NCOA5

Overview


Name	NCOA5 (AHA14850.1)
Smed ID	SMED30003730
Length (bp)	4514

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of NCOA5 (SMED30003730) t-SNE clustered cells

Violin plots show distribution of expression levels for NCOA5 (SMED30003730) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NCOA5 (SMED30003730) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NCOA5 (SMED30003730) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30003730

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30003730	h1SMcG0003708	SmedASXL_011892	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30003730	h1SMcG0003708	SmedASXL_011892	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30003730	h1SMcG0003708	dd_Smed_v4_2395_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30003730	h1SMcG0003708	OX_Smed_1.0.03792	ox_Smed_v2	PMID:24238224 Kao et al., 2013

Note: Hover over icons to view figure legend

Homology

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BLAST of NCOA5 vs. Ensembl Human
Match: NCOA5 (nuclear receptor coactivator 5 [Source:HGNC Symbol;Acc:HGNC:15909])

HSP 1 Score: 57.7658 bits (138), Expect = 1.417e-7
Identity = 46/167 (27.54%), Postives = 77/167 (46.11%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVR---------------DLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVI-----------QHQTQLHSKILNIL 3400
            EHRNMP  +A+  VARN+ERY+   R               D   +  +    P     G   P   I   ++LLAD+R LT EE +++I+++++R + L  +       PI+  P  +   S A   + P +QP++  +V+             Q +L +KIL++ 
Sbjct:  277 EHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPP--AIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGAT--SGASLKTQPSSQPLQSGQVLPSATPTPSAPPTSQQELQAKILSLF 439

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BLAST of NCOA5 vs. Ensembl Xenopus
Match: ncoa5 (nuclear receptor coactivator 5 [Source:NCBI gene;Acc:394533])

HSP 1 Score: 63.5438 bits (153), Expect = 2.536e-9
Identity = 56/198 (28.28%), Postives = 90/198 (45.45%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVR-----DLKTIAPKPTFDPSRMPPGFIAPD-------DKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASA----------EETMEKAPITGLPNESVQNSMAPKL----SIPGNQPVREEKVIQHQTQLHSKILNIL-----------KPVPHQSASGVVDNE-INNM 3457
            EHRNMPL +A+  +ARN+ER++   R     D+   A K + D        +A +         I   L LLAD+R +T+EE+++VI +++ + + L  A            +M  AP++ L N++   +  P L    +I    P   + V   Q +L +KIL++             P     ASG V N+   NM
Sbjct:  297 EHRNMPLADAMVLIARNYERFKSETREKEREDIARQAAKMSADAILRERALLAEEVVRGPAPPGIQAVLGLLADNRYVTVEEIDKVIHYLRDKKERLLGAPSDSLPSQLSRPSMGAAPVSSLDNQTSGLANNPALQMTQTISSASPA-GQSVNTSQQELQAKILSLFNSGSAVGASSNSPASSTPASGSVSNQSFGNM 493

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BLAST of NCOA5 vs. Ensembl Xenopus
Match: ncoa5 (nuclear receptor coactivator 5 [Source:NCBI gene;Acc:394533])

HSP 1 Score: 63.1586 bits (152), Expect = 2.708e-9
Identity = 56/198 (28.28%), Postives = 90/198 (45.45%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVR-----DLKTIAPKPTFDPSRMPPGFIAPD-------DKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASA----------EETMEKAPITGLPNESVQNSMAPKL----SIPGNQPVREEKVIQHQTQLHSKILNIL-----------KPVPHQSASGVVDNE-INNM 3457
            EHRNMPL +A+  +ARN+ER++   R     D+   A K + D        +A +         I   L LLAD+R +T+EE+++VI +++ + + L  A            +M  AP++ L N++   +  P L    +I    P   + V   Q +L +KIL++             P     ASG V N+   NM
Sbjct:  287 EHRNMPLADAMVLIARNYERFKSETREKEREDIARQAAKMSADAILRERALLAEEVVRGPAPPGIQAVLGLLADNRYVTVEEIDKVIHYLRDKKERLLGAPSDSLPSQLSRPSMGAAPVSSLDNQTSGLANNPALQMTQTISSASPA-GQSVNTSQQELQAKILSLFNSGSAVGASSNSPASSTPASGSVSNQSFGNM 483

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BLAST of NCOA5 vs. Ensembl Xenopus
Match: ENSXETT00000043220.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:7:36411169:36451375:1 gene:ENSXETG00000018966.1 transcript:ENSXETT00000043220.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.151 bits (139), Expect = 1.000e-7
Identity = 31/61 (50.82%), Postives = 39/61 (63.93%), Query Frame = 3

Query:  240 PQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            P  +   I    L   +PNI    RI LT  ++VA+ +RSFSKLK+IK YLRS+M QERLS
Sbjct:  628 PLDLCQMIQDYSLADCYPNIDTAFRIFLTSPVTVASCKRSFSKLKLIKNYLRSSMEQERLS 688

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BLAST of NCOA5 vs. Ensembl Mouse
Match: Ncoa5 (nuclear receptor coactivator 5 [Source:MGI Symbol;Acc:MGI:2385165])

