c-SKI_SMAD_bind domain-containing protein

Overview
Namec-SKI_SMAD_bind domain-containing protein
Smed IDSMED30003733
Length (bp)1799
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of c-SKI_SMAD_bind domain-containing protein (SMED30003733) t-SNE clustered cells

Violin plots show distribution of expression levels for c-SKI_SMAD_bind domain-containing protein (SMED30003733) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of c-SKI_SMAD_bind domain-containing protein (SMED30003733) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for c-SKI_SMAD_bind domain-containing protein (SMED30003733) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30003733

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30003733h1SMcG0019293 SmedASXL_002407SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30003733h1SMcG0019293 Contig48722uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30003733h1SMcG0019293 Contig48722newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30003733h1SMcG0019293 dd_Smed_v4_10921_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30003733h1SMcG0019293 dd_Smed_v4_10921_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30003733h1SMcG0019293 dd_Smed_v4_10921_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30003733h1SMcG0019293 dd_Smed_v4_10921_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30003733h1SMcG0019293 dd_Smed_v4_10921_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30003733h1SMcG0019293 dd_Smed_v6_10921_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKI (SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10896])

HSP 1 Score: 156.377 bits (394), Expect = 1.187e-39
Identity = 93/267 (34.83%), Postives = 140/267 (52.43%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELPPK----RSIHTSTNSPSFSE 1125
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +     ++      S+ +    +RV H+CFG+ KG++ P  Y+  +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LD++K++F            VS  PP     ++  TS+ SP+ SE
Sbjct:   93 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERS----VRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLSQDYT-GKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSE 348
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 137.887 bits (346), Expect = 1.203e-33
Identity = 77/231 (33.33%), Postives = 121/231 (52.38%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+ S+TE  T T+L    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F
Sbjct:  117 PSDSSTE-LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKF 335
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 137.502 bits (345), Expect = 1.403e-33
Identity = 77/231 (33.33%), Postives = 121/231 (52.38%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+ S+TE  T T+L    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F
Sbjct:  137 PSDSSTE-LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKF 355
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 137.502 bits (345), Expect = 1.721e-33
Identity = 77/231 (33.33%), Postives = 121/231 (52.38%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+ S+TE  T T+L    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F
Sbjct:  137 PSDSSTE-LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKF 355
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 137.502 bits (345), Expect = 1.721e-33
Identity = 77/231 (33.33%), Postives = 121/231 (52.38%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+ S+TE  T T+L    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F
Sbjct:  137 PSDSSTE-LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKF 355
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0343409)

HSP 1 Score: 135.191 bits (339), Expect = 1.020e-32
Identity = 72/197 (36.55%), Postives = 104/197 (52.79%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T L    I  F+  GE  LCLPQ LN +L +  +  IN   + +GI C++C  ++L       ILP  V   GLI++++AER+          ++ S+ N+   I S  +   + ++H   V H CFG+ +GI  P  Y++    CI+CLEC    SP  FVGH H++F     E   CHWGFDS NW  YL ++ D
Sbjct:  119 TKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAAL------LHRSDRNSYVPIES--LAKGALSFH---VYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKF-----ENHTCHWGFDSRNWHDYLHVALD 299
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0112717)

HSP 1 Score: 135.191 bits (339), Expect = 1.020e-32
Identity = 72/197 (36.55%), Postives = 104/197 (52.79%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T L    I  F+  GE  LCLPQ LN +L +  +  IN   + +GI C++C  ++L       ILP  V   GLI++++AER+          ++ S+ N+   I S  +   + ++H   V H CFG+ +GI  P  Y++    CI+CLEC    SP  FVGH H++F     E   CHWGFDS NW  YL ++ D
Sbjct:  119 TKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAAL------LHRSDRNSYVPIES--LAKGALSFH---VYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKF-----ENHTCHWGFDSRNWHDYLHVALD 299
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0112719)

HSP 1 Score: 135.191 bits (339), Expect = 1.020e-32
Identity = 72/197 (36.55%), Postives = 104/197 (52.79%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T L    I  F+  GE  LCLPQ LN +L +  +  IN   + +GI C++C  ++L       ILP  V   GLI++++AER+          ++ S+ N+   I S  +   + ++H   V H CFG+ +GI  P  Y++    CI+CLEC    SP  FVGH H++F     E   CHWGFDS NW  YL ++ D
Sbjct:  119 TKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAAL------LHRSDRNSYVPIES--LAKGALSFH---VYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKF-----ENHTCHWGFDSRNWHDYLHVALD 299
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0112718)

HSP 1 Score: 135.191 bits (339), Expect = 1.020e-32
Identity = 72/197 (36.55%), Postives = 104/197 (52.79%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T L    I  F+  GE  LCLPQ LN +L +  +  IN   + +GI C++C  ++L       ILP  V   GLI++++AER+          ++ S+ N+   I S  +   + ++H   V H CFG+ +GI  P  Y++    CI+CLEC    SP  FVGH H++F     E   CHWGFDS NW  YL ++ D
Sbjct:  119 TKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAAL------LHRSDRNSYVPIES--LAKGALSFH---VYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKF-----ENHTCHWGFDSRNWHDYLHVALD 299
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: fuss (gene:FBgn0039932 transcript:FBtr0301336)

HSP 1 Score: 85.8853 bits (211), Expect = 3.517e-17
Identity = 55/201 (27.36%), Postives = 97/201 (48.26%), Query Frame = 1 
Query:  385 ENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQ-EFGSKWSETEVCHWGFDSSNWRWYLRLS 981
            E  +  LL    I S + +G++ LCL QI N LLK    ++I+    ++GI C +C   +L +L +   +P     CG+I++  AER+ K F           + +N   T  ++  D A      V H C    +G   P +Y  + A+CI+C  C    SP+ F+ H+H+     ++ + +  ++    ++WR ++ LS
Sbjct:   24 EKVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPVSSRRCGMITRREAERLCKSF-----------LGDN---TPPRLPDDFA----FNVQHKCAWGCRGSFLPSRYNSSRAKCIKCSYCGMFFSPNKFIFHSHRITTNDRYVQPDAANF----NSWRRHMSLS 202
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skila (SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GENE-070912-548])

HSP 1 Score: 154.451 bits (389), Expect = 6.976e-41
Identity = 83/230 (36.09%), Postives = 127/230 (55.22%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P  S+TE  T++LL    I+ F   GEK LCLPQ+LN +L++  +  IN   + + + C+ CD E+L +L    ILP     CGLI+ ++A+R+       G +I++   + N+ +    +  +S A  Q  V H C G+ +G+  P  Y   +A CI+C+EC  + SP +FV H+H     K  +   CHWGFDS+ W  YL+L      T+ EE  L   LDE+K++F
Sbjct:  147 PCDSSTE-LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGANISA---DPNSKLPGQGLLKESDASFQ--VEHQCLGKCQGLFVPHFYVQPDAPCIQCMECQLLFSPQNFVMHSH-----KSPDKRTCHWGFDSAKWPCYLQLGRKHEGTQ-EEPQLKQLLDEMKEKF 364
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skila (SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GENE-070912-548])

