Amyloid beta (A4) precursor protein b

Overview


Name	Amyloid beta (A4) precursor protein b
Smed ID	SMED30003584
Length (bp)	1718

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Amyloid beta (A4) precursor protein b (SMED30003584) t-SNE clustered cells

Violin plots show distribution of expression levels for Amyloid beta (A4) precursor protein b (SMED30003584) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Amyloid beta (A4) precursor protein b (SMED30003584) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Amyloid beta (A4) precursor protein b (SMED30003584) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30003584

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
posterior side	SMED30003584	SMESG000057580.1	dd_Smed_v4_5336_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30003584	SMESG000057580.1	dd_Smed_v4_5336_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
Match: APP (amyloid beta precursor protein [Source:HGNC Symbol;Acc:HGNC:620])

HSP 1 Score: 72.0182 bits (175), Expect = 1.662e-12
Identity = 43/123 (34.96%), Postives = 60/123 (48.78%), Query Frame = 2

Query:  203 ILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +   + V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   34 ILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 153

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
Match: APP (amyloid beta precursor protein [Source:HGNC Symbol;Acc:HGNC:620])

HSP 1 Score: 72.0182 bits (175), Expect = 1.724e-12
Identity = 43/123 (34.96%), Postives = 60/123 (48.78%), Query Frame = 2

Query:  203 ILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +   + V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   69 ILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
Match: APP (amyloid beta precursor protein [Source:HGNC Symbol;Acc:HGNC:620])

HSP 1 Score: 72.0182 bits (175), Expect = 1.876e-12
Identity = 44/129 (34.11%), Postives = 61/129 (47.29%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +   + V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
Match: APP (amyloid beta precursor protein [Source:HGNC Symbol;Acc:HGNC:620])

HSP 1 Score: 71.633 bits (174), Expect = 1.883e-12
Identity = 44/129 (34.11%), Postives = 61/129 (47.29%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +   + V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   58 IDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 183

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
Match: APP (amyloid beta precursor protein [Source:HGNC Symbol;Acc:HGNC:620])

HSP 1 Score: 71.633 bits (174), Expect = 2.147e-12
Identity = 44/129 (34.11%), Postives = 61/129 (47.29%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +   + V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Celegans
Match: apl-1 (Amyloid-beta-like protein [Source:UniProtKB/Swiss-Prot;Acc:Q10651])

HSP 1 Score: 79.337 bits (194), Expect = 2.560e-15
Identity = 51/173 (29.48%), Postives = 87/173 (50.29%), Query Frame = 2

Query:   92 HLQFIPSISYHAGSSIMYKTDKG-WILNEN---ITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWC-HGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQT-LENRPECLSFDTWKNISVTLCSESYSYV-VDMIQYS-----PCTDKVMIFSKVDIICCPADK 574
            H +FIP +++  G    Y T++G W  ++           DILK C+  YP+ NITN+++     +I++WC   G  C    ++ V P+ C++     E  +VP +CQ + + +R +C  +  WK+ +   C    S    DMI  S     PC   + +F+ V+ +CCP D+
Sbjct:   31 HEKFIPMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPC--KWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCA--LDMFTGVEFVCCPNDQ 199

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Celegans
Match: apl-1 (Amyloid-beta-like protein [Source:UniProtKB/Swiss-Prot;Acc:Q10651])

HSP 1 Score: 79.337 bits (194), Expect = 2.704e-15
Identity = 51/173 (29.48%), Postives = 87/173 (50.29%), Query Frame = 2

Query:   92 HLQFIPSISYHAGSSIMYKTDKG-WILNEN---ITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWC-HGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQT-LENRPECLSFDTWKNISVTLCSESYSYV-VDMIQYS-----PCTDKVMIFSKVDIICCPADK 574
            H +FIP +++  G    Y T++G W  ++           DILK C+  YP+ NITN+++     +I++WC   G  C    ++ V P+ C++     E  +VP +CQ + + +R +C  +  WK+ +   C    S    DMI  S     PC   + +F+ V+ +CCP D+
Sbjct:   31 HEKFIPMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPC--KWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCA--LDMFTGVEFVCCPNDQ 199

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
Match: Appl (gene:FBgn0000108 transcript:FBtr0307293)

HSP 1 Score: 71.2478 bits (173), Expect = 1.497e-12
Identity = 36/132 (27.27%), Postives = 56/132 (42.42%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGG----RNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            ++   D+L  C+  YPN +ITN+++    + I  WC  G      C  +  + + PFRCL    + +   VP  C    + N   C  F  W       C E    +       PC   + +FS V+ +CCP
Sbjct:   71 LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRW-IKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCG--ISVFSGVEFVCCP 199

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
Match: Appl (gene:FBgn0000108 transcript:FBtr0307295)

HSP 1 Score: 71.2478 bits (173), Expect = 1.632e-12
Identity = 36/132 (27.27%), Postives = 56/132 (42.42%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGG----RNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            ++   D+L  C+  YPN +ITN+++    + I  WC  G      C  +  + + PFRCL    + +   VP  C    + N   C  F  W       C E    +       PC   + +FS V+ +CCP
Sbjct:   71 LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRW-IKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCG--ISVFSGVEFVCCP 199

