Otoferlin
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003490 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 13Note: Hover over icons to view figure legend
Homology
BLAST of Otoferlin vs. Ensembl Human
Match: OTOF (otoferlin [Source:HGNC Symbol;Acc:HGNC:8515]) HSP 1 Score: 860.907 bits (2223), Expect = 0.000e+0 Identity = 478/1306 (36.60%), Postives = 738/1306 (56.51%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF--------------------------ENPITDRKLSDADDISIDSHGMGSDKRTLIDPQT-GEIGEFNYGQTDNESIESGE----DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV-------PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L R DRI K+ FR ++V+ +D F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ + + LID N++II+ ++ E+ Y + D + W +F P ++ A + +G ++ +PQ E D+ +I G+ D S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI SG KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RLL+ + ++ + + L + +V PIS+ GK E F L GAF EAS+ID G K PI FE+++G GN +D E +EEE ++ + + G+ + S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +A+ + + + +L+ C+ ++KL L PQ+ +PDIFIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q ++++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDK--PITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASV-----SSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP-------------------------------------PINGPVDVDRGP--------IMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1232 HSP 2 Score: 646.351 bits (1666), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 425/598 (71.07%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLM--LYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVR+YV+RA DLHPAD NGK+DPY+ +RLG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCK+ D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVIIWNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD++F+ F+NPLKS+KYLIC ++KW +IK ++ L +L LF+Y+ PGY+ K++LGA Sbjct: 1405 IDELKVYPKELE--SEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHF-GPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1997
BLAST of Otoferlin vs. Ensembl Human
Match: OTOF (otoferlin [Source:HGNC Symbol;Acc:HGNC:8515]) HSP 1 Score: 860.522 bits (2222), Expect = 0.000e+0 Identity = 478/1306 (36.60%), Postives = 738/1306 (56.51%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF--------------------------ENPITDRKLSDADDISIDSHGMGSDKRTLIDPQT-GEIGEFNYGQTDNESIESGE----DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV-------PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L R DRI K+ FR ++V+ +D F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ + + LID N++II+ ++ E+ Y + D + W +F P ++ A + +G ++ +PQ E D+ +I G+ D S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI SG KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RLL+ + ++ + + L + +V PIS+ GK E F L GAF EAS+ID G K PI FE+++G GN +D E +EEE ++ + + G+ + S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +A+ + + + +L+ C+ ++KL L PQ+ +PDIFIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q ++++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDK--PITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASV-----SSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP-------------------------------------PINGPVDVDRGP--------IMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1232 HSP 2 Score: 637.106 bits (1642), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 424/598 (70.90%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLM--LYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVR+YV+RA DLHPAD NGK+DPY+ +RLG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCK+ D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVIIWNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD+SF+ F+NPLKS +Y + + ++W L+K L++ LL LL LF+Y+ PGYL K++LGA Sbjct: 1405 IDELKVYPKELE--SEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHF-GPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1997
BLAST of Otoferlin vs. Ensembl Human
Match: FER1L6 (fer-1 like family member 6 [Source:HGNC Symbol;Acc:HGNC:28065]) HSP 1 Score: 698.353 bits (1801), Expect = 0.000e+0 Identity = 411/1157 (35.52%), Postives = 628/1157 (54.28%), Query Frame = 3 Query: 669 AATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVL---RSESGGLPAGAKVYSVP----------------PISDGTCG-------------------------KKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS--------EANEEEEKEVPSVNQGN---RPKIPKWCHSTTEPMLP--DTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAI--RLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK------------GKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAI 3908 +A+ R + +H +++++QI+IT+ EARQL G NI+P++ + IG++ K + V+ TNSP+YN+Y F+F + LFD++I++ +L+ LIG F++D+ TVYN P H F +KWA+L DP DI +G KGY+K D+++MGKG+ +K PK+ + +E IE NLL+P +R A V++YKAE LP+MN+ IMA + A GDSK LVDPFV+VSFAG GRT V+KN P W+E+++F EMFP LC R+++ V+D ++ + +ATH+IDL +I NE GD GFLPTFGP+W+NLYG+PRN++ +M +E+N G GEGV++RGR+L+ I + R++ K +P DG K E FLL GAF+EA++ID +IG K PI FE+S+G GN +D A EE +P +++G +P STT P P ++ Y +L F KKPC+Y IS D R N+LEK+ + ++E + EL + +MK L FI + ++ + + +T LDK+R+ L LE M +AK + Q K L++ + E + ++K+ L+ PQ+ +PD+FIW++ + +R+A+ARI ++++LYS + + G ++ T FL+ PG+ P+GW++Q ++ +YLWLG ++ LP+GY S+ PP ++Y E+ FQLRAHM+ AR LI +D +GLSD FA++ H TTK++ +TLSP W+Q L+ + ++ + + +PP++VVE++D D + GK E+LG P V L +++Y+ PRL + I+ G ++ G+LLA FEL+QV P +G+Q + P E +T + PVP IRP L YRVE LFWGVREM++VQL+SVD+P+ IE G + S VI S K PNFS ++ LPEN L PPL I D R FGR+ L+G + I+ + +++ K G P + + + SS ++ + P D I + Sbjct: 60 SASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFH------HKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKT------SDTEEPIEKNLLIPNGFPL--ERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHS---LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFFEATMIDRKIGDK--PISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQ-QKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGK---RPAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAV--------GKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPP-------SGLQGL-------------------------------------PPVEPPDITQ----IYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYV 1137 HSP 2 Score: 555.058 bits (1429), Expect = 1.480e-163 Identity = 282/591 (47.72%), Postives = 396/591 (67.01%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD-NRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEI-EEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 ++Y LE EF F +++TF L +G+ +D+ D +R++G FKG+ IYK + + +L + + +P N PV +L+R+Y++ A +L PADP+GKSDPY++++LG I +++ YIPKQLNP+FG+ FE+ FP+ES L I + D D++ DD+IGETKIDLENR+YSKH+A+CGL +E GYN WRD PT +L KLCK+ D P + K+ + F EED E +S E LAL+V+ +W +P GC LVPEH+ETRPL++ +KPG++QG L+MW+DMFPK++ P P+DI+PR+P YELRV IWNTEDVIL D + TG+KSSDI+VKGW+KGL D Q TDVHY SL+GEGNFNWRF+F F Y+ AE ++V +++ F++++ E K+P L LQVWD + +++DDFLG LE+ L+ PR AKS + C L + + ISIF+ KR RGWWPF+ K ++ GK++AEF L++ EE E PVG R EP L PNRPD+SF FM+P K L YLI +K ++I A I+ L+ LVLFIY PG +++R++ Sbjct: 1277 LQIYDGDLE--SEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSG--QLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPFS-------KSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854
BLAST of Otoferlin vs. Ensembl Human
Match: OTOF (otoferlin [Source:HGNC Symbol;Acc:HGNC:8515]) HSP 1 Score: 644.425 bits (1661), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 425/598 (71.07%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVR+YV+RA DLHPAD NGK+DPY+ +RLG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCK+ D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVIIWNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD++F+ F+NPLKS+KYLIC ++KW +IK ++ L +L LF+Y+ PGY+ K++LGA Sbjct: 638 IDELKVYPKELE--SEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHF-GPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230 HSP 2 Score: 355.525 bits (911), Expect = 1.969e-100 Identity = 187/501 (37.33%), Postives = 288/501 (57.49%), Query Frame = 3 Query: 2331 SPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 S +T LD+ER+K LE M +A+ + + + +L+ C+ ++KL L PQ+ +PDIFIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q ++++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 38 SSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP-------------------------------------PINGPVDVDRGP--------IMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 485
BLAST of Otoferlin vs. Ensembl Human
Match: OTOF (otoferlin [Source:HGNC Symbol;Acc:HGNC:8515]) HSP 1 Score: 635.565 bits (1638), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 424/598 (70.90%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLM--LYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVR+YV+RA DLHPAD NGK+DPY+ +RLG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCK+ D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVIIWNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD+SF+ F+NPLKS +Y + + ++W L+K L++ LL LL LF+Y+ PGYL K++LGA Sbjct: 715 IDELKVYPKELE--SEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHF-GPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1307 HSP 2 Score: 355.91 bits (912), Expect = 3.492e-100 Identity = 187/501 (37.33%), Postives = 288/501 (57.49%), Query Frame = 3 Query: 2331 SPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 S +T LD+ER+K LE M +A+ + + + +L+ C+ ++KL L PQ+ +PDIFIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q ++++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 95 SSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP-------------------------------------PINGPVDVDRGP--------IMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 542
BLAST of Otoferlin vs. Ensembl Celegans
Match: fer-1 (Sperm vesicle fusion protein fer-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17388]) HSP 1 Score: 155.992 bits (393), Expect = 1.753e-37 Identity = 107/352 (30.40%), Postives = 159/352 (45.17%), Query Frame = 3 Query: 5625 LVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNK--------------------------------------------------DGSVSTISIFKNKRYRGWWPFTGE-------------NED---DPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 LVPEH+E+RPLF+ + Q+G L M++D+FP E GA P P +IAPR+PI+Y+LR+ + + I E SD++VK ++ G+ TD H+R L G G FNWRF+ NFDY E K+V K+ F E+ P L +++WD + D LG +EL L G SP G++ K +G T++IF+++ GWWP E N+D DPK + G ++ + LL+K+E + P G R+EPN P +PD ++ N + C K+ W Sbjct: 1524 LVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSF--AEPVSDLYVKAFINGM-TKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPI-LVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKW--IMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRK--SWANSWLVSRIKPCIKYFW 1867 HSP 2 Score: 110.538 bits (275), Expect = 1.101e-23 Identity = 72/245 (29.39%), Postives = 116/245 (47.35%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNK------VTVAEVAFY 5519 +E +++ PLE++ + F+ F+ TFP K + D ++ + G K L I K+ + + + P + LVR+Y+I AN L G+ D Y+ L G + +N K+NY + +PIFG+ ++ V P E +L I VM + D IG T IDLENR +K +A GL F G +WRD P +L C + PK E+ + +T+ ++ F+ Sbjct: 1178 MEYVRIFRRPLEQMNGYNNFSDFLDTFPFVKSMKGDFDDPEEKEKAGELKCRLLISKLKKGKPPAA-------INTVVDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIESRQTERGEEKGITIEKITFW 1415 HSP 3 Score: 85.8853 bits (211), Expect = 3.955e-16 Identity = 119/575 (20.70%), Postives = 222/575 (38.61%), Query Frame = 3 Query: 990 IGEFRMDVRTVYNAPDHMFLHKWAML-------VDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANL-LLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKK-------NTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMR--VKAKTMYQDCTKANLAIRLKECRAIIKKLN-ELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKP 2660 +GEF + V ++PD + KW L +P DI G++KV L++ E D+ E I + L+ T+K ++++ E L R +M K +V V H T ++ N + ++ +EI +PT+ + I S++D CI + + I G+TG+LPTFGP+++N++ R + R ++ +G + GRL IAI V E +S ++ C E + + ++I+ + P+ +S+G+ G S +NE C+S+T P P+ + +YF + + +P + + E + R + N+L K+ N + + + AL+ + I+S+ + + VS LD+ + K + K+R + + D + + +L I+ + EL + Q +P + I ++ K + FA+IP EI S + G + +Q P Sbjct: 48 VGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDES-------PPTLIDDDGKEQIWSGAHLIDYTLK-----------IRVFSVEQLIR---------QMINERKIKKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPGETGYLPTFGPAFLNVFDCERVTRFSIFSR---KMRGSQQDGSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFA--SDPVCIMMSIGSFG----STSNEFRS-----------------CNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQIDSASKYLGRINPVSSNA-LDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAEDVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQWP 568 HSP 4 Score: 75.8702 bits (185), Expect = 3.726e-13 Identity = 36/110 (32.73%), Postives = 62/110 (56.36%), Query Frame = 3 Query: 3474 VPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPL-KYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 +P E RP + V+FL WGVR +++ +L++V +P + + G + + PNF P+ + +++LP L PPL+I D R F R L+G+ ++S++ KYV Sbjct: 999 IPTEFRPQFDKFHVQFLCWGVRNLKKHKLLAVRRPFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVILPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYV 1108
BLAST of Otoferlin vs. Ensembl Celegans
Match: fer-1 (Sperm vesicle fusion protein fer-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17388]) HSP 1 Score: 155.992 bits (393), Expect = 1.753e-37 Identity = 107/352 (30.40%), Postives = 159/352 (45.17%), Query Frame = 3 Query: 5625 LVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNK--------------------------------------------------DGSVSTISIFKNKRYRGWWPFTGE-------------NED---DPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 LVPEH+E+RPLF+ + Q+G L M++D+FP E GA P P +IAPR+PI+Y+LR+ + + I E SD++VK ++ G+ TD H+R L G G FNWRF+ NFDY E K+V K+ F E+ P L +++WD + D LG +EL L G SP G++ K +G T++IF+++ GWWP E N+D DPK + G ++ + LL+K+E + P G R+EPN P +PD ++ N + C K+ W Sbjct: 1524 LVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSF--AEPVSDLYVKAFINGM-TKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPI-LVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKW--IMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRK--SWANSWLVSRIKPCIKYFW 1867 HSP 2 Score: 110.538 bits (275), Expect = 1.101e-23 Identity = 72/245 (29.39%), Postives = 116/245 (47.35%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNK------VTVAEVAFY 5519 +E +++ PLE++ + F+ F+ TFP K + D ++ + G K L I K+ + + + P + LVR+Y+I AN L G+ D Y+ L G + +N K+NY + +PIFG+ ++ V P E +L I VM + D IG T IDLENR +K +A GL F G +WRD P +L C + PK E+ + +T+ ++ F+ Sbjct: 1178 MEYVRIFRRPLEQMNGYNNFSDFLDTFPFVKSMKGDFDDPEEKEKAGELKCRLLISKLKKGKPPAA-------INTVVDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIESRQTERGEEKGITIEKITFW 1415 HSP 3 Score: 85.8853 bits (211), Expect = 3.955e-16 Identity = 119/575 (20.70%), Postives = 222/575 (38.61%), Query Frame = 3 Query: 990 IGEFRMDVRTVYNAPDHMFLHKWAML-------VDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANL-LLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKK-------NTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMR--VKAKTMYQDCTKANLAIRLKECRAIIKKLN-ELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKP 2660 +GEF + V ++PD + KW L +P DI G++KV L++ E D+ E I + L+ T+K ++++ E L R +M K +V V H T ++ N + ++ +EI +PT+ + I S++D CI + + I G+TG+LPTFGP+++N++ R + R ++ +G + GRL IAI V E +S ++ C E + + ++I+ + P+ +S+G+ G S +NE C+S+T P P+ + +YF + + +P + + E + R + N+L K+ N + + + AL+ + I+S+ + + VS LD+ + K + K+R + + D + + +L I+ + EL + Q +P + I ++ K + FA+IP EI S + G + +Q P Sbjct: 48 VGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDES-------PPTLIDDDGKEQIWSGAHLIDYTLK-----------IRVFSVEQLIR---------QMINERKIKKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPGETGYLPTFGPAFLNVFDCERVTRFSIFSR---KMRGSQQDGSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFA--SDPVCIMMSIGSFG----STSNEFRS-----------------CNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQIDSASKYLGRINPVSSNA-LDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAEDVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQWP 568 HSP 4 Score: 75.8702 bits (185), Expect = 3.726e-13 Identity = 36/110 (32.73%), Postives = 62/110 (56.36%), Query Frame = 3 Query: 3474 VPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPL-KYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 +P E RP + V+FL WGVR +++ +L++V +P + + G + + PNF P+ + +++LP L PPL+I D R F R L+G+ ++S++ KYV Sbjct: 999 IPTEFRPQFDKFHVQFLCWGVRNLKKHKLLAVRRPFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVILPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYV 1108
BLAST of Otoferlin vs. Ensembl Celegans
Match: fer-1 (Sperm vesicle fusion protein fer-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17388]) HSP 1 Score: 155.992 bits (393), Expect = 2.152e-37 Identity = 107/352 (30.40%), Postives = 159/352 (45.17%), Query Frame = 3 Query: 5625 LVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNK--------------------------------------------------DGSVSTISIFKNKRYRGWWPFTGE-------------NED---DPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 LVPEH+E+RPLF+ + Q+G L M++D+FP E GA P P +IAPR+PI+Y+LR+ + + I E SD++VK ++ G+ TD H+R L G G FNWRF+ NFDY E K+V K+ F E+ P L +++WD + D LG +EL L G SP G++ K +G T++IF+++ GWWP E N+D DPK + G ++ + LL+K+E + P G R+EPN P +PD ++ N + C K+ W Sbjct: 1651 LVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSF--AEPVSDLYVKAFINGM-TKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPI-LVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKW--IMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRK--SWANSWLVSRIKPCIKYFW 1994 HSP 2 Score: 110.923 bits (276), Expect = 9.999e-24 Identity = 72/245 (29.39%), Postives = 116/245 (47.35%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNK------VTVAEVAFY 5519 +E +++ PLE++ + F+ F+ TFP K + D ++ + G K L I K+ + + + P + LVR+Y+I AN L G+ D Y+ L G + +N K+NY + +PIFG+ ++ V P E +L I VM + D IG T IDLENR +K +A GL F G +WRD P +L C + PK E+ + +T+ ++ F+ Sbjct: 1305 MEYVRIFRRPLEQMNGYNNFSDFLDTFPFVKSMKGDFDDPEEKEKAGELKCRLLISKLKKGKPPAA-------INTVVDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIESRQTERGEEKGITIEKITFW 1542 HSP 3 Score: 85.8853 bits (211), Expect = 4.187e-16 Identity = 119/575 (20.70%), Postives = 222/575 (38.61%), Query Frame = 3 Query: 990 IGEFRMDVRTVYNAPDHMFLHKWAML-------VDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANL-LLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKK-------NTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMR--VKAKTMYQDCTKANLAIRLKECRAIIKKLN-ELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKP 2660 +GEF + V ++PD + KW L +P DI G++KV L++ E D+ E I + L+ T+K ++++ E L R +M K +V V H T ++ N + ++ +EI +PT+ + I S++D CI + + I G+TG+LPTFGP+++N++ R + R ++ +G + GRL IAI V E +S ++ C E + + ++I+ + P+ +S+G+ G S +NE C+S+T P P+ + +YF + + +P + + E + R + N+L K+ N + + + AL+ + I+S+ + + VS LD+ + K + K+R + + D + + +L I+ + EL + Q +P + I ++ K + FA+IP EI S + G + +Q P Sbjct: 175 VGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDES-------PPTLIDDDGKEQIWSGAHLIDYTLK-----------IRVFSVEQLIR---------QMINERKIKKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPGETGYLPTFGPAFLNVFDCERVTRFSIFSR---KMRGSQQDGSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFA--SDPVCIMMSIGSFG----STSNEFRS-----------------CNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQIDSASKYLGRINPVSSNA-LDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAEDVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQWP 695 HSP 4 Score: 76.2554 bits (186), Expect = 3.216e-13 Identity = 36/110 (32.73%), Postives = 62/110 (56.36%), Query Frame = 3 Query: 3474 VPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPL-KYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 +P E RP + V+FL WGVR +++ +L++V +P + + G + + PNF P+ + +++LP L PPL+I D R F R L+G+ ++S++ KYV Sbjct: 1126 IPTEFRPQFDKFHVQFLCWGVRNLKKHKLLAVRRPFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVILPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYV 1235
BLAST of Otoferlin vs. Ensembl Celegans
