomerase 1B [Source:ZFIN;Acc:ZDB-GENE... [more]
fkbp10b2.402e-2242.57FKBP prolyl isomerase 10b [Source:ZFIN;Acc:ZDB-GEN... [more]
fkbp73.725e-2234.75FKBP prolyl isomerase 7 [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fkbp29.607e-2939.39FKBP prolyl isomerase 2 [Source:NCBI gene;Acc:1001... [more]
fkbp93.764e-2640.56FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:1001... [more]
fkbp94.046e-2640.56FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:1001... [more]
fkbp98.879e-2641.01FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:1001... [more]
fkbp99.391e-2640.71FKBP prolyl isomerase 9 [Source:NCBI gene;Acc:1001... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fkbp22.667e-2839.69FK506 binding protein 2 [Source:MGI Symbol;Acc:MGI... [more]
Fkbp22.667e-2839.69FK506 binding protein 2 [Source:MGI Symbol;Acc:MGI... [more]
Fkbp101.476e-2544.44FK506 binding protein 10 [Source:MGI Symbol;Acc:MG... [more]
Fkbp91.575e-2548.70FK506 binding protein 9 [Source:MGI Symbol;Acc:MGI... [more]
Fkbp101.238e-2239.32FK506 binding protein 10 [Source:MGI Symbol;Acc:MG... [more]
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BLAST of Peptidylprolyl isomerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P0CP96|FKBP2_CRYNJ1.635e-3444.88FK506-binding protein 2 OS=Cryptococcus neoformans... [more]
sp|P0CP97|FKBP2_CRYNB2.167e-3444.88FK506-binding protein 2 OS=Cryptococcus neoformans... [more]
sp|P32472|FKBP2_YEAST1.490e-3343.51Peptidyl-prolyl cis-trans isomerase FPR2 OS=Saccha... [more]
sp|P0C1J5|FKB2B_RHIO91.415e-3242.96FK506-binding protein 2B OS=Rhizopus delemar (stra... [more]
sp|Q6CUZ8|FKBP2_KLULA3.143e-3242.31FK506-binding protein 2 OS=Kluyveromyces lactis (s... [more]
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BLAST of Peptidylprolyl isomerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0C3FG042.182e-3747.45Peptidylprolyl isomerase OS=Piloderma croceum F 15... [more]
A0A067NKD54.467e-3556.44Peptidylprolyl isomerase OS=Pleurotus ostreatus PC... [more]
F8PV691.092e-3450.00Peptidylprolyl isomerase OS=Serpula lacrymans var.... [more]
F8NV741.092e-3450.00Peptidylprolyl isomerase OS=Serpula lacrymans var.... [more]
A0A0C3CPE41.412e-3448.09Peptidylprolyl isomerase OS=Hebeloma cylindrosporu... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fkbp23.303e-2938.41FKBP prolyl isomerase 2 [Source:NCBI gene;Acc:1030... [more]
fkbp91.692e-2641.73peptidyl-prolyl cis-trans isomerase FKBP9-like [So... [more]
fkbp10a8.371e-2550.00peptidyl-prolyl cis-trans isomerase FKBP10-like [S... [more]
fkbp10a1.056e-2450.00peptidyl-prolyl cis-trans isomerase FKBP10-like [S... [more]
fkbp71.234e-2336.64FKBP prolyl isomerase 7 [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000004854.12.607e-2937.69pep scaffold:Pmarinus_7.0:GL501075:9618:21951:-1 g... [more]
fkbp1b5.101e-2351.85FKBP prolyl isomerase 1B [Source:ZFIN;Acc:ZDB-GENE... [more]
fkbp92.367e-2152.44FKBP prolyl isomerase 9 [Source:ZFIN;Acc:ZDB-GENE-... [more]
fkbp1aa5.965e-2147.67FKBP prolyl isomerase 1Aa [Source:ZFIN;Acc:ZDB-GEN... [more]
fkbp113.722e-2036.61FKBP prolyl isomerase 11 [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
FPR22.146e-3543.51Membrane-bound peptidyl-prolyl cis-trans isomerase... [more]
FPR14.008e-2648.45Peptidyl-prolyl cis-trans isomerase (PPIase); bind... [more]
FPR42.448e-1337.38Peptidyl-prolyl cis-trans isomerase (PPIase); nucl... [more]