HSP 1 Score: 154.066 bits (388), Expect = 9.582e-41
Identity = 83/230 (36.09%), Postives = 127/230 (55.22%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P  S+TE  T++LL    I+ F   GEK LCLPQ+LN +L++  +  IN   + + + C+ CD E+L +L    ILP     CGLI+ ++A+R+       G +I++   + N+ +    +  +S A  Q  V H C G+ +G+  P  Y   +A CI+C+EC  + SP +FV H+H     K  +   CHWGFDS+ W  YL+L      T+ EE  L   LDE+K++F
Sbjct:  126 PCDSSTE-LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGANISA---DPNSKLPGQGLLKESDASFQ--VEHQCLGKCQGLFVPHFYVQPDAPCIQCMECQLLFSPQNFVMHSH-----KSPDKRTCHWGFDSAKWPCYLQLGRKHEGTQ-EEPQLKQLLDEMKEKF 343
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skila (SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GENE-070912-548])

HSP 1 Score: 155.992 bits (393), Expect = 3.691e-40
Identity = 95/279 (34.05%), Postives = 143/279 (51.25%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTN 1200
            P  S+TE  T++LL    I+ F   GEK LCLPQ+LN +L++  +  IN   + + + C+ CD E+L +L    ILP     CGLI+ ++A+R+       G +I++   + N+ +    +  +S A  Q  V H C G+ +G+  P  Y   +A CI+C+EC  + SP +FV H+H     K  +   CHWGFDS+ W  YL+L      T+ EE  L   LDE+K++F   +     K S+  S  S SF+      LH S  VF +    I     
Sbjct:  101 PCDSSTE-LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGANISA---DPNSKLPGQGLLKESDASFQ--VEHQCLGKCQGLFVPHFYVQPDAPCIQCMECQLLFSPQNFVMHSH-----KSPDKRTCHWGFDSAKWPCYLQLGRKHEGTQ-EEPQLKQLLDEMKEKFHYQLKRPLDKVSVFLSCMS-SFASCSQVDLH-SSLVFSRLFPDIKEEPG 365
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skib (v-ski avian sarcoma viral oncogene homolog b [Source:ZFIN;Acc:ZDB-GENE-990715-10])

HSP 1 Score: 152.91 bits (385), Expect = 7.859e-39
Identity = 90/260 (34.62%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELPPKRSIHTSTNSPS 1116
            P+  +TE    T+L +  I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI+Q++AER+       G     ++   + +I  ++           +V H+CFG+ KG+  P  YT  NA CI+CL+C  M     FV H+H+       E   CHWGFDSSNWR Y+ L +D +  K E  +L   L E+K +F           + S +P K+  H  + SPS
Sbjct:   72 PSDRSTER-CETVLERETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFSAPSCGLITQTDAERLCNALIYGGTFPPHADKELSCSIELERTEKS------FKVYHECFGKCKGLFVPELYTSPNAACIQCLDCRLMFPTHKFVVHSHKRL-----ENRTCHWGFDSSNWRAYILLDQDYS-EKEENSTLQQLLTELKGKFEMGNKHKTSYKAYSPIPSKKLKHDRSRSPS 318
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skia (v-ski avian sarcoma viral oncogene homolog a [Source:ZFIN;Acc:ZDB-GENE-990715-9])

HSP 1 Score: 150.214 bits (378), Expect = 9.054e-38
Identity = 85/230 (36.96%), Postives = 125/230 (54.35%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G     S+     +I  + +T  S      ++ H+CFG+ KG++ P  YT  NA CI+C++C  M     FV H+H+       E   CHWGFDS+NWR Y+ LS D T  K E+  L   LD+IK++F
Sbjct:   76 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNTVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFAAPSCGLITKTDAERLCNALIYGGTYPPHSKKELYGSIELE-LTEKS-----FKIYHECFGKCKGLLVPELYTSPNAPCIQCMDCRLMYPTHKFVVHSHKSL-----ENRTCHWGFDSANWRAYVLLSPDYT-GKEEKARLEQLLDDIKEKF 292
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: SKI (SKI proto-oncogene [Source:NCBI gene;Acc:100486949])

HSP 1 Score: 147.902 bits (372), Expect = 6.790e-37
Identity = 80/232 (34.48%), Postives = 124/232 (53.45%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEES--LNDYLDEIKKRF 1053
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + + C+ C  ++L +L    ILP     CGLI++++AER+       G         ++      ++    +++   RV H+CFG+ +G+  P  Y H +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ L+ D      EEE   L+  L+E+K++F
Sbjct:   76 PSDRSTER-CETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHVYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGSYPPRCAKKSDFPPGPLELELTESSF---RVYHECFGKCRGLFVPELYGHPSAPCIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLARDNPGAGGEEEQARLSRLLEEMKEKF 298
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000042147.1 (SKI-like proto-oncogene [Source:NCBI gene;Acc:100492636])

HSP 1 Score: 136.732 bits (343), Expect = 2.084e-33
Identity = 80/231 (34.63%), Postives = 119/231 (51.52%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+ S+TE  T T L    I+ F   GEK LCLPQ+LN +L++  +  IN   + M I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   N++   K T  +       V HDC G+ +G+  P  ++  +A CI+CLEC  M S   FV H+H     +  +   CHWGFDS+ W  Y+ LS     T  E + +N  L E+K++F
Sbjct:  119 PSDSSTE-LTQTELEGESISCFMVGGEKRLCLPQVLNSVLRDFSLQQINIVCDEMYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPQTFPQNGSLLPAKNSLAQLKETGSA-----FEVEHDCLGKCQGLFAPHLFSQPDAPCIQCLECYGMFSTQTFVMHSH-----RSPDKRTCHWGFDSAKWHCYVHLSPKYLDTP-EGKKMNALLKEMKEKF 337
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: arg1 (arginase 1 [Source:Xenbase;Acc:XB-GENE-966913])

HSP 1 Score: 93.5893 bits (231), Expect = 1.610e-20
Identity = 68/231 (29.44%), Postives = 112/231 (48.48%), Query Frame = 1 
Query:  310 TND----TVNSTEELESDIRSKSPNSSTTEN-FTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSE 984
            TND    +  ST   +S  +S+S +S    N  +  +L    I S   DG++ LCL QI N LLKN   ++I+    ++GI C +C   +L +L +   +P     CG+I++  AER+ K F             N      D    D        V+H+C    +G   P +Y  + A+CI+C  C+   SP+ F+ H+H+   +K+ + +  +  F+S  WR +L+LS+
Sbjct:    9 TNDILLASTASTYPQDSLSQSRSGHSGMKPNQVSQVILYGIPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLG----------ENRPPKLPDNFAFD--------VSHECAWGCRGSFIPARYNSSRAKCIKCTYCNMYFSPNKFIFHSHRTPEAKYMQPDAAN--FNS--WRRHLKLSD 217
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: SKOR1 (SKI family transcriptional corepressor 1 [Source:NCBI gene;Acc:100491438])

