Transcription factor 7-like 1

Overview
NameTranscription factor 7-like 1
Smed IDSMED30003783
Length (bp)1424
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Transcription factor 7-like 1 (SMED30003783) t-SNE clustered cells

Violin plots show distribution of expression levels for Transcription factor 7-like 1 (SMED30003783) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30003783

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30003783h1SMcG0013594 SmedASXL_004747SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
head regionSMED30003783h1SMcG0013594 SmedASXL_000179SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
head regionSMED30003783h1SMcG0013594 SmedASXL_019557SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
X2 cellSMED30003783h1SMcG0013594 SmedASXL_019557SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
head regionSMED30003783h1SMcG0013594 dd_Smed_v6_31950_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30003783h1SMcG0013594 dd_Smed_v6_34144_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30003783h1SMcG0013594 dd_Smed_v6_58683_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
neuronSMED30003783h1SMcG0013594 Contig55186uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30003783h1SMcG0013594 Contig55186newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
lateral branchSMED30003783h1SMcG0013594 Contig55186uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
lateral branchSMED30003783h1SMcG0013594 Contig55186newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 162.925 bits (411), Expect = 8.856e-48
Identity = 83/127 (65.35%), Postives = 96/127 (75.59%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQ------GLSMCN 983
            SG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++       G+  C 
Sbjct:   18 SGKQELQPFDRN-LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTDGIPACT 143
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 164.081 bits (414), Expect = 1.926e-47
Identity = 81/114 (71.05%), Postives = 93/114 (81.58%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:   29 SGKQELQPFDRN-LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 141
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 164.466 bits (415), Expect = 8.719e-47
Identity = 85/130 (65.38%), Postives = 100/130 (76.92%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIK--RQKKRQGLSMCNTSKIIKD 1004
            SG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +  R+K ++  +  N  + +KD
Sbjct:  125 SGKQELQPFDRN-LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTETNWPRELKD 253
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 163.31 bits (412), Expect = 2.237e-46
Identity = 81/114 (71.05%), Postives = 93/114 (81.58%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  125 SGKQELQPFDRN-LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 237
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 163.31 bits (412), Expect = 2.237e-46
Identity = 81/114 (71.05%), Postives = 93/114 (81.58%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  125 SGKQELQPFDRN-LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 237
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Celegans
Match: pop-1 (pep chromosome:WBcel235:I:2823254:2830311:-1 gene:WBGene00004077.1 transcript:W10C8.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:pop-1)

HSP 1 Score: 105.531 bits (262), Expect = 2.203e-24
Identity = 49/82 (59.76%), Postives = 62/82 (75.61%), Query Frame = 3 
Query:  699 KKPHIKKPLNAFMLFMKEMRAKVVAECT--LKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYAT 938
            K  H+KKPLNAFM FMKE R  ++ E     K+SA +N+ LG+RWH LS+EEQAKY+EMA+K+KE H + YP WSAR+NYA 
Sbjct:  188 KDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAV 269
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Celegans
Match: gei-3 (GEX Interacting protein [Source:UniProtKB/TrEMBL;Acc:Q0G834])

HSP 1 Score: 66.6254 bits (161), Expect = 2.602e-11
Identity = 25/71 (35.21%), Postives = 50/71 (70.42%), Query Frame = 3 
Query:  702 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGW 914
            +PH+++P+NAFM+F K  R  V  +   K++  +++ILG  W++L+ +++A+Y+++A + KE H + +P W
Sbjct:  840 EPHVRRPMNAFMIFSKRHRPLVHQQYPNKDNRTVSKILGEWWYSLAADQKAEYHKLATQVKEAHFKAHPDW 910
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Celegans
Match: gei-3 (GEX Interacting protein [Source:UniProtKB/TrEMBL;Acc:Q0G834])

HSP 1 Score: 65.4698 bits (158), Expect = 3.967e-11
Identity = 25/71 (35.21%), Postives = 50/71 (70.42%), Query Frame = 3 
Query:  702 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGW 914
            +PH+++P+NAFM+F K  R  V  +   K++  +++ILG  W++L+ +++A+Y+++A + KE H + +P W
Sbjct:   75 EPHVRRPMNAFMIFSKRHRPLVHQQYPNKDNRTVSKILGEWWYSLAADQKAEYHKLATQVKEAHFKAHPDW 145
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Celegans
Match: egl-13 (Transcription factor egl-13 [Source:UniProtKB/Swiss-Prot;Acc:Q23045])

HSP 1 Score: 61.6178 bits (148), Expect = 3.230e-10
Identity = 37/107 (34.58%), Postives = 60/107 (56.07%), Query Frame = 3 
Query:  612 TPNSSGSNLSFPSTRNSLRFTFEENSEKP--KKP-HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSAR 923
            +PNSSG      ST  +   T E  + +P  K P HIK+P+NAFM++ ++ R K++       ++ I++ILG RW  +S  E+  YYE   +  +LH + +P +  R
Sbjct:  144 SPNSSGK-----STPGNTSVTSEVATPRPQAKSPNHIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYR 245
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Celegans
Match: egl-13 (Transcription factor egl-13 [Source:UniProtKB/Swiss-Prot;Acc:Q23045])

HSP 1 Score: 61.6178 bits (148), Expect = 3.341e-10
Identity = 37/107 (34.58%), Postives = 60/107 (56.07%), Query Frame = 3 
Query:  612 TPNSSGSNLSFPSTRNSLRFTFEENSEKP--KKP-HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSAR 923
            +PNSSG      ST  +   T E  + +P  K P HIK+P+NAFM++ ++ R K++       ++ I++ILG RW  +S  E+  YYE   +  +LH + +P +  R
Sbjct:  141 SPNSSGK-----STPGNTSVTSEVATPRPQAKSPNHIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYR 242
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0100246)