HSP 1 Score: 55.0694 bits (131), Expect = 6.445e-7
Identity = 47/172 (27.33%), Postives = 77/172 (44.77%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVR-----DLKTIAPKPTFDP---------------SRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVI-----------QHQTQLHSKILNIL 3400
            EHRNMP  +A+  VARN+ERY+   R     ++   A K   D                   PP        I   ++LLAD+R LT EE +++I+++++R + L  +       PI+  P  +   S     S P +QP++  +V+             Q +L +KIL++ 
Sbjct:  277 EHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAILQERDRGGPEEGGRGGHPPA-------IQSLINLLADNRYLTAEETDKIINYLRERKERLLRSSADSLPGPISRQPLGAASGSSLK--SQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLF 439

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BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|Q9HCD5|NCOA5_HUMAN (Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2)

HSP 1 Score: 57.7658 bits (138), Expect = 6.806e-7
Identity = 46/167 (27.54%), Postives = 77/167 (46.11%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVR---------------DLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVI-----------QHQTQLHSKILNIL 3400
            EHRNMP  +A+  VARN+ERY+   R               D   +  +    P     G   P   I   ++LLAD+R LT EE +++I+++++R + L  +       PI+  P  +   S A   + P +QP++  +V+             Q +L +KIL++ 
Sbjct:  277 EHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPP--AIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGAT--SGASLKTQPSSQPLQSGQVLPSATPTPSAPPTSQQELQAKILSLF 439

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BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|Q91W39|NCOA5_MOUSE (Nuclear receptor coactivator 5 OS=Mus musculus OX=10090 GN=Ncoa5 PE=1 SV=1)

HSP 1 Score: 55.0694 bits (131), Expect = 4.508e-6
Identity = 47/172 (27.33%), Postives = 77/172 (44.77%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVR-----DLKTIAPKPTFDP---------------SRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVI-----------QHQTQLHSKILNIL 3400
            EHRNMP  +A+  VARN+ERY+   R     ++   A K   D                   PP        I   ++LLAD+R LT EE +++I+++++R + L  +       PI+  P  +   S     S P +QP++  +V+             Q +L +KIL++ 
Sbjct:  277 EHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAILQERDRGGPEEGGRGGHPPA-------IQSLINLLADNRYLTAEETDKIINYLRERKERLLRSSADSLPGPISRQPLGAASGSSLK--SQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLF 439

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BLAST of NCOA5 vs. TrEMBL
Match: U6A492 (NCOA5 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 558.14 bits (1437), Expect = 3.408e-180
Identity = 272/272 (100.00%), Postives = 272/272 (100.00%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPI 3793
            EHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPI
Sbjct:  258 EHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPI 529

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BLAST of NCOA5 vs. TrEMBL
Match: A0A5N4AZG8 (Uncharacterized protein OS=Photinus pyralis OX=7054 GN=PPYR_04869 PE=4 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 3.132e-17
Identity = 49/108 (45.37%), Postives = 72/108 (66.67%), Query Frame = 3

Query:  105 LDLCIIIKVKWKKLTGEQRNESHINGIEFFEEIKTIKVFL--KEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            L+ C  +++K    T E  +   IN I+ + EI T+ +++  K  +  + +L Y+++NDLQ  FPN+F+  RI LT+ ++VA  ERSFSKLK+IKTYLRSTM Q RLS
Sbjct:  123 LEYCKNLEMKLTDPTTENMD---INAIDLYNEIDTLSIYINNKNSMSAKEVLTYLVKNDLQCIFPNLFVALRIFLTMPVTVAHGERSFSKLKLIKTYLRSTMSQLRLS 227

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BLAST of NCOA5 vs. TrEMBL
Match: A0A1Y1KMA7 (Dimer_Tnp_hAT domain-containing protein (Fragment) OS=Photinus pyralis OX=7054 PE=4 SV=1)

HSP 1 Score: 87.4261 bits (215), Expect = 1.744e-16
Identity = 49/92 (53.26%), Postives = 65/92 (70.65%), Query Frame = 3

Query:  162 NESHINGIEFFEEIKTIKVFL--KEDIK--PQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLSQ 425
             ES I+  E  EE++++K+F+  ++ IK  P  IL YI +N L  +FPN+ I  RILLTL +SVA+ ERSFSKLK+IK +LRSTM Q RLS 
Sbjct:    4 GESDIDSQELCEELESLKLFVTGQQTIKCEPLEILNYICENSLSGSFPNVTIGLRILLTLPVSVASAERSFSKLKLIKNFLRSTMSQNRLSH 95

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BLAST of NCOA5 vs. TrEMBL
Match: J9L841 (Dimer_Tnp_hAT domain-containing protein OS=Acyrthosiphon pisum OX=7029 PE=4 SV=2)

HSP 1 Score: 87.4261 bits (215), Expect = 1.504e-15
Identity = 43/84 (51.19%), Postives = 60/84 (71.43%), Query Frame = 3