HSP 1 Score: 92.0485 bits (227), Expect = 7.586e-19
Identity = 55/196 (28.06%), Postives = 96/196 (48.98%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSE 984
            T L    I S   DG++ LCL QI N LLK+   ++I+    ++GI C +C   +L +L +   +P     CG+I++  AER+ K F     +    ++  N                   V H+C    +G   P +Y  + A+CI+C  C    SP+ F+ H+H+   SK+++ +  ++    ++WR +LRL++
Sbjct:   40 TCLYGVPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLG---EHRPPKLPENFAFD---------------VAHECAWGCRGSFIPARYNSSRAKCIKCAYCGLYFSPNKFIFHSHRTPDSKYTQPDAANF----NSWRRHLRLND 213
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: SKOR1 (SKI family transcriptional corepressor 1 [Source:NCBI gene;Acc:100491438])

HSP 1 Score: 92.0485 bits (227), Expect = 8.475e-19
Identity = 55/196 (28.06%), Postives = 96/196 (48.98%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSE 984
            T L    I S   DG++ LCL QI N LLK+   ++I+    ++GI C +C   +L +L +   +P     CG+I++  AER+ K F     +    ++  N                   V H+C    +G   P +Y  + A+CI+C  C    SP+ F+ H+H+   SK+++ +  ++    ++WR +LRL++
Sbjct:   40 TCLYGVPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLG---EHRPPKLPENFAFD---------------VAHECAWGCRGSFIPARYNSSRAKCIKCAYCGLYFSPNKFIFHSHRTPDSKYTQPDAANF----NSWRRHLRLND 213
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Ski (ski sarcoma viral oncogene homolog (avian) [Source:MGI Symbol;Acc:MGI:98310])

HSP 1 Score: 155.606 bits (392), Expect = 1.505e-39
Identity = 95/267 (35.58%), Postives = 141/267 (52.81%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELP----PKRSIHTSTNSPSFSE 1125
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +     ++      S+ +    +RV H+CFG+ KG++ P  Y+  +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LD++K++F            VSE P    PK +  TS+ SP+ SE
Sbjct:   93 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERS----VRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLSQDYT-GKEEQARLGRCLDDVKEKFDYANKYKRRVPRVSEPPASIRPK-TDDTSSQSPASSE 347
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Ski (ski sarcoma viral oncogene homolog (avian) [Source:MGI Symbol;Acc:MGI:98310])

HSP 1 Score: 152.525 bits (384), Expect = 1.208e-38
Identity = 90/249 (36.14%), Postives = 133/249 (53.41%), Query Frame = 1 
Query:  421 IASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELP----PKRSIHTSTNSPSFSE 1125
            I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +     ++      S+ +    +RV H+CFG+ KG++ P  Y+  +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LD++K++F            VSE P    PK +  TS+ SP+ SE
Sbjct:   58 ISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERS----VRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLSQDYT-GKEEQARLGRCLDDVKEKFDYANKYKRRVPRVSEPPASIRPK-TDDTSSQSPASSE 295
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Skil (SKI-like [Source:MGI Symbol;Acc:MGI:106203])

HSP 1 Score: 140.584 bits (353), Expect = 3.748e-35
Identity = 83/256 (32.42%), Postives = 131/256 (51.17%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEV 1128
            P+ S+TE  T TLL    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F          + I + T++PS  E+
Sbjct:   54 PSDSSTE-LTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKFSMRNG-----KRIQSKTDTPSGMEL 292
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Skil (SKI-like [Source:MGI Symbol;Acc:MGI:106203])

HSP 1 Score: 140.969 bits (354), Expect = 6.165e-35
Identity = 83/256 (32.42%), Postives = 131/256 (51.17%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEV 1128
            P+ S+TE  T TLL    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F          + I + T++PS  E+
Sbjct:  134 PSDSSTE-LTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKFSMRNG-----KRIQSKTDTPSGMEL 372
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Skil (SKI-like [Source:MGI Symbol;Acc:MGI:106203])

HSP 1 Score: 140.584 bits (353), Expect = 1.190e-34
Identity = 83/256 (32.42%), Postives = 131/256 (51.17%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERML-KFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEV 1128
            P+ S+TE  T TLL    I+ F   GEK LCLPQ+LN +L+   +  IN   + + I C+ C  ++L +L    ILP     CGLI+ ++A+R+            N S +   +++   K T  +       V H+C G+ +G+  P  Y   +A CI+CLEC  M +P  FV H+H     +  +   CHWGF+S+ W  YL +++    T  EE+ L   L+E+K++F          + I + T++PS  E+
Sbjct:  134 PSDSSTE-LTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSA-----FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSH-----RSPDKRTCHWGFESAKWHCYLHVNQKYLGTP-EEKKLKIILEEMKEKFSMRNG-----KRIQSKTDTPSGMEL 372
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|P17863|SKI_AVIES (Transforming protein Ski OS=Avian erythroblastosis virus (strain Sloan-Kettering) OX=11862 GN=V-SKI PE=1 SV=1)

HSP 1 Score: 153.295 bits (386), Expect = 2.053e-39
Identity = 86/230 (37.39%), Postives = 129/230 (56.09%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +   ++TI  + +T  S      +V H+CFG+ KG++ P  Y++ +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LDE+K++F
Sbjct:   55 PSDRSTER-CETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGTYPPHCKKEFSSTIELE-LTEKS-----FKVYHECFGKCKGLLVPELYSNPSAACIQCLDCRLMYPPHKFVVHSHKSL-----ENRTCHWGFDSANWRSYILLSQDYT-GKEEKARLGQLLDEMKEKF 271
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|P12755|SKI_HUMAN (Ski oncogene OS=Homo sapiens OX=9606 GN=SKI PE=1 SV=1)

HSP 1 Score: 156.377 bits (394), Expect = 5.701e-39
Identity = 93/267 (34.83%), Postives = 140/267 (52.43%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELPPK----RSIHTSTNSPSFSE 1125
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +     ++      S+ +    +RV H+CFG+ KG++ P  Y+  +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LD++K++F            VS  PP     ++  TS+ SP+ SE
Sbjct:   93 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERS----VRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLSQDYT-GKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSE 348
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|Q60698|SKI_MOUSE (Ski oncogene OS=Mus musculus OX=10090 GN=Ski PE=1 SV=2)

HSP 1 Score: 155.606 bits (392), Expect = 8.546e-39
Identity = 95/267 (35.58%), Postives = 141/267 (52.81%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELP----PKRSIHTSTNSPSFSE 1125
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +     ++      S+ +    +RV H+CFG+ KG++ P  Y+  +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LD++K++F            VSE P    PK +  TS+ SP+ SE
Sbjct:   91 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERS----VRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLSQDYT-GKEEQARLGRCLDDVKEKFDYANKYKRRVPRVSEPPASIRPK-TDDTSSQSPASSE 345
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|P49140|SKI_CHICK (Ski oncogene OS=Gallus gallus OX=9031 GN=SKI PE=1 SV=1)

HSP 1 Score: 154.836 bits (390), Expect = 2.007e-38
Identity = 86/230 (37.39%), Postives = 129/230 (56.09%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G      +   ++TI  + +T  S      +V H+CFG+ KG++ P  Y++ +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LDE+K++F
Sbjct:   76 PSDRSTER-CETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGTYPPHCKKEFSSTIELE-LTEKS-----FKVYHECFGKCKGLLVPELYSNPSAACIQCLDCRLMYPPHKFVVHSHKSL-----ENRTCHWGFDSANWRSYILLSQDYT-GKEEKARLGQLLDEMKEKF 292
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9TUG2|SKI_HORSE (Ski oncogene OS=Equus caballus OX=9796 GN=SKI PE=2 SV=1)