HSP 1 Score: 156.377 bits (394), Expect = 1.565e-42
Identity = 105/229 (45.85%), Postives = 140/229 (61.14%), Query Frame = 3 
Query:  291 AFYKQSNNQLFYPSISGNNLSTIA--QTNSMYSQD--LASWNSNPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQ 965
            A Y  +  Q  YP +S +++S +A   T S+YS       + S+ P ++  L S    R+        SPSLL  P V+ +++H+     S    +  K     Q     +T N    NL    T N+     +E +   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWHAL REEQAKYYE+AR+E++LH Q+YP WS+R N A++ K++K++Q
Sbjct:  145 ALYPFAGGQYPYPMLS-SDMSQVASWHTPSVYSASSFRTPYPSSLP-INTTLASDFPFRF--------SPSLL--PSVHATSHHV-INAHSAIVGVSSKQECGVQDP---TTNNRYPRNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALGREEQAKYYELARRERQLHMQMYPDWSSRTN-ASRGKKRKRKQ 356
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0308615)

HSP 1 Score: 157.532 bits (397), Expect = 2.273e-42
Identity = 75/111 (67.57%), Postives = 91/111 (81.98%), Query Frame = 3 
Query:  633 NLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQ 965
            NL    T N+     +E +   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWHAL REEQAKYYE+AR+E++LH Q+YP WS+R N A++ K++K++Q
Sbjct:  247 NLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALGREEQAKYYELARRERQLHMQMYPDWSSRTN-ASRGKKRKRKQ 356
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0112657)

HSP 1 Score: 160.999 bits (406), Expect = 4.228e-42
Identity = 74/101 (73.27%), Postives = 83/101 (82.18%), Query Frame = 3 
Query:  633 NLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            NL    T N+     +E +   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH LSREEQ+KYYE AR+E++LH +LYPGWSARDNY 
Sbjct:  688 NLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYG 788
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0334301)

HSP 1 Score: 159.073 bits (401), Expect = 7.424e-42
Identity = 74/101 (73.27%), Postives = 83/101 (82.18%), Query Frame = 3 
Query:  633 NLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            NL    T N+     +E +   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH LSREEQ+KYYE AR+E++LH +LYPGWSARDNY 
Sbjct:  247 NLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYG 347
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0089161)

HSP 1 Score: 159.073 bits (401), Expect = 8.198e-42
Identity = 74/101 (73.27%), Postives = 83/101 (82.18%), Query Frame = 3 
Query:  633 NLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            NL    T N+     +E +   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH LSREEQ+KYYE AR+E++LH +LYPGWSARDNY 
Sbjct:  247 NLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYG 347
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Zebrafish
Match: lef1 (lymphoid enhancer-binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-990714-26])

HSP 1 Score: 160.614 bits (405), Expect = 2.781e-47
Identity = 72/86 (83.72%), Postives = 80/86 (93.02%), Query Frame = 3 
Query:  678 EENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            +   ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:   16 QRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 101
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Zebrafish
Match: lef1 (lymphoid enhancer-binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-990714-26])

HSP 1 Score: 162.925 bits (411), Expect = 2.209e-45
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  257 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 338
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Zebrafish
Match: lef1 (lymphoid enhancer-binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-990714-26])

HSP 1 Score: 162.925 bits (411), Expect = 2.430e-45
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  258 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 339
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Zebrafish
Match: tcf7l1a (transcription factor 7 like 1a [Source:NCBI gene;Acc:30523])

HSP 1 Score: 164.466 bits (415), Expect = 3.115e-45
Identity = 73/82 (89.02%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+LSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  193 EEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG 274
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Zebrafish
Match: tcf7l1b (transcription factor 7 like 1b [Source:NCBI gene;Acc:30556])

HSP 1 Score: 163.31 bits (412), Expect = 6.344e-45
Identity = 72/79 (91.14%), Postives = 77/79 (97.47%), Query Frame = 3 
Query:  699 KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+LSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  193 KKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG 271
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Xenopus
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:100493178])

HSP 1 Score: 164.466 bits (415), Expect = 1.227e-45
Identity = 73/88 (82.95%), Postives = 82/88 (93.18%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQ 953
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + + Q
Sbjct:  277 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYKAEKRSQ 364
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Xenopus
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:100493178])

HSP 1 Score: 162.925 bits (411), Expect = 3.901e-45
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  264 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 345
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Xenopus
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:395061])

HSP 1 Score: 162.925 bits (411), Expect = 6.104e-45
Identity = 72/90 (80.00%), Postives = 84/90 (93.33%), Query Frame = 3 
Query:  693 KPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            +PKKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQ+KYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  244 EPKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQSKYYELARKERQLHMQLYPGWSARDNYGKRKRRTREK 333
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Xenopus
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:395061])

HSP 1 Score: 164.081 bits (414), Expect = 8.990e-45
Identity = 72/90 (80.00%), Postives = 84/90 (93.33%), Query Frame = 3 
Query:  693 KPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            +PKKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQ+KYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  244 EPKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQSKYYELARKERQLHMQLYPGWSARDNYGKRKRRTREK 333
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Xenopus
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:395061])

HSP 1 Score: 164.466 bits (415), Expect = 1.198e-44
Identity = 72/90 (80.00%), Postives = 84/90 (93.33%), Query Frame = 3 
Query:  693 KPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            +PKKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQ+KYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  273 EPKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQSKYYELARKERQLHMQLYPGWSARDNYGKRKRRTREK 362
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Mouse
Match: Tcf7 (transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507])