Match: ferl-1 (FER-1 Like [Source:UniProtKB/TrEMBL;Acc:O01596]) HSP 1 Score: 78.5666 bits (192), Expect = 5.189e-14 Identity = 115/568 (20.25%), Postives = 211/568 (37.15%), Query Frame = 3 Query: 990 IGEFRMDVRTVYNAPDHMFLHKWAML-------VDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWN-EEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMR--VKAKTMYQDCTKANLAIRLKECRAIIKKLN-ELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKP 2660 +GEF + V +PD + KW L +P DI G++KV L++ E P I G K Q+ ++++ E L R KM K +V V H +T ++ + N I+F S++D CI + + I G G+LPTFGP+++N++ R + R ++ +G + GRL IAI V E YS ++ C + + + + ID + P+ +S+G+ G S +NE+++ C+S+T P P+ ++ E ++ +P + + E R + N+L K+ N + + + + +L+ + IES+ ++ + HV+ LD+ + K + K+R + + D + + +L I+ + EL + Q +P + I ++ K + FA+IP EI S + G + +Q P Sbjct: 175 VGEFSCYLSEVIRSPDRSLIAKWVALGFPGMSDEEPDDIAYENCGFLKVTLSVYRIDESP-------------------------PTLIDDGGKEQIWS-GIRVFSVEQLIR---------KMINERKIKKKQRFYVMVQCGAHKTKTTMESAFLDEDANIASIIF-------------SLFDKKGRGKTCIGKATLPMKMIYEPGVAGYLPTFGPAFLNVFDCERVSRFSIFSR---KMRGSQLDGSRFVGRLFIAIDCVEYMEKANAQIMHLDYSQIMEAESICKNLKWYNCFCSMSLVNKIDPQFA--SDPVCIMMSIGSFG----STSNEDKK-----------------CNSSTVPTYPERDEHECCSFAWGNLRPVAEVNAPWEVIDRRIEMSNVLMKMTNMLDSMISEIRHISSGAVDQIASVGIESLECLEQQIESASKFLRRINHVNSNA-LDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLQIRSMTLELAEDVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQWP 667
BLAST of Otoferlin vs. Ensembl Celegans
Match: snt-5 (SyNapTotagmin [Source:UniProtKB/TrEMBL;Acc:O16700]) HSP 1 Score: 58.151 bits (139), Expect = 4.767e-8 Identity = 32/84 (38.10%), Postives = 48/84 (57.14%), Query Frame = 3 Query: 5070 IYVIRANDLHPADPNGKSDPYLLLRL---GNKVINEKENYIPKQLNPIFGKCFELDVKFPQ--ESNLLIQVMDWDLVSGDDIIG 5306 I V +A +L P D G SDPY+ + G + ++K + LNP+F + D+ Q E+N+LIQVMDWD + DD++G Sbjct: 286 INVSKAYNLRPMDITGASDPYVKIEQTFNGKRFKSKKSSTKRANLNPVFHETLVFDIPSSQIAETNILIQVMDWDRIGKDDLLG 369
BLAST of Otoferlin vs. Ensembl Fly
Match: mfr (gene:FBgn0266757 transcript:FBtr0273291) HSP 1 Score: 298.516 bits (763), Expect = 1.772e-86 Identity = 168/476 (35.29%), Postives = 264/476 (55.46%), Query Frame = 3 Query: 5046 DPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDV--NGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 6464 + V++LVR+YV++ + P D G SD Y+ L LG K +++ ++ P NP+FG+ FE++ P + L + V D D + D++IG+T IDLE+R+ ++H+A GL + GYN W D++LP+ +L LC++ G P Y N + V + F + I +D ++ E L+L V+KN K+P+ G LVPEH+ETR L + P ++QG L++WI++F + P PIDI P P +E+RV++ N + D + G+ SD++V GW + Q TD+HYRS +G+ FNWR +F Y ED +V I+ ++E E K P +YLQVWD D++T D++L LEL LS + + Q C + + I++FK K GW+P + NGK+ ++ + E P G G++ P AL P RPDSSF +P KS ++++ Sbjct: 151 ETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIK-DEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYG--NVIEVDGMLFGDETLISKD----EELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPS-PIDITPVPPADFEVRVVVKNLVGIQAGDKNIF-GKLMSDVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMV--IRRKAGLLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR----KRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 610
BLAST of Otoferlin vs. Ensembl Fly
Match: mfr (gene:FBgn0266757 transcript:FBtr0273287) HSP 1 Score: 299.286 bits (765), Expect = 5.938e-82 Identity = 168/476 (35.29%), Postives = 264/476 (55.46%), Query Frame = 3 Query: 5046 DPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDV--NGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 6464 + V++LVR+YV++ + P D G SD Y+ L LG K +++ ++ P NP+FG+ FE++ P + L + V D D + D++IG+T IDLE+R+ ++H+A GL + GYN W D++LP+ +L LC++ G P Y N + V + F + I +D ++ E L+L V+KN K+P+ G LVPEH+ETR L + P ++QG L++WI++F + P PIDI P P +E+RV++ N + D + G+ SD++V GW + Q TD+HYRS +G+ FNWR +F Y ED +V I+ ++E E K P +YLQVWD D++T D++L LEL LS + + Q C + + I++FK K GW+P + NGK+ ++ + E P G G++ P AL P RPDSSF +P KS ++++ Sbjct: 854 ETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIK-DEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYG--NVIEVDGMLFGDETLISKD----EELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPS-PIDITPVPPADFEVRVVVKNLVGIQAGDKNIF-GKLMSDVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMV--IRRKAGLLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR----KRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 1313
BLAST of Otoferlin vs. Ensembl Fly
Match: mfr (gene:FBgn0266757 transcript:FBtr0273290) HSP 1 Score: 298.901 bits (764), Expect = 1.224e-81 Identity = 168/476 (35.29%), Postives = 264/476 (55.46%), Query Frame = 3 Query: 5046 DPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDV--NGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 6464 + V++LVR+YV++ + P D G SD Y+ L LG K +++ ++ P NP+FG+ FE++ P + L + V D D + D++IG+T IDLE+R+ ++H+A GL + GYN W D++LP+ +L LC++ G P Y N + V + F + I +D ++ E L+L V+KN K+P+ G LVPEH+ETR L + P ++QG L++WI++F + P PIDI P P +E+RV++ N + D + G+ SD++V GW + Q TD+HYRS +G+ FNWR +F Y ED +V + K ++E E K P +YLQVWD D++T D++L LEL LS + + Q C + + I++FK K GW+P + NGK+ ++ + E P G G++ P AL P RPDSSF +P KS ++++ Sbjct: 942 ETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIK-DEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYG--NVIEVDGMLFGDETLISKD----EELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPS-PIDITPVPPADFEVRVVVKNLVGIQAGDKNIF-GKLMSDVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAG--LLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR----KRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 1401 HSP 2 Score: 59.3066 bits (142), Expect = 4.988e-8 Identity = 33/107 (30.84%), Postives = 56/107 (52.34%), Query Frame = 3 Query: 1371 PFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYG--TPRNYTYDQMMRPKEEL 1685 PF++ F G+T V KNT TP WN EI F M+P++ R + ++ + + +C+A + L +I G P+ GP++++LY P Y +M + E+ Sbjct: 3 PFLKYRFHPFKGKTPVVKNTTTPVWNYEINFAWMYPSVAQRFLILIFAHEHLQWKCVAEFELCLEEIAFNGT----PSLGPTYLHLYDPVNPMIYVGRLLMELRSEM 105
BLAST of Otoferlin vs. Ensembl Fly
Match: mfr (gene:FBgn0266757 transcript:FBtr0273289) HSP 1 Score: 298.516 bits (763), Expect = 3.560e-81 Identity = 168/476 (35.29%), Postives = 264/476 (55.46%), Query Frame = 3 Query: 5046 DPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDV--NGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 6464 + V++LVR+YV++ + P D G SD Y+ L LG K +++ ++ P NP+FG+ FE++ P + L + V D D + D++IG+T IDLE+R+ ++H+A GL + GYN W D++LP+ +L LC++ G P Y N + V + F + I +D ++ E L+L V+KN K+P+ G LVPEH+ETR L + P ++QG L++WI++F + P PIDI P P +E+RV++ N + D + G+ SD++V GW + Q TD+HYRS +G+ FNWR +F Y ED +V I+ ++E E K P +YLQVWD D++T D++L LEL LS + + Q C + + I++FK K GW+P + NGK+ ++ + E P G G++ P AL P RPDSSF +P KS ++++ Sbjct: 1150 ETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIK-DEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYG--NVIEVDGMLFGDETLISKD----EELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPS-PIDITPVPPADFEVRVVVKNLVGIQAGDKNIF-GKLMSDVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMV--IRRKAGLLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR----KRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 1609 HSP 2 Score: 108.997 bits (271), Expect = 4.446e-23 Identity = 88/333 (26.43%), Postives = 151/333 (45.35%), Query Frame = 3 Query: 732 EDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDP---KDILSGA---KGYVKVDLTIMGKGEQVXXX-------XXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYG--TPRNYTYDQMMRPKEEL 1685 +++ I ITV +A Q+ + + + + TK+T+ +T +P++N+Y FEFH + EL I +M + ++GE +D+ +V+N +H + KW L P L A GY+++DL I+ + V + ++ K D+D +DIE NLL I + V Y+ + + N +QVSFAG G+T V KNT TP WN EI F M+P++ R + ++ + + +C+A + L +I G P+ GP++++LY P Y +M + E+ Sbjct: 13 QEFLICITVHKAAQVGVTTGELYVRISLDKMTKSTKSFPNTENPFFNEYFVFEFHCTLTELLRLTILFEL--KKHMTYKK---NVVVGELLVDLHSVWNQSNHGYFKKWGRLEAPIGENQTLENAVAPHGYLQLDLAIVSQHSPVSYALGSEEQDTQNLNKWTVDHDFDDIEKNLLTNVNIFAPSN---IRYFVAFYRGYFIKQSNY--------------------MIQVSFAGFNGKTPVVKNTTTPVWNYEINFAWMYPSVAQRFLILIFAHEHLQWKCVAEFELCLEEIAFNGT----PSLGPTYLHLYDPVNPMIYVGRLLMELRSEM 313
BLAST of Otoferlin vs. Ensembl Fly
Match: mfr (gene:FBgn0266757 transcript:FBtr0273285) HSP 1 Score: 280.026 bits (715), Expect = 5.473e-77 Identity = 159/455 (34.95%), Postives = 250/455 (54.95%), Query Frame = 3 Query: 5046 DPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDV--NGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSP 6401 + V++LVR+YV++ + P D G SD Y+ L LG K +++ ++ P NP+FG+ FE++ P + L + V D D + D++IG+T IDLE+R+ ++H+A GL + GYN W D++LP+ +L LC++ G P Y N + V + F + I +D ++ E L+L V+KN K+P+ G LVPEH+ETR L + P ++QG L++WI++F + P PIDI P P +E+RV++ N + D + G+ SD++V GW + Q TD+HYRS +G+ FNWR +F Y ED +V I+ ++E E K P +YLQVWD D++T D++L LEL LS + + Q C + + I++FK K GW+P + NGK+ ++ + E P G G++ P AL P Sbjct: 607 ETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIK-DEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYG--NVIEVDGMLFGDETLISKD----EELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPS-PIDITPVPPADFEVRVVVKNLVGIQAGDKNIF-GKLMSDVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMV--IRRKAGLLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR----KRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPP 1045
BLAST of Otoferlin vs. Ensembl Zebrafish
Match: otofa (otoferlin a [Source:NCBI gene;Acc:557476]) HSP 1 Score: 871.692 bits (2251), Expect = 0.000e+0 Identity = 490/1320 (37.12%), Postives = 747/1320 (56.59%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF---------------ENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQT----------DNESIESGEDDE---------------SFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVYSVPP--ISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEA-------------------------NEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKF----RRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 MALV++LK V L + DRI K+ FR ++V+ +D F + F+WP+G ++D + LE++++ YSK N+LIG+ + LQK++E+ + + LID N++ I+ T+S E+ Y + D + W EF ++ ++ R S HG+ + ++ G G+T D+ +I ED + S A+ A T V + + P+ + D+QIS+TVIEARQL G N++P++ V IGE+ K T ++ STN PYYN+Y F+FH+ +FD++I++ + N+ L G L+G F++DV TVY P+H F HKWAML DP DI +G KGYVK D+ ++GKG+ +K K++ + D++DIE NLLLP+ + + +RQ A VKIY+AE LP+MNT IMA +K A G+++ LVDP+V V FAG G+T V+K++Y P WNE+++FTEMFP LC R++V + D D V + I TH+IDL ++ N+GD GFLPT GP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLLI+I +L + S + + +V+ P IS+ GK E F L G+F EA++ID +IG K PI FE+++G GN++D + + EEE E + G+ +P +T PM P D+ YFHL + EKKPC+Y+ S+ +D + R + NI++K+ ++ + + E+ E+ R++ L+ + + +++S +T LD+ER+K +E M +AKT+ + + +LK +++L L PQ+ +PD+FIW+I + KR+A+ARIP+++ILYS + EE G +V VFL+ PG+ G GP+GWT+Q +L+MYLWLGL + K F GLP G+ N K PP+ ++Y K FQLRAHM+ AR+L +D SGLSD FAR+ + H T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK+EF+GR F KP + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P R A L ++G + D P ++PVP IRP L YR+E LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR IL+G+H ++ + K++ Sbjct: 1 MALVVHLKTVTELRGKGDRIAKVTFRGLSFFSRVLENCEDEARFEQAFRWPIGSQVDGDEMLEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTTISIEIKYQTMDGSVKVWSDGEFLDIPDDLDGTFQFETDSLLSGRSQSSGTSPGRSIHGIPTFRKA----GKGVFSAMKLGKTRTSKDDHKKGDDAAILDAEDLDRKAMRLGGILDPDTISLASVTAVTTNVSNKRSKPDIKMEPSSGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKISVIHSKNL----LRSGTLVGTFKLDVGTVYTQPEHQFHHKWAMLSDPDDITTGCKGYVKCDIAVVGKGDNIKTPHKAS-----EADEDDIEGNLLLPEGVPS--ERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVLVQFAGQKGKTSVQKSSYEPIWNEQVIFTEMFPPLCRRLKVQIRDSDKVNDVAIGTHFIDLRKVSNDGDKGFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISIAVEILDTTSAEIMSSTEVHMEPVSNISESATGKMEEFFLFGSFLEATMIDRKIGDK--PISFEVTIGNYGNQIDGVSKPALAKKKKEGGGESEEEESELIHNSSEEEAE----DDGDLTSVP-----STPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEIIKTEKAYPERRLRGVLEELSTSCSRFVTLANKDQNLSGRTKLDRERLKSCMREMESMGQQAKTIRTQVKRNTVRDKLKLVLNFLQRLRFLADEPQHSIPDVFIWMISNNKRIAYARIPSKDILYSIVDEEMGKDCGKVKAVFLRLPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLIGLPSGFEENKAVKGIGIQAVPPISLVYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEAGELRDDPPIIVIELYDQDTV--------GKAEFIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCAAGDLLAAFELLQIGP--AGRAA-------------------------------LPPIDGPTDSDRGP------------ILPVPLGIRPVLSRYRIEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGSHAVTTLRKFI 1238 HSP 2 Score: 655.596 bits (1690), Expect = 0.000e+0 Identity = 326/599 (54.42%), Postives = 431/599 (71.95%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS---DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 ++ VY LE EF F ++ TF L +G+ DD++ + ++RIVG FKG+L +YK+ E + +++S+P+NDP+ +LVRIY+IRA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + HGYN WRD Q P +LAKLCKE D P Y +V VA F EIE+++G KKQ+ E LAL V+++W ++P GC L+PEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L+K PRGAK+ + C L + K+ + TISIFK KR +GWWPF +NE+D E ++ GK++AE LL+ EE E PVGLGRN+P L PNRPD++FL F++PLK+++YLICN++KW +IK ++ LL ++ LF+Y+ PGYL K++LGA Sbjct: 1399 VDELMVYNKELES--EFGSFEDWLHTFNLYRGKAGDDDDHNVVDEDRIVGRFKGSLCMYKLPLSEEITREAGFDPNMGMFQSIPHNDPINVLVRIYIIRATDLHPADINGKADPYIVIKLGKSDIRDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSVHGYNVWRDPQKPAQILAKLCKEGKLDGPHY-GPGGRVKVANRIFLGPTEIEDESGLKKQTEEHLALTVLRHWEEIPRVGCKLIPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDVPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNKFPRGAKTAKQCSLDMVLKEHELPTISIFKQKRVKGWWPFVAQNEND--EFELTGKVEAELHLLTAEEAEKSPVGLGRNDPEPLEKPNRPDTTFLWFLSPLKAIRYLICNRYKWLIIKIVLALLLLIMVGLFLYSMPGYLVKKLLGA 1992
BLAST of Otoferlin vs. Ensembl Zebrafish
Match: otofa (otoferlin a [Source:NCBI gene;Acc:557476]) HSP 1 Score: 871.307 bits (2250), Expect = 0.000e+0 Identity = 490/1320 (37.12%), Postives = 747/1320 (56.59%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF---------------ENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQT----------DNESIESGEDDE---------------SFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVYSVPP--ISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEA-------------------------NEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKF----RRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 MALV++LK V L + DRI K+ FR ++V+ +D F + F+WP+G ++D + LE++++ YSK N+LIG+ + LQK++E+ + + LID N++ I+ T+S E+ Y + D + W EF ++ ++ R S HG+ + ++ G G+T D+ +I ED + S A+ A T V + + P+ + D+QIS+TVIEARQL G N++P++ V IGE+ K T ++ STN PYYN+Y F+FH+ +FD++I++ + N+ L G L+G F++DV TVY P+H F HKWAML DP DI +G KGYVK D+ ++GKG+ +K K++ + D++DIE NLLLP+ + + +RQ A VKIY+AE LP+MNT IMA +K A G+++ LVDP+V V FAG G+T V+K++Y P WNE+++FTEMFP LC R++V + D D V + I TH+IDL ++ N+GD GFLPT GP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLLI+I +L + S + + +V+ P IS+ GK E F L G+F EA++ID +IG K PI FE+++G GN++D + + EEE E + G+ +P +T PM P D+ YFHL + EKKPC+Y+ S+ +D + R + NI++K+ ++ + + E+ E+ R++ L+ + + +++S +T LD+ER+K +E M +AKT+ + + +LK +++L L PQ+ +PD+FIW+I + KR+A+ARIP+++ILYS + EE G +V VFL+ PG+ G GP+GWT+Q +L+MYLWLGL + K F GLP G+ N K PP+ ++Y K FQLRAHM+ AR+L +D SGLSD FAR+ + H T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK+EF+GR F KP + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P R A L ++G + D P ++PVP IRP L YR+E LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR IL+G+H ++ + K++ Sbjct: 1 MALVVHLKTVTELRGKGDRIAKVTFRGLSFFSRVLENCEDEARFEQAFRWPIGSQVDGDEMLEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTTISIEIKYQTMDGSVKVWSDGEFLDIPDDLDGTFQFETDSLLSGRSQSSGTSPGRSIHGIPTFRKA----GKGVFSAMKLGKTRTSKDDHKKGDDAAILDAEDLDRKAMRLGGILDPDTISLASVTAVTTNVSNKRSKPDIKMEPSSGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKISVIHSKNL----LRSGTLVGTFKLDVGTVYTQPEHQFHHKWAMLSDPDDITTGCKGYVKCDIAVVGKGDNIKTPHKAS-----EADEDDIEGNLLLPEGVPS--ERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVLVQFAGQKGKTSVQKSSYEPIWNEQVIFTEMFPPLCRRLKVQIRDSDKVNDVAIGTHFIDLRKVSNDGDKGFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISIAVEILDTTSAEIMSSTEVHMEPVSNISESATGKMEEFFLFGSFLEATMIDRKIGDK--PISFEVTIGNYGNQIDGVSKPALAKKKKEGGGESEEEESELIHNSSEEEAE----DDGDLTSVP-----STPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEIIKTEKAYPERRLRGVLEELSTSCSRFVTLANKDQNLSGRTKLDRERLKSCMREMESMGQQAKTIRTQVKRNTVRDKLKLVLNFLQRLRFLADEPQHSIPDVFIWMISNNKRIAYARIPSKDILYSIVDEEMGKDCGKVKAVFLRLPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLIGLPSGFEENKAVKGIGIQAVPPISLVYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEAGELRDDPPIIVIELYDQDTV--------GKAEFIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCAAGDLLAAFELLQIGP--AGRAA-------------------------------LPPIDGPTDSDRGP------------ILPVPLGIRPVLSRYRIEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGSHAVTTLRKFI 1238 HSP 2 Score: 645.966 bits (1665), Expect = 0.000e+0 Identity = 325/599 (54.26%), Postives = 428/599 (71.45%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS---DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 ++ VY LE EF F ++ TF L +G+ DD++ + ++RIVG FKG+L +YK+ E + +++S+P+NDP+ +LVRIY+IRA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + HGYN WRD Q P +LAKLCKE D P Y +V VA F EIE+++G KKQ+ E LAL V+++W ++P GC L+PEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L+K PRGAK+ + C L + K+ + TISIFK KR +GWWPF +NE+D E ++ GK++AE LL+ EE E PVGLGRN+P L PNRPD+S + FMNPL+S++Y I + ++W ++KAL + LL L+ LF+Y+ PGYL K++LGA Sbjct: 1399 VDELMVYNKELE--SEFGSFEDWLHTFNLYRGKAGDDDDHNVVDEDRIVGRFKGSLCMYKLPLSEEITREAGFDPNMGMFQSIPHNDPINVLVRIYIIRATDLHPADINGKADPYIVIKLGKSDIRDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSVHGYNVWRDPQKPAQILAKLCKEGKLDGPHY-GPGGRVKVANRIFLGPTEIEDESGLKKQTEEHLALTVLRHWEEIPRVGCKLIPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDVPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNKFPRGAKTAKQCSLDMVLKEHELPTISIFKQKRVKGWWPFVAQNEND--EFELTGKVEAELHLLTAEEAEKSPVGLGRNDPEPLEKPNRPDTSLMWFMNPLRSIRYFIWHNYRWLILKALALLLLLLLVGLFLYSIPGYLVKKLLGA 1992
BLAST of Otoferlin vs. Ensembl Zebrafish
Match: otofb (otoferlin b [Source:ZFIN;Acc:ZDB-GENE-110406-5]) HSP 1 Score: 799.66 bits (2064), Expect = 0.000e+0 Identity = 431/1104 (39.04%), Postives = 649/1104 (58.79%), Query Frame = 3 Query: 654 DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEA----------NEEEEKEV------PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKF----RRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSS 3860 D S A+ A T V + + P+ + D+Q+S+TVIEARQL G N++P++ V IG+ K T ++ STN PYYN+Y F+FH+ +FD+++++ + N+ L G L+G F++DV T+Y PDH F HKWA L DP+DI +G KGYVK D+ ++ KG+ +K K+ +ND++DIE+NLLLP+ + +RQ A +KIY+AE LP+MNT IMA +K A G++K LVDP+VQV FAG G+T ++K++Y P WNE+IVFTE FP LC R+++ + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ R+YT +M ++LN GLGEGV++R RLLI++ +L + S + + +V +P ISD GK E F L G+F EA++ID +IG K PI FE+++G G+ LD+ ++EE E+ V+ G STT PM P D+ YFHL + E+KPC+Y+ S+ +D + R + N+L+K+ ++ + + E+ E+ R++ L+ + + ++ ++ + +T LDKER+KL +E M +AKTM K+N+ R+K + + KL L PQ+ +PDI+IW+I + KR+A+AR+P+++ILYS++ EE G +V T+F + PG+ GP+GWT+Q + ++YLWLGL R K + GLP G+ N K PP+ ++YT K FQLR HM+ AR+L +D +GLSD FARI + H T+V+ ETL P WDQ L+ DH+ Y + +PP++V+E++D+D + GK++F+GR F KP + +E Y PR L +++IYRG AGE+LAAFEL+Q+ P D+ P +G T G ++PVP IRP L YR+E LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G+H ++ + K++ + PA K + N S+ Sbjct: 33 DTISLASVTAVTTNVSNKRSKPDIKIEPSAGRPMDFQVSVTVIEARQLVGLNMDPVVCVEIGDDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKVSVIHSKNL----LRSGTLVGSFKLDVGTIYTQPDHQFFHKWATLCDPEDITAGLKGYVKCDIAVVAKGDTIKTPHKAN-----ENDEDDIESNLLLPEDVPA--ERQWARFYLKIYRAEGLPKMNTSIMANVKKAFIGENKDLVDPYVQVLFAGQKGKTSIQKSSYEPIWNEQIVFTEQFPPLCRRMKLQIRDSDKVNDVAIGTHFIDLRKIANDGDKGFLPTLGPAWVNMYGSTRSYT---LMDEYQDLNEGLGEGVSFRARLLISLAVEILDTSSPEVMSSTEVQVEGIPNISDNATGKVEEFFLFGSFLEATMIDRKIGDK--PINFEVTIGNYGSELDTPTKPKSKKKKGDGDDEESELIHGSSDEEVDDGGDVT----SVSTTPPMKPVITDRNYFHLPYFERKPCIYIYSWWQDQRRRLYNANVLDKMADKLEEGLNDVQEIIKTEKAYPERRLRGVLEELSNSCSTFVSLANNDQNQAGRTKLDKERVKLCMQEVESMGQQAKTMRSQVKKSNVKDRIKLAQNFLHKLRFLSDEPQHSVPDIYIWMISNNKRIAYARVPSKDILYSSVEEECGKDCGKVQTIFFKLPGKKSFGPAGWTVQAKTELYLWLGLNRQRKDYLCGLPNGFEENKAVKGPGVQSSPPISLMYTMKQIFQLRVHMYQARSLFAADSTGLSDPFARIFFSTHSQVTEVLNETLCPTWDQLLVFDHVELYGEAGELRDDPPIIVIEIYDQDTV--------GKADFMGRTFAKPITKMSDEHYGPPRFPPQLEYYQIYRGNCTAGEMLAAFELLQIGPGG--------------------------------------------KADLPPIDGPTDIDRGP-ILPVPIGIRPVLSKYRIEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTTLRKFIYR-------PADKSVNNWSA 1056 HSP 2 Score: 642.114 bits (1655), Expect = 0.000e+0 Identity = 314/600 (52.33%), Postives = 433/600 (72.17%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEE-----SSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLM-LYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 IE FKVY LE E+ F ++ TF L +G+ DD + + ++R++G FKG+L IYKV ++ ++ M +++++P+NDP+ +LVRIYV+RA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FGK F+++ P +S L + + DWDLV DD+IGETKIDLENR+YSKH+A CG+ + HGYN WRD P+ +LAKLCK+ D P+Y +V V + E+E++NG KKQ++E LAL V+ +W +P GC LVPEHMETRPL N +KPGI+QG +EMW+DMFPK++ AP +DI+PR+P +ELRVI+WNT++V+L D + TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRFI+ FDY++AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAK+ + C + + + + ++IFK KR +GWWPF +E+D EL++ GK++AE QLL+ EE E PVG GRNEP L PNRPD++FL FM PLK++++L+CN++KW +IK ++ LLA+L LF+Y+ PGY+ K++LGA Sbjct: 1179 IEEFKVYNRELE--YEYNQFEDWLHTFNLHRGKCSDDADVDQNAADEDRLIGKFKGSLCIYKVSSDDMSRDMGFDSNMGMFQNIPHNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKSEIKDKENYISKQLNPVFGKSFDVEATLPMDSTLTVSIYDWDLVGTDDLIGETKIDLENRFYSKHRATCGISSTYAIHGYNVWRDPLKPSHILAKLCKDGKIDAPQY-GPGGRVKVTNRVYTGPTEVEDENGLKKQTDEHLALAVLNHWEDIPRIGCKLVPEHMETRPLLNPDKPGIEQGRIEMWVDMFPKDMSAPGPALDISPRKPKKFELRVIVWNTDEVVLEDDDIFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLQAEEKIVISKKESMFSWDETEYKIPARLNLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMVTNENEMPMVNIFKQKRIKGWWPFVARDEND--ELEITGKVEAELQLLTGEEAEKSPVGEGRNEPEPLEKPNRPDTAFLWFMMPLKAIRHLVCNQYKWLVIKIVVALLLLAMLGLFLYSMPGYMVKKLLGA 1773