Query:  168 SHINGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERL 419
            S IN +E  EEI T++  LK +  P++IL +I +N L   FPN+++  RILLTL ++ A+ ERSFSKLKI+K YLRS + Q+RL
Sbjct:   82 SDINSVELCEEINTLQRHLKNENDPKAILQFICENKLIELFPNVYVALRILLTLPVTAASAERSFSKLKIVKNYLRSQISQDRL 165

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BLAST of NCOA5 vs. TrEMBL
Match: N6UEN3 (Uncharacterized protein (Fragment) OS=Dendroctonus ponderosae OX=77166 GN=YQE_03356 PE=4 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 2.298e-15
Identity = 48/92 (52.17%), Postives = 64/92 (69.57%), Query Frame = 3

Query:  144 LTGEQRNESHINGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERL 419
            L+   RNE  ING+E  +E++ +  F +  +  +  L YI++N+L  +FPN+ I  RILLT+ ISVAT +RS SKLKIIK YLRSTM QERL
Sbjct:  396 LSDNNRNEKDINGVELLQEVQFLHRFNQSGLSLEQALNYIIENNLTHSFPNVTIAIRILLTIPISVATAKRSCSKLKIIKDYLRSTMSQERL 487

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BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000036272.1 (pep primary_assembly:Astyanax_mexicanus-2.0:20:11935414:11938921:1 gene:ENSAMXG00000041670.1 transcript:ENSAMXT00000036272.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 85.8853 bits (211), Expect = 2.486e-16
Identity = 49/99 (49.49%), Postives = 65/99 (65.66%), Query Frame = 3

Query:  138 KKLTGEQRNESHINGIEFFEEIKTIKVFLKEDIKPQS----ILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            KKLT   + E+ I+G E  +EI  +       + PQ+    +L Y+  N LQ  +PN++I  RI LTL ++VA+ ERSFSKLK+IKTYLRSTM QERLS
Sbjct:  696 KKLT--DKGEADIDGQEMMQEIINLP-----QLSPQTTAFELLTYLHDNSLQEVYPNLWIALRIALTLPVTVASAERSFSKLKLIKTYLRSTMGQERLS 787

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BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000055782.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001476.1:1798:4262:-1 gene:ENSAMXG00000042376.1 transcript:ENSAMXT00000055782.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 67.3958 bits (163), Expect = 8.823e-11
Identity = 37/77 (48.05%), Postives = 48/77 (62.34%), Query Frame = 3

Query:  192 FEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
             E    + VF      P  IL YI + +L   + N+ I  R+LLTL I+VA+ ERSFS LK+IK +LRSTM QERL+
Sbjct:  634 LEVTAAVSVFPDHISSPADILDYIYKENLLELYGNLSIALRLLLTLPITVASGERSFSSLKLIKNFLRSTMSQERLT 710

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BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000025204.2 (pep primary_assembly:Astyanax_mexicanus-2.0:12:7364240:7371214:-1 gene:ENSAMXG00000024490.2 transcript:ENSAMXT00000025204.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.1586 bits (152), Expect = 1.768e-9
Identity = 33/61 (54.10%), Postives = 42/61 (68.85%), Query Frame = 3

Query:  240 PQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            P  +L YI    L   +  + I  R+LLTL +SVA+ ERSFS LK+IKTY+RSTM QERL+
Sbjct:  639 PFDMLNYIYSEKLLDLYSTLSIALRLLLTLPVSVASGERSFSALKLIKTYMRSTMGQERLT 699

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BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000033195.1 (pep primary_assembly:Astyanax_mexicanus-2.0:16:11277158:11279506:-1 gene:ENSAMXG00000030798.1 transcript:ENSAMXT00000033195.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.077 bits (144), Expect = 1.611e-8
Identity = 31/58 (53.45%), Postives = 40/58 (68.97%), Query Frame = 3

Query:  249 ILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            +L  I +  LQ+ F  I I  RI  TL I+VA  ER+FSKLK++K YLRSTM Q+RL+
Sbjct:  688 LLNAIWEMQLQSIFGEICIALRIFCTLPITVAGGERAFSKLKLVKNYLRSTMGQDRLN 745

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BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000042715.1 (pep primary_assembly:Astyanax_mexicanus-2.0:16:11855083:11857132:-1 gene:ENSAMXG00000035113.1 transcript:ENSAMXT00000042715.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 2.055e-7
Identity = 33/77 (42.86%), Postives = 47/77 (61.04%), Query Frame = 3

Query:  195 EEIKTIKVFLKEDIK-PQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            +E+   K F+ E  K P  +L  ++  +LQ+TFPN++I  R+ LT+ I+    ERSFSKL  IK  LR  M Q RL+
Sbjct:  548 DELIQYKSFITEKEKHPSKMLKTMINLNLQSTFPNVYIALRLFLTVPITNCEGERSFSKLARIKNELRIRMRQNRLN 624

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BLAST of NCOA5 vs. Ensembl Nematostella
Match: EDO40596 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6Q7])

HSP 1 Score: 53.1434 bits (126), Expect = 7.075e-8
Identity = 29/76 (38.16%), Postives = 50/76 (65.79%), Query Frame = 3