FPR33.568e-1340.43Nucleolar peptidyl-prolyl cis-trans isomerase (PPI... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO402822.189e-3342.75Peptidyl-prolyl cis-trans isomerase [Source:UniPr... [more]
EDO474981.921e-2942.75Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO345761.345e-1946.43Peptidyl-prolyl cis-trans isomerase [Source:UniPr... [more]
EDO344181.488e-1940.20Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO313321.780e-1645.57Peptidyl-prolyl cis-trans isomerase [Source:UniPr... [more]
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BLAST of Peptidylprolyl isomerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fkbp23.828e-3037.50FKBP prolyl isomerase 2 [Source:ZFIN;Acc:ZDB-GENE-... [more]
fkbp10a7.423e-3042.96FKBP prolyl isomerase 10 [Source:NCBI gene;Acc:101... [more]
fkbp10a1.585e-2942.96FKBP prolyl isomerase 10 [Source:NCBI gene;Acc:101... [more]
fkbp91.301e-2640.91peptidyl-prolyl cis-trans isomerase FKBP9 [Source:... [more]
fkbp91.868e-2640.91peptidyl-prolyl cis-trans isomerase FKBP9 [Source:... [more]
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BLAST of Peptidylprolyl isomerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000011025.13.559e-98100.00SMESG000011025.1[more]
SMESG000026974.15.571e-3843.97SMESG000026974.1[more]
SMESG000062712.11.204e-2144.79SMESG000062712.1[more]
SMESG000028286.16.767e-2148.84SMESG000028286.1[more]
SMESG000004790.16.767e-2148.84SMESG000004790.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003871 ID=SMED30003871|Name=Peptidylprolyl isomerase|organism=Schmidtea mediterranea sexual|type=transcript|length=588bp
TGAAATTACAATTTTAATCGTCAAATCTAGTGTGTTGTATCAACACAGGA
ATTGTGTGCGAGTTTCTCGTCAAATATATTGGTGTAGGAATTAATAATTT
GTATTTCCTAGGAATGAAGCAAATATTTCTAGTGCTATTTGCAGTGCTGG
CATTAACTAATGTGGAATCGAATCAGATCTCGGAGCTCCAGTCGATTATC
GTAAACAAGTCTCCTGATTGTTCTGCTAAGGCTGGATCCCAAGATTATGT
TTCATATCATTATGTTGGAACGTTTTATGAAAACGGTGACAAATTCGATA
GTAGCTACGACAGAGGCCAGCCGTATAGATTCACAATTGACAGAGGGGAA
GTGATCGAAGGAATGAATGAAGGAATAAAAGGAATGTGCGTTGGCGAAAG
ACGCGTAATTACGATTCCATCGGCCATGGCCTATGGTGAACGTGGCTATT
CACCAGTAATTCCGCCAGATTCAGATCTCGTTTTTCAAGTGGAAATGTTA
GAGATCTTGAAAAAATCGGATTTATAAACACTTACAGCAACTTTTTTTAT
TTATATAATATAATTTTTTAAAATTCTTTTCAATACGG
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protein sequence of SMED30003871-orf-1

>SMED30003871-orf-1 ID=SMED30003871-orf-1|Name=SMED30003871-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=138bp
MKQIFLVLFAVLALTNVESNQISELQSIIVNKSPDCSAKAGSQDYVSYHY
VGTFYENGDKFDSSYDRGQPYRFTIDRGEVIEGMNEGIKGMCVGERRVIT
IPSAMAYGERGYSPVIPPDSDLVFQVEMLEILKKSDL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR001179PPIase_FKBP_dom
Vocabulary: biological process
TermDefinition
GO:0006457protein folding
GO:0000413protein peptidyl-prolyl isomerization
Vocabulary: molecular function
TermDefinition
GO:0003755peptidyl-prolyl cis-trans isomerase activity
GO:0016853isomerase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001179FKBP-type peptidyl-prolyl cis-trans isomerase domainPFAMPF00254FKBP_Ccoord: 39..129
e-value: 1.3E-30
score: 105.6
IPR001179FKBP-type peptidyl-prolyl cis-trans isomerase domainPROSITEPS50059FKBP_PPIASEcoord: 43..132
score: 27.417
NoneNo IPR availableGENE3DG3DSA:3.10.50.40coord: 14..136
e-value: 4.1E-38
score: 132.1
NoneNo IPR availablePANTHERPTHR45779FAMILY NOT NAMEDcoord: 6..135
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..19
score: 0.838
NoneNo IPR availableSUPERFAMILYSSF54534FKBP-likecoord: 14..135