GTP-binding protein GEM

Overview
NameGTP-binding protein GEM
Smed IDSMED30003820
Length (bp)1188
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of GTP-binding protein GEM (SMED30003820) t-SNE clustered cells

Violin plots show distribution of expression levels for GTP-binding protein GEM (SMED30003820) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GTP-binding protein GEM (SMED30003820) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GTP-binding protein GEM (SMED30003820) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30003820

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
prepharyngeal regionSMED30003820h1SMcG0003388 SmedASXL_012022SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
cephalic gangliaSMED30003820h1SMcG0003388 dd_Smed_v4_7051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30003820h1SMcG0003388 dd_Smed_v4_7051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30003820h1SMcG0003388 dd_Smed_v4_7051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30003820h1SMcG0003388 OX_Smed_1.0.04912ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Human
Match: GEM (GTP binding protein overexpressed in skeletal muscle [Source:HGNC Symbol;Acc:HGNC:4234])

HSP 1 Score: 81.2629 bits (199), Expect = 1.282e-16
Identity = 63/203 (31.03%), Postives = 97/203 (47.78%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQF-------------LTSETYGFYSNMDAPDKTIRQVTVDL----DDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F             L  +TY     +D    TI  + +D+     +NEW   LHD         +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K K+S P
Sbjct:   74 TYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVDGESATI--ILLDMWENKGENEW---LHD------HCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRKESMP 263
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Human
Match: GEM (GTP binding protein overexpressed in skeletal muscle [Source:HGNC Symbol;Acc:HGNC:4234])

HSP 1 Score: 81.2629 bits (199), Expect = 1.282e-16
Identity = 63/203 (31.03%), Postives = 97/203 (47.78%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQF-------------LTSETYGFYSNMDAPDKTIRQVTVDL----DDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F             L  +TY     +D    TI  + +D+     +NEW   LHD         +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K K+S P
Sbjct:   74 TYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVDGESATI--ILLDMWENKGENEW---LHD------HCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRKESMP 263
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Human
Match: RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator [Source:HGNC Symbol;Acc:HGNC:10446])

HSP 1 Score: 81.2629 bits (199), Expect = 1.601e-16
Identity = 53/170 (31.18%), Postives = 85/170 (50.00%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD----LDDNEWTLVLHDLDN------ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
             + V ++G  GVGK+AL   F   E        D P+      T D    +D  E +L+++D+        +        DAY+IVYS+ DK SF+  +++   L  +  T    I +V  KSDL R R+VS ++G+  A ++D +FIE S  L+H +  L   ++ +IR
Sbjct:   91 VYKVLLLGAPGVGKSALARIFGGVE--------DGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 252
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Human
Match: RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator [Source:HGNC Symbol;Acc:HGNC:10446])

HSP 1 Score: 81.2629 bits (199), Expect = 1.601e-16
Identity = 53/170 (31.18%), Postives = 85/170 (50.00%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD----LDDNEWTLVLHDLDN------ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
             + V ++G  GVGK+AL   F   E        D P+      T D    +D  E +L+++D+        +        DAY+IVYS+ DK SF+  +++   L  +  T    I +V  KSDL R R+VS ++G+  A ++D +FIE S  L+H +  L   ++ +IR
Sbjct:   91 VYKVLLLGAPGVGKSALARIFGGVE--------DGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 252
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Human
Match: RIT1 (Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023])

HSP 1 Score: 73.559 bits (179), Expect = 1.707e-14
Identity = 55/193 (28.50%), Postives = 93/193 (48.19%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESPDAY-------IIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKK--LRKAKDSKTNYSMKHKKSTP 1096
            + + ++G  GVGK+A+  QF++   + F  + D   +   ++ + +DD    L + D       F    D Y       II YSI D+ SF    +  Q +     T  + + +V  KSDL++LRQV+ E+G  LA  +   F E S    + ID++   ++ +IRR +K+  L   K SK   S+  +  +P
Sbjct:   22 YKLVMLGAGGVGKSAMTMQFIS---HRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVREIRRKEKEAVLAMEKKSKPKNSVWKRLKSP 211
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Celegans
Match: Y52B11A.4 (pep chromosome:WBcel235:I:10979802:11004283:-1 gene:WBGene00013124.1 transcript:Y52B11A.4.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y52B11A.4)

HSP 1 Score: 61.2326 bits (147), Expect = 5.256e-10
Identity = 61/250 (24.40%), Postives = 114/250 (45.60%), Query Frame = 2 
Query:  311 RIRSFKRTHKG-VINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYN---NNDKXXXXXXXXXXXXDLL----VPQNINEQKKEIKT--TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTF-EESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
            R+R FK   KG V+++GD+ +           R+ ++   ++P  +    + D +  S  E   S  L+        +NE      +  T+ ++V+G  G GK++L  Q +TSE    ++  D        V++ +   E  LV  + D     +      A+++VYSI+ K S+      L+ + +   T      +   K DLER R V+ ++ +   +    E  E+S  L+H +D+LLV ++ +I+
Sbjct:  157 RVRQFKIDEKGAVVSRGDSFRR---------KRTPTYKSDKSPSPFPVSVSTDSARGSRSESEASEPLISDDVAKMTVNEMTNASTSHKTYKIYVVGDTGTGKSSLISQLITSEYKNAFA--DEIQDYENTVSICIGGVECDLVFFESDMSDPCWLTNEIHAFLVVYSIDSKSSWKQAMVALEMIRDRPGTRNLPTLVAGNKIDLERKRTVTKQEVRAAKAAMGFEHFEISVALDHDVDDLLVGLVAEIQ 395
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Celegans
Match: Y52B11A.4 (pep chromosome:WBcel235:I:10979607:11004283:-1 gene:WBGene00013124.1 transcript:Y52B11A.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y52B11A.4)

HSP 1 Score: 61.2326 bits (147), Expect = 5.256e-10
Identity = 61/250 (24.40%), Postives = 114/250 (45.60%), Query Frame = 2 
Query:  311 RIRSFKRTHKG-VINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYN---NNDKXXXXXXXXXXXXDLL----VPQNINEQKKEIKT--TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTF-EESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
            R+R FK   KG V+++GD+ +           R+ ++   ++P  +    + D +  S  E   S  L+        +NE      +  T+ ++V+G  G GK++L  Q +TSE    ++  D        V++ +   E  LV  + D     +      A+++VYSI+ K S+      L+ + +   T      +   K DLER R V+ ++ +   +    E  E+S  L+H +D+LLV ++ +I+
Sbjct:  157 RVRQFKIDEKGAVVSRGDSFRR---------KRTPTYKSDKSPSPFPVSVSTDSARGSRSESEASEPLISDDVAKMTVNEMTNASTSHKTYKIYVVGDTGTGKSSLISQLITSEYKNAFA--DEIQDYENTVSICIGGVECDLVFFESDMSDPCWLTNEIHAFLVVYSIDSKSSWKQAMVALEMIRDRPGTRNLPTLVAGNKIDLERKRTVTKQEVRAAKAAMGFEHFEISVALDHDVDDLLVGLVAEIQ 395
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Celegans
Match: ral-1 (RAL (Ras-related GTPase) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N3F8])

HSP 1 Score: 57.7658 bits (138), Expect = 1.642e-9
Identity = 44/165 (26.67%), Postives = 77/165 (46.67%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEW----TLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLE---SLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
            V ++G  GVGK+AL  QF+  E    Y    A D   ++V +D ++       T    D   I   +  S + +I V+SI D +SF+   +  + +L    S S+  I +V  K D+   R VS E  ++ A  +   ++E S      +D +   ++ +++R K
Sbjct:   20 VIMVGTGGVGKSALTLQFMYDEFVEEYEPTKA-DSYRKKVVLDGEECSIDILDTAGQEDYSAIRDNYYRSGEGFICVFSILDMESFEATNEFREQILRVKNSDSSVPIVLVGNKGDMRDQRVVSAELCRQRAEQWGCHYVETSAKRRENVDKVFYDLMREMKRRK 183
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Celegans
Match: ral-1 (RAL (Ras-related GTPase) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N3F8])

HSP 1 Score: 57.3806 bits (137), Expect = 3.527e-9
Identity = 44/165 (26.67%), Postives = 77/165 (46.67%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEW----TLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLE---SLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
            V ++G  GVGK+AL  QF+  E    Y    A D   ++V +D ++       T    D   I   +  S + +I V+SI D +SF+   +  + +L    S S+  I +V  K D+   R VS E  ++ A  +   ++E S      +D +   ++ +++R K
Sbjct:   61 VIMVGTGGVGKSALTLQFMYDEFVEEYEPTKA-DSYRKKVVLDGEECSIDILDTAGQEDYSAIRDNYYRSGEGFICVFSILDMESFEATNEFREQILRVKNSDSSVPIVLVGNKGDMRDQRVVSAELCRQRAEQWGCHYVETSAKRRENVDKVFYDLMREMKRRK 224
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Celegans
Match: rab-8 (RAB family; Rab8 [Source:UniProtKB/TrEMBL;Acc:G5EFC1])

HSP 1 Score: 56.6102 bits (135), Expect = 4.458e-9
Identity = 45/164 (27.44%), Postives = 78/164 (47.56%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSA-IFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
            F + +IG +GVGKT +  +F        + +    D  IR  T++LD  +  L + D         I+T +       I+VY I ++ SF+     ++N+ E  ++     I+  K D+E  R+VS ++G++LA  Y  +F+E S   N  ID     +   I+
Sbjct:    9 FKLLLIGDSGVGKTCVLFRFSDDSFNNSFISTIGIDFKIR--TIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIILVYDITNERSFENIKNWIRNIEEHAASDVERMIIGNKCDIEERREVSRDRGEQLAIEYGTKFLETSAKANLNIDEAFFTLARDIK 170
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Fly
Match: Rgk1 (gene:FBgn0264753 transcript:FBtr0334282)

HSP 1 Score: 109.768 bits (273), Expect = 6.002e-26
Identity = 86/294 (29.25%), Postives = 139/294 (47.28%), Query Frame = 2 
Query:  242 GETNNLLSNEDNERISEK-----ESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQ-----KKEIKTT------FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEES-----PDAYIIVYSIEDKDSFDWCTQVLQNLL--ESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKD 1054
            G  N L   +   R++       E   YR+R F  T KGV+N+GD++K+    S N    S S T+                    +    L  P +++ +      +E  T+      + V ++G   VGK++L  QF+TSE    Y      +   + V+V L   E  L+  D      T +E      P  Y ++YS  D+ SF    QVLQ L   ++++  A+ +V+ K+DL R R V+ E+GK +A+ YD +FIE S  +NH +D LLV ++++IR   +   K++D
Sbjct:  139 GRPNQLCLPQQRSRVASMPNTGVEEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSVASSNSSTE------------------HLTTQQQLSAPASVSARTSLASSRESSTSNPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDDESGEKAVSVLLSGEESELIFIDHGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLKLENPEKSRD 414
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Fly
Match: Rgk2 (gene:FBgn0085419 transcript:FBtr0112633)

