mitfl-3 protein

Overview


Name	mitfl-3 protein (AGZ94934.1)
Smed ID	SMED30003618
Length (bp)	1733

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of mitfl-3 protein (SMED30003618) t-SNE clustered cells

Violin plots show distribution of expression levels for mitfl-3 protein (SMED30003618) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of mitfl-3 protein (SMED30003618) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for mitfl-3 protein (SMED30003618) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30003618

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
central nervous system	SMED30003618	h1SMcG0014602	KF487119	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
progenitor cell	SMED30003618	h1SMcG0014602	KF487119	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
stem cell	SMED30003618	h1SMcG0014602	KF487119	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
parenchyma	SMED30003618	h1SMcG0014602	KF487119	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of mitfl-3 protein vs. Ensembl Human
Match: TFEB (transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753])

HSP 1 Score: 57.3806 bits (137), Expect = 3.119e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:   88 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGMNMAELA 200

[Close]

BLAST of mitfl-3 protein vs. Ensembl Human
Match: TFEB (transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753])

HSP 1 Score: 57.3806 bits (137), Expect = 3.577e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  145 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGMNMAELA 257

[Close]

BLAST of mitfl-3 protein vs. Ensembl Human
Match: TFEB (transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753])

HSP 1 Score: 57.7658 bits (138), Expect = 3.878e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  244 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGMNMAELA 356

[Close]

BLAST of mitfl-3 protein vs. Ensembl Human
Match: TFEB (transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753])

HSP 1 Score: 57.3806 bits (137), Expect = 4.428e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  230 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGMNMAELA 342

[Close]

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  230 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGMNMAELA 342

[Close]

BLAST of mitfl-3 protein vs. Ensembl Celegans
Match: hlh-30 (Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86MJ3])

HSP 1 Score: 55.4546 bits (132), Expect = 6.293e-8
Identity = 26/56 (46.43%), Postives = 40/56 (71.43%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI 574
            +D+ KK+ HN +ER+RR  IN +I++L ++LP     + D+K+NKG ILK S +YI
Sbjct:  175 RDRRKKDIHNMIERRRRYNINDRIKELGQMLPKN--TSEDMKLNKGTILKASCDYI 228

[Close]

BLAST of mitfl-3 protein vs. Ensembl Celegans
Match: hlh-30 (Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86MJ3])

HSP 1 Score: 55.4546 bits (132), Expect = 6.354e-8
Identity = 26/56 (46.43%), Postives = 40/56 (71.43%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI 574
            +D+ KK+ HN +ER+RR  IN +I++L ++LP     + D+K+NKG ILK S +YI
Sbjct:  184 RDRRKKDIHNMIERRRRYNINDRIKELGQMLPKN--TSEDMKLNKGTILKASCDYI 237

[Close]

BLAST of mitfl-3 protein vs. Ensembl Celegans
Match: hlh-30 (Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86MJ3])

HSP 1 Score: 55.0694 bits (131), Expect = 6.881e-8
Identity = 26/56 (46.43%), Postives = 40/56 (71.43%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI 574
            +D+ KK+ HN +ER+RR  IN +I++L ++LP     + D+K+NKG ILK S +YI
Sbjct:   97 RDRRKKDIHNMIERRRRYNINDRIKELGQMLPKN--TSEDMKLNKGTILKASCDYI 150

[Close]

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI 574
            +D+ KK+ HN +ER+RR  IN +I++L ++LP     + D+K+NKG ILK S +YI
Sbjct:   97 RDRRKKDIHNMIERRRRYNINDRIKELGQMLPKN--TSEDMKLNKGTILKASCDYI 150

[Close]

BLAST of mitfl-3 protein vs. Ensembl Celegans
Match: hlh-30 (Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86MJ3])

HSP 1 Score: 55.4546 bits (132), Expect = 7.239e-8
Identity = 26/56 (46.43%), Postives = 40/56 (71.43%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI 574
            +D+ KK+ HN +ER+RR  IN +I++L ++LP     + D+K+NKG ILK S +YI
Sbjct:  235 RDRRKKDIHNMIERRRRYNINDRIKELGQMLPKN--TSEDMKLNKGTILKASCDYI 288

[Close]

BLAST of mitfl-3 protein vs. Ensembl Fly
Match: Mitf (gene:FBgn0263112 transcript:FBtr0307326)

HSP 1 Score: 58.9214 bits (141), Expect = 1.012e-8
Identity = 32/68 (47.06%), Postives = 46/68 (67.65%), Query Frame = 2

Query:  395 NQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLP--TEFFLNC--DLKMNKGVILKNSVEYITSMK 586
            N L KD+ KK+ HN +ER+RR  IN +I++L  LLP  ++ F     D++ NKG ILK+SV+YI  +K
Sbjct:  393 NALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLK 460

[Close]

BLAST of mitfl-3 protein vs. Ensembl Fly
Match: Mitf (gene:FBgn0263112 transcript:FBtr0307327)

HSP 1 Score: 58.9214 bits (141), Expect = 1.012e-8
Identity = 32/68 (47.06%), Postives = 46/68 (67.65%), Query Frame = 2

Query:  395 NQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLP--TEFFLNC--DLKMNKGVILKNSVEYITSMK 586
            N L KD+ KK+ HN +ER+RR  IN +I++L  LLP  ++ F     D++ NKG ILK+SV+YI  +K
Sbjct:  393 NALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLK 460

[Close]

BLAST of mitfl-3 protein vs. Ensembl Fly
Match: Mitf (gene:FBgn0263112 transcript:FBtr0307329)

HSP 1 Score: 58.9214 bits (141), Expect = 1.057e-8
Identity = 32/68 (47.06%), Postives = 46/68 (67.65%), Query Frame = 2

Query:  395 NQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLP--TEFFLNC--DLKMNKGVILKNSVEYITSMK 586
            N L KD+ KK+ HN +ER+RR  IN +I++L  LLP  ++ F     D++ NKG ILK+SV+YI  +K
Sbjct:  367 NALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLK 434

[Close]

BLAST of mitfl-3 protein vs. Ensembl Fly
Match: Mitf (gene:FBgn0263112 transcript:FBtr0307328)

HSP 1 Score: 58.9214 bits (141), Expect = 1.146e-8
Identity = 32/68 (47.06%), Postives = 46/68 (67.65%), Query Frame = 2