HSP 1 Score: 152.525 bits (384), Expect = 9.109e-38
Identity = 90/260 (34.62%), Postives = 136/260 (52.31%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF---------CTSVSELPPKRSIHTSTNSPS 1116
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + +   C+ C  ++L +L    ILP     CGLI++++AER+       G      +     ++      S+ +    +RV H+CFG+ KG++ P  Y+  +A CI+CL+C  M  P  FV H+H+       E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LD++K++F            VS  PP  SI  + ++PS
Sbjct:   93 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHTYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERS----VRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKAL-----ENRTCHWGFDSANWRAYILLSQDYT-GKEEQTRLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPA-SIRKTDDTPS 340
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A1S6KMI8 (c-SKI_SMAD_bind domain-containing protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 1053.12 bits (2722), Expect = 0.000e+0
Identity = 522/522 (100.00%), Postives = 522/522 (100.00%), Query Frame = 1 
Query:   55 MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLMRYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDIRSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKXXXXXXXXXXRQEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIECCDSSGENTLILDSPNTNTTIE 1620
            MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLMRYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDIRSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKLQLLNALFLLRQEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIECCDSSGENTLILDSPNTNTTIE
Sbjct:    1 MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLMRYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDIRSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKLQLLNALFLLRQEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIECCDSSGENTLILDSPNTNTTIE 522
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A158QGJ7 (c-SKI_SMAD_bind domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS202 PE=4 SV=1)

HSP 1 Score: 172.17 bits (435), Expect = 1.937e-41
Identity = 86/206 (41.75%), Postives = 124/206 (60.19%), Query Frame = 1 
Query:  382 TENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSD---KITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T    Y+++    +  FN  GE  LCLP +L  +L ++DI +I +A++ + I CT+C + +L++LH  N LP +VT CGLI +S+AERMLKF  S       ++    ++ +S+    I  +++  + I V HDCFG +KG I+P  YT  N+ CI C  C+K+ SP DFVGHTH    S       CHWGFDS+NWR YL+L  D
Sbjct:  145 TGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSQRQLTMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADTQQQSSESSEGFMAIKEETSLGNYIDVRHDCFGSEKGRIYPHLYTSVNSPCIACRTCNKLFSPQDFVGHTH----SVNESDSCCHWGFDSTNWRSYLQLDID 346
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A564YIK6 (c-SKI_SMAD_bind domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6350 PE=4 SV=1)

HSP 1 Score: 170.629 bits (431), Expect = 6.754e-41
Identity = 87/206 (42.23%), Postives = 121/206 (58.74%), Query Frame = 1 
Query:  382 TENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSI--GIDINSSEMNNNNTITSDKITSDSAAY-HQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T    Y+++    +  FN  GE  LCLP +L  +L ++DI +I +A++ + I CT+C   +L++LH  N LP +VT CGLI +S+AERMLKF  S      +  +E+    +    K   + A+  + I V HDCFG +KG I+P  Y  AN+ CI C  C+K+ SP DFVGHTH    S       CHWGFDS+NWR YL+L  D
Sbjct:  144 TGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSHRQLAMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADAEIRPPESAEGLKTAKEEASLGNYIDVRHDCFGTEKGRIYPHLYASANSPCIACRTCNKLFSPQDFVGHTHSVNESD----SCCHWGFDSTNWRSYLQLDID 345
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A564YIS2 (c-SKI_SMAD_bind domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6350 PE=4 SV=1)

HSP 1 Score: 170.244 bits (430), Expect = 6.942e-41
Identity = 87/206 (42.23%), Postives = 121/206 (58.74%), Query Frame = 1 
Query:  382 TENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSI--GIDINSSEMNNNNTITSDKITSDSAAY-HQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T    Y+++    +  FN  GE  LCLP +L  +L ++DI +I +A++ + I CT+C   +L++LH  N LP +VT CGLI +S+AERMLKF  S      +  +E+    +    K   + A+  + I V HDCFG +KG I+P  Y  AN+ CI C  C+K+ SP DFVGHTH    S       CHWGFDS+NWR YL+L  D
Sbjct:  144 TGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSHRQLAMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADAEIRPPESAEGLKTAKEEASLGNYIDVRHDCFGTEKGRIYPHLYASANSPCIACRTCNKLFSPQDFVGHTHSVNESD----SCCHWGFDSTNWRSYLQLDID 345
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A0R3SIW8 (c-SKI_SMAD_bind domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS4881 PE=4 SV=1)

HSP 1 Score: 170.629 bits (431), Expect = 7.124e-41
Identity = 87/206 (42.23%), Postives = 121/206 (58.74%), Query Frame = 1 
Query:  382 TENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSI--GIDINSSEMNNNNTITSDKITSDSAAY-HQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            T    Y+++    +  FN  GE  LCLP +L  +L ++DI +I +A++ + I CT+C   +L++LH  N LP +VT CGLI +S+AERMLKF  S      +  +E+    +    K   + A+  + I V HDCFG +KG I+P  Y  AN+ CI C  C+K+ SP DFVGHTH    S       CHWGFDS+NWR YL+L  D
Sbjct:  144 TGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSHRQLAMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADAEIRPPESAEGLKTAKEEASLGNYIDVRHDCFGTEKGRIYPHLYASANSPCIACRTCNKLFSPQDFVGHTH----SVNESDSCCHWGFDSTNWRSYLQLDID 345
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skila (SKI like proto-oncogene [Source:NCBI gene;Acc:103032490])

HSP 1 Score: 145.206 bits (365), Expect = 2.819e-36
Identity = 82/230 (35.65%), Postives = 120/230 (52.17%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+ S+TE  T+++L    I+ F   GEK LCLPQ+LN +L++  +  IN   + + + C+ CD E+L +L    ILP     CGLI+ ++A+R+       G  I+  +        S     DS A  Q  V H C G+ +G+  P  Y   +A CI C+EC  + SP +FV H+H        +   CHWGFDS+ W  YL+LS    +   EE  L   LDE+K +F
Sbjct:  142 PSDSSTE-LTHSILEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGTAIHVEQ--------SMLKAKDSEAGFQ--VEHQCLGKCQGLFVPQFYVQPDAPCIRCMECQLLFSPQNFVMHSHCS-----PDKRTCHWGFDSAKWACYLQLSRR-YQGAAEEPKLRQLLDEMKNKF 354
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skib (ski oncogene-like [Source:NCBI gene;Acc:103031474])