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
Match: Appl (gene:FBgn0000108 transcript:FBtr0070109)

HSP 1 Score: 66.6254 bits (161), Expect = 4.087e-11
Identity = 36/132 (27.27%), Postives = 56/132 (42.42%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGG----RNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            ++   D+L  C+  YPN +ITN+++    + I  WC  G      C  +  + + PFRCL    + +   VP  C    + N   C  F  W       C E    +       PC   + +FS V+ +CCP
Sbjct:   71 LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRW-IKPFRCLG-PFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCG--ISVFSGVEFVCCP 198

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
Match: Appl (gene:FBgn0000108 transcript:FBtr0307294)

HSP 1 Score: 66.6254 bits (161), Expect = 4.115e-11
Identity = 36/132 (27.27%), Postives = 56/132 (42.42%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGG----RNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            ++   D+L  C+  YPN +ITN+++    + I  WC  G      C  +  + + PFRCL    + +   VP  C    + N   C  F  W       C E    +       PC   + +FS V+ +CCP
Sbjct:   71 LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRW-IKPFRCLG-PFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCG--ISVFSGVEFVCCP 198

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
Match: Appl (gene:FBgn0000108 transcript:FBtr0307291)

HSP 1 Score: 66.6254 bits (161), Expect = 4.273e-11
Identity = 36/132 (27.27%), Postives = 56/132 (42.42%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGG----RNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            ++   D+L  C+  YPN +ITN+++    + I  WC  G      C  +  + + PFRCL    + +   VP  C    + N   C  F  W       C E    +       PC   + +FS V+ +CCP
Sbjct:   71 LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRW-IKPFRCLG-PFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCG--ISVFSGVEFVCCP 198

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 70.4774 bits (171), Expect = 2.772e-12
Identity = 41/132 (31.06%), Postives = 64/132 (48.48%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+ ++ V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   65 ISTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCG--IDRFRGVEFVCCPMEEQ 194

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 70.4774 bits (171), Expect = 3.374e-12
Identity = 41/132 (31.06%), Postives = 64/132 (48.48%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+ ++ V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   54 ISTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCG--IDRFRGVEFVCCPMEEQ 183

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 70.4774 bits (171), Expect = 3.379e-12
Identity = 41/132 (31.06%), Postives = 64/132 (48.48%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+ ++ V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   54 ISTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCG--IDRFRGVEFVCCPMEEQ 183

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 70.4774 bits (171), Expect = 3.430e-12
Identity = 41/132 (31.06%), Postives = 64/132 (48.48%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+ ++ V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   53 ISTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCG--IDRFRGVEFVCCPMEEQ 182

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 70.4774 bits (171), Expect = 3.432e-12
Identity = 41/132 (31.06%), Postives = 64/132 (48.48%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+ ++ V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   65 ISTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCG--IDRFRGVEFVCCPMEEQ 194

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
Match: gtf2e2 (general transcription factor IIE subunit 2 [Source:Xenbase;Acc:XB-GENE-962385])

HSP 1 Score: 70.4774 bits (171), Expect = 4.163e-12
Identity = 43/129 (33.33%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   ++ ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE    + +     PC  DK   F  V+ +CCP
Sbjct:   62 IGTKEGILQYCQDVYPELQITNVVEANQPVTIQNWCKRGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDK---FRGVEFVCCP 187

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
Match: gtf2e2 (general transcription factor IIE subunit 2 [Source:Xenbase;Acc:XB-GENE-962385])

HSP 1 Score: 70.4774 bits (171), Expect = 4.560e-12
Identity = 43/129 (33.33%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   ++ ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE    + +     PC  DK   F  V+ +CCP
Sbjct:   52 IGTKEGILQYCQDVYPELQITNVVEANQPVTIQNWCKRGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDK---FRGVEFVCCP 177

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
Match: gtf2e2 (general transcription factor IIE subunit 2 [Source:Xenbase;Acc:XB-GENE-962385])

HSP 1 Score: 70.4774 bits (171), Expect = 4.799e-12
Identity = 43/129 (33.33%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   ++ ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE    + +     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQDVYPELQITNVVEANQPVTIQNWCKRGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
Match: gtf2e2 (general transcription factor IIE subunit 2 [Source:Xenbase;Acc:XB-GENE-962385])

HSP 1 Score: 70.4774 bits (171), Expect = 4.925e-12
Identity = 43/129 (33.33%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   ++ ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE    + +     PC  DK   F  V+ +CCP
Sbjct:   28 IGTKEGILQYCQDVYPELQITNVVEANQPVTIQNWCKRGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDK---FRGVEFVCCP 153

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
Match: gtf2e2 (general transcription factor IIE subunit 2 [Source:Xenbase;Acc:XB-GENE-962385])

HSP 1 Score: 70.0922 bits (170), Expect = 5.406e-12
Identity = 43/129 (33.33%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   ++ ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE    + +     PC  DK   F  V+ +CCP
Sbjct:   28 IGTKEGILQYCQDVYPELQITNVVEANQPVTIQNWCKRGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDK---FRGVEFVCCP 153