BLAST of Otoferlin vs. Ensembl Zebrafish
Match: fer1l4 (fer-1 like family member 4 [Source:ZFIN;Acc:ZDB-GENE-130530-815]) HSP 1 Score: 635.95 bits (1639), Expect = 0.000e+0 Identity = 420/1329 (31.60%), Postives = 670/1329 (50.41%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADW-RQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIG----EFNYGQTDNESIESGEDDESFAATNARTLGV------PLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIK-------TVLRSESGGL--------------------------------PAG-----------------AKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTG---------NRLDSEANEEEEKE--VPSVNQGNR--PKIPKWCHSTTEPMLPDTN--DQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLN-SIKCVRHVSPK-TLLDKERIKLTK---VCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY--------SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKY 3797 M++ + LK + NL + DR ++++FR F TK+++ ++ F E F+WP K++ + L + ++ SK +N+L+G + ISLQ ++ ++ +E L D+ HS+ + + E+ Y W QD +D L + + + +D +T IG + D + +DD FA L + L H Q+++ VIEA++L G NINP + V +G++ K T Q STN P+YN+ FEF ++ LFD+VI + + +A IG F++D+ TVY PDH F KWA L DPKD SG KGYVK ++++ KG+ + + D DIE NLLLP+ + ++R A+ +KIY+AE LP MN+ M I D K +DP+VQV+FAG G T V NT PEWNE+I F E FP L RI++ + D + + +ATH++DL QI N GF PTFGP+WVNLYG+P+N T + R +LN GL +G+ YRGR+L+++ T + +ES + P+G +V V P+ + G+K+ FLL +F+E ++ID IG K P+ FELS+G G ++ S+ N E+++ + S ++ R P P+ S T P P D+ + + +KPC+++ SY EDH R N L K+ + ++ E+ M +R + +D +E S S R +P+ LDK R+ L K V L K ++ + + T+ + RL + R I K+L L PQ+ LPD+F+W++ +R+A+ARIPA +L+S + EEKG ++ V+++ PG GP G + +L++Y+WLG+ + K LP + S PP ++ + YFQLRAH++ AR +I +D++GLSD FA+++ + T+V+ ETLSP W + L D ++ SKD +PPV+++ ++D N+ G + LGR F +P + EE YK P+L ++EI +G+ AGE+LAA ELI++ S F + L + DV P + + E +++ +P+ +RP L YR+E L+WG+R ++RV L V++P++ +E + S+ I S K+ PNFS+ +K+ D+ LPE + PPL I + R FGR +L+G HV+ N+ ++ Sbjct: 1 MSITVLLKKIFNLPGKYDRKVELSFRGFTHKTKILQCENIAIFNEHFRWPHYGKVERDEVLSISVFNCSKMFSNRLLGKLVISLQHVVSVGQLILREPLTDAQHSLTDMYIELEVKYSPLQGAAGGWDSQDFIREEDSDGLLVIRNTGFTEPSSSDGLRPQQLDRETRMIGRGLLKTEDENGDEDDDNDYDDDYDFADMECANLTLFDGNLKNLLFHSLFSSP---QVNVNVIEAQKLVGVNINPAVYVTVGDEKKHTATQKSTNCPFYNENFMFEFQETQDVLFDKVIEISVVHKKVLAFLM----THIGSFKIDISTVYQQPDHRFYQKWAPLTDPKDTRSGIKGYVKCTVSVVMKGDPMGMASLAPAGSQND----DIEKNLLLPK--RMPSERPWAKFILKIYRAEGLPSMNSGFMG----KIMRDKKVFLDPYVQVTFAGQQGETSVDSNTNAPEWNEQISFIEQFPPLARRIKIQILDDANIGDVAVATHFLDLLQISNPNRNGFNPTFGPAWVNLYGSPQNSTLRDIHR---DLNEGLSDGIFYRGRILLSLSVEVYFSPTAVVTESKAIANVKSTISRLNLKRRSRKSKEKKTGRKEGMQSPSGPAEESEDVGAEVPAAVTVEVEEVHPLPENFTGEKDEFLLFASFFEVTMIDPSIGSK--PVTFELSIGNYGKTAEVVVKSSKSGSQENLAEDRQPLLESDDELERDEPVNPR-DQSITAPRRPQPTEYDRSFSCIPLFREKPCIFVWSYFEDHTFRFHNSNWLSKMADRLEYGID---EVEMLLKRSKIKAKERLVDVVLEFFSSCKQYSSNLERKRNPRQNNLDKCRVGLIKRNIVLLAKQTLRVR---KRVTRNTVKDRLADLRNITKRLRFLAIEPQSTLPDVFLWMLSGGRRVAYARIPAPSVLFSLVEEEKGKDCGKITAVYMKTPG----GPVG-EIFAKLEVYMWLGITKYAKNCVTSLPAEFRPIYEDATSGASIPRNMPPTKLAVEDSRYFQLRAHIYQARGIIAADDNGLSDPFAKVVFSTQCQVTRVMEETLSPTWCELLFYDQVLMEGSKDEYREDPPVVIINIYD--------YNKLGSPQALGRAFARPELKFVEEPYKKPQLQFFEITKGKSKAGEILAALELIEL-----------------------------DYSSFGEPALPV---------DVDPKKPQYMEEECYYI--IPEGVRPVLRKYRIEVLYWGLRGLKRVNLFEVERPQVRMECAGQMIESEEIQSYKLNPNFSDVVKHFDVELPELVYLHPPLTIFVMEQRAFGRLVLVGTHVVQNLVQF 1247 HSP 2 Score: 470.7 bits (1210), Expect = 9.236e-135 Identity = 257/616 (41.72%), Postives = 373/616 (60.55%), Query Frame = 3 Query: 4800 LIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDN--RIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYE----ALVNKV------TVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKV----PNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPF------------------------------TGENEDDPKELD----------VNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFK 6479 LI ++Y LE +F F ++ FP+ KG+ ++E D R +G +KG+ IY + E+ + +P N P+++LVR+YV++A +L P DPNGK+DPY+++++G + ++ KE YIPKQLNP+FG+ FEL V FP E+ L + V D DLV DD+IG+T++DLENR++S+H+A CGL ++ GYNKWRD + PT +L +LC++ G P+Y ++NK+ E + + EED E +E AL V+ W ++ C LVPEH+E R L N+EKPG+ QG + MWIDMFP ++ PP ++I PR P SYELRVIIWNT+DV+L D TGE SSDI+VKGW+KGL + Q TDVH+ SL+GEGNFNWRF+F+FDY+ E +++YK K+S FA++ETE + P L LQVWD D + ++DFLG +EL LS + R K+ + C + ++ KD + SIF++KR +GWWP + ++ P++L + GK++AEF L++ EE E PVG R EP L PNRP +SF F+NP+K+ + I K+K Sbjct: 1354 LIAFLQLYKFELE--NDFSQFMDWLHIFPVYKGKSSLEDEEEDESSRYMGKYKGSFLIYPIAPEDEEA-----DCQITNGIPKNTPIKVLVRVYVVKATNLAPTDPNGKADPYVVVKVGQQQMDSKERYIPKQLNPVFGEVFELTVSFPLETELTLYVFDHDLVGSDDLIGKTRVDLENRFFSRHRAGCGLALHYDKDGYNKWRDAKKPTAILLELCRKNGIPSPEYRESEIKVLNKIFRVPNEAFPEELLKKNKKTEEDYAE---LDEHKALSVLHRWKEMREFCEGACPLVPEHVEVRSLLNAEKPGLPQGYVHMWIDMFPVDVPPPPP-VNIKPRLPESYELRVIIWNTDDVVLDDVNPFTGEPSSDIYVKGWIKGLEDEKQETDVHFNSLTGEGNFNWRFVFHFDYLPTEKEVIYKKKESLFALEETEFRQPAVLVLQVWDYDRIGSNDFLGSIELRLSDMVRAVKTSEQCSV-KMAKDKAGPRFSIFRSKRMKGWWPLIKLKSQEDIEREEREAEQEKKNKKKKKKKSSKRSQMKPEDLQFVDNSGNTFLLMGKVEAEFHLVTPEEAEKNPVGKARKEPEPLDKPNRPKTSFNWFVNPMKTFVFFIWKKYK 1957
BLAST of Otoferlin vs. Ensembl Zebrafish
Match: fer1l4 (fer-1 like family member 4 [Source:ZFIN;Acc:ZDB-GENE-130530-815]) HSP 1 Score: 628.632 bits (1620), Expect = 0.000e+0 Identity = 426/1377 (30.94%), Postives = 680/1377 (49.38%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGM----GSD--KRTLIDPQTGEIGE----------------FNYGQTDNESIESGEDDESFAATNARTLGV-PLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIK-------TVLRSESGGL-------------------------------PAG-----------------AKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTG---------NRLDSEANEEEEKE--VPSVNQGNR--PKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILH---------------------------------------ELHMNERRGTHLRMKNALDTFIENIESSLN-SIKCVRHVSPK-TLLDKERIKLTK---VCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY--------SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKY 3797 M++ + LK + NL + DR ++++FR F TK+++ ++ F E F+WP K++ + L + ++ SK +N+L+G + ISLQ ++ ++ +E L D+ HS+ + + E+ Y W +F + SD ++ I + G SD + +D +T IG D +E + + R L LA+ P K + +Q+++ VIEA++L G NINP + V +G++ K T Q STN P+YN+ FEF ++ LFD+VI + + +A L+ IG F++D+ TVY PDH F KWA L DPKD SG KGYVK ++++ KG+ + + D DIE NLLLP+ + ++R A+ +KIY+AE LP MN+ M I D K +DP+VQV+FAG G T V NT PEWNE+I F E FP L RI++ + D + + +ATH++DL QI N GF PTFGP+WVNLYG+P+N T + R +LN GL +G+ YRGR+L+++ T + +ES + P+G +V V P+ + G+K+ FLL +F+E ++ID IG K P+ FELS+G G ++ S+ N E+++ + S ++ R P P+ S T P P + + F E KPC+++ SY EDH R N L K+ + ++ V + E+ M +R + +D +E S S R +P+ LDK R+ L K V L K ++ + + T+ + RL + R I K+L L PQ+ LPD+F+W++ +R+A+ARIPA +L+S + EEKG ++ V+++ PG GP G + +L++Y+WLG+ + K LP + S PP ++ + YFQLRAH++ AR +I +D++GLSD FA+++ + T+V+ ETLSP W + L D ++ SKD +PPV+++ ++D N+ G + LGR F +P + EE YK P+L ++EI +G+ AGE+LAA ELI++ S F + L + DV P + + E +++ +P+ +RP L YR+E L+WG+R ++RV L V++P++ +E + S+ I S K+ PNFS+ +K+ D+ LPE + PPL I + R FGR +L+G HV+ N+ ++ Sbjct: 1 MSITVLLKKIFNLPGKYDRKVELSFRGFTHKTKILQCENIAIFNEHFRWPHYGKVERDEVLSISVFNCSKMFSNRLLGKLVISLQHVVSVGQLILREPLTDAQHSLTDMYIELEVKYSPLQGAAGGWDSQDF----IREEDSDGSELVIRNTGFTEPSSSDGLRPQQLDRETRMIGRGLLKTEDENGDEDDDNDYDDDYDFADMECANVTFTPILSRCRALAKHELAITP---KVKSFQVNVNVIEAQKLVGVNINPAVYVTVGDEKKHTATQKSTNCPFYNENFMFEFQETQDVLFDKVIEISVVHKKVLAF--LMTH--IGSFKIDISTVYQQPDHRFYQKWAPLTDPKDTRSGIKGYVKCTVSVVMKGDPMGMASLAPAGSQND----DIEKNLLLPK--RMPSERPWAKFILKIYRAEGLPSMNSGFMG----KIMRDKKVFLDPYVQVTFAGQQGETSVDSNTNAPEWNEQISFIEQFPPLARRIKIQILDDANIGDVAVATHFLDLLQISNPNRNGFNPTFGPAWVNLYGSPQNSTLRDIHR---DLNEGLSDGIFYRGRILLSLSVEVYFSPTAVVTESKAIANVKSTISRLNLKRRSRKSKEKKTGRKEVQSPSGPAEESEDVGAEVPAAVTVEVEEVHPLPENFTGEKDEFLLFASFFEVTMIDPSIGSK--PVTFELSIGNYGKTAEVVVKSSKSGSQENLAEDRQPLLESDDELERDEPVNPR-DQSITAPRRPQPTEYDSCIPLFRE-KPCIFVWSYFEDHTFRFHNSNWLSKMADRLASEVRKMSLKTLEELYIILAITSISFLFLEFSKINLCPTFFKEYGIDEVEMLLKRSKIKAKERLVDVVLEFFSSCKQYSSNLERKRNPRQNNLDKCRVGLIKRNIVLLAKQTLRVR---KRVTRNTVKDRLADLRNITKRLRFLAIEPQSTLPDVFLWMLSGGRRVAYARIPAPSVLFSLVEEEKGKDCGKITAVYMKTPG----GPVG-EIFAKLEVYMWLGITKYAKNCVTSLPAEFRPIYEDATSGASIPRNMPPTKLAVEDSRYFQLRAHIYQARGIIAADDNGLSDPFAKVVFSTQCQVTRVMEETLSPTWCELLFYDQVLMEGSKDEYREDPPVVIINIYD--------YNKLGSPQALGRAFARPELKFVEEPYKKPQLQFFEITKGKSKAGEILAALELIEL-----------------------------DYSSFGEPALPV---------DVDPKKPQYMEEECYYI--IPEGVRPVLRKYRIEVLYWGLRGLKRVNLFEVERPQVRMECAGQMIESEEIQSYKLNPNFSDVVKHFDVELPELVYLHPPLTIFVMEQRAFGRLVLVGTHVVQNLVQF 1293 HSP 2 Score: 469.159 bits (1206), Expect = 4.475e-134 Identity = 252/600 (42.00%), Postives = 366/600 (61.00%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGRQDDDEESSDN--RIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYE----ALVNKV------TVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKV----PNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPF------------------------------TGENEDDPKELD----------VNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFK 6479 +F F ++ FP+ KG+ ++E D R +G +KG+ IY + E+ + +P N P+++LVR+YV++A +L P DPNGK+DPY+++++G + ++ KE YIPKQLNP+FG+ FEL V FP E+ L + V D DLV DD+IG+T++DLENR++S+H+A CGL ++ GYNKWRD + PT +L +LC++ G P+Y ++NK+ E + + EED E +E AL V+ W ++ C LVPEH+E R L N+EKPG+ QG + MWIDMFP ++ PP ++I PR P SYELRVIIWNT+DV+L D TGE SSDI+VKGW+KGL + Q TDVH+ SL+GEGNFNWRF+F+FDY+ E +++YK K+S FA++ETE + P L LQVWD D + ++DFLG +EL LS + R K+ + C + ++ KD + SIF++KR +GWWP + ++ P++L + GK++AEF L++ EE E PVG R EP L PNRP +SF F+NP+K+ + I K+K Sbjct: 1443 DFSQFMDWLHIFPVYKGKSSLEDEEEDESSRYMGKYKGSFLIYPIAPEDEEA-----DCQITNGIPKNTPIKVLVRVYVVKATNLAPTDPNGKADPYVVVKVGQQQMDSKERYIPKQLNPVFGEVFELTVSFPLETELTLYVFDHDLVGSDDLIGKTRVDLENRFFSRHRAGCGLALHYDKDGYNKWRDAKKPTAILLELCRKNGIPSPEYRESEIKVLNKIFRVPNEAFPEELLKKNKKTEEDYAE---LDEHKALSVLHRWKEMREFCEGACPLVPEHVEVRSLLNAEKPGLPQGYVHMWIDMFPVDVPPPPP-VNIKPRLPESYELRVIIWNTDDVVLDDVNPFTGEPSSDIYVKGWIKGLEDEKQETDVHFNSLTGEGNFNWRFVFHFDYLPTEKEVIYKKKESLFALEETEFRQPAVLVLQVWDYDRIGSNDFLGSIELRLSDMVRAVKTSEQCSV-KMAKDKAGPRFSIFRSKRMKGWWPLIKLKSQEDIEREEREAEQEKKNKKKKKKKSSKRSQMKPEDLQFVDNSGNTFLLMGKVEAEFHLVTPEEAEKNPVGKARKEPEPLDKPNRPKTSFNWFVNPMKTFVFFIWKKYK 2032
BLAST of Otoferlin vs. Ensembl Xenopus
Match: ube2v2 (ubiquitin conjugating enzyme E2 V2 [Source:Xenbase;Acc:XB-GENE-1015103]) HSP 1 Score: 794.653 bits (2051), Expect = 0.000e+0 Identity = 461/1255 (36.73%), Postives = 705/1255 (56.18%), Query Frame = 3 Query: 243 PMGRKLDPIDTLELRLYQYSKYL--NNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDI--SIDSHGMGSDKRTLIDPQTGE--IGEFNYGQTDNESIESGEDDE-------------------------SFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLL-PGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLD-------------SEANEEEEKEVPSVNQGNRPKIPKWCHSTTEP-MLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR-------PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 P ++ P + L R Y +L +LIG+ + LQ+++E+ ++ + LID N+S IR +VS EL Y + D + W EF + + S A + H S++R + + G+ G+T ES + DE S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G++ K T ++ STN PYYN+ +S V R R + + + LL G L+G F++DV TVY P+H F HKWA+L DP DI +G KGY+K D+ ++GKG+ +K K+ + D++DIE NLLLP + +RQ A VKIY+AE LPRMNT IMA +K A+ G++K LVDP+VQV+FAG G+T V+K++Y P WNE+I+FTEMFP LC R++V + D D V + I TH+IDL +I NEGD GFLPTFGP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLL+++ +L + + L + +V P+++ GK E F L GAF E+++ID +IG K PI FE+++G GN++D + EEE + + + + + + ++ P M P D+ YFHL F +KKPC Y+ S+ +D + R + NI++K+ ++ + +HE+ E+ R++ L+ + + ++ + +T LD+ER+K LE M +AKTM K + +LK + ++KL L PQ+ +PDIFIW++ + KR+A+ARIP+++ILYS + EE G +V VFL+ PG+ G GP+GWT+Q ++++Y+WLGL + + F GLP G+ K + PP+ + YT+K FQLRAHM+ AR+L +D SGLSD FAR+ N T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK++F+GR F KP V + +E Y PR L +++IYRG AG+LL AFEL+Q+ P + +S+ L +EG + + P ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 28 PSDSRVVPGEPLRTRTGAYCVFLRFGARLIGTFRMVLQQVVEEAQLEVTDTLIDDNNSAIRTSVSIELRYQTMDGSVGAWNDGEFMDGTNLQSESMATPLWPVPTPHRTLSNRRLPLICRVGKGVFSAMKLGKTRPPKDESRKQDEPAVLETEDLDRKAIRLAGGLDPDTISLASVTAVTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDEKKYTSMKESTNCPYYNE-------VSATVPTSPVPRDRAVKVSVIHSKNLLRSGTLVGSFKLDVGTVYTQPEHQFYHKWALLSDPDDITAGLKGYLKCDIAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPDGVPA--ERQWARFYVKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPMWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANEGDKGFLPTFGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLLSLAVEILDTTNPELTSSTEVQIEGAQPVAETCTGKMEEFFLFGAFLESTMIDRKIGDK--PINFEVTIGNYGNQIDGISKPSMRKRKEGGDGVEEETELLQNSSDDEADEDGEMLSISSSPAMKPLITDRNYFHLPFFDKKPCTYIKSWWQDQRRRLYNANIMDKIADKLEEGLNDVHEMIKTEKPYPERRLRGVLEELSSSCFRFVTLANKDQNQNGQTKLDRERLKSCMRELENMGTQAKTMRSQVKKNTVKDKLKLVQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRIAYARIPSKDILYSIVDEETGKDCGKVKCVFLKLPGKRGFGPAGWTVQAKMEVYMWLGLSKQRRDFLCGLPCGFEE--IKAVKGPGLQSFPPISLSYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFNTQSQCTEVLNETLCPTWDQLLVFDNIELYGEAHEMRDDPPIIVIEIYDQDTV--------GKADFMGRTFAKPVVKMSDERYCPPRFPPQLEYYQIYRGNSTAGDLLGAFELLQIGP------------------------AGKSD---------LPQIEGPTDIERGP------------ILPVPLGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1208 HSP 2 Score: 640.188 bits (1650), Expect = 0.000e+0 Identity = 317/583 (54.37%), Postives = 420/583 (72.04%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGR--QDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 E++ F ++ TF L +G+ DDD S + RIVG FKG++ +YKV E + + +++ +PNNDP+ +LVR+YV+RA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + + HGYN WRD PT +L+KLCKE D P Y +V V F EI+++NG+KKQ++E LAL V+++W +P GC LVPEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAK+ + C + D + +SIFK KR +GWWPF NE+D E+++ GK++AE LLS EE E P GLGRNEP+ L PNRPD+SF+ F+NPLKS++Y I + ++W ++K LI+ LL ++ LF+Y+ PGYL K++LGA Sbjct: 1341 EYDNFEDWLHTFNLLRGKIGDDDDTVSEEERIVGRFKGSMCVYKVPLPEDVTKEAGYDPNFGMFQGIPNNDPMNVLVRVYVVRATDLHPADINGKADPYVVIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGISKTYAIHGYNLWRDPVKPTQILSKLCKEGKIDGPHY-GPGGRVKVTNRVFTGPTEIDDENGQKKQTDEHLALSVLQHWEDIPRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDMPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFLFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMAEPDVDLPMVSIFKQKRVKGWWPFVARNEND--EMELTGKVEAELHLLSAEEAEKTPAGLGRNEPDPLEKPNRPDTSFIWFLNPLKSIRYFIWHTYRWLILKILILILLLLMVGLFLYSLPGYLVKKILGA 1920
BLAST of Otoferlin vs. Ensembl Xenopus
Match: ube2v2 (ubiquitin conjugating enzyme E2 V2 [Source:Xenbase;Acc:XB-GENE-1015103]) HSP 1 Score: 719.539 bits (1856), Expect = 0.000e+0 Identity = 415/1069 (38.82%), Postives = 604/1069 (56.50%), Query Frame = 3 Query: 741 QISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDG----------TC-GKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS----------EANEEEEKEVPSVNQGNRPKIPK----WCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSN-----AVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCL---EKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR-------PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 Q+SITVIEARQL G N++P++ V +G++ K T ++ STN PYYN+ +S VI + L L G L+G F++DV TVY P+H F HKWA+L DP DI +G KGY+K D+ ++GKG+ +K K+ + D++DIE NLLLP + +RQ A VKIY+AE LPRMNT IMA +K A+ G++K LVDP+VQV+FAG G+T V+K++Y P WNE+I+FTEMFP LC R++V + D D V + I TH+IDL +I NEGD GFLPTFGP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLL+++ +L + + L + +V P+++ TC GK E F L GAF E+++ID +IG K PI FE+++G GN++D E + E+E + + + + S++ M P D+ YFHL F +KKPC Y+ S+ +D + R + NI++K+ ++ N E+LHE A + F+ L H C E M +AKTM K + +LK + ++KL L PQ+ +PDIFIW++ + KR+A+ARIP+++ILYS + EE G +V VFL+ PG+ G GP+GWT+Q ++++Y+WLGL + + F GLP G+ K + PP+ + YT+K FQLRAHM+ AR+L +D SGLSD FAR+ N T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK++F+GR F KP V + +E Y PR L +++IYRG AG+LL AFEL+QV P G D+ EG T G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 39 QVSITVIEARQLVGLNMDPVVCVEVGDEKKYTSMKESTNCPYYNE-------VSATVPTSPVIHSKNL---------LRSGTLVGSFKLDVGTVYTQPEHQFYHKWALLSDPDDITAGLKGYLKCDIAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPDGVPA--ERQWARFYVKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPMWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANEGDKGFLPTFGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLLSLAVEILDTTNPELTSSTEVQIEGAQPVAEVRTTLSYHLHLTCTGKMEEFFLFGAFLESTMIDRKIGDK--PINFEVTIGNYGNQIDGISKPSMRKRKEGGDGVEEETELLQNSSDDEADEDGEMLSISSSPAMKPLITDRNYFHLPFFDKKPCTYIKSWWQDQRRRLYNANIMDKIADKLVNETGQGEAEVLHE--------------GAGNVFVLEGLGRLTGDGLTNH----------------DCFAQQENMGTQAKTMRSQVKKNTVKDKLKLVQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRIAYARIPSKDILYSIVDEETGKDCGKVKCVFLKLPGKRGFGPAGWTVQAKMEVYMWLGLSKQRRDFLCGLPCGFEE--IKAVKGPGLQSFPPISLSYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFNTQSQCTEVLNETLCPTWDQLLVFDNIELYGEAHEMRDDPPIIVIEIYDQDTV--------GKADFMGRTFAKPVVKMSDERYCPPRFPPQLEYYQIYRGNSTAGDLLGAFELLQVI---------------------GPAG----------------------KSDLPQIEGPTDIERGP-ILPVPLGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 995 HSP 2 Score: 599.356 bits (1544), Expect = 0.000e+0 Identity = 298/581 (51.29%), Postives = 401/581 (69.02%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGR--QDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 E++ F ++ TF L +G+ DDD S + RIVG FKG++ +YKV E + + +++ +PNNDP+ +LVR+YV+RA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + + HGYN WRD PT +L+KLCKE D P Y +V V F G+KKQ++E LAL V+++W +P GC LVPEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAK+ + C + D + +SIFK KR +GWWPF NE+D E+++ GK++AE LLS EE E P GLGRNEP+ L PNRP+ S ++PL+ + L+ +++W ++ + A+L + L +Y PG +++R++ Sbjct: 1018 EYDNFEDWLHTFNLLRGKIGDDDDTVSEEERIVGRFKGSMCVYKVPLPEDVTKEAGYDPNFGMFQGIPNNDPMNVLVRVYVVRATDLHPADINGKADPYVVIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGISKTYAIHGYNLWRDPVKPTQILSKLCKEGKIDGPHY-GPGGRVKVTNRVF---------TGQKKQTDEHLALSVLQHWEDIPRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDMPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFLFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMAEPDVDLPMVSIFKQKRVKGWWPFVARNEND--EMELTGKVEAELHLLSAEEAEKTPAGLGRNEPDPLEKPNRPNPSLAWMLSPLRVVCVLLWRQYRWHVLGIIGSCAVLMFVALVLYTLPGAISERLI 1586
BLAST of Otoferlin vs. Ensembl Xenopus