Query:  395 NQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLP--TEFFLNC--DLKMNKGVILKNSVEYITSMK 586
            N L KD+ KK+ HN +ER+RR  IN +I++L  LLP  ++ F     D++ NKG ILK+SV+YI  +K
Sbjct:  500 NALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLK 567

[Close]

BLAST of mitfl-3 protein vs. Ensembl Zebrafish
Match: mitfa (melanocyte inducing transcription factor a [Source:ZFIN;Acc:ZDB-GENE-990910-11])

HSP 1 Score: 53.9138 bits (128), Expect = 2.525e-7
Identity = 30/77 (38.96%), Postives = 47/77 (61.04%), Query Frame = 2

Query:  383 PFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL 613
            P     L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q   +L
Sbjct:  125 PVEVRALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQKEQQKAKEL 199

[Close]

BLAST of mitfl-3 protein vs. Ensembl Zebrafish
Match: tfe3a (transcription factor binding to IGHM enhancer 3a [Source:ZFIN;Acc:ZDB-GENE-010919-2])

HSP 1 Score: 53.9138 bits (128), Expect = 3.868e-7
Identity = 36/98 (36.73%), Postives = 54/98 (55.10%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI--------------TSMKLVEQINHQL---IHENELGAKL 643
            ++K++ KK+ HN +ER+RR  IN +I++L  L+P     + +L+ NKG ILK SV+YI              T  K +E  N  L   I E E+ A+L
Sbjct:  311 IMKERQKKDNHNLIERRRRFNINDRIKELGALIPKSS--DPELRWNKGTILKASVDYIRKLQKEQQRSKEMETRQKKLEHANRSLMLRIQELEMQARL 406

[Close]

BLAST of mitfl-3 protein vs. Ensembl Zebrafish
Match: mitfa (melanocyte inducing transcription factor a [Source:ZFIN;Acc:ZDB-GENE-990910-11])

HSP 1 Score: 53.5286 bits (127), Expect = 4.271e-7
Identity = 29/71 (40.85%), Postives = 46/71 (64.79%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL 613
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q   +L
Sbjct:  194 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQKEQQKAKEL 262

[Close]

BLAST of mitfl-3 protein vs. Ensembl Zebrafish
Match: tfe3a (transcription factor binding to IGHM enhancer 3a [Source:ZFIN;Acc:ZDB-GENE-010919-2])

HSP 1 Score: 52.7582 bits (125), Expect = 5.288e-7
Identity = 27/71 (38.03%), Postives = 48/71 (67.61%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL 613
            ++K++ KK+ HN +ER+RR  IN +I++L  L+P     + +L+ NKG ILK SV+YI  ++  +Q + ++
Sbjct:   67 IMKERQKKDNHNLIERRRRFNINDRIKELGALIPKSS--DPELRWNKGTILKASVDYIRKLQKEQQRSKEM 135

[Close]

BLAST of mitfl-3 protein vs. Ensembl Zebrafish
Match: mitfb (melanocyte inducing transcription factor b [Source:ZFIN;Acc:ZDB-GENE-010919-1])

HSP 1 Score: 53.1434 bits (126), Expect = 5.788e-7
Identity = 53/195 (27.18%), Postives = 89/195 (45.64%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYA----------IHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRN 904
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  +              K +E  N  L   I E E+ A+       ++   +  S L  +E L   A  +EP +G      Y           + + +   L   T   S++ L+  ++ + DDI+M+    + + N
Sbjct:  290 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQHRTKELENRQKKLEHTNRNLLLRIQELEIQAR-------AHGLAMASSALCASE-LAARAIKQEPLLGDCSQDMYTSTHAHPSCADMSRSSTLDLNNGTISFSDTHLSDTHAAKLDDILMDETLTSGATN 474

[Close]

BLAST of mitfl-3 protein vs. Ensembl Xenopus
Match: tfeb (transcription factor EB [Source:NCBI gene;Acc:780105])

HSP 1 Score: 60.077 bits (144), Expect = 5.977e-9
Identity = 33/81 (40.74%), Postives = 53/81 (65.43%), Query Frame = 2

Query:  392 NNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL-IHENEL 631
            N  L++++ KK+THN +ER+RR  IN +I++L  L+P    L+ D + NKG IL+ SV+YI  M+  +Q + +L  H  +L
Sbjct:  220 NRALVRERQKKDTHNMIERRRRFNINDRIKELGTLIPKTNELS-DTRWNKGTILRASVDYIKHMQKEQQKSRELETHSRQL 299

[Close]

BLAST of mitfl-3 protein vs. Ensembl Xenopus
Match: ipo9 (importin 9 [Source:Xenbase;Acc:XB-GENE-5960761])

HSP 1 Score: 52.7582 bits (125), Expect = 8.318e-7
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q
Sbjct:  146 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQ 209

[Close]

BLAST of mitfl-3 protein vs. Ensembl Xenopus
Match: ipo9 (importin 9 [Source:Xenbase;Acc:XB-GENE-5960761])

HSP 1 Score: 53.1434 bits (126), Expect = 9.458e-7
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q
Sbjct:  288 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQ 351

[Close]

BLAST of mitfl-3 protein vs. Ensembl Xenopus
Match: ipo9 (importin 9 [Source:Xenbase;Acc:XB-GENE-5960761])

HSP 1 Score: 52.7582 bits (125), Expect = 1.048e-6
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q
Sbjct:  235 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQ 298

[Close]

BLAST of mitfl-3 protein vs. Ensembl Xenopus
Match: ipo9 (importin 9 [Source:Xenbase;Acc:XB-GENE-5960761])

HSP 1 Score: 52.7582 bits (125), Expect = 1.065e-6
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q
Sbjct:  234 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQ 297

[Close]

BLAST of mitfl-3 protein vs. Ensembl Mouse
Match: Tfeb (transcription factor EB [Source:MGI Symbol;Acc:MGI:103270])

HSP 1 Score: 56.6102 bits (135), Expect = 3.597e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:   88 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGVNMAELA 200

[Close]

BLAST of mitfl-3 protein vs. Ensembl Mouse
Match: Tfeb (transcription factor EB [Source:MGI Symbol;Acc:MGI:103270])

HSP 1 Score: 56.9954 bits (136), Expect = 3.942e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  229 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGVNMAELA 341

[Close]

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  229 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGVNMAELA 341

[Close]

BLAST of mitfl-3 protein vs. Ensembl Mouse
Match: Tfeb (transcription factor EB [Source:MGI Symbol;Acc:MGI:103270])