HSP 1 Score: 107.842 bits (268), Expect = 4.825e-25
Identity = 87/276 (31.52%), Postives = 135/276 (48.91%), Query Frame = 2 
Query:  305 LYRIRSFKRTHKGVINQGDTV------KNCSLLSLNLPTRSKSFTKGEN-PYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSE---TYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEES-----PDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKH 1081
            LYR+R F  +   V+N GD++       N S+ S N     +S  +G      Y N D  P              P +           + V ++G  GVGKTAL  QF+TSE   TY    + +  +KT   V+V LDD E  +V  D  ++  + E S     P   ++V+S+ D+ SF    +++  L +   T   A+ +V  K+DL R R ++ ++GK LA+  DA+FIE S+ + H +D LLV I+ ++R  +K+ +KA  SK   S  H
Sbjct:  450 LYRLRHFSISKGNVVNCGDSIISRRSRSNTSVNSTNSRASERSPFEGSCCGAGYANVDSLPA------------TPDDSENLDPPPPARYRVVMLGDAGVGKTALVNQFMTSEYMHTYDASLDDEFGEKT---VSVLLDDEESDMVFIDHPSVEMSVENSLSTYEPHGCVVVFSVVDRSSFRVAEEIINYLWQENYTKDKAVILVGNKADLARARLITSQEGKALAASRDAKFIETSSGIQHNVDELLVGILKQMRLKEKREKKATASKMKTSRTH 710
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Fly
Match: Rgk2 (gene:FBgn0085419 transcript:FBtr0340386)

HSP 1 Score: 107.071 bits (266), Expect = 9.150e-25
Identity = 85/275 (30.91%), Postives = 131/275 (47.64%), Query Frame = 2 
Query:  305 LYRIRSFKRTHKGVINQGDTV------KNCSLLSLNLPTRSKSFTKGEN-PYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTI--RQVTVDLDDNEWTLVLHDLDNISTTFEES-----PDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKH 1081
            LYR+R F  +   V+N GD++       N S+ S N     +S  +G      Y N D  P              P +           + V ++G  GVGKTAL  QF+TSE    Y      D     + V+V LDD E  +V  D  ++  + E S     P   ++V+S+ D+ SF    +++  L +   T   A+ +V  K+DL R R ++ ++GK LA+  DA+FIE S+ + H +D LLV I+ ++R  +K+ +KA  SK   S  H
Sbjct:  450 LYRLRHFSISKGNVVNCGDSIISRRSRSNTSVNSTNSRASERSPFEGSCCGAGYANVDSLPA------------TPDDSENLDPPPPARYRVVMLGDAGVGKTALVNQFMTSEYMHTYDASLVLDDEFGEKTVSVLLDDEESDMVFIDHPSVEMSVENSLSTYEPHGCVVVFSVVDRSSFRVAEEIINYLWQENYTKDKAVILVGNKADLARARLITSQEGKALAASRDAKFIETSSGIQHNVDELLVGILKQMRLKEKREKKATASKMKTSRTH 712
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Fly
Match: Rgk1 (gene:FBgn0264753 transcript:FBtr0334283)

HSP 1 Score: 106.686 bits (265), Expect = 1.516e-24
Identity = 87/294 (29.59%), Postives = 141/294 (47.96%), Query Frame = 2 
Query:  242 GETNNLLSNEDNERISEK-----ESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEE-----SPDAYIIVYSIEDKDSFDWCTQVLQNLL--ESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKK 1087
            G  N L   +   R++       E   YR+R F  T KGV+N+GD++K+    S N    S S T+       +   +  +S+P    +   L     +         + V ++G   VGK++L  QF+TSE    Y      +   + V+V L   E  L+  D      T +E      P  Y ++YS  D+ SF    QVLQ L   ++++  A+ +V+ K+DL R R V+ E+GK +A+ YD +FIE S  +NH +D LLV ++++IR   +   K++D     S++  K
Sbjct: 1020 GRPNQLCLPQQRSRVASMPNTGVEEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSVASSNSSTE-------HLTTQQQLSAPASVSARTSLASSRESSTSNPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDDESGEKAVSVLLSGEESELIFIDHGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLKLENPEKSRDLFRKRSIRKSK 1306
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Fly
Match: Rgk1 (gene:FBgn0264753 transcript:FBtr0334284)

HSP 1 Score: 105.531 bits (262), Expect = 1.997e-24
Identity = 88/310 (28.39%), Postives = 145/310 (46.77%), Query Frame = 2 
Query:  242 GETNNLLSNEDNERISEK-----ESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQ-----KKEIKTT------FDVFVIGKNGVGKTALCEQFLTSE-TYGFYSNMDAPDKTIR---------------QVTVDLDDNEWTLVLHDLDNISTTFEES-----PDAYIIVYSIEDKDSFDWCTQVLQNLL--ESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKD 1054
            G  N L   +   R++       E   YR+R F  T KGV+N+GD++K+    S N    S S T+                    +    L  P +++ +      +E  T+      + V ++G   VGK++L  QF+TSE  + + +++D  +  IR                V+V L   E  L+  D      T +E      P  Y ++YS  D+ SF    QVLQ L   ++++  A+ +V+ K+DL R R V+ E+GK +A+ YD +FIE S  +NH +D LLV ++++IR   +   K++D
Sbjct:  139 GRPNQLCLPQQRSRVASMPNTGVEEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSVASSNSSTE------------------HLTTQQQLSAPASVSARTSLASSRESSTSNPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDLGNCDIRILIEKAADDDESGEKAVSVLLSGEESELIFIDHGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLKLENPEKSRD 430
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Zebrafish
Match: rit1 (Ras-like without CAAX 1 [Source:ZFIN;Acc:ZDB-GENE-070912-329])

HSP 1 Score: 80.1073 bits (196), Expect = 5.030e-17
Identity = 50/182 (27.47%), Postives = 90/182 (49.45%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYS 1072
            + + ++G+ GVGK+A+  QF++   + F  + D   +   +  + +DD    L + D         +   +  + + +II YSI D+ SF       Q +     T  + + +V  KSDL  LRQVS E+GK+LA  +   F E S    + ID +   ++ +IR+H+ ++ +  + KT  S
Sbjct:   14 YKLVMLGEGGVGKSAIIMQFIS---HRFPEDHDPTIEDAYKTQIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIISYSITDRRSFQEARHFKQLIYRVRRTVDTPVVLVGNKSDLVHLRQVSVEEGKQLAREFQCPFFETSAAFRYYIDEVFAALVRQIRQHEAEMVRDSERKTRRS 192
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Zebrafish
Match: rrad (Ras-related associated with diabetes [Source:ZFIN;Acc:ZDB-GENE-030131-5607])

HSP 1 Score: 78.9518 bits (193), Expect = 4.882e-16
Identity = 55/169 (32.54%), Postives = 90/169 (53.25%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
             + V ++G++GVGK++L   F   E     SN           ++ +DD E +++L+D+   DN   +        DAYIIVYS+ DK SF+  +++   L  +  +    I +V  KSDL R R+VS ++G   A ++D +FIE S  L+H + +L   I+ +IR  K
Sbjct:   83 VYKVVLLGEHGVGKSSLARIFGGVED----SNDCEETGNTYDRSLVVDDEETSILLYDIWEQDNSQWLQDQCMRMGDAYIIVYSVTDKSSFEKASELRIQLRRARQSENIPIILVGNKSDLVRSREVSMDEGSACAVVFDCKFIETSASLHHNVRDLFEGIVRQIRLRK 247
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Zebrafish
Match: rrad (Ras-related associated with diabetes [Source:ZFIN;Acc:ZDB-GENE-030131-5607])

HSP 1 Score: 78.9518 bits (193), Expect = 4.882e-16
Identity = 55/169 (32.54%), Postives = 90/169 (53.25%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
             + V ++G++GVGK++L   F   E     SN           ++ +DD E +++L+D+   DN   +        DAYIIVYS+ DK SF+  +++   L  +  +    I +V  KSDL R R+VS ++G   A ++D +FIE S  L+H + +L   I+ +IR  K
Sbjct:   83 VYKVVLLGEHGVGKSSLARIFGGVED----SNDCEETGNTYDRSLVVDDEETSILLYDIWEQDNSQWLQDQCMRMGDAYIIVYSVTDKSSFEKASELRIQLRRARQSENIPIILVGNKSDLVRSREVSMDEGSACAVVFDCKFIETSASLHHNVRDLFEGIVRQIRLRK 247
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Zebrafish
Match: rem2 (RAS (RAD and GEM)-like GTP binding 2 [Source:ZFIN;Acc:ZDB-GENE-081110-1])

HSP 1 Score: 75.8702 bits (185), Expect = 6.426e-15
Identity = 52/174 (29.89%), Postives = 91/174 (52.30%), Query Frame = 2 
Query:  515 NINEQKKEIKTTFDVFVIGKNGVGKT--ALCEQFLTSETYGFYSNMDAPDKT-IRQVTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRH 1027
            ++   +++      + ++G+NGVGK+  ALC   L+  +    S   A D+   R+VTVD D++   LV  +     +T +   +  I+V+S+ D+ SF    Q+   L ESL  + I +V  KSDL R R++S E+    A ++   ++E+S  L+H  ++LL   +   R H
Sbjct:   63 SLKPPQQKYHGPLRIVLLGQNGVGKSSLALCLAGLSDRSLSIDSETQAADEGYPRRVTVD-DEDSSILVYDNWKQELSTLQC--EVCILVFSLTDRRSFHRIAQLRLLLRESLPHTPIILVGNKSDLVRSREISTEEAHSSAMMFGCLYLELSVSLDHRTNDLLEAAVRAARGH 233
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Zebrafish
Match: rem2 (RAS (RAD and GEM)-like GTP binding 2 [Source:ZFIN;Acc:ZDB-GENE-081110-1])

HSP 1 Score: 75.8702 bits (185), Expect = 6.754e-15
Identity = 52/174 (29.89%), Postives = 91/174 (52.30%), Query Frame = 2 
Query:  515 NINEQKKEIKTTFDVFVIGKNGVGKT--ALCEQFLTSETYGFYSNMDAPDKT-IRQVTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRH 1027
            ++   +++      + ++G+NGVGK+  ALC   L+  +    S   A D+   R+VTVD D++   LV  +     +T +   +  I+V+S+ D+ SF    Q+   L ESL  + I +V  KSDL R R++S E+    A ++   ++E+S  L+H  ++LL   +   R H
Sbjct:   66 SLKPPQQKYHGPLRIVLLGQNGVGKSSLALCLAGLSDRSLSIDSETQAADEGYPRRVTVD-DEDSSILVYDNWKQELSTLQC--EVCILVFSLTDRRSFHRIAQLRLLLRESLPHTPIILVGNKSDLVRSREISTEEAHSSAMMFGCLYLELSVSLDHRTNDLLEAAVRAARGH 236
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Xenopus
Match: rem1 (RAS (RAD and GEM)-like GTP-binding 1 [Source:NCBI gene;Acc:100124825])