HSP 1 Score: 162.54 bits (410), Expect = 3.185e-47
Identity = 82/115 (71.30%), Postives = 94/115 (81.74%), Query Frame = 3 
Query:  621 SSGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SSG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:   68 SSGKQELQPYDRN-LKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 181
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Mouse
Match: Tcf7 (transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507])

HSP 1 Score: 164.466 bits (415), Expect = 1.801e-46
Identity = 82/115 (71.30%), Postives = 94/115 (81.74%), Query Frame = 3 
Query:  621 SSGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SSG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  158 SSGKQELQPYDRN-LKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 271
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Mouse
Match: Lef1 (lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770])

HSP 1 Score: 164.851 bits (416), Expect = 2.183e-46
Identity = 72/86 (83.72%), Postives = 80/86 (93.02%), Query Frame = 3 
Query:  678 EENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            +   ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  220 QRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 305
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Mouse
Match: Lef1 (lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770])

HSP 1 Score: 163.696 bits (413), Expect = 1.483e-45
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  262 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 343
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Mouse
Match: Tcf7 (transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507])

HSP 1 Score: 164.851 bits (416), Expect = 1.675e-45
Identity = 82/115 (71.30%), Postives = 94/115 (81.74%), Query Frame = 3 
Query:  621 SSGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SSG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  274 SSGKQELQPYDRN-LKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 387
[Close]
BLAST of Transcription factor 7-like 1 vs. UniProt/SwissProt
Match: sp|P36402|TCF7_HUMAN (Transcription factor 7 OS=Homo sapiens OX=9606 GN=TCF7 PE=1 SV=3)

HSP 1 Score: 164.851 bits (416), Expect = 5.927e-45
Identity = 83/122 (68.03%), Postives = 95/122 (77.87%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNT 986
            SG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++   S   T
Sbjct:  240 SGKQELQPFDRN-LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTET 360
[Close]
BLAST of Transcription factor 7-like 1 vs. UniProt/SwissProt
Match: sp|Q9QXN1|LEF1_RAT (Lymphoid enhancer-binding factor 1 OS=Rattus norvegicus OX=10116 GN=Lef1 PE=2 SV=1)

HSP 1 Score: 164.466 bits (415), Expect = 1.180e-44
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  290 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 371
[Close]
BLAST of Transcription factor 7-like 1 vs. UniProt/SwissProt
Match: sp|P27782|LEF1_MOUSE (Lymphoid enhancer-binding factor 1 OS=Mus musculus OX=10090 GN=Lef1 PE=1 SV=1)

HSP 1 Score: 164.466 bits (415), Expect = 1.193e-44
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  290 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 371
[Close]
BLAST of Transcription factor 7-like 1 vs. UniProt/SwissProt
Match: sp|Q00417|TCF7_MOUSE (Transcription factor 7 OS=Mus musculus OX=10090 GN=Tcf7 PE=1 SV=2)

HSP 1 Score: 164.851 bits (416), Expect = 1.221e-44
Identity = 82/115 (71.30%), Postives = 94/115 (81.74%), Query Frame = 3 
Query:  621 SSGSNLSFPSTRNSLRFTFEENSEK-PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            SSG     P  RN L+   E  +EK  KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + +R +++
Sbjct:  274 SSGKQELQPYDRN-LKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREK 387
[Close]
BLAST of Transcription factor 7-like 1 vs. UniProt/SwissProt
Match: sp|Q9UJU2|LEF1_HUMAN (Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1)

HSP 1 Score: 164.466 bits (415), Expect = 1.271e-44
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  292 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 373
[Close]
BLAST of Transcription factor 7-like 1 vs. TrEMBL
Match: A0A291LM08 (TCF-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 194.897 bits (494), Expect = 4.688e-53
Identity = 113/201 (56.22%), Postives = 133/201 (66.17%), Query Frame = 3 
Query:  387 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKR 950
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA  +KR
Sbjct:   38 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKR 237
[Close]
BLAST of Transcription factor 7-like 1 vs. TrEMBL
Match: A0A1S6KMJ0 (HMG box domain-containing protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 194.897 bits (494), Expect = 5.198e-53
Identity = 113/201 (56.22%), Postives = 133/201 (66.17%), Query Frame = 3 
Query:  387 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKR 950
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA  +KR
Sbjct:   44 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKR 243
[Close]
BLAST of Transcription factor 7-like 1 vs. TrEMBL
Match: A0A1B1M0Q0 (TCF/LEF OS=Platynereis dumerilii OX=6359 PE=2 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 2.231e-47
Identity = 92/168 (54.76%), Postives = 111/168 (66.07%), Query Frame = 3 
Query:  486 PSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTS 989
            P +L +P ++   NH   +T  P   +  ++     ++    TPN S S  S P                PK+PH+KKPLNAFMLFMKEMRA+V AECTLKESAAINQILGRRWHAL R EQAKYYEMARKEKELH QLYPGWSARDNYA   K++K+++  S+ N S
Sbjct:  205 PGMLPHPGMHPGLNHPAIITPGPKQEINSENHRPPYHHHHDHTPNDSDS--SHPDV-------------APKRPHVKKPLNAFMLFMKEMRAQVAAECTLKESAAINQILGRRWHALDRSEQAKYYEMARKEKELHMQLYPGWSARDNYAANSKKKKRKRETSVSNPS 357
[Close]
BLAST of Transcription factor 7-like 1 vs. TrEMBL
Match: A0A345CKB5 (Tcf C-terminal variant X5 (Fragment) OS=Platynereis dumerilii OX=6359 GN=Tcf PE=2 SV=1)