HSP 1 Score: 56.9954 bits (136), Expect = 4.996e-8
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  288 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGVNMAELA 400

[Close]

BLAST of mitfl-3 protein vs. Ensembl Mouse
Match: Tfe3 (transcription factor E3 [Source:MGI Symbol;Acc:MGI:98511])

HSP 1 Score: 54.6842 bits (130), Expect = 2.110e-7
Identity = 44/130 (33.85%), Postives = 68/130 (52.31%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL----------IRSLISSNYTD-LNCSQLSINE 706
            L+K++ KK+ HN +ER+RR  IN +I++L  L+P     + +++ NKG ILK SV+YI  +              + +EQ N  L   I E EL A++          + SL +S+ +D L   QL I E
Sbjct:  235 LLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEE 362

[Close]

BLAST of mitfl-3 protein vs. UniProt/SwissProt
Match: sp|P19484|TFEB_HUMAN (Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3)

HSP 1 Score: 57.3806 bits (137), Expect = 2.126e-7
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  230 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGMNMAELA 342

[Close]

BLAST of mitfl-3 protein vs. UniProt/SwissProt
Match: sp|P19532|TFE3_HUMAN (Transcription factor E3 OS=Homo sapiens OX=9606 GN=TFE3 PE=1 SV=4)

HSP 1 Score: 57.3806 bits (137), Expect = 2.439e-7
Identity = 45/138 (32.61%), Postives = 70/138 (50.72%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL----------IRSLISSNYTD-LNCSQLSINENLNYGAGN 730
            L+K++ KK+ HN +ER+RR  IN +I++L  L+P     + +++ NKG ILK SV+YI  +              + +EQ N  L   I E EL A++          + SL +++ +D L   QL I E    GA  
Sbjct:  341 LLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAAT 476

[Close]

BLAST of mitfl-3 protein vs. UniProt/SwissProt
Match: sp|Q9R210|TFEB_MOUSE (Transcription factor EB OS=Mus musculus OX=10090 GN=Tfeb PE=1 SV=2)

HSP 1 Score: 56.9954 bits (136), Expect = 2.758e-7
Identity = 39/116 (33.62%), Postives = 65/116 (56.03%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKLIRSLISSNYTDLNCSQLS 697
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  M              + +E  N QL   I E E+ A+ +  L +++ + +N ++L+
Sbjct:  229 LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAN--DLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQAR-VHGLPTTSPSGVNMAELA 341

[Close]

BLAST of mitfl-3 protein vs. UniProt/SwissProt
Match: sp|P49379|CBF1_KLULA (Centromere-binding protein 1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) OX=284590 GN=CBF1 PE=1 SV=2)

HSP 1 Score: 55.4546 bits (132), Expect = 5.934e-7
Identity = 32/86 (37.21%), Postives = 48/86 (55.81%), Query Frame = 2

Query:  413 KHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQIN-HQLIHENELGAKLIRSLISSN 667
            + +KE+H  VER+RR  IN  I+KL++LLP +       + +K  IL  + EYI  MK  E  N  +   +  LG + + SL S+N
Sbjct:  248 QQRKESHKEVERRRRQNINTAIEKLSDLLPVK-------ETSKAAILSRAAEYIQKMKETETANIEKWTLQKLLGEQQVSSLTSAN 326

[Close]

BLAST of mitfl-3 protein vs. UniProt/SwissProt
Match: sp|Q05B92|TFE3_BOVIN (Transcription factor E3 OS=Bos taurus OX=9913 GN=TFE3 PE=2 SV=1)

HSP 1 Score: 55.0694 bits (131), Expect = 1.284e-6
Identity = 43/135 (31.85%), Postives = 69/135 (51.11%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL----------IRSLISSNYTD-LNCSQLSINENLNYG 721
            L+K++ KK+ HN +ER+RR  IN +I++L  L+P     + +++ NKG ILK SV+YI  +              + +EQ N  L   I E EL A++          + SL +++ +D L   QL + E    G
Sbjct:  339 LLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLAATSASDSLKPEQLDVEEEGRPG 471

[Close]

BLAST of mitfl-3 protein vs. TrEMBL
Match: U5YTC8 (Mitfl-3 protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=mitfl-3 PE=2 SV=1)

HSP 1 Score: 803.127 bits (2073), Expect = 0.000e+0
Identity = 399/406 (98.28%), Postives = 401/406 (98.77%), Query Frame = 2

Query:  224 KRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSNVQLISDKSSPVLNGLLKKSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNVDSIKECKFFYSKEKT----YYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL 1429
            KRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAG+EEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDS NNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSNVQLISDKSSPVLNGLLKKSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNVDSIKECKFFYSKEKT    YYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFN+SNDPMLLSSSPTHL
Sbjct:    1 KRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGSEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSINNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSNVQLISDKSSPVLNGLLKKSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNVDSIKECKFFYSKEKTKLFQYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNESNDPMLLSSSPTHL 406

[Close]

BLAST of mitfl-3 protein vs. TrEMBL
Match: A0A068WCM7 (Microphthalmia associated transcription factor OS=Echinococcus granulosus OX=6210 GN=EgrG_000774700 PE=4 SV=1)

HSP 1 Score: 93.2041 bits (230), Expect = 5.268e-16
Identity = 53/131 (40.46%), Postives = 74/131 (56.49%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQ 793
            +I+ + KK++HNR+ERKRRD+INCQI +L  LLP E F   D K NKG ILKNSVEYI++++        L +E  L   +I  L+     DL    L  +E L   A     D   ++ +W  +H  N+Q
Sbjct:  296 MIRARSKKDSHNRIERKRRDYINCQITELGTLLPEEMFRENDCKKNKGSILKNSVEYISALQRENHCYADLYNETNLANSVIDRLV-KRIQDLE--SLLPSEYLTKVALAGPADYRQMLQEWSKLHDSNQQ 423

[Close]

BLAST of mitfl-3 protein vs. TrEMBL
Match: A0A4S2M3M1 (BHLH domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002952 PE=4 SV=1)

HSP 1 Score: 93.2041 bits (230), Expect = 5.931e-16
Identity = 52/131 (39.69%), Postives = 74/131 (56.49%), Query Frame = 2

Query:  404 IKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISS-NYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQ 793
            ++D+ KK++HNR+ERKRRD+INCQI +L  LLP E F + D K NKG ILKNSVE+I  ++       ++  E  L AK+I  LI    Y +  C     +  L+ G      D    + +W  +H+ N Q
Sbjct:  386 VRDRTKKDSHNRIERKRRDYINCQISELGNLLPEEMFRDGDCKKNKGSILKNSVEFICLLRAELSQLSEVRRETNLAAKVIGQLIKRIQYLEEVCGISQGSNTLDLG----NLDYHRCLQEWLLLHERNTQ 512