HSP 1 Score: 81.2629 bits (199), Expect = 8.664e-17
Identity = 70/246 (28.46%), Postives = 117/246 (47.56%), Query Frame = 2 
Query:  386 SLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIR--QVTVDLDDNEWTLVLHDLD--NISTTFE--ESP----DAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKK 1087
            S  LP   ++  +G  P R   +      S   S S+D  V    NE          V ++G  GVGK++L   F   +      + +A ++ +     T+ +D  E TL++ D D  N+    E  +SP    +AYIIVYS+ D+ SF+  +++   L  +       I +V  K+DL R R+VS E+G+  A ++D +FIE S VL H +  L   ++ +IR      R+  D+   + M+ ++
Sbjct:   13 STPLPCAHQNRQRGATPIRKLYSPSKAAGSAHCSGSLDSGVSDGRNE------AHLRVVLLGDPGVGKSSLVAIFRREQ------DREAAEQQLEVFDCTLMVDGKETTLLVMDTDERNMKKAIESSDSPMRLGNAYIIVYSVTDRASFESASELRIQLRRTRQAENIPIILVGNKTDLVRSREVSVEEGRACAVVFDCKFIETSAVLQHNVQELFEGMVRQIRLR----REGADTAEGFRMQSQR 242
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Xenopus
Match: mark4 (MAP/microtubule affinity-regulating kinase 4 [Source:Xenbase;Acc:XB-GENE-6042140])

HSP 1 Score: 80.1073 bits (196), Expect = 2.636e-16
Identity = 56/176 (31.82%), Postives = 89/176 (50.57%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD-------------LDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
             + V ++G++GVGK++L   F   E    +   +A +   R + VD              DDN W   LH+         +  DAY+IVYS+ DK SF+  +++   L  +  +    I +V  KSDL R R+VS E+G+  A ++D +FIE S  L+H + +L   I+ +IR  K
Sbjct:   86 VYKVILLGEHGVGKSSLARIFGGVED--LHDVEEAGNTYDRSIVVDGEEACLLVFDIWEQDDNHW---LHN------QCMKMGDAYVIVYSVTDKASFEKASELRIQLRRARQSEDIPIILVGNKSDLVRSREVSVEEGRACAVVFDCKFIETSASLHHNVKDLFEGIVRQIRLRK 250
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Xenopus
Match: plekhf2 (pleckstrin homology and FYVE domain containing 2 [Source:Xenbase;Acc:XB-GENE-959911])

HSP 1 Score: 79.7221 bits (195), Expect = 3.853e-16
Identity = 61/194 (31.44%), Postives = 98/194 (50.52%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQFL-TSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL------DN-ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F    ++     +M A +   R + VD +    TL+L D+      DN I     +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K ++S P
Sbjct:   77 TYYRVVLIGEQGVGKSTLANIFAGVPDSVDGDCDMLAENTYERNLMVDGESA--TLILIDMWENKAQDNWIREQCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRRESIP 266
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Xenopus
Match: ENSXETT00000051917.1 (RERG/RAS-like [Source:NCBI gene;Acc:100491594])

HSP 1 Score: 71.633 bits (174), Expect = 9.510e-14
Identity = 59/187 (31.55%), Postives = 87/187 (46.52%), Query Frame = 2 
Query:  539 IKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEES----------PDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS------AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTV-LNHMIDNLLVQIITKIRRHKKKLRKA 1048
            +K   ++ V+G +GVGK+AL  +FLT    G Y  ++    +I    V +D  E    + D        EES           D Y++VYSI D+ SF+   Q +Q L+++           I IV  K DL  LR VS E+G+ LA   D +F EVS     H +  +   ++ KIR  K   +K 
Sbjct:   32 LKMEANILVLGADGVGKSALTVRFLTRRFIGEYGELE----SIYSHNVCVDGKEVIFNIWDFPYAKDPTEESCAEEEKRMQWADGYVLVYSICDRASFNVMCQTIQ-LIKTAKDCLGAEKLPIVIVGNKRDLHHLRAVSSEEGRLLALSMDCDFYEVSAAEAYHGVLMVFHGLVDKIRESKLVTKKG 213
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Xenopus
Match: LRP10 (RAS (RAD and GEM)-like GTP binding 2 [Source:NCBI gene;Acc:100488324])

HSP 1 Score: 69.3218 bits (168), Expect = 1.218e-12
Identity = 48/174 (27.59%), Postives = 90/174 (51.72%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL-------DNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS------AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
             + V ++G +GVGK+ L   F   E   F    + P+ T  +  + +D  + TL+++D+         +  +  +  DA+++++S+ D+ +F    Q L +LL  L T+       I +V  K DL R R+V+ E+G+ LA + + ++ E+S  L+H    LL  ++ +IR  K
Sbjct:   72 VYKVMLLGDSGVGKSTLAGIFGGVEDT-FPHGSEHPEDTYER-NLLVDGEKTTLIVYDIWEEAGSQSWMQDSCLQMGDAFLLIFSVTDRSTF----QRLPSLLLQLRTARPHRHIPIILVGNKGDLVRSREVNMEEGRSLAGMLNCKYTEISAALHHNTHELLEGVVRQIRLRK 239
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Mouse
Match: Rem1 (rad and gem related GTP binding protein 1 [Source:MGI Symbol;Acc:MGI:1097696])

HSP 1 Score: 83.1889 bits (204), Expect = 1.610e-17
Identity = 55/204 (26.96%), Postives = 100/204 (49.02%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDN--ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLS 1132
            + V ++G  GVGKT+L   F   +    +  +      + + T+ +D  + TLV+ D      LD      +  ++  AY+IVYSI D+ SF+  +++   L  +   +   I +V  K+DL R R+VS E+G+  A ++D +FIE S  L H +  L   ++ ++R     LR+  ++        ++++ G     F  RL+
Sbjct:   81 YRVVLLGDPGVGKTSLASLFAEKQDRDPHEQLGG----VYERTLSVDGEDTTLVVMDTWEAEKLDESWCQESCLQAGSAYVIVYSIADRSSFESASELRIQLRRTHQANHVPIILVGNKADLARCREVSVEEGRACAVVFDCKFIETSATLQHNVTELFEGVVRQLR-----LRRQDNAAPETPSPRRRASLGQRARRFLARLT 275
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Mouse
Match: Rrad (Ras-related associated with diabetes [Source:MGI Symbol;Acc:MGI:1930943])

HSP 1 Score: 81.2629 bits (199), Expect = 1.026e-16
Identity = 55/170 (32.35%), Postives = 86/170 (50.59%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD----LDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
             + V ++G  GVGK+AL   F   E        D P+      T D    +D  E +L+++D+   D    +        DAY+IVYSI DK SF+  +++   L  +  T    I +V  KSDL R R+VS ++G+  A ++D +FIE S  L+H +  L   ++ +IR
Sbjct:   90 VYKVLLLGAPGVGKSALARIFGGIE--------DGPEAEAAGHTYDRSITVDGEEASLLVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 251
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Mouse
Match: Gem (GTP binding protein (gene overexpressed in skeletal muscle) [Source:MGI Symbol;Acc:MGI:99844])

HSP 1 Score: 80.1073 bits (196), Expect = 2.410e-16
Identity = 62/203 (30.54%), Postives = 97/203 (47.78%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQF-------------LTSETYGFYSNMDAPDKTIRQVTVDL----DDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F             L  +TY     +D    TI  + +D+     +NEW   LHD         +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K ++S P
Sbjct:   73 TYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLVVDGESATI--ILLDMWENKGENEW---LHD------HCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRRESIP 262
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Mouse
Match: Gem (GTP binding protein (gene overexpressed in skeletal muscle) [Source:MGI Symbol;Acc:MGI:99844])

HSP 1 Score: 80.1073 bits (196), Expect = 2.410e-16
Identity = 62/203 (30.54%), Postives = 97/203 (47.78%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQF-------------LTSETYGFYSNMDAPDKTIRQVTVDL----DDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F             L  +TY     +D    TI  + +D+     +NEW   LHD         +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K ++S P
Sbjct:   73 TYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLVVDGESATI--ILLDMWENKGENEW---LHD------HCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRRESIP 262
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Mouse
Match: Rit1 (Ras-like without CAAX 1 [Source:MGI Symbol;Acc:MGI:108053])

HSP 1 Score: 73.9442 bits (180), Expect = 9.498e-15
Identity = 49/180 (27.22%), Postives = 90/180 (50.00%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTN 1066
            + + ++G  GVGK+A+  QF++   + F  + D   +   ++ + +DD    L + D         +   +  + + +II YSI D+ SF    +  Q +     T  + + +V  KSDL++LRQVS E+G  LA  +   F E S    + ID++   ++ +IR+ +K+L  A + K  
Sbjct:   22 YKLVMLGAGGVGKSAMTMQFIS---HRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVSKEEGLSLAREFSCPFFETSAAYRYYIDDVFHALVREIRKKEKELVLAMEKKAK 198
[Close]
BLAST of GTP-binding protein GEM vs. UniProt/SwissProt
Match: sp|O35929|REM1_MOUSE (GTP-binding protein REM 1 OS=Mus musculus OX=10090 GN=Rem1 PE=1 SV=1)

HSP 1 Score: 83.1889 bits (204), Expect = 1.126e-16
Identity = 55/204 (26.96%), Postives = 100/204 (49.02%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDN--ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLS 1132
            + V ++G  GVGKT+L   F   +    +  +      + + T+ +D  + TLV+ D      LD      +  ++  AY+IVYSI D+ SF+  +++   L  +   +   I +V  K+DL R R+VS E+G+  A ++D +FIE S  L H +  L   ++ ++R     LR+  ++        ++++ G     F  RL+
Sbjct:   81 YRVVLLGDPGVGKTSLASLFAEKQDRDPHEQLGG----VYERTLSVDGEDTTLVVMDTWEAEKLDESWCQESCLQAGSAYVIVYSIADRSSFESASELRIQLRRTHQANHVPIILVGNKADLARCREVSVEEGRACAVVFDCKFIETSATLQHNVTELFEGVVRQLR-----LRRQDNAAPETPSPRRRASLGQRARRFLARLT 275
[Close]
BLAST of GTP-binding protein GEM vs. UniProt/SwissProt
Match: sp|P55040|GEM_HUMAN (GTP-binding protein GEM OS=Homo sapiens OX=9606 GN=GEM PE=1 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 6.157e-16
Identity = 63/203 (31.03%), Postives = 97/203 (47.78%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQF-------------LTSETYGFYSNMDAPDKTIRQVTVDL----DDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F             L  +TY     +D    TI  + +D+     +NEW   LHD         +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K K+S P
Sbjct:   74 TYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVDGESATI--ILLDMWENKGENEW---LHD------HCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRKESMP 263
[Close]
BLAST of GTP-binding protein GEM vs. UniProt/SwissProt
Match: sp|Q5R541|GEM_PONAB (GTP-binding protein GEM OS=Pongo abelii OX=9601 GN=GEM PE=2 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 6.645e-16
Identity = 63/203 (31.03%), Postives = 97/203 (47.78%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQF-------------LTSETYGFYSNMDAPDKTIRQVTVDL----DDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            T + V +IG+ GVGK+ L   F             L  +TY     +D    TI  + +D+     +NEW   LHD         +  DAY+IVYSI D+ SF+  +++   L  +  T    I +V  KSDL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R  +    K K+ +     K K+S P
Sbjct:   74 TYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVDGESATI--ILLDMWENKGENEW---LHD------HCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRTCAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDS--KEKNERRLAYQKRKESMP 263
[Close]
BLAST of GTP-binding protein GEM vs. UniProt/SwissProt
Match: sp|P55042|RAD_HUMAN (GTP-binding protein RAD OS=Homo sapiens OX=9606 GN=RRAD PE=1 SV=2)

