Telomerase protein component 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003493 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 15Note: Hover over icons to view figure legend
Homology
BLAST of Telomerase protein component 1 vs. Ensembl Human
Match: TEP1 (telomerase associated protein 1 [Source:HGNC Symbol;Acc:HGNC:11726]) HSP 1 Score: 408.297 bits (1048), Expect = 6.025e-114 Identity = 444/1970 (22.54%), Postives = 812/1970 (41.22%), Query Frame = 1
Query: 445 INNLSKMDLYV--DISKE----DPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKYRNKKMVA------------------------------------EINGKKI-------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFN-----------------ETILKTNEK-------LIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIP--PIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDE---------------MVAGRVQFDMILSFDVSISEQCVS-----QYIKYNPSVL---IIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKY------GLKNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINN--SILSECHGEQTRYKSIMKETLTFLKSYTENIESFQK-------DEVNQLLL----IVEKKLSFEIDIDSPVNCQSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNL--PFPMKSYLKK---ELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKYSMSIDKT-----VVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEET-NSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYK-KDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISILN-SNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLD--------SILTIDVCKELILVGCKDGSXX--XXXXXXXXXXNHEIKA-HNDWITTVRFNSFNYFLSGSND 5829
+NN S L +I +E +PEFILK SLY R++LN+R+++N ++A++ + RP+L++Y +I+ LP+DW++V Y ++ LP L+ A+ +KF F YQL KY +K A E G + + +LK +V+ LHI +P ++V +LLG YP F S+LPG WD S+AGKRMK+ PETWE ++S+ GNK +W++LI+N LP+MAM+RN+ NLL+ I +H + Q ++ +VIH + PF++ A+ ++ IL NEK L + + + + + R +++ K Q E ++ RY +AL TA+ +S +++P P R ++ L + N + P + + L+ M A + + D+L ++LK IL K + V + FDE + RV D ++ S+ + ++ + + N L I+ + + +N N V + G + +K I+E + +++ + MD+ + G ++ L PL +D+P+ + + I +FISSTF DM ER ++ ++P+++ + I ++ IDLRWGV + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E FL +N R + L FRD+ +V + +K + + E I+ S LS G R + + Y +E F + + + +L L ++E+ +S D Q P S D + +L G + ++ G+ G GKT+ ++ L+S + P+ K + V + + LL + +L L P + S + ELQ S E P + + IDG D L D + WIP LP ++++ S++ L + + + + + + P+ + +++ L GK L+ +PF+N M +KR+S +P++L++ +H+ L T Y++V E + LP+T+ L+ + L ++EKE ++ + L ++SG T+ L ++S++ + + A N + M P + LL E ++ G R+ + + G L T K H +I+ + D FR D+ Y+ +S LTN+ + +LG+ LL + + + E KL F+TF+ + + L + P QQA N+PL S + C++ ++ + + + + NK T K + SSL +S + VAF + ++ +G + L +L+ ++ ++ ++ F ++DT L + DGL +W G + K H +T C +S L+ TV L +W T + L +NC+ HP + G W G++ + ++ K L S +++ F+ + ++ + +W+ G +L + + + + G Q+ G + VWS +LG L ++ + + + G + I I S+ + Q DVA++++ LS V+ + + + E ++ + S +PV+ + + S S+D ++ L + K + F + S + + G +D S+ ++ K +L H A H DW+T + N +S S+D
Sbjct: 262 MNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTRNEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGE-MLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRL-CPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKT---------AVLKAEEGILKTAIKLQAQVQE-FDENDGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLN---PNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSL---RPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARA---APHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVM--------QFLNRNQRLQP-SAQALIYFRDSSF---------LSSVPDAWK------SDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSAL----QAPDGAKVASL--VFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQ---------------------VLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVW-------RTLPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPD---GPLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKL-----PEADVAVFRTFLRQQASILSQYPRLLPQQAANQPLDSPL---CHQASLLSRRW-HLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDT-LFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQV-IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHH-GFVAAALFLHAGCQLLTAGEDGK----VQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAW------LSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSD 2127
BLAST of Telomerase protein component 1 vs. Ensembl Human
Match: TEP1 (telomerase associated protein 1 [Source:HGNC Symbol;Acc:HGNC:11726]) HSP 1 Score: 343.199 bits (879), Expect = 6.220e-94 Identity = 396/1794 (22.07%), Postives = 734/1794 (40.91%), Query Frame = 1
Query: 811 KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFN-----------------ETILKTNEK-------LIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIP--PIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDE---------------MVAGRVQFDMILSFDVSISEQCVS-----QYIKYNPSVL---IIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKY------GLKNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINN--SILSECHGEQTRYKSIMKETLTFLKSYTENIESFQK-------DEVNQLLL----IVEKKLSFEIDIDSPVNCQSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNL--PFPMKSYLKK---ELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKYSMSIDKT-----VVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEET-NSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYK-KDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISILN-SNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLD--------SILTIDVCKELILVGCKDGSXX--XXXXXXXXXXNHEIKA-HNDWITTVRFNSFNYFLSGSND 5829
+ +LK +V+ LHI +P ++V +LLG YP F S+LPG WD S+AGKRMK+ PETWE ++S+ GNK +W++LI+N LP+MAM+RN+ NLL+ I +H + Q ++ +VIH + PF++ A+ ++ IL NEK L + + + + + R +++ K Q E ++ RY +AL TA+ +S +++P P R ++ L + N + P + + L+ M A + + D+L ++LK IL K + V + FDE + RV D ++ S+ + ++ + + N L I+ + + +N N V + G + +K I+E + +++ + MD+ + G ++ L PL +D+P+ + + I +FISSTF DM ER ++ ++P+++ + I ++ IDLRWGV + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E FL +N R + L FRD+ +V + +K + + E I+ S LS G R + + Y +E F + + + +L L ++E+ +S D Q P S D + +L G + ++ G+ G GKT+ ++ L+S + P+ K + V + + LL + +L L P + S + ELQ S E P + + IDG D L D + WIP LP ++++ S++ L + + + + + + P+ + +++ L GK L+ +PF+N M +KR+S +P++L++ +H+ L T Y++V E + LP+T+ L+ + L ++EKE ++ + L ++SG T+ L ++S++ + + A N + M P + LL E ++ G R+ + + G L T K H +I+ + D FR D+ Y+ +S LTN+ + +LG+ LL + + + E KL F+TF+ + + L + P QQA N+PL S + C++ ++ + + + + NK T K + SSL +S + VAF + ++ +G + L +L+ ++ ++ ++ F ++DT L + DGL +W G + K H +T C +S L+ TV L +W T + L +NC+ HP + G W G++ + ++ K L S +++ F+ + ++ + +W+ G +L + + + + G Q+ G + VWS +LG L ++ + + + G + I I S+ + Q DVA++++ LS V+ + + + E ++ + S +PV+ + + S S+D ++ L + K + F + S + + G +D S+ ++ K +L H A H DW+T + N +S S+D
Sbjct: 330 RFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTRNEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGE-MLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRL-CPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKT---------AVLKAEEGILKTAIKLQAQVQE-FDENDGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLN---PNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSL---RPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARA---APHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVM--------QFLNRNQRLQP-SAQALIYFRDSSF---------LSSVPDAWK------SDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSAL----QAPDGAKVASL--VFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQ---------------------VLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVW-------RTLPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPD---GPLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKL-----PEADVAVFRTFLRQQASILSQYPRLLPQQAANQPLDSPL---CHQASLLSRRW-HLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDT-LFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQV-IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHH-GFVAAALFLHAGCQLLTAGEDGK----VQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAW------LSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSD 2019
BLAST of Telomerase protein component 1 vs. Ensembl Human
Match: TEP1 (telomerase associated protein 1 [Source:HGNC Symbol;Acc:HGNC:11726]) HSP 1 Score: 337.421 bits (864), Expect = 2.483e-93 Identity = 299/1227 (24.37%), Postives = 535/1227 (43.60%), Query Frame = 1
Query: 493 DPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKYRNKKMVA------------------------------------EINGKKI-------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFN-----------------ETILKTNEK-------LIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIP--PIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDE---------------MVAGRVQFDMILSFDVSISEQCVS-----QYIKYNPSVL---IIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKY------GLKNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINN--SILSECHGEQTRYKSIMKETLTFLKSYTENIESFQK-------DEVNQLLL----IVEKKLSFEIDIDSPVNCQSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNL--PFPMKSYLKK---ELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIY 3777
+PEFILK SLY R++LN+R+++N ++A++ + RP+L++Y +I+ LP+DW++V Y ++ LP L+ A+ +KF F YQL KY +K A E G + + +LK +V+ LHI +P ++V +LLG YP F S+LPG WD S+AGKRMK+ PETWE ++S+ GNK +W++LI+N LP+MAM+RN+ NLL+ I +H + Q ++ +VIH + PF++ A+ ++ IL NEK L + + + + + R +++ K Q E ++ RY +AL TA+ +S +++P P R ++ L + N + P + + L+ M A + + D+L ++LK IL K + V + FDE + RV D ++ S+ + ++ + + N L I+ + + +N N V + G + +K I+E + +++ + MD+ + G ++ L PL +D+P+ + + I +FISSTF DM ER ++ ++P+++ + I ++ IDLRWGV + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E FL +N R + L FRD+ +V + +K + + E I+ S LS G R + + Y +E F + + + +L L ++E+ +S D Q P S D + +L G + ++ G+ G GKT+ ++ L+S + P+ K + V + + LL + +L L P + S + ELQ S E P + + IDG D L D + WIP LP ++++ S++ L + + + + + + P+ + +++ L GK L+ +PF+N M +KR+S +P++L++ +H+ L T Y++V E + LP+T+ L+ + L ++EKE ++ + L ++SG T+ L ++S++
Sbjct: 284 EPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTRNEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGE-MLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRL-CPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKT---------AVLKAEEGILKTAIKLQAQVQE-FDENDGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLN---PNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSL---RPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARA---APHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVM--------QFLNRNQRLQP-SAQALIYFRDSSF---------LSSVPDAWK------SDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSAL----QAPDGAKVASL--VFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQ---------------------VLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVW 1438
BLAST of Telomerase protein component 1 vs. Ensembl Human
Match: TEP1 (telomerase associated protein 1 [Source:HGNC Symbol;Acc:HGNC:11726]) HSP 1 Score: 212.231 bits (539), Expect = 4.481e-54 Identity = 325/1580 (20.57%), Postives = 622/1580 (39.37%), Query Frame = 1
Query: 1381 IIKRYTEALNTAIEISTLYNIP--PIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDE---------------MVAGRVQFDMILSFDVSISEQCVS-----QYIKYNPSVL---IIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKY------GLKNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINN--SILSECHGEQTRYKSIMKETLTFLKSYTENIESFQK-------DEVNQLLL----IVEKKLSFEIDIDSPVNCQSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNL--PFPMKSYLKK---ELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKYSMSIDKT-----VVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEET-NSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYK-KDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISILN-SNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLD--------SILTIDVCKELILVGCKDGSXX--XXXXXXXXXXNHEIKA-HNDWITTVRFNSFNYFLSGSND 5829
++ RY +AL TA+ +S +++P P R ++ L + N + P + + L+ M A + + D+L ++LK IL K + V + FDE + RV D ++ S+ + ++ + + N L I+ + + +N N V + G + +K I+E + +++ + MD+ + G ++ L PL +D+P+ + + I +FISSTF DM ER ++ ++P+++ + I ++ IDLRWGV + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E FL +N R + L FRD+ +V + +K + + E I+ S LS G R + + Y +E F + + + +L L ++E+ +S D Q P S D + +L G + ++ G+ G GKT+ ++ L+S + P+ K + V + + LL + +L L P + S + ELQ S E P + + IDG D L D + WIP LP ++++ S++ L + + + + + + P+ + +++ L GK L+ +PF+N +R+S +P++L++ +H+ L T Y++V E + LP+T+ L+ + L ++EKE ++ + L ++SG T+ L ++S++ + + A N + M P + LL E ++ G R+ + + G L T K H +I+ + D FR D+ Y+ +S LTN+ + +LG+ LL + + + E KL F+TF+ + + L + P QQA N+PL S + C++ ++ + + + + NK T K + SSL +S + VAF + ++ +G + L +L+ ++ ++ ++ F ++DT L + DGL +W G + K H +T C +S L+ TV L +W T + L +NC+ HP + G W G++ + ++ K L S +++ F+ + ++ + +W+ G +L + + + + G Q+ G + VWS +LG L ++ + + + G + I I S+ + Q DVA++++ LS V+ + + + E ++ + S +PV+ + + S S+D ++ L + K + F + S + + G +D S+ ++ K +L H A H DW+T + N +S S+D
Sbjct: 1 MLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRL-CPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKT---------AVLKAEEGILKTAIKLQAQVQE-FDENDGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLN---PNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSL---RPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARA---APHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVM--------QFLNRNQRLQP-SAQALIYFRDSSF---------LSSVPDAWK------SDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSAL----QAPDGAKVASL--VFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQ---------------------VLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNN-------QRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVW-------RTLPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPD---GPLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKL-----PEADVAVFRTFLRQQASILSQYPRLLPQQAANQPLDSPL---CHQASLLSRRW-HLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDT-LFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQV-IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHH-GFVAAALFLHAGCQLLTAGEDGK----VQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAW------LSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSD 1470