[Close]

BLAST of mitfl-3 protein vs. TrEMBL
Match: G7Y7J8 (Transcription factor EB OS=Clonorchis sinensis OX=79923 GN=CLF_102233 PE=4 SV=1)

HSP 1 Score: 93.2041 bits (230), Expect = 6.306e-16
Identity = 52/131 (39.69%), Postives = 74/131 (56.49%), Query Frame = 2

Query:  404 IKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISS-NYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQ 793
            ++D+ KK++HNR+ERKRRD+INCQI +L  LLP E F + D K NKG ILKNSVE+I  ++       ++  E  L AK+I  LI    Y +  C     +  L+ G      D    + +W  +H+ N Q
Sbjct:  386 VRDRTKKDSHNRIERKRRDYINCQISELGNLLPEEMFRDGDCKKNKGSILKNSVEFICLLRAELSQLSEVRRETNLAAKVIGQLIKRIQYLEEVCGISQGSNTLDLG----NLDYHRCLQEWLLLHERNTQ 512

[Close]

BLAST of mitfl-3 protein vs. TrEMBL
Match: A0A3R7CHW0 (Transcription factor EB OS=Clonorchis sinensis OX=79923 GN=Tfeb PE=4 SV=1)

HSP 1 Score: 93.2041 bits (230), Expect = 6.417e-16
Identity = 52/131 (39.69%), Postives = 74/131 (56.49%), Query Frame = 2

Query:  404 IKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISS-NYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQ 793
            ++D+ KK++HNR+ERKRRD+INCQI +L  LLP E F + D K NKG ILKNSVE+I  ++       ++  E  L AK+I  LI    Y +  C     +  L+ G      D    + +W  +H+ N Q
Sbjct:  386 VRDRTKKDSHNRIERKRRDYINCQISELGNLLPEEMFRDGDCKKNKGSILKNSVEFICLLRAELSQLSEVRRETNLAAKVIGQLIKRIQYLEEVCGISQGSNTLDLG----NLDYHRCLQEWLLLHERNTQ 512

[Close]

BLAST of mitfl-3 protein vs. Ensembl Cavefish
Match: mitfa (melanocyte inducing transcription factor a [Source:ZFIN;Acc:ZDB-GENE-990910-11])

HSP 1 Score: 55.0694 bits (131), Expect = 1.315e-7
Identity = 27/66 (40.91%), Postives = 45/66 (68.18%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            ++K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q
Sbjct:  183 MVKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQ 246

[Close]

BLAST of mitfl-3 protein vs. Ensembl Cavefish
Match: tfeb (transcription factor EB [Source:NCBI gene;Acc:103036573])

HSP 1 Score: 54.299 bits (129), Expect = 2.319e-7
Identity = 37/98 (37.76%), Postives = 54/98 (55.10%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL 643
            + K++ KK+ HN +ER+RR  IN +I++L  ++P    L  D++ NKG IL+ SVEYI  M              K +E  N QL   I E E+ A+L
Sbjct:  220 MAKERQKKDNHNLIERRRRFNINDRIKELGTMIPKTNDL--DVRWNKGTILRASVEYIKRMQKDVQRTREVENNFKRMEVANKQLWLRIQELEMQARL 315

[Close]

BLAST of mitfl-3 protein vs. Ensembl Cavefish
Match: tfe3b (transcription factor binding to IGHM enhancer 3b [Source:ZFIN;Acc:ZDB-GENE-010919-3])

HSP 1 Score: 54.299 bits (129), Expect = 2.583e-7
Identity = 30/86 (34.88%), Postives = 53/86 (61.63%), Query Frame = 2

Query:  329 SSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMK 586
            S P D  ++K  + +  +      L+K++ KK+ HN +ER+RR  IN +I++L  L+P    ++ +++ NKG ILK SV+YI  ++
Sbjct:  255 SCPADLPKIKTELTDVEA----KALMKERQKKDNHNLIERRRRFNINDRIKELGALIPKS--VDPEMRWNKGTILKASVDYIRKLQ 334

[Close]

BLAST of mitfl-3 protein vs. Ensembl Cavefish
Match: tfeb (transcription factor EB [Source:NCBI gene;Acc:103036573])

HSP 1 Score: 54.299 bits (129), Expect = 2.738e-7
Identity = 37/98 (37.76%), Postives = 54/98 (55.10%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL 643
            + K++ KK+ HN +ER+RR  IN +I++L  ++P    L  D++ NKG IL+ SVEYI  M              K +E  N QL   I E E+ A+L
Sbjct:  236 MAKERQKKDNHNLIERRRRFNINDRIKELGTMIPKTNDL--DVRWNKGTILRASVEYIKRMQKDVQRTREVENNFKRMEVANKQLWLRIQELEMQARL 331

[Close]

BLAST of mitfl-3 protein vs. Ensembl Cavefish
Match: tfe3a (transcription factor E3 [Source:NCBI gene;Acc:103028851])

HSP 1 Score: 53.9138 bits (128), Expect = 3.425e-7
Identity = 27/58 (46.55%), Postives = 40/58 (68.97%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYI 574
            LIK++ KK+ HN +ER+RR  IN +I++L  L+P       +++ NKG ILK SV+YI
Sbjct:  333 LIKERQKKDNHNLIERRRRFNINDRIKELGALVPKSSD-PSEMRWNKGTILKASVDYI 389

[Close]

BLAST of mitfl-3 protein vs. Ensembl Sea Lamprey
Match: mitfa (melanocyte inducing transcription factor a [Source:ZFIN;Acc:ZDB-GENE-990910-11])

HSP 1 Score: 57.7658 bits (138), Expect = 1.226e-9
Identity = 47/143 (32.87%), Postives = 72/143 (50.35%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQLI---HENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIH 778
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  +              + +EQ N  LI    E E+ A+    L SS+ T L    L+  + +       EPD+G L    +A+ 
Sbjct:    7 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRRLQKEQQRVKEMENRQRRLEQTNRGLIMRMQELEMQAR-AHGLPSSSPTGLTTGDLNGQQLIKA-----EPDMGGLQRLDFALQ 141

[Close]