Match: ube2v2 (ubiquitin conjugating enzyme E2 V2 [Source:Xenbase;Acc:XB-GENE-1015103]) HSP 1 Score: 709.523 bits (1830), Expect = 0.000e+0 Identity = 406/1055 (38.48%), Postives = 595/1055 (56.40%), Query Frame = 3 Query: 759 IEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS----------EANEEEEKEVPSVNQGNRPKIPK----WCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAV--------EILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCL---EKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR-------PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 +ARQL G N++P++ V +G++ K T ++ STN PYYN+ +S VI + L L G L+G F++DV TVY P+H F HKWA+L DP DI +G KGY+K D+ ++GKG+ +K K+ + D++DIE NLLLP + +RQ A VKIY+AE LPRMNT IMA +K A+ G++K LVDP+VQV+FAG G+T V+K++Y P WNE+I+FTEMFP LC R++V + D D V + I TH+IDL +I NEGD GFLPTFGP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLL+++ +L + + L + +V P+++ GK E F L GAF E+++ID +IG K PI FE+++G GN++D E + E+E + + + + S++ M P D+ YFHL F +KKPC Y+ S+ +D + R + NI++K+ ++ S E E E H + A + F+ L H C E M +AKTM K + +LK + ++KL L PQ+ +PDIFIW++ + KR+A+ARIP+++ILYS + EE G +V VFL+ PG+ G GP+GWT+Q ++++Y+WLGL + + F GLP G+ K + PP+ + YT+K FQLRAHM+ AR+L +D SGLSD FAR+ N T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK++F+GR F KP V + +E Y PR L +++IYRG AG+LL AFEL+QV P G D+ EG T G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 3 FKARQLVGLNMDPVVCVEVGDEKKYTSMKESTNCPYYNE-------VSATVPTSPVIHSKNL---------LRSGTLVGSFKLDVGTVYTQPEHQFYHKWALLSDPDDITAGLKGYLKCDIAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPDGVPA--ERQWARFYVKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPMWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANEGDKGFLPTFGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLLSLAVEILDTTNPELTSSTEVQIEGAQPVAETCTGKMEEFFLFGAFLESTMIDRKIGDK--PINFEVTIGNYGNQIDGISKPSMRKRKEGGDGVEEETELLQNSSDDEADEDGEMLSISSSPAMKPLITDRNYFHLPFFDKKPCTYIKSWWQDQRRRLYNANIMDKIADKLSICYLGQQGPEPEWADETGQGEAEVLH---EGAGNVFVLEGLGRLTGDGLTNH----------------DCFAQQENMGTQAKTMRSQVKKNTVKDKLKLVQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRIAYARIPSKDILYSIVDEETGKDCGKVKCVFLKLPGKRGFGPAGWTVQAKMEVYMWLGLSKQRRDFLCGLPCGFEE--IKAVKGPGLQSFPPISLSYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFNTQSQCTEVLNETLCPTWDQLLVFDNIELYGEAHEMRDDPPIIVIEIYDQDTV--------GKADFMGRTFAKPVVKMSDERYCPPRFPPQLEYYQIYRGNSTAGDLLGAFELLQVI---------------------GPAG----------------------KSDLPQIEGPTDIERGP-ILPVPLGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 956 HSP 2 Score: 593.193 bits (1528), Expect = 5.931e-179 Identity = 295/581 (50.77%), Postives = 397/581 (68.33%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGR--QDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 E++ F ++ TF L +G+ DDD S + RIVG FKG++ +YKV E + + +++ +PNNDP+ +LVR+YV+RA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + + HGYN WRD PT +L+KLCKE D P Y G+KKQ++E LAL V+++W +P GC LVPEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAK+ + C + D + +SIFK KR +GWWPF NE+D E+++ GK++AE LLS EE E P GLGRNEP+ L PNRP+ S ++PL+ + L+ +++W ++ + A+L + L +Y PG +++R++ Sbjct: 1036 EYDNFEDWLHTFNLLRGKIGDDDDTVSEEERIVGRFKGSMCVYKVPLPEDVTKEAGYDPNFGMFQGIPNNDPMNVLVRVYVVRATDLHPADINGKADPYVVIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGISKTYAIHGYNLWRDPVKPTQILSKLCKEGKIDGPHYGP----------------------GQKKQTDEHLALSVLQHWEDIPRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDMPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFLFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMAEPDVDLPMVSIFKQKRVKGWWPFVARNEND--EMELTGKVEAELHLLSAEEAEKTPAGLGRNEPDPLEKPNRPNPSLAWMLSPLRVVCVLLWRQYRWHVLGIIGSCAVLMFVALVLYTLPGAISERLI 1592
BLAST of Otoferlin vs. Ensembl Xenopus
Match: FER1L6 (fer-1-like family member 6 [Source:NCBI gene;Acc:100497075]) HSP 1 Score: 698.738 bits (1802), Expect = 0.000e+0 Identity = 405/1091 (37.12%), Postives = 598/1091 (54.81%), Query Frame = 3 Query: 741 QISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAI-------------------------KTVLRSESGGLPAGAK----------------------VYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGN------------RPKIPKWCHSTTEPMLPDTND--QEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR------PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 QI+IT+ EARQL G NI+P++ + IG+ K T V+ TN+P+YN+Y F+F + +LFD++IRL + ++LL LIG FR+D+ TVYN P H F KWA+L DP DI +G KGY+K D+++ GKG+ V+ K + +E IE NLL+P+ + +R A V+IY+AE LP+MN+ IMA + A GDSK LVDP+V V FAG GRT +KN P W+E+IVF EMFP LC R+++ V+D ++ + +ATH+IDL +I +E GD GFLPTFGP+W+NLYG+PRN T +M +ELN G GEGV++RGR+LI I K S+ G G K + VPP + K E FLL G+ +EA++ID +IG K I FE SVG GN LD ++ +K+ P G P++ S T P P D + Y +L F E+KPC+Y+ S D R + N+L+K+ + + +E + EL +M++ L FI + +++ + ++ T LDK+R+ L + LE M AK + Q K +L+ +E +++I + L+ PQ+ +PD+FIWL+ + KR+A+ARIPAR+ILYS + EE+G ++ T+F + PG+ P GW +Q ++ +YLWLG + + LP GY + PP ++Y + FQLRAHM+ AR LI +D SGLSD FA++ H TTK++ +TLSP W+Q L+ ++++ Y I +PP +V+E++D+D ++ KSE++G PTV L + Y +LT+ ++ G ++ GELLAAFEL+QV P+ G ++S PI T + + PVP IRP L YRVE LFWGVRE+++VQL+SVD+P++ IE + S VI S K PNF+ + ++ LPEN + PPL I D R FGR+ L+G H I+ + +++ K Sbjct: 20 QIAITITEARQLIGENIDPVVIIEIGDDKKQTTVKEGTNAPFYNEYFVFDFIGPQEQLFDKIIRLSVMH------NKLLGSILIGSFRVDLGTVYNEPGHQFCDKWALLTDPSDIRTGVKGYLKCDISVAGKGDTVQSSQKI------SDAEEQIEKNLLIPKGFPS--ERPWARFYVRIYRAEGLPKMNSSIMANVTKAFIGDSKDLVDPYVVVMFAGQMGRTTAQKNCADPLWHEQIVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISDEQDGDKGFLPTFGPAWINLYGSPRNTT---LMEDHQELNEGHGEGVSFRGRILIEIAVEILSGGAHESKFSKAIKDMKLPLKDSKSSKGSGKEKGEKGSEDAKPTSAVDKTNSIQVEVEPFDVPP--EFQEEKSEDFLLFGSIFEATLIDRKIGDKG--ISFECSVGNYGNVLDGVSHSGTKKKSPEHEDGEGAPLLQPEEGEAAPEVSLSFISVTTPEKPLITDGNRNYHYLPFYERKPCIYVKSTWGDQTFRLYSSNMLQKMADHLEDGLEQVKELVKISDLAPEEKMRDVLTEFINQSRAFISTAEKRSKMTNTTALDKKRVTLCRQELEAMSANAKAIVQQKKKMSLSDMTREMQSLIDNIKFLVDEPQHTVPDVFIWLLSNNKRVAYARIPARDILYSTLAEERGHHCGKIKTLFFKLPGK---RPPGWNVQAKVDVYLWLGSSKYSHFIFENLPGGYEVETHSASSGHHGSPPPGNLVYKSQHMFQLRAHMYQARGLIAADTSGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNNLVIYGELKDIAEDPPNIVIEVYDDDALS--------KSEYIGSTVASPTVILANQTYSPAKLTYHPLFCGNLSGGELLAAFELLQV-PESG-------------VQSLPPIE----------------------------------TPDAAQIYPVPSNIRPVLSKYRVEVLFWGVRELKKVQLLSVDRPQVLIECAGKGVKSCVIQSYKSNPNFNVIGDWFEVELPENEVLHPPLSICVVDWRAFGRSTLVGTHTINCLKQFLYK 1030 HSP 2 Score: 543.888 bits (1400), Expect = 2.159e-160 Identity = 279/592 (47.13%), Postives = 394/592 (66.55%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEES-SDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 ++Y LE EF+ F +++TF L +G+ DDE S D+RI+G FKG+ +IYK D+ + +L + + +P N V++L+R+Y++ +L PADP+GKSDPY++LRLG I +++NYIPKQLNP+FG+ FE+ FP++S L I + D D++ DD+IGETKIDLENR++S+H+A CGL +E GYN WRD PT +LAKLCK+ D P ++ + F +D+ E+ +S E LAL+ + +WS +P+ GC LVPEH+ETRPL++ +KPGI+QG ++MW+DMFP +L P P+DI+PR+P YELR+IIWNTEDVIL D + TG+KSSDI+VKGW+KG+ D Q TDVHY SL+GEGNFNWRF+F F Y+ AE +V +++ F++++TE K P L LQVWD D +++DDFLG +EL L+ RGAK+ + C L + ISIF+ KR RGWWPF E + GK++AEF L++ EE E PVG R EP L PNRP++SF F+NP K L +LI +K ++I L++ + LVLF Y PG ++ R+L Sbjct: 1177 LQIYSNELE--NEFKNFEDWVRTFELLRGKSTDDEHSVHDDRIIGKFKGSFSIYKNVDDTNPKDGG--QLRILQGIPPNHTVKVLIRVYIVAGFNLSPADPDGKSDPYIVLRLGKTEIKDRDNYIPKQLNPVFGRSFEMQATFPKDSILSIVIYDHDMIGTDDLIGETKIDLENRFFSRHRATCGLQSQYEIEGYNAWRDSTKPTEILAKLCKDNKLDGPYLRP--GQIQIGGKIFTGQTIFNQDD-EQVESYEHLALKALHSWSDIPDIGCNLVPEHIETRPLYHKDKPGIEQGRIQMWVDMFPTDLPLPGPPVDISPRKPKGYELRIIIWNTEDVILEDENIFTGQKSSDIYVKGWLKGIEDDSQETDVHYNSLTGEGNFNWRFVFPFSYLPAEKLMVVSKRENIFSLEKTERKIPTVLLLQVWDFDRLSSDDFLGSMELNLNAFHRGAKTAKGCDLSMAATPKDENKISIFQQKRIRGWWPFVKSGE-------LTGKVEAEFHLVTTEEAEKNPVGRARKEPEPLEKPNRPNTSFNWFVNPFKCLYHLIWRNYKKYIIIGLVLLIITLFLVLFFYTLPGAISNRILSG 1754
BLAST of Otoferlin vs. Ensembl Xenopus
Match: FER1L6 (fer-1-like family member 6 [Source:NCBI gene;Acc:100497075]) HSP 1 Score: 667.922 bits (1722), Expect = 0.000e+0 Identity = 396/1092 (36.26%), Postives = 584/1092 (53.48%), Query Frame = 3 Query: 741 QISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAI-------------------------KTVLRSESGGLPAGAK----------------------VYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFE-LSVGTTGNRLDSEANEEEEKEVPSVNQGN------------RPKIPKWCHSTTEPMLPDTND--QEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR------PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 QI+IT+ EARQL G NI+P++ + IG+ K T V+ TN+P+YN+Y F+F + +LFD++IRL + ++LL LIG FR+D+ TVYN P H F KWA+L DP DI +G KGY+K D+++ GKG+ V+ K + +E IE NLL+P+ + +R A V+IY+AE LP+MN+ IMA + A GDSK LVDP+V V FAG GRT +KN P W+E+IVF EMFP LC R+++ V+D ++ + +ATH+IDL +I +E GD GFLPTFGP+W+NLYG+PRN T +M +ELN G GEGV++RGR+LI I K S+ G G K + VPP + K E FLL G+ +EA++ID +IG K I FE +S G GN LD ++ +K+ P G P++ S T P P D + Y +L F E+KPC+Y+ S D R + N+L+K+ + + +E + EL +M++ L FI + +++ + ++ T LDK+R+ L C +++ V K L+ + PQ+ +PD+FIWL+ + KR+A+ARIPAR+ILYS + EE+G ++ T+F + PG+ P GW +Q ++ +YLWLG + + LP GY + PP ++Y + FQLRAHM+ AR LI +D SGLSD FA++ H TTK++ +TLSP W+Q L+ ++++ Y I +PP +V+E++D+D ++ KSE++G PTV L + Y +LT+ ++ G ++ GELLAAFEL+Q +G+Q S PI T + + PVP IRP L YRVE LFWGVRE+++VQL+SVD+P++ IE + S VI S K PNF+ + ++ LPEN + PPL I D R FGR+ L+G H I+ + +++ K Sbjct: 40 QIAITITEARQLIGENIDPVVIIEIGDDKKQTTVKEGTNAPFYNEYFVFDFIGPQEQLFDKIIRLSVMH------NKLLGSILIGSFRVDLGTVYNEPGHQFCDKWALLTDPSDIRTGVKGYLKCDISVAGKGDTVQSSQKI------SDAEEQIEKNLLIPKGFPS--ERPWARFYVRIYRAEGLPKMNSSIMANVTKAFIGDSKDLVDPYVVVMFAGQMGRTTAQKNCADPLWHEQIVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISDEQDGDKGFLPTFGPAWINLYGSPRNTT---LMEDHQELNEGHGEGVSFRGRILIEIAVEILSGGAHESKFSKAIKDMKLPLKDSKSSKGSGKEKGEKGSEDAKPTSAVDKTNSIQVEVEPFDVPPEVSFSVEKSEDFLLFGSIFEATLIDRKIGDKG--ISFEIISTGNYGNVLDGVSHSGTKKKSPEHEDGEGAPLLQPEEGEAAPEVSLSFISVTTPEKPLITDGNRNYHYLPFYERKPCIYVKSTWGDQTFRLYSSNMLQKMADHLEDGLEQVKELVKISDLAPEEKMRDVLTEFINQSRAFISTAEKRSKMTNTTALDKKRVTL---CRQELVVGPKRY---------------------NLSHFLAQPQHTVPDVFIWLLSNNKRVAYARIPARDILYSTLAEERGHHCGKIKTLFFKLPGK---RPPGWNVQAKVDVYLWLGSSKYSHFIFENLPGGYEVETHSASSGHHGSPPPGNLVYKSQHMFQLRAHMYQARGLIAADTSGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNNLVIYGELKDIAEDPPNIVIEVYDDDALS--------KSEYIGSTVASPTVILANQTYSPAKLTYHPLFCGNLSGGELLAAFELLQ----------SGVQ-------SLPPIE----------------------------------TPDAAQIYPVPSNIRPVLSKYRVEVLFWGVRELKKVQLLSVDRPQVLIECAGKGVKSCVIQSYKSNPNFNVIGDWFEVELPENEVLHPPLSICVVDWRAFGRSTLVGTHTINCLKQFLYK 1026 HSP 2 Score: 545.043 bits (1403), Expect = 4.484e-161 Identity = 280/591 (47.38%), Postives = 394/591 (66.67%), Query Frame = 3 Query: 4815 KVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEES-SDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 K+Y LE EF+ F +++TF L +G+ DDE S D+RI+G FKG+ +IYK D+ + +L + + +P N V++L+R+Y++ +L PADP+GKSDPY++LRLG I +++NYIPKQLNP+FG+ FE+ FP++S L I + D D++ DD+IGETKIDLENR++S+H+A CGL +E GYN WRD PT +LAKLCK+ D P ++ + F +D+ E+ +S E LAL+ + +WS +P+ GC LVPEH+ETRPL++ +KPGI+QG ++MW+DMFP +L P P+DI+PR+P YELR+IIWNTEDVIL D + TG+KSSDI+VKGW+KG+ D Q TDVHY SL+GEGNFNWRF+F F Y+ AE +V +++ F++++TE K P L LQVWD D +++DDFLG +EL L+ RGAK+ + C L + ISIF+ KR RGWWPF E + GK++AEF L++ EE E PVG R EP L PNRP++SF F+NP K L +LI +K ++I L++ + LVLF Y PG ++ R+L Sbjct: 1137 KIYSNELE--NEFKNFEDWVRTFELLRGKSTDDEHSVHDDRIIGKFKGSFSIYKNVDDTNPKDGG--QLRILQGIPPNHTVKVLIRVYIVAGFNLSPADPDGKSDPYIVLRLGKTEIKDRDNYIPKQLNPVFGRSFEMQATFPKDSILSIVIYDHDMIGTDDLIGETKIDLENRFFSRHRATCGLQSQYEIEGYNAWRDSTKPTEILAKLCKDNKLDGPYLRP--GQIQIGGKIFTGQTIFNQDD-EQVESYEHLALKALHSWSDIPDIGCNLVPEHIETRPLYHKDKPGIEQGRIQMWVDMFPTDLPLPGPPVDISPRKPKGYELRIIIWNTEDVILEDENIFTGQKSSDIYVKGWLKGIEDDSQETDVHYNSLTGEGNFNWRFVFPFSYLPAEKLMVVSKRENIFSLEKTERKIPTVLLLQVWDFDRLSSDDFLGSMELNLNAFHRGAKTAKGCDLSMAATPKDENKISIFQQKRIRGWWPFVKSGE-------LTGKVEAEFHLVTTEEAEKNPVGRARKEPEPLEKPNRPNTSFNWFVNPFKCLYHLIWRNYKKYIIIGLVLLIITLFLVLFFYTLPGAISNRILSG 1713
BLAST of Otoferlin vs. Ensembl Mouse
Match: Otof (otoferlin [Source:MGI Symbol;Acc:MGI:1891247]) HSP 1 Score: 861.292 bits (2224), Expect = 0.000e+0 Identity = 480/1305 (36.78%), Postives = 748/1305 (57.32%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIY-FGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGM--GSDKRTLI---------------------------DPQ-TGEIGEFNYGQTDNESIESGE----DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV---PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L + DRI K+ FR ++V+ + + F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ ++ + L+D +++II+ ++S E+ Y + D + W +F + D L + D S ++ G+ GS T I +PQ E D+ +I+ G+ D S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI +G KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RL++ + +L + + L + +V P+S+ G+ E F L GAF EAS+ID + G K PI FE+++G GN +D E +EEE ++ S ++G+ S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +AK++ + + +L+ C+ ++KL L PQ+ +PD+FIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q +L++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALIVHLKTVSELRGKGDRIAKVTFRGQSFYSRVLENCEGVADFDETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFCMVLQKVVEENRVEVTDTLMDDSNAIIKTSLSMEVRYQATDGTVGPWDDGDF---LGDESLQEEKD-SQETDGLLPGSRPSTRISGEKSFRRAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIQLGDGLDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGDK--PITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASV-SSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRSCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQIGPSGKADLP-------------------------------------PINGPVDMDRGP--------IMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1231 HSP 2 Score: 639.032 bits (1647), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 424/598 (70.90%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVRIYV+RA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCKE D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVI+WNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD+SF+ F+NPLKS +Y + + ++W L+K L++ LL L LF+Y+ PGYLAK++LGA Sbjct: 1405 IDELKVYPKELE--SEFDSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDPTYGMFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHF-GPHGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKFLLLFLLLLLFALFLYSLPGYLAKKILGA 1997
BLAST of Otoferlin vs. Ensembl Mouse
Match: Otof (otoferlin [Source:MGI Symbol;Acc:MGI:1891247]) HSP 1 Score: 860.136 bits (2221), Expect = 0.000e+0 Identity = 481/1320 (36.44%), Postives = 751/1320 (56.89%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIY-FGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGM--GSDKRTLIDPQT------------GEIGEFNYGQT-------------------------------DNESIESGE----DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV---PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L + DRI K+ FR ++V+ + + F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ ++ + L+D +++II+ ++S E+ Y + D + W +F + D L + D S ++ G+ GS T I + G GE G++ D+ +I+ G+ D S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI +G KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RL++ + +L + + L + +V P+S+ G+ E F L GAF EAS+ID + G K PI FE+++G GN +D E +EEE ++ S ++G+ S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +AK++ + + +L+ C+ ++KL L PQ+ +PD+FIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q +L++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALIVHLKTVSELRGKGDRIAKVTFRGQSFYSRVLENCEGVADFDETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFCMVLQKVVEENRVEVTDTLMDDSNAIIKTSLSMEVRYQATDGTVGPWDDGDF---LGDESLQEEKD-SQETDGLLPGSRPSTRISGEKSFRSKGREKTKGGRDGEHKAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIQLGDGLDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGDK--PITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASV-SSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRSCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQIGPSGKADLP-------------------------------------PINGPVDMDRGP--------IMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1246 HSP 2 Score: 646.351 bits (1666), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 425/598 (71.07%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVRIYV+RA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCKE D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVI+WNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD++F+ F+NPLKS+KYLIC ++KW +IK ++ L +L LF+Y+ PGY+ K++LGA Sbjct: 1400 IDELKVYPKELE--SEFDSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDPTYGMFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHF-GPHGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLALFLYSLPGYMVKKLLGA 1992
BLAST of Otoferlin vs. Ensembl Mouse
Match: Fer1l6 (fer-1-like 6 (C. elegans) [Source:MGI Symbol;Acc:MGI:3645398]) HSP 1 Score: 701.434 bits (1809), Expect = 0.000e+0 Identity = 415/1137 (36.50%), Postives = 625/1137 (54.97%), Query Frame = 3 Query: 618 GQTDNESIESGEDDESF-----AATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRS------------------------------------------------ESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANE---------EEEKEVPSVNQGNRPKIPKWC---HSTTEPMLPDTND--QEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAK-TMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSND----CFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 G + E E D++F +A + R + +H K++++QI++T+ EARQL G NI+P++ + IG+ K + V+ TNSP+YN+Y F+F + LFD++I++ L +L+ LIG FR+DV TVYN P H F KWA+L DP DI +G KGY+K D+++ GKG+ +K PK+ + +E IE NLL+PQ + +R A V++Y+AE LP+MN+ IMA + A GDSK LVDPFV+VSFAG TGRT V+KN P W+E++VF EMFP LC R+++ V+D ++ + +ATH+IDL +I NE GD GFLPTFGP+W+NLYG+PRN++ +M +ELN G GEGV++RGR+L+ I + S ++ + ++VPP + K E FLL GAF+EA++ID +IG K PI FE+SVG GN +D ++ EE +P +++G + STT P P D + Y +L F KKPC+ IS D R N+LEK+ + +E + EL + +MK AL FI ++ + +T LDK+R+ L L+ M +A+ + Q K +L ++E + ++K++ L+ PQ+ +PD+FIW++ + KR+A+ARI A+++LYS I E+ G ++ T FL+ PG+ P GWT+Q ++ +YLWLG R T LP+GY + PP ++Y + FQLRAHM+ AR LI +D +GLSD FA++ TTK++ +TLSP W+Q L+ + ++ + + ++ +PP +VVE++D D + GK E+LG P V L +++Y+ P+L++ I+ G ++ G+LLA FEL+QV P +G+Q + P G D+T + PVP IRP L YRVE LFWGVREM++VQL+SVD+P++ IE G + S VI S K PNFS + ++ LPEN L PPL I D R FGR+ L+G + I+ + +++ K Sbjct: 37 GPSHQEGPEDLTKDDAFLAPGPSAPSKRRAKLLTKIHDGEIKSQNYQITVTITEARQLVGENIDPVVTIEIGDDKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVLH------HKLIGSILIGSFRVDVGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDILKTNPKT------SDAEEQIEKNLLIPQGFPS--ERPWARFYVRLYRAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTSVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHS---LMDDYQELNEGFGEGVSFRGRILVEIAVEILSGGAQESKFSKALKELKLSSKDKDSKSSKGSSKDKADKADDSKAQQTTDKTNSTEVEVESFAVPP--EIIPEKYEDFLLFGAFFEATMIDRKIGDK--PISFEVSVGNFGNLIDGGSHHGSKKKSTELTEEDVLPLLHEGEKDVAQDSAISMASTTHPEKPLVTDGNRNYNYLPFGAKKPCVSFISSWGDQTFRLHWSNMLEKMADLLEEGIEEVRELVKVSQEAPEEKMKTALRDFITQSRVFISEAEKKPKTLNQTALDKKRLTLCWQELKAMADEAEGVIRQQKKKLSLDEMIREAQNFVEKIHFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPIEEQMGKHCGKIKTHFLKLPGK---RPPGWTVQAKVDIYLWLGSTRYSNTILDNLPVGYEAEMPPKSSGTHHPPSALLYQAQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSQCQTTKIISQTLSPTWNQMLLFNELVLHGEEKELLESPPHVVVELYDSDAV--------GKPEYLGATVAAPVVTLADQDYEPPKLSYHPIFCGNLSGGDLLAVFELLQVPP-------SGLQGL-------PPTGP----------------------PDITQ------------IYPVPSNIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECGGGGVKSCVIQSYKNNPNFSVQAEAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINCLKQFLCK 1093 HSP 2 Score: 544.658 bits (1402), Expect = 4.532e-160 Identity = 280/591 (47.38%), Postives = 396/591 (67.01%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD-NRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEI-EEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 K+Y LE EF F +++TF L +G+ +++ D +R++G FKG+ IYK ++ + +L + + +P N PVQ+L+R+Y++ A +L PADP+GKSDPY++LRLG I +++ YIPKQLNP+FG+ FE+ FP+ES L + + D D++ DD+IGETKIDLENR+YSKH+A+CGL +E GYN WRD PT +L KLCK+ D P + K+ + + F EED+ E +S E LAL+V+ +W +P G LVPEH+ETRPL++ +KPG++QG L+MW+DMFPK+ P+DI+PR+P YELRV IWNTEDVIL D + TG+KSSDI+VKGW+KGL D Q TDVHY SL+GEGNFNWRF+F F Y+ AE ++V +++ F++++ E K+P L LQVWD + +++DDFLG LE+ L+ PR AKS + C L + + ISIF+ KR RGWWPF K ++ GK++AEF L++ EE E PVG R EP L PNRPD+SF F++P K L +LI +K ++I A I+ L+ LVLFIY PG +++R++ Sbjct: 1281 LKIYDGDLE--SEFNNFEDWVKTFELFRGKSTEEDHGLDGDRVIGKFKGSFCIYKSPEDSTSEDSG--QLRIQQGIPPNHPVQVLIRVYIVAAFNLSPADPDGKSDPYIVLRLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDMIGSDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRP--GKIQIGKKVFSGKTVFNEEDSEEMVESYEHLALKVLHSWEDIPEAGWRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDTPQLGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWIKGLEDDRQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLSKFENAVQENKISIFQQKRVRGWWPFA-------KSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFVSPFKCLYHLIWKNYKKYIIIAFILIILIVFLVLFIYTLPGAISRRIV 1858
BLAST of Otoferlin vs. Ensembl Mouse