HSP 1 Score: 170.244 bits (430), Expect = 5.883e-47
Identity = 78/98 (79.59%), Postives = 87/98 (88.78%), Query Frame = 3 
Query:  696 PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTS 989
            PK+PH+KKPLNAFMLFMKEMRA+V AECTLKESAAINQILGRRWHAL R EQAKYYEMARKEKELH QLYPGWSARDNYA   K++K+++  S+ N S
Sbjct:   16 PKRPHVKKPLNAFMLFMKEMRAQVAAECTLKESAAINQILGRRWHALDRSEQAKYYEMARKEKELHMQLYPGWSARDNYAANSKKKKRKRETSVSNPS 113
[Close]
BLAST of Transcription factor 7-like 1 vs. TrEMBL
Match: A0A345CKB4 (Tcf C-terminal variant X4 (Fragment) OS=Platynereis dumerilii OX=6359 GN=Tcf PE=2 SV=1)

HSP 1 Score: 170.629 bits (431), Expect = 9.853e-47
Identity = 78/98 (79.59%), Postives = 87/98 (88.78%), Query Frame = 3 
Query:  696 PKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTS 989
            PK+PH+KKPLNAFMLFMKEMRA+V AECTLKESAAINQILGRRWHAL R EQAKYYEMARKEKELH QLYPGWSARDNYA   K++K+++  S+ N S
Sbjct:   16 PKRPHVKKPLNAFMLFMKEMRAQVAAECTLKESAAINQILGRRWHALDRSEQAKYYEMARKEKELHMQLYPGWSARDNYAANSKKKKRKRETSVSNPS 113
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Cavefish
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:103033630])

HSP 1 Score: 162.925 bits (411), Expect = 2.167e-45
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  262 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 343
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Cavefish
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:103033630])

HSP 1 Score: 162.925 bits (411), Expect = 3.367e-45
Identity = 72/82 (87.80%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PK+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  262 QEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 343
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Cavefish
Match: tcf7l2 (transcription factor 7 like 2 [Source:NCBI gene;Acc:103031257])

HSP 1 Score: 162.925 bits (411), Expect = 1.186e-44
Identity = 87/132 (65.91%), Postives = 102/132 (77.27%), Query Frame = 3 
Query:  561 NLYGKHSSLNQYNLFHS---TPN----SSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++   H SL+   + H    TPN    SS S++S   T NS +   ++  ++ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  273 HMVPPHHSLHTTGIPHPAIVTPNVKQESSHSDIS---TLNSSKHQDQKKEDEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYV 401
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Cavefish
Match: tcf7l1b (transcription factor 7-like 1-B [Source:NCBI gene;Acc:103022374])

HSP 1 Score: 164.851 bits (416), Expect = 1.324e-44
Identity = 73/82 (89.02%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+LSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  320 EEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG 401
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Cavefish
Match: tcf7l2 (transcription factor 7 like 2 [Source:NCBI gene;Acc:103031257])

HSP 1 Score: 163.696 bits (413), Expect = 1.537e-44
Identity = 88/133 (66.17%), Postives = 103/133 (77.44%), Query Frame = 3 
Query:  561 NLYGKHSSLNQYNLFHS---TPN----SSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYAT 938
            ++   H SL+   + H    TPN    SS S++S   T NS +   ++  ++ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNYA 
Sbjct:  298 HMVPPHHSLHTTGIPHPAIVTPNVKQESSHSDIS---TLNSSKHQDQKKEDEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYAA 427
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004973.1 (pep scaffold:Pmarinus_7.0:GL479925:4219:8952:-1 gene:ENSPMAG00000004519.1 transcript:ENSPMAT00000004973.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.5817 bits (218), Expect = 1.081e-21
Identity = 38/43 (88.37%), Postives = 41/43 (95.35%), Query Frame = 3 
Query:  807 QILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            QILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:    1 QILGRRWHALSREEQAKYYELARKERQLHSQLYPGWSARDNYG 43
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008165.1 (pep scaffold:Pmarinus_7.0:GL479973:18969:29522:-1 gene:ENSPMAG00000007384.1 transcript:ENSPMAT00000008165.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 65.855 bits (159), Expect = 6.684e-13
Identity = 30/74 (40.54%), Postives = 50/74 (67.57%), Query Frame = 3 
Query:  702 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSAR 923
            +PHIK+P+NAFM++ K+ R K++       +++I++ILG RW A+S +E+  YYE   +  +LH + YPG+  R
Sbjct:   58 EPHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKAMSSQEKQPYYEEQARLSKLHLERYPGYKYR 131
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006684.1 (pep scaffold:Pmarinus_7.0:GL477399:28105:35473:-1 gene:ENSPMAG00000006026.1 transcript:ENSPMAT00000006684.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.151 bits (139), Expect = 9.119e-10
Identity = 31/99 (31.31%), Postives = 57/99 (57.58%), Query Frame = 3 
Query:  621 SSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVV-AECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGW 914
            S+  ++   ++ +  R   E  S    +PHIK+P+NAFM++ K+ R K++ A   +K +  I++  G RW ++S +E+  YYE   +  +LH + YP +
Sbjct:   31 SANEDMEGSNSMSDARVFRESRSRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMKHTLQISECPGSRWKSMSNQEKQPYYEEQARLSKLHLEKYPDY 129
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Sea Lamprey
Match: sox10 (SRY-box transcription factor 10 [Source:ZFIN;Acc:ZDB-GENE-011207-1])