HSP 1 Score: 142.895 bits (359), Expect = 3.202e-35
Identity = 82/244 (33.61%), Postives = 121/244 (49.59%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF----CTSVSELPPKRSIHTSTNSPS 1116
            T+L +  I+ F   GEK LCLPQILN +L++  +  IN   + + + C+ C  E+L VL    +LP     CGLI+Q++AER+       G   +          T+DK          + V H+CFG+  G+  P  Y+   A C++C +C  M     FV H+H     +  E   CHWGFDS+NWR Y+ L  D      E   L   LD +K++F     T+ + +P K+S     +SPS
Sbjct:   83 TVLERETISCFVVGGEKRLCLPQILNTVLRDFSLQQINAVCDELHVYCSRCTAEQLEVLKVVGVLPFSAPSCGLITQTDAERLCNALVHGGALPSRGGPAALELATTDK---------SVPVYHECFGRCDGVFVPELYSGPGAACVQCADCGLMFPARRFVVHSH-----RRRENRTCHWGFDSANWRAYILLDRD-RAPPTEHTELQRRLDRLKEKFQPTKPTAYNPIPSKKSKQEHLHSPS 311
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skia (ski oncogene [Source:NCBI gene;Acc:103046211])

HSP 1 Score: 140.198 bits (352), Expect = 1.745e-34
Identity = 77/216 (35.65%), Postives = 113/216 (52.31%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFT-SIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWY--LRLSEDCTRTK 1002
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L+ + +  IN   + + I C+ C  E+L +L    +LP     CGLI++++AER+        G      ++     + ++    +  A   I+V H+CFG+  G++ P  YT  +A CI C  C  +++P  FV H H   G+   E   CHWGFDS NWR Y  LR SE   R+K
Sbjct:   98 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNTVLRELSLQQINSVCDQLHIYCSRCTAEQLEILKVVGVLPFSAPSCGLITKTDAERLCNALVHGAGY---PGKLAQEQEVEAE--VHEGKAEAGIKVYHECFGRCAGVLLPELYTSPSAPCIRCAHCGLLLAPRRFVAHAH---GT--PENRTCHWGFDSDNWRAYVLLRASEYAGRSK 302
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skib (ski oncogene-like [Source:NCBI gene;Acc:103031474])

HSP 1 Score: 139.813 bits (351), Expect = 3.187e-34
Identity = 75/219 (34.25%), Postives = 109/219 (49.77%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            T+L +  I+ F   GEK LCLPQILN +L++  +  IN   + + + C+ C  E+L VL    +LP     CGLI+Q++AER+       G   +          T+DK          + V H+CFG+  G+  P  Y+   A C++C +C  M     FV H+H     +  E   CHWGFDS+NWR Y+ L  D      E   L   LD +K++F
Sbjct:   83 TVLERETISCFVVGGEKRLCLPQILNTVLRDFSLQQINAVCDELHVYCSRCTAEQLEVLKVVGVLPFSAPSCGLITQTDAERLCNALVHGGALPSRGGPAALELATTDK---------SVPVYHECFGRCDGVFVPELYSGPGAACVQCADCGLMFPARRFVVHSH-----RRRENRTCHWGFDSANWRAYILLDRD-RAPPTEHTELQRRLDRLKEKF 286
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skilb (ski-like protein [Source:NCBI gene;Acc:103027845])

HSP 1 Score: 120.939 bits (302), Expect = 2.127e-28
Identity = 68/230 (29.57%), Postives = 110/230 (47.83%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+SST  +     L    I+ F+  GE  LCLPQ+LN +L++  +  IN   + + + C+ CD  +L VL    +LP     CGLI+ ++A+R+       G     + +   +++  D+            V H C G+ +G+  P  Y    + CI C +C ++  P  FV H+H +      +   CHWGFDS+ W  YL+L     +   EE  L   L+ +K +F
Sbjct:  119 PDSST--DLVVCNLEGETISCFSVGGELRLCLPQVLNTVLRDFSLHQINSVCDQLYLYCSRCDASQLQVLKILGVLPPGAPSCGLITLTDAQRLCNTLLHPGESNAPAGVLKGHSVGEDEEKEAEEGG-AFWVEHQCLGKCQGLFVPRFYASPGSPCIRCSQCRRLFCPERFVMHSHWQ-----PDKRTCHWGFDSAKWACYLQLGRR-YQGATEEARLKQLLETMKMKF 339
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001301.1 (pep scaffold:Pmarinus_7.0:GL481803:9978:11426:-1 gene:ENSPMAG00000001172.1 transcript:ENSPMAT00000001301.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 92.8189 bits (229), Expect = 2.154e-20
Identity = 60/219 (27.40%), Postives = 103/219 (47.03%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
             LL    I S   DG++ LCL QI N LLK+   ++I+    ++GI C +C   +L +L +   +P     CG+I++  AER+ K F     D     +  N                   VTH+C    +G   P +Y  + A+CI+C  C    SP+ F+ H+H+   +K+ + +  ++    ++WR +LRL++     K   E +    +++K  F
Sbjct:   11 VLLYGAPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNRRVALGITCVQCTPVQLELLRRAGAMPVSSRRCGMITRREAERLCKSFLG---DHEPPRLPENFAFD---------------VTHECAWGCRGSFVPARYNSSRAKCIKCSLCGLFFSPNKFIFHSHRAPDAKYVQPDAANF----NSWRRHLRLTD-----KAPSEDMVCAWEDVKAMF 202
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Nematostella
Match: EDO41836 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S373])

HSP 1 Score: 99.3673 bits (246), Expect = 2.356e-24
Identity = 59/183 (32.24%), Postives = 86/183 (46.99%), Query Frame = 1 
Query:  442 GEKLLCLPQIL-NLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSED 987
            GEK LC  +++  +LK      IN   + + I C  C  ++L VL    +LP      GLI++S+A R++   T   +   +S +           + DS     + V H+CFG   G +    YT   A+C+ C +C  + SP  FV H H        E   CHWGFDS+NW+ YL L  D
Sbjct:    1 GEKRLCYKELVEKILKGFSSQVINATRDRLQIFCPRCTPQQLEVLKLAGVLPWSCASAGLIAKSDAFRLIGALTGSNVPHRNSRL----------FSVDS-----LEVYHECFGGCVGTLEIELYTDPYAECVTCSQCDGVFSPRTFVTHHHTS-----GEVHTCHWGFDSANWKLYLMLCND 163
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skia (SKI proto-oncogene [Source:NCBI gene;Acc:101164645])

HSP 1 Score: 150.214 bits (378), Expect = 6.895e-38
Identity = 84/230 (36.52%), Postives = 123/230 (53.48%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G     ++         +   +D +     +V H+CFG+ KG++ P  Y   +A CI+CL+C  M     FV H+H     K  E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LDEIK++F
Sbjct:   72 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNTVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALIYGGAFPPRAKKELGGAGALELQLTDRS----FKVYHECFGKCKGLLVPELYGSPSAACIQCLDCRLMYPTHKFVVHSH-----KAQENRTCHWGFDSANWRAYILLSQDYT-GKEEKARLEQILDEIKEKF 290
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skia (SKI proto-oncogene [Source:NCBI gene;Acc:101164645])

HSP 1 Score: 150.214 bits (378), Expect = 7.159e-38
Identity = 84/230 (36.52%), Postives = 123/230 (53.48%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P+  +TE    T+L    I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI++++AER+       G     ++         +   +D +     +V H+CFG+ KG++ P  Y   +A CI+CL+C  M     FV H+H     K  E   CHWGFDS+NWR Y+ LS+D T  K E+  L   LDEIK++F
Sbjct:   72 PSDRSTER-CETVLEGETISCFVVGGEKRLCLPQILNTVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALIYGGAFPPRAKKELGGAGALELQLTDRS----FKVYHECFGKCKGLLVPELYGSPSAACIQCLDCRLMYPTHKFVVHSH-----KAQENRTCHWGFDSANWRAYILLSQDYT-GKEEKARLEQILDEIKEKF 290
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skib (ski oncogene [Source:NCBI gene;Acc:101171238])