Query:  198 EIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLSQ 425
            +++ +   ++E+  P+S +   L+N     +PN+ ++ RIL TL+++ A +ERSFS +K +KTYLR+TM  ER S 
Sbjct:   49 DVELVHWRIEEESIPRSAV-NALKNCDAEFYPNVHVLLRILCTLSVTSAESERSFSTMKRLKTYLRNTMSTERESS 123

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BLAST of NCOA5 vs. Ensembl Nematostella
Match: EDO35148 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMD4])

HSP 1 Score: 50.447 bits (119), Expect = 2.624e-7
Identity = 26/53 (49.06%), Postives = 39/53 (73.58%), Query Frame = 3

Query:  264 LQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            L+N  +  + NI+ + +IL+TL IS A+ ERS S L+ +KTYLRSTM ++RL+
Sbjct:   40 LENIDKDAYVNIYFMLKILITLPISSASCERSISSLRNLKTYLRSTMTEDRLN 92

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BLAST of NCOA5 vs. Ensembl Nematostella
Match: EDO32247 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVL6])

HSP 1 Score: 50.447 bits (119), Expect = 2.754e-7
Identity = 25/48 (52.08%), Postives = 36/48 (75.00%), Query Frame = 3

Query:  279 QATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            +  F NI+ + +IL+TL IS A+ ERS S L+ +KTYLRSTM ++RL+
Sbjct:   45 KDAFVNIYFMLKILITLPISSASCERSISSLRNLKTYLRSTMTEDRLN 92

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BLAST of NCOA5 vs. Ensembl Nematostella
Match: EDO26036 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TD20])

HSP 1 Score: 49.6766 bits (117), Expect = 3.826e-7
Identity = 24/45 (53.33%), Postives = 35/45 (77.78%), Query Frame = 3

Query:  288 FPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            + NI+ + +IL+TL IS A+ ERS S L+ +KTYLRSTM ++RL+
Sbjct:   47 YVNIYFMLKILITLPISSASCERSISSLQNLKTYLRSTMTEDRLN 91

[Close]

BLAST of NCOA5 vs. Ensembl Nematostella
Match: EDO33687 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRH2])

HSP 1 Score: 49.6766 bits (117), Expect = 5.594e-7
Identity = 25/49 (51.02%), Postives = 36/49 (73.47%), Query Frame = 3

Query:  276 LQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            L   + NI+ + +IL+TL IS A+ ERS S L+ +KTYLRSTM ++RL+
Sbjct:   42 LTDAYVNIYFMLKILITLPISSASCERSISSLRNLKTYLRSTMTEDRLN 90

[Close]

BLAST of NCOA5 vs. Ensembl Medaka
Match: ENSORLT00000028133.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:111948955])

HSP 1 Score: 66.2402 bits (160), Expect = 2.483e-10
Identity = 35/83 (42.17%), Postives = 50/83 (60.24%), Query Frame = 3

Query:  174 INGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            ++  E  +EIK +            ++ ++   DL   +PN +   RI LTL ++VA  ERSFSKLK+IK+YLRSTM QERL+
Sbjct:  735 LDSRELVQEIKNLPNLPSTTPSLLELISFMSDKDLSEIYPNFWTALRIALTLPVTVAQAERSFSKLKLIKSYLRSTMSQERLT 817

[Close]

BLAST of NCOA5 vs. Ensembl Medaka
Match: ENSORLT00000042294.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:110016639])

HSP 1 Score: 66.2402 bits (160), Expect = 2.483e-10
Identity = 35/83 (42.17%), Postives = 50/83 (60.24%), Query Frame = 3

Query:  174 INGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            ++  E  +EIK +            ++ ++   DL   +PN +   RI LTL ++VA  ERSFSKLK+IK+YLRSTM QERL+
Sbjct:  735 LDSRELVQEIKNLPNLPSTTPSLLELISFMSDKDLSEIYPNFWTALRIALTLPVTVAQAERSFSKLKLIKSYLRSTMSQERLT 817

[Close]

BLAST of NCOA5 vs. Ensembl Medaka
Match: ENSORLT00000045044.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:111948193])

HSP 1 Score: 66.2402 bits (160), Expect = 2.483e-10
Identity = 35/83 (42.17%), Postives = 50/83 (60.24%), Query Frame = 3

Query:  174 INGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            ++  E  +EIK +            ++ ++   DL   +PN +   RI LTL ++VA  ERSFSKLK+IK+YLRSTM QERL+
Sbjct:  735 LDSRELVQEIKNLPNLPSTTPSLLELISFMSDKDLSEIYPNFWTALRIALTLPVTVAQAERSFSKLKLIKSYLRSTMSQERLT 817

[Close]

BLAST of NCOA5 vs. Planmine SMEST
Match: SMESG000010804.1 (SMESG000010804.1)

HSP 1 Score: 559.296 bits (1440), Expect = 0.000e+0
Identity = 272/272 (100.00%), Postives = 272/272 (100.00%), Query Frame = 2