BLAST of mitfl-3 protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009530.1 (pep scaffold:Pmarinus_7.0:GL478885:25441:30908:1 gene:ENSPMAG00000008619.1 transcript:ENSPMAT00000009530.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.1434 bits (126), Expect = 8.738e-9
Identity = 27/62 (43.55%), Postives = 43/62 (69.35%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMK 586
            L+K++ KKE+HN +ER+RR  IN +I++L  L+      + D++ NKG ILK SV+YI  ++
Sbjct:    7 LVKERRKKESHNLIERRRRFNINDRIKELGALITKSS--DPDIRWNKGTILKASVDYIRRLQ 66

[Close]

BLAST of mitfl-3 protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001124.1 (pep scaffold:Pmarinus_7.0:GL489212:1887:7231:1 gene:ENSPMAG00000001002.1 transcript:ENSPMAT00000001124.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.6842 bits (130), Expect = 2.264e-8
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            ++K++ KK+ HN +ER+RR  IN +I++L  L+P     + D + NKG ILK SV+YI  M+  +Q
Sbjct:  254 IVKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPDTRWNKGTILKASVDYIRRMQKEQQ 317

[Close]

BLAST of mitfl-3 protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001122.1 (pep scaffold:Pmarinus_7.0:GL489212:1806:7231:1 gene:ENSPMAG00000001002.1 transcript:ENSPMAT00000001122.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.299 bits (129), Expect = 3.819e-8
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQ 598
            ++K++ KK+ HN +ER+RR  IN +I++L  L+P     + D + NKG ILK SV+YI  M+  +Q
Sbjct:  268 IVKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPDTRWNKGTILKASVDYIRRMQKEQQ 331

[Close]

BLAST of mitfl-3 protein vs. Ensembl Yeast
Match: RTG3 (bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p [Source:SGD;Acc:S000000199])

HSP 1 Score: 53.5286 bits (127), Expect = 5.608e-8
Identity = 26/69 (37.68%), Postives = 42/69 (60.87%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFF----LNCDLKMNKGVILKNSVEYITSMKLVEQI 601
            K + K+E HN VER+RR+ I  +I++L +L+P        L   +K NKG+IL  +VEY+  +  + +I
Sbjct:  282 KLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDLGKQIKPNKGIILDRTVEYLQYLAEILEI 350

[Close]

BLAST of mitfl-3 protein vs. Ensembl Nematostella
Match: EDO39334 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAA2])

HSP 1 Score: 58.5362 bits (140), Expect = 1.079e-9
Identity = 36/109 (33.03%), Postives = 56/109 (51.38%), Query Frame = 2

Query:  326 ESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM-----KLVEQI--NHQLIHENEL 631
            +S P     + P  +   S     +  +D+ ++ THN VER+RRD IN  I KLA+++P           +KG IL  +V+YIT +     ++ E I  + QL  +NEL
Sbjct:  100 QSGPGAQRSIAPRTHQLGSKLEGPRGARDEKRRATHNEVERRRRDKINGWITKLAKVVPDCSSDQTKTGQSKGGILAKTVDYITDLRAANARMAETIKDSEQLAIDNEL 208

[Close]

BLAST of mitfl-3 protein vs. Ensembl Nematostella
Match: EDO44411 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVM3])

HSP 1 Score: 59.6918 bits (143), Expect = 1.431e-9
Identity = 34/80 (42.50%), Postives = 49/80 (61.25%), Query Frame = 2

Query:  395 NQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYIT-------SMKLVEQINHQL 613
            N L +D+ KK+ HN +ER+RR  IN +I++L  +LP +   + D + NKG ILK SV+YI         MKL+E+   QL
Sbjct:  269 NMLARDRQKKDNHNMIERRRRFNINDRIKELGTMLPKQ---DPDSRQNKGTILKASVDYIRNLKKDVDKMKLIEEEKRQL 345

[Close]

BLAST of mitfl-3 protein vs. Ensembl Nematostella
Match: EDO28110 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7E1])

HSP 1 Score: 52.7582 bits (125), Expect = 2.170e-8
Identity = 32/82 (39.02%), Postives = 48/82 (58.54%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM-----KLVEQI--NHQLIHENEL 631
            +D+ ++ THN VER+RRD IN  I KLA+++P           +KG IL  +V+YIT +     ++ E I  + QL  +NEL
Sbjct:   21 RDEKRRATHNEVERRRRDKINGWITKLAKVVPDCSSDQTKTGQSKGGILAKTVDYITDLRAANARMAETIKDSEQLAIDNEL 102

[Close]

BLAST of mitfl-3 protein vs. Ensembl Medaka
Match: tfe3b (transcription factor binding to IGHM enhancer 3 [Source:NCBI gene;Acc:101166296])

HSP 1 Score: 55.0694 bits (131), Expect = 1.560e-7
Identity = 36/98 (36.73%), Postives = 55/98 (56.12%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL 643
            ++K++ KK+ HN +ER+RR  IN +I++L  L+P     +  ++ NKG ILK SV+YI  +              K +EQ NH L   I E E+ A+L
Sbjct:  274 MLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPYMRWNKGTILKASVDYIRKLQKEQQRAKDVEVRQKKLEQANHILMLRIQELEMQARL 369

[Close]

BLAST of mitfl-3 protein vs. Ensembl Medaka
Match: tfeb (transcription factor EB [Source:NCBI gene;Acc:101158436])

HSP 1 Score: 54.6842 bits (130), Expect = 1.745e-7
Identity = 37/96 (38.54%), Postives = 53/96 (55.21%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSM--------------KLVEQINHQL---IHENELGAKL 643
            KD+ KK+ HN +ER+RR  IN +I++L  ++P    L  D++ NKG IL+ SV+YI  M              K +E  N QL   I E E+ A+L
Sbjct:  234 KDRQKKDNHNLIERRRRFNINDRIKELGTMIPKTNEL--DVRWNKGTILRASVDYIKRMQKDVERSKEVENNFKRMEMANKQLLLRIQELEMQARL 327

[Close]

BLAST of mitfl-3 protein vs. Ensembl Medaka
Match: MITF (microphthalmia-associated transcription factor [Source:NCBI gene;Acc:101165733])

HSP 1 Score: 53.1434 bits (126), Expect = 4.746e-7
Identity = 29/71 (40.85%), Postives = 46/71 (64.79%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL 613
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q   +L
Sbjct:  263 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQRAKEL 331

[Close]