Match: Fer1l6 (fer-1-like 6 (C. elegans) [Source:MGI Symbol;Acc:MGI:3645398]) HSP 1 Score: 701.434 bits (1809), Expect = 0.000e+0 Identity = 415/1137 (36.50%), Postives = 625/1137 (54.97%), Query Frame = 3 Query: 618 GQTDNESIESGEDDESF-----AATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRS------------------------------------------------ESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANE---------EEEKEVPSVNQGNRPKIPKWC---HSTTEPMLPDTND--QEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAK-TMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSND----CFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 G + E E D++F +A + R + +H K++++QI++T+ EARQL G NI+P++ + IG+ K + V+ TNSP+YN+Y F+F + LFD++I++ L +L+ LIG FR+DV TVYN P H F KWA+L DP DI +G KGY+K D+++ GKG+ +K PK+ + +E IE NLL+PQ + +R A V++Y+AE LP+MN+ IMA + A GDSK LVDPFV+VSFAG TGRT V+KN P W+E++VF EMFP LC R+++ V+D ++ + +ATH+IDL +I NE GD GFLPTFGP+W+NLYG+PRN++ +M +ELN G GEGV++RGR+L+ I + S ++ + ++VPP + K E FLL GAF+EA++ID +IG K PI FE+SVG GN +D ++ EE +P +++G + STT P P D + Y +L F KKPC+ IS D R N+LEK+ + +E + EL + +MK AL FI ++ + +T LDK+R+ L L+ M +A+ + Q K +L ++E + ++K++ L+ PQ+ +PD+FIW++ + KR+A+ARI A+++LYS I E+ G ++ T FL+ PG+ P GWT+Q ++ +YLWLG R T LP+GY + PP ++Y + FQLRAHM+ AR LI +D +GLSD FA++ TTK++ +TLSP W+Q L+ + ++ + + ++ +PP +VVE++D D + GK E+LG P V L +++Y+ P+L++ I+ G ++ G+LLA FEL+QV P +G+Q + P G D+T + PVP IRP L YRVE LFWGVREM++VQL+SVD+P++ IE G + S VI S K PNFS + ++ LPEN L PPL I D R FGR+ L+G + I+ + +++ K Sbjct: 37 GPSHQEGPEDLTKDDAFLAPGPSAPSKRRAKLLTKIHDGEIKSQNYQITVTITEARQLVGENIDPVVTIEIGDDKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVLH------HKLIGSILIGSFRVDVGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDILKTNPKT------SDAEEQIEKNLLIPQGFPS--ERPWARFYVRLYRAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTSVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHS---LMDDYQELNEGFGEGVSFRGRILVEIAVEILSGGAQESKFSKALKELKLSSKDKDSKSSKGSSKDKADKADDSKAQQTTDKTNSTEVEVESFAVPP--EIIPEKYEDFLLFGAFFEATMIDRKIGDK--PISFEVSVGNFGNLIDGGSHHGSKKKSTELTEEDVLPLLHEGEKDVAQDSAISMASTTHPEKPLVTDGNRNYNYLPFGAKKPCVSFISSWGDQTFRLHWSNMLEKMADLLEEGIEEVRELVKVSQEAPEEKMKTALRDFITQSRVFISEAEKKPKTLNQTALDKKRLTLCWQELKAMADEAEGVIRQQKKKLSLDEMIREAQNFVEKIHFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPIEEQMGKHCGKIKTHFLKLPGK---RPPGWTVQAKVDIYLWLGSTRYSNTILDNLPVGYEAEMPPKSSGTHHPPSALLYQAQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSQCQTTKIISQTLSPTWNQMLLFNELVLHGEEKELLESPPHVVVELYDSDAV--------GKPEYLGATVAAPVVTLADQDYEPPKLSYHPIFCGNLSGGDLLAVFELLQVPP-------SGLQGL-------PPTGP----------------------PDITQ------------IYPVPSNIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECGGGGVKSCVIQSYKNNPNFSVQAEAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINCLKQFLCK 1093 HSP 2 Score: 544.658 bits (1402), Expect = 4.532e-160 Identity = 280/591 (47.38%), Postives = 396/591 (67.01%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD-NRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEI-EEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 K+Y LE EF F +++TF L +G+ +++ D +R++G FKG+ IYK ++ + +L + + +P N PVQ+L+R+Y++ A +L PADP+GKSDPY++LRLG I +++ YIPKQLNP+FG+ FE+ FP+ES L + + D D++ DD+IGETKIDLENR+YSKH+A+CGL +E GYN WRD PT +L KLCK+ D P + K+ + + F EED+ E +S E LAL+V+ +W +P G LVPEH+ETRPL++ +KPG++QG L+MW+DMFPK+ P+DI+PR+P YELRV IWNTEDVIL D + TG+KSSDI+VKGW+KGL D Q TDVHY SL+GEGNFNWRF+F F Y+ AE ++V +++ F++++ E K+P L LQVWD + +++DDFLG LE+ L+ PR AKS + C L + + ISIF+ KR RGWWPF K ++ GK++AEF L++ EE E PVG R EP L PNRPD+SF F++P K L +LI +K ++I A I+ L+ LVLFIY PG +++R++ Sbjct: 1281 LKIYDGDLE--SEFNNFEDWVKTFELFRGKSTEEDHGLDGDRVIGKFKGSFCIYKSPEDSTSEDSG--QLRIQQGIPPNHPVQVLIRVYIVAAFNLSPADPDGKSDPYIVLRLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDMIGSDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRP--GKIQIGKKVFSGKTVFNEEDSEEMVESYEHLALKVLHSWEDIPEAGWRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDTPQLGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWIKGLEDDRQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLSKFENAVQENKISIFQQKRVRGWWPFA-------KSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFVSPFKCLYHLIWKNYKKYIIIAFILIILIVFLVLFIYTLPGAISRRIV 1858
BLAST of Otoferlin vs. Ensembl Mouse
Match: Fer1l4 (fer-1-like 4 (C. elegans) [Source:MGI Symbol;Acc:MGI:1921812]) HSP 1 Score: 591.267 bits (1523), Expect = 1.914e-175 Identity = 378/1317 (28.70%), Postives = 639/1317 (48.52%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDR----------KLSDADDISIDSHGMGSDKRTL--IDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLP--GDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEG-DTGFLPTFGPSWVNLYGT-PRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAI--------------KTVLRS----------------ESGGLPAG---------------------AKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLD-----SEANEEEEKE-------VPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKG 3809 MAL + ++++ L DR +++ FR F + T+ + GE F+WP ++L +++ S+ + + +G++ ISLQ+L + +E L+D + I V +L Y P+ W +++F PI D + + + ++ + +R + Q E E E + F+ +R LG+P + K +D+Q+ +TV+EA++L G NINP + VR+G++ K T TN P+YN+Y FEFH ++ L D ++ + S+ LP IG FRMD+ + PD F KWA L DP+D +G KG+VK+ L++ +G+ P DIE NLLLP ++ +R A + V++Y+AE LP + T ++ ++ A+ D L+DP+V+VSF G G T V+ P+WNE++ F E+FP L +R+ + D + + +ATH +DL QI N G GF PTFGP+WV LYG+ P D + + LN GLGEG+ +RGRLL+A+ +T RS G PAG +V + P+ + E FLL G +EA++ID + KK PI E+S+G G + + S A+E E + S ++G + + + + P + Y L +KPCL++ S ED+ R N + K+ + ++ + ++ G R+K L+ + + + R ++ LD+ R KL L M + + + N+ + + ++ +L L PQ LPD+ +W+ +R+A+ARIPA++ILYS + EE+G ++ ++ L P G P + +L+++LWLGL + K LP+ + P + + YFQLRAH++ AR ++ +D+SGLSD FAR+L++ TT+V+ +TLSP WD+ L+ D +I ++ + PP++V+ +FD N+ G + FLGR F P V L E+ Y+ P L ++ + +G AGE++A FELI++ Y ++E + DV P + ++ + +P +RP L +RVE LFWG+R + RV L ++KP++ +E + S+V+P+ + PNF+ ++++ + LPE PPL I + R FGRT+L+G+H++ ++ +++++G Sbjct: 1 MALTVCVRHLTGLPGTHDRQVRLCFRGFTQKTRKIHCGREADVGELFRWPHYGSPLAGESLSVQVVNCSRVFSPRPLGTLVISLQQLQSAGHLVLREALVDERLRVSPIQVELDLKYQPPEGAAGTWAEEDFGTPIRDSLELIIPNVGFQDMEPGEAQLERRAVALGRRLARSLGTQDDEENELELEPELEEEPDVEISGVVFSPLKSRALGLPRGDPFKVCKAQDFQVGVTVLEAQKLVGVNINPYVAVRVGDQRKVTATLRGTNCPFYNEYFLFEFHETRLHLQDLLLEITAFH------SQTLPFMATRIGTFRMDLGMALDQPDGHFHQKWAPLHDPRDTRAGTKGFVKITLSVRARGDLPLPPPPPCP-----GTSSDIEKNLLLPHGVQ--AERPWARLRVRVYRAEGLPTVRTGLLGSLARALH-DQNVLLDPYVRVSFLGQQGETSVRGEETAPKWNEQLSFVELFPPLTRSLRLQLRDNAPLVDVALATHVLDLRQISNSGRAAGFNPTFGPAWVPLYGSLPSGRLRDDL----QSLNEGLGEGIWFRGRLLVAVSMEVYEGRVEPKPSQTTQRSGLSRLTGKKKKKKEKTRQGQTPAGILQPASASTSEDAPEIPSAMEVEVEDLLPLPENALASFEDFLLFGVLFEATMIDPSLAKK--PISLEISIGHAGRQEEQSGQGSRADEGSESSTLEVQPLLESEDRGAGQEEQELLGTPAQWPEPVDGNGPYLCLPLRHRKPCLHVWSCWEDYTWRLQSSNSVCKVAERLDHGLQEVEKMQRRSGPGACTRLKQTLEELVAGSRQFCHGAE-RRTMTRPNALDRCRAKLLTHSLNLMARQGLRLLRSLRLNNMQRTVVLAKKLLARLRFLAQEPQPPLPDVLVWMFSGQRRVAYARIPAQDILYSVVEEERGRDCGKIQSLLLTVP---GAAPG--EVCAKLELFLWLGLGKQAKACTSELPMDLLPEPSSGL--PQSLYRDDFRYFQLRAHLYQARGVLAADDSGLSDPFARVLISTQCQTTRVLEQTLSPLWDELLVFDQLIVDGRREHLREEPPLVVINVFDH--------NKFGPAVFLGRAFAAPRVKLIEDPYQRPELQFFPLRKGPQAAGEVIATFELIEL----DYS----------------------------------GHLEPSVPSDVEPRDLASLVEPISGHLSLPPSVRPVLRAFRVEVLFWGLRGLGRVHLFEIEKPQVVLEVAGRRVESEVLPNYRENPNFTELVRHVTVDLPEQPYLQPPLSILVIERRAFGRTVLVGSHIVPHMLRFILQG 1243 HSP 2 Score: 501.901 bits (1291), Expect = 5.284e-145 Identity = 266/599 (44.41%), Postives = 364/599 (60.77%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEES--SDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEK-----KQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFT--GENED---------------------DPKELD----------VNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKF 6476 I K+Y LE+ EF F ++ FPL +G+ D E + VG FKG+ IY + + + + + +P N P+++LVR+Y+++A +L PADPNGK+DPY+++ G + + KE YIPKQLNPIFG+ EL V P + L + V D DLV DD+IGET IDLENR+YS H+A CGL ++ +GYN WRD P+ +LA LC+ G P+Y A V V F +E + K + S E AL V++ W ++P G LVPEH+ETRPL++ PG+ QGSL MWID+FP ++ APP P+DI PRQPISYELRV+IWNT+DV L D LTGE+SSDI+VK W+KGL D Q TDVH+ SL+GEGNFNWRF+F FDY+ E ++ + K PFA++E E + P L LQVWD D ++A+DFLG LEL L + RGA+ P+ C + +L DG+ ++F+ R RGWWP + ED P++L+ + GK++AEF+LL+ EE E PVG GR EP L PNRP +SF F+NPLK+ + I ++ Sbjct: 1368 IATLKIYNSSLED--EFSHFEDWLSVFPLYRGQGGQDGEGEGASGHFVGKFKGSFLIYPESEAKSFS-----EPQISRGVPQNRPIKLLVRVYIVKATNLAPADPNGKADPYVVVSAGKEQRDTKERYIPKQLNPIFGEVLELSVSLPAQPELTVAVFDHDLVGSDDLIGETHIDLENRFYSHHRANCGLASQYDVNGYNAWRDAFRPSQILAGLCQRCGLPVPEYRA--GAVKVGSRVFLTPSEAPPPDDRKPKVTSEASEEAQALHVLRRWQEMPGLGIQLVPEHVETRPLYHPRSPGLLQGSLHMWIDIFPSDVPAPP-PVDIKPRQPISYELRVVIWNTDDVALDDVNPLTGERSSDIYVKSWVKGLEQDRQETDVHFNSLTGEGNFNWRFVFRFDYLPTEREVSVRRKPGPFALEEAEFRQPAVLVLQVWDYDRISANDFLGSLELQLPDMVRGARDPEHCSV-RLALDGAGPRCNLFRCHRLRGWWPVVKMKDMEDVEREAREAQAGKKRKRKRRAGRPEDLEFTDTGGNVYILTGKVEAEFELLTVEEAEKRPVGKGRKEPEPLEKPNRPKTSFNWFVNPLKTFIFFIWRRY 1955
BLAST of Otoferlin vs. UniProt/SwissProt
Match: sp|Q5SPC5|OTOF_DANRE (Otoferlin OS=Danio rerio OX=7955 GN=otof PE=3 SV=1) HSP 1 Score: 871.307 bits (2250), Expect = 0.000e+0 Identity = 490/1320 (37.12%), Postives = 747/1320 (56.59%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF---------------ENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQT----------DNESIESGEDDE---------------SFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVYSVPP--ISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEA-------------------------NEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKF----RRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 MALV++LK V L + DRI K+ FR ++V+ +D F + F+WP+G ++D + LE++++ YSK N+LIG+ + LQK++E+ + + LID N++ I+ T+S E+ Y + D + W EF ++ ++ R S HG+ + ++ G G+T D+ +I ED + S A+ A T V + + P+ + D+QIS+TVIEARQL G N++P++ V IGE+ K T ++ STN PYYN+Y F+FH+ +FD++I++ + N+ L G L+G F++DV TVY P+H F HKWAML DP DI +G KGYVK D+ ++GKG+ +K K++ + D++DIE NLLLP+ + + +RQ A VKIY+AE LP+MNT IMA +K A G+++ LVDP+V V FAG G+T V+K++Y P WNE+++FTEMFP LC R++V + D D V + I TH+IDL ++ N+GD GFLPT GP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLLI+I +L + S + + +V+ P IS+ GK E F L G+F EA++ID +IG K PI FE+++G GN++D + + EEE E + G+ +P +T PM P D+ YFHL + EKKPC+Y+ S+ +D + R + NI++K+ ++ + + E+ E+ R++ L+ + + +++S +T LD+ER+K +E M +AKT+ + + +LK +++L L PQ+ +PD+FIW+I + KR+A+ARIP+++ILYS + EE G +V VFL+ PG+ G GP+GWT+Q +L+MYLWLGL + K F GLP G+ N K PP+ ++Y K FQLRAHM+ AR+L +D SGLSD FAR+ + H T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK+EF+GR F KP + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P R A L ++G + D P ++PVP IRP L YR+E LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR IL+G+H ++ + K++ Sbjct: 1 MALVVHLKTVTELRGKGDRIAKVTFRGLSFFSRVLENCEDEARFEQAFRWPIGSQVDGDEMLEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTTISIEIKYQTMDGSVKVWSDGEFLDIPDDLDGTFQFETDSLLSGRSQSSGTSPGRSIHGIPTFRKA----GKGVFSAMKLGKTRTSKDDHKKGDDAAILDAEDLDRKAMRLGGILDPDTISLASVTAVTTNVSNKRSKPDIKMEPSSGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKISVIHSKNL----LRSGTLVGTFKLDVGTVYTQPEHQFHHKWAMLSDPDDITTGCKGYVKCDIAVVGKGDNIKTPHKAS-----EADEDDIEGNLLLPEGVPS--ERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVLVQFAGQKGKTSVQKSSYEPIWNEQVIFTEMFPPLCRRLKVQIRDSDKVNDVAIGTHFIDLRKVSNDGDKGFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISIAVEILDTTSAEIMSSTEVHMEPVSNISESATGKMEEFFLFGSFLEATMIDRKIGDK--PISFEVTIGNYGNQIDGVSKPALAKKKKEGGGESEEEESELIHNSSEEEAE----DDGDLTSVP-----STPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEIIKTEKAYPERRLRGVLEELSTSCSRFVTLANKDQNLSGRTKLDRERLKSCMREMESMGQQAKTIRTQVKRNTVRDKLKLVLNFLQRLRFLADEPQHSIPDVFIWMISNNKRIAYARIPSKDILYSIVDEEMGKDCGKVKAVFLRLPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLIGLPSGFEENKAVKGIGIQAVPPISLVYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEAGELRDDPPIIVIELYDQDTV--------GKAEFIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCAAGDLLAAFELLQIGP--AGRAA-------------------------------LPPIDGPTDSDRGP------------ILPVPLGIRPVLSRYRIEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGSHAVTTLRKFI 1238 HSP 2 Score: 645.966 bits (1665), Expect = 0.000e+0 Identity = 325/599 (54.26%), Postives = 428/599 (71.45%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS---DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 ++ VY LE EF F ++ TF L +G+ DD++ + ++RIVG FKG+L +YK+ E + +++S+P+NDP+ +LVRIY+IRA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + HGYN WRD Q P +LAKLCKE D P Y +V VA F EIE+++G KKQ+ E LAL V+++W ++P GC L+PEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L+K PRGAK+ + C L + K+ + TISIFK KR +GWWPF +NE+D E ++ GK++AE LL+ EE E PVGLGRN+P L PNRPD+S + FMNPL+S++Y I + ++W ++KAL + LL L+ LF+Y+ PGYL K++LGA Sbjct: 1399 VDELMVYNKELE--SEFGSFEDWLHTFNLYRGKAGDDDDHNVVDEDRIVGRFKGSLCMYKLPLSEEITREAGFDPNMGMFQSIPHNDPINVLVRIYIIRATDLHPADINGKADPYIVIKLGKSDIRDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSVHGYNVWRDPQKPAQILAKLCKEGKLDGPHY-GPGGRVKVANRIFLGPTEIEDESGLKKQTEEHLALTVLRHWEEIPRVGCKLIPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDVPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNKFPRGAKTAKQCSLDMVLKEHELPTISIFKQKRVKGWWPFVAQNEND--EFELTGKVEAELHLLTAEEAEKSPVGLGRNDPEPLEKPNRPDTSLMWFMNPLRSIRYFIWHNYRWLILKALALLLLLLLVGLFLYSIPGYLVKKLLGA 1992
BLAST of Otoferlin vs. UniProt/SwissProt
Match: sp|Q9ERC5|OTOF_RAT (Otoferlin OS=Rattus norvegicus OX=10116 GN=Otof PE=1 SV=2) HSP 1 Score: 862.448 bits (2227), Expect = 0.000e+0 Identity = 479/1324 (36.18%), Postives = 744/1324 (56.19%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDE-----------------------------------------------------SFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV---PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L R DRI K+ FR ++V+ +D F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ ++ + LID N++II+ ++S E+ Y + D + W +F + D L + + S ++ G+ R P T GE ++ E + G D E S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI +G KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RL++ + +L + + L + +V P+S+ G+ E F L GAF EAS+ID + G K P+ FE+++G GN +D E +EEE ++ S ++G+ S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +AK++ + + +L+ C+ ++KL L PQ+ +PD+FIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q +L++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D +GLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALIVHLKTVSELRGRADRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFRMVLQKVVEENRVEVSDTLIDDNNAIIKTSLSMEVRYQAADGTVGPWDDGDF---LGDESLQEEEKDSQETDGLLPGSR----PSTRTPGEKSFRSKGKEKTKGGRDGEHKAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGDK--PVTFEVTIGNYGNEVDGTSRPQRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASV-SSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGHSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQTFQLRAHMYQARSLFAADSTGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPSGKADLP-------------------------------------PINGPVDMDRGP--------IMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1247 HSP 2 Score: 646.351 bits (1666), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 425/598 (71.07%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVRIYV+RA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCKE D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVI+WNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD++F+ F+NPLKS+KYLIC ++KW +IK ++ L +L LF+Y+ PGY+ K++LGA Sbjct: 1401 IDELKVYPKELE--SEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDPTYGMFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHF-GPHGRVKVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLALFLYSLPGYMVKKLLGA 1993
BLAST of Otoferlin vs. UniProt/SwissProt
Match: sp|Q9HC10|OTOF_HUMAN (Otoferlin OS=Homo sapiens OX=9606 GN=OTOF PE=1 SV=3) HSP 1 Score: 860.522 bits (2222), Expect = 0.000e+0 Identity = 478/1306 (36.60%), Postives = 738/1306 (56.51%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF--------------------------ENPITDRKLSDADDISIDSHGMGSDKRTLIDPQT-GEIGEFNYGQTDNESIESGE----DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV-------PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L R DRI K+ FR ++V+ +D F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ + + LID N++II+ ++ E+ Y + D + W +F P ++ A + +G ++ +PQ E D+ +I G+ D S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI SG KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RLL+ + ++ + + L + +V PIS+ GK E F L GAF EAS+ID G K PI FE+++G GN +D E +EEE ++ + + G+ + S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +A+ + + + +L+ C+ ++KL L PQ+ +PDIFIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q ++++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDK--PITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASV-----SSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP-------------------------------------PINGPVDVDRGP--------IMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1232 HSP 2 Score: 637.106 bits (1642), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 424/598 (70.90%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLM--LYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVR+YV+RA DLHPAD NGK+DPY+ +RLG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCK+ D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVIIWNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD+SF+ F+NPLKS +Y + + ++W L+K L++ LL LL LF+Y+ PGYL K++LGA Sbjct: 1405 IDELKVYPKELE--SEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHF-GPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1997
BLAST of Otoferlin vs. UniProt/SwissProt
Match: sp|Q9ESF1|OTOF_MOUSE (Otoferlin OS=Mus musculus OX=10090 GN=Otof PE=1 SV=1) HSP 1 Score: 859.751 bits (2220), Expect = 0.000e+0 Identity = 480/1305 (36.78%), Postives = 748/1305 (57.32%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIY-FGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGM--GSDKRTLI---------------------------DPQ-TGEIGEFNYGQTDNESIESGE----DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS-----------EANEEEEKEV---PSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK 3806 MAL+++LK V L + DRI K+ FR ++V+ + + F E F+WP+ +D + LE++++ YSK +NKLIG+ + LQK++E+ ++ + L+D +++II+ ++S E+ Y + D + W +F + D L + D S ++ G+ GS T I +PQ E D+ +I+ G+ D S A+ A T V + + P+ + D+Q+SITVIEARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+S +FD++I++ + N+ L G L+G F+MDV TVY+ P+H F HKWA+L DP DI +G KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ + +RQ A VKIY+AE LPRMNT +MA +K A G++K LVDP+VQV FAG G+T V+K++Y P WNE++VFT++FP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT ++ ++LN GLGEGV++R RL++ + +L + + L + +V P+S+ G+ E F L GAF EAS+ID + G K PI FE+++G GN +D E +EEE ++ S ++G+ S+T PM P D+ YFHL + E+KPC+Y+ S+ D + R + NI++ + ++ + + E+ E+ R++ L+ L+ + S +T LD+ER+K LE M +AK++ + + +L+ C+ ++KL L PQ+ +PD+FIW++ + KR+A+AR+P++++L+S + EE G ++V T+FL+ PG+ G G +GWT+Q +L++YLWLGL + K F GLP G+ + PP+ ++YT+K FQLRAHM+ AR+L +D SGLSD FAR+ + T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D M GK++F+GR F KP V + +E Y PR L +++IYRG AG+LLAAFEL+Q+ P L ING V + G ++PVP IRP L YRVE LFWG+R+++RV L VD+PR+ IE + S +I + K PNF+ +K+ ++ LPEN L PPL I+ D R FGR L+G+H +S++ +++ + Sbjct: 1 MALIVHLKTVSELRGKGDRIAKVTFRGQSFYSRVLENCEGVADFDETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFCMVLQKVVEENRVEVTDTLMDDSNAIIKTSLSMEVRYQATDGTVGPWDDGDF---LGDESLQEEKD-SQETDGLLPGSRPSTRISGEKSFRRAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIQLGDGLDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNL----LRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPP--ERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGDK--PITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASV-SSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSM--------GKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQIGPSGKADLP-------------------------------------PINGPVDMDRGP--------IMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYR 1231 HSP 2 Score: 638.647 bits (1646), Expect = 0.000e+0 Identity = 316/598 (52.84%), Postives = 424/598 (70.90%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS--DNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 I+ KVYP LE EF+ F ++ TF L +G+ DDE+ S + RIVG FKG+L +YKV E + +++ +P+NDP+ +LVRIYV+RA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSKH+A CG+ Q + HGYN WRD P+ +L +LCKE D P + +V VA F +EIE++NG++K ++E +AL +++W +P GC LVPEH+ETRPL N +KPGI+QG LE+W+DMFP ++ AP P+DI+PR+P YELRVI+WNT++V+L D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWR++F FDY+ AE+KIV K+S F+ DETE K P +L LQ+WDAD +ADDFLG +EL L++ PRGAK+ + C + + V +SIFK KR +GWWP NE+D E ++ GK++AE LL+ EE E PVGL RNEP+ L PNRPD+SF+ F+NPLKS +Y + + ++W L+K L++ LL L LF+Y+ PGYLAK++LGA Sbjct: 1405 IDELKVYPKELE--SEFDSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDPTYGMFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHF-GPHGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNEND--EFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKFLLLFLLLLLFALFLYSLPGYLAKKILGA 1997