BLAST of Telomerase protein component 1 vs. Ensembl Human
Match: WDR38 (WD repeat domain 38 [Source:HGNC Symbol;Acc:HGNC:23745]) HSP 1 Score: 63.929 bits (154), Expect = 1.136e-9 Identity = 37/157 (23.57%), Postives = 75/157 (47.77%), Query Frame = 1
Query: 4609 HHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKT-KSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNK-STKSIVFHPYYDLFLTTTINGEINVW 5073
H VN + F + L++ SEDG W + G LL L GH GPV C S +L + S D +W + ++LK + + ++ P++ ++ G W+ + ++++ + + + +L ++ S +S F P + T + + +++W
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR-QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
BLAST of Telomerase protein component 1 vs. Ensembl Fly
Match: CG3071 (gene:FBgn0023527 transcript:FBtr0070398) HSP 1 Score: 59.3066 bits (142), Expect = 3.801e-8 Identity = 62/288 (21.53%), Postives = 122/288 (42.36%), Query Frame = 1
Query: 4561 IQLFNLKQFEALLNLRHHFSRVNKTFF---YNNDTRLISVS-EDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSP-----INCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVA-VLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRS-PFFGINVWST--TLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNK---LQKTICDVA 5376
+Q++NL + NL SR KT + + D RL++ E+G ++ + +L++ KGH PV + + + D +W EK+++T + HP + G ++G + +Y+ V L + +S++F P +F++ ++ VW +G +L + ++ + ++ SDG ++ G R + ++ + T TL Y + ++ + D DQ +V G G +SI +K L+K D A
Sbjct: 63 VQIYNLVTMLVVKNL----SRFQKTAYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVAN---EKVVQTYEDTHTDYVRAGAMHPQAGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAG-GSQVRVWDLISGCRLLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLTYPNA---VVSMAVADG-DQAVVAGMVDGLVSIRRMMVDSKPSHLKKIRADRA 338
BLAST of Telomerase protein component 1 vs. Ensembl Fly
Match: CG7568 (gene:FBgn0039673 transcript:FBtr0330294) HSP 1 Score: 55.8398 bits (133), Expect = 3.712e-7 Identity = 44/216 (20.37%), Postives = 96/216 (44.44%), Query Frame = 1
Query: 4534 ISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNG-NMFIYNLNNYKKVAVL-----HNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNV-QYSSDGL 5160
I+ + G ++++++ L L HH + V F + L++ S D A +W +L L+GH +++C+ + +LI T SLD+ +W T K E L + + + +++ C + ++ L ++ +L H+++ +K + F P + LT + + +W + +G +V++ +S Y+ D +
Sbjct: 240 IATASLDGSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRGHSAELSNCVWNFSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSSDCTARVWRLEGSSELEMLSLMAGHSDEVSK-VCFSPSGCMLLTASADNTARLWLTESGQCSQVLAGHEGEVFSCAYSYAGDAI 454
BLAST of Telomerase protein component 1 vs. Ensembl Fly
Match: CG7568 (gene:FBgn0039673 transcript:FBtr0330295) HSP 1 Score: 55.8398 bits (133), Expect = 3.819e-7 Identity = 44/216 (20.37%), Postives = 96/216 (44.44%), Query Frame = 1
Query: 4534 ISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNG-NMFIYNLNNYKKVAVL-----HNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYS-NVQYSSDGL 5160
I+ + G ++++++ L L HH + V F + L++ S D A +W +L L+GH +++C+ + +LI T SLD+ +W T K E L + + + +++ C + ++ L ++ +L H+++ +K + F P + LT + + +W + +G +V++ +S Y+ D +
Sbjct: 240 IATASLDGSARIYDVETSHELQQLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRGHSAELSNCVWNFSGSLIATGSLDNTARIWDTRKLDQELYLAARHSDEVLDVSFDAAGQLLATCSSDCTARVWRLEGSSELEMLSLMAGHSDEVSK-VCFSPSGCMLLTASADNTARLWLTESGQCSQVLAGHEGEVFSCAYSYAGDAI 454
BLAST of Telomerase protein component 1 vs. Ensembl Fly
Match: U4-U6-60K (gene:FBgn0036733 transcript:FBtr0075209) HSP 1 Score: 51.9878 bits (123), Expect = 7.059e-6 Identity = 48/223 (21.52%), Postives = 94/223 (42.15%), Query Frame = 1
Query: 4444 AFTYKKDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPN--NDFKVIVGC--------WNGNMFIYNLNNYKKVAVL--HNNKSTKSIVFHPYYDLFLTTTINGEINVWS 5076
F ++ I+ + ++ ++S VAF ++ + +L++L+Q +L+ H V+ ++++ + L++ D VW G + L+GHLG V S I T S D+ +W L+ + P+ I +H N +D K C ++ I++ ++ + L H+NK S+ P TT+ + +WS
Sbjct: 338 GFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWD---------LRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVI-SVDIAPNSQYIATTSFDRTFKLWS 550
BLAST of Telomerase protein component 1 vs. Ensembl Fly
Match: Taf5 (gene:FBgn0010356 transcript:FBtr0088240) HSP 1 Score: 51.9878 bits (123), Expect = 8.154e-6 Identity = 42/208 (20.19%), Postives = 92/208 (44.23%), Query Frame = 1
Query: 4561 IQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEK-FVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNK-STKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFG 5178
+++ + + E +L H V + F L+S SED +WS + + + +GH+ PV D + + S D +W T+ L + S ++C+ HPN+++ V G + + +++ + V ++ +K S S+ F + +++ I +W +NG + + + + + + + +S DG + G
Sbjct: 432 VRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNY-VATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTL-LRHTSTVTTITFSRDGTVLAAAG 637
BLAST of Telomerase protein component 1 vs. Ensembl Zebrafish
Match: tep1 (telomerase-associated protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6153]) HSP 1 Score: 220.705 bits (561), Expect = 1.310e-60 Identity = 119/289 (41.18%), Postives = 171/289 (59.17%), Query Frame = 1
Query: 469 LYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSSCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEIN-----GKKI--------------------------------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEE 1224
L +I+ EDPEF+LKV++Y R+ELNIR +NYL+A++ + S+ +L++Y + LP+DWLEV Y + + S LP+ LKKAL++KFK FS YQL KY +K + N GK I + SLK MV LHI E E+VM++LGK YP AF S L G WD +AGK+MK+ P+TWE ++S GNK W+KLID KSLP+MAM+RN+RN++ I + +H K+ + ++ VI + PF++ +AYK++ E
Sbjct: 273 LATEITTEDPEFVLKVAVYTRQELNIRITANYLLALAAHLPASKQHLRRYFCPAVQLPSDWLEVARLYSMCFSKS-LPSCLKKALVDKFKQFSEYQLAKYNTRKHRCKHNKNQKKGKNISPEEWKKWGELLRVDEPILRKYKHTKKDKKESEFSLKKMVMRLHIKESAEHVMAILGKKYPSDLKAFSRSGLSGVWDRERAGKQMKLKQPDTWERKVSQEGNKAATWEKLIDGKSLPFMAMLRNLRNMITVGISEKHHSKILNRLSSKNAVIQSRQFPFRFLSAYKVILE 560
BLAST of Telomerase protein component 1 vs. Ensembl Zebrafish
Match: taf5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Source:ZFIN;Acc:ZDB-GENE-051120-180]) HSP 1 Score: 57.3806 bits (137), Expect = 2.121e-7 Identity = 47/204 (23.04%), Postives = 91/204 (44.61%), Query Frame = 1
Query: 4468 SSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKT-KSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKST-KSIVFHPYYDLFLTTTINGEINVW 5073
S +++ S + V+F N + S E G I+L++L+ F L+ + H V T F +S D +A +W++ L++ GHL VT +N + T S D +W +I K PI+ + PN F + G +G + ++++ + +A L + T ++ F ++ + +I+ + +W
Sbjct: 492 SKILHGHSGPVYGVSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVGYKGHNYPVWDTQFSPFGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVTCTRFHPNSNYVATGSSDRTVRLWDVLNGNCVRIFTGHKGPIHSLAFSPNGKF-LASGSTDGRVLLWDIGHGLMIAELKGHTGTIYALKFSRDGEIIASGSIDNTVRLW 694
BLAST of Telomerase protein component 1 vs. Ensembl Zebrafish
Match: daw1 (dynein assembly factor with WDR repeat domains 1 [Source:NCBI gene;Acc:556760]) HSP 1 Score: 56.225 bits (134), Expect = 3.699e-7 Identity = 47/226 (20.80%), Postives = 93/226 (41.15%), Query Frame = 1
Query: 4495 QISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWN------------GNMFIYNLNNYKKVAVLHNNKSTKS-IVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYS 5133
+I +AF L++ +L++++ E + L HF+ + F RL++ S D A++W G + VL GH G ++ + +LI T SLD +W E C+ + ++ +V+ C+N G +++ + ++ + L +K S + F+ LT +++ VW G L+V+ + +S
Sbjct: 179 EIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGG------------QCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFS 392 HSP 2 Score: 55.8398 bits (133), Expect = 4.400e-7 Identity = 31/111 (27.93%), Postives = 54/111 (48.65%), Query Frame = 1
Query: 4492 DQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMW 4824
D++ V F LI+ + G ++F+ F+ L L H ++K F +R+++ S D + VW GA L+VL+GH + C + + + I T S D+ +W
Sbjct: 304 DEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITGSKDNTCRIW 414
BLAST of Telomerase protein component 1 vs. Ensembl Zebrafish
Match: daw1 (dynein assembly factor with WDR repeat domains 1 [Source:NCBI gene;Acc:556760]) HSP 1 Score: 55.8398 bits (133), Expect = 4.881e-7 Identity = 47/226 (20.80%), Postives = 93/226 (41.15%), Query Frame = 1
Query: 4495 QISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWN------------GNMFIYNLNNYKKVAVLHNNKSTKS-IVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYS 5133
+I +AF L++ +L++++ E + L HF+ + F RL++ S D A++W G + VL GH G ++ + +LI T SLD +W E C+ + ++ +V+ C+N G +++ + ++ + L +K S + F+ LT +++ VW G L+V+ + +S
Sbjct: 179 EIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGG------------QCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFS 392
BLAST of Telomerase protein component 1 vs. Ensembl Zebrafish
Match: wdr13 (WD repeat domain 13 [Source:ZFIN;Acc:ZDB-GENE-050522-274]) HSP 1 Score: 55.4546 bits (132), Expect = 6.396e-7 Identity = 52/196 (26.53%), Postives = 88/196 (44.90%), Query Frame = 1
Query: 4432 KKNKAFTYKKDISSLVYYLSDQISHVAF-----GSILNLISMSYESGLIQLFNLKQFEALLNLRHHF-----SRVNKTFFYNNDTRLISV-SEDG-LALVWSSIEGALLKV-LKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTE--KFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKV 4974
+ A +++ +S Y L Q++ + GS++ + L + A + H F S V + F N+D L++ S DG L+++ S +KV LKGH GPVTD S ++I + S D +W TE + + E + S + C T P N+ +VG ++ + N++ KKV
Sbjct: 98 RAQGARGHRRSVSRGSYQLQAQMNRAVYDERPPGSLVPTSVAEASRAMAGDTTLSENYAFAGMHHIFDQHVDSAVPRLQFANDDKHLLACCSLDGTLSIMTLSPPPPTVKVTLKGHAGPVTDFAWSLSNDIIVSTSKDGTLRIWNTEDGRCIREVVDPEGSELLCCTFQPMNNNLTVVGNSKQHLQVVNISTGKKV 293
BLAST of Telomerase protein component 1 vs. Ensembl Xenopus
Match: hs3st5 (heparan sulfate-glucosamine 3-sulfotransferase 5 [Source:Xenbase;Acc:XB-GENE-5795358]) HSP 1 Score: 283.878 bits (725), Expect = 6.917e-76 Identity = 215/818 (26.28%), Postives = 384/818 (46.94%), Query Frame = 1
Query: 463 MDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNS----SCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKKIKL-----------------------------------------SLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETI------LKTNEKLIE----IELNSINKTKQKTLDRKN--------KVRNAIKLKKVSQRSV----VSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNET-----------------------------AIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDS--LVNRFQKNT---KCKSILKMSLDILSDNK---KGKITVTDLFDEMVAGRVQFDMILSFDVSIS----EQCVSQYIK-YNPSVLII------FNSINPPTETM---------------NCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFP-DAIPN-------EINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDY-EGLSVTNIE-YQFAS-------KNCQKIFLLKNSRDEDL 2475
+ L ++S DPEFILKV+LY R+ELNIRS +N+++AVS + RP+L++Y + + LP DW+E+ Y ++ + LP+ L++ L KF+ F+ YQL KY ++ + + +K K+ S+K++++ LHI +P +VM +LG YP +F S L G W +G++MK+ P+TW+ ++S+ GN +W+KL+D+ +P+MA++RN+RN++++ I +H +V + E VI ++ PF++ +AYK++++ N +LI+ E SI + K+ T R+ +R +K KK + R + + + I+++Y +AL +A++IS YNI P+ G+ +IL V+E+ + S ++ EV L++ M SE+ ++ L D ++ F ++ + K + D+ S + + K E++A R + D +L F +S + + QY + N L + + P + + N V + GF E ++ +SE + ++ + ++E++ + + VK S +F + IP+ I IFISSTF DM ER++I +IP ++ + + + +DLRWG+ + ++ L C+ ++ R IF+GILG R G +P + + LSE Y ++ Y G S+T +E QF +C+ F L RD DL
Sbjct: 339 LALCEELSNLDPEFILKVALYTRQELNIRSTANFMLAVSAFLPACRPHLRRYFCASVQLPADWMEIPRLYQSLAGQGEKLAPLPSCLRRVLTVKFQKFTEYQLAKYNTRRQRGKHSIRKPKVLNCQSTMKIGRNLRSVDKGLKLLQKKFSTPPTPKMKTKDRFSMKSLIQRLHISKPTHHVMGILGCKYPKDLYSFSKSGLEGPWQSDLSGQKMKLKQPQTWDRELSLKGNTGLVWEKLLDSDQVPFMALLRNLRNMIRAGISRQHHNQVTSRLSSERAVIKSRMFPFRFLSAYKVIQDLENQCHVSGKPFPVNVRLIKNIVTSEAASIPELKRYTWSRRQLRGCLAVPAIRQLLKRKKEALRKLRACKMDQAILQKYKKALESAVKISARYNITPLPGRTVILFYVSESMDKPCHGAKDLSVMLEDVSEDVSSDDSSQQSREEIRRHRSPTLLEVGLLLSGMVRDTSESAQVVLFNDQTYILAEFNSSSLLHNVSHLKKQAEDLKSQGRYSSRNKNVAKKYLMELLANRTKVDTLLLFRLSPPSAEFKSVLKQYRREVNTDCLCVTVVPENLQRVEEPDQRSEESHSESSAQEIGEESFDQCNDVVLHGFTEQVLRYVSERGTVRLLDHVAKVNERFQVPEDPD------SVKRSHDFGHEVIPSPITQRWRSIRIFISSTFRDMHSERNLIIGQVIPELRSRAACHY---LSVEEVDLRWGITEEETRKDRQLHLCLSEVCRSQIFIGILGERYGHVPKTYSLPLLSE-YEWIQRYPPGRSITELEAMQFLQNSDTENPGHCKAFFYL---RDADL 1143 HSP 2 Score: 168.318 bits (425), Expect = 1.010e-40 Identity = 181/816 (22.18%), Postives = 344/816 (42.16%), Query Frame = 1
Query: 3244 VTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFR---VYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE-DKKGRIIIKNSFIGNLITK-YSMSIDKT-VVHCIISIYCDEMLKFDDKFA--------FRDIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDIC----NRQTYK----DFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSN-TKPVILKKNKAFTYKKDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGY----------NSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKL-QKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGL 5589