HSP 1 Score: 81.2629 bits (199), Expect = 7.688e-16
Identity = 53/170 (31.18%), Postives = 85/170 (50.00%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD----LDDNEWTLVLHDLDN------ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
             + V ++G  GVGK+AL   F   E        D P+      T D    +D  E +L+++D+        +        DAY+IVYS+ DK SF+  +++   L  +  T    I +V  KSDL R R+VS ++G+  A ++D +FIE S  L+H +  L   ++ +IR
Sbjct:   91 VYKVLLLGAPGVGKSALARIFGGVE--------DGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 252
[Close]
BLAST of GTP-binding protein GEM vs. UniProt/SwissProt
Match: sp|O88667|RAD_MOUSE (GTP-binding protein RAD OS=Mus musculus OX=10090 GN=Rrad PE=1 SV=1)

HSP 1 Score: 80.8777 bits (198), Expect = 9.656e-16
Identity = 55/170 (32.35%), Postives = 86/170 (50.59%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD----LDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
             + V ++G  GVGK+AL   F   E        D P+      T D    +D  E +L+++D+   D    +        DAY+IVYSI DK SF+  +++   L  +  T    I +V  KSDL R R+VS ++G+  A ++D +FIE S  L+H +  L   ++ +IR
Sbjct:   91 VYKVLLLGAPGVGKSALARIFGGIE--------DGPEAEAAGHTYDRSITVDGEEASLLVYDIWEEDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 252
[Close]
BLAST of GTP-binding protein GEM vs. TrEMBL
Match: A0A1S3JCD3 (GTP-binding protein REM 1 OS=Lingula unguis OX=7574 GN=LOC106171651 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 2.980e-29
Identity = 99/279 (35.48%), Postives = 146/279 (52.33%), Query Frame = 2 
Query:  311 RIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYG-FYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFE-ESPDAYIIVYSIEDKDSFDWCTQVLQNLL-ESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLSKA 1138
            R+RSF  + KG+ N+GDTVK+ S + +   +           YR    D++   +   S +      Q   +     K  + V ++G  GVG+TAL  QFLTSE  G F ++ D  ++  + V+V LD  E  +VL D  N     + E  DA +IVYS+ D+ SF++ T VL  L  E   T AI +V  KSD+ R R+VS ++G+ +A  YD ++ E S VLNH +D LLV  +T+I R K++    K SKT    K  K      +    RR+SK+
Sbjct:  150 RVRSFTLSSKGLQNKGDTVKHTSSMQIGASSCDNCCAAAAEEYR----DRTSSVNSRGSGT------QTSEDSSGHEKIPYKVAILGAMGVGRTALTRQFLTSEYLGAFDTSFDEDEE--KSVSVLLDGEESEMVLMDPMNEQNLHQYEDADAIVIVYSMADRASFEYATDVLFRLRKEDNYTKAIILVGNKSDIVRGREVSLDEGRSIAMTYDCKYTETSAVLNHNVDELLVGTLTQI-RLKEQEHGQKPSKTRCVPKSAKQIITRFWKKNGRRVSKS 415
[Close]
BLAST of GTP-binding protein GEM vs. TrEMBL
Match: A0A1D1V8K9 (Uncharacterized protein OS=Ramazzottius varieornatus OX=947166 GN=RvY_06833-1 PE=4 SV=1)

HSP 1 Score: 126.331 bits (316), Expect = 1.011e-28
Identity = 97/284 (34.15%), Postives = 147/284 (51.76%), Query Frame = 2 
Query:  290 EKESMLYRIRSFKRTHKGVI-NQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTI-RQVTVDLDDNEWTLVLHDLDNISTTFEE------SPDAYIIVYSIEDKDSFDWCTQVLQNL--LESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR-------RHKKKLRKAKDSKTNYSMKHKKS 1090
            +K+  +Y++R+F  T +GV+ N+GD  +  S+ S N P        G  P     N++  +SS   + +   L      E  ++  + + V + G  GVGKTAL  QFLTSE    Y ++   +  + + V+V LD  E  L   D +N S+ ++E      S DA++IVYS+ D+ SF+    +L  L  +E     AI +V  K+DL R R VS E+G  +AS YD +F E S  +NH +D LLV I+T+IR       R  KK R  K ++ N     K+S
Sbjct:  121 DKDPTVYKLRTFDVTSRGVVKNRGDLYRPKSISSNNTPI-------GSIPTEALRNERMSVSSAYSTGAETSLS----GEGSQQGNSRYKVLMSGTTGVGKTALTNQFLTSEYLNAYDSLSTDEDAMEKSVSVLLDGQESELDFMDPENSSSVYDEKSWDPASVDAHVIVYSVADRPSFEKAIDILFELKQMEVTRHHAIILVGNKTDLVRARVVSKEEGIAVASQYDCKFTETSAGVNHNVDELLVGILTQIRLKEKETARRNKKKRPYKYNRVNGRKNEKRS 393
[Close]
BLAST of GTP-binding protein GEM vs. TrEMBL
Match: A0A4E0RHY2 (Rad and Gem GTP binding protein 1 OS=Fasciola hepatica OX=6192 GN=D915_002099 PE=4 SV=1)

HSP 1 Score: 125.946 bits (315), Expect = 7.823e-28
Identity = 102/320 (31.87%), Postives = 151/320 (47.19%), Query Frame = 2 
Query:  305 LYRIRSFKRTHKGVINQGDTV----------------KNCSL-LSLNL-------------PTRSKSFTK---GENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQK-KEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNIS---------------------TTFEESPDA-------------YIIVYSIEDKDSFDWCTQVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLR 1042
            LYR+RSFK T KGVIN GDT                 KNC + L+  L             PT S  FT+     +P + + +D S   +      + +  P N+N ++  E      + ++G   VGKTALC Q +TSE  G      + D   R VTV+LDD  W +VL D       D+++                     +T +  P +             Y++V++++D  SFD+ +++LQ L +  S   I +V  K+DL R R V  EKGKRLA ++  ++ EVST +NH++D LLV II ++    KKLR
Sbjct:  219 LYRVRSFKLTRKGVINLGDTFRTRSVVGLASSHADHWKNCDIHLTQRLSDGEPSTKSAGLGPTESFLFTRLSHSPSPKQGDADDSSRRPTLRPEAGLQINTP-NVNPKEDTENDQPIRIQIVGFPNVGKTALCRQMITSEFLGARMESMSEDTVERYVTVELDDQTWNIVLIDNFGEAGADDLALVSSIRSQEQRSSSSDSNAAQSTLQLLPQSKSTGSTLIKDVLVYLLVFAVDDTRSFDYVSKLLQVLSKVSSDQIIMLVGNKADLVRCRTVPNEKGKRLAHLHGCKYFEVSTAINHLVDELLVGIILQV----KKLR 533
[Close]
BLAST of GTP-binding protein GEM vs. TrEMBL
Match: A0A1S3J8A1 (GTP-binding protein REM 1 OS=Lingula unguis OX=7574 GN=LOC106170940 PE=4 SV=1)

HSP 1 Score: 122.865 bits (307), Expect = 2.216e-27
Identity = 86/250 (34.40%), Postives = 129/250 (51.60%), Query Frame = 2 
Query:  305 LYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESPD----AYIIVYSIEDKDSFDWCTQVLQNLLESLS-TSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKL 1039
             YR+R+F  + KG+ N+GD+ K   LL    PT       GE+      +D+ P+S            P++           F V V+G  GVG+ +L  QF TSE             +   V+V LD  E      ++  +++T EE  D    AYI+VY+I DK SF + +++LQ L ++     AI +V  KSDL R R VS + GK+LASI++ +FIE S VLNH +D LLV  +++I R + ++
Sbjct:  139 FYRVRNFTVSRKGLFNRGDSYKRRVLLPQ--PT----LGTGESSDSVFADDEPPVSPRAS--------PRDSRTSSTAADRVFRVAVLGTPGVGRMSLVRQFTTSEDVAARGTHSGNKTSDLSVSVLLDGRET-----EMQFVTSTLEECRDKDVDAYIVVYAIADKCSFQYVSEILQRLRQTEGEQCAIILVGNKSDLARTRVVSTDAGKKLASIFNCKFIETSAVLNHHVDELLVGTLSQINRREMQV 369
[Close]
BLAST of GTP-binding protein GEM vs. TrEMBL
Match: A0A074ZG64 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_07740 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 4.634e-27
Identity = 74/191 (38.74%), Postives = 114/191 (59.69%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMD-APDKTIRQVTVDLDDNEWTLVLHDLD--------NISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLL-ESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPG 1099
            V V+G   VGKT+LC QF TSE+     N+D   D+  R +TV++++ ++ L L D +        N ++   ES DAY++VY+I+D+ SF     ++  LL +   +SAI + A KSDL R R VS E+GK LA++Y+  F E+ST LNH +D LLV I+  I+  ++++ K +D     +M  K S+ G
Sbjct:  346 VQVLGMGRVGKTSLCLQFQTSESLDV--NLDRTEDEQTRALTVEVNNMKFNLELFDTNLMEDDFQTNAASLIVESADAYVVVYAIDDRSSFLMARSIVSYLLGQCKRSSAILLAANKSDLVRTRAVSVEEGKNLATVYNCPFYEISTSLNHRVDELLVGIVIAIQERRREVDKERDRLEKMAMNTKHSSLG 534
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Cavefish
Match: rrad (RRAD, Ras related glycolysis inhibitor and calcium channel regulator [Source:NCBI gene;Acc:103041283])