BLAST of Otoferlin vs. UniProt/SwissProt
Match: sp|Q2WGJ9|FR1L6_HUMAN (Fer-1-like protein 6 OS=Homo sapiens OX=9606 GN=FER1L6 PE=2 SV=2) HSP 1 Score: 698.353 bits (1801), Expect = 0.000e+0 Identity = 411/1157 (35.52%), Postives = 628/1157 (54.28%), Query Frame = 3 Query: 669 AATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVL---RSESGGLPAGAKVYSVP----------------PISDGTCG-------------------------KKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS--------EANEEEEKEVPSVNQGN---RPKIPKWCHSTTEPMLP--DTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAI--RLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY----SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIK------------GKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAI 3908 +A+ R + +H +++++QI+IT+ EARQL G NI+P++ + IG++ K + V+ TNSP+YN+Y F+F + LFD++I++ +L+ LIG F++D+ TVYN P H F +KWA+L DP DI +G KGY+K D+++MGKG+ +K PK+ + +E IE NLL+P +R A V++YKAE LP+MN+ IMA + A GDSK LVDPFV+VSFAG GRT V+KN P W+E+++F EMFP LC R+++ V+D ++ + +ATH+IDL +I NE GD GFLPTFGP+W+NLYG+PRN++ +M +E+N G GEGV++RGR+L+ I + R++ K +P DG K E FLL GAF+EA++ID +IG K PI FE+S+G GN +D A EE +P +++G +P STT P P ++ Y +L F KKPC+Y IS D R N+LEK+ + ++E + EL + +MK L FI + ++ + + +T LDK+R+ L LE M +AK + Q K L++ + E + ++K+ L+ PQ+ +PD+FIW++ + +R+A+ARI ++++LYS + + G ++ T FL+ PG+ P+GW++Q ++ +YLWLG ++ LP+GY S+ PP ++Y E+ FQLRAHM+ AR LI +D +GLSD FA++ H TTK++ +TLSP W+Q L+ + ++ + + +PP++VVE++D D + GK E+LG P V L +++Y+ PRL + I+ G ++ G+LLA FEL+QV P +G+Q + P E +T + PVP IRP L YRVE LFWGVREM++VQL+SVD+P+ IE G + S VI S K PNFS ++ LPEN L PPL I D R FGR+ L+G + I+ + +++ K G P + + + SS ++ + P D I + Sbjct: 60 SASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFH------HKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKT------SDTEEPIEKNLLIPNGFPL--ERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHS---LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFFEATMIDRKIGDK--PISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQ-QKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGK---RPAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAV--------GKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPP-------SGLQGL-------------------------------------PPVEPPDITQ----IYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYV 1137 HSP 2 Score: 555.058 bits (1429), Expect = 7.107e-163 Identity = 282/591 (47.72%), Postives = 396/591 (67.01%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD-NRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEI-EEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 ++Y LE EF F +++TF L +G+ +D+ D +R++G FKG+ IYK + + +L + + +P N PV +L+R+Y++ A +L PADP+GKSDPY++++LG I +++ YIPKQLNP+FG+ FE+ FP+ES L I + D D++ DD+IGETKIDLENR+YSKH+A+CGL +E GYN WRD PT +L KLCK+ D P + K+ + F EED E +S E LAL+V+ +W +P GC LVPEH+ETRPL++ +KPG++QG L+MW+DMFPK++ P P+DI+PR+P YELRV IWNTEDVIL D + TG+KSSDI+VKGW+KGL D Q TDVHY SL+GEGNFNWRF+F F Y+ AE ++V +++ F++++ E K+P L LQVWD + +++DDFLG LE+ L+ PR AKS + C L + + ISIF+ KR RGWWPF+ K ++ GK++AEF L++ EE E PVG R EP L PNRPD+SF FM+P K L YLI +K ++I A I+ L+ LVLFIY PG +++R++ Sbjct: 1277 LQIYDGDLE--SEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSG--QLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPFS-------KSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854
BLAST of Otoferlin vs. TrEMBL
Match: A0A1I8G049 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 1459.12 bits (3776), Expect = 0.000e+0 Identity = 715/1304 (54.83%), Postives = 926/1304 (71.01%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISID--SHGMGSDKRTLIDPQTGEIGEFNYGQTDNE-SIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTM-YQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTG-LRSNQKGKSEFLGRCFCKPTVALEE---EEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV----IKGKIPTEEPAKKVITNTSSPNQQNNLETP--------EDKIAIPAIIEGVDNPAYI 3947 MAL+LN++ ++ LD + +R++K FRD +T+ G+DS+YFG+QF+WP+GR+++ D LE+R+Y +SKYL NK+IGS+TISLQ+L+ + + +E LID+NHS +R T+ FE+ YYSPDSQI DWRQDEF+ P+ + A + D S SD ++LI + Q D S+ +GEDD S +TLGVP+ L PTLHK ED+Q+S+T+IEA+QL+GANINP IEVR+G++ K TE+QMSTNSPYYNQY FEFHMSK+ELFDQVI +R L G M ISRL GDLIGEFR+DVRTVYNA DHMF HKWA L+DPKDIL G KGYVK D+ ++GKGEQ+K + + + ND+EDIEANLLLP + KRQ AEI V+IY+AEDLP+MNTD MATIK AITGDSKPL DP+VQVSFAGH+G+TK KKNTY P+WNE IVFTEMFP LCNR+R+SVYDWDTV+NECIATH+IDL+QIMN+ ++GF+PTFGPSW+NLYGTPRNY+Y+ M+ PKEELN GLGEGVAYRGRLL+AIKT +++++ GL +GA+V S P+ D GKKE FLL+G YEA ID+EIGKK +P+ FELS+GT GNR+D NE E + + + +P WCHS + PM P EY+H+ FNEKKPCLYM +EDH+ R FIPNILEKL +F +E + EL E+RG R++ AL T ++N+E + +I+ R + KTLLD +R K +V LEKM++KAK+M Q + N++ RLKECRA++K L +L +PQ+ LPD+F+WLI D +R+AFARIPAR+IL+S EEKG +VVT+FL+KPGR GMG GW+LQ QLKMYLWLGLL+D+K ++ +P GY D FK+RRPP EI+YTEKSYF+ RA++FMARNLIGSDESGLSDAFARI++ND VVTT V+ E+LSP WD+T+I+ ++FY ++ + +PPV+VVE+FDEDQ+T L Q GKSEFLGRCFCKP V L + Y+ PRL WWEIYRGQ+NAGELLAAFELIQ+ +G + + + ++ D+ P+E +PVP IRP+L YR+E LFWGVRE+ ++Q SV+ P++T+EFG L SD+I SCK KPNF N +K +D+MLPEN YWPPLM QCED RQFGRT+L+GNHVI++V KY+ + K A K T++P ++ + D A EG DN AY+ Sbjct: 1 MALILNVRLLEGLDGKGERLLKATFRDNVQTSNAASGRDSVYFGQQFKWPVGRRIEITDVLEIRVYNFSKYLANKMIGSLTISLQQLVHESSLKLREQLIDANHSTMRATLDFEINYYSPDSQIGDWRQDEFDYPVPPMRPGAAGEDQEDNASRISFSDAQSLIKENRNMLA---LAQGDEAGSLMTGEDDASLGNAMRKTLGVPVVLDPTLHKMEDYQLSVTIIEAKQLSGANINPCIEVRVGDRVKRTEIQMSTNSPYYNQYFPFEFHMSKSELFDQVIHIRALNKGTMMISRLFSGDLIGEFRLDVRTVYNAQDHMFFHKWACLIDPKDILGGPKGYVKCDINVIGKGEQMKTQTRKSK----SNDEEDIEANLLLPSGVPI--KRQNAEISVRIYRAEDLPKMNTDFMATIKQAITGDSKPLADPYVQVSFAGHSGKTKSKKNTYDPQWNEAIVFTEMFPPLCNRVRISVYDWDTVYNECIATHFIDLNQIMNDAESGFMPTFGPSWINLYGTPRNYSYENMIHPKEELNLGLGEGVAYRGRLLMAIKTEVKTDNSGLTSGARVASTHPVPDTVAGKKEDFLLVGVIYEAGAIDAEIGKKAKPLAFELSIGTYGNRIDGNFNEAFEDDEEDTDPNRKKILPMWCHSVSHPMTPTLTQNEYYHVPFNEKKPCLYMRCNYEDHRPRMFIPNILEKLYTQFEMEIEEMQELVNREKRGVLKRLQRALQTLLDNLEKASLAIRSCRGSAGKTLLDMQRQKTIRVQLEKMKIKAKSMRAQLISSDNVSGRLKECRALVKLLRDLSVDPQHALPDVFVWLIADGQRLAFARIPARQILHSLSEEEKGKDCGKVVTLFLRKPGRKGMGQGGWSLQCQLKMYLWLGLLKDIKHYRTTVPEGYVVDTFKYRRPPSEIVYTEKSYFEFRAYIFMARNLIGSDESGLSDAFARIIINDQVVTTHVIEESLSPMWDRTMIVSPVVFYLNEVTVQDHPPVIVVEIFDEDQVTSVLGGQQTGKSEFLGRCFCKPLVTLYNGPGDTYRPPRLDWWEIYRGQLNAGELLAAFELIQL---------DGDKCLPDFVPTAD---------------------------DLRPHEIEVEEGRQPEFIPVPPAIRPNLAHYRIEILFWGVRELAKIQFQSVESPKVTMEFGGKQLQSDMIESCKAKPNFPNNIKCLDLMLPENRWYWPPLMFQCEDCRQFGRTVLVGNHVIASVLKYIRRDETEKKASNFSMASKATVTTAAPQKRKSRTMSLRKKFGLFSDSKAKLLGSEGFDNLAYL 1259 HSP 2 Score: 810.061 bits (2091), Expect = 0.000e+0 Identity = 446/752 (59.31%), Postives = 564/752 (75.00%), Query Frame = 3 Query: 4422 KDELQDIDWWSRYYVX--------------------------------XXXXXXXXXXXXXXXNLDVLKDIEVDVKSD-DDQGGLAEIPEDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXGIFAKLPFGRVXXXXXXXXXXXXXXXXXXXNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXX-HKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 KD+LQD+DWWSR+Y + + D ++ S+ ++D+LKDI+V++KS+ DD+ GL EIPE +E+ KKKKKK+ KK K K KKK + KLPF + A+ E+ D+ E + + ++ I R K+Y PLEEVK+F GF ++FP+ +G+Q+DD+E S++R+VG FKGN+ IY++ + EF V + + +LYK LP+NDP+ +LVRIYVIR DLHPADPNGKSDPYLL+RLG INEKENYIPKQLNP+FGKCFE+D KFPQESNL I VMDWD++SGDD+IGETKIDLENR++SKH+A CGL + + GYNKWRD Q P+++L KLC+++ + PKYE N+VT+ + FY EIE++ G+K QSNEPLAL+V+ NW V G LVPEH+ETRPLF EKPGI+QG +EMW+DMFPKELG PP P+DI PR+P+SYELRVIIW+TE+V L+D G+ TGE SSDIFVKGWMKGLGIDDQVTDVHYRSL+GEGNFNWRF+F FDY+KAEDKIVYK+KDSPFAIDE E KS CKLYLQVWDAD+V++DDFLGGL+LILSKIPRGAKS + C L K+ V T SIF+NKR RGWWPF GE+EDDP E ++ GK+DAE QLL+ E EA P GLGR+EP LP PNRP++SFL+ +NPLK++KYL+C K+KW LIK LII+ L A+LVLFIY++PGYLAKR++ Sbjct: 1497 KDDLQDLDWWSRFYATIDDLEDQDFRQKIKPGTALLSFAVGARMMYSKLATAQQDEDDEESNEDVDILKDIDVEIKSEADDKAGLVEIPEGDEEDDDKKKKKKKKGKKDKKDKKKKKKKPR----KLPFKKDARAEYLAEKDDELSYEVG---QQEDNSWISRIKIYQNPLEEVKDFGGFEQTFKSFPIYRGKQEDDDEPSESRVVGTFKGNICIYQISENEFRNPVAMPSQFVLYKDLPSNDPISVLVRIYVIRCIDLHPADPNGKSDPYLLIRLGGTTINEKENYIPKQLNPVFGKCFEIDAKFPQESNLQILVMDWDMLSGDDLIGETKIDLENRFFSKHRATCGLPLEYASAGYNKWRDQQPPSVILNKLCRDFKLEAPKYEPNYNRVTINGITFYEHVEIEDETGKKTQSNEPLALKVLNNWDSV-TGVALVPEHIETRPLFTPEKPGIEQGRIEMWVDMFPKELGVPPAPLDITPRKPMSYELRVIIWDTEEVKLNDTGI-TGEASSDIFVKGWMKGLGIDDQVTDVHYRSLTGEGNFNWRFVFQFDYLKAEDKIVYKVKDSPFAIDEEEKKSMCKLYLQVWDADIVSSDDFLGGLDLILSKIPRGAKSAKACDSFLLEKESGVKTFSIFRNKRCRGWWPFIGESEDDPNEKELGGKVDAELQLLTAAEAEANPAGLGRSEPQPLPPPNRPETSFLSILNPLKAIKYLVCVKYKWLLIKLLIITLLAAILVLFIYSSPGYLAKRLM 2239
BLAST of Otoferlin vs. TrEMBL
Match: A0A267FUJ1 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig021872g3 PE=4 SV=1) HSP 1 Score: 1328.54 bits (3437), Expect = 0.000e+0 Identity = 650/1266 (51.34%), Postives = 869/1266 (68.64%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISI-----DSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGD-TGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPE-EKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALE----EEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSS 3860 M L+L + ++ LD + +R +KI FRD + + VV G+DS+ ++F+WP+ R ++ D L+ RLY +SK+L NKLIG++TISLQ+LL+ ++ E LID+NHS R+++ F++ Y++P SQ DW Q++F + D+ + + + R+ +D + + G D S G+ ++LGVP+ L PTLHK ED+Q+S+TVIEA+QL+GANINP IEV +G++ + TE+QMSTNSPYYNQY +EFHMSK ELFDQVI +R + G M ISRLLPGDLIGEFR+DVR+VYNAPDH F HKWA L+DPKDIL G KGYVK D+ ++GKGEQ K PK + +DD+DIEANLLLP + KRQM E+ VKIY+AEDLPRMNTDIMAT+K A TGDSKPL+DP+VQVSFAGHTGRTK KKNTY P+WNE ++FTEMFP LCNRIR+SV+D D V +ECIATH++DL+QIMN D GFLPTFGPSWVNLYGTPR Y+Y+ MR KEELN GLGEGVAYRGRLL+A+KT L++++ L AGA+V + P+ + G +E FLL+G YEA +D EIG K +P+ FELS+GT G + NE ++ + P WCHS + P EY+H+ FNE+KPCLYM +EDH+ R F+ NILEKL +F +E + EL ERRG R+++AL +F E ++++ ++ + +TLLD +R + ++ LEKM+VK K M T ++ +RLKECRA+ + L + + + Q+ LPD+F+WL+ + +R+AFAR+PAR+IL+SA E E+G VVT+FL+KPGR G G +GW+LQ QLKMYLWLGLL+DM+ ++ +P GY FK+RRPP EI+YTE+S F+ RA++FMARNLIGSDESGLSDAFAR++VND + TT V+ E+LSP WD+TL ++ +IFY+++ + PPV+VVE+FD+D + K EFLGRCFCKP V L E Y+ PRL WWEIYRGQ+NAGELLAAFELIQ+ P G A +E + R+ P+ +E +G P+ +PVP IRP L YR+E LFWGVRE+ +VQ SV+ P++T+EFG L+SDVI SC+ KPNF N +K++D++LPEN YWPPLM QCED RQFGRT+L+GNHVIS+VTKY+ + EE K V+++T S Sbjct: 1 MTLILTVNRLEGLDGKGERQLKIRFRDSVQNSAVVNGRDSVEVNQEFKWPLARSIEIADVLDFRLYNFSKFLANKLIGTLTISLQQLLQASRLHLCERLIDANHSTTRVSLDFDIAYHTPGSQPDDWLQEDFFGVTRGESRDELDEAETRLLLQEREALEALHRSGLDETS--VNSAAMGNDDAASSTGGD-----GGAMRKSLGVPVVLDPTLHKLEDFQLSVTVIEAKQLSGANINPCIEVCVGDQVQRTEIQMSTNSPYYNQYFAYEFHMSKWELFDQVIHIRAINKGTMMISRLLPGDLIGEFRLDVRSVYNAPDHSFFHKWACLIDPKDILGGPKGYVKCDINVIGKGEQAKETPKKSKP----SDDDDIEANLLLPMGVSV--KRQMVELAVKIYRAEDLPRMNTDIMATLKHAFTGDSKPLIDPYVQVSFAGHTGRTKSKKNTYDPQWNEAVIFTEMFPPLCNRIRISVFDSDPVHSECIATHFVDLNQIMNSSDNAGFLPTFGPSWVNLYGTPRGYSYENAMRQKEELNLGLGEGVAYRGRLLMAVKTDLKTDTASLVAGARVSATQPVPENVAGMREDFLLVGIIYEAGAMDEEIGSKGKPVSFELSIGTYGYDPGGKTNEALLEDEEDTGSTVKKSAPMWCHSVSPGRAPRLTRDEYYHVPFNERKPCLYMRCCYEDHRPRLFVSNILEKLCCQFEQDIEDVQELVSRERRGVLSRLQSALQSFAEALDTAAADLRACKGTGGRTLLDMQRQRQLRLMLEKMKVKLKAMRSQLTTDSVPVRLKECRALARLLRDSLLDQQHSLPDVFVWLLCEGQRLAFARVPARQILHSATSEAERGKDCGRVVTLFLRKPGRKGAGQAGWSLQCQLKMYLWLGLLKDMRNYRGTVPEGYQATTFKYRRPPNEIVYTERSLFEFRAYLFMARNLIGSDESGLSDAFARVIVNDQIATTHVISESLSPMWDRTLAVNPVIFYFNEQTVKDQPPVVVVEIFDDDDVA--IKMPFDKPEFLGRCFCKPMVTLATSALREPYRPPRLDWWEIYRGQLNAGELLAAFELIQLDPATGQTPAFA-PSLEDLRRAPIPV-----------EEQDDGGDGDSADGGRKPD-----------WIPVPASIRPRLARYRIEILFWGVRELAKVQFQSVESPKVTVEFGGRQLVSDVINSCRAKPNFPNSIKFLDLLLPENKWYWPPLMFQCEDNRQFGRTVLVGNHVISSVTKYIKR-----EETEKTVVSDTQS 1223
BLAST of Otoferlin vs. TrEMBL
Match: A0A267GRG1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig021872g1 PE=4 SV=1) HSP 1 Score: 1321.22 bits (3418), Expect = 0.000e+0 Identity = 651/1266 (51.42%), Postives = 873/1266 (68.96%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADD-----ISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGD-TGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPE-EKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALE----EEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSS 3860 M L+L + ++ LD + +R +KI FRD + + VV G+DS+ ++F+WP+ R ++ D L+ RLY +SK+L NKLIG++TISLQ+LL+ ++ E LID+NHS R+++ F++ Y++P SQ DW Q++F + D+ + + + + +R+ +D + + G D S G+ ++LGVP+ L PTLHK ED+Q+S+TVIEA+QL+GANINP IEV +G++ + TE+QMSTNSPYYNQY +EFHMSK ELFDQVI +R + G M ISRLLPGDLIGEFR+DVR+VYNAPDH F HKWA L+DPKDIL G KGYVK D+ ++GKGEQ K PK+ K +DD+DIEANLLLP + KRQM E+ VKIY+AEDLPRMNTDIMAT+K A TGDSKPL+DP+VQVSFAGHTGRTK KKNTY P+WNE ++FTEMFP LCNRIR+SV+D D V++ECIATH++DL+QIMN D GFLPTFGPSWVNLYGTPR Y+Y+ MR KEELN GLGEGVAYRGRLL+AIKT L++++ L AGA+V + P+ + G +E FLL+G YEA +D EIG K +P+ FELS+GT G + NE ++ + P WCHS + P EY+H+ FNE+KPCLYM +EDH+ R F+ NILEKL +F +E + EL ERRG R+++AL +F E ++++ ++ + +TLLD +R + ++ LEKM+VK K M T ++ +RLKECRA+ + L + + + Q+ LPD+F+WL+ + +R+AF+R+PAR+IL+SA E E+G VVT+FL+KPGR G G +GW+LQ QLKMYLWLGLL+DM+ ++ +P GY FK+RRPP EI+YTE+S F+ RA++FMARNLIGSDESGLSDAFAR++VND + TT V+ E+LSP WD+TL ++ +IFY+++ + PPV+VVE+FD+D + K EFLGRCFCKP V L E Y+ PRL WWEIYRGQ+NAGELLAAFELIQ+ P G A +E + R+ P+ +E +G P+ +PVP IRP L YR+E LFWGVRE+ +VQ SV+ P++T+EFG L+SDVI SC+ KPNF N +K++D++LPEN YWPPLM QCED RQFGRT+L+GNHVIS+VTKY+ + EE K V+++T S Sbjct: 1 MTLILTVNRLEGLDGKGERQLKIRFRDSVQNSAVVNGRDSVEVNQEFKWPLARSIEIADVLDFRLYNFSKFLANKLIGTLTISLQQLLQASRLHLCERLIDANHSTTRVSLDFDIAYHTPGSQPDDWLQEDFFGVTRGESRDELDEAETRLLQQEREALEALQRSGLDETS--VNSAAMGNDDAASSTGGD-----GGAMRKSLGVPVVLDPTLHKLEDFQLSVTVIEAKQLSGANINPCIEVCVGDQVQRTEIQMSTNSPYYNQYFAYEFHMSKWELFDQVIHIRAINKGTMMISRLLPGDLIGEFRLDVRSVYNAPDHSFFHKWACLIDPKDILGGPKGYVKCDINVIGKGEQAKDAPKTPKKSKP-SDDDDIEANLLLPMGVSV--KRQMVELAVKIYRAEDLPRMNTDIMATLKHAFTGDSKPLIDPYVQVSFAGHTGRTKSKKNTYDPQWNEAVIFTEMFPPLCNRIRISVFDSDPVYSECIATHFVDLNQIMNSSDNAGFLPTFGPSWVNLYGTPRGYSYENAMRQKEELNLGLGEGVAYRGRLLMAIKTDLKTDTASLVAGARVSATQPVPENVAGMREDFLLVGIIYEAGAMDEEIGSKGKPVSFELSIGTYGYDPGGKTNEALLEDEEDTGSTVKKSAPMWCHSVSPGRAPRLTRDEYYHVPFNERKPCLYMRCCYEDHRPRLFVSNILEKLCCQFEQDIEDVQELVSRERRGVLSRLQSALQSFAEALDTAAADLRACKGTGGRTLLDMQRQRQLRLMLEKMKVKLKAMRSQLTTDSVPVRLKECRALARLLRDSLLDQQHSLPDVFVWLLCEGQRLAFSRVPARQILHSATSEAERGKDCGRVVTLFLRKPGRKGAGQAGWSLQCQLKMYLWLGLLKDMRNYRGTVPEGYQATTFKYRRPPNEIVYTERSLFEFRAYLFMARNLIGSDESGLSDAFARVIVNDQIATTHVISESLSPMWDRTLAVNPVIFYFNEQTVKDQPPVVVVEIFDDDDVA--IKMPFDKPEFLGRCFCKPMVTLATSALREPYRPPRLDWWEIYRGQLNAGELLAAFELIQLDPATGQTPAFA-PSLEDLRRAPIPV-----------EEQDDGGDGDSADGGRKPD-----------WIPVPASIRPRLARYRIEILFWGVRELAKVQFQSVESPKVTVEFGGRQLVSDVINSCRAKPNFPNSIKFLDLLLPENKWYWPPLMFQCEDNRQFGRTVLVGNHVISSVTKYIKR-----EETEKTVVSDTQS 1226 HSP 2 Score: 780.4 bits (2014), Expect = 0.000e+0 Identity = 423/728 (58.10%), Postives = 542/728 (74.45%), Query Frame = 3 Query: 4404 KKAKIPKDELQDIDWWSRYYVXXXXXXXXXXXXXXXX-NLDVLKDIEVDVKSD-DDQGGLAEIPEDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXGIFAKLPFGRVXXXXXXXXXXXXXXXXXXXNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 KK K+E QD+DWWSRYYV+ EDL+ + N D+L+DI+VD+KSD D+ G+ EIPE E + K KKKKKK+KKKKK KK + + LPFG + + DD + V PD ++ I R ++Y CPLE+V EF GF +TFP+ +G+Q+DD+E S++R VG FKGN+ IY++ E L+K LP+N+P+ ++VR+Y++R DLHPADPNGKSDPYL+++LGN INEKENYIPKQLNP+FGKCFE+D KFPQESNLL+ VMDWD++S DD+IGETKIDLENR +SKH+A CGL + GYNKWRD QLP+ +LA+ C+E+G +PP YE N+VTV Y A+ E++ G +SNEPLAL+ + +W + G LVPEH+ETRPLF EKPGI+QG +EMW+D+FPKELG PP +DI PRQP+SYELRVIIW+TE+V L+D G LTGE SSDIFVKGWMKGLGIDDQVTDVHYRSL+GEGNFNWRFIF FDY+KAEDKIVY++KDS FAIDE E K+ C+L LQVWDAD+V++DDFLGGLEL LSK+PRGAK + CG L+KD V T S+F NKR RGWWPF GE ++D E ++ GK+D E QLL+ E EA P GLGR EP +P PNRP+S+F+N +NPLK+L L+ ++FKW L+K LI+S ++A+L LFIY++PGY+AK+++GA Sbjct: 1412 KKLPPSKEEEQDLDWWSRYYVTNEDLNQQEDVQAESDDNDDILRDIDVDIKSDAGDREGIVEIPEGEPEDDKKKKKKKKKKKKKKKKKKR------SLRQMLPFG---IDARSQYLAEKDDEIAFEGVHPDDNSWISRLRIYQCPLEDVPEFGGFEHLFRTFPIYRGKQEDDDEPSESREVGAFKGNICIYRLKPGESHRP---KNFALHKDLPSNEPLSVMVRVYIVRCIDLHPADPNGKSDPYLIIKLGNTTINEKENYIPKQLNPVFGKCFEIDAKFPQESNLLVVVMDWDMLSEDDLIGETKIDLENRLFSKHRATCGLPLEYSCTGYNKWRDQQLPSAILARQCREFGLEPPHYEPNYNRVTVGGQTLYEHADTEDETGRIIKSNEPLALKALCSWESI-TGVPLVPEHIETRPLFTPEKPGIEQGRIEMWVDLFPKELGTPPAAVDITPRQPVSYELRVIIWDTEEVPLNDTGGLTGEASSDIFVKGWMKGLGIDDQVTDVHYRSLNGEGNFNWRFIFKFDYLKAEDKIVYRVKDSLFAIDEEEKKAMCRLNLQVWDADIVSSDDFLGGLELSLSKMPRGAKLAKACGTFLLDKDSGVKTFSLFHNKRCRGWWPFLGEADEDSNERELAGKVDVELQLLTAAEAEANPAGLGREEPQPMPPPNRPESTFMNMLNPLKALA-LMWHRFKWVLLKLLIVSLIVAILALFIYSSPGYIAKKIIGA 2125
BLAST of Otoferlin vs. TrEMBL
Match: A0A267H7D0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig001532g2 PE=4 SV=1) HSP 1 Score: 1243.41 bits (3216), Expect = 0.000e+0 Identity = 593/1010 (58.71%), Postives = 768/1010 (76.04%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISID--SHGMGSDKRTLIDPQTGEIGEFNYGQTDNE-SIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTM-YQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQK 3113 MAL+LN++ ++ LD + +R++K FRD +T+ G+DS+YFG+QF+WP+GR+++ D LE+R+Y +SKYL NK+IGS+TISLQ+L+ + + +E LID+NHS +R T+ FE+ YYSPDSQI DWRQDEF+ P+ + A + D S SD ++LI + Q D S+ +GEDD S +TLGVP+ L PTLHK ED+Q+S+T+IEA+QL+GANINP IEVR+G++ K TE+QMSTNSPYYNQY FEFHMSK+ELFDQVI +R L G M ISRL GDLIGEFR+DVRTVYNA DHMF HKWA L+DPKDIL G KGYVK D+ ++GKGEQ+K +PK+ T+K K ND+EDIEANLLLP + KRQ AEI V+IY+AEDLP+MNTD MATIK AITGDSKPL DP+VQVSFAGH+G+TK KKNTY P+WNE IVFTEMFP LCNR+R+SVYDWDTV+NECIATH+IDL+QIMN+ ++GF+PTFGPSW+NLYGTPRNY+Y+ M+ PKEELN GLGEGVAYRGRLL+AIKT +++++ GL +GA+V S P+ D GKKE FLL+G YEA ID+EIGKK +P+ FELS+GT GNR+D NE E + + + +P WCHS + PM P EY+H+ FNEKKPCLYM +EDH+ R FIPNILEKL +F +E + EL E+RG R++ AL T ++N+E + +I+ R + KTLLD +R K +V LEKM++KAK+M Q + N++ RLKECRA++K L +L +PQ+ LPD+F+WLI D +R+AFARIPAR+IL+S EEKG +VVT+FL+KPGR GMG GW+LQ QLKMYLWLGLL+D+K ++ +P GY D FK+RRPP EI+YTEKSYF+ RA++FMARNLIGSDESGLSDAFARI++ND VVTT V+ E+LSP WD+T+I+ ++FY ++ + +PPV+VVE+FDEDQ+T + Q+ Sbjct: 1 MALILNVRLLEGLDGKGERLLKATFRDNVQTSNAASGRDSVYFGQQFKWPVGRRIEITDVLEIRVYNFSKYLANKMIGSLTISLQQLVHESSLKLREQLIDANHSTMRATLDFEINYYSPDSQIGDWRQDEFDYPVPPMRPGAAGEDQEDNASRISFSDAQSLIKENRNMLA---LAQGDEAGSLMTGEDDASLGNAMRKTLGVPVVLDPTLHKMEDYQLSVTIIEAKQLSGANINPCIEVRVGDRVKRTEIQMSTNSPYYNQYFPFEFHMSKSELFDQVIHIRALNKGTMMISRLFSGDLIGEFRLDVRTVYNAQDHMFFHKWACLIDPKDILGGPKGYVKCDINVIGKGEQMKSRPKTQTRKSKSNDEEDIEANLLLPSGVPI--KRQNAEISVRIYRAEDLPKMNTDFMATIKQAITGDSKPLADPYVQVSFAGHSGKTKSKKNTYDPQWNEAIVFTEMFPPLCNRVRISVYDWDTVYNECIATHFIDLNQIMNDAESGFMPTFGPSWINLYGTPRNYSYENMIHPKEELNLGLGEGVAYRGRLLMAIKTEVKTDNSGLTSGARVASTHPVPDTVAGKKEDFLLVGVIYEAGAIDAEIGKKAKPLAFELSIGTYGNRIDGNFNEAFEDDEEDTDPNRKKILPMWCHSVSHPMTPTLTQNEYYHVPFNEKKPCLYMRCNYEDHRPRMFIPNILEKLYTQFEMEIEEMQELVNREKRGVLKRLQRALQTLLDNLEKASLAIRSCRGSAGKTLLDMQRQKTIRVQLEKMKIKAKSMRAQLISSDNVSGRLKECRALVKLLRDLSVDPQHALPDVFVWLIADGQRLAFARIPARQILHSLSEEEKGKDCGKVVTLFLRKPGRKGMGQGGWSLQCQLKMYLWLGLLKDIKHYRTTVPEGYVVDTFKYRRPPSEIVYTEKSYFEFRAYIFMARNLIGSDESGLSDAFARIIINDQVVTTHVIEESLSPMWDRTMIVSPVVFYLNEVTVQDHPPVIVVEIFDEDQVTSVLGGQQ 1005
BLAST of Otoferlin vs. TrEMBL