BLAST of mitfl-3 protein vs. Ensembl Medaka
Match: MITF (microphthalmia-associated transcription factor [Source:NCBI gene;Acc:101165733])

HSP 1 Score: 53.1434 bits (126), Expect = 5.032e-7
Identity = 29/71 (40.85%), Postives = 46/71 (64.79%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL 613
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q   +L
Sbjct:  293 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQRAKEL 361

[Close]

BLAST of mitfl-3 protein vs. Ensembl Medaka
Match: MITF (microphthalmia-associated transcription factor [Source:NCBI gene;Acc:101165733])

HSP 1 Score: 52.7582 bits (125), Expect = 5.501e-7
Identity = 29/71 (40.85%), Postives = 46/71 (64.79%), Query Frame = 2

Query:  401 LIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQL 613
            L K++ KK+ HN +ER+RR  IN +I++L  L+P     + D++ NKG ILK SV+YI  ++  +Q   +L
Sbjct:  192 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSN--DPDMRWNKGTILKASVDYIRKLQREQQRAKEL 260

[Close]

BLAST of mitfl-3 protein vs. Planmine SMEST
Match: SMESG000009137.1 (SMESG000009137.1)

HSP 1 Score: 833.173 bits (2151), Expect = 0.000e+0
Identity = 414/433 (95.61%), Postives = 415/433 (95.84%), Query Frame = 2

Query:  131 MDALFSSKMNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSNVQLISDKSSPVLNGLLKKSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNVDSIKECKFFYSKEKTYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL 1429
            MDALF+SKMNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSN                 KSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASN DSIKECKFFYSKEKTYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL
Sbjct:    1 MDALFTSKMNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSN-----------------KSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNADSIKECKFFYSKEKTYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL 416

[Close]

BLAST of mitfl-3 protein vs. Planmine SMEST
Match: SMESG000009137.1 (SMESG000009137.1)

HSP 1 Score: 816.224 bits (2107), Expect = 0.000e+0
Identity = 407/425 (95.76%), Postives = 407/425 (95.76%), Query Frame = 2

Query:  155 MNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSNVQLISDKSSPVLNGLLKKSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNVDSIKECKFFYSKEKTYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL 1429
            MNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSN                 KSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASN DSIKECKFFYSKEKTYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL
Sbjct:    1 MNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVFNSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGNEEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMENVFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSN-----------------KSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQNLNTDNALIIDASNADSIKECKFFYSKEKTYYILPKPINSNFTTQLDENAVENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL 408

[Close]

BLAST of mitfl-3 protein vs. Planmine SMEST
Match: SMESG000077129.1 (SMESG000077129.1)

HSP 1 Score: 91.6633 bits (226), Expect = 3.586e-19
Identity = 57/138 (41.30%), Postives = 85/138 (61.59%), Query Frame = 2

Query:  398 QLIKDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINEN-LNYGAGNEEPDIGILINQWYAIHQDNKQLLQQF 808
            Q ++D++KK+ HNR+ERKRRD+IN QIQ+L +LLP + FL+ + K NKG ILKNSV YI   +L E I+   I   +  A++  +LI+  Y  +   Q  +  N +NY     + +   L+ +W+ IHQ N  LLQ+ 
Sbjct:  231 QWVRDRNKKDCHNRIERKRRDYINNQIQELGQLLPEKLFLSTESKRNKGGILKNSVIYI--QQLQESIS--CIQHLQKEAQISENLITVFYKHIQYLQDLLKSNGVNYEQNINDKN---LLQEWFDIHQTNSHLLQKI 361

[Close]

BLAST of mitfl-3 protein vs. Planmine SMEST
Match: SMESG000051880.1 (SMESG000051880.1)

HSP 1 Score: 77.411 bits (189), Expect = 7.228e-15
Identity = 36/60 (60.00%), Postives = 49/60 (81.67%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMK 586
            KD++KKE+HNR+ERKRRD+IN QI +L +L+P+E   + + K NKG ILKNSVEY+T +K
Sbjct:  196 KDRNKKESHNRIERKRRDYINHQITELGKLIPSEMNSDNESKKNKGNILKNSVEYVTRLK 255

[Close]

BLAST of mitfl-3 protein vs. Planmine SMEST
Match: SMESG000051880.1 (SMESG000051880.1)

HSP 1 Score: 77.411 bits (189), Expect = 8.430e-15
Identity = 36/60 (60.00%), Postives = 49/60 (81.67%), Query Frame = 2

Query:  407 KDKHKKETHNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITSMK 586
            KD++KKE+HNR+ERKRRD+IN QI +L +L+P+E   + + K NKG ILKNSVEY+T +K
Sbjct:  209 KDRNKKESHNRIERKRRDYINHQITELGKLIPSEMNSDNESKKNKGNILKNSVEYVTRLK 268

The following BLAST results are available for this feature:

BLAST of mitfl-3 protein vs. Ensembl Human
BLAST of mitfl-3 protein vs. Ensembl Celegans
BLAST of mitfl-3 protein vs. Ensembl Fly
BLAST of mitfl-3 protein vs. Ensembl Zebrafish
BLAST of mitfl-3 protein vs. Ensembl Xenopus
BLAST of mitfl-3 protein vs. Ensembl Mouse
BLAST of mitfl-3 protein vs. UniProt/SwissProt
BLAST of mitfl-3 protein vs. TrEMBL
BLAST of mitfl-3 protein vs. Ensembl Cavefish
BLAST of mitfl-3 protein vs. Ensembl Sea Lamprey
BLAST of mitfl-3 protein vs. Ensembl Yeast
BLAST of mitfl-3 protein vs. Ensembl Nematostella
BLAST of mitfl-3 protein vs. Ensembl Medaka
BLAST of mitfl-3 protein vs. Planmine SMEST

BLAST of mitfl-3 protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TFEB	3.119e-8	33.62	transcription factor EB [Source:HGNC Symbol;Acc:HG...	[more]
TFEB	3.577e-8	33.62	transcription factor EB [Source:HGNC Symbol;Acc:HG...	[more]
TFEB	3.878e-8	33.62	transcription factor EB [Source:HGNC Symbol;Acc:HG...	[more]
TFEB	4.428e-8	33.62	transcription factor EB [Source:HGNC Symbol;Acc:HG...	[more]
TFEB	4.428e-8	33.62	transcription factor EB [Source:HGNC Symbol;Acc:HG...	[more]