HSP 1 Score: 149.828 bits (377), Expect = 8.344e-38
Identity = 92/268 (34.33%), Postives = 128/268 (47.76%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGI-------DINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF----------CTSVSELPPKRSIHTSTNSPS 1116
            P+  +TE    T+L +  I+ F   GEK LCLPQILN +L++  +  IN   + + I C+ C  ++L +L    ILP     CGLI+Q++AER+       G        D+ S E+                     +V H+CFG+ KG+  P  Y+   A CI+C++C  M  P  FV H+H+       E    HWGFDSSNWR Y+ L  D T  K E+  L   L E+K +F          C S S +P KR       SPS
Sbjct:   71 PSDRSTER-CETVLEREPISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVVGILPFSAPSCGLITQTDAERLCNALIYGGTYPPHCNKDLGSLELERTE--------------RSFKVYHECFGRCKGLFVPELYSSPAAACIQCMDCRLMFPPHKFVVHSHKRL-----ENRTVHWGFDSSNWRVYVLLDADYT-DKEEKSHLEQLLKELKGKFDPNGKLSSKACRSSSPIPTKRRKFDKLQSPS 317
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skila (SKI like proto-oncogene [Source:NCBI gene;Acc:111949033])

HSP 1 Score: 145.591 bits (366), Expect = 2.844e-36
Identity = 80/230 (34.78%), Postives = 121/230 (52.61%), Query Frame = 1 
Query:  367 PNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
            P  S+TE  T++LL    I+ F   GEK LCLPQ+LN +L++  +  IN   + + + C+ CD E+L +L    ILP     CGLI+ ++A+R+       G  +   + +   ++  +  TS        +V H C G  +G+  P  Y+   A CI+C+EC  + SP  FV H+H     K  +   CHWGFDS+ W  YL+L+     T  EE  L   LDE+K++F
Sbjct:  140 PCDSSTE-LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINTVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGA-VLPPDPSGKLSVLKESETS-------FQVEHQCLGMCQGLFAPQFYSQPEAPCIQCVECQLLFSPQTFVMHSH-----KSPDKRTCHWGFDSAKWPCYLQLARKYQGTA-EEPKLKLLLDEVKEKF 354
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skor1a (SKI family transcriptional corepressor 1 homolog-B-like [Source:NCBI gene;Acc:101169674])

HSP 1 Score: 101.679 bits (252), Expect = 4.710e-22
Identity = 69/246 (28.05%), Postives = 120/246 (48.78%), Query Frame = 1 
Query:  322 VNSTEELESDIRS-KSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRF 1053
             +S+  L+ D +   SP+S      + T L    I S   DG++ LCL QI N LLKN   ++I+    ++GI C +C   +L +L +   +P     CG+I++  AER+ K F                  +  K+  + A      V+H+C    +G   P +Y  + A+CI+C  CS   SP+ F+ H+H+   SK+ + +  ++    ++WR +L+L+E     K+  E +N   +++K  F
Sbjct:   15 ASSSPSLKQDAQGFSSPSSLKPNQVSETSLYGVPIVSLVIDGKERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLELLRRAGAMPISSRRCGMITKREAERLCKSFL--------------GAHSPPKLPENFA----FDVSHECAWGCRGSFIPARYNSSRAKCIKCTFCSMYFSPNKFIFHSHRTPESKYLQPDAANF----NSWRRHLKLTE-----KVPSEDINHAWEDVKAMF 233
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000067290.1 (SMESG000067290.1)

HSP 1 Score: 1053.12 bits (2722), Expect = 0.000e+0
Identity = 522/522 (100.00%), Postives = 522/522 (100.00%), Query Frame = 1 
Query:   55 MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLMRYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDIRSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKXXXXXXXXXXRQEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIECCDSSGENTLILDSPNTNTTIE 1620
            MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLMRYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDIRSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKLQLLNALFLLRQEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIECCDSSGENTLILDSPNTNTTIE
Sbjct:    1 MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLMRYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDIRSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTSTNSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKLQLLNALFLLRQEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIECCDSSGENTLILDSPNTNTTIE 522
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000044463.1 (SMESG000044463.1)

HSP 1 Score: 150.214 bits (378), Expect = 1.439e-40
Identity = 114/270 (42.22%), Postives = 151/270 (55.93%), Query Frame = 1 
Query:  799 FPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSV-----------SELPPKR-SIHTSTNSPSFSEVHFK------SLHLSGAVFQQCISKINNNTNLSSRDEKXXXXXXXXXXRQEHLQQINNLITERQQLIEGLMKKGPQK----------------SVEDNQTDQLLQIIKLKTAILKKEHNSRKRPASVNSDNVRDECQKKRVSSNINPSD 1506
             P   T+ +AQCIEC +C    SPS+FVGHTH   G + SE   CHWGF SSNWR YLRL+ED +RT  EE SLNDYL EIK RF   +            + P    S +TS + P+ + +          LH S ++FQQCI +I NN +L + D++ QL+N LF+LRQEH QQI+ LI+ERQ+LI+ L KK P                  + ++N +D  L  IK K AILK+  N+ KR  S   +N     +K+  S  INP +
Sbjct:    1 MPQLCTNNDAQCIECFDCGVWFSPSEFVGHTHNSGGLE-SEMSTCHWGFISSNWRLYLRLAEDPSRTTEEERSLNDYLTEIKNRFTQPIYDSLTIYNDHDQQTPSDNCSFNTSPSMPTPTSLSPTDGYNKIDLHNSSSMFQQCIMRICNN-HLENFDDRNQLINTLFMLRQEHHQQISTLISERQELIKAL-KKSPVANHSQWRTLELDEEKITTTQENSSDLTLLSIKDKIAILKRS-NAVKRKYSSGIENSDQRNEKE--SKTINPKE 264
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000018825.1 (SMESG000018825.1)

HSP 1 Score: 146.362 bits (368), Expect = 3.873e-37
Identity = 83/236 (35.17%), Postives = 127/236 (53.81%), Query Frame = 1 
Query:  403 LLNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSE-TEVCHWGFDSSNWRWYLRLSEDCTRTKLEEESLND------------YLDEIKKRFCTSVS 1068
            ++    IA FN  GE+ +CLPQ+L  +L   DI+ I++A+  + I C +C+ +++ +LH + I PK +  CGLI +S+AER+ K+              N N  T  +     +    I+V H CFG+Q+GI++P+ Y  ++A+CI+C  C       +FVGHTH     K  E +   HWGFDS+NWR  L++  D     +  E LND            Y DEIKKR  T+++
Sbjct:    1 MIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQP----------NQNYSTISETNQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTH-----KLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNV--EMLNDKKSILDKVKALYYEDEIKKRNQTNIN 219
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000070642.1 (SMESG000070642.1)