+T+ IDG D L + +T WIP LP + ++++ S+L S +K++V + + + +++ + L GK L+ + F+N M +K+ + P++L +A + ++++ ++I+ LP+TL LI L+S+E+E + + + S+ G +DL ++S V+ K N +L A F A NLP+ + +++ + L R+ + + + + + K Y M D T H +++ + + +D + ++ ++ S LLT++ +L+ LG+ L Y+ +E + D +RQ K F+ FI +L L +NPS QQA+NEP C V C + ++I N T + + N Y S + + V+ + ++ SG + L N E + L V+ F ++D + S DG+ +W +G + + H +T C VS + T SLD Q +W+T + L + P+ C T HP V VG W+G + + L N++K AVL + S +++ F ++ +++G +++W+ ++L + +S + LQ ++ + VWS LG NS+ L V + Q + G G +S+ + + + + Q +I DV + + LS VT + + ++ + + H R V + + + S S D S+ L
Sbjct: 1368 LTLLIDGADLLCGRAGETTSEWIPEHLPQRINLVLSVTEGSSLGYSLARQKDTVSISLTSLQPSDRAELVRHWLAVYGKKLEESAFNNQMRLLLIKKGTKHPLYLTMACEELRATAVFERLSDDIEKLPATLPALIQRRLESLEQEHGVTTVSIALAVICLSRKGLPERDLLRILSSLQALNCVFTAKWNAMLAA-----FAGAQNLPMATFALLLRGVRSVLGLWLPALTSDHRLHLPSCLLRDAVEKRYLMKRDVTKAAHLLMAAHFWTVCSPEDPDSVPVINAECLSELSHHLLCSEQLHTLGWLLTHLPFLRVHAALGLLPHLCQVYSMYEILEQKNGPTTKDCTIHELDRQVSKLPVDVFREFIHNSLPVLSKNPSLFYQQALNEP--DCSPV-CFQARVIIDNRKECTSHLTMLWNNKPAYMSICRSKSLEIPSLLGCVSLSPSGRMAAVGASSGALHLINTDSGEEVRILHSGCDGVSACNFISDDLLCVG-SYDGILEIWKISDGCRMHRAEAHRRQITGCCVSPDQRQLITCSLDYQLKLWETSRGSLLGSISFPYPLACTTFHPRGHV-VAVGSWDGKITVLRLENWEKTAVLCGSSSVRTVSFSQDGKWLISGSLDGWVSLWAWEAQVQLS-----HFKAHSGSTLTCSFLQQGKYLLTGGEDSKVQVWSGGLGRLLGRVDGEIKNSSAISL----AVSPSRQLLAVGYHTGTVSVYSVDLGDLVAQTSIEDVTILCVAW------LSEEVLVTGTSDSLVRVWKISSGQFTCQLMLKEHQRFVQALAVSSKLLASASGDVSVCL 2158
BLAST of Telomerase protein component 1 vs. Ensembl Xenopus
Match: ngfr (nerve growth factor receptor [Source:Xenbase;Acc:XB-GENE-977685]) HSP 1 Score: 61.2326 bits (147), Expect = 1.221e-8 Identity = 51/217 (23.50%), Postives = 98/217 (45.16%), Query Frame = 1
Query: 4504 HVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKT--EKFVLEKILKTKSPINCITSHPN-NDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGE-INVWSSTNGMKLKVISMENKNYYSNVQ 5142
+V F + ++ + +++++++ + L + + H + VN F+ + L++ S DG + +EG L+ L GH GPV S + + + D+Q ++WKT +K+ +++I+K + C + P+ ND Y K LH + S SI +P ++L T T + I+V G NK+Y N++
Sbjct: 149 YVDFNPMGTCVASAGVDSTVKVWDIRTNKLLQHYQVHNAGVNSLSFHPSGNYLLTASNDGTVKILDLLEGRLIYTLHGHQGPVLSVAFSKSGDQFASGATDAQVLVWKTNFDKYNIKEIVKLQQKRTCPEAPPHLNDI------------------YPKTPHLHTS-SGHSIEINPMFELADTQTFDPPIIDV-----GANFPYCRQVNKDYCGNLE 341
BLAST of Telomerase protein component 1 vs. Ensembl Xenopus
Match: ngfr (nerve growth factor receptor [Source:Xenbase;Acc:XB-GENE-977685]) HSP 1 Score: 60.4622 bits (145), Expect = 2.140e-8 Identity = 45/190 (23.68%), Postives = 88/190 (46.32%), Query Frame = 1
Query: 4504 HVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKT--EKFVLEKILKTKSPINCITSHPN-NDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEI 5064
+V F + ++ + +++++++ + L + + H + VN F+ + L++ S DG + +EG L+ L GH GPV S + + + D+Q ++WKT +K+ +++I+K + C + P+ ND Y K LH + S SI +P ++L T T + I
Sbjct: 191 YVDFNPMGTCVASAGVDSTVKVWDIRTNKLLQHYQVHNAGVNSLSFHPSGNYLLTASNDGTVKILDLLEGRLIYTLHGHQGPVLSVAFSKSGDQFASGATDAQVLVWKTNFDKYNIKEIVKLQQKRTCPEAPPHLNDI------------------YPKTPHLHTS-SGHSIEINPMFELADTQTFDPPI 361
BLAST of Telomerase protein component 1 vs. Ensembl Xenopus
Match: ngfr (nerve growth factor receptor [Source:Xenbase;Acc:XB-GENE-977685]) HSP 1 Score: 60.4622 bits (145), Expect = 2.934e-8 Identity = 45/190 (23.68%), Postives = 88/190 (46.32%), Query Frame = 1
Query: 4504 HVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKT--EKFVLEKILKTKSPINCITSHPN-NDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEI 5064
+V F + ++ + +++++++ + L + + H + VN F+ + L++ S DG + +EG L+ L GH GPV S + + + D+Q ++WKT +K+ +++I+K + C + P+ ND Y K LH + S SI +P ++L T T + I
Sbjct: 191 YVDFNPMGTCVASAGVDSTVKVWDIRTNKLLQHYQVHNAGVNSLSFHPSGNYLLTASNDGTVKILDLLEGRLIYTLHGHQGPVLSVAFSKSGDQFASGATDAQVLVWKTNFDKYNIKEIVKLQQKRTCPEAPPHLNDI------------------YPKTPHLHTS-SGHSIEINPMFELADTQTFDPPI 361
BLAST of Telomerase protein component 1 vs. Ensembl Xenopus
Match: ENSXETT00000036352.1 (WD repeat domain 38 [Source:NCBI gene;Acc:100493075]) HSP 1 Score: 56.225 bits (134), Expect = 1.419e-7 Identity = 48/214 (22.43%), Postives = 89/214 (41.59%), Query Frame = 1
Query: 4612 HFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKS-PINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNK-STKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSP-----FFGINVWSTTLGY 5232
H VN + L++ S+D +W + G L + + GH GPV C S L + S D +WK + +L+ S + + P++ + ++ G W+ ++ + N +K V H ++ + + F T + + + VW + N K++ N S V +S G+ V E+ P FG +V + + Y
Sbjct: 20 HKGEVNSCALSPDCHLLLTCSDDSRIHLWEAKSGTLKQKVTGHTGPVKSCCFSPDGLLFASSSHDCTVRIWKVDTVECLHVLRDHSKSVETVCFSPDSRY-LLSGGWDCTAILWEVQNGQKRKVYHGHRDAIQCGAFSLNGSYIATGSWDYTVRVWIAQNKGTDKILEGHKSN-VSCVCFSISGMLVREYEGPLVPGTKQFVFGTHVMAPSSSY 231
BLAST of Telomerase protein component 1 vs. Ensembl Mouse
Match: Tep1 (telomerase associated protein 1 [Source:MGI Symbol;Acc:MGI:109573]) HSP 1 Score: 399.053 bits (1024), Expect = 2.715e-111 Identity = 427/1908 (22.38%), Postives = 804/1908 (42.14%), Query Frame = 1
Query: 445 INNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKY--------------------------RNK---KMVAEINGKKI----------------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETI------LKTNEKLIEIELNSINKTKQKTLDRKN-------KVRNA--------------IKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILI--LANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIY----LVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKI-TVTDLFDEMVAGRVQFDMILSFD-------VSISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGL---KNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEY-------QFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINNSILSECHGEQTRYKSIMKETLTFLKSYTENIESFQKDEVNQLLLIVEKK-LSFEIDIDSPVNC----------QSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMKSYLKKELQAHNEINSE------EFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNF---LLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKY---SMSIDKTVVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDICNRQTYKD---FKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKK-NKAFTYKKDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRP---------VIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCKELI 5685
+ S +++ ++ +PEFILK SLY R++LN+R I+N ++AV+ RP++++Y +I++LP+DW++V Y ++ LP L+ A+ +KF +F YQL KY R K K + + ++I + +LK +V LHI +P ++V +LLG YP T + F S LPG W+ S+AG+RMK+ PETWE ++S+ GNK +W++LIDN LP+MAM+RN+ NLL++ I +H V Q ++ E +V+H + PF++ A+ +++ + +N L++ + +K ++ RK+ ++R A ++L K Q + E +++RY +AL TA+ +S +N+ P+ G+ L+ L + N + P + + V+ L+ M A + T VK ++ + K L+ + L N + + T + R D ++ F + +++Q + Q++ N L + + + N V + G + +K I+E + +++ + +D+ + + + + PL ++ P I I +FISSTF DM ER ++ ++P+++ + + I ++ IDLRWG+ + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E Q + + Q + RD D L S D + + +++ K ++ Q E+ C + + + YT +E F + + + +++K+ L ++ P + Q TP S D + LL G + ++ G+ G GKT+ ++ L+S ++ PN F++ + + L NL + ++L+++L + + S E + + +K A + + + IDG D L D + WIP LP + ++++ S+S L + + + + + + + + +++ L GK L+ +PF+N M K+ S+ P++L + +++ L T Y++V E + LP+TL L+ + L ++E+E ++ + L ++SG T+ L ++S + + E ++ L ++ N F PLC P Y+ LL E ++ G R+ + + + I + + ++KT H +I+ + + D FR D+ Y+ +S + LTN+ + ++G+ LL + + + E N+ + D F TF+ + + L + P +QQA ++P S V C + ++ + + LK NK T K SL +S + VAF ++ SG I L NLK ++ + ++ +F + +DT L + DG +W G + K H +T C +S L+ TV L +W T + L +NC+ HP V G W G++ + + K L S S+ F+ + I+G + +W+ G +L + G + F + A D+F+ G G+ L S F + + CL + PLS V ++ + + + ED I I K+ S P +++L P+ ++SG++D S+ FK + L L + + +L + +EL+
Sbjct: 272 LTRASILEVCSALASLEPEFILKASLYARQQLNLRDIANTVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDEKKLVSLPACLRAAMTDKFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKTERPFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLVEYLHIHKPAQHVQALLGYRYPATLELFSRSHLPGPWESSRAGQRMKLRRPETWERELSLRGNKASVWEELIDNGKLPFMAMLRNLCNLLRTGISARHHELVLQRLQHEKSVVHSRQFPFRFLNAHDSIDKLEAQLRSKASPFPSNTTLMKRIMIRNSKKNRRPASRKHLCTLTRRQLRAAMTIPVMYEQLKREKLRLHKARQWNCDVE-LLERYRQALETAVNLSVKHNLSPMPGRTLLVYLTDANADRL-CPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGNDEWPLDTFGKYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHV--NSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARVF---PHRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYIPPSYDLPDHPHFHWTHEYPSGRSVTEMEVMQFLNRGQRSQPSAQALIYF---RDPDF----LSSVPDAWKPDFISESEEAAHRVSELK-----------RYLHEQKEVT------CRSYSCEWGGVAAG-----RPYTGGLEEFGQLVLQDVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLLQDTVQQLLLPHGRLSLVTGQAGQGKTAFLASLVSAL-KVPDQPNEPPFVFFHFAAARPD-----------------QCLALNLLRRLCTHLRQKLGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQT----------LVLIIDGADKLVDRNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETLQQSQGAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHSGNPF------PLC----PFAYLVQSLRSLLGEGPVERPGARLCLSDGPLRTTIKRRYGKRLGLEKT-AHVLIAAHLWKTCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAEFLTNLHVVAAYLEVGLVPDLLEAHVLYASSKPEANQ-------KLPAADVAVFHTFLRQQASLLTQYPLLLLQQAASQPEESPV---CCQAPLLTQRWHDQ--FTLKWINKPQTLKGQ-QSLSLTMSSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGIS-SFAFLSDTALFLTTFDGHLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYTHPKSLNCVAFHPEGQV-VATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPA-------------------QCGCVSAVLF-----------------------LHAGDRFLTAGED-GKAQ-LWSGFLGRPRG----------CL--GSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWLSPSVLVSGAEDGSLHGWMFKG-DSLHSLWLLSRYQKPVLGLAASRELM 2032
BLAST of Telomerase protein component 1 vs. Ensembl Mouse
Match: Tep1 (telomerase associated protein 1 [Source:MGI Symbol;Acc:MGI:109573]) HSP 1 Score: 80.1073 bits (196), Expect = 1.696e-14 Identity = 51/191 (26.70%), Postives = 97/191 (50.79%), Query Frame = 1
Query: 1882 NIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLK---NIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIE-YQFASKN 2430
N V + G + +K I+E + +++ + +D+ + + + + PL ++ P I I +FISSTF DM ER ++ ++P+++ + + I ++ IDLRWG+ + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E QF ++
Sbjct: 114 NDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARVF---PHRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYIPPSYDLPDHPHFHWTHEYPSGRSVTEMEVMQFLNRG 301
BLAST of Telomerase protein component 1 vs. Ensembl Mouse
Match: Wdr38 (WD repeat domain 38 [Source:MGI Symbol;Acc:MGI:1923896]) HSP 1 Score: 70.0922 bits (170), Expect = 6.376e-12 Identity = 48/189 (25.40%), Postives = 86/189 (45.50%), Query Frame = 1
Query: 4612 HFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKT-KSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNN-KSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMEN-KNYYSNVQ---YSSDGL 5160
H VN + F + L++ S+DG VW + G LL L GH GPV C S LI + S D +W + +LK + + ++ P++ ++ G W+ ++ + + ++V +L + S +S F P D T + + +++W V+S N + + N+ YS+ GL
Sbjct: 25 HHGEVNCSAFSPDGRTLLTASDDGCVYVWGTKSGRLLWRLAGHRGPVKSCCFSPDGRLIASSSSDHSIRLWDVARSKCLHVLKGHQRSVETVSFSPDSK-QLASGGWDKRAIVWEVQSGRRVHLLVGHCDSIQSSDFSPTSDSLATGSWDSTVHIWDLR--ASTPVVSYHNLEGHTGNISCLCYSASGL 210
BLAST of Telomerase protein component 1 vs. Ensembl Mouse
Match: Wdr38 (WD repeat domain 38 [Source:MGI Symbol;Acc:MGI:1923896]) HSP 1 Score: 70.0922 bits (170), Expect = 6.376e-12 Identity = 48/189 (25.40%), Postives = 86/189 (45.50%), Query Frame = 1
Query: 4612 HFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKT-KSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNN-KSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMEN-KNYYSNVQ---YSSDGL 5160
H VN + F + L++ S+DG VW + G LL L GH GPV C S LI + S D +W + +LK + + ++ P++ ++ G W+ ++ + + ++V +L + S +S F P D T + + +++W V+S N + + N+ YS+ GL
Sbjct: 25 HHGEVNCSAFSPDGRTLLTASDDGCVYVWGTKSGRLLWRLAGHRGPVKSCCFSPDGRLIASSSSDHSIRLWDVARSKCLHVLKGHQRSVETVSFSPDSK-QLASGGWDKRAIVWEVQSGRRVHLLVGHCDSIQSSDFSPTSDSLATGSWDSTVHIWDLR--ASTPVVSYHNLEGHTGNISCLCYSASGL 210
BLAST of Telomerase protein component 1 vs. Ensembl Mouse
Match: Wdr5b (WD repeat domain 5B [Source:MGI Symbol;Acc:MGI:1916794]) HSP 1 Score: 60.4622 bits (145), Expect = 1.033e-8 Identity = 53/217 (24.42%), Postives = 90/217 (41.47%), Query Frame = 1
Query: 4489 SDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKS-PINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVL--HNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYY 5130
S IS V F ++ S LI ++ L H ++ + ++ +RL+S S+D VW G LK LKGH V C + +NLI + S D +W+ + K L S PI+ + + N ++ G ++G I++ + + + L N + F P LT T++ + +W + G LK + Y
Sbjct: 39 SAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSL-IVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY 254 HSP 2 Score: 53.5286 bits (127), Expect = 2.050e-6 Identity = 43/189 (22.75%), Postives = 87/189 (46.03%), Query Frame = 1
Query: 4597 LNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSP-INCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIV-FHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDG 5157
L L H + ++ F N L S + D L ++W + +G K L GH ++D S+ ++ + + S D +W K LK S + C +P ++ ++ G ++ ++ I+ + K + L + S V F+ L ++ + +G +W + +G L+ ++ E S V++S +G
Sbjct: 33 LTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNL-IVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNG 220
BLAST of Telomerase protein component 1 vs. UniProt/SwissProt
Match: sp|Q99973|TEP1_HUMAN (Telomerase protein component 1 OS=Homo sapiens OX=9606 GN=TEP1 PE=1 SV=2) HSP 1 Score: 408.297 bits (1048), Expect = 2.893e-113 Identity = 444/1970 (22.54%), Postives = 812/1970 (41.22%), Query Frame = 1