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
Match: App (amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059])

HSP 1 Score: 72.7886 bits (177), Expect = 6.499e-13
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
Match: App (amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059])

HSP 1 Score: 72.7886 bits (177), Expect = 6.558e-13
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
Match: App (amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059])

HSP 1 Score: 72.7886 bits (177), Expect = 7.266e-13
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
Match: App (amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059])

HSP 1 Score: 72.4034 bits (176), Expect = 7.516e-13
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
Match: App (amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059])

HSP 1 Score: 72.4034 bits (176), Expect = 8.319e-13
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
Match: sp|Q06BR2|A4_DORPE (Amyloid-beta precursor-like protein OS=Doryteuthis pealeii OX=1051067 PE=1 SV=2)

HSP 1 Score: 80.8777 bits (198), Expect = 1.257e-14
Identity = 47/163 (28.83%), Postives = 80/163 (49.08%), Query Frame = 2

Query:   98 QFIPSISYHAGSSIMYKTDKGWILNENIT---IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRN---CTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            +F P +++      M++   GW+ +++     +K   +IL+ C+ +YP+++ITNV++     TI NWC  G N   C ++ ++ V PFRCL    + E   VP +C     + P  C  FD     +++ CS             PC +    FS V+ +CCP
Sbjct:   29 KFEPMVAFICNKPAMHRVPSGWVPDDDPAKSCVKQPEEILEYCKKLYPDHDITNVLQASYKVTIPNWC--GFNVTHCHKHGNHTVRPFRCLVGPFQSEALLVPEHCIFDHYHDPRVCNEFDQCNETAMSKCSARGMTTQSFAMLWPCQEPGH-FSGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
Match: sp|Q10651|A4_CAEEL (Amyloid-beta-like protein OS=Caenorhabditis elegans OX=6239 GN=apl-1 PE=1 SV=2)

HSP 1 Score: 79.337 bits (194), Expect = 3.439e-14
Identity = 51/173 (29.48%), Postives = 87/173 (50.29%), Query Frame = 2

Query:   92 HLQFIPSISYHAGSSIMYKTDKG-WILNEN---ITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWC-HGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQT-LENRPECLSFDTWKNISVTLCSESYSYV-VDMIQYS-----PCTDKVMIFSKVDIICCPADK 574
            H +FIP +++  G    Y T++G W  ++           DILK C+  YP+ NITN+++     +I++WC   G  C    ++ V P+ C++     E  +VP +CQ + + +R +C  +  WK+ +   C    S    DMI  S     PC   + +F+ V+ +CCP D+
Sbjct:   31 HEKFIPMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPC--KWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCA--LDMFTGVEFVCCPNDQ 199

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
Match: sp|P08592|A4_RAT (Amyloid-beta A4 protein OS=Rattus norvegicus OX=10116 GN=App PE=1 SV=2)

HSP 1 Score: 72.4034 bits (176), Expect = 5.477e-12
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
Match: sp|P12023|A4_MOUSE (Amyloid-beta A4 protein OS=Mus musculus OX=10090 GN=App PE=1 SV=3)

HSP 1 Score: 72.4034 bits (176), Expect = 5.819e-12
Identity = 44/129 (34.11%), Postives = 62/129 (48.06%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +  ++ V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
Match: sp|Q5IS80|A4_PANTR (Amyloid-beta A4 protein OS=Pan troglodytes OX=9598 GN=APP PE=2 SV=1)

HSP 1 Score: 71.633 bits (174), Expect = 9.873e-12
Identity = 44/129 (34.11%), Postives = 61/129 (47.29%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCT-DKVMIFSKVDIICCP 565
            I     IL+ CQ VYP   ITNV++  Q  TI NWC  GR   +   + V P+RCL      +   VP  C+   + R + C +   W  ++   CSE  + + D     PC  DK   F  V+ +CCP
Sbjct:   63 IDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDK---FRGVEFVCCP 188

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
Match: A0A1S3JZF2 (amyloid-beta-like protein OS=Lingula unguis OX=7574 GN=LOC106177438 PE=4 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 4.821e-16
Identity = 49/160 (30.63%), Postives = 81/160 (50.62%), Query Frame = 2

Query:  107 PSISYHAGSSIMYKTDKGWILNENIT-IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGG-RNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            P +++    + MYKT KGW+ + +   +K    I++ C+ VYP  +ITNV++     TI  WC  G + C  + S+ V PF+CL      +   VP +C  Q +  + +CL+F+ W   + + C E            PC   + +F+ V+ +CCP D K
Sbjct:   42 PMVAFLCNKAAMYKTKKGWVADRDTDCLKDGSQIVEFCKKVYPKLDITNVVEASDEVTIDGWCKKGHKTCKHHSSHKVRPFKCLVGKFVSDALLVPEHCVFQHIRVKEKCLTFNDWTYEANSWCEEKGMQRQSSAMLLPCG--IDVFTGVEFVCCPKDNK 199