HSP 1 Score: 83.5741 bits (205), Expect = 1.343e-17
Identity = 58/168 (34.52%), Postives = 92/168 (54.76%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
            + V ++G++GVGK++L   F   E    +   DA +   R +TVD  + E  ++L+D+   DN   +     +  DAYIIVYS+ DK SF+  +++   L  +  +    I +V  KSDL R R+VS E+G   A ++D +FIE S  L+H +  L   I+ +IR  K
Sbjct:   91 YKVVLLGEHGVGKSSLARIFGGVEDN--HDCEDAGNTYDRSITVD--EEEANILLYDVWEQDNSQWLKDQCMKMGDAYIIVYSVTDKSSFEKASELRIQLRRARQSENIPIILVGNKSDLVRSREVSVEEGSACAVVFDCKFIETSASLHHNVRTLFEGIVRQIRLRK 254
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Cavefish
Match: rrad (RRAD, Ras related glycolysis inhibitor and calcium channel regulator [Source:NCBI gene;Acc:103041283])

HSP 1 Score: 82.8037 bits (203), Expect = 2.610e-17
Identity = 58/168 (34.52%), Postives = 92/168 (54.76%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
            + V ++G++GVGK++L   F   E    +   DA +   R +TVD  + E  ++L+D+   DN   +     +  DAYIIVYS+ DK SF+  +++   L  +  +    I +V  KSDL R R+VS E+G   A ++D +FIE S  L+H +  L   I+ +IR  K
Sbjct:  116 YKVVLLGEHGVGKSSLARIFGGVEDN--HDCEDAGNTYDRSITVD--EEEANILLYDVWEQDNSQWLKDQCMKMGDAYIIVYSVTDKSSFEKASELRIQLRRARQSENIPIILVGNKSDLVRSREVSVEEGSACAVVFDCKFIETSASLHHNVRTLFEGIVRQIRLRK 279
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Cavefish
Match: rem1 (GTP-binding protein REM 1 [Source:NCBI gene;Acc:103041805])

HSP 1 Score: 77.7962 bits (190), Expect = 9.962e-16
Identity = 58/202 (28.71%), Postives = 98/202 (48.51%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESPD------------AYIIVYSIEDKDSFDWCTQVLQNL--LESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMD 1114
            + V ++G +GVGK++L   F   +    + ++   D   R +TVD    E TLV+  +D   T  +E  +            AY+IVYSI D+ SF+  +++   L  +       I +V  KSDL R R+V+ E+G+  A ++D +FIE S  L+H +  L   I+ +IR  +      +  ++ Y  K   +     F+D
Sbjct:   78 YRVVLLGDHGVGKSSLASIFAGIQEKDAHHHI-GEDTYERTLTVD--GEETTLVV--MDTWETEKQEEDEKWVQDYCMQVGNAYVIVYSITDRSSFESASELRIQLRRIRQAENIPIILVGNKSDLVRCREVAVEEGRACAVVFDCKFIETSASLHHNVHELFEGIVRQIRLRRDSKETNERRRSFYKRKESITKKARRFLD 274
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Cavefish
Match: rit1 (Ras like without CAAX 1 [Source:NCBI gene;Acc:103032482])

HSP 1 Score: 75.0998 bits (183), Expect = 2.438e-15
Identity = 54/201 (26.87%), Postives = 98/201 (48.76%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKL-----RKAKDSKTNYS-MK---HKKSTPGN 1102
            + + ++G+ GVGK+A+  QF++   + F  + D   +   +  + +DD    L + D         +   +  + + +II YSI D+ SF       + +     T  + + +V  KSDL  LRQVS E+GK LA  +   F E S    + ID +   ++ +IR+ + ++     RK++ S + +S +K   HKK   G+
Sbjct:   14 YKLVMLGEGGVGKSAIIMQFIS---HRFPEDHDPTIEDAYKTQIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIISYSITDRRSFQEARHFKELIYRVRRTVDTPVVLVGNKSDLAHLRQVSMEEGKELAREFQCPFFETSAAFRYYIDEVFAALVRQIRQKEAEVVRGNERKSRRSHSFWSRLKAPFHKKQQSGH 211
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Cavefish
Match: gem (GTP-binding protein GEM [Source:NCBI gene;Acc:103045397])

HSP 1 Score: 75.485 bits (184), Expect = 4.868e-15
Identity = 54/169 (31.95%), Postives = 84/169 (49.70%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTS--------ETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL--DNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
            F V ++G +GVGKTAL   F  +        E YG         +T+ Q  V +D    T+ L D+       +  +S DA+IIVYSI D+ SF   +++   L +      + I +V  K DL R R+VS  +G+  A ++D +FIE S  + H +  L   I+ ++R
Sbjct:   67 FTVVLLGDDGVGKTALASIFAGAADSMQCDCEQYG--------GETVEQHMV-VDGESATVTLLDMWDSQNGDSCPQSGDAFIIVYSITDRASFQKASELRVQLRQEREPNQTPIILVGNKCDLVRRREVSVNEGRTCAMVFDCKFIETSAAMQHNVWPLFEGIVRQLR 226
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Sea Lamprey
Match: RIT2 (Ras like without CAAX 2 [Source:HGNC Symbol;Acc:HGNC:10017])

HSP 1 Score: 74.3294 bits (181), Expect = 1.090e-15
Identity = 46/166 (27.71%), Postives = 81/166 (48.80%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRR 1024
            + + ++G  GVGK+A+  QF++   + F  + D   +   +  V +DD    L + D         +   +  + + +II YSI D+ SF    Q  Q + +   T    + +V  K+DL  +RQVS E+G+ LA  +  +F E S  L   +D +   ++ +IRR
Sbjct:   21 YKIVMLGPGGVGKSAMTMQFIS---HRFPEDHDPTIEDAYKTQVRIDDETAHLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFQEAAQFKQLIYQVRHTYEVPVVLVGNKTDLGEIRQVSQEEGRSLAREFSCQFFETSAALRQYVDEVFYAVVREIRR 183
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Sea Lamprey
Match: ralba (v-ral simian leukemia viral oncogene homolog Ba (ras related) [Source:ZFIN;Acc:ZDB-GENE-040801-267])

HSP 1 Score: 59.6918 bits (143), Expect = 8.663e-11
Identity = 47/184 (25.54%), Postives = 87/184 (47.28%), Query Frame = 2 
Query:  521 NEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLV----LHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAI--FIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKD 1054
            N+ K +      V ++G  GVGK+AL  QF+  E    Y    A D   ++V +D ++ +  ++      D   I   +  S + ++ V+SI + +SF    +  + +L      ++   +V  KSDLE  RQVS E+ +  A  +   ++E S      +D +   ++  +R  K+K+ + KD
Sbjct:    4 NKAKGQNAALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKA-DSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSICEHESFAATLEFREQILRVKEDDSVPFLLVGNKSDLEERRQVSSEEARARAEQWRVSYVETSAKTRANVDKVFFDLMRDVR--KRKMDEGKD 184
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003884.1 (pep scaffold:Pmarinus_7.0:GL478028:39262:45384:-1 gene:ENSPMAG00000003545.1 transcript:ENSPMAT00000003884.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.151 bits (139), Expect = 3.178e-10
Identity = 46/165 (27.88%), Postives = 77/165 (46.67%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVD--LDDNEWTL---VLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAI--FIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
            V ++G  GVGK+AL  QF+  E   F  ++     TIR+  V+   +D+  TL   VL  L  +   +  +   Y  + S+  + +F   T   + +L      +I   +V  KSDLE  RQVS E+ +  A  +   ++E S      +D +   ++ +IR  K
Sbjct:   17 VIMVGSGGVGKSALTLQFMYDE---FLRHLQPRVYTIREAVVNSSAEDSAVTLNPFVLRSLALLENVYNGNGPVYNCMSSLTRRQAFPAFTTHSEQILRVKEDESIPFLLVGNKSDLEERRQVSVEEARSRADQWGVSYVETSAKTRANVDKVFFDLMREIRTRK 178
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001560.1 (pep scaffold:Pmarinus_7.0:GL476528:157506:173211:1 gene:ENSPMAG00000001407.1 transcript:ENSPMAT00000001560.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.8398 bits (133), Expect = 2.082e-9
Identity = 50/182 (27.47%), Postives = 85/182 (46.70%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFY--SNMDAPDKTI----RQVTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCT------QVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTN 1066
            V ++G  GVGK+AL  QF+  E    Y  +  D+  K +     +V +D+ D   T    D   I   +  S + ++  +SI + +SF   T      Q+L+  ++   +    +V  KSDLE  RQVS E+ +  A  +   ++E S      +D +   ++ +IR      RK +D+K N
Sbjct:   17 VIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILD---TAGQEDYAAIRDNYFRSGEGFLCAFSICEHESFAGTTDLRRSEQILR--VKEDDSIPFLLVGNKSDLEERRQVSIEEARARADQWGVGYVETSAKTRANVDKVFFDLMREIR-----TRKMEDNKDN 188
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Sea Lamprey
Match: rab8a (RAB8A, member RAS oncogene family [Source:ZFIN;Acc:ZDB-GENE-070424-36])

HSP 1 Score: 54.299 bits (129), Expect = 6.137e-9
Identity = 37/145 (25.52%), Postives = 70/145 (48.28%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVST 967
            F + +IG +GVGKT +  +F        + +     + + QV + +D  +  L + D         I+T +       ++VY I ++ SF+     ++N+ E  S     +V  K D+   RQV+ ++G++LA  Y+ +F+E S 
Sbjct:    9 FKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGGSRPVCQVCIRIDLKKIKLQIWDTAGQERFRTITTAYYRGAMGSMLVYDITNEKSFENIKNWIRNIEEHASADVQKMVGNKCDMNDRRQVTKDRGEKLAEDYNIQFMETSA 153
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Yeast
Match: RSR1 (GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases [Source:SGD;Acc:S000003384])

HSP 1 Score: 58.151 bits (139), Expect = 3.657e-10
Identity = 49/194 (25.26%), Postives = 95/194 (48.97%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIR---QVTVDLDDNEWTLVLHDLDNIS--TTFEE----SPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAI--FIVATKSDLERLRQVSCEKGKRLASIYD-AEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            + + V+G  GVGK+ L  QF+     G Y  +D  D TI    + T+++D+  + L + D   I+  T   E    S   +++VYS+ D+ S +   ++ + +L    +  +   ++  K+DL   R +S E+G  ++S +    F E S +L   +D + V ++ +I R++ +    KD++       K  +P
Sbjct:    4 YKLVVLGAGGVGKSCLTVQFVQ----GVY--LDTYDPTIEDSYRKTIEIDNKVFDLEILDTAGIAQFTAMRELYIKSGMGFLLVYSVTDRQSLEELMELREQVLRIKDSDRVPMVLIGNKADLINERVISVEEGIEVSSKWGRVPFYETSALLRSNVDEVFVDLVRQIIRNEMESVAVKDARNQSQQFSKIESP 191
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Yeast
Match: YPT6 (Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6 [Source:SGD;Acc:S000004252])