Query: 2978 EHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPI 3793
            EHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPI
Sbjct:  307 EHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPGFIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKAPITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVPHQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQSQFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQRPMAQGPGGQPFGNSFHGYYQPPIGQPI 578

[Close]

BLAST of NCOA5 vs. Planmine SMEST
Match: SMESG000078916.1 (SMESG000078916.1)

HSP 1 Score: 88.1965 bits (217), Expect = 6.237e-20
Identity = 51/130 (39.23%), Postives = 77/130 (59.23%), Query Frame = 3

Query:  129 VKWKKLTGEQRNESHINGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLSQ----GFPNCVPRSLN-----RYFTKIWSKFR 491
            +K+ ++     N+  I GI+  EE+  I   LK    P  +L YILQN+L   +PN++   +ILLT+ +SVA+ ERSFS+LK+IK YLRS++ Q RLS        N + R+++     R FT I ++ R
Sbjct:   20 LKYLEVILSDGNQKDIEGIQLSEELVFISNLLKPSDDPNDVLKYILQNELIPIYPNLYFALKILLTMPVSVASGERSFSRLKLIKNYLRSSLTQNRLSGPSILSMENDIARAIDKEDILRDFTNIKARRR 149

[Close]

BLAST of NCOA5 vs. Planmine SMEST
Match: SMESG000077250.1 (SMESG000077250.1)

HSP 1 Score: 86.2705 bits (212), Expect = 2.840e-19
Identity = 51/119 (42.86%), Postives = 73/119 (61.34%), Query Frame = 3

Query:  162 NESHINGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLSQ----GFPNCVPRSLN-----RYFTKIWSKFR 491
            N+  I GI   EE+  I  FLK    P  +L YILQN+L   +PN++I  +ILLT+ ++VA+ ERSFS LK+IK YLRS+M Q RLS+       N + R+++     R FT + ++ R
Sbjct:   21 NQKDIEGI-LSEELGFISNFLKPSDDPNDVLKYILQNELIPIYPNLYIALKILLTMPVNVASGERSFSLLKLIKNYLRSSMTQNRLSELSILSIKNDIARAIDKEDILRDFTNLKARKR 138

[Close]

BLAST of NCOA5 vs. Planmine SMEST
Match: SMESG000026726.1 (SMESG000026726.1)

HSP 1 Score: 86.2705 bits (212), Expect = 9.793e-19
Identity = 46/104 (44.23%), Postives = 66/104 (63.46%), Query Frame = 3

Query:  162 NESHINGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLSQ----GFPNCVPRSLNR 461
            N+  I  I+  EE+  I   LK    P  +L YILQN+L   +PN++I  +ILLT+ +SVA+ ERSFS+LK+IK YLRS+M Q RLS        N + R++++
Sbjct:   70 NQKDIEVIQLSEELVFISNLLKSSDDPNDVLKYILQNELIPIYPNLYIALKILLTMPVSVASGERSFSRLKLIKDYLRSSMTQNRLSGLSILSIENNIARAIDK 173

[Close]

BLAST of NCOA5 vs. Planmine SMEST
Match: SMESG000036749.1 (SMESG000036749.1)

HSP 1 Score: 83.5741 bits (205), Expect = 1.577e-16
Identity = 36/83 (43.37%), Postives = 65/83 (78.31%), Query Frame = 3

Query:  174 INGIEFFEEIKTIKVFLKEDIKPQSILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLRSTMLQERLS 422
            I+G+E ++E+ ++K+ +K+  +P+ ++ ++ + +L+ +FPN+    ++LLT+ +SVA+ ERSFSKLKIIK +LR++M QERLS
Sbjct:  653 ISGVELYQELVSLKIIIKDRKQPEELIKFLYKYNLETSFPNVATSLKLLLTVPVSVASGERSFSKLKIIKNHLRTSMTQERLS 735

HSP 2 Score: 23.483 bits (49), Expect = 1.577e-16
Identity = 9/17 (52.94%), Postives = 11/17 (64.71%), Query Frame = 2

Query:   68 TRFEVLKLYNDIFGFMY 118
            TRFE L  +   FGF+Y
Sbjct:  608 TRFETLSGFERCFGFLY 624

The following BLAST results are available for this feature:

BLAST of NCOA5 vs. Ensembl Human
BLAST of NCOA5 vs. Ensembl Celegans
BLAST of NCOA5 vs. Ensembl Fly
BLAST of NCOA5 vs. Ensembl Zebrafish
BLAST of NCOA5 vs. Ensembl Xenopus
BLAST of NCOA5 vs. Ensembl Mouse
BLAST of NCOA5 vs. UniProt/SwissProt
BLAST of NCOA5 vs. TrEMBL
BLAST of NCOA5 vs. Ensembl Cavefish
BLAST of NCOA5 vs. Ensembl Sea Lamprey
BLAST of NCOA5 vs. Ensembl Yeast
BLAST of NCOA5 vs. Ensembl Nematostella
BLAST of NCOA5 vs. Ensembl Medaka
BLAST of NCOA5 vs. Planmine SMEST

BLAST of NCOA5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
NCOA5	1.417e-7	27.54	nuclear receptor coactivator 5 [Source:HGNC Symbol...	[more]