BLAST of mitfl-3 protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hlh-30	6.293e-8	46.43	Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86...	[more]
hlh-30	6.354e-8	46.43	Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86...	[more]
hlh-30	6.881e-8	46.43	Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86...	[more]
hlh-30	6.881e-8	46.43	Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86...	[more]
hlh-30	7.239e-8	46.43	Helix Loop Helix [Source:UniProtKB/TrEMBL;Acc:Q86...	[more]

BLAST of mitfl-3 protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Mitf	1.012e-8	47.06	gene:FBgn0263112 transcript:FBtr0307326	[more]
Mitf	1.012e-8	47.06	gene:FBgn0263112 transcript:FBtr0307327	[more]
Mitf	1.057e-8	47.06	gene:FBgn0263112 transcript:FBtr0307329	[more]
Mitf	1.146e-8	47.06	gene:FBgn0263112 transcript:FBtr0307328	[more]

BLAST of mitfl-3 protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mitfa	2.525e-7	38.96	melanocyte inducing transcription factor a [Source...	[more]
tfe3a	3.868e-7	36.73	transcription factor binding to IGHM enhancer 3a [...	[more]
mitfa	4.271e-7	40.85	melanocyte inducing transcription factor a [Source...	[more]
tfe3a	5.288e-7	38.03	transcription factor binding to IGHM enhancer 3a [...	[more]
mitfb	5.788e-7	27.18	melanocyte inducing transcription factor b [Source...	[more]

BLAST of mitfl-3 protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tfeb	5.977e-9	40.74	transcription factor EB [Source:NCBI gene;Acc:7801...	[more]
ipo9	8.318e-7	42.42	importin 9 [Source:Xenbase;Acc:XB-GENE-5960761]	[more]
ipo9	9.458e-7	42.42	importin 9 [Source:Xenbase;Acc:XB-GENE-5960761]	[more]
ipo9	1.048e-6	42.42	importin 9 [Source:Xenbase;Acc:XB-GENE-5960761]	[more]
ipo9	1.065e-6	42.42	importin 9 [Source:Xenbase;Acc:XB-GENE-5960761]	[more]

BLAST of mitfl-3 protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tfeb	3.597e-8	33.62	transcription factor EB [Source:MGI Symbol;Acc:MGI...	[more]
Tfeb	3.942e-8	33.62	transcription factor EB [Source:MGI Symbol;Acc:MGI...	[more]
Tfeb	3.942e-8	33.62	transcription factor EB [Source:MGI Symbol;Acc:MGI...	[more]
Tfeb	4.996e-8	33.62	transcription factor EB [Source:MGI Symbol;Acc:MGI...	[more]
Tfe3	2.110e-7	33.85	transcription factor E3 [Source:MGI Symbol;Acc:MGI...	[more]

BLAST of mitfl-3 protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P19484\|TFEB_HUMAN	2.126e-7	33.62	Transcription factor EB OS=Homo sapiens OX=9606 GN...	[more]
sp\|P19532\|TFE3_HUMAN	2.439e-7	32.61	Transcription factor E3 OS=Homo sapiens OX=9606 GN...	[more]
sp\|Q9R210\|TFEB_MOUSE	2.758e-7	33.62	Transcription factor EB OS=Mus musculus OX=10090 G...	[more]
sp\|P49379\|CBF1_KLULA	5.934e-7	37.21	Centromere-binding protein 1 OS=Kluyveromyces lact...	[more]
sp\|Q05B92\|TFE3_BOVIN	1.284e-6	31.85	Transcription factor E3 OS=Bos taurus OX=9913 GN=T...	[more]

BLAST of mitfl-3 protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
U5YTC8	0.000e+0	98.28	Mitfl-3 protein (Fragment) OS=Schmidtea mediterran...	[more]
A0A068WCM7	5.268e-16	40.46	Microphthalmia associated transcription factor OS=...	[more]
A0A4S2M3M1	5.931e-16	39.69	BHLH domain-containing protein OS=Opisthorchis fel...	[more]
G7Y7J8	6.306e-16	39.69	Transcription factor EB OS=Clonorchis sinensis OX=...	[more]
A0A3R7CHW0	6.417e-16	39.69	Transcription factor EB OS=Clonorchis sinensis OX=...	[more]

BLAST of mitfl-3 protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mitfa	1.315e-7	40.91	melanocyte inducing transcription factor a [Source...	[more]
tfeb	2.319e-7	37.76	transcription factor EB [Source:NCBI gene;Acc:1030...	[more]
tfe3b	2.583e-7	34.88	transcription factor binding to IGHM enhancer 3b [...	[more]
tfeb	2.738e-7	37.76	transcription factor EB [Source:NCBI gene;Acc:1030...	[more]
tfe3a	3.425e-7	46.55	transcription factor E3 [Source:NCBI gene;Acc:1030...	[more]

BLAST of mitfl-3 protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
mitfa	1.226e-9	32.87	melanocyte inducing transcription factor a [Source...	[more]
ENSPMAT00000009530.1	8.738e-9	43.55	pep scaffold:Pmarinus_7.0:GL478885:25441:30908:1 g...	[more]
ENSPMAT00000001124.1	2.264e-8	42.42	pep scaffold:Pmarinus_7.0:GL489212:1887:7231:1 gen...	[more]
ENSPMAT00000001122.1	3.819e-8	42.42	pep scaffold:Pmarinus_7.0:GL489212:1806:7231:1 gen...	[more]

BLAST of mitfl-3 protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
RTG3	5.608e-8	37.68	bHLH/Zip transcription factor for retrograde (RTG)...	[more]

BLAST of mitfl-3 protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO39334	1.079e-9	33.03	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44411	1.431e-9	42.50	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO28110	2.170e-8	39.02	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of mitfl-3 protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tfe3b	1.560e-7	36.73	transcription factor binding to IGHM enhancer 3 [S...	[more]
tfeb	1.745e-7	38.54	transcription factor EB [Source:NCBI gene;Acc:1011...	[more]
MITF	4.746e-7	40.85	microphthalmia-associated transcription factor [So...	[more]
MITF	5.032e-7	40.85	microphthalmia-associated transcription factor [So...	[more]
MITF	5.501e-7	40.85	microphthalmia-associated transcription factor [So...	[more]