Query: 445 INNLSKMDLYV--DISKE----DPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKYRNKKMVA------------------------------------EINGKKI-------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFN-----------------ETILKTNEK-------LIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIP--PIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDE---------------MVAGRVQFDMILSFDVSISEQCVS-----QYIKYNPSVL---IIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKY------GLKNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINN--SILSECHGEQTRYKSIMKETLTFLKSYTENIESFQK-------DEVNQLLL----IVEKKLSFEIDIDSPVNCQSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNL--PFPMKSYLKK---ELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKYSMSIDKT-----VVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEET-NSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYK-KDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISILN-SNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLD--------SILTIDVCKELILVGCKDGSXX--XXXXXXXXXXNHEIKA-HNDWITTVRFNSFNYFLSGSND 5829
+NN S L +I +E +PEFILK SLY R++LN+R+++N ++A++ + RP+L++Y +I+ LP+DW++V Y ++ LP L+ A+ +KF F YQL KY +K A E G + + +LK +V+ LHI +P ++V +LLG YP F S+LPG WD S+AGKRMK+ PETWE ++S+ GNK +W++LI+N LP+MAM+RN+ NLL+ I +H + Q ++ +VIH + PF++ A+ ++ IL NEK L + + + + + R +++ K Q E ++ RY +AL TA+ +S +++P P R ++ L + N + P + + L+ M A + + D+L ++LK IL K + V + FDE + RV D ++ S+ + ++ + + N L I+ + + +N N V + G + +K I+E + +++ + MD+ + G ++ L PL +D+P+ + + I +FISSTF DM ER ++ ++P+++ + I ++ IDLRWGV + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E FL +N R + L FRD+ +V + +K + + E I+ S LS G R + + Y +E F + + + +L L ++E+ +S D Q P S D + +L G + ++ G+ G GKT+ ++ L+S + P+ K + V + + LL + +L L P + S + ELQ S E P + + IDG D L D + WIP LP ++++ S++ L + + + + + + P+ + +++ L GK L+ +PF+N M +KR+S +P++L++ +H+ L T Y++V E + LP+T+ L+ + L ++EKE ++ + L ++SG T+ L ++S++ + + A N + M P + LL E ++ G R+ + + G L T K H +I+ + D FR D+ Y+ +S LTN+ + +LG+ LL + + + E KL F+TF+ + + L + P QQA N+PL S + C++ ++ + + + + NK T K + SSL +S + VAF + ++ +G + L +L+ ++ ++ ++ F ++DT L + DGL +W G + K H +T C +S L+ TV L +W T + L +NC+ HP + G W G++ + ++ K L S +++ F+ + ++ + +W+ G +L + + + + G Q+ G + VWS +LG L ++ + + + G + I I S+ + Q DVA++++ LS V+ + + + E ++ + S +PV+ + + S S+D ++ L + K + F + S + + G +D S+ ++ K +L H A H DW+T + N +S S+D
Sbjct: 262 MNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRCFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPSNITLMRRILTRNEKNRPRRRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGE-MLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRL-CPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKT---------AVLKAEEGILKTAIKLQAQVQE-FDENDGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLN---PNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSL---RPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARA---APHRISLHGIDLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVM--------QFLNRNQRLQP-SAQALIYFRDSSF---------LSSVPDAWK------SDFVSESEEAARRISELKSYLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSAL----QAPDGAKVASL--VFFHFSGARPDQGLALTLLRRLCTYLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQ---------------------VLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVW-------RTLPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLERPGARLCLPD---GPLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKL-----PEADVAVFRTFLRQQASILSQYPRLLPQQAANQPLDSPL---CHQASLLSRRW-HLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDT-LFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQV-IATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHH-GFVAAALFLHAGCQLLTAGEDGK----VQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAW------LSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSD 2127
BLAST of Telomerase protein component 1 vs. UniProt/SwissProt
Match: sp|O08653|TEP1_RAT (Telomerase protein component 1 OS=Rattus norvegicus OX=10116 GN=Tep1 PE=1 SV=1) HSP 1 Score: 403.675 bits (1036), Expect = 7.589e-112 Identity = 404/1697 (23.81%), Postives = 727/1697 (42.84%), Query Frame = 1
Query: 493 DPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKKI---------------------------------------------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEF-------------NETILK----TNEKLIEIELNS--INKTKQKTLDRKNKV--------RNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILIL----ANVNETAIYS-----PFKYGSSKSVKEVIALVTSMCYVASEATEIYL-----VKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKI-TVTDLFDEMVAGRVQFDMILSFD-------VSISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNI----VRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDA-IP------NEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNK--IILEKINFQNEINN--SILSECHGEQTRYKSIMKETLTFLKSYTENIESFQKDEVNQLLLIVEKK-LSFEIDIDSP----------VNCQSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWI-FDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMKSYLKKELQAHNEINSE------EFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKY---SMSIDKTVVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKK-NKAFTYKKDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISME 5115
+PEFILK SLY R++LN+R I+N ++AV+ RP++++Y +I++LP+DW++V Y ++ LP L+ A+ +KF F YQL KY +K ++ ++ + +LK +V LHI EP ++V +LLG YP T + F S LPG WD S+AG+RMK+ PETWE ++S+ GN+ +W++LIDN LP+MAM+RN+ NLL++ I H+H V Q ++ E +VIH + PF++ A+ L+ N T++K N K I+ N + Q+ L + R ++L K Q + E +++RY +AL TA+ IS +N+PP+ G+ L++ AN N S P Y + L+ M +E T ++L VK ++ + K L+ + L +N + + T + R D ++ F +++++Q + Q++ +F S+ M S N+ V + G + +K I+E + +++ + +D+ + + PL N P +P I +FISSTF DM ER ++ ++P+++ + I ++ IDLRWG+ + + L+ C+ +++ +FVGILGSR G+ P S + + + + G SVT +E FL + R E D L FRD F +P + K I E + ++ L E R S + + YT +E F + + + +++K+ L ++ P + Q +P S D + +L G + ++ G+ G GKT+ ++ L+S ++ PN F++ F + + L +NL + ++L ++L + + S E + + +K A + + + IDG D L D + WIP LP + ++++ S+S L + + +++ + + + + +++ L GK L+ +PF+N M K+ S+ P++L + +++ L T Y++V E + LP+TL L+ + L ++E+E + + L + SG T+ L ++S + + E + + + AS+ + + P Y+ LL E ++ G R+ + + + + + + ++KT H +I+ + +M D FR D+ Y+ +S + LTN+ + ++G+ LL Y + + E N+ F F+ + + L + P +QQA ++P S V C + ++ + N ILK NK T K SL +S + VAF ++ G I L NL+ ++ L ++ +F + +DT L + DGL +W G + K H +T C +S L+ TV L +W T + L +NCIT HP V G W+G + + + K L S +++ F + I+G + +W+ G +L +
Sbjct: 292 EPEFILKASLYARQQLNLRDIANIVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDEKKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRSKTRSRQPPRPQRTKPPFSESGKCFPKSVWPLKNEQISFEAAYNAVSEKKRLPRFTLKKLVEQLHIHEPAQHVQALLGYRYPSTLELFSRSHLPGPWDSSRAGQRMKLQRPETWERELSLRGNRASVWEELIDNGKLPFMAMLRNLCNLLRTGISAHHHELVLQRLQHEKSVIHSRQFPFRFLNAHDSLDRLEAQLRSKASPFPSNTTLMKRIMIRNSKKIKRPANPRYLCTLTQRQLRAAMAIPVMYEHLKREKLRLHKARQWTCDLE-LLERYRQALETAVNISVKHNLPPLPGRTLLVYLTDANANRLCPKSHLQGPPLNY---------VLLLIGMMMARAEQTTVWLCGTGTVKTPVLTADEGILKTAIKLQAQVQELEENDEWPLETFEKYLLSLAVRRTPIDRVILFGQRMDTELLNVAKQIIWQHVNSK----CLFVSVL--LRKMQYMSPNLNPNDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGPFVPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARAF---PHRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYTPPSYDLPDHPHFHWTQRYPSGRSVTEMEVM--------QFLNRGQRSEPSDQ-ALIYFRD-----------------PGFLSSVPDVWKPDFISESEEAAHRVSELKRFLQEQKEVTCRRYSCEWGGVAAGRPYTGGLEEFGQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDLIQASFQQLKSPPSPARPRLLQDTVQQLMLPHGRLSLVIGQAGQGKTAFLASLVSAL-KVPDQPNVAPFVFFHFSAAR------------------PDQCLAFNLLRRLCTHLHQKLGEPSALPSTYRGLVWELQQKLLLKSAQWLQPGQT----------LVLIIDGADKLVDHNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETLQQSQSAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHGHNVLPQALTALEVTHSGLTVDQLHAVLSTWLTLPKETKS-------WEEAVAASHSGNLYPLAPFAYLVQSLRSLLGEGPVERPGARLCLSDGPLRTAVKRRYGKRLGLEKT-AHVLIAAHLWKMCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAKFLTNLHVVAAYLEVGLVPDLLEAYELYASSKPEVNQ----KLPEADVAVFHNFLKQQASLLTQYPLLLLQQAASQPEESPV---CCQAPLLTQRWHNQ--CILKWINKPQTLKGQ-QSLSLPISSSPTAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGIS-SFAFLSDTALFLTTFDGLLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYTHPKSLNCITFHPEGQV-VATGNWSGIVTFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQ 1894
BLAST of Telomerase protein component 1 vs. UniProt/SwissProt
Match: sp|P97499|TEP1_MOUSE (Telomerase protein component 1 OS=Mus musculus OX=10090 GN=Tep1 PE=1 SV=1) HSP 1 Score: 399.053 bits (1024), Expect = 1.899e-110 Identity = 427/1908 (22.38%), Postives = 804/1908 (42.14%), Query Frame = 1
Query: 445 INNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKY--------------------------RNK---KMVAEINGKKI----------------KLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETI------LKTNEKLIEIELNSINKTKQKTLDRKN-------KVRNA--------------IKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILI--LANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIY----LVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKI-TVTDLFDEMVAGRVQFDMILSFD-------VSISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGL---KNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEY-------QFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINNSILSECHGEQTRYKSIMKETLTFLKSYTENIESFQKDEVNQLLLIVEKK-LSFEIDIDSPVNC----------QSFITPKST-------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMKSYLKKELQAHNEINSE------EFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNF---LLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDE---DKKG-RIIIKNSFIGNLITKY---SMSIDKTVVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDICNRQTYKD---FKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKK-NKAFTYKKDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHN-NKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRP---------VIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCKELI 5685
+ S +++ ++ +PEFILK SLY R++LN+R I+N ++AV+ RP++++Y +I++LP+DW++V Y ++ LP L+ A+ +KF +F YQL KY R K K + + ++I + +LK +V LHI +P ++V +LLG YP T + F S LPG W+ S+AG+RMK+ PETWE ++S+ GNK +W++LIDN LP+MAM+RN+ NLL++ I +H V Q ++ E +V+H + PF++ A+ +++ + +N L++ + +K ++ RK+ ++R A ++L K Q + E +++RY +AL TA+ +S +N+ P+ G+ L+ L + N + P + + V+ L+ M A + T VK ++ + K L+ + L N + + T + R D ++ F + +++Q + Q++ N L + + + N V + G + +K I+E + +++ + +D+ + + + + PL ++ P I I +FISSTF DM ER ++ ++P+++ + + I ++ IDLRWG+ + + L+ C+ +++ +FVGILGSR G+IP S + + + + G SVT +E Q + + Q + RD D L S D + + +++ K ++ Q E+ C + + + YT +E F + + + +++K+ L ++ P + Q TP S D + LL G + ++ G+ G GKT+ ++ L+S ++ PN F++ + + L NL + ++L+++L + + S E + + +K A + + + IDG D L D + WIP LP + ++++ S+S L + + + + + + + + +++ L GK L+ +PF+N M K+ S+ P++L + +++ L T Y++V E + LP+TL L+ + L ++E+E ++ + L ++SG T+ L ++S + + E ++ L ++ N F PLC P Y+ LL E ++ G R+ + + + I + + ++KT H +I+ + + D FR D+ Y+ +S + LTN+ + ++G+ LL + + + E N+ + D F TF+ + + L + P +QQA ++P S V C + ++ + + LK NK T K SL +S + VAF ++ SG I L NLK ++ + ++ +F + +DT L + DG +W G + K H +T C +S L+ TV L +W T + L +NC+ HP V G W G++ + + K L S S+ F+ + I+G + +W+ G +L + G + F + A D+F+ G G+ L S F + + CL + PLS V ++ + + + ED I I K+ S P +++L P+ ++SG++D S+ FK + L L + + +L + +EL+
Sbjct: 272 LTRASILEVCSALASLEPEFILKASLYARQQLNLRDIANTVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDEKKLVSLPACLRAAMTDKFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKTERPFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLVEYLHIHKPAQHVQALLGYRYPATLELFSRSHLPGPWESSRAGQRMKLRRPETWERELSLRGNKASVWEELIDNGKLPFMAMLRNLCNLLRTGISARHHELVLQRLQHEKSVVHSRQFPFRFLNAHDSIDKLEAQLRSKASPFPSNTTLMKRIMIRNSKKNRRPASRKHLCTLTRRQLRAAMTIPVMYEQLKREKLRLHKARQWNCDVE-LLERYRQALETAVNLSVKHNLSPMPGRTLLVYLTDANADRL-CPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGNDEWPLDTFGKYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHV--NSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARVF---PHRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYIPPSYDLPDHPHFHWTHEYPSGRSVTEMEVMQFLNRGQRSQPSAQALIYF---RDPDF----LSSVPDAWKPDFISESEEAAHRVSELK-----------RYLHEQKEVT------CRSYSCEWGGVAAG-----RPYTGGLEEFGQLVLQDVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLLQDTVQQLLLPHGRLSLVTGQAGQGKTAFLASLVSAL-KVPDQPNEPPFVFFHFAAARPD-----------------QCLALNLLRRLCTHLRQKLGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQT----------LVLIIDGADKLVDRNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETLQQSQGAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHSGNPF------PLC----PFAYLVQSLRSLLGEGPVERPGARLCLSDGPLRTTIKRRYGKRLGLEKT-AHVLIAAHLWKTCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAEFLTNLHVVAAYLEVGLVPDLLEAHVLYASSKPEANQ-------KLPAADVAVFHTFLRQQASLLTQYPLLLLQQAASQPEESPV---CCQAPLLTQRWHDQ--FTLKWINKPQTLKGQ-QSLSLTMSSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGIS-SFAFLSDTALFLTTFDGHLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYTHPKSLNCVAFHPEGQV-VATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPA-------------------QCGCVSAVLF-----------------------LHAGDRFLTAGED-GKAQ-LWSGFLGRPRG----------CL--GSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWLSPSVLVSGAEDGSLHGWMFKG-DSLHSLWLLSRYQKPVLGLAASRELM 2032
BLAST of Telomerase protein component 1 vs. UniProt/SwissProt
Match: sp|Q94818|TE80_TETTH (Telomerase component p80 OS=Tetrahymena thermophila OX=5911 PE=1 SV=1) HSP 1 Score: 126.716 bits (317), Expect = 5.486e-28 Identity = 82/273 (30.04%), Postives = 144/273 (52.75%), Query Frame = 1