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
Match: A0A067QLF7 (Beta-amyloid-like protein (Fragment) OS=Zootermopsis nevadensis OX=136037 GN=L798_00553 PE=4 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 2.119e-13
Identity = 48/167 (28.74%), Postives = 81/167 (48.50%), Query Frame = 2

Query:  101 FIPSISYHAGSS------IMYKTDKG-WIL---NENITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCH-GGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            F P ++ + GS         Y T+ G W+    N+ + +K   +IL+ C+ VYP  +ITN+++    + ++NWC  G + C  + S  V P+RCL    + +   VP NC    + N+ +C  FD W   +   C +    +       PC   + +FS V+ +CCP
Sbjct:    8 FEPQVAMYCGSDKQQAYHSQYMTESGHWVTDLNNKALCLKEKVEILEYCKKVYPKRDITNIVEASHYQKVSNWCKVGHKKCKGSHSEWVKPYRCLEGPFQSDALLVPENCLFDHIHNQTKCWQFDRWNVTAAQACLDRDLSLRSFAMLLPCG--ISLFSGVEFVCCP 172

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
Match: A0A2A6B2I0 (Apl-1 OS=Pristionchus pacificus OX=54126 GN=PRIPAC_49357 PE=4 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 2.999e-13
Identity = 51/172 (29.65%), Postives = 87/172 (50.58%), Query Frame = 2

Query:   92 HLQFIPSISYHAGSSIMYKTDKG-WILNEN---ITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWC-HGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLEN-RPECLSFDTWKNISVTLCSESYS------YVVDMIQYSPCTDKVMIFSKVDIICCPAD 571
            H +F+P I++  G    Y  + G W+ ++N     ++ + D LK C+ VYPN N+TN+++     T+ +WC   G +CT   +  V P+RC+      E  +VP +C+   EN + +C  + +WKN +  LC+           V       PC   + +F+ V+ +CCP D
Sbjct:  296 HERFVPLIAFKCGFRNRYMAENGSWVSDDNKYATCLEGNLDKLKYCKKVYPNLNVTNIVEYSHEVTLADWCREEGDHCTSTKT--VRPYRCIVGEFHSEALQVPHDCRFNHENSQQKCNDYTSWKNEATRLCNSRKDEGGRAMIVRSFAMLEPCG--LDLFTGVEYVCCPTD 463

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
Match: H3FMK4 (Apl-1 OS=Pristionchus pacificus OX=54126 GN=WBGene00113065 PE=4 SV=2)

HSP 1 Score: 84.7297 bits (208), Expect = 2.999e-13
Identity = 51/172 (29.65%), Postives = 87/172 (50.58%), Query Frame = 2

Query:   92 HLQFIPSISYHAGSSIMYKTDKG-WILNEN---ITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWC-HGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLEN-RPECLSFDTWKNISVTLCSESYS------YVVDMIQYSPCTDKVMIFSKVDIICCPAD 571
            H +F+P I++  G    Y  + G W+ ++N     ++ + D LK C+ VYPN N+TN+++     T+ +WC   G +CT   +  V P+RC+      E  +VP +C+   EN + +C  + +WKN +  LC+           V       PC   + +F+ V+ +CCP D
Sbjct:  296 HERFVPLIAFKCGFRNRYMAENGSWVSDDNKYATCLEGNLDKLKYCKKVYPNLNVTNIVEYSHEVTLADWCREEGDHCTSTKT--VRPYRCIVGEFHSEALQVPHDCRFNHENSQQKCNDYTSWKNEATRLCNSRKDEGGRAMIVRSFAMLEPCG--LDLFTGVEYVCCPTD 463

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
Match: A0A0K2UWH1 (Betaamyloidlike proteinlike [Bombus terrestris] OS=Lepeophtheirus salmonis OX=72036 PE=4 SV=1)

HSP 1 Score: 84.3445 bits (207), Expect = 3.177e-13
Identity = 40/123 (32.52%), Postives = 65/123 (52.85%), Query Frame = 2

Query:  200 DILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCP 565
            +IL+ C+ VYP+ +I N+++ +    I NWC  GR   +  +  V P+RCL    + +   VP +C    + N+  CL+FDTW   + + CS+    V       PC   + +FS V+ +CCP
Sbjct:   57 EILEYCKKVYPDMDINNIVESFHWVKINNWCKLGRKKCKGPARWVKPYRCLAGPFQSDALLVPEHCLFDHIHNQTRCLAFDTWNVTAASACSDRGMKVKSFAMLLPCG--IDVFSGVEFVCCP 177

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
Match: ENSAMXT00000015571.2 (pep primary_assembly:Astyanax_mexicanus-2.0:12:31369849:31402293:1 gene:ENSAMXG00000015133.2 transcript:ENSAMXT00000015571.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 72.0182 bits (175), Expect = 6.971e-13
Identity = 45/141 (31.91%), Postives = 66/141 (46.81%), Query Frame = 2

Query:  161 WILNENIT---IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPAD 571
            W L+ + T   I     IL+ CQ VYP   ITNV++  Q  +I NWC  GR   R+  + V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCPA+
Sbjct:   46 WELDPSGTKGCIGTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHVHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICESHLHWHTVAKESCGDHTMNLHDYGMLLPCG--IDRFRGVEFVCCPAE 184