HSP 1 Score: 50.447 bits (119), Expect = 4.193e-7
Identity = 28/101 (27.72%), Postives = 55/101 (54.46%), Query Frame = 3 
Query:  663 LRFTFEENSEKP-KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKR 962
            +R        KP +KPH+K+P+NAFM++ +  R K+  +     +A +++ LG+ W  L+  E+  + E A + +  H + +P      +Y  Q +R+K++
Sbjct:   95 VRGAVGPGGCKPGEKPHVKRPMNAFMVWAQAARRKLSDQYPQLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRMQHKKDHP------DYKYQPRRRKQQ 189
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Sea Lamprey
Match: sox12 (SRY-box transcription factor 12 [Source:ZFIN;Acc:ZDB-GENE-040724-33])

HSP 1 Score: 50.0618 bits (118), Expect = 6.258e-7
Identity = 25/72 (34.72%), Postives = 40/72 (55.56%), Query Frame = 3 
Query:  708 HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSAR 923
            HIK+P+NAFM++ +  R K++ E     +A I++ LGRRW  L   E+  +   A + +  H   YP +  R
Sbjct:   59 HIKRPMNAFMVWSQIERRKIMMESPDVHNAEISKRLGRRWKQLKDCEKVPFMREAERLRLKHMADYPDYKYR 130
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Yeast
Match: ROX1 (Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance [Source:SGD;Acc:S000006269])

HSP 1 Score: 49.2914 bits (116), Expect = 7.652e-7
Identity = 24/75 (32.00%), Postives = 42/75 (56.00%), Query Frame = 3 
Query:  705 PHIKKPLNAFMLFMKEMRAKVVAECT-----LKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGW 914
            P I +P NAF+LF +     ++ E T     +  ++ I++I+G +W  L  E++A +  +A KEK  H + YP +
Sbjct:    8 PKIPRPKNAFILFRQHYHRILIDEWTAQGVEIPHNSNISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEY 82
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Nematostella
Match: EDO32618 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUJ9])

HSP 1 Score: 149.058 bits (375), Expect = 7.813e-44
Identity = 69/87 (79.31%), Postives = 75/87 (86.21%), Query Frame = 3 
Query:  681 ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQ 941
            E   K +  HIKKPLNAFML+MK+MR KVVAECTLKESAAINQILG++WHAL R EQAKYYEMARKE+ LH QLYPGWSARDNYA Q
Sbjct:    2 ERDSKLQLQHIKKPLNAFMLYMKDMRPKVVAECTLKESAAINQILGKKWHALDRSEQAKYYEMARKERALHLQLYPGWSARDNYAQQ 88
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Nematostella
Match: EDO47688 (Predicted protein; Sox family protein 2 [Source:UniProtKB/TrEMBL;Acc:Q3S383])

HSP 1 Score: 59.3066 bits (142), Expect = 4.159e-10
Identity = 28/84 (33.33%), Postives = 53/84 (63.10%), Query Frame = 3 
Query:  708 HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKK 959
            HIK+P+NA+M++ ++ R ++  EC    ++ I++ LG  W++L+ +E+  Y E A++ +ELH + +P      +Y  Q KR+ K
Sbjct:    7 HIKRPMNAYMVWSRKERRRIAEECPRMLNSEISKRLGLEWNSLTLDEKQPYVEEAKRLRELHKKDHP------DYKYQPKRKPK 84
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Nematostella
Match: EDO33516 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRZ8])

HSP 1 Score: 52.373 bits (124), Expect = 6.512e-9
Identity = 28/66 (42.42%), Postives = 41/66 (62.12%), Query Frame = 3 
Query:  711 IKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYP 908
            IK+PLNAF+L+ K+ R  +  E     +  I++ LG  W  L+ EE+A Y+E A+K KE H + YP
Sbjct:    6 IKRPLNAFILWSKKRRRVIANENPQMHNFDISRKLGLEWQKLTEEEKAYYFEEAKKLKEEHKERYP 71
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Nematostella
Match: EDO38755 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC09])

HSP 1 Score: 52.373 bits (124), Expect = 6.667e-9
Identity = 29/85 (34.12%), Postives = 50/85 (58.82%), Query Frame = 3 
Query:  699 KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQ 953
            KK H+K+P+N FM++ +E R +++ E     +A ++++LG  W  LS EE+  Y E A+   E+H + +P      +Y  Q KR+
Sbjct:    4 KKTHVKRPMNCFMVWSREKRCQILQENPGINNARLSKLLGMAWKKLSVEEKEPYIEKAKHLTEMHKEKHP------DYKYQPKRR 82
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Nematostella
Match: EDO32843 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STW6])

HSP 1 Score: 50.8322 bits (120), Expect = 2.341e-8
Identity = 26/78 (33.33%), Postives = 45/78 (57.69%), Query Frame = 3 
Query:  681 ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGW 914
            E+ +K    H+K+P+NAFM++ +  R K+  E     +A I++ LG+RW  LS  E+  + E + + +  H Q YP +
Sbjct:   13 ESKKKSDMQHVKRPMNAFMVWSQIERRKMAEEHPDMHNAEISKRLGKRWKLLSESEKRPFVEESERLRIRHMQAYPDY 90
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Medaka
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:101167344])

HSP 1 Score: 165.236 bits (417), Expect = 4.707e-46
Identity = 80/109 (73.39%), Postives = 89/109 (81.65%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQK----------KRQGLSMCNT 986
            ++PKKPHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + KR++          KR G S C  
Sbjct:  257 QEPKKPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKMQESATGGKRNGFSTCKA 365
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Medaka
Match: tcf7l1 (transcription factor 7 like 1 [Source:NCBI gene;Acc:100820729])