Query: 814 LSLKNMVRILHICEPVENVMSLLGKNYPLTQD---AFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKT--NEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSV--VSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNETAIYSPF----KYGSSKSVKEVIALVTSMCYVASEATEIYL 1599
L+ K++++ HI EP E V +LGK YP T++ A F ++ AGKRMKI +TWE ++S GN E+W LI + LPYMAM+RN+ N+L++ + D H V I + V + K+ P Q+F+A +E NE + K +K + L + ++ +++ ++ + ++L++ + V+E I K+Y ++ AI+I+ N+ I+G I ++V+ + S KYGS ++ E ++ M E + Y+
Sbjct: 290 LTFKDLIKFCHISEPKERVYKILGKKYPKTEEEYKAAFGDSASAPFNPELAGKRMKIEISKTWENELSAKGNTAEVWDNLISSNQLPYMAMLRNLSNILKAGVSDTTHSIVINKICEPKAVENSKMFPLQFFSA---IEAVNEAVTKGFKAKKRENMNLKGQIEAVKEVVEKTDEEKKDMELEQTEEGEFVKVNEGIGKQYINSIELAIKIAVNKNLDEIKGHTAIFSDVSGSMSTSMSGGAKKYGSVRTCLECALVLGLMVKQRCEKSSFYI 559 HSP 2 Score: 66.6254 bits (161), Expect = 2.668e-9 Identity = 37/119 (31.09%), Postives = 65/119 (54.62%), Query Frame = 1
Query: 475 VDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVV--YHYMLISNSSCLPNQ-------------------LKKALINKFKDFSIYQLGKY 768
+++++ DPEFI ++++Y R EL IR+ +NY+VA V ++P+++KY + LP D LEV + I +++ N L++ + +KF +F+ YQLGKY
Sbjct: 74 LEVAESDPEFICQLAVYIRNELYIRTTTNYIVAFCVVHKNTQPFIEKYFNKAVLLPNDLLEVCEFAQVLYIFDATEFKNLYLDRILSQDIRKELTFRKCLQRCVRSKFSEFNEYQLGKY 192
BLAST of Telomerase protein component 1 vs. UniProt/SwissProt
Match: sp|Q54KD0|Y7407_DICDI (TPR repeat-containing protein DDB_G0287407 OS=Dictyostelium discoideum OX=44689 GN=DDB_G0287407 PE=4 SV=1) HSP 1 Score: 74.7146 bits (182), Expect = 1.307e-11 Identity = 39/128 (30.47%), Postives = 69/128 (53.91%), Query Frame = 1
Query: 2068 EINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSK-----------VIRNLSEIYPELKDYEGLSVTNIEYQF 2418
EI IFISS F DM+ +R I ++IP +++ L + I ++ +DLRWGV + + L C++++++C+I +G+ G R GW K + + +P +K+Y S+T IE++
Sbjct: 368 EIKIFISSPFKDMQLDRDQIVKVVIPRIRK---LCIERDIVLSYVDLRWGVTSNQSEQSTGLSMCLKELEKCNILIGLFGERYGWSSQEKQDPKSQQLLQSTLDRAIQDFPWVKNYRDSSITEIEFRM 492
BLAST of Telomerase protein component 1 vs. TrEMBL
Match: A0A369RW69 (Telomerase protein component 1 OS=Trichoplax sp. H2 OX=287889 GN=TrispH2_008664 PE=4 SV=1) HSP 1 Score: 496.508 bits (1277), Expect = 2.690e-138 Identity = 534/2102 (25.40%), Postives = 929/2102 (44.20%), Query Frame = 1
Query: 283 DDFQSSDNL--------VISD-SNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS----CLPNQLKKALINKFKDFSIYQLGKY-RNKKMVAEINGKKIKLS-----------------------------------LKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNET---AIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSL--VNRFQKNTKCKSILKMSLDILSDNKKGKITVT-DLFDEM-----VAGRVQFDMILSFDVSISE--------QCVSQYIK-YNPSVLIIFNSINPPTETMN----CKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPN-------FPDAIPN--EINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDY-EGLSVTNIEYQFA-----SKNCQKIF--LLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKI-NFQNEINNSILSECHGEQTRYKSIMKETLTFLKSYTENIESFQKDEVNQLLLIVEKKL-------SFEIDIDSPVNCQ---------SFITPKSTDKNENELLRSG--GILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMKSYLKKELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIH--EIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAI---LLDEDKKG-----RIIIKNSFIGNLI----TKYSMSIDKTVVHCIISIYCDEMLKFD----------DKFAFRDIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNG---FEETNSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHS-CVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYKKDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTE------KFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNN-KSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYN--SNEKDLLDITCV--DANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLL-KFKNYEVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSXXXXXXXXXXXXNHEIKAHNDWITTVRFNSF-NYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNFLSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKFLSTDYLLVVNA 6138
DDF + D++ SD SNL + C+I A+ L + FK + + L + N K+ +Y DPEFILKVSLY R+EL IR+ +N+L+A++ RPYLKKY +II LP+DW+EV Y + + + LP L+K +++KF F YQL KY R K+ + N K K S LK ++R LHI +P E+VM+L+GK YP+ ++F S L G W+ +A KRMK+P PETWETQ+S++GNK W+ LI+++ LP++A +RN+RNL+++ I D +H ++ + +E E++VI+ KL PF++FTA++ + + +T S +RK K N K K+V + VSE ++KRY EAL+ A++++T +N+ PI G LIL NV + + G +++ EV L+ M + E +E + D+ ++ F N SIL+ + I + +K IT + + F E + R+Q D ++ SE +++Y + NP++L + +++ + N V + GF++ +K +++ + ++ +D Y LK+I ++ N V S + F +P + +FISSTF+DM ER I+ + P ++ + N + +DLRWG+ Q +L+ C+ +++R F+ ILG R GW P + SE + +++Y SVT +E Q A S+ +K F + N+ + D+ L F D+ + I EKI N +N + + ++ I+ + K Y N+E F ++ L +E+ +FE D N Q FI K K N+LL GI++ GK G GKT++M+ L+ + W +I + S I NL LK+ EI + + + H LI + V IFIDG+D L + A L W+P ++P +++ N + + + R + +IH ++ I + K + +L+K K+L + F+ M KR+++ P+FL +A + + ++++ E I + T+ L+ +L+ IE + +EI F + SK G L +L+ + I+K+ ++ + + S LP+C P++Y + A+ L ++ ++ I++ I ++ TK S +H ++ + ++K D D +AF + Y+ + Y E LL +++++ + LG+ L+ DY+G FE + + K + +Q +DF F+S NL+ L N C QQA+NEPL++ + +IK + +N +I++ TY + + +A ++ + ++LF L + L + H V F + L S S DG VW G +L H + C V I + SLD I+WK KF +K+ P NC++ HP ++ G W+ N++ +++N ++ VL + S + + F + ++ I+G++ ++S +G V S+ + N S V A S + +W TLG S+ ++ +T V + +FI G+ G++SI++ N N+ I V C+ +T ++ +I + ++ IK+ S HS V I + +GS+DCSI L K Y + L + ++ I ++ +L D I L IK + ++H D ITT F S + ++ SND T+K W D S + + + +H + ++S+ + + S+S DGT+ + N G+ + + D + ++ FL DY L +
Sbjct: 229 DDFDAEDHMEKLYAPPKTSSDISNLKK-----CLINAASSSLIGSPDFK-SRKDFTRRQLKFLAN---KIQIY------DPEFILKVSLYTRQELGIRTAANFLLALAANIQACRPYLKKYFSTIIRLPSDWIEVAELYQSLHDKTIRIGSLPKALRKVMVDKFGGFDEYQLAKYNRQKRKKSSQNKKTDKTSQLDQAESNNYASEFNDIIFSDDSEDEEETVQMMFTLKQLIRKLHIIQPAEHVMALIGKKYPVDLESFHKSGLSGIWNSERANKRMKLPVPETWETQLSLHGNKASTWETLIEHQKLPFIATLRNLRNLIKAGISDKHHNRIIRRLENENSVINSKLFPFRFFTAFEAINGYEKT--------------SQAGESGNRFNRKFKKSNTKKKKQVEMQKTVSEALLKRYREALDNAVKVATNHNVAPICGSTLILCNVADVMKIPCTAARGLGKPRTLLEVGILLGLMFRYSCEQSEFIIYADNWKKIDVFNTN----SILENTESICTLVEKSMITTSPNGFPEQEMLKYLKDRIQLDNLILLSNGSSEVPNHSVMNSFLTKYRRVVNPNLLYVNVNLSGKVTGFDRNKKLSHENDVYVTGFSDQILKFVADRGGDGQLINVENIDNAYKLKSI-KIPNAISSVDKSEDKSYGIGTFDMFLPRWKTVRVFISSTFLDMHGERDILTRYVFPELRARCQRHFLNIFE---VDLRWGINEADIQHNSMLELCLTEVQRSDYFIAILGQRYGWCPQGYEVPPTSE-FDWVRNYPPNRSVTELEIQQAIFNNPSEAIRKCFCYIRDNTFESDIPKNWLLQFVDD--------------------------SDIAKEKIDNLKNRLRKCGVETYERYPCKWGGIVDK-----KPYLTNLEQFGLRVLHNLWNAIERDYIQNDNDNNFE---DEEYNTQISVVDLHSKDFIGRKRLCKESNDLLHESEQGIILYCGKKGCGKTALMARLVKDQMSTTN--------WCHRIIPYFIGSSSGSCK------------ITNLLHYFCRQLKRGADIVQEI-PDTYQELVTCFHEFLIQSASFHGSNP-----VIIFIDGLDQLNSYYNAKDLQWLPQLIPENVLFVVSVNENEDCFKNLEHRSD-IIHNFKLSGIDSWEKATFVRQILQKYRKSLDESNFNKQMNVLISKREASSPLFLTLACEELRMFGIFEQITERIKTISQTIHGLLEQTLERIEIDHGKEIVTALFQVVLSSKDGIDETYLPLLLGVLTLPEIKKDLMQISIKKLSQYT-TSALPIC----PLMYARLLRAVKEFLFPAQQQDLVSSCQLAIQHGKIKEVLESRYTKMERSNKLAFIHKTLAAF--YLVKADPTSNRSWEGFDPWAFIALPYHLIRGACYNELSELLCDLKFITAKCKLGLVNHLIDDYHGQVTFERVSED--KAYHKAMKQQKIQDFGNFVSRNLSILKTNAFLCQQQALNEPLNTYPAELAAAQIKTEARSSNN---LIMEWCNKPTYCNPCYMTLEGFQQPLLAIAISEDDQYVACGSKDCTVKLFELSTAKELKSFVGHARPVTDCCFIGSK-YLCSASLDGNISVWDLANGHRRHILSLHHRSICQCTVDRNEKFIASASLDGNVIIWKVNDGSSFGKFS----VKSNRPFNCVSFHPEAPL-IVAGNWDTNIYTWDVNTKEQKQVLRGHTASIRDVAFCNGGNFVISADISGQVMIFSLAHGT--NVGSLHGHFFPINKIAVSSNPHVL---ATASDDHKVKLWRNTLGRALFSSHFEMQRMTAVKISLSGKFIAVGSSNGDLSIIDRNVGNQ----ILSVQAHKQCIRSLTWSPCGLNIITASDDKTVKIINI--EHADIKETLSDHSAAVTCIASSKKYLATGSEDCSINLYHKHTVYRLDSNLSGHTACIAAV-DISSNEKYLLSSGHDKVIRLWNIKTKRCVIESHESHLDLITTCAFGSVHDTVVTASNDHTVKCW-----DASELSLVLHRKKVLIPVSEVHSHNSAVNTVSV-AKNLIASASSDGTVVISNRMGIEITSFKAHSDRINACHLV------FLDGDYYLTTSG 2189
BLAST of Telomerase protein component 1 vs. TrEMBL
Match: G3WIK5 (Telomerase associated protein 1 OS=Sarcophilus harrisii OX=9305 GN=TEP1 PE=4 SV=1) HSP 1 Score: 476.863 bits (1226), Expect = 4.399e-132 Identity = 444/1946 (22.82%), Postives = 842/1946 (43.27%), Query Frame = 1
Query: 463 MDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNS-----SCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAE--------------------------------------------INGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIEL-----------NSINKTKQKTLDRKNKV------------RNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEI-----YLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFD----EMVAGRVQFDMILSFDVSISE---QCVSQYI--KYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDE--KYGLKNIEELINCEPLVKDS-PNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPEL---KDY-EGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKIN-FQNEINNSILSECHGEQTRYKSIMKETLTFLKSYTENIESFQKDEVNQLLLIVEK-KLSFEIDIDSPVNCQSFITPKST-----------------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMK-SYLKKELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDEDKKGRIIIKNSFI----GNLITKYSMSID-----KTVVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYK-KDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTK-SIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDN----IIIKKVE-------SLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCKE--LILVGCKDGSXX---XXXXXXXXXXNHEIKAHNDWITTVRFNSFNYFLSGSND 5829
+ L D++ +PEFILK SLY R++LNIR I+ ++A++ Y RPY+++Y +I+ LP+DW++V + ++ + LP L+ A+ +KF F YQL KY +K A+ + K +LK +++ LHI +PV+NV +LLG YP +F S+LPG WD S+AG RMK+P PETW+ +S GNK +W+ LID+ LPYMAM+RN+ +LL+ I +H ++ Q +E++ +VI + LPF++ +A+ + + +LK+ + + L I K +Q +R + R +L K++Q E ++KRY +AL TA+ +S +N+PP+ G+ LI+ + + ++++ + L+ +M +E E+ Y++K +++N + K + L+ ++ +++ K + F +MVA RV D ++ ++ + Q+ + NP L + + ++ N V + G + +K ISE +++ + MD+ K + E I + L+++ P +P + + +FISSTF DM ER ++ ++P+++ + I++ IDLRWGV Q ++ L+ C+ +++ +FVGILGSR G++P + + + +P KDY G SVT +E FL + SR + + L RD+ +V + +K+ ++ E+I+ ++ ++ CH RY + + + Y + +E F + + + ++++ L E ++ + Q+ T +S D + RSG + ++ GKPG GKT+ +S L+S S + + F + ++ + L L T + L + PFP L ELQ +++ + + IDG D L D S WIP +LP K ++M+ + + L + R+++ + ++P+ + +++ L GK L+ PF+N M +KR + P++L++A +H+ L T Y++V E++ LP+T+ L+ + L +E+E +I + + L+ ++SG T+ L ++S + + L D+ + A N + M P Y+ + LL G + + + + G L + + KT H +I++ M D F D+ Y+ +S + SLLTN+ + ++G+ L + + + D + F TF+ + L + P+ QQA N+P +S + C+++ + +S ++P++ NK T + + SSL + V ++ SG++ L + ++ ++ ++ +N T ++ S DG +W G + +K H +TDC ++ L+ TVSLD +W T L + P+NC+ HP +I G W G + + ++ + + L + S+ S+ F P+ + + ++G + +W+ G +L ++ Y S+ + G Q+ G + VWS +LG ++ + + ++ G I I + TS E+S+ P+S + + + L+ ED ++ V H + V+ + S S+D ++ L E ++ + + + ++ G +D S+ + + +L+N H DW+T + LS SND
Sbjct: 281 LQLCTDLALLEPEFILKASLYARQQLNIRDIAIMVLAIAAYLPACRPYVRRYFCAIVQLPSDWMQVARFFQSLAEEPNRKLAPLPACLRAAMTDKFAQFDEYQLAKYNLRKHRAKKSHQRPRRPKSEKVCQRKWYNSTIIYKTFYNHQKSFMRAYHAEPVKKKPSDFTLKKLIQRLHIRDPVQNVKALLGCRYPSDMQSFARSRLPGPWDFSRAGTRMKLPQPETWDRVLSQKGNKASVWEGLIDSGKLPYMAMLRNLCSLLRVGISSRHHERILQLLERKESVIRSRQLPFRFLSAHTSISDLERQLLKSGPIPLNVVLMRQLLERLEKKGQIPKPQQHLTNRDLRFAMLVPVLYEHFKREKQRLNKINQWKQDWE-MMKRYQQALETAMNLSVQHNLPPLPGRTLIVCCPGRS-------QENKRNLQNHVLLLVAMVMARAEQAELLLCKRYILKKAVINPEEGILKTATELQTQIEEMAEEKSESKSNHHPFALYILDMVARRVPTDTVIFVGNTMEDPEFMSAKQFFWQRVNPKCLFVGVDLTGMHSGSLSRNPNDVILTGCTDGILKFISERGMSRLLEHVGQMDKIFKIPPQRGEAQIFPDKLLEERVPGPLTPVPQQSWRSVRVFISSTFRDMHGERDLLLRSVLPALQARA---APHHINVRGIDLRWGVTEEETQKDRQLELCLGEVENSQLFVGILGSRYGYVPPNYSLPD----HPHFCWAKDYPSGRSVTEMEVM--------QFLSRGSRHQ--SSPALIYLRDSSF---------LSSVPDAWKMDFASESEEAAERISELKSYLDKQEGVTCH----RYSCVWG-GVAAGRPYVKGLEEFGQMVLQHVWELLQRLYLQPESGLEETTSIQNDDTIQSAFQQLQRPPCPARPSLLKDTIQQLQQRSGSLCLVIGKPGQGKTAFLSSLVSALQAPSGVTMSSQV--FFHFVGARPDQSYVLILLRRLCTYLHHQLQCSRPFPTTYRGLVWELQTLLPKSAQSL----------------------RSGQTLVLVIDGADQLGDQSGQLISDWIPKILPQKVHLVMSMSAKTGLGDILQSRRDAHVVALKPLEPTARAQLVRQELALYGKRLEETPFNNQMRLLLVKRGAALPLYLRLATDHLRLFTLYEQVSEQLRALPATVPLLLQHMLGVLEQEHGSDILPLALAALHVTRSGLTLDQLHGVISTW-------QSLPLETVDWAEAMAARNQGDPYPMGPFTYLVHSLRSLLG---AGSLELPGARLRLPPGPLCSAAELRYRKRPGLKTTAHVLIAVQLWRMCDLDALGTFHNCHPEALSDLPYHLAQSGNHSLLASLLTNLNVMTTYLEMGLLSQLGEAHALYASSVP------VDEPSEPNVTVFHTFLKQQSKLLTQYPALLAQQAANQPSNSPI---CHQVSKLSQRWS-SQPILHWLNKPQTMEAQQRSSLSLVPPSTPTAVNLSPNGQRAIVATASGIVHLLDTCTWQEEKSIVSGCDGISSCLCPSNTTLFLAAS-DGRLELWDLQGGWRIFQIKAHQLQITDCCLNPDHRLLATVSLDRYLKLWDTIHGKLAAQHLFQKPLNCVAFHPEGQV-IITGNWAGYLSVLQPDSLRVIMELGGSGSSVCSVTFAPHGSVLAASHLDGIVELWAWQKGARLAAFPA-HQGYVSSALFLQSGHQLLTSGEDGK----VQVWSGSLGRPKGVLGSFSLSPALSVAISPDQTYVAVGHHTDGIRIYS----------------TSSGTEESHCPMSAVAVSALAWLSDRVLVSGGEDGDLQCWVLGDVAPTCLWLLPAHQKAVLGLATSQTLFASASEDFTVRLWSLSFLTQPEMIEELHGHKGPVTCCSFSPDGSILATGSRDQSLQCWNVRTPEAPVLINFLPACHRDWVTGCSWTKDAMLLSSSND 2120
BLAST of Telomerase protein component 1 vs. TrEMBL
Match: G3WIK6 (Telomerase associated protein 1 OS=Sarcophilus harrisii OX=9305 GN=TEP1 PE=4 SV=1) HSP 1 Score: 472.626 bits (1215), Expect = 8.061e-131 Identity = 444/1945 (22.83%), Postives = 842/1945 (43.29%), Query Frame = 1
Query: 463 MDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNS-----SCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAE------------------------------------------INGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIEL-----------NSINKTKQKTLDRKNKV------------RNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEI-----YLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFD----EMVAGRVQFDMILSFDVSISE---QCVSQYI--KYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDE--KYGLKNIEELINCEPLVKDS-PNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSE-KLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPEL---KDY-EGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKIN-FQNEINNSILSECHGEQTRYKSIMKETLTFLKSYTENIESFQKDEVNQLLLIVEK-KLSFEIDIDSPVNCQSFITPKST-----------------DKNENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMK-SYLKKELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDEDKKGRIIIKNSFI----GNLITKYSMSID-----KTVVHCIISIYCDEMLKFDDKFAFR--------DIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYK-KDISSLVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTK-SIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDN----IIIKKVE-------SLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCKE--LILVGCKDGSXX---XXXXXXXXXXNHEIKAHNDWITTVRFNSFNYFLSGSND 5829