BLAST of NCOA5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NCOA5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NCOA5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NCOA5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ncoa5	2.536e-9	28.28	nuclear receptor coactivator 5 [Source:NCBI gene;A...	[more]
ncoa5	2.708e-9	28.28	nuclear receptor coactivator 5 [Source:NCBI gene;A...	[more]
ENSXETT00000043220.1	1.000e-7	50.82	pep primary_assembly:Xenopus_tropicalis_v9.1:7:364...	[more]

BLAST of NCOA5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Ncoa5	6.445e-7	27.33	nuclear receptor coactivator 5 [Source:MGI Symbol;...	[more]

BLAST of NCOA5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2


Match Name	E-value	Identity	Description
sp\|Q9HCD5\|NCOA5_HUMAN	6.806e-7	27.54	Nuclear receptor coactivator 5 OS=Homo sapiens OX=...	[more]
sp\|Q91W39\|NCOA5_MOUSE	4.508e-6	27.33	Nuclear receptor coactivator 5 OS=Mus musculus OX=...	[more]

BLAST of NCOA5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
U6A492	3.408e-180	100.00	NCOA5 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1	[more]
A0A5N4AZG8	3.132e-17	45.37	Uncharacterized protein OS=Photinus pyralis OX=705...	[more]
A0A1Y1KMA7	1.744e-16	53.26	Dimer_Tnp_hAT domain-containing protein (Fragment)...	[more]
J9L841	1.504e-15	51.19	Dimer_Tnp_hAT domain-containing protein OS=Acyrtho...	[more]
N6UEN3	2.298e-15	52.17	Uncharacterized protein (Fragment) OS=Dendroctonus...	[more]

BLAST of NCOA5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000036272.1	2.486e-16	49.49	pep primary_assembly:Astyanax_mexicanus-2.0:20:119...	[more]
ENSAMXT00000055782.1	8.823e-11	48.05	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
ENSAMXT00000025204.2	1.768e-9	54.10	pep primary_assembly:Astyanax_mexicanus-2.0:12:736...	[more]
ENSAMXT00000033195.1	1.611e-8	53.45	pep primary_assembly:Astyanax_mexicanus-2.0:16:112...	[more]
ENSAMXT00000042715.1	2.055e-7	42.86	pep primary_assembly:Astyanax_mexicanus-2.0:16:118...	[more]

BLAST of NCOA5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NCOA5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NCOA5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO40596	7.075e-8	38.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35148	2.624e-7	49.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32247	2.754e-7	52.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO26036	3.826e-7	53.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33687	5.594e-7	51.02	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of NCOA5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ENSORLT00000028133.1	2.483e-10	42.17	zinc finger MYM-type protein 1-like [Source:NCBI g...	[more]
ENSORLT00000042294.1	2.483e-10	42.17	zinc finger MYM-type protein 1-like [Source:NCBI g...	[more]
ENSORLT00000045044.1	2.483e-10	42.17	zinc finger MYM-type protein 1-like [Source:NCBI g...	[more]