Match: A0A1I8H3Y7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 1197.57 bits (3097), Expect = 0.000e+0 Identity = 588/1067 (55.11%), Postives = 758/1067 (71.04%), Query Frame = 3 Query: 687 TLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXX---XXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGD-TGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPE-EKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALE----EEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSS 3860 +LGVP+ L PTLHK ED+Q+S+TVIEA+QL+GANINP IEV +G++ + TE+QMSTNSPYYNQY +EFHMSK ELFDQVI +R + G M ISRLLPGDLIGEFR+DVR+VYNAPDH F HKWA L+DPKDIL G KGYVK D+ ++GKGEQ K A KK K +DD+DIEANLLLP + KRQM E+ VKIY+AEDLPRMNTDIMAT+K A TGDSKPL+DP+VQVSFAGHTGRTK KKNTY P+WNE ++FTEMFP LCNRIR SV+D D V +ECIATH++DL+QIMN D GFLPTFGPSWVNLYGTPR Y+Y+ MR KEELN GLGEGVAYRGRLL+AIKT L++++ L AGA+V + P+ + G +E FLL+G YEA +D EIG K +P+ FELS+GT G + NE ++ + P WCHS + P EY+H+ FNE+KPCLYM +EDH+ R F+ NILEKL +F +E + EL ERRG R+++AL +F E ++++ ++ + +TLLD +R + ++ LEKM+VK K M T ++ +RLKECRA+ + L + + + Q+ LPD+F+WL+ + +R+AF+R+PAR+IL+SA E E+G VVT+FL+KPGR G G +GW+LQ QLKMYLWLGLL+DM+ ++ +P GY FK+RRPP EI+YTE+S F+ RA++FMARNLIGSDESGLSDAFAR++VND + TT V+ E+LSP WD+TL ++ +IFY+++ + PPV+VVE+FD+D + K EFLGRCFCKP V L E Y+ PRL WWEIYRGQ+NAGELLAAFELIQ+ P G A +E + R+ P+ +E +G P+ +PVP IRP L YR+E LFWGVRE+ +VQ SV+ P++T+EFG L+SDVI SC+ KPNF N +K++D++LPEN YWPPLM QCED RQFGRT+L+GNHVIS+VTKY+ + EE K V+++T S Sbjct: 1 SLGVPVVLDPTLHKLEDFQLSVTVIEAKQLSGANINPCIEVCVGDQVQRTEIQMSTNSPYYNQYFAYEFHMSKWELFDQVIHIRAINKGTMMISRLLPGDLIGEFRLDVRSVYNAPDHSFFHKWACLIDPKDILGGPKGYVKCDINVIGKGEQAKASAGDANLTPKKSKPSDDDDIEANLLLPMGV--SVKRQMVELAVKIYRAEDLPRMNTDIMATLKHAFTGDSKPLIDPYVQVSFAGHTGRTKSKKNTYDPQWNEAVIFTEMFPPLCNRIRFSVFDSDPVHSECIATHFVDLNQIMNSSDNAGFLPTFGPSWVNLYGTPRGYSYENAMRQKEELNLGLGEGVAYRGRLLMAIKTDLKTDTASLVAGARVSATQPVPENVAGMREDFLLVGIIYEAGAMDEEIGSKGKPVSFELSIGTYGYDPGGKTNEALLEDEEDTGSTVKKSAPMWCHSVSPGRAPRLTRDEYYHVPFNERKPCLYMRCCYEDHRPRLFVSNILEKLCCQFEQDIEDVQELVSRERRGVLSRLQSALQSFAEALDTAAADLRACKGTGGRTLLDMQRQRQLRLMLEKMKVKLKAMRSQLTTDSVPVRLKECRALARLLRDSLLDQQHSLPDVFVWLLCEGQRLAFSRVPARQILHSATSEAERGKDCGRVVTLFLRKPGRKGAGQAGWSLQCQLKMYLWLGLLKDMRNYRGTVPEGYQATTFKYRRPPNEIVYTERSLFEFRAYLFMARNLIGSDESGLSDAFARVIVNDQIATTHVISESLSPMWDRTLAVNPVIFYFNEQTVKDQPPVVVVEIFDDDDVA--IKMPFDKPEFLGRCFCKPMVTLATSALREPYRPPRLDWWEIYRGQLNAGELLAAFELIQLDPATGQTPAFA-PSLEDLRRAPIPV-----------EEQDDGGDGDSADGGRKPD-----------WIPVPASIRPRLARYRIEILFWGVRELAKVQFQSVESPKVTVEFGGRQLVSDVINSCRAKPNFPNSIKFLDLLLPENKWYWPPLMFQCEDNRQFGRTVLVGNHVISSVTKYIKR-----EETEKTVVSDTQS 1035 HSP 2 Score: 757.673 bits (1955), Expect = 0.000e+0 Identity = 389/668 (58.23%), Postives = 489/668 (73.20%), Query Frame = 3 Query: 4404 KKAKIPKDELQDIDWWSRYYVXXXXXXXXXXXXXXXX-NLDVLKDIEVDVKSD-DDQGGLAEIPEDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXGIFAKLPFGRVXXXXXXXXXXXXXXXXXXXNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSP 6401 KK K+E QD+DWWSRYYV+ EDL+ + N D+L+DI+VD+KSD D+ G+ EIPE E + K KKKKKK+KKKKK +K LPFG+ + + DD + V PD ++ I R ++Y CPLE+V EF GF +TFP+ +G+Q+DD+E S++R VG FKGN+ IY++ E L+K LP+N+P+ ++VR+Y++R DLHPADPNGKSDPYL+++LGN INEKENYIPKQLNP+FGKCFE+D KFPQESNLL+ VMDWD++S DD+IGETKIDLENR +SKH+A CGL + GYNKWRD QLP+ +LA+ C+E+G +PP YE N+VTV Y A+ E++ G +SNEPLAL+ + +W + G LVPEH+ETRPLF EKPGI+QG +EMW+D+FPKELG PP +DI PRQP+SYELRVIIW+TE+V L+D G LTGE SSDIFVKGWMKGLGIDDQVTDVHYRSL+GEGNFNWRFIF FDY+KAEDKIVY++KDS FAIDE E K+ C+L LQVWDAD+V++DDFLGGLEL LSK+PRGAK + CG L+KD V T S+F NKR RGWWPF GE ++D E ++ GK+D E QLL+ E EA P GLGR EP +P P Sbjct: 1221 KKLPPSKEEEQDLDWWSRYYVTNEDLNQQEDVQAESDDNDDILRDIDVDIKSDAGDREGIVEIPEGEPEDDKKKKKKKKKKKKKKKRKRSA-------HCMLPFGK---DARSQYLAEKDDEIAFEGVHPDDNSWISRLRIYQCPLEDVPEFGGFEHLFRTFPIYRGKQEDDDEPSESREVGAFKGNICIYRLKPGESHRP---KNFALHKDLPSNEPLSVMVRVYIVRCIDLHPADPNGKSDPYLIIKLGNTTINEKENYIPKQLNPVFGKCFEIDAKFPQESNLLVVVMDWDMLSEDDLIGETKIDLENRLFSKHRATCGLPLEYSCTGYNKWRDQQLPSAILARQCREFGLEPPHYEPNYNRVTVGGQTLYEHADTEDETGRIIKSNEPLALKALCSWESI-TGVPLVPEHIETRPLFTPEKPGIEQGRIEMWVDLFPKELGTPPAAVDITPRQPVSYELRVIIWDTEEVPLNDTGGLTGEASSDIFVKGWMKGLGIDDQVTDVHYRSLNGEGNFNWRFIFKFDYLKAEDKIVYRVKDSLFAIDEEEKKAMCRLNLQVWDADIVSSDDFLGGLELSLSKMPRGAKLAKACGTFLLDKDSGVKTFSLFHNKRCRGWWPFLGEADEDSNERELAGKVDVELQLLTAAEAEANPAGLGREEPQPMPPP 1874
BLAST of Otoferlin vs. Ensembl Cavefish
Match: otofa (otoferlin a [Source:NCBI gene;Acc:557476]) HSP 1 Score: 858.21 bits (2216), Expect = 0.000e+0 Identity = 483/1291 (37.41%), Postives = 736/1291 (57.01%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISI-DSHG-----MGSDKRTLIDPQTGEIGEFNYGQTDNESIESG----EDDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVYSVPP--ISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS--------------------------EANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKFRR----PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYV 3800 MALV+ LK V L + DRI K++FR ++V+ +D F E F+WP+ K+D + LE+ +Y YSK N+LIG+ + LQK++E+ + + LID N++ I+ ++S E+ Y D + W EF + +R++ + S+ SH + +LI + D +++ G D S A+ A T V + + P+ + D+QIS+TVIEARQL G N++P++ V IGE K T ++ STN PYYN+Y F+FH+ +FD++++L + N+ L G L+G F++DV TVY+ P+H F HKWAML DP DI +G KGY+K D+ ++GKG+ +K K+ + D++DIE NLLLP+ + + +RQ A VKIY+AE LP+MNT IMA +K A G+++ LVDP+VQV FAG G+T V+K++Y P WNE+I+FTEMFP LC R++V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ RNYT +M ++LN GLGEGV++R RLLI++ +L + S + + +V P IS+ GK E F L G+F EA+++D +IG K PI FE+++G GN+LD + + +EE E + G+ + S+T PM P D+ YFHL + EKKPC+Y+ S+ +D + R + NI++K+ ++ + + E+ E+ R++ L+ + ++ + +T LD+ER+K +E M +AKT+ + + +LK +++L L PQ+ +PD+FIW++ + KR+A+ARIP ++IL+S + EE G +V VFL+ PG+ G GP+GWT+Q +L+MYLWLGL + K F GLP G+ N K PP+ + Y K FQLRAHM+ AR+L +D SGLSD FAR+ + H T+V+ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK+E++GR F KP + +E Y PR L +++IYRG AGELLAAFEL+Q+ P R E L ++G + D P ++PVP IRP L YR+E LFWG+R+++R+ L VD+PR+ IE + S + + K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G+H ++++ K++ Sbjct: 1 MALVVYLKTVTELRGKGDRIAKVSFRGLSFYSRVLENCEDEARFEEAFRWPVASKVDGNEMLEIHIYNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTSISIEIRYQPMDGSVRVWSDGEFLDVPEEREMFQFETESLLSSHSHICSVCATSVFSLIFSFLDDAAILEMEDLDRKAMRLGGGLDPDTISLASVTAVTTNVSNKRSKPDIKMEPSAGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKLSVIHSKNL----LRSGTLVGTFKLDVGTVYSQPEHQFYHKWAMLSDPDDITAGCKGYIKCDIAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPS--ERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVQVQFAGQKGKTSVQKSSYEPIWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANDGDKGFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISVAVEILDTTSPEIMSSTEVQMEPVSNISESATGKLEEFFLFGSFLEATMVDRKIGDK--PINFEVTIGNYGNQLDGVSKPVSGKKKKREGGGESDEEESELIQNSSDEETE----DDGDLVSV-----SSTPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEIIKTEKAYPERRLRGVLEELSTGCSRFVTLANKDQNQAGRTKLDRERLKSCMREMESMGQQAKTIRSQVKRNTVRDKLKLALNFLQRLRFLADEPQHSIPDVFIWMMSNNKRIAYARIPTKDILFSIVDEEMGKDCGKVKAVFLRLPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLSGLPNGFEENKAVKGTGLQAVPPISLTYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEATELRDDPPIIVIEIYDQDTV--------GKAEYIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCTAGELLAAFELLQIGP---------AGRTE------------------------LPPIDGPTDVDRGP------------ILPVPLGIRPVLSRYRIEVLFWGLRDLKRINLAQVDRPRVDIECAGKGIQSALNQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTSLRKFI 1213 HSP 2 Score: 633.639 bits (1633), Expect = 0.000e+0 Identity = 320/584 (54.79%), Postives = 419/584 (71.75%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGRQ---DDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 EF+ F ++ TF L +G+ DD D+RIVG FKG+L +YK+ + + +++S+P+NDP+ +LVR+YVIRA DLHPAD NGK+DPY++++LG I +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENRYYSKH+A CG+ + HGYN WRD Q PT +LAKLCKE D P Y KV VA F +IE++NG KKQ+ E LAL +K+W ++P GC L+PEH+ETRPL N +KPGI+QG LEMW+DMFP ++ +P IDI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L +QVWDAD +ADDFLG +EL L++ PRGAK+ + C + + + + TISIFK KR +GWWPF +E+D +L++ GK++AE L++ EE E PVGLGRNEP+ L PNRPD+S + FMNPLKSL+Y I + ++W ++K L + LL LL LF+Y+ PGYL K++LGA Sbjct: 1293 EFDHFEDWLHTFNLYRGKAIDDDDQNIVDDDRIVGRFKGSLCMYKLPLSDEITRDVGFDPNMGMFQSIPHNDPINVLVRVYVIRATDLHPADINGKADPYVVIKLGKSEIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVSVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSLHGYNVWRDPQKPTQILAKLCKEGKLDGPHY-GPGGKVKVANRIFLGPTDIEDENGLKKQTEEHLALTALKHWEEIPRVGCKLIPEHVETRPLLNPDKPGIEQGRLEMWVDMFPMDVPSPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESLFSWDETEYKIPARLTMQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIDMVLNEQELPTISIFKQKRVKGWWPFVARDEND--DLELTGKVEAELHLMTAEEAEKSPVGLGRNEPDPLEKPNRPDTSLMWFMNPLKSLRYFIWHNYRWLILKTLGLMLLLLLLGLFLYSIPGYLVKKLLGA 1873
BLAST of Otoferlin vs. Ensembl Cavefish
Match: otofb (otoferlin b [Source:ZFIN;Acc:ZDB-GENE-110406-5]) HSP 1 Score: 779.63 bits (2012), Expect = 0.000e+0 Identity = 427/1102 (38.75%), Postives = 637/1102 (57.80%), Query Frame = 3 Query: 654 DDESFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEA--------------NEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKF----RRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSS 3860 D S A+ A T V + + P + D+QIS+TVIE RQL G N++P++ V IG++ K T ++ STN PYYN+Y F+FH+ +FD++++L + N+ L G ++G F+MDV TVY+ DH F HKWA+L DP DI +G KGYVK D+ ++ KG+ +K K+ + D++DIE NLLLP+ + +RQ A +KIY+AE LP+MNT IMA +K A G++K L+DP+VQV FAG G+T V+K+ Y P WNE+IVFTE FP LC R++V + D D V + + TH+IDL +I N+GD GFLPT GP+WVN+YG+ R+YT +M ++LN GLGEGV++R RLL+++ +L + S + +V VP ISD GK E F L GAF EA++ID +IG K PI FE+++G G+ +D +EE E S ++ STT PM P D+ YFHL + E+KPC+Y+ S+ +D + R + NI++ + ++ + + E+ E+ R++ L+ + L ++ S KT LD+ER+K LE M +AKTM K + + K+ + ++KL L PQ+ +PDI+IW+I + KR+A+AR+P+++ILYS + EE G +V T+F + PG+ G GP+GWT+Q + +MYLWLGL R K F GLP G+ N K PP+ +IYT K FQLR H++ AR+L +D +GLSD FAR+ + H T+++ ETL P WDQ L+ D++ Y + +PP++V+E++D+D + GK++F+GR F KP + +E Y PR L ++++YRG AGE+LAAFEL+Q+ P D+ P +G T G ++PVP IRP L YR+E LFWG+R+++RV L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G+H ++++ K++ + P+ K + N S+ Sbjct: 137 DTISLASVTAVTTNVSNKRSKPDIKIEPGAGRPMDFQISVTVIECRQLVGLNMDPVVCVEIGDEKKYTSMKESTNCPYYNEYFVFDFHLPPDVIFDKILKLSVIHSKNL----LRSGTVVGTFKMDVGTVYSQADHQFYHKWAILCDPDDITAGCKGYVKCDIAVVAKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGVPA--ERQWARFYLKIYRAEGLPKMNTSIMANVKKAFIGENKDLIDPYVQVQFAGQKGKTSVQKSCYEPIWNEQIVFTEQFPPLCKRMKVQIRDSDKVNDVALGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRSYT---LMDEYQDLNEGLGEGVSFRARLLVSLAVEILDTSSPEVMCSTEVQVEGVPNISDNAAGKIEEFFLFGAFLEATMIDRKIGDK--PINFEVTIGNYGSEVDDTPTKPKSKKSKKGDGDDEESELIQGSSDEEVTDDGELVSVSTTPPMKPVITDRNYFHLPYFERKPCIYIKSWWQDQRRRLYNANIIDNIADKLEEGLNDVQEIFKTEKAFPERRLRGVLEDLSHGCSNFLELANKDQNQSGKTKLDRERLKSCMRELENMSQQAKTMRTQVKKKTVKDKFKQAQIFLQKLRFLADEPQHSVPDIYIWMISNGKRIAYARVPSKDILYSNVEEETGKDCGKVKTIFFKLPGKKGFGPAGWTVQAKTEMYLWLGLNRQRKDFLSGLPNGFEENKAVKGPGMQSAPPISLIYTMKQIFQLRVHLYQARSLFAADSTGLSDPFARVFFSTHSQVTEILNETLCPTWDQLLVFDNVELYGEACELRDDPPIIVIEIYDQDTV--------GKADFMGRTFAKPITKMSDEHYGPPRFPPQLEYYQVYRGNCTAGEMLAAFELLQIGPGG--------------------------------------------KADLPPIDGPTDMDRGP-ILPVPIGIRPVLSKYRIEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGIQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTSLRKFIYR-------PSDKSVNNWST 1162 HSP 2 Score: 634.024 bits (1634), Expect = 0.000e+0 Identity = 311/584 (53.25%), Postives = 426/584 (72.95%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGRQDDDEE---SSDNRIVGNFKGNLNIYK--XXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 EFE F ++ TF L +G+ DD+E S ++R++G FKG+L +YK + D+ + +++++P+NDP+ ILVR+YVIRA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FGK F+++ FP +S+L + V DWDLV DD+IGETKIDLENRYY+KH+A CG+ + HGYN WRD PT +LAKLCK+ DPP+Y +V VA + EIE++NG KKQ++E LAL V+ +W +P GC LVPEH+ETRPL N +KPGI+QG +EMW+DMFPK++ AP +DI+PR+P +ELRVIIWNT++V+L D + TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRFI+ FDY+ AE+KIV K+S F+ DETE K P +L +QVWDAD +ADDFLG +EL L++ PRGAK+ + C + + + + ++IFK KR +GWWPF +E+D EL++ GK++AE L++ EE E PVG GRNEP L PNRPD++ L F+ PLK++K+L+CN +KW +IK +++ LLA+L LF+Y+ PGY+ K++LGA Sbjct: 1240 EFEHFEDWLHTFNLYRGKSGDDDEQNASDEDRLIGKFKGSLCMYKVPMTDDMGREMGIDSNMGMFQNIPHNDPINILVRVYVIRATDLHPADINGKADPYIAIKLGKTEIKDKENYISKQLNPVFGKSFDIEATFPMDSSLTVSVYDWDLVGTDDLIGETKIDLENRYYTKHRATCGITASYAIHGYNVWRDPMKPTHILAKLCKDGKLDPPQY-GPGGRVKVANRVYTGPTEIEDENGLKKQTDEHLALAVLNHWEDMPRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPKDMPAPGPALDISPRKPKKFELRVIIWNTDEVVLEDDDIFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLMAEEKIVISKKESMFSWDETEYKIPARLNIQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTIDMVLNEQEMPMVNIFKQKRIKGWWPFVARDEND--ELEITGKVEAELHLMTGEEAEKSPVGEGRNEPEPLEKPNRPDTTLLWFLMPLKAIKHLVCNSYKWLIIKIVVVLLLLAMLGLFLYSMPGYMVKKLLGA 1820
BLAST of Otoferlin vs. Ensembl Cavefish
Match: fer1l6 (fer-1 like family member 6 [Source:ZFIN;Acc:ZDB-GENE-070912-312]) HSP 1 Score: 620.157 bits (1598), Expect = 0.000e+0 Identity = 374/1066 (35.08%), Postives = 559/1066 (52.44%), Query Frame = 3 Query: 744 ISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNE--GDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGK---KEP----------------------------FLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEA----NEEEEKEVPSVNQGNRPKIPKW-------CHSTTEPMLPDTN--DQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIR--LKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR---PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNV 3788 ISI + EARQL G NI+P + + IG++ K + V+ TN+P+YN+Y F+F + FD+VI+L + S+++ IG F++DV TVYN P H F +KWA L+DP DI +G KG++K D+ + GKG+ S + + +E IE N L+P+ + R A VK+Y+AE LPRMN+ IMA + A D+ L+DP+V VSF GRT +K+T P WNE++VF EMFP LC R+++ V D ++ + I THYIDL +I N+ GD GFLPTFGP+W+N+YG+ RN T ++ +E+N G+GEGV+YRGRL I + + + GG + + P D GK K+P F+L GA +EA++ID IG K PI FE ++G GN +D A + E+ Q P C STT P P T ++ Y++L + +KPC+++ ED R N+L+++ F + + FI ++E + C+ T+LDK+R+ L K LE M A T+ + K L I+ L+E R + +K+ L+ PQ+ LPDIF+W++ + KR+A+ARIPAR +LYS EKG ++ T+FL+ PG+ G + W +Q ++ +YLWLG + + LP G+ P ++Y + FQLRAHM+ AR LI +D +GLSD FAR+ H T ++ +TL+P W+Q L++D + + + PP++ +E++D+D + GK E+LG P V L EE Y +P L + ++ G ++ G++L AFELI+V P G + P GS + PVP IRP L YR+E LFWG+RE+++VQL++VD+P++ IE + S VI S K PNFS + ++ LPE+ PPL I D R FGR+ L+GNHVI+N+ Sbjct: 38 ISINITEARQLVGENIDPSVVIEIGDEKKQSSVKEGTNAPFYNEYFVFDFFAHQEIFFDKVIKLSVMH------SKIMKSYCIGTFKIDVGTVYNQPGHQFTNKWAALIDPNDISTGVKGHLKCDICVTGKGD------VSPRSQKFSDAEEQIEKNPLVPEGFPS--MRPWARYYVKVYRAEGLPRMNSSIMANVTKAFVSDNTALIDPYVVVSFFSQVGRTSTQKSTADPVWNEQVVFKEMFPPLCRRLKIQVLDEGSMNDVAIGTHYIDLCRISNDQDGDKGFLPTFGPAWINIYGSARNST---LVDDNQEMNEGIGEGVSYRGRLYIQLAVEILT--GGAESKSMFSLKLPSKDAKGGKTAGKDPKAGTGGADTSFIVGNLVFVKVSEENMENFILFGAMFEATMIDRRIGDK--PISFEFTIGNCGNFIDGAAPPAAKKRGERGFDHPGQEGAMTTPLLEGQAALSCKSTTRPEKPHTGHGNRVYYYLPISTQKPCIHVQCSWEDRTYRLHHSNMLDRIAFLFVSTAYYCGQ------------------EFIASVEKKVKD-NCL------TMLDKKRLTLCKQELESMIEVAGTITEPKRKV-LTIKEMLQESRKLTQKIRFLVEEPQHTLPDIFVWMLSNNKRLAYARIPARNLLYSENVVEKGKDCGKISTLFLKPPGKRG---ATWAVQAKVDVYLWLGKCTESSNMLKNLPEGFEIHGVSSEESGGAPEIVLYKDHHEFQLRAHMYQARGLIAADNTGLSDPFARVSFQSHTHVTAIINQTLTPTWNQMLMMDKLSLHGMLTELAQEPPLITIEVYDDDAL--------GKPEYLGSTVAVPVVKLAEEPYTAPSLHYSPLFCGSLSGGDILGAFELIEV-PKSGKH---------SLPPYDDPEGS---------------------------------------IYPVPSYIRPVLRKYRIEVLFWGLRELKKVQLLTVDRPQVFIECAGKGVSSSVIQSYKSNPNFSMIVDAFEVELPEDEYLHPPLTITVVDWRAFGRSTLVGNHVINNL 996 HSP 2 Score: 541.962 bits (1395), Expect = 3.632e-160 Identity = 275/591 (46.53%), Postives = 394/591 (66.67%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 K+Y LE EF F +++TF L +G+ +++E SS R VGNFKG +YK+ D E VD + + +P N V +L+R+Y++ A++LHPADP+GK+DPY++L+LG VI +++NYIPKQLNP+FG+ FE+ FP+ES L I + D+D++ GDD+IGET+IDLENR+YS+H+A+CG+ + GYN WRD PT +L KLCK+ D P++ ++T+ E Y + D + +S E LAL+V+ W ++P GC LVPEH+ETR L+ +KPG+ QG ++MW+D+FP ++ P P+DI+PR+P YELR+IIWNTEDVIL D +TG++SSDI+VKGW+KGL D Q TDVHY SL+GEGNFNWRF+F F Y+ AE +V +++ F++D+TE K P L +QVWD + +++DDFLG +EL L PRGAK+ + C + L + S ISIF+ KR +GWWPF K ++ GK++AEF L++ EE E PVG R EP L PNRPD++F F+NP K +LI +K ++I AL++ L L L Y PG L+ +++ Sbjct: 1147 LKIYDKELE--AEFGPFDDWVKTFELYRGKANEEESSSAERFVGNFKGRFCLYKLPDSEEYDCVDSGDYKINQGIPPNTAVNVLIRVYIVSASNLHPADPDGKADPYIVLKLGKTVIKDRDNYIPKQLNPVFGRSFEIQASFPKESLLKILIYDYDVIGGDDLIGETQIDLENRFYSRHRAMCGIPSEYAIDGYNAWRDCIKPTDLLIKLCKDNRLDSPRFTP--GRITIGE-KVYTGKTVFADEDQMVESYEHLALKVLHRWEEMPGVGCKLVPEHIETRALYIKDKPGLDQGQVQMWVDIFPMDMPHPGPPVDISPRKPKGYELRIIIWNTEDVILEDTNFITGQQSSDIYVKGWLKGLEDDGQETDVHYNSLTGEGNFNWRFVFPFHYLPAEKLVVVSKRENIFSLDKTEQKLPAVLVMQVWDFERLSSDDFLGSVELDLHGFPRGAKTAKDCKMEMLKE--SNDNISIFQQKRSKGWWPFI-------KSEELTGKVEAEFHLVTAEEAEKNPVGRARKEPEPLEKPNRPDTTFSWFVNPFKCFFHLIWKNYKKYIIIALLLLILALFLALLFYTLPGALSNKIVSG 1723
BLAST of Otoferlin vs. Ensembl Cavefish
Match: fer1l4 (fer-1 like family member 4 [Source:ZFIN;Acc:ZDB-GENE-130530-815]) HSP 1 Score: 504.982 bits (1299), Expect = 1.652e-146 Identity = 328/1058 (31.00%), Postives = 523/1058 (49.43%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGM---GSDKRTLIDPQTGEIGE----------FNYGQTDNESIESGEDDESFAATNARTLGVPLALH----PTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMA--ISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRS------------------------------------ESGGLPAGA-----------------KVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS---------------------EANEEEEKEVPSVNQGNRPKIPKWCHSTTEP--MLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLG----YSNDCFKF----RRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVV 2960 M++ + LK + NL + DR ++++FRDF TK+++ ++ F E F+WP K+ + L + +Y S+ +N+L+G + +SLQ ++ ++ +E L DSN+S+ I V ++ Y+ +W ++F + DR D + I + G G+ + +D +G + D + D E + T L AL K + +Q+++ VIEA+ L G NINP + + +G + K T Q STN P+YN+ FEF ++ LFD+VI + + +A ++R IG F++D+ TVY PDH F KWA + DPKD SG KGYVK L++M KG+ + + +EDIE NLLLP+ + +R A+ +KIY+AEDLP MN + + + GD K +DP+VQV+FAG G T V NT PEWNE+I F E FP L RI+V + D + + +ATH++DL QI N GF PTFGPSWVNLYG+P+N T + ++LN GL +G+ YRGR+ +++ + S ES G A + +V + P+ + G+KE FLL +F+E ++ID IG K + FELS+G G D E+++E E+E P+ ++ S T P P D + +S +KPC+Y+ +Y EDH R N L K+ + ++ + L R R+ L F+ + +S+ R P LDK R K + + +A + + T+ + +L + R I+K+++ L PQ+ LPD+F+W++ KR+A+ARIPA +L+S + EE+G +V T++++ PG GP G + +L++Y+WLG+ + K LP Y F PP ++ + YFQLRAH++ AR +I +D++GLSD F +++ + T+V Sbjct: 1 MSITVYLKTIYNLPGKYDRKVELSFRDFTHKTKILQCENVAIFKENFRWPHYGKIQKDEVLTISVYNSSRMFSNRLLGKLVVSLQHVVTAGRLVLREPLTDSNYSLTDIYVELDVRYHPLQGAAGEWSGEDFTK-VEDR---DESGLVIKNTGFLEPGNLRPQQLDRDARMLGRSLMKIDNEDGEDDDDDDYDDDYDFSDLEISSMTFTPILSRCRALSKHELAAAPKVKSFQVNVNVIEAQNLVGVNINPAVYITVGHEKKRTATQKSTNCPFYNENFMFEFQETQDVLFDKVIEISVVHKKTLAFLMTR------IGTFKIDISTVYQQPDHRFYQKWAPITDPKDTRSGVKGYVKCTLSVMMKGDSMNMASLPPAT----SQNEDIERNLLLPK--RMAAERPWAKFLLKIYRAEDLPSMNAGFLGSFS-KMMGDKKVFIDPYVQVTFAGQQGETSVVSNTNAPEWNEQISFIEQFPPLARRIKVQILDDSNMGDVAVATHFLDLQQISNPNRNGFNPTFGPSWVNLYGSPQNSTLRDI---HQDLNEGLSDGIFYRGRVQLSLSVEIYSSPTTAVIENKSSLSIKSPLSKLTFKRKSRKSREKSKESAGAQAASGPAEESEASEVPEAVTVEVEEIHPLPENFVGEKEEFLLFASFFEVTMIDPSIGSKF--VTFELSIGNYGKTADVVVKSKKSGSREDLSEDRQGLLESDDELEREEPAAGPLDK--------SVTAPRRAQPTEYDGSFSCISLLREKPCIYVWNYFEDHTFRYHNCNWLSKMADRLEYGIDEVEMLLKRPRSNAKERLMEVLLEFVSTCKQYSSSLDRKRQARPNP-LDKHRSTFIKRNIIILAKQALRVRRRVTRRTVRDKLADVRRILKRIHFLTKEPQSTLPDVFLWMMSGGKRVAYARIPAHTVLFSLVEEERGKDCGKVSTIYMKTPG----GPLG-EIFAKLEVYMWLGVTKYSKNCVTSLPAEFRPVYEGATFGTPLPPNMPPTKLAVEDSRYFQLRAHIYQARGIIAADDNGLSDPFTKVVFSTQCQVTQVT 1022 HSP 2 Score: 488.034 bits (1255), Expect = 6.512e-141 Identity = 267/615 (43.41%), Postives = 385/615 (62.60%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQD--DDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYE----ALVNKV------TVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVP----NGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTG-ENEDD-----------------------------PKELD----------VNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFK 6479 I K+Y LE EF F ++ TFP+ KG+ + D+++ +RI+G +KG+ IY + EE E D+ + + +P N P+++L R+YV++A +L PADPNGK+DPY+++++G + ++ KE YIPKQL+P+FG+ FEL V FP E+ L I + D DLV DD+IGET+IDLENR+YS+H+A CGL ++ GYNKWRD + P+ +LA LC++ G P+Y ++NK+ E + + EED E +E AL V++ W+++ C LVPEH+E R L N EKPG+ QG L MWIDMFP ++ PP ++I PR P+SYELRVIIWNT+DV+L D TGE SSDI+VKGW+KGL + Q TDVH+ SL+GEGNFNWRF+F+FDY+ E +IVYK K+S F+++E+E + L LQVWD D + ++DFLG +EL L+ + R AKS + C + ++ KD + SIF++KR +GWWP ++++D P++L + GK++AEFQL++ EE E PVG R EP L PNRP +SF F+NP+K+ + I K+K Sbjct: 1253 ISTLKLYKSELE--NEFSQFMDWLHTFPIYKGKANLEDEDDDDSDRIMGKYKGSFLIYPISSEEQEEEEDID-FQITRGIPKNSPIKVLTRVYVVKATNLAPADPNGKADPYVVVKIGQQQLDSKERYIPKQLHPVFGEVFELTVSFPLETELNIIIFDHDLVGSDDMIGETRIDLENRFYSRHRAGCGLALYYDKDGYNKWRDSRKPSAILADLCRKNGIPSPEYRDTEVKVLNKIFKIPNEAFPEELLKKNKKTEEDYAE---MDEHRALSVLQRWAEMREFTVGACPLVPEHVEVRSLLNPEKPGLPQGYLHMWIDMFPVDVPPPPP-VNIKPRLPVSYELRVIIWNTDDVVLDDVNPFTGEPSSDIYVKGWIKGLDDEKQETDVHFNSLTGEGNFNWRFVFHFDYLPTEKEIVYKKKESIFSLEESEFRQHAVLVLQVWDYDRIGSNDFLGSIELRLNDMVRAAKSSELCSV-KMAKDKASPRFSIFRSKRMKGWWPLIKLKSQEDIEREEREREMEKKNKKKKKKKQSKRGKMKPEDLQFVDSTGNTFLLMGKVEAEFQLVTAEEAEKNPVGKARKEPEPLDKPNRPKTSFNWFVNPMKTFVFFIWKKYK 1859 HSP 3 Score: 65.4698 bits (158), Expect = 8.210e-10 Identity = 32/89 (35.96%), Postives = 54/89 (60.67%), Query Frame = 3 Query: 3417 DVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIM 3683 DV P E + AE +++P + +RP L +R+E L+WG+R+++RV L V+KP++ +E + S I S K PNF +K+ D++ Sbjct: 1043 DVDPREPEYLEAEKCYIIP--EGVRPVLKKFRIEVLYWGLRDLKRVNLFEVEKPQVRMECSGQLIESGEIESYKQDPNFKEVVKHFDVV 1129