HSP 1 Score: 168.703 bits (426), Expect = 5.942e-46
Identity = 84/131 (64.12%), Postives = 100/131 (76.34%), Query Frame = 3 
Query:  624 SGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTSKIIKDLSKR 1016
            SG N+S PS ++ +    EE+    KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+LSREEQAKYYE+ARKE++LH QLYPGWSARDNY   ++     Q +  C ++      SK+
Sbjct:  304 SGDNIS-PSMKSPVPAKKEED----KKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY---VRTPSHSQQVQTCFSTVYFLSASKK 426
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Medaka
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:101167344])

HSP 1 Score: 164.081 bits (414), Expect = 9.932e-46
Identity = 78/104 (75.00%), Postives = 91/104 (87.50%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTSKIIK 1001
            ++PKKPHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHALSREEQAKYYE+ARKE++LH QLYPGWSARDNY  + KR++++   S   T + +K
Sbjct:  263 QEPKKPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKMQESATGTGQRMK 366
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Medaka
Match: tcf7l1 (transcription factor 7 like 1 [Source:NCBI gene;Acc:100820729])

HSP 1 Score: 164.081 bits (414), Expect = 3.058e-44
Identity = 73/82 (89.02%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+LSREEQAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  323 EEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYG 404
[Close]
BLAST of Transcription factor 7-like 1 vs. Ensembl Medaka
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:101162309])

HSP 1 Score: 157.918 bits (398), Expect = 2.071e-43
Identity = 70/82 (85.37%), Postives = 78/82 (95.12%), Query Frame = 3 
Query:  690 EKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 935
            ++PKKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+REEQAKYYE+ARKE++LH QLYP WSARDNY 
Sbjct:  276 KEPKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALTREEQAKYYELARKERQLHMQLYPTWSARDNYG 357
[Close]
BLAST of Transcription factor 7-like 1 vs. Planmine SMEST
Match: SMESG000059443.1 (SMESG000059443.1)