BLAST of NCOA5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000010804.1	0.000e+0	100.00	SMESG000010804.1	[more]
SMESG000078916.1	6.237e-20	39.23	SMESG000078916.1	[more]
SMESG000077250.1	2.840e-19	42.86	SMESG000077250.1	[more]
SMESG000026726.1	9.793e-19	44.23	SMESG000026726.1	[more]
SMESG000036749.1	1.577e-16	43.37	SMESG000036749.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30003730
GenBank	AHA14850.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30003730 ID=SMED30003730|Name=NCOA5|organism=Schmidtea mediterranea sexual|type=transcript|length=4514bp
ATGAACCAATATTTGATCCAAAGGCAAATTTTAAGATTAACTTTTATTTC
TAAGCATAGACCAAGCAACAAGATTCGAAGTGCTAAAATTGTATAATGAT
ATATTTGGATTTATGTATAATAATAAAGGTGAAATGGAAGAAATTAACTG
GCGAACAAAGAAATGAGTCTCATATTAATGGAATTGAGTTTTTCGAAGAG
ATAAAAACTATAAAAGTATTTTTAAAAGAAGATATTAAACCTCAATCTAT
ATTATTATATATTTTACAAAATGATCTTCAGGCAACATTCCCAAATATAT
TTATTGTGACGAGAATTTTATTGACATTAACAATCTCAGTTGCAACAAAT
GAAAGATCGTTTTCAAAATTAAAGATAATCAAAACTTATTTAAGATCAAC
TATGCTCCAGGAACGTCTAAGTCAGGGTTTCCCAAACTGTGTTCCTCGGA
GCCTAAATAGATATTTCACAAAAATTTGGAGTAAATTTAGAAAATTGAAC
GTATTCTACTTCATAATTAAAGACGAGTGACGGTTAAACTTTATTGAGTT
TTACGATGTCAAGAGCAGGCGAATGTTTTTAGTACCTAGAATTTGGGTAC
AGCAATAAAAGTCTTTAACAATTGCTAATATTTTTGAACGAGGGCGAAAG
ACTATCTCATCCTGTGCACATGAAAGAGATGTGATATGTGGAATTGTTTT
TACCTGATTCACTGAAATCTTGTTACTATGATCTTCGGTACGCGAAAGGA
CAGTTCGCTTTTTTGTGTTTACACATCAGACAGCCTCACGCAAATAGACT
CGACGCCACGGCAGATATGAGAATACAACTGACCAATATTGTGCCTGATG
TAAAAAAAATTTGTAATTATAGAACCCAAAATCATCAAAGTCACTAGGAG
TTTTATTTATTTGTATTTTTATGTATATTAAATAAATGATATTTCTTTAA
TAACATTTTTTTTATTTATACTATGAATTATTCAACCTAAAAAATAAGCT
AAGTGTTCCGCCAAAATTTTCGGATTTGTCAAGTGTTCCATCGCTGAAAA
AGTTTGGTAAACCTTGAAATAGACTATTATTGAAAAATTGTATTAATATT
AAACACTTGTAATATATTGATGTCGAAATTATTGTATTTCGATATTTGAA
AAGCTTTCGCTGAGGAACCTTAATATATCTACTAAATGCATTCACCTTCA
AAAATTACAGAACTTATTACCAACTAACGAAAATTGGCTGGATATGATGC
AATTGTTACAGGTCGGTCGATATCTACTCATTAAAATCAGATAGTACATA
AATACATACACAATTGCAATTATGGGCGCTCAAAACAAGAACAAATGTAT
TGATATGCTTATTTCAGTAGCATCGATGGAATTGGCTGATATTTTATTTA
AATATACTGATATTAACAAATCACAATATAAATATCAATATCAAAGTTTT
ATTTTAAGACTTTATTGTTTTAAAATTGTCAATTAGAATCTTAAATTCCT
ATAATGCTTGTCAAAATAGGGAAATTCGATATTTAAAAATCTTTTTAAAA
TATTTCACACTATTTTAATATTATGAATACGAGAAAAGTTTTATAAAAAC
AAAATATTTTAAGATTTTAATTGCGTACATTTAATATAACTTCAATTTTA
ATGATGTGCAAAAAGTAAAATATTCTCACAAGAAAAATGAAACAAATTTT
TTTAAAATTAATGAGTGGGCTAAAATAGGAATAGTGTTGGTTAATATTGT
TAATCATAATGTCAGCTACTAAAAAGCATCAGAAGTCAATGGACATAGTC
ATTTCATAAATAATTATCTGAAAATGCGTAATTAGTATCAAAAATGTTTT
TATTCCACCAGTTGCGCAAGATAATCATGGAGTTTGGTATCAACTACATT
TTATTTTCAAATAAATTCTAAATAATAAGTAATTTTTATTCATGAACTAA
ATCATGTTTCACTACCAAAAATCCTCAGATTCGAAACTTCCAGTTCTGAA
ATGAAAACCAGTATCAACTAAAATTAATTATTATAAGAGGAATTATTTGA
AAATAATTTTACTTATTTGTTTATTTATATATTTGTCAGATTAAAAATTT
CAGAAAAAATTTGTAGATTGTAAAAAATCAACTAATAATTATATAATTAA
TTTGCTTTTGCACGTTTAAAAAGAAAAATGATTCTTAAAAAATAGCTTAA
GCAGCTTGCTGTTTATTTTACCGGGTTTAACAAATTTTGTACATCGTTTG
AAGTTCATAAGTTTGCCTATCTGATATTTTTATAAAGTGACGAAATCTCC
CGAACTATTTTGAAAATAATTGGAGATTTATGTTTGACAAAGTTGGTACA
TTTATTCTAATTAAGGGCCATCCATATATTTTGTATACATCGAATATGTT
CGGAGTGATTAATTTGAAAGGAAGAGAGTGCTGAAACCAAGGGAAATTAA
ATCAATAACTCAAATGCTACGAAATTTTAGTTTTGTTATTGATTAATATT
AAATTAAGTTTATCTTTGTGTTAACACGTATTTTATGTACATATATTATA
TAAGACACATGATTAAAATCATTGATGGCTTACCTATTTTATTGAAAGTT
TTAATTGAATAACCTTTATGTTCTTTCTGATTGTGATTCATCGGCAGAAA
AACATGAAGTCGAAAGACGCCAATAATTATTATTGTCCTGATTAATTATT
AGGGTAGAATTATATTTTACTTACATTATATATAGACACCAACTTGCGGT
AGTAAACACTAATTGTACATATTGTCGATTTTACATTCAATTAACACTGT
TTACATAATCACACCTATAAGTATTATGCACTATCTATTGTAATTTCCTT
CTAACTTTTGCATTAATACTTTTTTAAAATTTTGGTTATAGTGAGAGCTT
ATACCGATGAGAAATATTAAATTTCTTATTAATTTTTCAATTTTAAGTGA
TTACAAAATTTAATGATTGAGTTTCTAGAACATCGCAACATGCCATTAAA
TAATGCTTTAACATTTGTTGCTCGTAACTTCGAAAGATATCAAAAGCATG
TACGGGATTTAAAAACTATTGCCCCAAAACCAACATTTGATCCATCAAGA
ATGCCTCCAGGATTTATAGCACCGGATGATAAAATCATTTATTATTTGCA
TTTGCTGGCAGATTCCAGGATGTTGACTATTGAAGAGTTAAATGAGGTGA
TAGATTTTGTACAAAAAAGAATGCAAGCATTGGCAAGTGCAGAAGAAACA
ATGGAAAAAGCTCCAATTACAGGCTTGCCAAATGAATCAGTACAAAACTC
GATGGCTCCTAAACTTTCAATACCAGGAAATCAACCAGTTCGAGAGGAAA
AAGTAATTCAACATCAAACTCAATTGCATTCTAAAATATTAAATATACTA
AAACCTGTCCCACATCAATCTGCTTCAGGTGTTGTGGATAATGAAATAAA
TAATATGGAACAATTCAATACATATAATGATTCTAATATATCAACATCGA
AGAGTAATAACATGGTTATTAATCCAAAAGTTCAACAAGCATTGGATACG
TTAATGCAATCGCAATTTAGACCAACTGCTCCTGAGCTAAGTGCTCCCGC
GGAAGAAAATTCTCGTAACTTTCAACCAGTTAATAATCCAATGGCAAATC
CATATTCAATGAATCCTACTCCAAATATGAGGCCTATTAATCCTCATTCT
ACTCAACAAAGACCAATGGCTCAAGGGCCAGGTGGACAGCCATTTGGAAA
TAGTTTCCATGGATATTATCAGCCACCAATAGGTCAACCAATTTTCAGGG
GTAGACCGCCTTTTCAACCTAGACCCCAATATCCTGGATATTAAAATATC
TGAATAATTATTGTGTGTCATTTAAAAATAGTTATTTTAATTGAAATTAT
TAAGTGTCGTTTATAAAAATAATTTTAAACAGAATGGAAATATGGTTAAG
CGATAATTTTTGGTATTAATTCAATACTCTGATTTTATCGACTAAATATA
TAGACGACTGTATTAAAGTAAAAATTTAAATCTTGAAAAGGCTAGATACA
GATATTTATTGTGATGAATACTGTTTAGTTTTTAGCTGGATTTCTCATAA
TTTTCATGAACAAATGAAACTGCAATGGAAATTTAATAACGTTAATTAAA
ATATTAGTTGCTTAAATGAATTTTAAACTTTATTTTTGAACAGTGTTAAA
AACAAGAGGATTTTAAAAATATTGACTAGAGATAAAATTATGTTAAAATT
TCACTACCTTTATGTAAATGGTTAAAATTAATAGGTAAATGAATTATGTG
TATATTGTTATTTTATAAACTTCAATCTTAAATATCAAAAATACAATTCA
ATATTTAAAAAATTTATTTTTATTATGTAAGTATTTAATGCGATAGCAGA
CTATAAATGTTAATGTGACATCAGTATTTTATGTATTATTTCAGACAATT
GTCATTTTATTCGACCCTAAATTATTACTTTAATCGTAATTTATTTTAAC
AATTTTATTATTAT