HSP 1 Score: 49.2914 bits (116), Expect = 2.112e-7
Identity = 50/194 (25.77%), Postives = 84/194 (43.30%), Query Frame = 2 
Query:  545 TTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAIF--IVATKSDLERLRQVSCEKGKRLASIYDAE-FIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPG 1099
            T + +  +G+ GVGKT+L  +F+       Y      D      T+ LDD    L L D        ++  ++       IIVY I  + SF++  + ++++        +   IV  KSDL   RQ+S E+G++ A +  A+ F+E ST   + +  L  +I   +   +       DS+   S    K  PG
Sbjct:    9 TKYKIVFLGEQGVGKTSLITRFMYDTFDDHYQATIGID--FLSKTMYLDDKTIRLQLWDTAGQERFRSLIPSYIRDSRVAIIVYDITKRKSFEYIDKWIEDVKNERGDENVILCIVGNKSDLSDERQISTEEGEKKAKLLGAKIFMETSTKAGYNVKALFKKIAKSLPEFQNSESTPLDSENANSANQNK--PG 198
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Yeast
Match: YPT1 (Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by type II protein geranylgeranyltransferase (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the unfolded protein response (UPR) by promoting the decay of HAC1 RNA; localizes to the early Golgi, the transitional Golgi and ER membranes, pre-autophagosomal structures, and cytoplasmic vesicles [Source:SGD;Acc:S000001856])

HSP 1 Score: 46.9802 bits (110), Expect = 1.395e-6
Identity = 44/166 (26.51%), Postives = 80/166 (48.19%), Query Frame = 2 
Query:  551 FDVFVIGKNGVGKTALCEQFLTSETY-GFYSNMDAPDKTIRQVTVDLDDNEWTLVLHD------LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAI--FIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
            F + +IG +GVGK+ L  +F + +TY   Y +    D  I+  TV+LD     L + D         I++++       IIVY + D++SF+     LQ  ++  +TS +   +V  K DL+  R V  +  K  A      F+E S + +  +++  + +  +I+
Sbjct:    9 FKLLLIGNSGVGKSCLLLRF-SDDTYTNDYISTIGVDFKIK--TVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMWLQE-IDRYATSTVLKLLVGNKCDLKDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQIK 170
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Yeast
Match: RAS1 (GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication [Source:SGD;Acc:S000005627])

HSP 1 Score: 46.595 bits (109), Expect = 2.882e-6
Identity = 44/160 (27.50%), Postives = 72/160 (45.00%), Query Frame = 2 
Query:  587 KTALCEQFLTSETYGFYSNMDAPDKTI-----RQVTVDLDDNEWTLVLHDLDN--------ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR 1021
            K+AL  QF+ S    ++  +D  D TI     +QV +D    +   +L  LD         +   +  + + +++VYS+  ++SFD      Q +     +    + +V  K DLE  RQVS E G RLA   +A F+E S      +D     +I  +R
Sbjct:   23 KSALTIQFIQS----YF--VDEYDPTIEDSYRKQVVID----DKVSILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVR 172
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Nematostella
Match: EDO46259 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQA3])

HSP 1 Score: 69.707 bits (169), Expect = 4.265e-14
Identity = 57/178 (32.02%), Postives = 97/178 (54.49%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFY-SNMDAPDKTIRQ-----VTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFD---WCTQVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNH-MIDNLLVQIITKIRRHK-KKLRKAKDS 1057
            V V+GK+GVGK+AL  +FLT    G Y   +++  + I Q     V++D+ D        ++ +    +    D Y+++YSI D+ SFD   W  + +++   + S S + IVATK DL+ LR+V  E+G   ++  D  F EVS    +  +  LL +++ +I R++ +K  + KDS
Sbjct:   11 VVVLGKDGVGKSALTVRFLTRRFIGEYDQTLESTHRHILQIDNEDVSLDISDTA-----GEVRDKLRRWTRRGDLYLVLYSIVDRSSFDEARWIARYVKDHRNTDSMSMV-IVATKKDLDHLRRVDIEEGLGFSNELDCTFYEVSISEGYNEVQELLHELLKRITRNRGEKGTEKKDS 182
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Nematostella
Match: EDO49163 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH58])

HSP 1 Score: 63.5438 bits (153), Expect = 1.327e-11
Identity = 57/203 (28.08%), Postives = 100/203 (49.26%), Query Frame = 2 
Query:  563 VIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQ--------VTVDLDDNEWTLVLHDLDNIST--TFEESPDAYIIVYSIEDKDSFDWCTQVLQNLL--ESLSTSA--IFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVS-----TVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMD 1114
            V+GK+GVGK+AL  +FLT    G Y N    + T R         +++D+ D       + ++ +ST  TF E    + IVYS+ D+ SFD    +++ +   ++  T+A  + IVA K DL  LRQV   +G+ LA   +  F  VS     + +  +++  L Q + + R    ++ + K+     +   ++ + G+  MD
Sbjct:   21 VLGKDGVGKSALTVRFLTRRFIGEYDN--TLEATYRHHLIVDGQFISLDIMDTAGK---NSVEKMSTCLTFAE---LFFIVYSVTDRTSFDEARLLVKYIQNDKTAQTAAPTMIIVANKCDLTHLRQVEEIEGQMLARSMEGLFFPVSVSEGYSEIQEILEESLRQCMNRERNKGSRMSRVKEGLRGTAKSLRRKSTGDAMMD 215
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Nematostella
Match: EDO47719 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLN1])

HSP 1 Score: 60.4622 bits (145), Expect = 5.259e-11
Identity = 48/148 (32.43%), Postives = 73/148 (49.32%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESP----------DAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSA--IFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVS 964
            V +IG++GVGK+AL  +FLT    G Y   D  + T RQ      D E    +  ++   T  E SP          + ++++YSI  + SFD  +++   + E  S+ A  + +V TK DLE  R V   +G  LA   +A F E+S
Sbjct:    5 VVIIGEDGVGKSALTVRFLTKRFIGEYD--DTLESTYRQ------DAEVAGEVVAIELTDTAGENSPAKLERCLEIGEVFVVLYSITSRHSFDEASRIGTYIKERKSSDAMTLTLVGTKKDLEHFRIVQETEGSDLAQELEATFFEIS 144
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Nematostella
Match: EDO49165 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH60])

HSP 1 Score: 58.5362 bits (140), Expect = 2.062e-10
Identity = 44/144 (30.56%), Postives = 75/144 (52.08%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTL-VLHDLDNIST----TFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST---SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVS 964
            V V+G++GVGK+AL  + LT    G Y   D+  ++  +    LD     L VL     + T       ES D ++I+YS+ D+ SF+   ++++ +  + +    S++ +V TK+DLE LR+V  + G   A   +  F E+S
Sbjct:    3 VVVLGQDGVGKSALTVRLLTKRFIGEY---DSTLESAYRHHFMLDPEIIPLDVLDTAGRVGTPDREARGESSDIFVILYSVTDRKSFNEAERIVKKIRGARTVTDESSVLLVGTKTDLEHLREVKTKDGWHTAKHVNCRFYEIS 143
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Nematostella
Match: EDO45827 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRV2])

HSP 1 Score: 57.3806 bits (137), Expect = 8.376e-10
Identity = 43/164 (26.22%), Postives = 77/164 (46.95%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLV----LHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAI--FIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
            V ++G  GVGK+AL  QF+  E    Y    A D   ++  +D ++ +  ++      D   I   +  S + ++ V+SI + +SF   T+  + +L       I   +V  KSDL   RQV+ E+G+  A  +   ++E S      +D +   ++ +IR  K
Sbjct:   14 VIMVGSGGVGKSALTLQFMYEEFVEDYEPTKA-DSYRKKAILDGEECQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEPESFAATTEFREQILRVKGDDKIPFLLVGNKSDLTDKRQVTSEEGQSKADEWGVPYVETSAKTRSNVDKVFFDLMREIRSRK 176
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Medaka
Match: rrad (RRAD, Ras related glycolysis inhibitor and calcium channel regulator [Source:NCBI gene;Acc:101173131])

HSP 1 Score: 82.8037 bits (203), Expect = 2.402e-17
Identity = 56/169 (33.14%), Postives = 92/169 (54.44%), Query Frame = 2 
Query:  548 TFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDL---DN---ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS--AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHK 1030
             + V ++G++GVGK++L   F   E  G   + D    T  +  V +D+ E +++L+D+   DN   +        DAYIIVYS+ DK SF+  +++   L  +  +    I +V  KSDL R R+VS ++G   A ++D +FIE S  L+H + +L   I+ +IR  K
Sbjct:   91 VYKVVLLGEHGVGKSSLARVFGGVEDVGH--DYDEAGNTYDRSLV-VDEEEASILLYDIWEQDNSQWLKDQCMRMGDAYIIVYSVTDKSSFEKASELRIQLRRARQSENIPIILVGNKSDLVRSREVSVDEGSACAVVFDCKFIETSASLHHNVQDLFEGIVRQIRLRK 256
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Medaka
Match: zgc:171704 (ras-like protein family member 11B [Source:NCBI gene;Acc:101164589])

HSP 1 Score: 68.1662 bits (165), Expect = 6.181e-13
Identity = 55/180 (30.56%), Postives = 91/180 (50.56%), Query Frame = 2 
Query:  521 NEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQV-TVDLDDNEW-TLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESL--STSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKA 1048
            N+Q+ E+    ++ ++G + VGKTAL  +FLT    G Y +M++    + ++   ++  N W + V      +S    +  D  I+VY I D+ SFD   Q LQ +  S   ++  + IVA K DL+  R+VS E+G+ LA      F EVS    +    L+   +  + R  + LRK+
Sbjct:   15 NQQRMEV----NILLMGAHNVGKTALTVRFLTRRFIGEYGDMESVYSRMERIHGQEICINIWDSQVGEKSCWVSEKQLQWADGMILVYDICDRGSFDAVRQQLQLVRRSRKPASCPVVIVANKRDLQHHRRVSGEEGRLLALTQGCCFFEVSAAETYHSVLLVFHRLVDLVRETRALRKS 190
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Medaka
Match: ralba (ras-related protein Ral-B [Source:NCBI gene;Acc:101157118])

HSP 1 Score: 67.3958 bits (163), Expect = 1.066e-12
Identity = 50/184 (27.17%), Postives = 92/184 (50.00%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEW----TLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS---AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKK 1087
            V ++G  GVGK+AL  QF+  E    Y    A D   ++V +D D+ +     T    D   I   +  S + +++V+SI +++SF    +  + +L   +      + +V  KSDLE  R VS E+ +R A  + A+++E S      +D +   ++ ++R  K     +K+++TN + K+ K
Sbjct:   17 VIMVGSGGVGKSALTLQFMYDEFVEDYEPTKA-DSYRKKVVLDGDEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEQESFTATDEFREQILRVKADEDKIPLLLVGNKSDLEERRHVSVEEARRKAEEWGAQYVETSAKTRANVDKVFFDLMREVRGKK----MSKNNQTNGNGKNNK 195
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Medaka
Match: ralba (ras-related protein Ral-B [Source:NCBI gene;Acc:101157118])