HSP 1 Score: 115.161 bits (287), Expect = 2.251e-27
Identity = 61/194 (31.44%), Postives = 101/194 (52.06%), Query Frame = 1 
Query:  400 TLLNKTYIASFNNDGEKLLCLPQIL-NLLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSNWRWYLRL 978
            T L   ++ SF N     + +P ++ +  ++ID   IN+ +  + I C +C  E+L +LH   IL   V  CGLI + +A+R+ KF              +N  +TS + TS       I + H CFG+Q+  ++P  Y  +N++CI+C  CS++ +  +FV HTH     K +     HWGF S NWR+++ +
Sbjct:    9 TELENHFLISFANGSNIKILMPHLIRSFFQDIDYPTINQLLTFLSIKCCQCTPEQLRILHTTKILSSDVNQCGLIDKVDAKRLCKFI-------------HNTNLTSIRSTSSLFV---IPIIHYCFGRQQAFLYPDLYVKSNSRCIKCASCSQIFTTCEFVKHTHL----KINHINTVHWGFHSLNWRYFIYI 182
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000073656.1 (SMESG000073656.1)

HSP 1 Score: 84.3445 bits (207), Expect = 3.133e-17
Identity = 61/221 (27.60%), Postives = 107/221 (48.42%), Query Frame = 1 
Query:  349 DIRSKSPNSSTTENFTYTL----LNKTYIASFNNDGEKLLCLPQILN-LLKNIDISDINEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKFFTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFPLKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSSN---WRWYLRLSED 987
            D +S+  NS+   NF+ T+    L  + I S   +G++ LCL QI N LL     ++I+    ++GI C +C   +L  L +   +P     CG+I++  AER++K F               + I+  K+ S+ A      V H C     G   P +Y  + A+CI+C +C    SP+ F+ H H+    +  ++ + +   D++N   WR +L +S++
Sbjct:    2 DNQSEVDNSNPIHNFSNTIKMVSLYGSSIVSLIINGQERLCLAQISNTLLSKYSYNEIHNRRVALGITCVQCTPVQLDQLRRAGAMPISSRRCGMITKREAERLVKSFL--------------DEISPPKLPSNFA----FNVKHSCGWGCYGSFIPTRYNSSRAKCIKCYQCQIFFSPNKFIFHCHKPDNDEIKKSNLNYHHPDAANFNAWRRHLVISDE 204
The following BLAST results are available for this feature:
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SKI1.187e-3934.83SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10... [more]
SKIL1.203e-3333.33SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
SKIL1.403e-3333.33SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
SKIL1.721e-3333.33SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
SKIL1.721e-3333.33SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Snoo1.020e-3236.55gene:FBgn0085450 transcript:FBtr0343409[more]
Snoo1.020e-3236.55gene:FBgn0085450 transcript:FBtr0112717[more]
Snoo1.020e-3236.55gene:FBgn0085450 transcript:FBtr0112719[more]
Snoo1.020e-3236.55gene:FBgn0085450 transcript:FBtr0112718[more]
fuss3.517e-1727.36gene:FBgn0039932 transcript:FBtr0301336[more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
skila6.976e-4136.09SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GEN... [more]
skila9.582e-4136.09SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GEN... [more]
skila3.691e-4034.05SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GEN... [more]
skib7.859e-3934.62v-ski avian sarcoma viral oncogene homolog b [Sour... [more]
skia9.054e-3836.96v-ski avian sarcoma viral oncogene homolog a [Sour... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SKI6.790e-3734.48SKI proto-oncogene [Source:NCBI gene;Acc:100486949... [more]
ENSXETT00000042147.12.084e-3334.63SKI-like proto-oncogene [Source:NCBI gene;Acc:1004... [more]
arg11.610e-2029.44arginase 1 [Source:Xenbase;Acc:XB-GENE-966913][more]
SKOR17.586e-1928.06SKI family transcriptional corepressor 1 [Source:N... [more]
SKOR18.475e-1928.06SKI family transcriptional corepressor 1 [Source:N... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ski1.505e-3935.58ski sarcoma viral oncogene homolog (avian) [Source... [more]
Ski1.208e-3836.14ski sarcoma viral oncogene homolog (avian) [Source... [more]
Skil3.748e-3532.42SKI-like [Source:MGI Symbol;Acc:MGI:106203][more]
Skil6.165e-3532.42SKI-like [Source:MGI Symbol;Acc:MGI:106203][more]
Skil1.190e-3432.42SKI-like [Source:MGI Symbol;Acc:MGI:106203][more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P17863|SKI_AVIES2.053e-3937.39Transforming protein Ski OS=Avian erythroblastosis... [more]
sp|P12755|SKI_HUMAN5.701e-3934.83Ski oncogene OS=Homo sapiens OX=9606 GN=SKI PE=1 S... [more]
sp|Q60698|SKI_MOUSE8.546e-3935.58Ski oncogene OS=Mus musculus OX=10090 GN=Ski PE=1 ... [more]
sp|P49140|SKI_CHICK2.007e-3837.39Ski oncogene OS=Gallus gallus OX=9031 GN=SKI PE=1 ... [more]
sp|Q9TUG2|SKI_HORSE9.109e-3834.62Ski oncogene OS=Equus caballus OX=9796 GN=SKI PE=2... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S6KMI80.000e+0100.00c-SKI_SMAD_bind domain-containing protein OS=Schmi... [more]
A0A158QGJ71.937e-4141.75c-SKI_SMAD_bind domain-containing protein OS=Roden... [more]
A0A564YIK66.754e-4142.23c-SKI_SMAD_bind domain-containing protein OS=Hymen... [more]
A0A564YIS26.942e-4142.23c-SKI_SMAD_bind domain-containing protein OS=Hymen... [more]
A0A0R3SIW87.124e-4142.23c-SKI_SMAD_bind domain-containing protein OS=Hymen... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
skila2.819e-3635.65SKI like proto-oncogene [Source:NCBI gene;Acc:1030... [more]
skib3.202e-3533.61ski oncogene-like [Source:NCBI gene;Acc:103031474][more]
skia1.745e-3435.65ski oncogene [Source:NCBI gene;Acc:103046211][more]
skib3.187e-3434.25ski oncogene-like [Source:NCBI gene;Acc:103031474][more]
skilb2.127e-2829.57ski-like protein [Source:NCBI gene;Acc:103027845][more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000001301.12.154e-2027.40pep scaffold:Pmarinus_7.0:GL481803:9978:11426:-1 g... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO418362.356e-2432.24Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
skia6.895e-3836.52SKI proto-oncogene [Source:NCBI gene;Acc:101164645... [more]
skia7.159e-3836.52SKI proto-oncogene [Source:NCBI gene;Acc:101164645... [more]
skib8.344e-3834.33ski oncogene [Source:NCBI gene;Acc:101171238][more]
skila2.844e-3634.78SKI like proto-oncogene [Source:NCBI gene;Acc:1119... [more]
skor1a4.710e-2228.05SKI family transcriptional corepressor 1 homolog-B... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000067290.10.000e+0100.00SMESG000067290.1[more]
SMESG000044463.11.439e-4042.22SMESG000044463.1[more]
SMESG000018825.13.873e-3735.17SMESG000018825.1[more]
SMESG000070642.12.251e-2731.44SMESG000070642.1[more]
SMESG000073656.13.133e-1727.60SMESG000073656.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003733 ID=SMED30003733|Name=c-SKI_SMAD_bind domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1799bp
AAAAATAATTTGTCTTACAGCAGTAAAAATAACCATAATTAATTACTCAT
TGAAATGCTTTTGAAACCTGAACCATTGAAGGGATTGGACTGGTTGAGTC
CGATAAGTGGTTATGATAGGGAGATGATTAAAAATTTCCAGCAGTTGTAT
TCACAGAAATTGTTAGCAGCTAAAAAGTCAATTTTCCCAACGACTATGCT
GATGAGATATCTGTATGGTTGTCCGACGAGTGGGAACCTATCTGCTGATA
TTGGCAGCAAAACCAGTCCATTTAGACCATATCAAAAACCGGAGATCGAC
AATGTCAAAACCAACGACACAGTGAACAGCACAGAGGAACTCGAATCCGA
TATCCGATCAAAATCCCCGAACAGTTCAACAACGGAAAATTTCACCTATA
CCTTGCTCAACAAAACCTACATTGCAAGTTTCAACAACGACGGAGAGAAA
TTACTTTGTTTACCACAGATTTTGAATTTATTAAAAAATATCGACATAAG
TGACATTAATGAAGCCATCAATTCAATGGGAATCATCTGTACTGAGTGCG
ATGAAGAGAGATTGAGTGTACTACATAAGCATAATATTCTCCCGAAACAA
GTCACATGCTGTGGTTTGATTTCTCAGTCCAATGCAGAAAGGATGCTTAA
ATTTTTCACAAGTATCGGAATTGATATCAACTCAAGCGAAATGAATAACA
ATAATACAATTACATCGGACAAAATCACTTCGGACTCGGCAGCATATCAT
CAAATCCGGGTCACTCATGACTGTTTCGGACAACAGAAAGGCATCATCTT
CCCTCTAAAGTATACTCACGCCAATGCTCAATGCATCGAGTGTCTAGAAT
GCAGTAAGATGATGTCACCGTCAGATTTCGTCGGTCATACCCATCAGGAA
TTCGGATCGAAATGGTCAGAAACTGAAGTTTGTCATTGGGGTTTCGATTC
AAGCAACTGGCGTTGGTATTTGAGGTTGAGCGAAGACTGTACTAGGACGA
AATTGGAGGAAGAAAGCTTGAATGATTATCTAGATGAAATTAAAAAACGA
TTTTGTACAAGTGTCAGTGAGTTGCCTCCGAAAAGATCAATTCACACATC
AACCAATTCTCCGTCGTTTTCTGAAGTTCACTTTAAAAGTTTGCATTTAT
CGGGAGCTGTATTCCAGCAATGTATTTCGAAAATCAACAACAATACCAAT
CTTTCGAGTCGGGACGAAAAACTCCAGCTATTGAATGCGTTGTTCCTCTT
GCGTCAGGAGCACTTGCAACAGATCAACAATCTGATCACAGAACGACAAC
AATTGATTGAAGGTCTCATGAAAAAAGGCCCCCAAAAATCTGTCGAAGAC
AACCAAACCGACCAACTGCTACAAATCATCAAATTGAAAACTGCAATTCT
GAAGAAGGAACACAATAGTCGCAAAAGACCCGCGTCTGTCAACTCAGACA
ATGTTAGAGATGAATGTCAAAAGAAAAGAGTTTCCAGCAACATCAATCCG
AGTGATGAAGTGCAACCGAAAAAGACTCTCGTCAATTCTCCGCTCACTAT
AGAATGCTGCGATTCAAGCGGGGAAAACACATTGATACTCGACTCCCCTA
ACACGAATACGACTATAGAATAGCCGGGACTATTTATTATAGGAAATCAT
TTTCAGTTTTCATTGTTTTTTAATCCGATTGTTTTATTAGGCGTGCATTT
GATGTAGAATTCATATCAAAGTTTTCCTGTTTGACCATTTTCATGTATTA
ATTATTTTTTTCTGATGGCAATGTTTTGATGGTAAACACTTTTATTTAT
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protein sequence of SMED30003733-orf-1