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
Match: appb (amyloid beta A4 protein-like [Source:NCBI gene;Acc:103046668])

HSP 1 Score: 71.633 bits (174), Expect = 9.946e-13
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+  + V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   63 IGTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKKGRRQCRSHVHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDQTMNLHDFGMLLPCG--IDRFRGVEFVCCPVEEQ 192

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
Match: appb (amyloid beta A4 protein-like [Source:NCBI gene;Acc:103046668])

HSP 1 Score: 70.8626 bits (172), Expect = 2.242e-12
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+  + V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   64 IGTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKKGRRQCRSHVHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDQTMNLHDFGMLLPCG--IDRFRGVEFVCCPVEEQ 193

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
Match: appb (amyloid beta A4 protein-like [Source:NCBI gene;Acc:103046668])

HSP 1 Score: 70.4774 bits (171), Expect = 2.337e-12
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+  + V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   64 IGTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKKGRRQCRSHVHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDQTMNLHDFGMLLPCG--IDRFRGVEFVCCPVEEQ 193

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
Match: appb (amyloid beta A4 protein-like [Source:NCBI gene;Acc:103046668])

HSP 1 Score: 70.4774 bits (171), Expect = 2.523e-12
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPE-CLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     IL+ CQ VYP+  ITNV++  Q  +I NWC  GR   R+  + V P+RCL      +   VP  C+   + R + C S   W  ++   C +    + D     PC   +  F  V+ +CCP +++
Sbjct:   64 IGTKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKKGRRQCRSHVHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDQTMNLHDFGMLLPCG--IDRFRGVEFVCCPVEEQ 193

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Nematostella
Match: EDO45291 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTM2])

HSP 1 Score: 69.707 bits (169), Expect = 1.287e-12
Identity = 45/142 (31.69%), Postives = 66/142 (46.48%), Query Frame = 2

Query:  161 WILNEN---ITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQ-QTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADK 574
            W  +EN   +    +  +LK CQ VYP  N++NV++     TI  WC   +N   N +  V P+RCL    E +   VP  C+ Q L    EC S D WK  +   C +  + +       PC     +F+ V+ +CCP  K
Sbjct:   52 WATDENGHSMCSTSTKQVLKYCQHVYPKLNVSNVVEANMNVTIKTWC-DPKNVNCNATKTVLPYRCLVGKFEADALLVPPGCRFQHLHPGSECKSHDFWKIKAEEKCKDQDANLRYYGVLLPCN--TGLFTGVEFVCCPVKK 190

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
Match: appb (amyloid-beta A4 protein [Source:NCBI gene;Acc:101172288])

HSP 1 Score: 72.4034 bits (176), Expect = 6.903e-13
Identity = 42/132 (31.82%), Postives = 62/132 (46.97%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENR-PECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     +L+ CQ VYP   ITNV++  Q  +ITNWC  GR   R+  + V P+RCL      +   VP  C+   + R  +C S   W  ++   C +    + D     PC   V  F  V+ +CCP + +
Sbjct:   64 IDTKEGLLRYCQEVYPELQITNVVEANQPVSITNWCKKGRKQCRSHPHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDQCESHLHWHTVAKESCGDRSMNLHDYGMLLPCN--VDRFRGVEFVCCPVEGE 193

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
Match: appb (amyloid-beta A4 protein [Source:NCBI gene;Acc:101172288])

HSP 1 Score: 72.0182 bits (175), Expect = 8.213e-13
Identity = 42/132 (31.82%), Postives = 62/132 (46.97%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENR-PECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKK 577
            I     +L+ CQ VYP   ITNV++  Q  +ITNWC  GR   R+  + V P+RCL      +   VP  C+   + R  +C S   W  ++   C +    + D     PC   V  F  V+ +CCP + +
Sbjct:   64 IDTKEGLLRYCQEVYPELQITNVVEANQPVSITNWCKKGRKQCRSHPHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDQCESHLHWHTVAKESCGDRSMNLHDYGMLLPCN--VDRFRGVEFVCCPVEGE 193

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
Match: APP (amyloid-beta A4 protein [Source:NCBI gene;Acc:101162104])

HSP 1 Score: 68.9366 bits (167), Expect = 8.098e-12
Identity = 40/130 (30.77%), Postives = 59/130 (45.38%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENR-PECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPAD 571
            I     IL+ CQ VYP   ITNV++  Q  +I +WC  GR   R   + V P+RCL      +   VP  C+   + R  +C S   W  ++   C +    + D     PC   +  F  V+ +CCP +
Sbjct:   38 IGTKEGILQYCQEVYPELQITNVVEANQPVSIQSWCKKGRKQCRGHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDQCESHLHWHTVAKESCGDRTMTLHDYGMLLPCG--IDRFKGVEFVCCPTE 165

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
Match: APP (amyloid-beta A4 protein [Source:NCBI gene;Acc:101162104])