HSP 1 Score: 731.48 bits (1887), Expect = 0.000e+0
Identity = 388/388 (100.00%), Postives = 388/388 (100.00%), Query Frame = 3 
Query:  249 MVDDYCLQPTAIDQAFYKQSNNQLFYPSISGNNLSTIAQTNSMYSQDLASWNSNPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTSKIIKDLSKRDKGTRNNVGNQSWVKNNPMSNLPTQASQIANDATFQPKSHLTSESSKLHQNPNNYVXXXXXXXXXXXXXXXXXXXHVQLSADLESYNLSYGSQAFQNSFCPPTVNYPNQLPPIFDQTICQAIRLEQSAGRSN 1412
            MVDDYCLQPTAIDQAFYKQSNNQLFYPSISGNNLSTIAQTNSMYSQDLASWNSNPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTSKIIKDLSKRDKGTRNNVGNQSWVKNNPMSNLPTQASQIANDATFQPKSHLTSESSKLHQNPNNYVSSMMSPFSCSSFPIFSPPSHVQLSADLESYNLSYGSQAFQNSFCPPTVNYPNQLPPIFDQTICQAIRLEQSAGRSN
Sbjct:    1 MVDDYCLQPTAIDQAFYKQSNNQLFYPSISGNNLSTIAQTNSMYSQDLASWNSNPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGSNLSFPSTRNSLRFTFEENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTSKIIKDLSKRDKGTRNNVGNQSWVKNNPMSNLPTQASQIANDATFQPKSHLTSESSKLHQNPNNYVSSMMSPFSCSSFPIFSPPSHVQLSADLESYNLSYGSQAFQNSFCPPTVNYPNQLPPIFDQTICQAIRLEQSAGRSN 388
[Close]
BLAST of Transcription factor 7-like 1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 194.897 bits (494), Expect = 8.805e-57
Identity = 113/201 (56.22%), Postives = 133/201 (66.17%), Query Frame = 3 
Query:  387 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKR 950
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA  +KR
Sbjct:   44 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKR 243
[Close]
BLAST of Transcription factor 7-like 1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 195.282 bits (495), Expect = 1.178e-56
Identity = 113/201 (56.22%), Postives = 133/201 (66.17%), Query Frame = 3 
Query:  387 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKR 950
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA  +KR
Sbjct:   47 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKR 246
[Close]
BLAST of Transcription factor 7-like 1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 194.897 bits (494), Expect = 1.289e-56
Identity = 113/201 (56.22%), Postives = 133/201 (66.17%), Query Frame = 3 
Query:  387 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKR 950
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA  +KR
Sbjct:   44 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKR 243
[Close]
BLAST of Transcription factor 7-like 1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 194.897 bits (494), Expect = 1.403e-56
Identity = 113/201 (56.22%), Postives = 133/201 (66.17%), Query Frame = 3 
Query:  387 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYATQIKR 950
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA  +KR
Sbjct:   45 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKR 244
The following BLAST results are available for this feature:
BLAST of Transcription factor 7-like 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TCF78.856e-4865.35transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
TCF71.926e-4771.05transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
TCF78.719e-4765.38transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
TCF72.237e-4671.05transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
TCF72.237e-4671.05transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pop-12.203e-2459.76pep chromosome:WBcel235:I:2823254:2830311:-1 gene:... [more]
gei-32.602e-1135.21GEX Interacting protein [Source:UniProtKB/TrEMBL;... [more]
gei-33.967e-1135.21GEX Interacting protein [Source:UniProtKB/TrEMBL;... [more]
egl-133.230e-1034.58Transcription factor egl-13 [Source:UniProtKB/Swi... [more]
egl-133.341e-1034.58Transcription factor egl-13 [Source:UniProtKB/Swi... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pan1.565e-4245.85gene:FBgn0085432 transcript:FBtr0100246[more]
pan2.273e-4267.57gene:FBgn0085432 transcript:FBtr0308615[more]
pan4.228e-4273.27gene:FBgn0085432 transcript:FBtr0112657[more]
pan7.424e-4273.27gene:FBgn0085432 transcript:FBtr0334301[more]
pan8.198e-4273.27gene:FBgn0085432 transcript:FBtr0089161[more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef12.781e-4783.72lymphoid enhancer-binding factor 1 [Source:ZFIN;Ac... [more]
lef12.209e-4587.80lymphoid enhancer-binding factor 1 [Source:ZFIN;Ac... [more]
lef12.430e-4587.80lymphoid enhancer-binding factor 1 [Source:ZFIN;Ac... [more]
tcf7l1a3.115e-4589.02transcription factor 7 like 1a [Source:NCBI gene;A... [more]
tcf7l1b6.344e-4591.14transcription factor 7 like 1b [Source:NCBI gene;A... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef11.227e-4582.95lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
lef13.901e-4587.80lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf76.104e-4580.00transcription factor 7 [Source:NCBI gene;Acc:39506... [more]
tcf78.990e-4580.00transcription factor 7 [Source:NCBI gene;Acc:39506... [more]
tcf71.198e-4480.00transcription factor 7 [Source:NCBI gene;Acc:39506... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tcf73.185e-4771.30transcription factor 7, T cell specific [Source:MG... [more]
Tcf71.801e-4671.30transcription factor 7, T cell specific [Source:MG... [more]
Lef12.183e-4683.72lymphoid enhancer binding factor 1 [Source:MGI Sym... [more]
Lef11.483e-4587.80lymphoid enhancer binding factor 1 [Source:MGI Sym... [more]
Tcf71.675e-4571.30transcription factor 7, T cell specific [Source:MG... [more]
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BLAST of Transcription factor 7-like 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P36402|TCF7_HUMAN5.927e-4568.03Transcription factor 7 OS=Homo sapiens OX=9606 GN=... [more]
sp|Q9QXN1|LEF1_RAT1.180e-4487.80Lymphoid enhancer-binding factor 1 OS=Rattus norve... [more]
sp|P27782|LEF1_MOUSE1.193e-4487.80Lymphoid enhancer-binding factor 1 OS=Mus musculus... [more]
sp|Q00417|TCF7_MOUSE1.221e-4471.30Transcription factor 7 OS=Mus musculus OX=10090 GN... [more]
sp|Q9UJU2|LEF1_HUMAN1.271e-4487.80Lymphoid enhancer-binding factor 1 OS=Homo sapiens... [more]
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BLAST of Transcription factor 7-like 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A291LM084.688e-5356.22TCF-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
A0A1S6KMJ05.198e-5356.22HMG box domain-containing protein OS=Schmidtea med... [more]
A0A1B1M0Q02.231e-4754.76TCF/LEF OS=Platynereis dumerilii OX=6359 PE=2 SV=1[more]
A0A345CKB55.883e-4779.59Tcf C-terminal variant X5 (Fragment) OS=Platynerei... [more]
A0A345CKB49.853e-4779.59Tcf C-terminal variant X4 (Fragment) OS=Platynerei... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef12.167e-4587.80lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
lef13.367e-4587.80lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf7l21.186e-4465.91transcription factor 7 like 2 [Source:NCBI gene;Ac... [more]
tcf7l1b1.324e-4489.02transcription factor 7-like 1-B [Source:NCBI gene;... [more]
tcf7l21.537e-4466.17transcription factor 7 like 2 [Source:NCBI gene;Ac... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000004973.11.081e-2188.37pep scaffold:Pmarinus_7.0:GL479925:4219:8952:-1 ge... [more]
ENSPMAT00000008165.16.684e-1340.54pep scaffold:Pmarinus_7.0:GL479973:18969:29522:-1 ... [more]
ENSPMAT00000006684.19.119e-1031.31pep scaffold:Pmarinus_7.0:GL477399:28105:35473:-1 ... [more]
sox104.193e-727.72SRY-box transcription factor 10 [Source:ZFIN;Acc:Z... [more]
sox126.258e-734.72SRY-box transcription factor 12 [Source:ZFIN;Acc:Z... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ROX17.652e-732.00Heme-dependent repressor of hypoxic genes; mediate... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO326187.813e-4479.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476884.159e-1033.33Predicted protein; Sox family protein 2 [Source:U... [more]
EDO335166.512e-942.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387556.667e-934.12Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO328432.341e-833.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Transcription factor 7-like 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef14.707e-4673.39lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf7l15.942e-4664.12transcription factor 7 like 1 [Source:NCBI gene;Ac... [more]
lef19.932e-4675.00lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf7l13.058e-4489.02transcription factor 7 like 1 [Source:NCBI gene;Ac... [more]
tcf72.071e-4385.37transcription factor 7 [Source:NCBI gene;Acc:10116... [more]
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BLAST of Transcription factor 7-like 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000059443.10.000e+0100.00SMESG000059443.1[more]
SMESG000009225.18.805e-5756.22SMESG000009225.1[more]
SMESG000009225.11.178e-5656.22SMESG000009225.1[more]
SMESG000009225.11.289e-5656.22SMESG000009225.1[more]
SMESG000009225.11.403e-5656.22SMESG000009225.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003783 ID=SMED30003783|Name=Transcription factor 7-like 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1424bp
CTAAGGCAGTTTGAAAAGTTGAAAAAAATTACTTTTTTTCAGAAGCTTTT
ATCTTGGAAATTGGGCTCTACTTGAATTTTTTAATTTAATAAATCCATCA
AAGATATCATCGATATTGCAGTTATTGTTTTATCGTTTGTTTTTTCTTTA
TGAGAAATTTTTTTTTGTTTTTGTTTGGGTTTTTTTATTTCATCTCTTTT
CTATTTGTTGTGCACGGAAAAAACAATTGAAAATTAAGTAGAGAATCAAT
GGTGGATGACTATTGTTTGCAACCAACGGCTATCGATCAAGCGTTTTATA
AACAAAGTAACAATCAGCTATTCTATCCATCAATTTCGGGAAATAACTTG
TCGACAATAGCTCAAACGAATTCTATGTATTCACAAGATTTAGCATCATG
GAACTCCAACCCACCTTTAGTAGATTATAGATTGTTTTCCTCAAACAATA
TGAGGTATGGTCAAAGAAATAATGGAAACCTATCCCCATCTCTTTTATAT
AATCCATTGGTGAATGTTTCCAATAACCATTTGGGTTGTCTTACGGAATC
TCCTTTCACAAATCTTTATGGAAAACATTCATCTTTAAATCAGTATAACT
TATTTCATAGCACTCCTAATTCCAGTGGCTCCAATCTAAGCTTTCCATCA
ACAAGAAATTCTTTGAGATTCACATTTGAAGAGAATTCCGAAAAACCGAA
AAAGCCACATATCAAGAAACCACTGAATGCATTTATGCTTTTCATGAAAG
AAATGCGGGCAAAAGTAGTGGCTGAATGTACACTTAAGGAATCGGCAGCA
ATTAATCAAATTCTTGGCCGTAGATGGCACGCTCTTTCTAGAGAAGAACA
GGCCAAATATTATGAAATGGCTCGAAAAGAAAAAGAGCTTCATCATCAAT
TATATCCTGGGTGGTCTGCGAGAGATAATTATGCTACTCAAATTAAACGA
CAAAAAAAGCGACAAGGCTTATCAATGTGTAACACGTCTAAGATAATTAA
AGATCTTTCAAAACGGGATAAGGGGACTCGAAATAATGTTGGAAACCAAT
CCTGGGTCAAAAATAACCCAATGAGCAACTTACCAACTCAAGCATCACAA
ATAGCGAATGATGCCACTTTTCAACCGAAGTCACATTTGACATCAGAATC
GTCAAAATTGCACCAAAATCCCAACAATTACGTTTCTTCAATGATGTCCC
CATTCTCTTGCTCATCGTTTCCGATATTCTCACCCCCCTCTCATGTTCAG
CTATCCGCAGATCTCGAATCCTACAACCTTTCGTATGGTTCTCAAGCATT
TCAGAATAGTTTCTGTCCACCAACAGTTAATTATCCCAATCAATTGCCTC
CTATTTTCGATCAAACAATTTGTCAAGCAATTCGATTGGAACAATCAGCC
GGACGATCAAATTAATTGCACCAC
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protein sequence of SMED30003783-orf-1