>SMED30003733-orf-1 ID=SMED30003733-orf-1|Name=SMED30003733-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=523bp
MLLKPEPLKGLDWLSPISGYDREMIKNFQQLYSQKLLAAKKSIFPTTMLM
RYLYGCPTSGNLSADIGSKTSPFRPYQKPEIDNVKTNDTVNSTEELESDI
RSKSPNSSTTENFTYTLLNKTYIASFNNDGEKLLCLPQILNLLKNIDISD
INEAINSMGIICTECDEERLSVLHKHNILPKQVTCCGLISQSNAERMLKF
FTSIGIDINSSEMNNNNTITSDKITSDSAAYHQIRVTHDCFGQQKGIIFP
LKYTHANAQCIECLECSKMMSPSDFVGHTHQEFGSKWSETEVCHWGFDSS
NWRWYLRLSEDCTRTKLEEESLNDYLDEIKKRFCTSVSELPPKRSIHTST
NSPSFSEVHFKSLHLSGAVFQQCISKINNNTNLSSRDEKLQLLNALFLLR
QEHLQQINNLITERQQLIEGLMKKGPQKSVEDNQTDQLLQIIKLKTAILK
KEHNSRKRPASVNSDNVRDECQKKRVSSNINPSDEVQPKKTLVNSPLTIE
CCDSSGENTLILDSPNTNTTIE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR037000Ski_DNA-bd_sf
IPR023216Tscrpt_reg_SKI_SnoN
IPR014890c-SKI_SMAD4-bd_dom
IPR010919SAND-like_dom_sf
IPR003380SKI/SNO/DAC
IPR009061DNA-bd_dom_put_sf
Vocabulary: molecular function
TermDefinition
GO:0046332SMAD binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR014890c-SKI SMAD4-binding domainSMARTSM01046c_SKI_SMAD_bind_2coord: 233..334
e-value: 2.5E-22
score: 90.2
IPR014890c-SKI SMAD4-binding domainPFAMPF08782c-SKI_SMAD_bindcoord: 234..333
e-value: 6.0E-27
score: 93.7
IPR010919SAND-like domain superfamilyGENE3DG3DSA:3.10.390.10coord: 234..339
e-value: 4.6E-32
score: 112.2
IPR010919SAND-like domain superfamilySUPERFAMILYSSF63763SAND domain-likecoord: 234..317
IPR003380SKI/SNO/DAC domainPFAMPF02437Ski_Snocoord: 108..202
e-value: 3.3E-24
score: 84.7
IPR037000Ski-like, DNA-binding domain superfamilyGENE3DG3DSA:3.10.260.20coord: 101..203
e-value: 4.4E-26
score: 92.8
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 452..487
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 452..475
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 82..107
NoneNo IPR availablePANTHERPTHR10005:SF25SNO ONCOGENE, ISOFORM Bcoord: 113..453
IPR023216Transcription regulator SKI/SnoNPANTHERPTHR10005SKI ONCOGENE-RELATEDcoord: 113..453
IPR009061Putative DNA-binding domain superfamilySUPERFAMILYSSF46955Putative DNA-binding domaincoord: 107..201