+ L D++ +PEFILK SLY R++LNIR I+ ++A++ Y RPY+++Y +I+ LP+DW++V + ++ + LP L+ A+ +KF F YQL KY +K A+ + K +LK +++ LHI +PV+NV +LLG YP +F S+LPG WD S+AG RMK+P PETW+ +S GNK +W+ LID+ LPYMAM+RN+ +LL+ I +H ++ Q +E++ +VI + LPF++ +A+ + + +LK+ + + L I K +Q +R + R +L K++Q E ++KRY +AL TA+ +S +N+PP+ G+ LI+ + + ++++ + L+ +M +E E+ Y++K +++N + K + L+ ++ +++ K + F +MVA RV D ++ ++ + Q+ + NP L + + ++ N V + G + +K ISE +++ + MD+ K + E I + L+++ P +P + + +FISSTF DM ER ++ ++P+++ + I++ IDLRWGV Q + + L+ C+ +++ +FVGILGSR G++P + + + +P KDY G SVT +E FL + SR + + L RD+ +V + +K+ ++ E+I+ ++ ++ CH RY + + + Y + +E F + + + ++++ L E ++ + Q+ T +S D + RSG + ++ GKPG GKT+ +S L+S S + + F + ++ + L L T + L + PFP L ELQ +++ + + IDG D L D S WIP +LP K ++M+ + + L + R+++ + ++P+ + +++ L GK L+ PF+N M +KR + P++L++A +H+ L T Y++V E++ LP+T+ L+ + L +E+E +I + + L+ ++SG T+ L ++S + + L D+ + A N + M P Y+ + LL G + + + + G L + + KT H +I++ M D F D+ Y+ +S + SLLTN+ + ++G+ L + + + D + F TF+ + L + P+ QQA N+P +S + C+++ + +S ++P++ NK T + + SSL + V ++ SG++ L + ++ ++ ++ +N T ++ S DG +W G + +K H +TDC ++ L+ TVSLD +W T L + P+NC+ HP +I G W G + + ++ + + L + S+ S+ F P+ + + ++G + +W+ G +L ++ Y S+ + G Q+ G + VWS +LG ++ + + ++ G I I + TS E+S+ P+S + + + L+ ED ++ V H + V+ + S S+D ++ L E ++ + + + ++ G +D S+ + + +L+N H DW+T + LS SND
Sbjct: 163 LQLCTDLALLEPEFILKASLYARQQLNIRDIAIMVLAIAAYLPACRPYVRRYFCAIVQLPSDWMQVARFFQSLAEEPNRKLAPLPACLRAAMTDKFAQFDEYQLAKYNLRKHRAKKSHQRPRRPRNLESEWVERESTPRGHHREIQKSFMRAYHAEPVKKKPSDFTLKKLIQRLHIRDPVQNVKALLGCRYPSDMQSFARSRLPGPWDFSRAGTRMKLPQPETWDRVLSQKGNKASVWEGLIDSGKLPYMAMLRNLCSLLRVGISSRHHERILQLLERKESVIRSRQLPFRFLSAHTSISDLERQLLKSGPIPLNVVLMRQLLERLEKKGQIPKPQQHLTNRDLRFAMLVPVLYEHFKREKQRLNKINQWKQDWE-MMKRYQQALETAMNLSVQHNLPPLPGRTLIVCCPGRS-------QENKRNLQNHVLLLVAMVMARAEQAELLLCKRYILKKAVINPEEGILKTATELQTQIEEMAEEKSESKSNHHPFALYILDMVARRVPTDTVIFVGNTMEDPEFMSAKQFFWQRVNPKCLFVGVDLTGMHSGSLSRNPNDVILTGCTDGILKFISERGMSRLLEHVGQMDKIFKIPPQRGEAQIFPDKLLEERVPGPLTPVPQQSWRSVRVFISSTFRDMHGERDLLLRSVLPALQARA---APHHINVRGIDLRWGVTEEETQKDSRQLELCLGEVENSQLFVGILGSRYGYVPPNYSLPD----HPHFCWAKDYPSGRSVTEMEVM--------QFLSRGSRHQ--SSPALIYLRDSSF---------LSSVPDAWKMDFASESEEAAERISELKSYLDKQEGVTCH----RYSCVWG-GVAAGRPYVKGLEEFGQMVLQHVWELLQRLYLQPESGLEETTSIQNDDTIQSAFQQLQRPPCPARPSLLKDTIQQLQQRSGSLCLVIGKPGQGKTAFLSSLVSALQAPSGVTMSSQV--FFHFVGARPDQSYVLILLRRLCTYLHHQLQCSRPFPTTYRGLVWELQTLLPKSAQSL----------------------RSGQTLVLVIDGADQLGDQSGQLISDWIPKILPQKVHLVMSMSAKTGLGDILQSRRDAHVVALKPLEPTARAQLVRQELALYGKRLEETPFNNQMRLLLVKRGAALPLYLRLATDHLRLFTLYEQVSEQLRALPATVPLLLQHMLGVLEQEHGSDILPLALAALHVTRSGLTLDQLHGVISTW-------QSLPLETVDWAEAMAARNQGDPYPMGPFTYLVHSLRSLLG---AGSLELPGARLRLPPGPLCSAAELRYRKRPGLKTTAHVLIAVQLWRMCDLDALGTFHNCHPEALSDLPYHLAQSGNHSLLASLLTNLNVMTTYLEMGLLSQLGEAHALYASSVP------VDEPSEPNVTVFHTFLKQQSKLLTQYPALLAQQAANQPSNSPI---CHQVSKLSQRWS-SQPILHWLNKPQTMEAQQRSSLSLVPPSTPTAVNLSPNGQRAIVATASGIVHLLDTCTWQEEKSIVSGCDGISSCLCPSNTTLFLAAS-DGRLELWDLQGGWRIFQIKAHQLQITDCCLNPDHRLLATVSLDRYLKLWDTIHGKLAAQHLFQKPLNCVAFHPEGQV-IITGNWAGYLSVLQPDSLRVIMELGGSGSSVCSVTFAPHGSVLAASHLDGIVELWAWQKGARLAAFPA-HQGYVSSALFLQSGHQLLTSGEDGK----VQVWSGSLGRPKGVLGSFSLSPALSVAISPDQTYVAVGHHTDGIRIYS----------------TSSGTEESHCPMSAVAVSALAWLSDRVLVSGGEDGDLQCWVLGDVAPTCLWLLPAHQKAVLGLATSQTLFASASEDFTVRLWSLSFLTQPEMIEELHGHKGPVTCCSFSPDGSILATGSRDQSLQCWNVRTPEAPVLINFLPACHRDWVTGCSWTKDAMLLSSSND 2001
BLAST of Telomerase protein component 1 vs. TrEMBL
Match: A0A5F8GAK5 (Telomerase associated protein 1 OS=Monodelphis domestica OX=13616 GN=TEP1 PE=4 SV=1) HSP 1 Score: 457.988 bits (1177), Expect = 2.226e-126 Identity = 447/1914 (23.35%), Postives = 844/1914 (44.10%), Query Frame = 1
Query: 463 MDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKYRNKKMVA------------------------EINGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTN---------EKLIEIELNSINKTKQKTLDRKNKVRNAI-------KLKKVSQRSV-VSE-----NIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNETAIYSPFKYGSSK--SVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDEMVAGRVQFDMILSFDVSISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGL---KNIEELINCEPLVKDSPNFPDAIPNE----INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDY-EGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKI-NFQNEINNSILSECHGEQTRYKSIMKETLTFLKSYTENIESFQK---DEVNQLL--LIVEKKLSFE----IDIDSPVNC--QSFITPKSTDKN-------ENELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMKSYLKKELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFI--DGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRVYIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDED----KKGRIIIKNSFIGNLIT-KYSMSID-KTVVHCIISI----YCD--EMLKFDD--KFAFRDIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDYNGFEETNSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYKKDISSLVYYLSDQI-SHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDIT-----CVDANDQFIVCGTKFGEISIL-NSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNF--YLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFK---NYEVTEKLQLFNIFLDSILTIDVCK-----ELILVGCKDGSXX--XXXXXXXXXXNHEIKA-HNDWITTVRFNSFNYFLSGSNDFTIKLWEII 5856
+ L D++ +PEFILK SLY R++LNIR ++ ++A++ Y RPYL++Y +I+ LP+DW++V ++ ++ S +P L+ A+ KF F YQL KY ++ A + K +LK +++ LHI +PV+NV +LLG YP +F S+LPG WD S+AG RMK+P PETWE +S GN +W+ LID+ LPYMAM+RN+ +LL+ I +H ++ Q +E++S VI + LPF++ +A+ + + + + +L+E K + +R A+ K+ QR + +S ++KRY +AL TA+ +S +N+PP+ G+ LI I SP++ K + V+ LV +M +E E+ L K + + N + + ILK + ++ + ++ +T L M + + F+ ++Q Q + NP L + + +C + N V + G + +K ISE +++ + MD+ + + + + + PL + P+ P + IFISSTF DM ER ++ ++P+++ + I + IDLRWGV Q ++ L+ C+ +++ +FVGILGSR G++P + + + + +KDY G SVT +E FL + S + + L RD+ +V + +KI + E+I + ++ ++ CH RY S + + Y + +E F + V +LL L V+ + S E D V Q P S + + RSG + ++ G+PG GKT+ +S L+S +S+ ++ + + I L + +YL+ +LQ +S+ F P + + + +L K Q T+ + DG D L D + WIP LP K ++M+ +++ L+ + R+++ + ++ + + +++ L GK L+ PF+N M +KR + P++L++A +H+ L T ++++ E++ LP+T+ L+ + L +E+E +I + + L ++SG T+ L ++S + + E D+ + A N + M P Y+ LL E R+ + + + + +Y KT H +I++ CD + F + A D+ Y+ +S + SLLTN+ +LG+ L + + + + + F TF+ + L + P+ QQA N+P +S + + ++ +++P++ NK T SS + + + + V+ ++ SG++ L + + ++ ++ ++ +N T ++ S DGL +W G + K H +TDC +S L+ TVSLD +W T L ++ P+NC+ HP + G W G + + L++ S +++ F P + + ++G + +W+ G +L + Y ++ + G Q+ G + +WS +LG D L ++ + + F+ G I I S+ T + Q + D A++++ L+ V+ + N +++ + + + + H + V+ + + S S+D ++ L + + +KL + C ++ G +D S+ +++ + ++ H + A H DW+T + LS SND +++LW+ +
Sbjct: 222 LQLCTDLALLEPEFILKASLYARQQLNIRDMAIMVLAIAAYLPACRPYLRRYFCAIVQLPSDWMQVAQYFQNLAESPDKKLVPMPACLRAAMTEKFTQFDEYQLAKYNLREHRAKKRRRRYRRPVSDFFPFMRAYHEEPVKKKPSDFTLKKLIKRLHIRDPVQNVKALLGCRYPSDLQSFSRSRLPGPWDSSRAGTRMKLPQPETWERVLSQQGNTASVWEGLIDSGKLPYMAMLRNLCSLLRVGISAKHHERILQLLERKS-VIRSRQLPFRFLSAHTSISDLERQLKNSGPVPCNVVIMRQLLERLEKKKKLPKPERKLTNWDLRFAMMVPVLYEHFKREKQRLIQISHWKRDWEMMKRYQQALETAMNLSVQHNLPPLPGRTLI--------ICSPYESQDKKKNPLTHVLLLV-AMLMARAEQAELLLCKRGTLKKAVTNPE-EGILKTATEL---ETQIQVRLTGLLARMDTVIFVGNTMKDFEFMTAKQFFWQRV--NPKCLFVGVDL---MGMDSCTNPNDVILTGCTDGILKFISERGMSRLLEHVGQMDKIFKIPPPRGEAQTLPDRPLEEREPSPLTPAPQHSWRSVRIFISSTFRDMHGERDLLLRSVLPALQAQA---APHHISVRGIDLRWGVTEEEIQKDRQLELCLGEVENSQLFVGILGSRYGYVPPNSNLPDHPHFH-WVKDYPPGRSVTEMEVM--------QFLNRGSHQQGVSP-ALIYLRDSSF---------LSSVPDGWKIDFASESDEAAERISDLKSYLDKQEGVTCH----RY-SCAWGGVAAGRPYVKGLEEFGQMVLQHVWELLQRLYVQPESSLEKTESAQNDDTVQSAFQQLQHPPSPARPSLLKDIVQQLQQRSGSLCLVTGEPGQGKTAFLSSLVSALQAP------------------FGATRSSQVFFHFAGARPDQSYILTLLRRLCTYLRHQLQ-----HSKPF--PTTYRGLVWELHTLLPKSAQTLRSGQTLVLVIDGADQLGDQTGRLISDWIPKSLPQKVHLVMSMSTSTGLADILQCRRDAHVVALRSLEPTARAQLVRQELALYGKRLEETPFNNQMRLLLVKRGAALPLYLRLATDHLRLFTLFEQMSEQLRTLPATVPLLLQHVLGVLEQEHEPDILPLALAALQVTRSGLTVDRLHGVISTWRALSSE-------TVDWAEAMAARNKGDPYPMGPFTYLIQSLRRLLGEGSLELPGARLRLPPGPLSSAVELRYRKRPGLKTKAHVLIAVQLWKMCDPEALGTFHNCHPEALNDLPYHLVQSGNHSLLASLLTNLNVTATYLELGLLSQLGEAHALYASSVPMSEP----VSSETDVIAFHTFLKQQSRLLTQYPALLTQQATNQPSNSPIYQQVPKLA----QRWSSQPILRWLNKPQTMGSQQSSSLSLVPSSMPTAVSLSPNGQWAVVATASGIVHLLDTRTWQEEKSIVSGCDGISSCLCPSNSTVFLAAS-DGLLELWDLQGGWRVFQTKAHQLQITDCCLSPDHRLLATVSLDRHLKLWDTVHGKLASQHLSQKPLNCVAFHPEEQV-ITTGNWAGCLSVLRLDSLTVTM-----SSVRAVTFAPSGTVLAASHLDGTVELWAWQKGAQLASFPA-HLGYVASALFLQSGRQMLTAGEDGK----VQMWSGSLGRPKGTLDSLPLSPALSVAISPDRAFVAVGHHSDGIRIYRTSSGTEEGQCPVSDAAVSALAW------LNPKVLVSGGEDGNLQCWMLAYVTPHRLW--LLPAHQKAVLGLATSQELLASASEDFTVRLWSLQFLTQPNLAKKLHPGRELRGHTGPVTCCSFSPDGGILATGSRDQSLLCWDVRMPEAPVVMHSLPACHRDWVTGCSWTKDAMLLSCSNDGSVRLWDPV 2029
BLAST of Telomerase protein component 1 vs. TrEMBL
Match: A0A1S3J9Z1 (telomerase protein component 1 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106171286 PE=4 SV=1) HSP 1 Score: 458.373 bits (1178), Expect = 3.056e-126 Identity = 433/1788 (24.22%), Postives = 807/1788 (45.13%), Query Frame = 1
Query: 814 LSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIELNSINKTKQKTLDRK---------------NKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNET---AIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDS--LVNRFQKNT---KCKSILKMSLDILSDNKKGKITVTDLFDEMVAGRVQFD--MILSFDVS---ISEQCVSQYIK-----YNPSVLIIFNSINPPTETMN----CKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEP-LVKDSPNFPDAIP------NEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDY-EGLSVTNIEYQFA------SKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINNSILSECHGEQTRYKSIMK--------ETLTF--LKSYTENIESFQKDEVNQLLLIVEKKLSFEIDIDSPVNCQSFITPKSTDKNENELLRS--GGILIIDGKPGSGKTSIMSELISQYSEISKLPNRLKFIWIFDVIKFINNEKSXXXXXXXXXXXIIEFLIYNLPFPMKSYLKKELQAHNEINSEEFWRPINIKHAXXXXXXXXXXXXXXXXXYVTIFIDGIDNLRDFSEASTLSWIPLVLPPKFRIIMXXXXXXXXXXXXKFRKNSVIHEIQPISIFHKRKVIENLLKKIGKTLQSNPFDNYMTYFSMKRDSNKPMFLKIAINHMTLNTKYDKVKEEIDNLPSTLENLILYSLKSIEKEIPQEICLVFFSFLNHSKSGFTMKDLQMLMSIYFRV----YIEKNNFLLTANDYNDFKLASNLPLCFSMYPIIYIKNHSAILLDEDKKGRIIIKNSFIGNLITKYSMSIDKTVVHCIISIYC--------DEMLKFDDKFAFRDIIYYKFKSHLYEECCSLLTNIEYLKRRFDLGIAEGLLLDY--NGFEETNSERNKLWFDICNRQTYKDFKTFISENLTFLIENPSFCIQQAINEPLHSCVNVKCNEIKIIPFNFSNTKPVILKKNKAFTYKKDISSLVYYLSD---QISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKST-KSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSN-----EKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIII-------KKVESL--HSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCK-----ELILVGCKDGSXXXXXXXXXXXXNHEI------KAHNDWITTVRF-NSFNYFLSGSNDFTIKLWEII 5856
+LK ++R +HI EPVE+VM L+GK YP T + F+ S+LPG WDE +AGKRMK+PTPETWETQ+S+ GNK E+WQ L+++K LP+MAM+RN+RN++++ I + Y KV + + +V++ + PF++F+AY++L + + ++L+E + + + + +K +NA K K+V ++ RY +AL+TAI+I+T YN+ PI+G +I N+ +T + G + V E+ L+ MC + E +++ + +S L +K T +S+L + + + + + +++ R Q D +ILS +S + Q VS ++K NP++L + + + N + N + I G+++ ++ I+E + ID +DEKY L + +P VK + P I +FISSTF DM ER ++ + P ++ + N ++ DLRWGV +S K L+ C+ +I +C F+GILG R GW+PD V+ + E + ++DY G S+T +E A K Q F L++ KS++ ++ + L DF P + +E + + I +S L G ++ ++ E F L ++ F DE L I + E +++ V+ SF K+ K E LR+ GIL++ GKPG GKTS+++ LISQY + + + FI N I F + L + E+ P + K+ IL + Q + + DG++ L D+ +A +L+WIP +P +M+T+ NS + R++S + ++ + ++ K +V+ N L + KTL F+N M + KR++N P+FL +A + + Y+K+ E++ +LP T+ L+ L +E++ Q + + L ++ G ++L ML+S + ++ Y ++ + + A PL S+ + + S++L + I+ ++ T+ + ++H +++ Y + + ++ AF ++ Y+ + + E +L ++++L+ + LG A LL D+ G + ER++ F ++ +++F+S NL L P+ QQA+NEP S +I+ + + +I KNK + + LSD ++ +A + +++L++L + + H ++ F D ++ S S D +W +G + V+KG+ V+ C K ++I + + D +W+ + V P+NC+ HP ++ G W+ ++ I++ N + A+L + S+ +S+ + P + +++GE+ +W++ NG ++ +S + + +S G ++ S I VWS LG N E + N Q++V G G+ D+ + E + SV VD+ R +I DN + K + SL H+ V+ I + + +GS+D + + ++ + + + + C L++ C+ + + I+ L + I H DW+ + N+ ++ ++ SNDF +KLW+I+
Sbjct: 537 FTLKQLIRKIHITEPVEHVMCLIGKRYPETLEEFYKSRLPGTWDEERAGKRMKLPTPETWETQVSMKGNKAEVWQDLLEHKKLPFMAMLRNLRNMIKAGISEKYTTKVIKRLTDVRSVVNSRQFPFRFFSAYEVLNSLEKEYEQNQKQLVEEAVAGSSSWSRGRGRGRGCGRGGRGGGRGGRWDKKKNA-KTKEVP----FDPPLLNRYRKALDTAIKIATTYNVQPIKGTTVIFCNLGKTMNRPCTAAKGLGKPRQVSEIAVLLGLMCKYSCEESKMVVYGNSSYLEVDLEKGTILDNMQSVLGSAFMVNNQQDTDAVVPDGILRDLLRDRTQVDNLIILSDGMSLESVEGQNVSDFLKKYRRLVNPNMLFVNVDLGGKSSGFNKSVQPEHDNDIFIAGYSDQILRFIAERGESGQLTHIDKIDEKYNLTAKVPGLEKKPYAVKPAVEHPLPIAALKPRWRTARVFISSTFRDMHGERDLLTRFVFPELRARGKQHFLNVYEV---DLRWGVTEEDTRSNKTLELCLTEITKCQFFIGILGERYGWVPDKYVVPDSPE-FDWVRDYPPGCSITELEMHSACMSNPDEKKDQAFFFLRD-----------KSWQKDL----------PKKYLQDFAAESPS-SATKMEAL--KERIRSSGLEVFDGYPCKWGGVVDGQPMVSGLEDFGFRTLNCLWNAVKKFFPDEDAVLDEISHETSQHEAFLEARVS--SFTGRKAQMKMCLERLRTMKEGILMLSGKPGCGKTSLVANLISQYD--ADIGAKTHFIHFVGATPESTN---------------ITFALKRLCTELIRRFGLEMDV-----------PQDYKNLCGELKTILTEASQASGSPLLLVFDGLEMLEDYHQARSLTWIPEEIPENVIFLMSTVENSECHRALSRRQHSSV-QLSGLDLWDKPEVVRNQLARHKKTLVETGFNNQMKLLTSKREANNPLFLNLACEELRVFGVYEKITEKLKSLPHTVPLLLQEVLARLEQDHGQSLVSTALTLLVCARKGLFEEELHMLLSYHQKLQHVKYTVQDVLNVPLEPEHQIPQAVFAPLLRSLKTFLRPEATSSLLSLAHAEIERSIRQRYMRGSSTELEV-----MLHRLLAGYFWLNADPDKNGSWQGSNQRAFSELTYHLSCTGAFSELEDILCSLKFLRAKCMLGQASELLEDFLVKGASSKSQERSRQKF--LSQPRIVQYQSFVSRNLHVLSSVPALTWQQALNEPESS---APAQDIQSLLESVDMDLGLIKWKNKP----EWSDPCLLTLSDFTMPVTCLAISPDGQFFVCGSDDCVVRLYDLNTGKEQRSFTGHSHTISDVCFVGKD-KICSASLDQTLSLWDLNDGHRISVMKGNNRRVSSCSSDAKGSIIVSTAWDCYIKVWQGKDGVEVSKFTDVCPVNCVAFHPEGQL-IVTGSWDASLKIWDTLNKNRKAILRGHSSSVRSVAYSPSGRHIASASLDGEVRLWNAANGTQVGTLSGHTLP-VNKLVFSPAGQELITV----SDDHKIKVWSGHLGQPVNSIGQEEYGAATSVALSRNGQYVVVGYHEGQTRRF-------------DIRSGLLDFEVHHHQASVKCVHCVDH-RESVIITGSADNTALALDPLTGKALFSLTGHTNSVLCIDSRLDWLATGSED-----FQARMFDRKRGGPPYAVLSGHVAPVTGCSFNAEGSLLVTSCRGACLMVWNIQDLFPGDKNIPMNVISACHADWVNGCMWSNTGDFVVTASNDFNLKLWDIL 2220