>SMED30003783-orf-1 ID=SMED30003783-orf-1|Name=SMED30003783-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=389bp
MVDDYCLQPTAIDQAFYKQSNNQLFYPSISGNNLSTIAQTNSMYSQDLAS
WNSNPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTE
SPFTNLYGKHSSLNQYNLFHSTPNSSGSNLSFPSTRNSLRFTFEENSEKP
KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREE
QAKYYEMARKEKELHHQLYPGWSARDNYATQIKRQKKRQGLSMCNTSKII
KDLSKRDKGTRNNVGNQSWVKNNPMSNLPTQASQIANDATFQPKSHLTSE
SSKLHQNPNNYVSSMMSPFSCSSFPIFSPPSHVQLSADLESYNLSYGSQA
FQNSFCPPTVNYPNQLPPIFDQTICQAIRLEQSAGRSN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005667transcription factor complex
GO:0005634nucleus
Vocabulary: molecular function
TermDefinition
GO:0008134transcription factor binding
GO:0005515protein binding
GO:0003677DNA binding
GO:0003700transcription factor activity, sequence-specific DNA binding
GO:0008013beta-catenin binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
PLANA:0000461lateral branch
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036910HMG_box_dom_sf
IPR024940TCF/LEF
IPR009071HMG_box_dom
IPR002083MATH/TRAF_dom
Vocabulary: biological process
TermDefinition
GO:0016055Wnt signaling pathway
GO:0060070canonical Wnt signaling pathway
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006357regulation of transcription from RNA polymerase II promoter
GO:0007275multicellular organism development
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009071High mobility group box domainSMARTSM00398hmgende2coord: 154..224
e-value: 3.2E-23
score: 93.1
IPR009071High mobility group box domainPFAMPF00505HMG_boxcoord: 155..222
e-value: 2.1E-22
score: 79.3
IPR009071High mobility group box domainPROSITEPS50118HMG_BOX_2coord: 155..223
score: 15.957
IPR036910High mobility group box domain superfamilyGENE3DG3DSA:1.10.30.10coord: 153..239
e-value: 4.2E-25
score: 90.0
IPR036910High mobility group box domain superfamilySUPERFAMILYSSF47095HMG-boxcoord: 154..233
IPR024940Transcription factor TCF/LEFPANTHERPTHR10373TRANSCRIPTION FACTOR 7 FAMILY MEMBERcoord: 34..239
NoneNo IPR availablePANTHERPTHR10373:SF38PROTEIN PANGOLIN, ISOFORM Jcoord: 34..239
NoneNo IPR availableCDDcd01388SOX-TCF_HMG-boxcoord: 159..225
e-value: 4.42182E-35
score: 121.636