HSP 1 Score: 67.3958 bits (163), Expect = 1.066e-12
Identity = 50/184 (27.17%), Postives = 92/184 (50.00%), Query Frame = 2 
Query:  557 VFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEW----TLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTS---AIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKK 1087
            V ++G  GVGK+AL  QF+  E    Y    A D   ++V +D D+ +     T    D   I   +  S + +++V+SI +++SF    +  + +L   +      + +V  KSDLE  R VS E+ +R A  + A+++E S      +D +   ++ ++R  K     +K+++TN + K+ K
Sbjct:   17 VIMVGSGGVGKSALTLQFMYDEFVEDYEPTKA-DSYRKKVVLDGDEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEQESFTATDEFREQILRVKADEDKIPLLLVGNKSDLEERRHVSVEEARRKAEEWGAQYVETSAKTRANVDKVFFDLMREVRGKK----MSKNNQTNGNGKNNK 195
[Close]
BLAST of GTP-binding protein GEM vs. Ensembl Medaka
Match: rasl11b (RAS like family 11 member B [Source:NCBI gene;Acc:101155914])

HSP 1 Score: 67.781 bits (164), Expect = 1.533e-12
Identity = 45/160 (28.12%), Postives = 83/160 (51.88%), Query Frame = 2 
Query:  524 EQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFY----SNMDAPDKTI--RQVTVDLDDNEWTLVLHD----LDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST--SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVST 967
             + + +     + V+G +GVGKTAL  +FLT    G Y     N+ + +  +   QVT+ + D     + ++     D+++ + + + DA ++VYS+ D+ SFD  +Q+ Q ++ +       + ++A K+DL  LR+V  ++G  LA      F EVS 
Sbjct:   16 PENQPLSRVIKIAVVGGSGVGKTALVVRFLTRRFIGDYERNAGNLYSREVQVDGEQVTIQVQDTPGGEMTNNGVKLPDHVTCSIQWA-DAVVLVYSVTDRRSFDLISQLHQLVVRAGGAIVPPVILLANKADLLHLRRVDSQQGPLLAGALGCSFYEVSA 174
[Close]
BLAST of GTP-binding protein GEM vs. Planmine SMEST
Match: SMESG000018613.1 (SMESG000018613.1)

HSP 1 Score: 695.271 bits (1793), Expect = 0.000e+0
Identity = 348/349 (99.71%), Postives = 349/349 (100.00%), Query Frame = 2 
Query:   95 MDDFDQYCSWARKPNDFIEQYQARALGSYEVLDMAEDGKELYESDNQIYGETNNLLSNEDNERISEKESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLSKAF 1141
            MDDFDQYCSWARKPNDFIEQYQARALGSYEVLDMAEDGKELYESDNQIYGETNNLLSNEDNERISEKESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKSPISSPEESHSIDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQ+LQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLSKAF
Sbjct:    1 MDDFDQYCSWARKPNDFIEQYQARALGSYEVLDMAEDGKELYESDNQIYGETNNLLSNEDNERISEKESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKSPISSPEESHSIDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQILQNLLESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLSKAF 349
[Close]
BLAST of GTP-binding protein GEM vs. Planmine SMEST
Match: SMESG000032890.1 (SMESG000032890.1)

HSP 1 Score: 167.162 bits (422), Expect = 1.798e-47
Identity = 112/298 (37.58%), Postives = 167/298 (56.04%), Query Frame = 2 
Query:  305 LYRIRSFKRTHKGVINQGDTVKNCSLLSLN----LPT----RSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQK-------KEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKT--IRQVTVDLDDNEWTLVL------HDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNL-LESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRR 1126
            LYR+RS K+T KGVI++GD V+N S  SL      P     +S + +K  +P  +    K      +++   ++   ++ ++ +       K   T+F++ V+G   VGK+++CEQFLTSE  G   N   P+K    R VT+DLD+ EW L         D D  +     + D Y+IVY+I++ DSF++   +L  +  E    SA+F+VA KSDLER R++S E GK LA  YD EF+E+ST LNHM+D+L+V+II KI   K+K +K K  +     K K  T  N   +FFR+
Sbjct:   98 LYRVRSLKKTPKGVISKGDLVRNHSNQSLEKEFVYPCTEHHQSLNSSKVNSPKSFETKKKKEALRLKQTTMPNVSFERSRDDSQIHWHANLKSRSTSFNIQVVGAPLVGKSSMCEQFLTSEYLG---NSSIPEKANESRTVTIDLDNREWNLTFLDTVRDEDDDPNNIQIYHNADGYMIVYAIDEYDSFEYAKIILNYIRCEIPPDSALFLVANKSDLERGREISSEDGKHLAKQYDCEFLEISTALNHMVDDLIVKIIHKICHQKEKYKKDKREEVTAEKKPKSHT--NSITNFFRK 390
[Close]
BLAST of GTP-binding protein GEM vs. Planmine SMEST
Match: SMESG000057130.1 (SMESG000057130.1)

HSP 1 Score: 136.732 bits (343), Expect = 3.612e-36
Identity = 98/290 (33.79%), Postives = 158/290 (54.48%), Query Frame = 2 
Query:  236 IYGETNNLLSNEDNERISEKESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPYRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDNISTTFE--ESPDAYIIVYSIEDKDSFDWCTQVLQNL-LESLSTSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTP 1096
            I  E + LLSN      S +E+ + R+RSF+RT KG++   DT++  S   L+    +++ +     + + N+ KS             L  Q +    + I+ T  +F  G++GVGKT+LC+Q L  E     ++        + + V +D+ E  L L D +N     E  E  DAY+++Y+I+D  SF+ C +++ NL L +++   + +VA KSDL R R VS +KGKRLA IY+ +F E+ST LNH +D LLV ++T++R   K+  K    K N+  K  ++TP
Sbjct:   94 IEPEKDQLLSNVS----SGEENKIVRLRSFRRTTKGIVCNKDTIEIESEKELSRSFDTRNLSNNNEHFHFKNDRKSE------------LENQKLPNDGEIIRYTVTLF--GQDGVGKTSLCQQLLLPEYLVSQADEIKSHNEAQMIRVLIDNQESILRLIDSENCENFIEPKEVSDAYLVIYAIDDNSSFETCRKLIANLVLTNVNPPLVILVANKSDLVRSRVVSTDKGKRLAGIYNLKFKEISTSLNHCVDELLVLLVTEMRNASKRTEK---HKVNFISKGFQNTP 362
[Close]
BLAST of GTP-binding protein GEM vs. Planmine SMEST
Match: SMESG000060724.1 (SMESG000060724.1)

HSP 1 Score: 132.494 bits (332), Expect = 1.947e-34
Identity = 106/311 (34.08%), Postives = 158/311 (50.80%), Query Frame = 2 
Query:  266 NEDNERISE-KESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLNL--PTRSKSFTKGENP------YRYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQ-VTVDLDDNEWTLVLHDLDN--------ISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESLST-SAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIR-----RHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRR 1126
            NE+ + +S+  E  +YR+RSFKRT KG+++Q DT+K  S+ SL    P     + K E+       YR                    L      EQK  I    +V +IG N VGKT +  QF+TSE       MD+ ++   + V+V  DD EW + LHD +N        ++       + Y++VY+I++  SF +   +L +L+E  S  S I +V  K DLER R+VS E GK+LA I+   F EVST +NH ID LL+Q + KIR     + K+ L+ +    TN  +   +++ G     FF+R
Sbjct:  138 NENQKDLSDDGEIQMYRMRSFKRTSKGIVSQADTIKARSINSLEKFDPLEDSKWDKNESEEFHFPCYR--------------------LGISCGPEQK--IVNRLEVQIIGSNFVGKTTMASQFMTSE--HICGRMDSVNEDADKFVSVFFDDQEWNIWLHDTENKKDADSNEVTVELLSGMNGYMVVYAIDNMSSFIYTKHILTDLVEKASRDSVIALVGNKIDLERCREVSRESGKQLAKIHRCLFYEVSTAINHKIDELLIQTLMKIRNNLKAKEKRFLKYSNLQNTNRRVSSFRNS-GKKIRSFFKR 423
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BLAST of GTP-binding protein GEM vs. Planmine SMEST
Match: SMESG000019070.1 (SMESG000019070.1)