BLAST of Telomerase protein component 1 vs. Ensembl Cavefish
Match: tep1 (telomerase-associated protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6153]) HSP 1 Score: 214.927 bits (546), Expect = 7.921e-61 Identity = 104/253 (41.11%), Postives = 159/253 (62.85%), Query Frame = 1
Query: 466 DLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSSCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEE 1224
DL +I++ DPEFILKV++Y R+ELNIR +N+L+A++ Y ES+P+L++Y + + LP+DWLEV + +SS LP LKKAL++KFK FS YQL KY +K+ + N KK + YP AF S L G W+ +AG+RMK+ P+TWET++S+ GN +W+KLI+N SLP+MAM+RN+RN++ I D +H ++ + + ++ VI + PF++ +AYK++ E
Sbjct: 141 DLGTEITRRDPEFILKVAVYTRQELNIRITTNFLLALAAYLPESKPHLRRYFCAAVQLPSDWLEVTRLFSTCFSSS-LPACLKKALVDKFKQFSEYQLAKYNTRKLRGKHNKKK--------------------------REYPSDLRAFVSSGLSGVWESERAGQRMKLKQPDTWETKLSLEGNNAAVWEKLINN-SLPFMAMLRNLRNMITQGISDQHHERILKRLTSKNAVIQSRQFPFRFLSAYKVIME 365
BLAST of Telomerase protein component 1 vs. Ensembl Cavefish
Match: ENSAMXT00000041500.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000219.1:314674:321613:-1 gene:ENSAMXG00000037746.1 transcript:ENSAMXT00000041500.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 77.0258 bits (188), Expect = 4.694e-15 Identity = 37/95 (38.95%), Postives = 61/95 (64.21%), Query Frame = 1
Query: 511 KVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLIS-----NSSCLPNQLKKALINKFKDFSIYQLGKYRNKK 780
+V++Y R+ELN +++YL+A++ Y S+P++++Y + + LP+DWL+V Y +S S LP LKK L++KFK FS QL KY ++
Sbjct: 52 EVAVYSRQELNKHLMASYLIALAAYLPASKPHVRRYFCAAVRLPSDWLQVPRIYSTVSWRISHQLSSLPTCLKKGLVDKFKQFSESQLAKYCTRR 146
BLAST of Telomerase protein component 1 vs. Ensembl Cavefish
Match: ENSAMXT00000044252.1 (pep primary_assembly:Astyanax_mexicanus-2.0:1:2462631:2463659:1 gene:ENSAMXG00000035043.1 transcript:ENSAMXT00000044252.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 62.7734 bits (151), Expect = 1.014e-10 Identity = 33/109 (30.28%), Postives = 56/109 (51.38%), Query Frame = 1
Query: 2071 INIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSV 2397
+ +FISSTF DM ER ++ + P ++R +C+ + ++LRWGV +S + +Q C+ ++ R + + ILG R G +P + PEL Y + V
Sbjct: 43 VRVFISSTFRDMHAERDVLVRSVFPELRRRA---APHCLYLQEVELRWGVTEE--ESNQAIQLCLSEVCRSQLLLSILGERYGQVPPRPTL-------PELPQYTWVRV 139
BLAST of Telomerase protein component 1 vs. Ensembl Cavefish
Match: taf5 (TATA-box binding protein associated factor 5 [Source:NCBI gene;Acc:103038729]) HSP 1 Score: 56.225 bits (134), Expect = 4.272e-7 Identity = 43/204 (21.08%), Postives = 91/204 (44.61%), Query Frame = 1
Query: 4474 LVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKT-KSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKST-KSIVFHPYYDLFLTTTINGEINVWSS 5079
++Y S + V+F N + S E G I+L++L+ F L+ + H V T F +S D +A +W++ L++ GHL +T +N + T S D +W ++L K PI+ + PN + + G +G + ++++ + + L + T ++ F ++ + +++ + +W +
Sbjct: 466 ILYGHSGPVYGVSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRMFAGHLADITCTRFHPNSNYVATGSADRTIRLWDVLNGHCVRVLTGHKGPIHSLAFSPNGKY-LASGSTDGRVLLWDIGHGLMIGELKGHTDTIYALRFSRDGEILASGSMDNTVRLWDA 668 HSP 2 Score: 53.9138 bits (128), Expect = 2.496e-6 Identity = 62/294 (21.09%), Postives = 120/294 (40.82%), Query Frame = 1
Query: 4495 QISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTK-SPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKST-KSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDA------NDQFIVCGTKFGE-ISILNSNFTNK 5349
++ V + L +I + L ++ + K L H V F + L+S SEDG +WS L KGH PV D S + D +W T+ + ++ + I C HPN+++ V G + + ++++ N V VL +K S+ F P + + +G + +W +G+ + + Y+ +++S DG ++ G+ + + +W ++ E D D T N Q ++ GT + +++ +FT +
Sbjct: 431 KLRKVKSAADLGMIDKESDDVLERIMDEKTASECKILYGHSGPVYGVSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRMFAGHLADITCTRFHPNSNY-VATGSADRTIRLWDVLNGHCVRVLTGHKGPIHSLAFSPNGKYLASGSTDGRVLLWDIGHGLMIGELKGHTDTIYA-LRFSRDG-EILASGSMDNT---VRLWDAIRAFDDVETD--DFTAATGHVHLPDNSQELLLGTYLSKSTPVIHLHFTRR 716
BLAST of Telomerase protein component 1 vs. Ensembl Cavefish
Match: taf5 (TATA-box binding protein associated factor 5 [Source:NCBI gene;Acc:103038729]) HSP 1 Score: 56.225 bits (134), Expect = 4.272e-7 Identity = 43/204 (21.08%), Postives = 91/204 (44.61%), Query Frame = 1
Query: 4474 LVYYLSDQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKT-KSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKST-KSIVFHPYYDLFLTTTINGEINVWSS 5079
++Y S + V+F N + S E G I+L++L+ F L+ + H V T F +S D +A +W++ L++ GHL +T +N + T S D +W ++L K PI+ + PN + + G +G + ++++ + + L + T ++ F ++ + +++ + +W +
Sbjct: 466 ILYGHSGPVYGVSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRMFAGHLADITCTRFHPNSNYVATGSADRTIRLWDVLNGHCVRVLTGHKGPIHSLAFSPNGKY-LASGSTDGRVLLWDIGHGLMIGELKGHTDTIYALRFSRDGEILASGSMDNTVRLWDA 668 HSP 2 Score: 53.9138 bits (128), Expect = 2.496e-6 Identity = 62/294 (21.09%), Postives = 120/294 (40.82%), Query Frame = 1
Query: 4495 QISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTK-SPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKST-KSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDA------NDQFIVCGTKFGE-ISILNSNFTNK 5349
++ V + L +I + L ++ + K L H V F + L+S SEDG +WS L KGH PV D S + D +W T+ + ++ + I C HPN+++ V G + + ++++ N V VL +K S+ F P + + +G + +W +G+ + + Y+ +++S DG ++ G+ + + +W ++ E D D T N Q ++ GT + +++ +FT +
Sbjct: 431 KLRKVKSAADLGMIDKESDDVLERIMDEKTASECKILYGHSGPVYGVSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRMFAGHLADITCTRFHPNSNY-VATGSADRTIRLWDVLNGHCVRVLTGHKGPIHSLAFSPNGKYLASGSTDGRVLLWDIGHGLMIGELKGHTDTIYA-LRFSRDG-EILASGSMDNT---VRLWDAIRAFDDVETD--DFTAATGHVHLPDNSQELLLGTYLSKSTPVIHLHFTRR 716
BLAST of Telomerase protein component 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010121.1 (pep scaffold:Pmarinus_7.0:GL485934:2276:4067:1 gene:ENSPMAG00000009162.1 transcript:ENSPMAT00000010121.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 87.0409 bits (214), Expect = 6.533e-20 Identity = 43/105 (40.95%), Postives = 65/105 (61.90%), Query Frame = 1
Query: 478 DISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSS-----CLPNQLKKALINKFKDFSIYQLGKYRNK 777
++++ DPEF+LKV+LY R+EL IR SN L+A++ RP+L +Y + + LP+DWL+V Y NS LP L++AL+ KF F+ +QL KY +
Sbjct: 32 ELAQTDPEFVLKVALYSRRELGIRKTSNVLLALAAELPPCRPHLVRYFSAAVVLPSDWLDVATTYKSPPNSCTRERLSLPACLRRALVEKFPAFNEHQLAKYNKE 136
BLAST of Telomerase protein component 1 vs. Ensembl Yeast
Match: TAF5 (Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification [Source:SGD;Acc:S000000402]) HSP 1 Score: 59.3066 bits (142), Expect = 6.902e-9 Identity = 53/203 (26.11%), Postives = 85/203 (41.87%), Query Frame = 1
Query: 4612 HFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTK-SPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAV-LHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVW 5214
H V T F ++ L+S SED +WS L KGH PV D S + T S D +W + +I + ++C++ HPN + V G + +++++ V + L + SI P T + +G INVW G +LK + KN ++ YS +G + GA + + VW
Sbjct: 524 HSGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCY-VFTGSSDKTCRMWDVSTGDSVRLFLGHTAPVISIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSKEGNVLISGGADHT----VRVW 721
BLAST of Telomerase protein component 1 vs. Ensembl Nematostella
Match: EDO32895 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STP2]) HSP 1 Score: 67.3958 bits (163), Expect = 5.385e-11 Identity = 46/144 (31.94%), Postives = 75/144 (52.08%), Query Frame = 1
Query: 2071 INIFISSTFMDMEKERSIINTIIIPSVK---RNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCH------IFVGILGSRSGWIPD-SKVIRNLSEIYPELKDYEGLSVTNIEY---QFASKNCQKIFLLKNSR 2463
I +F+SSTF D +ER ++ I P ++ L++ C DLRWGVP +E+ ++ C+E+I RC+ F+ + RSGWIPD + NL+ Y + GLS+T +E F N +F++++S+
Sbjct: 31 IRLFVSSTFRDFHEEREVLVKEIFPDLRLWCEERKLHLVEC------DLRWGVPKD-SSTEETVRICLEEIDRCYRDNVMPYFLNLTCGRSGWIPDFGDLTYNLAVQYGWVY---GLSITEMEIVHGAFRKCNPNALFMIRDSK 164
BLAST of Telomerase protein component 1 vs. Ensembl Nematostella
Match: EDO39396 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA50]) HSP 1 Score: 56.9954 bits (136), Expect = 6.861e-8 Identity = 86/380 (22.63%), Postives = 151/380 (39.74%), Query Frame = 1
Query: 2071 INIFISSTFMDMEKERSIINTIIIPSVK-----RNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCH-------IFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGL---SVTNIEYQFAS---KNCQKIFLLKNSRDEDLDNLQLKSFRDNIIAXXXXXXXXXXXVLNDFKILIPCLNKIILEKINFQNEINNSILSECHGEQTRYKSIMKET------LTFLKSYTENIESFQKDEVNQLLLIVEKKLSFEIDIDSPVNCQSFITPKS-----------------TDKNE---NELLRSGGILIIDGKPGSGKTSIMSELISQYSEISKL---------P---------NRLKFIWIFDVIKFINN 3024
+ +F+SSTF D ER ++ + P ++ R + L I C DLRWGVP + +E ++ C+ +I +C F+ +LG R GW+P + N EI K Y+ + S+T++E A+ KN F++++ +F D I + D +L +++ EK+ + + Y I K T L L + + K + +VEK+L+ E ++ + SF+ + T ++E NE S I+++ G PGSGK+S+++ + ++ L P NRL F W+ D+ + N
Sbjct: 42 VRLFVSSTFTDYHAERELLVKKVFPELREWCEHRRVQL-------IEC-DLRWGVP-KYSSTEMTIKTCLGEIDKCKEETDGVPFFLNMLGERYGWMPGESDVPN--EIQ---KGYDWVFPASITHMEILHAAYRNKNPNAAFMIRDP-----------AFLDEI-------PTDMKGAFIDNSVLSKAQLQMLKEKLRLR------FPGQVFDYNCEYTGIDKSTGKPKVCLRALDDFGNRVLEVFKAAIEMTFPVVEKELTLE-QTEAAAH-DSFVRSRGALLLGRHNEVKQVMEYITREHEPLGNEESDSRPIMLVQGVPGSGKSSLVAYCTLEAKKLDSLLFYHFVGSGPGSTSPLRVVNRL-FAWLRDITHYTGN 380
BLAST of Telomerase protein component 1 vs. Ensembl Nematostella
Match: EDO34865 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SN68]) HSP 1 Score: 56.6102 bits (135), Expect = 8.744e-8 Identity = 32/112 (28.57%), Postives = 53/112 (47.32%), Query Frame = 1
Query: 4492 DQISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWK 4827
D++ VAF LI+ + G +++N L L H ++K F TRL++ S D A +W G L+VL+GH + C + ++I T S D+ +W+
Sbjct: 304 DEVLDVAFDYTGQLIATASADGTGRVYNALTHHCLSKLEGHEGEISKITFNAQGTRLLTASSDKTARLWDPNTGKCLQVLEGHTDEIFSCAFNYDGDIIITGSKDNTCRLWR 415
BLAST of Telomerase protein component 1 vs. Ensembl Nematostella
Match: EDO31974 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWE8]) HSP 1 Score: 56.6102 bits (135), Expect = 9.856e-8 Identity = 47/196 (23.98%), Postives = 77/196 (39.29%), Query Frame = 1
Query: 4513 FGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVS-TKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVG-----CWN---GNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVW 5073
F S L+ E GLIQLF+L L + H V+ T F ++ ++S S+D L W K H V + S +++ T S D MW L +P+ CI +PN + G W+ G + + +N++ K+ S+ F Y L+ +I+ + V+
Sbjct: 89 FRSDGQLMIAGGEDGLIQLFDLNSRAVLRQFKGHSGPVHVTKFLQDNLHIVSASDDKLVNCWDIATEQTTATYKEHEDYVRTGVASQVTSDIFLTGSYDHTVRMWDRRCNASVNTLDHGAPVECIQVYPNGAMAITAGENVIKIWDILSGGRLVTSFSNHQ--------KTITSLCFDGAYKRLLSGSIDRNVKVY 276
BLAST of Telomerase protein component 1 vs. Ensembl Nematostella
Match: EDO37328 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG41]) HSP 1 Score: 54.6842 bits (130), Expect = 1.083e-7 Identity = 52/249 (20.88%), Postives = 102/249 (40.96%), Query Frame = 1
Query: 4495 QISHVAFGSILNLISMSYESGLIQLFNLKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPI--NCITSHPNNDFKVIVGCWNGNMFIYNL-NNYKKVAVLHNNKS-TKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLG 5229
Q++ AF + + L+++++ K + L L HH + F ++ S + D L +VW + G + L+GH V C S + + S D+ I+W + + +L + C SH + V G W+ + +++L V L +KS S+ F + + + + + I +W S G + +++ + + +S G + A S + VW T+ G
Sbjct: 1 QVNTCAFSPDWTRVVTGGDDDLVKIWDSKTGKVLFTLEHHDGAIKCVCFSSDGKLFASAAYDHLVMVWEAATGKQVFCLQGHTHSVETCCFSPNGAFLCSGSWDNTAIIWSLKNGMPTYVLNKHRNVIQTCAFSHDSK--TVATGSWDCTVRLWHLVEGDMAVKCLDGHKSNVHSLAFAKNH-MLASGSWDMTIRLWDSKTGELIHLLT-GHSGWVQACSFSGSG----DLLASASDDQTVRVWDTSTG 241
BLAST of Telomerase protein component 1 vs. Ensembl Medaka
Match: ENSORLT00000046678.1 (pep primary_assembly:ASM223467v1:17:3383455:3390573:1 gene:ENSORLG00000027023.1 transcript:ENSORLT00000046678.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 81.6481 bits (200), Expect = 5.809e-16 Identity = 42/103 (40.78%), Postives = 66/103 (64.08%), Query Frame = 1
Query: 508 LKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLIS---NSSCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKK 807
++V++Y R+ELNIR +N+L+A++ ++ ++++Y + + LP+DWLEVV Y +S LP LKKA+ +KFK FS YQL KY +K + N KK
Sbjct: 151 VQVAVYTRQELNIRITANFLLALAASLPSTKRHVRRYFCAAVQLPSDWLEVVRIYSAVSVRERLCSLPACLKKAMADKFKQFSEYQLAKYNTRKHRCKHNKKK 253
BLAST of Telomerase protein component 1 vs. Ensembl Medaka
Match: wdr13 (WD repeat domain 13 [Source:NCBI gene;Acc:101170185]) HSP 1 Score: 55.4546 bits (132), Expect = 5.065e-7 Identity = 51/196 (26.02%), Postives = 87/196 (44.39%), Query Frame = 1
Query: 4432 KKNKAFTYKKDISSLVYYLSDQISHVAF-----GSILNLISMSYESGLIQLFNLKQFEALLNLRHHF-----SRVNKTFFYNNDTRLISVS--EDGLALVWSSIEGALLKV-LKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTE--KFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKV 4974
+ A +++ +S Y L Q++ + GS++ + L + A + H F S V + F N+D L++ + L+++ S A +KV LKGH GPVTD S ++I + SLD +W TE + + E S + C T P N+ +VG ++ + N++ KKV