HSP 1 Score: 68.1662 bits (165), Expect = 1.526e-11
Identity = 40/130 (30.77%), Postives = 59/130 (45.38%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENR-PECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPAD 571
            I     IL+ CQ VYP   ITNV++  Q  +I +WC  GR   R   + V P+RCL      +   VP  C+   + R  +C S   W  ++   C +    + D     PC   +  F  V+ +CCP +
Sbjct:   64 IGTKEGILQYCQEVYPELQITNVVEANQPVSIQSWCKKGRKQCRGHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDQCESHLHWHTVAKESCGDRTMTLHDYGMLLPCG--IDRFKGVEFVCCPTE 191

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
Match: APP (amyloid-beta A4 protein [Source:NCBI gene;Acc:101162104])

HSP 1 Score: 68.1662 bits (165), Expect = 1.570e-11
Identity = 40/130 (30.77%), Postives = 59/130 (45.38%), Query Frame = 2

Query:  185 IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENR-PECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPAD 571
            I     IL+ CQ VYP   ITNV++  Q  +I +WC  GR   R   + V P+RCL      +   VP  C+   + R  +C S   W  ++   C +    + D     PC   +  F  V+ +CCP +
Sbjct:   64 IGTKEGILQYCQEVYPELQITNVVEANQPVSIQSWCKKGRKQCRGHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDQCESHLHWHTVAKESCGDRTMTLHDYGMLLPCG--IDRFKGVEFVCCPTE 191

[Close]

BLAST of Amyloid beta (A4) precursor protein b vs. Planmine SMEST
Match: SMESG000057580.1 (SMESG000057580.1)

HSP 1 Score: 859.751 bits (2220), Expect = 0.000e+0
Identity = 457/463 (98.70%), Postives = 461/463 (99.57%), Query Frame = 2

Query:  140 MYKTDKGWILNENITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHERETFKVPINCQQTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTDKVMIFSKVDIICCPADKKYYNSLLNTYLKGSHNERWIFSQXXXXXXXXXXXXXXXXGRDICAKQNLISMRHDKSSLKEDLENLKLEFQSNFSKNKKWFFEENLKIERTHIQRIFKKVNMSCKPPMTQHQLSICVKQINSTLVQLQNHYKRTSNIHFQDFKQYLIREFEILFQNYTNIFKTANLMTKLQSVRDYLTSAPVNLSYEDSSSKEYKRHILKCNSPISFDHPTSNSHATPIMSXXXXXXXXXXXXXXXXXXXXXXKFCGQPFHRSTPNYVMSVVFDANQTQGPMPQSDQNLSENSNKQNVKLTLYENPIFNAKSATKPIEKQSLIENMES 1528
            MYKTDKGWILNENITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHE+ETFKVPINCQQTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCT+KVM+FSKVDIICCPADKKYYNSLLNTYLKGSHNERWIFSQLRHALLLLYRVKLRNLGRDICAKQNLISMRHDKS LKEDLENLKLEFQSNFSKNKKWFFEENLKIERTHIQRIFKKVNMSCKPPMTQHQLSICVKQINSTLVQLQNHYKRTSNIHFQDFKQYLIREFEILFQNYTNIFKTANLMTKLQSVRDYLTSAPVNLSYEDSSSKEYKR ILKCNSPISFDHPTSNSHATPIMSIVVTTVILLILIILTFIGTIVIKFCGQPFHRSTPNYVMSVVFDANQTQGPMPQSDQNLSENSNKQNVKLTLYENPIF+AKSATKPIEKQSLIENMES
Sbjct:    1 MYKTDKGWILNENITIKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDVHPFRCLNSTHEKETFKVPINCQQTLENRPECLSFDTWKNISVTLCSESYSYVVDMIQYSPCTEKVMMFSKVDIICCPADKKYYNSLLNTYLKGSHNERWIFSQLRHALLLLYRVKLRNLGRDICAKQNLISMRHDKSYLKEDLENLKLEFQSNFSKNKKWFFEENLKIERTHIQRIFKKVNMSCKPPMTQHQLSICVKQINSTLVQLQNHYKRTSNIHFQDFKQYLIREFEILFQNYTNIFKTANLMTKLQSVRDYLTSAPVNLSYEDSSSKEYKRQILKCNSPISFDHPTSNSHATPIMSIVVTTVILLILIILTFIGTIVIKFCGQPFHRSTPNYVMSVVFDANQTQGPMPQSDQNLSENSNKQNVKLTLYENPIFHAKSATKPIEKQSLIENMES 463

The following BLAST results are available for this feature:

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Celegans
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Sea Lamprey
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Yeast
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Nematostella
BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
BLAST of Amyloid beta (A4) precursor protein b vs. Planmine SMEST