HSP 1 Score: 123.25 bits (308), Expect = 2.128e-31
Identity = 83/258 (32.17%), Postives = 135/258 (52.33%), Query Frame = 2 
Query:  314 IRSFKRTHKGVINQGDTVKNCSLLSLNLPTRSKSFTKGENPY-RYNNNDKXXXXXXXXXXXXDLLVPQNINEQKKEIKTTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDDNEWTLVLHDLDN--ISTTFE------ESPDAYIIVYSIEDKDSFDWCTQVLQNLLESL-STSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNLLVQIITKIRRHKKKLRKAKDS 1057
            +RSFK T KG+IN+GD           L +RS    K EN + +YN N                      +++   I +   + ++G NGVGKT L  QF+TSE       M   ++T +  ++ +D  EW ++LHD  N  I  T E      +  +AYI++++I+D  SF++  QVL+++ + + +T A ++V  K+DLER R+V  +  K L+ ++   F E+ST LNH +D LL +II  I + + K+   + S
Sbjct:  116 VRSFKVTEKGMINEGDL----------LISRSTGNIKSENIHVQYNGNQ---------------------SDKYSNIDSPLKIQILGANGVGKTTLASQFMTSEQICCRM-MSVNEETEKLFSIRIDGKEWNILLHDTCNMNIDATNEVRVELLDKMNAYIVLFAIDDLASFEYSKQVLKDIFKKVDTTRAAYLVGNKADLERSREVKSKICKELSKVHRCHFYEISTALNHKVDELLCKIIMDILKSQSKVESPRKS 341
The following BLAST results are available for this feature:
BLAST of GTP-binding protein GEM vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
GEM1.282e-1631.03GTP binding protein overexpressed in skeletal musc... [more]
GEM1.282e-1631.03GTP binding protein overexpressed in skeletal musc... [more]
RRAD1.601e-1631.18RRAD, Ras related glycolysis inhibitor and calcium... [more]
RRAD1.601e-1631.18RRAD, Ras related glycolysis inhibitor and calcium... [more]
RIT11.707e-1428.50Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Y52B11A.45.256e-1024.40pep chromosome:WBcel235:I:10979802:11004283:-1 gen... [more]
Y52B11A.45.256e-1024.40pep chromosome:WBcel235:I:10979607:11004283:-1 gen... [more]
ral-11.642e-926.67RAL (Ras-related GTPase) homolog [Source:UniProtK... [more]
ral-13.527e-926.67RAL (Ras-related GTPase) homolog [Source:UniProtK... [more]
rab-84.458e-927.44RAB family; Rab8 [Source:UniProtKB/TrEMBL;Acc:G5E... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rgk16.002e-2629.25gene:FBgn0264753 transcript:FBtr0334282[more]
Rgk24.825e-2531.52gene:FBgn0085419 transcript:FBtr0112633[more]
Rgk29.150e-2530.91gene:FBgn0085419 transcript:FBtr0340386[more]
Rgk11.516e-2429.59gene:FBgn0264753 transcript:FBtr0334283[more]
Rgk11.997e-2428.39gene:FBgn0264753 transcript:FBtr0334284[more]
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BLAST of GTP-binding protein GEM vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rit15.030e-1727.47Ras-like without CAAX 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
rrad4.882e-1632.54Ras-related associated with diabetes [Source:ZFIN;... [more]
rrad4.882e-1632.54Ras-related associated with diabetes [Source:ZFIN;... [more]
rem26.426e-1529.89RAS (RAD and GEM)-like GTP binding 2 [Source:ZFIN;... [more]
rem26.754e-1529.89RAS (RAD and GEM)-like GTP binding 2 [Source:ZFIN;... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rem18.664e-1728.46RAS (RAD and GEM)-like GTP-binding 1 [Source:NCBI ... [more]
mark42.636e-1631.82MAP/microtubule affinity-regulating kinase 4 [Sour... [more]
plekhf23.853e-1631.44pleckstrin homology and FYVE domain containing 2 [... [more]
ENSXETT00000051917.19.510e-1431.55RERG/RAS-like [Source:NCBI gene;Acc:100491594][more]
LRP101.218e-1227.59RAS (RAD and GEM)-like GTP binding 2 [Source:NCBI ... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rem11.610e-1726.96rad and gem related GTP binding protein 1 [Source:... [more]
Rrad1.026e-1632.35Ras-related associated with diabetes [Source:MGI S... [more]
Gem2.410e-1630.54GTP binding protein (gene overexpressed in skeleta... [more]
Gem2.410e-1630.54GTP binding protein (gene overexpressed in skeleta... [more]
Rit19.498e-1527.22Ras-like without CAAX 1 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of GTP-binding protein GEM vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O35929|REM1_MOUSE1.126e-1626.96GTP-binding protein REM 1 OS=Mus musculus OX=10090... [more]
sp|P55040|GEM_HUMAN6.157e-1631.03GTP-binding protein GEM OS=Homo sapiens OX=9606 GN... [more]
sp|Q5R541|GEM_PONAB6.645e-1631.03GTP-binding protein GEM OS=Pongo abelii OX=9601 GN... [more]
sp|P55042|RAD_HUMAN7.688e-1631.18GTP-binding protein RAD OS=Homo sapiens OX=9606 GN... [more]
sp|O88667|RAD_MOUSE9.656e-1632.35GTP-binding protein RAD OS=Mus musculus OX=10090 G... [more]
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BLAST of GTP-binding protein GEM vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3JCD32.980e-2935.48GTP-binding protein REM 1 OS=Lingula unguis OX=757... [more]
A0A1D1V8K91.011e-2834.15Uncharacterized protein OS=Ramazzottius varieornat... [more]
A0A4E0RHY27.823e-2831.88Rad and Gem GTP binding protein 1 OS=Fasciola hepa... [more]
A0A1S3J8A12.216e-2734.40GTP-binding protein REM 1 OS=Lingula unguis OX=757... [more]
A0A074ZG644.634e-2738.74Uncharacterized protein OS=Opisthorchis viverrini ... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rrad1.343e-1734.52RRAD, Ras related glycolysis inhibitor and calcium... [more]
rrad2.610e-1734.52RRAD, Ras related glycolysis inhibitor and calcium... [more]
rem19.962e-1628.71GTP-binding protein REM 1 [Source:NCBI gene;Acc:10... [more]
rit12.438e-1526.87Ras like without CAAX 1 [Source:NCBI gene;Acc:1030... [more]
gem4.868e-1531.95GTP-binding protein GEM [Source:NCBI gene;Acc:1030... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RIT21.090e-1527.71Ras like without CAAX 2 [Source:HGNC Symbol;Acc:HG... [more]
ralba8.663e-1125.54v-ral simian leukemia viral oncogene homolog Ba (r... [more]
ENSPMAT00000003884.13.178e-1027.88pep scaffold:Pmarinus_7.0:GL478028:39262:45384:-1 ... [more]
ENSPMAT00000001560.12.082e-927.47pep scaffold:Pmarinus_7.0:GL476528:157506:173211:1... [more]
rab8a6.137e-925.52RAB8A, member RAS oncogene family [Source:ZFIN;Acc... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
RSR13.657e-1025.26GTP-binding protein of the Ras superfamily; requir... [more]
YPT62.112e-725.77Rab family GTPase; required for endosome-to-Golgii... [more]
YPT11.395e-626.51Rab family GTPase; involved in the ER-to-Golgi ste... [more]
RAS12.882e-627.50GTPase involved in G-protein signaling in adenylat... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO462594.265e-1432.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO491631.327e-1128.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO477195.259e-1132.43Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO491652.062e-1030.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458278.376e-1026.22Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of GTP-binding protein GEM vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rrad2.402e-1733.14RRAD, Ras related glycolysis inhibitor and calcium... [more]
zgc:1717046.181e-1330.56ras-like protein family member 11B [Source:NCBI ge... [more]
ralba1.066e-1227.17ras-related protein Ral-B [Source:NCBI gene;Acc:10... [more]
ralba1.066e-1227.17ras-related protein Ral-B [Source:NCBI gene;Acc:10... [more]
rasl11b1.533e-1228.13RAS like family 11 member B [Source:NCBI gene;Acc:... [more]
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BLAST of GTP-binding protein GEM vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000018613.10.000e+099.71SMESG000018613.1[more]
SMESG000032890.11.798e-4737.58SMESG000032890.1[more]
SMESG000057130.13.612e-3633.79SMESG000057130.1[more]
SMESG000060724.11.947e-3434.08SMESG000060724.1[more]
SMESG000019070.12.128e-3132.17SMESG000019070.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003820 ID=SMED30003820|Name=GTP-binding protein GEM|organism=Schmidtea mediterranea sexual|type=transcript|length=1188bp
CACAACTATAAATTAGGAAAGAGCACTTGTAGATTTTAAGCAATAACTTC
TTTGAAATTTTGTTATTGATTTGTTGTTATAATTTCAATAAAATATGGAT
GATTTTGATCAGTACTGCAGTTGGGCAAGGAAACCAAATGATTTTATTGA
ACAATATCAAGCTAGGGCTTTGGGATCATACGAGGTATTGGATATGGCAG
AGGACGGAAAGGAGTTATATGAATCAGACAATCAGATCTATGGCGAAACT
AATAATTTATTATCCAATGAAGACAATGAAAGAATTTCAGAAAAAGAAAG
CATGCTTTATCGAATAAGAAGCTTCAAAAGAACCCATAAAGGAGTAATAA
ATCAGGGAGATACTGTCAAAAACTGCAGTCTTCTGTCATTAAATCTTCCA
ACTAGGAGTAAAAGTTTCACGAAAGGAGAAAACCCTTACAGATATAATAA
TAATGATAAATCCCCAATAAGTAGTCCTGAAGAAAGCCATTCAATTGATT
TGCTAGTTCCACAAAATATAAATGAGCAAAAAAAAGAAATAAAAACAACA
TTTGATGTTTTTGTAATTGGAAAGAATGGGGTTGGTAAAACTGCTTTATG
TGAACAGTTTTTGACTTCAGAAACATACGGATTTTACTCCAATATGGATG
CACCTGACAAAACTATTCGTCAAGTTACTGTTGATTTAGACGATAATGAA
TGGACTTTAGTACTTCATGATTTGGACAACATTTCAACCACGTTTGAGGA
ATCTCCTGATGCGTATATTATTGTATATTCAATTGAAGATAAAGACAGTT
TTGATTGGTGTACCCAAGTTCTTCAAAATCTGCTCGAATCACTGTCAACT
TCCGCAATATTTATTGTAGCTACAAAGTCTGATTTAGAAAGATTGCGGCA
AGTTTCTTGTGAAAAAGGAAAAAGACTTGCTAGTATCTATGACGCTGAAT
TCATCGAGGTATCTACAGTTTTAAATCACATGATCGACAACTTGTTAGTG
CAAATTATTACCAAAATTCGACGGCACAAAAAGAAGCTAAGAAAGGCCAA
AGATTCCAAAACCAACTATTCAATGAAACATAAAAAATCCACACCCGGAA
ACTTATTCATGGACTTCTTCCGAAGACTTTCAAAAGCTTTCTAAATTGAT
AATGGAAACAAATACAAAATATTACATTTGTCAGATCG
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protein sequence of SMED30003820-orf-1

>SMED30003820-orf-1 ID=SMED30003820-orf-1|Name=SMED30003820-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=350bp
MDDFDQYCSWARKPNDFIEQYQARALGSYEVLDMAEDGKELYESDNQIYG
ETNNLLSNEDNERISEKESMLYRIRSFKRTHKGVINQGDTVKNCSLLSLN
LPTRSKSFTKGENPYRYNNNDKSPISSPEESHSIDLLVPQNINEQKKEIK
TTFDVFVIGKNGVGKTALCEQFLTSETYGFYSNMDAPDKTIRQVTVDLDD
NEWTLVLHDLDNISTTFEESPDAYIIVYSIEDKDSFDWCTQVLQNLLESL
STSAIFIVATKSDLERLRQVSCEKGKRLASIYDAEFIEVSTVLNHMIDNL
LVQIITKIRRHKKKLRKAKDSKTNYSMKHKKSTPGNLFMDFFRRLSKAF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003924GTPase activity
GO:0005525GTP binding
GO:0000166nucleotide binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
PLANA:0000419prepharyngeal region
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR020849Small_GTPase_Ras-type
IPR001806Small_GTPase
IPR027417P-loop_NTPase
Vocabulary: biological process
TermDefinition
GO:0007264small GTPase mediated signal transduction
GO:0007165signal transduction
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePRINTSPR00449RASTRNSFRMNGcoord: 153..174
score: 37.54
coord: 251..264
score: 31.12
coord: 286..308
score: 19.88
NoneNo IPR availableSMARTSM00175rab_sub_5coord: 153..311
e-value: 5.5E-7
score: -22.5
NoneNo IPR availableSMARTSM00173ras_sub_4coord: 150..311
e-value: 6.5E-9
score: 13.0
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 150..315
e-value: 1.2E-32
score: 114.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 110..131
NoneNo IPR availablePANTHERPTHR45775FAMILY NOT NAMEDcoord: 68..330
IPR001806Small GTPasePFAMPF00071Rascoord: 155..309
e-value: 2.9E-20
score: 72.5
IPR020849Small GTPase superfamily, Ras-typePROSITEPS51421RAScoord: 144..339
score: 12.563
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILYSSF52540P-loop containing nucleoside triphosphate hydrolasescoord: 150..320