Sbjct: 19 RAQGARGHRRSVSRGSYQLQAQMNRAVYDERPPGSLVPTSVAEASRAMAGDTTLSENYAFAGMHHIFDQHVDSAVPRLQFANDDKHLLACCSLDATLSIMMLSPPPASVKVILKGHGGPVTDFAWSLSNDIIVSTSLDGTLRIWNTEDGRCIREVRDPESSELLCCTFQPMNNNLTVVGNGKNHLQVVNISTGKKV 214
BLAST of Telomerase protein component 1 vs. Ensembl Medaka
Match: wdr13 (WD repeat domain 13 [Source:NCBI gene;Acc:101170185]) HSP 1 Score: 55.4546 bits (132), Expect = 6.565e-7 Identity = 51/196 (26.02%), Postives = 87/196 (44.39%), Query Frame = 1
Query: 4432 KKNKAFTYKKDISSLVYYLSDQISHVAF-----GSILNLISMSYESGLIQLFNLKQFEALLNLRHHF-----SRVNKTFFYNNDTRLISVS--EDGLALVWSSIEGALLKV-LKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTE--KFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKV 4974
+ A +++ +S Y L Q++ + GS++ + L + A + H F S V + F N+D L++ + L+++ S A +KV LKGH GPVTD S ++I + SLD +W TE + + E S + C T P N+ +VG ++ + N++ KKV
Sbjct: 98 RAQGARGHRRSVSRGSYQLQAQMNRAVYDERPPGSLVPTSVAEASRAMAGDTTLSENYAFAGMHHIFDQHVDSAVPRLQFANDDKHLLACCSLDATLSIMMLSPPPASVKVILKGHGGPVTDFAWSLSNDIIVSTSLDGTLRIWNTEDGRCIREVRDPESSELLCCTFQPMNNNLTVVGNGKNHLQVVNISTGKKV 293
BLAST of Telomerase protein component 1 vs. Ensembl Medaka
Match: wdr13 (WD repeat domain 13 [Source:NCBI gene;Acc:101170185]) HSP 1 Score: 55.4546 bits (132), Expect = 6.565e-7 Identity = 51/196 (26.02%), Postives = 87/196 (44.39%), Query Frame = 1
Query: 4432 KKNKAFTYKKDISSLVYYLSDQISHVAF-----GSILNLISMSYESGLIQLFNLKQFEALLNLRHHF-----SRVNKTFFYNNDTRLISVS--EDGLALVWSSIEGALLKV-LKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTE--KFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKV 4974
+ A +++ +S Y L Q++ + GS++ + L + A + H F S V + F N+D L++ + L+++ S A +KV LKGH GPVTD S ++I + SLD +W TE + + E S + C T P N+ +VG ++ + N++ KKV
Sbjct: 98 RAQGARGHRRSVSRGSYQLQAQMNRAVYDERPPGSLVPTSVAEASRAMAGDTTLSENYAFAGMHHIFDQHVDSAVPRLQFANDDKHLLACCSLDATLSIMMLSPPPASVKVILKGHGGPVTDFAWSLSNDIIVSTSLDGTLRIWNTEDGRCIREVRDPESSELLCCTFQPMNNNLTVVGNGKNHLQVVNISTGKKV 293
BLAST of Telomerase protein component 1 vs. Ensembl Medaka
Match: phip (pleckstrin homology domain interacting protein [Source:NCBI gene;Acc:101175120]) HSP 1 Score: 55.4546 bits (132), Expect = 6.716e-7 Identity = 36/138 (26.09%), Postives = 59/138 (42.75%), Query Frame = 1
Query: 4507 VAFGSILNLISMSYESGLIQLFNLKQFEALLNLRH---------HFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSH 4893
V +GS N++ S+ GL + L+Q +H H S V F R+ + S+D L +W + +G LL L+GH ++D VS + +I S D +W L+T +P+ + H
Sbjct: 109 VIYGSPPNIVETSHSRGLNGAYRLRQLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWGTDDGRLLATLRGHAAEISDMAVSYENTMIAAGSCDKTIRVW---------CLQTCAPLAVLEGH 237
BLAST of Telomerase protein component 1 vs. Planmine SMEST
Match: SMESG000032828.1 (SMESG000032828.1) HSP 1 Score: 1450.65 bits (3754), Expect = 0.000e+0 Identity = 739/842 (87.77%), Postives = 746/842 (88.60%), Query Frame = 1
Query: 34 MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSSCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSENIIKRYTEALNTAIEISTLYNIPPIRGKILILANVNETAIYSPFKYGSSKSVKEVIALVTSMCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDEMVAGRVQFDMILSFDVSISEQCVSQYIKYNPSVLIIFNSI--------------NPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA 2517
MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNS CLPNQLKKALINKFKDFSIYQLGKYR KKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILK NEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVS+ + +I T A E + +Y LVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDEMVAGRVQFDMILSFDV+ISEQCVSQYIKYNPSVLIIFNSI +PPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA
Sbjct: 1 MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSCCLPNQLKKALINKFKDFSIYQLGKYR----------KKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKANEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSE----VKEVIALVTSMCYVASEATEIY-----------------------------------------------------LVKDSLVNRFQKNTKCKSILKMSLDILSDNKKGKITVTDLFDEMVAGRVQFDMILSFDVNISEQCVSQYIKYNPSVLIIFNSIKFLFISYNFTIFSFSPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA 775
BLAST of Telomerase protein component 1 vs. Planmine SMEST
Match: SMESG000032835.1 (SMESG000032835.1) HSP 1 Score: 965.681 bits (2495), Expect = 0.000e+0 Identity = 495/511 (96.87%), Postives = 499/511 (97.65%), Query Frame = 1
Query: 4576 LKQFEALLNLRHHFSRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSXXXXXXXXXXXXNHEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNFLSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKFL 6108
LK F + ++ VNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKN EVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSIGLIKIKKLLLLNHEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNF+SSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTK L
Sbjct: 185 LKSFRDNIIANEYYYEVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNSEVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSIGLIKIKKLLLLNHEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNFVSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKNL 695 HSP 2 Score: 342.813 bits (878), Expect = 2.150e-99 Identity = 162/167 (97.01%), Postives = 165/167 (98.80%), Query Frame = 1
Query: 2017 CEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA 2517
C+ ++K SPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA
Sbjct: 28 CKSILKMSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA 194 HSP 3 Score: 319.701 bits (818), Expect = 1.374e-91 Identity = 193/315 (61.27%), Postives = 212/315 (67.30%), Query Frame = 1
Query: 5917 HVIGNHTGPITSISINSDDNFLSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKFLSTDYLLVVNARSVLYGLDFKKSCLINKISEHHEPIISV-FDSQNELFTISVDGAVRKSSFHQIF---------------------QKNLKQHNNFKITHSIHFSSIMNFSDFIVALSDSGKLLLFYKNNPNDNWGLCKEFDVKAHYTKYNTQEFQTPFLQCSYFKKCGKHEVIMKICKSVFIFDLESLLFINFNGHVKDVVEDFDSLDFNIHXXXXXXXXXXXXQNSDQKYFIRFIEKGHILELLSMKNNE 6795
H I H IT++ NS + FLS S D TIKLW + + +D F + K +++ I H PI S+ +S + + S DG ++ + +F KNLKQHNNFKITHSIHFSSIMNFSDFIVALSDSGKLLLFYKNNPNDNWGLCKEFDVKAHYTKYNTQEFQTPFLQCSYFKKCGKHEVIMKICKSVFIFDLESLLFINFNGHVKDVVEDFDSLDFNIHELIETESTLEILQN+DQKY IRFIEKGHILELLSMKNNE
Sbjct: 576 HEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEI--ILMDTSNTNATFENS-------------------------------AKFNVLHVIGNHTGPITSISINSDDNFVSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKNLKQHNNFKITHSIHFSSIMNFSDFIVALSDSGKLLLFYKNNPNDNWGLCKEFDVKAHYTKYNTQEFQTPFLQCSYFKKCGKHEVIMKICKSVFIFDLESLLFINFNGHVKDVVEDFDSLDFNIHELIETESTLEILQNNDQKYSIRFIEKGHILELLSMKNNE 857 HSP 4 Score: 73.9442 bits (180), Expect = 1.363e-12 Identity = 35/35 (100.00%), Postives = 35/35 (100.00%), Query Frame = 1
Query: 1561 MCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMS 1665
MCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMS
Sbjct: 1 MCYVASEATEIYLVKDSLVNRFQKNTKCKSILKMS 35
BLAST of Telomerase protein component 1 vs. Planmine SMEST
Match: SMESG000032835.1 (SMESG000032835.1) HSP 1 Score: 964.911 bits (2493), Expect = 0.000e+0 Identity = 494/497 (99.40%), Postives = 495/497 (99.60%), Query Frame = 1
Query: 4618 SRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNYEVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSXXXXXXXXXXXXNHEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNFLSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKFL 6108
SRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKN EVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSIGLIKIKKLLLLNHEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNF+SSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTK L
Sbjct: 119 SRVNKTFFYNNDTRLISVSEDGLALVWSSIEGALLKVLKGHLGPVTDCIVSTKANLIGTVSLDSQFIMWKTEKFVLEKILKTKSPINCITSHPNNDFKVIVGCWNGNMFIYNLNNYKKVAVLHNNKSTKSIVFHPYYDLFLTTTINGEINVWSSTNGMKLKVISMENKNYYSNVQYSSDGLQVFEFGAFRSPFFGINVWSTTLGYNSNEKDLLDITCVDANDQFIVCGTKFGEISILNSNFTNKLQKTICDVALTSICLEKSNKPLSVTFFVTVDYERNFYLIQMIEDNIIIKKVESLHSRPVIVIYLLPNCIISGSDDCSIGLLKFKNSEVTEKLQLFNIFLDSILTIDVCKELILVGCKDGSIGLIKIKKLLLLNHEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEIILMDTSNTNATFENSAKFNVLHVIGNHTGPITSISINSDDNFVSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKNL 615 HSP 2 Score: 319.701 bits (818), Expect = 2.870e-92 Identity = 193/315 (61.27%), Postives = 212/315 (67.30%), Query Frame = 1
Query: 5917 HVIGNHTGPITSISINSDDNFLSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKFLSTDYLLVVNARSVLYGLDFKKSCLINKISEHHEPIISV-FDSQNELFTISVDGAVRKSSFHQIF---------------------QKNLKQHNNFKITHSIHFSSIMNFSDFIVALSDSGKLLLFYKNNPNDNWGLCKEFDVKAHYTKYNTQEFQTPFLQCSYFKKCGKHEVIMKICKSVFIFDLESLLFINFNGHVKDVVEDFDSLDFNIHXXXXXXXXXXXXQNSDQKYFIRFIEKGHILELLSMKNNE 6795
H I H IT++ NS + FLS S D TIKLW + + +D F + K +++ I H PI S+ +S + + S DG ++ + +F KNLKQHNNFKITHSIHFSSIMNFSDFIVALSDSGKLLLFYKNNPNDNWGLCKEFDVKAHYTKYNTQEFQTPFLQCSYFKKCGKHEVIMKICKSVFIFDLESLLFINFNGHVKDVVEDFDSLDFNIHELIETESTLEILQN+DQKY IRFIEKGHILELLSMKNNE
Sbjct: 496 HEIKAHNDWITTVRFNSFNYFLSGSNDFTIKLWEI--ILMDTSNTNATFENS-------------------------------AKFNVLHVIGNHTGPITSISINSDDNFVSSSQDGTIKLWNMKGVFLDNLIVEKDFSSDEEIIPIKWTKNLKQHNNFKITHSIHFSSIMNFSDFIVALSDSGKLLLFYKNNPNDNWGLCKEFDVKAHYTKYNTQEFQTPFLQCSYFKKCGKHEVIMKICKSVFIFDLESLLFINFNGHVKDVVEDFDSLDFNIHELIETESTLEILQNNDQKYSIRFIEKGHILELLSMKNNE 777 HSP 3 Score: 255.373 bits (651), Expect = 1.403e-70 Identity = 120/120 (100.00%), Postives = 120/120 (100.00%), Query Frame = 1
Query: 2104 MEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSR 2463
MEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSR
Sbjct: 1 MEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSR 120
BLAST of Telomerase protein component 1 vs. Planmine SMEST
Match: SMESG000032828.1 (SMESG000032828.1) HSP 1 Score: 867.455 bits (2240), Expect = 0.000e+0 Identity = 430/442 (97.29%), Postives = 431/442 (97.51%), Query Frame = 1
Query: 34 MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSSCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQ 1359
MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNS CLPNQLKKALINKFKDFSIYQLGKY I GKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILK NEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVS+
Sbjct: 1 MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSCCLPNQLKKALINKFKDFSIYQLGKYL-------ILGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKANEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSE 435
BLAST of Telomerase protein component 1 vs. Planmine SMEST
Match: SMESG000032828.1 (SMESG000032828.1) HSP 1 Score: 864.374 bits (2232), Expect = 0.000e+0 Identity = 431/448 (96.21%), Postives = 435/448 (97.10%), Query Frame = 1
Query: 34 MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSSCLPNQLKKALINKFKDFSIYQLGKYRNKKMVAEINGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKTNEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSQRSVVSE 1377
MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNS CLPNQLKKALINKFKDFSIYQLGKY I GKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILK NEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVS++ V++
Sbjct: 1 MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVFHNLINNKSILNPNENLSKNNVSVDEWMNLDVVDDFQSSDNLVISDSNLLRHKSPNCVIGNANRYLTNTNTFKVNLTNLVMNSLPYGINNLSKMDLYVDISKEDPEFILKVSLYCRKELNIRSISNYLVAVSVYSNESRPYLKKYLQSIINLPTDWLEVVYHYMLISNSCCLPNQLKKALINKFKDFSIYQLGKYL-------ILGKKIKLSLKNMVRILHICEPVENVMSLLGKNYPLTQDAFFISKLPGQWDESKAGKRMKIPTPETWETQISIYGNKPEIWQKLIDNKSLPYMAMVRNIRNLLQSNIKDHYHLKVAQNIEKESNVIHGKLLPFQYFTAYKILEEFNETILKANEKLIEIELNSINKTKQKTLDRKNKVRNAIKLKKVSEKITVTD 441 HSP 2 Score: 563.533 bits (1451), Expect = 3.296e-178 Identity = 273/274 (99.64%), Postives = 274/274 (100.00%), Query Frame = 1
Query: 1696 KITVTDLFDEMVAGRVQFDMILSFDVSISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA 2517
KITVTDLFDEMVAGRVQFDMILSFDV+ISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA
Sbjct: 436 KITVTDLFDEMVAGRVQFDMILSFDVNISEQCVSQYIKYNPSVLIIFNSINPPTETMNCKSSNIVRIDGFNEHTIKIISEFNSGSIIKKIDFMDEKYGLKNIEELINCEPLVKDSPNFPDAIPNEINIFISSTFMDMEKERSIINTIIIPSVKRNILLNVTNCIDINCIDLRWGVPIHWGQSEKLLQYCIEQIKRCHIFVGILGSRSGWIPDSKVIRNLSEIYPELKDYEGLSVTNIEYQFASKNCQKIFLLKNSRDEDLDNLQLKSFRDNIIA 709 The following BLAST results are available for this feature:
BLAST of Telomerase protein component 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Telomerase protein component 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Telomerase protein component 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Telomerase protein component 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Telomerase protein component 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Telomerase protein component 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Telomerase protein component 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003493 ID=SMED30003493|Name=Telomerase protein component 1|organism=Schmidtea mediterranea sexual|type=transcript|length=6988bpback to top protein sequence of SMED30003493-orf-1 >SMED30003493-orf-1 ID=SMED30003493-orf-1|Name=SMED30003493-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=2303bp MSTTYKGKLYFTERDLTTRYDKAKIKTYRYEIGKSSPLWLSNFSFNKTCVback to top Annotated Terms
The following terms have been associated with this transcript:
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