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
APP	1.662e-12	34.96	amyloid beta precursor protein [Source:HGNC Symbol...	[more]
APP	1.724e-12	34.96	amyloid beta precursor protein [Source:HGNC Symbol...	[more]
APP	1.876e-12	34.11	amyloid beta precursor protein [Source:HGNC Symbol...	[more]
APP	1.883e-12	34.11	amyloid beta precursor protein [Source:HGNC Symbol...	[more]
APP	2.147e-12	34.11	amyloid beta precursor protein [Source:HGNC Symbol...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
apl-1	2.560e-15	29.48	Amyloid-beta-like protein [Source:UniProtKB/Swiss...	[more]
apl-1	2.704e-15	29.48	Amyloid-beta-like protein [Source:UniProtKB/Swiss...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Appl	1.497e-12	27.27	gene:FBgn0000108 transcript:FBtr0307293	[more]
Appl	1.632e-12	27.27	gene:FBgn0000108 transcript:FBtr0307295	[more]
Appl	4.087e-11	27.27	gene:FBgn0000108 transcript:FBtr0070109	[more]
Appl	4.115e-11	27.27	gene:FBgn0000108 transcript:FBtr0307294	[more]
Appl	4.273e-11	27.27	gene:FBgn0000108 transcript:FBtr0307291	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
appb	2.772e-12	31.06	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]
appb	3.374e-12	31.06	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]
appb	3.379e-12	31.06	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]
appb	3.430e-12	31.06	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]
appb	3.432e-12	31.06	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gtf2e2	4.163e-12	33.33	general transcription factor IIE subunit 2 [Source...	[more]
gtf2e2	4.560e-12	33.33	general transcription factor IIE subunit 2 [Source...	[more]
gtf2e2	4.799e-12	33.33	general transcription factor IIE subunit 2 [Source...	[more]
gtf2e2	4.925e-12	33.33	general transcription factor IIE subunit 2 [Source...	[more]
gtf2e2	5.406e-12	33.33	general transcription factor IIE subunit 2 [Source...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
App	6.499e-13	34.11	amyloid beta (A4) precursor protein [Source:MGI Sy...	[more]
App	6.558e-13	34.11	amyloid beta (A4) precursor protein [Source:MGI Sy...	[more]
App	7.266e-13	34.11	amyloid beta (A4) precursor protein [Source:MGI Sy...	[more]
App	7.516e-13	34.11	amyloid beta (A4) precursor protein [Source:MGI Sy...	[more]
App	8.319e-13	34.11	amyloid beta (A4) precursor protein [Source:MGI Sy...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q06BR2\|A4_DORPE	1.257e-14	28.83	Amyloid-beta precursor-like protein OS=Doryteuthis...	[more]
sp\|Q10651\|A4_CAEEL	3.439e-14	29.48	Amyloid-beta-like protein OS=Caenorhabditis elegan...	[more]
sp\|P08592\|A4_RAT	5.477e-12	34.11	Amyloid-beta A4 protein OS=Rattus norvegicus OX=10...	[more]
sp\|P12023\|A4_MOUSE	5.819e-12	34.11	Amyloid-beta A4 protein OS=Mus musculus OX=10090 G...	[more]
sp\|Q5IS80\|A4_PANTR	9.873e-12	34.11	Amyloid-beta A4 protein OS=Pan troglodytes OX=9598...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3JZF2	4.821e-16	30.63	amyloid-beta-like protein OS=Lingula unguis OX=757...	[more]
A0A067QLF7	2.119e-13	28.74	Beta-amyloid-like protein (Fragment) OS=Zootermops...	[more]
A0A2A6B2I0	2.999e-13	29.65	Apl-1 OS=Pristionchus pacificus OX=54126 GN=PRIPAC...	[more]
H3FMK4	2.999e-13	29.65	Apl-1 OS=Pristionchus pacificus OX=54126 GN=WBGene...	[more]
A0A0K2UWH1	3.177e-13	32.52	Betaamyloidlike proteinlike [Bombus terrestris] OS...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000015571.2	6.971e-13	31.91	pep primary_assembly:Astyanax_mexicanus-2.0:12:313...	[more]
appb	9.946e-13	31.06	amyloid beta A4 protein-like [Source:NCBI gene;Acc...	[more]
appb	2.242e-12	31.06	amyloid beta A4 protein-like [Source:NCBI gene;Acc...	[more]
appb	2.337e-12	31.06	amyloid beta A4 protein-like [Source:NCBI gene;Acc...	[more]
appb	2.523e-12	31.06	amyloid beta A4 protein-like [Source:NCBI gene;Acc...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO45291	1.287e-12	31.69	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
appb	6.903e-13	31.82	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]
appb	8.213e-13	31.82	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]
APP	8.098e-12	30.77	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]
APP	1.526e-11	30.77	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]
APP	1.570e-11	30.77	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]