protein sequence of SMED30003730-orf-1

>SMED30003730-orf-1 ID=SMED30003730-orf-1|Name=SMED30003730-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=145bp
MIYLDLCIIIKVKWKKLTGEQRNESHINGIEFFEEIKTIKVFLKEDIKPQ
SILLYILQNDLQATFPNIFIVTRILLTLTISVATNERSFSKLKIIKTYLR
STMLQERLSQGFPNCVPRSLNRYFTKIWSKFRKLNVFYFIIKDE*

protein sequence of SMED30003730-orf-2

>SMED30003730-orf-2 ID=SMED30003730-orf-2|Name=SMED30003730-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=294bp
MIEFLEHRNMPLNNALTFVARNFERYQKHVRDLKTIAPKPTFDPSRMPPG
FIAPDDKIIYYLHLLADSRMLTIEELNEVIDFVQKRMQALASAEETMEKA
PITGLPNESVQNSMAPKLSIPGNQPVREEKVIQHQTQLHSKILNILKPVP
HQSASGVVDNEINNMEQFNTYNDSNISTSKSNNMVINPKVQQALDTLMQS
QFRPTAPELSAPAEENSRNFQPVNNPMANPYSMNPTPNMRPINPHSTQQR
PMAQGPGGQPFGNSFHGYYQPPIGQPIFRGRPPFQPRPQYPGY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0046983	protein dimerization activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036621	Anticodon-bd_dom_sf
IPR004154	Anticodon-bd
IPR008906	HATC_C_dom

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 73..93
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 276..293
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 272..293
None	No IPR available	PANTHER	PTHR23295	NUCLEAR RECEPTOR COACTIVATOR 5-RELATED	coord: 6..228
IPR036621	Anticodon-binding domain superfamily	GENE3D	G3DSA:3.40.50.800		coord: 3..34 e-value: 3.1E-6 score: 28.7

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NCOA5

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Owlery

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