BLAST of mitfl-3 protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000009137.1	0.000e+0	95.61	SMESG000009137.1	[more]
SMESG000009137.1	0.000e+0	95.76	SMESG000009137.1	[more]
SMESG000077129.1	3.586e-19	41.30	SMESG000077129.1	[more]
SMESG000051880.1	7.228e-15	60.00	SMESG000051880.1	[more]
SMESG000051880.1	8.430e-15	60.00	SMESG000051880.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30003618
GenBank	AGZ94934.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30003618 ID=SMED30003618|Name=mitfl-3 protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1733bp
AGATGCTTCTAAATTACATTTGATTTTTGTTGAAATTTTTATATTTGTGT
TTGTCAAAATTTTATAATTCATATTTTTGTTTGCTGACATTTAAATGATT
TAAAGTTAATTTTATGAAATATTGTATTGCATGGATGCGTTGTTTTCTTC
AAAGATGAATACAAAATCTGGTAATGATAAAATAAAAATTCTTAAACTTG
AATCGTTTTCTAATCCTCAATTAAAACGACGACGATCACACAGTCACAAT
GGTGCTGAATTATCAAACAACAAAGTTTTCAACTCAAATGGAAGTGGTTG
TCAGTTATTTTTGTCTGCACACAAAGAATCTTCCCCTATAGATAATTCTC
AACTAAAACCAATTATAAATAATTGCCATTCACCTTTTGTAAACAATCAA
TTAATCAAAGATAAACACAAGAAAGAAACTCACAATCGTGTTGAAAGGAA
AAGACGGGATTTTATTAATTGCCAAATTCAAAAATTAGCTGAGCTTTTGC
CAACGGAGTTCTTTCTTAACTGTGATCTTAAAATGAATAAAGGAGTGATT
TTAAAAAATTCAGTGGAATATATAACATCAATGAAATTAGTAGAGCAGAT
TAATCATCAATTAATTCATGAAAATGAATTAGGAGCAAAATTAATTCGCT
CTTTAATTAGTTCAAATTACACTGACCTTAATTGCTCGCAACTTTCAATT
AATGAAAACCTGAATTATGGTGCCGGCAACGAAGAACCCGATATTGGAAT
TCTCATCAACCAGTGGTATGCTATCCATCAAGATAATAAACAATTACTCC
AACAATTTACACAAAAAGTTTCCAATTCTTTACTAAATAAGGACAATTCT
AAAGAATTCGATGATATCATTATGGAAAACGTTTTTGTTAATGATTCTAG
AAATAACAATTCCACCATAAACCCTTCTATTCAATCTAGAAAACGGTATT
CTTCTCTTCCAACTGATATCAGTCCTGAAATTCAGTTGCAAAGATGTCAA
AACTCAAATGTACAGTTAATATCTGATAAGTCTTCTCCAGTTTTAAATGG
TTTATTGAAGAAATCAAATGATCACAATTTTACGCACAACGAAGCGTTGG
AACAGATTTATCGAATTGATTCTAATGACGATGGAGTGGACTTCTATCTT
CGCTACTCTGCCAGTCCGGTCGTCGGTCAGAATCTCAACACAGATAACGC
CTTAATCATTGATGCGTCAAATGTAGATTCTATTAAAGAATGCAAATTTT
TCTATTCTAAAGAAAAAACGTATTATATATTGCCAAAACCAATTAATTCA
AATTTCACGACCCAGTTGGATGAAAATGCTGTAGAGAATTGCAGTGATAA
ATTGAACCCAATCGATCCTAGTGAAGGATTCAACAAGTCAAATGATCCAA
TGCTTCTGTCGAGTAGTCCAACGCATCTTTAACCACATTTTTTGATATGT
CAATTTTGTCATATTACTATATCACTATCCTAATTTCAAGTTTCACTGAA
ACATAATCAAATTGAGCCATTTTATTTGTCCGTTTTCAAGGAGAATTGTG
CTAAAGAAAATTCCAATATTTTGTTTAATTATAAATGTAATAGTTGTCTT
TCTTGGATTTTTAATAATGTTTACTGAGAAATCTCTGATTTTCCAGATAT
AAATATTTATGTATTTTTTATGTATTTACCGGAGAAGAATATAAGTAATT
ATTATTAATGATATTTTAATTATTATAATTGAT

protein sequence of SMED30003618-orf-1

>SMED30003618-orf-1 ID=SMED30003618-orf-1|Name=SMED30003618-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=434bp
MDALFSSKMNTKSGNDKIKILKLESFSNPQLKRRRSHSHNGAELSNNKVF
NSNGSGCQLFLSAHKESSPIDNSQLKPIINNCHSPFVNNQLIKDKHKKET
HNRVERKRRDFINCQIQKLAELLPTEFFLNCDLKMNKGVILKNSVEYITS
MKLVEQINHQLIHENELGAKLIRSLISSNYTDLNCSQLSINENLNYGAGN
EEPDIGILINQWYAIHQDNKQLLQQFTQKVSNSLLNKDNSKEFDDIIMEN
VFVNDSRNNNSTINPSIQSRKRYSSLPTDISPEIQLQRCQNSNVQLISDK
SSPVLNGLLKKSNDHNFTHNEALEQIYRIDSNDDGVDFYLRYSASPVVGQ
NLNTDNALIIDASNVDSIKECKFFYSKEKTYYILPKPINSNFTTQLDENA
VENCSDKLNPIDPSEGFNKSNDPMLLSSSPTHL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000103	central nervous system
PLANA:0000120	progenitor cell
PLANA:0000121	stem cell
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR036638	HLH_DNA-bd_sf
IPR011598	bHLH_dom

Vocabulary: **molecular function**
Term	Definition
GO:0046983	protein dimerization activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	SMART	SM00353	finulus	coord: 102..157 e-value: 1.8E-8 score: 44.1
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	PFAM	PF00010	HLH	coord: 97..151 e-value: 3.8E-12 score: 46.0
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	PROSITE	PS50888	BHLH	coord: 96..151 score: 13.122
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	CDD	cd00083	HLH	coord: 94..156 e-value: 7.06134E-10 score: 52.6015
IPR036638	Helix-loop-helix DNA-binding domain superfamily	GENE3D	G3DSA:4.10.280.10		coord: 92..163 e-value: 2.3E-17 score: 64.4
IPR036638	Helix-loop-helix DNA-binding domain superfamily	SUPERFAMILY	SSF47459	HLH, helix-loop-helix DNA-binding domain	coord: 94..152
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 410..433
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 414..433
None	No IPR available	PANTHER	PTHR46117:SF3	FI24210P1	coord: 66..319
None	No IPR available	PANTHER	PTHR46117	FAMILY NOT NAMED	coord: 66..319