BLAST of Amyloid beta (A4) precursor protein b vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000057580.1	0.000e+0	98.70	SMESG000057580.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30003584 ID=SMED30003584|Name=Amyloid beta (A4) precursor protein b|organism=Schmidtea mediterranea sexual|type=transcript|length=1718bp
ATTTTTTAGCATTTAATTTTAAATTAAATTTTAAATGAATAGTAAATCAA
TTATAATTTTATTAATTTCATTATTCTCTCCGAATTTCGTCCATCTTCAA
TTCATACCATCAATTTCATATCACGCAGGTTCTAGTATTATGTACAAAAC
CGACAAAGGTTGGATACTGAATGAAAATATTACCATTAAACATTCACATG
ATATTCTAAAAGTCTGCCAAACGGTCTATCCAAATTATAACATAACTAAT
GTCATGAAGATATATCAAATAGAAACTATTACCAATTGGTGTCACGGAGG
TCGTAATTGTACAAGAAATATGTCTTATGATGTTCATCCATTCCGATGTT
TAAATTCCACACATGAAAGAGAAACATTTAAAGTTCCCATAAATTGTCAG
CAGACATTGGAAAATCGTCCTGAATGTTTGTCATTTGATACTTGGAAAAA
CATTTCCGTAACACTTTGTTCTGAATCTTATTCTTATGTAGTGGATATGA
TACAATATTCGCCTTGCACTGACAAAGTCATGATATTTTCTAAAGTAGAT
ATCATTTGTTGCCCTGCAGACAAGAAATATTACAACAGCCTGCTGAATAC
ATATCTGAAAGGTAGTCATAATGAACGGTGGATATTCTCCCAGTTGAGAC
ATGCCCTATTGTTATTGTATAGAGTCAAATTACGAAACCTAGGACGAGAT
ATTTGCGCCAAACAAAATCTCATTTCTATGAGACATGATAAATCATCGCT
CAAAGAAGATTTGGAAAATCTAAAATTGGAATTCCAAAGCAACTTTTCTA
AAAACAAGAAATGGTTTTTTGAGGAAAATTTAAAAATCGAAAGAACTCAT
ATTCAACGAATCTTCAAAAAAGTAAATATGAGCTGTAAACCTCCAATGAC
TCAACATCAACTATCCATCTGTGTGAAACAAATCAATTCTACACTCGTCC
AACTGCAGAATCATTACAAGCGCACCTCAAATATTCATTTCCAAGACTTT
AAACAATACTTAATCCGGGAGTTTGAAATTTTATTTCAGAATTATACAAA
TATTTTCAAAACGGCAAATTTAATGACAAAGTTACAAAGTGTAAGAGATT
ATCTAACTTCAGCGCCTGTAAACCTTTCGTACGAAGATTCCTCAAGCAAA
GAATATAAGCGGCACATATTGAAATGCAATAGTCCTATTTCATTTGATCA
TCCTACGTCTAATTCACATGCTACTCCAATTATGTCAATTGTCGTGACAA
CCGTGATCCTGCTGATCCTTATAATATTGACTTTTATTGGAACTATCGTG
ATCAAATTTTGCGGTCAACCATTTCATCGTTCGACTCCGAATTACGTTAT
GTCGGTTGTGTTCGATGCCAATCAAACCCAGGGACCAATGCCACAATCGG
ACCAGAATCTTTCGGAAAATTCCAACAAACAGAACGTAAAACTTACTCTC
TACGAAAATCCTATTTTCAACGCAAAATCTGCAACCAAACCTATCGAAAA
ACAATCTCTCATAGAAAATATGGAAAGTTAATATCAAGAATTTTAGTTTA
TTTGTTTTAAAACATTTACCCATGTTCGCGTTGCAGATATTATCAGCTTG
GGTTTTATATTTAAGTCCTGTGCAATTCATTGGACTGGACTAATGGCATT
GTACATTTACATCTGTCGTGAACTTATTATCCTCTGGACCTTTTATTTTG
ATATTGCTTTTCTACTTG

protein sequence of SMED30003584-orf-1

>SMED30003584-orf-1 ID=SMED30003584-orf-1|Name=SMED30003584-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=499bp
MNSKSIIILLISLFSPNFVHLQFIPSISYHAGSSIMYKTDKGWILNENIT
IKHSHDILKVCQTVYPNYNITNVMKIYQIETITNWCHGGRNCTRNMSYDV
HPFRCLNSTHERETFKVPINCQQTLENRPECLSFDTWKNISVTLCSESYS
YVVDMIQYSPCTDKVMIFSKVDIICCPADKKYYNSLLNTYLKGSHNERWI
FSQLRHALLLLYRVKLRNLGRDICAKQNLISMRHDKSSLKEDLENLKLEF
QSNFSKNKKWFFEENLKIERTHIQRIFKKVNMSCKPPMTQHQLSICVKQI
NSTLVQLQNHYKRTSNIHFQDFKQYLIREFEILFQNYTNIFKTANLMTKL
QSVRDYLTSAPVNLSYEDSSSKEYKRHILKCNSPISFDHPTSNSHATPIM
SIVVTTVILLILIILTFIGTIVIKFCGQPFHRSTPNYVMSVVFDANQTQG
PMPQSDQNLSENSNKQNVKLTLYENPIFNAKSATKPIEKQSLIENMES*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0007399	nervous system development

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR008154	Amyloid_glyco_extra
IPR015849	Amyloid_glyco_heparin-bd

Vocabulary: **molecular function**
Term	Definition
GO:0008201	heparin binding
GO:0046914	transition metal ion binding

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

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Amyloid beta (A4) precursor protein b

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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