BLAST of Otoferlin vs. Ensembl Cavefish
Match: myof (myoferlin [Source:ZFIN;Acc:ZDB-GENE-040426-1138]) HSP 1 Score: 436.417 bits (1121), Expect = 6.704e-124 Identity = 235/574 (40.94%), Postives = 345/574 (60.10%), Query Frame = 3 Query: 4806 ERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVA-----FYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSV-------STISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPS---PNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 + KV+ LE V E++G F TF L +G+ +DDE+ D +VG FKG+ +Y + D+ ++ LP++ P + +VRIYV+R DL P D NG DPY+ + LG K++++++NYIP LNP+FG+ FE+ PQ+ +L I V D+DL++ D+ +GET IDLENR S+ + CGL Q + G N+WRD P+ +L + + G PP+ E N + F A+ E+ + G + E ++L V++ L+PEH+ETR L+++ +P + QG L+MW+D+FPK LG P P DI+PR+ Y LRVI+WNT +VIL D +TGE+ SDI+VKGWM G D Q TDVHYRSL G+GNFNWRFI+ FDY+ AE + K+ +++D+TE K P +L +Q+WD D + DD+LG +EL L + AK P+ C L L + + S+ S+F K RGWWP E +D KEL GK++ +++ ++E E P G GR EPN P PNRP++SF F NP K++K+++ +FKW Sbjct: 1364 DTLKVFENELENVTEYKGLTDFCNTFKLYRGKTEDDED--DPTVVGEFKGSFKVYPLSDDPAIPSPPRQ----FRELPDSGPQECVVRIYVVRGIDLQPKDNNGLCDPYIKISLGKKIVDDRDNYIPNTLNPVFGRMFEVSCFLPQDKDLKISVYDFDLLTHDEKVGETVIDLENRLLSRFGSYCGLPQTYCTSGLNQWRDQLKPSQILQNVARLKGVSPPRSEDNGNTLAFNGQEYRLSDFEANKELHQHLGP---ATERISLHVLRTQG-------LIPEHVETRTLYSTFQPTLSQGCLQMWVDVFPKSLGLPGPPFDISPRKAKKYVLRVIVWNTTNVIL-DETSITGERMSDIYVKGWMPGKEEDKQKTDVHYRSLDGDGNFNWRFIYEFDYLPAEQLCLVSKKEHFWSLDKTEFKIPPQLIIQIWDNDKFSLDDYLGTVELDLHHLISPAKMPEKCNLKMLEQAKASKSPLKFDSSKSLFAQKSVRGWWPCYIE-KDGKKEL--GGKVEMTLEIVHEKEAEERPAGKGREEPNMNPKLNPPNRPETSFFWFTNPCKTMKFIVWRRFKW 1917 HSP 2 Score: 293.123 bits (749), Expect = 4.155e-79 Identity = 206/693 (29.73%), Postives = 341/693 (49.21%), Query Frame = 3 Query: 738 WQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAI--TGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVF-NECIATHYIDLSQIMNEG----------DTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTC------GKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEF-SNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEK-GVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTF 2753 ++I + VIE RQL G NI P+++V + +T T ++ N+P++N+ + F + + +IR + + + I + ++D+ +Y+ P H + KW +L DP D GAKGY+KV I+G G+ K +D D +D+E+NLLLP G + + +K+++AED+P+M+ I ++K A TGD K LVDPF++ FAG TK+ ++ PEWN+ + FP++C RI+++VYDWD + N+ + T Y++L++I + G D GFLP FGPS++NLYG+PR +T + P E+LN G GEG AYRGR+LI + T L G V IS+ ++ + L F+ A++I E G +PI FE+S+G GN+LDS K STT+ + Y++L + + KP + ++S+ ED R NI+ + N N E+ + + + LR+ + + ++ +C + + + L + E T L + + C I + P PQN +PD+ IW+++ KR+A++R+PA ++LYS + E+ G + T+ LQ P G L Q+++ +WLGL + F Sbjct: 138 FKIRVRVIEGRQLPGNNIKPVVKVNVCGETHRTRIKRG-NNPFFNEVISF-YTIFLIPGLMYLIRNYAVIVNKVKIYIFICFTSFIFPQIDIGYIYDEPAHCVMRKWLLLNDPDDSSCGAKGYLKVSAFIVGTGDD-----PPVEKTDRDTDSDDVESNLLLP----AGIALRWVTLQLKVFRAEDIPQMDDSISQSLKAAFGGTGDKKNLVDPFLEAWFAGKKICTKIIESNANPEWNQLVNLHVKFPSMCERIKLTVYDWDRLTRNDAVGTTYLNLTKIASSGGEVEAETGEPDVGFLPAFGPSYINLYGSPREFT--GLPDPYEDLNFGKGEGAAYRGRVLIELSTKLD--------GKADTDVEAISNDDILVAQKYQRRRKYCLCAVFHSATMI-LEPG---EPIQFEVSIGNYGNKLDSTC--------------------KPLASTTQYSCAVFDGNHYYYLPWADTKPVVAIMSFWEDISHRLDAVNIILNIANRLECNITELKTAV---QAKAPDLRLAEIWQKLVSQVLEDIS--RCFYFPT----IHHTNLFLLNILNE-------------TALKLFLYVSYCIFCITWTLHMFPQPQNSMPDVIIWMLRGEKRVAYSRVPAHQVLYSVLGEQACGQYCGKTQTIVLQYPMDKNKGSK---LPAQVRVNMWLGLSTHEQKF 760 HSP 3 Score: 147.132 bits (370), Expect = 1.510e-34 Identity = 92/331 (27.79%), Postives = 152/331 (45.92%), Query Frame = 3 Query: 2805 PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKY 3797 P + ++ + + LR +++ ARNL+ D+ SD + + TT+++ +L+P WDQTLI + + Y I +PP +V+E+FD DQ+ GK E LGR C P V L+ P+L W + AGE+L + ELI L N G+ + + P + G + VP+ +RP + +E L WG+R M+ QL V P + +E G + S VI + K PNFS + + ++LP+ +Y PP++++ D R FGR ++G I+++ +Y Sbjct: 1031 PNVSCVFDQGYEYHLRVYVYQARNLMALDKDSFSDPYVHVSFLHMSQTTEIIKASLNPMWDQTLIFNRVEIYGDPQTIARDPPQVVLEIFDSDQV--------GKDELLGRSTCPPLVKLDPGMDTPPKLLWRPVIHKGTPAGEVLVSAELI------------------------------------------LRNKTGETDLPLVPPK------RGDELYMVPQGVRPVVQLTAIEILAWGLRNMKMYQLAPVSSPSLVVECGGERVQSAVIKNIKKSPNFSGNVLQLKVLLPKEEMYTPPIVLKVIDHRPFGRKPVVGQCTINSLEEY 1305
BLAST of Otoferlin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008905.1 (pep scaffold:Pmarinus_7.0:GL477019:1719:83156:1 gene:ENSPMAG00000008043.1 transcript:ENSPMAT00000008905.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 759.599 bits (1960), Expect = 0.000e+0 Identity = 429/1083 (39.61%), Postives = 625/1083 (57.71%), Query Frame = 3 Query: 714 PTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAK--VYSVPPISDGTC-GKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLD--SEAN-------------------------EEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVS---------PKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKE--CRAIIKKLNELIPNPQNGLPDIFIW-LIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRR-PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIP 3818 PT K + +Q+S+ +IEARQL G N++P++ V +GE+ K T + STN PYYN+Y F+FH +FD++I+L + N+ S G L+G F++DV TVY+ PDH F HKWA+L DP DI +G KGYV D+ ++GKG+ +K KS DND + IE NLLLP+ I RQ A V+IYKAE LP+MNT I+A +K A+ G + LVDP+VQVSFAG G+T V++++Y P WNE++VFTE+FP LC R+++ + D D V + I TH+IDL +I N+GD GFLPTFGP+WVN+YG+ RNYT +M +ELN GLGEGV++R RLL+ I +L S L + V S+P ++D +C GK E F L GAF EA++ID +I K I FE+S+G GN LD +++N E ++ E+ G+ STT P+TND++YFH+ + E+KPC+Y+ S D + R + NI++K+ ++ + + E ER R++ AL+ S+ C R ++ +T LD++R+K+ LE+M +AK + + T+ + A + ++ L+ PQ+ +PDIFIW L+ TKR+A+ARIPA++ILYS + EE G +V T+FL+ PG+ G GWT+Q +L+ YLWLGL + K F GLP G+ PP + Y ++S F+LRAHM+ AR+L +D +GLSD FAR++ + H +T+V ETL P WDQ L + Y + +PP++V+E+FD+D + GK+EF+GR KP V + E Y+ PR L +++IYRG + AGELLA+FEL+QV P + N P G+ T G ++PVPK IRP L YR+E LFWG+R+++RVQL SVD+PR+ IE + S VI PNFS+ +K+ ++ LPEN L+ PPL I+ D R FGR IL+G+ ++++ K++ P Sbjct: 10 PTAGKPQSYQVSVMIIEARQLVGLNMDPVVIVEVGEEKKQTSQKESTNCPYYNEYFVFDFHTPPNMMFDKIIKLSVIHSKNLIRS----GTLVGTFKLDVGTVYSQPDHRFYHKWAVLTDPDDITAGIKGYVNCDIAVVGKGDNIKTPHKSV-----DNDADSIEGNLLLPEGIPA--DRQWARFFVRIYKAEGLPKMNTAIVANVKKALMGQERDLVDPYVQVSFAGQKGKTSVQRSSYEPVWNEQVVFTELFPPLCRRMKLQIRDSDKVNDTAIGTHFIDLKKICNDGDKGFLPTFGPAWVNMYGSTRNYT---LMDEHQELNDGLGEGVSFRARLLLGISMEILDITSPELSTNTEISVESIPHVADESCSGKMEEFFLFGAFLEATMIDRKISDKL--ISFEISIGNYGNSLDGLNKSNILDRSDDEDEYDEGDEDDETELLNDETDDAEMDDDTSGS---------STTPSYKPETNDRQYFHMPYYEQKPCVYVRSAWHDQRRRLYNSNIIDKIADKLEEGISDVLETMKMERPHPERRLRGALEEM---------SVGCSRFLTLANKDPSAFGRTRLDRDRLKICMRELEQMGPQAK-LGRARTRIHTAPHSTRHTTSSTLRSTAALMAAPQDSIPDIFIWMLVNKTKRVAYARIPAKDILYSIVEEETGKDCGKVKTLFLRLPGKRVFGSGGWTMQAKLEAYLWLGLNKQRKDFLTGLPSGFEEKKIGVTGVPPSVLNYHKRSQFELRAHMYQARSLFAADSTGLSDPFARVIFSTHCKSTEVFQETLCPTWDQLLQFQDVYMYGEPRELRDDPPMVVIEVFDQDTV--------GKAEFIGRALAKPVVKISTEPYEPPRFPPMLDYYQIYRGPVTAGELLASFELLQVPPAD--------------------------------------------NCKFPPVSGLNDTDRGP-IIPVPKGIRPVLAKYRIEVLFWGLRDLKRVQLQSVDRPRVDIECAGKGIQSVVIADFNKNPNFSHLVKFFEVDLPENELFHPPLNIRVVDCRAFGRYILVGSQTVTSLRKFIFHTTGP 1004 HSP 2 Score: 651.358 bits (1679), Expect = 0.000e+0 Identity = 325/600 (54.17%), Postives = 433/600 (72.17%), Query Frame = 3 Query: 4794 HNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDN-RIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 H +E KVY LE EF+ F ++ TF L +G+ D+++ D R+VG FKG+ +YK + ++ + + +++ +P NDP+ +LVR+Y++RA DLHPAD NGK+DPY++++LG + + ENYI KQLNPIFGK F+++ FP ES L +QVMDWDLV DD+IGETKIDLE+RYYS+H+A CG+ Q + HGYN WRD PT +LAKLCK+ D P Y +V VA F E+E+D+G KKQ+ E LAL+V+ +W ++ GC LVPEH+ETRPL + +K GI+QG LEMW+DMFPK++ P P+DI+PR+P SYELR+IIWNT++VIL D +TGEK SDI+V+GW+KG D Q TDVHY SL+GEGNFNWRFI+ FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAKS + C L+ L DGSV ISIFK KR +GWWPF +E+D +EL GK++AE LL+ EE E P GLGRNEP+ L PNRPD+SF+ F+NPLKS+KY+IC+++KW +IK ++ +L LL LFIYN PGY+ K++LGA Sbjct: 1175 HLQVEELKVYDKELE--AEFDNFEDWLHTFNLYRGKTSDEDDILDEERVVGRFKGSTCVYKWPLADNVLKEVGYDAQFGMFQGIPTNDPINVLVRVYIVRATDLHPADINGKADPYIVIKLGKTEVKDNENYISKQLNPIFGKSFDIEATFPMESMLTVQVMDWDLVGMDDLIGETKIDLESRYYSRHRATCGIAQQYAVHGYNTWRDPMKPTQILAKLCKDNKVDGPHY-GPGGRVKVANRIFNGPTEMEDDSGHKKQTEEHLALKVLHSWEEIARVGCKLVPEHVETRPLLHPDKTGIEQGRLEMWVDMFPKDMPHPGPPVDISPRKPKSYELRIIIWNTDEVILEDDAFMTGEKMSDIYVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLVAEEKIVISKKESLFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKSSKQCTLNMLKMDGSVPMISIFKLKRVKGWWPFVSRDENDEQEL--TGKVEAELHLLTAEEAEKNPAGLGRNEPDPLEKPNRPDTSFIWFLNPLKSIKYVICHRYKWIIIKLVVALLMLVLLGLFIYNMPGYMVKKLLGA 1769
BLAST of Otoferlin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004363.1 (pep scaffold:Pmarinus_7.0:GL477737:887:58689:-1 gene:ENSPMAG00000003981.1 transcript:ENSPMAT00000004363.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 693.345 bits (1788), Expect = 0.000e+0 Identity = 408/1146 (35.60%), Postives = 635/1146 (55.41%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEF---------ENPITDRKLSDADD-------ISIDSHGMGSDKRTL-----IDPQTGEIGEFNYGQTD---------NESIESGEDDE-------SFAATNARTLGVPLA-----------------LHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESG---GLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLD--SEANEEEEKE---------------VPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNER-------RGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLT-KVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIW-LIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQV 3266 MALV++LK V+ L + DRI ++ FR T V +D F + F+WP+ ++ +TLE+++Y + K L+ +L+G+ + LQ+L+E ++ E L+D N++ I TV+ EL Y + D + W + +F P D +D I ++H + S R L + P+ + +FN G+ N + E ED + S N T+ + + PT K + +Q+S+ +I A++L G NI+P++ + +G+ K T ++ STN P YN+Y F+F+ + +FD +I+L + + S G IG F++DV TVY+ PDH F HKWA L+DP DI + +GYV+ D+T++GKG+ +K KS ++DD+ +E NL+LP K +RQ A V IYKA LP+MNT I+A +K A+ G K LVDP+VQVSFAG G+T V+ N+Y P WNE++V T++FP LC R+++ + D D V + I +H+IDL++I N GD GF+PTFGP+WVN+YG+ RNYT ++ +ELN GLGEGV++R RLL+ + T L ++ V +P I+D GK E F L GAF EA++ID I +K I FE+S+G GN +D +++N +E + + + + STT PM P+TND++YFH+ + E+KPC+Y+ S D + R + NI++K+ ++ + + E ++ RG M + + F +SI C T LD++R+K+ K + ++ KTM + ++ R ++ L I +PQ+ +PD+FIW L+ TKR+AFARIPA++ILY+ EE G +V T+FL+ PG+ GP GW +Q +L++YLWLG + F G+P G+ PP + Y+++S F+LRAHM+ AR+L +D +GLSD FAR++ + H +T+V ETL P WDQ L + Y + +PP++V+E++D++ M GKSEF+GR KP V + E Y+ PR L +++IYRG + AGELLA+FEL+QV Sbjct: 1 MALVVHLKRVEKLRGKADRIARVTFRGLTFDTNVFENCEDEARFDKIFRWPLATAINGSETLEVQVYNHGKLLSKRLVGTFRMVLQQLVEQGQLELTETLLDENNASIMATVTLELQYQALDGTVGAWSERDFVAFHNRHLIPTPTGDTDTLMPEDETGGDVEIHYNTH-VHSGSRPLRCKKKLKPR--KFLKFNIGRKKSKDDEAAYVNPTFEDSEDSDGSGGMSVSGKGDNLDTISIASGKVETSDVSNKRSKPEQRVDPTAGKPQSYQVSVMIIRAQKLVGLNIDPMVILEVGDAKKKTRIEKSTNCPNYNEYFVFDFNTAPNTMFDTMIKLTVVHNKDAIRS----GTPIGTFKLDVGTVYSQPDHRFYHKWATLIDPDDITADVRGYVQCDITVVGKGDNIKKSHKSI-----ESDDDSLEGNLILPDGCKG--ERQWARFYVNIYKAVGLPKMNTAIVANVKKALMGQEKDLVDPYVQVSFAGQKGKTSVQNNSYEPVWNEQVVLTDIFPPLCRRMKLQIRDSDKVNDVAIGSHFIDLTKICNNGDKGFMPTFGPAWVNMYGSTRNYT---LVDEHQELNDGLGEGVSFRARLLLQLTTELLDKTSPELNNTTEVMVEDIPRINDSVLGKMEEFFLFGAFMEATMIDRSISEKL--ISFEISIGNYGNSIDGLNKSNPQERSDDEDEDDDEDDEEETVLLTAQKAKGTDELSSMFSTTPPMKPETNDRQYFHMPYYEQKPCVYVESTWHDQRRRLYNSNIIDKIADKLDEGISDVKEAMKTDKPHPERRLRGALEEMSSGCERFCSLANKDSSSIDC-------TDLDRKRLKMRLKELIYNIQHSFKTMLCMLFIQIINDMMRVMRNLLSALIACIKDPQHSIPDVFIWMLVNKTKRIAFARIPAKDILYANADEELGKDCGKVKTLFLKLPGKRSFGPGGWAMQAKLEVYLWLGTNKQRNNFLNGMPTGFVEKKSIDPTVPPRVLTYSKRSQFELRAHMYQARSLFAADSTGLSDPFARVIFSTHCKSTEVFQETLCPTWDQLLEYQDVYMYGEPRELRDDPPMVVIEVYDQNTM--------GKSEFIGRALAKPVVKISTEPYEPPRFPPMLDYYQIYRGPLTAGELLASFELLQV 1112
BLAST of Otoferlin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001654.1 (pep scaffold:Pmarinus_7.0:GL479999:3392:42224:1 gene:ENSPMAG00000001492.1 transcript:ENSPMAT00000001654.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 657.907 bits (1696), Expect = 0.000e+0 Identity = 317/579 (54.75%), Postives = 426/579 (73.58%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGR-QDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 EF+ F ++ TF L +G+ +DDD ++R+VG FKG+L +YK E + + +++ +P+NDP+ +LVR+YV+RANDLHPAD NGK+DPY++++LG + +KENYI KQLNP+FGK F+++ FP +S L + + DWDLV DD+IGETKIDLENR YSKH+A CG+ Q + HGYN WRD P+ +LA+LCKE DPP+Y +V VA F A E+E++NG+KK ++E +AL V+ +W ++P C L+PEH+ETRPL + EKPGI+QG +EMW+DMFP ++ P PIDIAPR+P S E+RVIIWNT+DVIL D +LTGEKSSDIFV+ W+KG D Q TDVHY S++GEGNFNWRF+F FDY+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAK+ + C L L DGSV ISIFK KR +GWWPF NE+D EL++ GK++AE LL+ EE E P GLGRNEP+ L PNRPD+SF+ F+ PL+S+KYLIC+++KW ++K ++ LLA+L LF+YN PGY+ K++L Sbjct: 416 EFDNFEDWLHTFSLYRGKIEDDDSSMEEDRLVGRFKGSLCVYKYPLPEELAREVGYDPQFGMFQGIPSNDPIGVLVRVYVVRANDLHPADVNGKADPYIVVKLGKHEVKDKENYISKQLNPVFGKSFDIEAVFPMDSMLTVSIYDWDLVGTDDLIGETKIDLENRLYSKHRATCGISQRYSIHGYNMWRDPLKPSQILARLCKEVKVDPPQYSP-EGRVKVANRTFTAATEVEDENGQKKPTDEHMALTVLHHWEEIPGACKLIPEHIETRPLLHPEKPGIEQGRIEMWVDMFPADVPRPGPPIDIAPRKPKSLEMRVIIWNTDDVILEDDSLLTGEKSSDIFVRSWLKGQQEDKQDTDVHYNSVTGEGNFNWRFVFPFDYLVAEEKIVMSKKESVFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTSKLCSLDMLKTDGSVPMISIFKQKRIKGWWPFAARNEND--ELELTGKVEAEIHLLTSEEAEKSPAGLGRNEPDPLEKPNRPDTSFMWFLTPLRSIKYLICHRYKWLIVKIVLALLLLAMLALFLYNMPGYMVKKLL 991 HSP 2 Score: 259.996 bits (663), Expect = 2.007e-71 Identity = 138/357 (38.66%), Postives = 207/357 (57.98%), Query Frame = 3 Query: 2805 PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSP 3863 PP+ +IY EK FQLR HM+ AR+L +D +GLSD F RI+ + H T+V+ ETL P WDQ L+ D + Y + +PP++V+E+FD+D + GK++F+GR KP V + E+Y +PR L +++IYRG AGELLAAFEL+QV + A R+++P + L G GD+ P G T T G ++PVP+ IRP L YR+E LFWG+R+++R+QL++VD+PR+ +E + S VIPS K PNFS K+ ++ LP+N L PPL I+ D R FGR L+G H ++++ K++++ T+ + I + + P Sbjct: 21 PPISLIYKEKQMFQLRVHMYQARSLFAADSTGLSDPFGRIIFSTHSQATEVIPETLCPTWDQMLVFDSIELYGEAQELRDDPPIIVIEVFDQDTV--------GKADFIGRALAKPVVKMSNEKYDAPRFPPQLDYYQIYRGNSTAGELLAAFELLQVATSPTHHHAP---------RTTAP------------RPATLIPPSG--KGDLPPISGPTDTEHGT-ILPVPRGIRPILSKYRIEVLFWGLRDLKRIQLVTVDRPRVDVECSGKSVQSVVIPSYKQNPNFSTLFKHFEVDLPDNELLHPPLNIRVVDCRAFGRYTLVGTHTVTSLRKFILRAPSKTKAANIRTIGDPNDP 345
BLAST of Otoferlin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001770.1 (pep scaffold:Pmarinus_7.0:GL479034:2422:33544:1 gene:ENSPMAG00000001575.1 transcript:ENSPMAT00000001770.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 342.043 bits (876), Expect = 2.670e-97 Identity = 234/714 (32.77%), Postives = 365/714 (51.12%), Query Frame = 3 Query: 726 KTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDS--KPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTV-FNECIATHYIDLSQIMNEGD------------------------TGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFL------LIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFS-NAVEILHELHMNER-RGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVV-TVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQ 2759 K D+Q+ I VIEARQL G NI P+++V + ++K T ++ N+P++++ F FH+S AELFD++I + L ++ IG F++DV TVY+ P H F KW +L DP+D+ SGAKGY+KV L ++G G++ A + EDIE NLL P G + A + ++ Y+AED+P+M+ ++ T+K DS K LVDP+++VSFAG T TK+ + PEWN+ I FP++C R+R+++YDWD + N+ + T ++ +SQI G TGFLPTFGP ++NLYG+PR +T P EELN G GEGVAYRGR+L+ + T L V PI + E +L L FY A+++ + +PI FE+S+G GN+ D + S Q +R + C S ++L + KP + + SY ED R NIL + N + L E + +A+DT IE+ +L I +V+P LD+E + L + A+ + ++ T+ L E +++L EL PQN +PD+ +W+++ +R+AFARIPA E+++S++ KN + T+ L+ P G+ + GQ+++ +WL L D K+F + Sbjct: 207 KPRDFQVRIRVIEARQLPGNNIKPVVKVTVAGQSKRTRIRKG-NNPFFDETFFFNFHLSSAELFDELIYFKVLHSHSLRAD-----SEIGTFKLDVGTVYDEPRHTFQRKWLLLCDPEDLSSGAKGYLKVTLLVLGAGDEPPEDRSEAV-----EEREDIENNLLRP----AGVSLRGAFLTLRAYRAEDVPQMDDAVLDTVKQIFGFDSNKKNLVDPYLEVSFAGKTLCTKIIEKNANPEWNQAISLPIRFPSMCERLRITLYDWDRLTHNDAVGTAFLSMSQISCPGGDEPEAFITMRCLRLNLLRLIEDEGTGFLPTFGPCFINLYGSPREFT--GFPDPYEELNFGKGEGVAYRGRILVELTTKLEDHINN--------KVEPIPSDDLLRVEKYLRRRRYNLCATFYSATMLR----EVNEPIQFEVSIGNYGNKYDVTC-----PPLASTTQYSR-AVFDGCSS--------------YYLPWGNIKPVVTLTSYWEDVGHRLEALNILMHTQRRLEVNIGRVRATLQAREPVEAVAVSWLHAIDTLIEDCSQALPEITERPNVTP---LDREVWRARSATLALILRSAQRLREEATRVEET--LSELDDWLERLTELTREPQNSIPDVVVWMLRGDRRVAFARIPAHEVMHSSLGPHACGKNCGITQTIVLKYP----QDTHGFKIPGQVRVRIWLSLAADSKSFNE 862
BLAST of Otoferlin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002265.1 (pep scaffold:Pmarinus_7.0:GL483084:292:10410:1 gene:ENSPMAG00000002063.1 transcript:ENSPMAT00000002265.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 281.567 bits (719), Expect = 2.048e-84 Identity = 161/376 (42.82%), Postives = 231/376 (61.44%), Query Frame = 3 Query: 5388 GYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAF-YADAEIEE-DNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGI-QQGSLEMWIDMFPKELGAPPLPIDIAPRQPIS-YELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSV---STISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPS---PNRPDSSFLNFMNPLKSLKYLICNKFKWF 6485 G N+WRD P+M+L + + + P YE +++T+ + +D E + N E LAL ++++ L+PEH+ETR L +S +PG+ QQG L MW+D+FPK +G P P DI PR+ Y+LR IIWNT+DVIL D +TGEK SDI+VKGW+ G Q TDVHYRSL GEGNFNWR+IF F+Y+ AE+ V K+ +++D+TE++ P K +Q+WD D + DD+LG L+L LS +P AKS + C L + T S+F+ K +GWWP E+D K++ + GK++ ++L+ +E E P GLGR EPN P PNRP++SFL F +PLK+ KY+I ++KW Sbjct: 2 GQNQWRDQMTPSMILEGVARAKSWPQPIYEG--DRLTLKGRDYLMSDFEAKAPTNPHLGPVKERLALHLLRSMG-------LIPEHVETRTLEHSIQPGLEQQGKLMMWVDVFPKNMGPPGPPFDITPRKAKKRYQLRCIIWNTKDVIL-DETSITGEKMSDIYVKGWIDGRDDAKQKTDVHYRSLGGEGNFNWRYIFPFEYVPAENICVVSRKEHFWSLDKTELRLPPKFTIQIWDNDKFSPDDYLGYLDLNLSHMPVPAKSAEKCSLEMVETPTGKKKHKTTSLFEQKNVKGWWPCIA--EEDGKKI-IAGKVEMTLEILADKEAEERPAGLGREEPNMNPKLDPPNRPETSFLWFTSPLKTFKYIIWRRYKWI 364
BLAST of Otoferlin vs. Ensembl Nematostella
Match: EDO47415 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLZ1]) HSP 1 Score: 828.935 bits (2140), Expect = 0.000e+0 Identity = 481/1320 (36.44%), Postives = 722/1320 (54.70%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQ---DEFENPI-------TDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNE----------SIESGEDDESFAAT---NARTL-------------------------GVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDIL----SGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVL---RSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSE--------------ANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCV---RHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIR--LKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYS---NDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKS----PRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGK 3812 MALVL LK NL + DRI ++ FR T VV + E F+WP+ LDP + +E+ +Y ++K N+L+G + LQ+L+++ + +E+L+D N+++++ TVS EL Y +P+ I+ W D ++P T R + + I S+G ++ + G N G+ S G+ ES A+ R + G +++H + W I I + EARQLAG I+P+ V +G + K+T ++ TN P+Y+++ F+F M LFD+++ + N+ G LIG F++DV TVY PDH F +WA+L DP++ L +G KGY +VD+T++GKG+ K +P DNDD DIE NLLLP + +R A + +KIY+AE LP+MN+ +MA +K A TG+ + LV+P+V+V FAGH RT VKKNTY P+WNE++VF+E+FP LC RI++ + D D+V +E I TH+IDLS+I N+G GF+PTFGP W NLYG+ R+Y+ + +LN GLGEGVA+RGRLLIA+ SESG +V PISD GK E F L FYEAS+ID ++G K + FE+S+G GN +D + +N + + ++ R + +S T P+ P TND++Y+H+ + + KPC ++ +DH+ R + N+L K+ + + E + T + L I LN IK + HV +T LDKER+KL + +E + A+ + + TK + ++ LK A++++L + PQ+ +PD+FIW++ KR+A++RIP++ I+YS + EE+G + + TVFL+ PG+ G GP GW +Q +L + +WLGL + K + + P GY N PP +IYTEK F LRAH++ AR+LIGSD SGLSDAFAR++ V T+V++ET SP WDQTLI ++ + + I NPP +VVE+FD+D G SEF+GR +P V + E Y+ P L W+++ RG+ NAGE+LAAFEL+QV S + F E+ N TP+ +T PVP IRP + +R+E LFWGVREM+R+ L +VD+P++ I+ + S VI + K PNF NP+ Y D+ LPEN Y PPL I+ D R FGR L+G HV++++ +Y+ G+ Sbjct: 1 MALVLLLKTCTNLHGKADRIARVTFRGVTYQTSVVEHSSEADWDEDFEWPLSSPLDPSEFIEIEVYTFNKIFQNRLVGVFRMVLQRLIQEGHLEVEESLVDMNNTVLKATVSLELQYNAPEGHISQWVNGMPDAMDSPPQVGYYPDTGRDFDNNESIMSGSYGRQPQQQK---ERRGSFMSLNSGKQAKSQSLVSLQSSGSNRRGDRKESMPASVGGGGRYISPGDGGGVAAPFDAMLEGKGIGSRRGSQISVHSDRSMSMKWYIQIRIHEARQLAGTQIDPVCTVSVGNQKKSTTIKEQTNCPFYDEFFVFDFKMPPMVLFDKIVMFQFYTGRNLVSQ----GALIGSFKLDVGTVYAQPDHRFCRRWAVLTDPEETLGASGAGVKGYARVDITVLGKGDPAKEQPGIK-----DNDD-DIEGNLLLPDGVPA--ERPKARVIIKIYRAEGLPKMNSGLMANVKKAFTGEVRDLVNPYVEVQFAGHRARTTVKKNTYEPKWNEQVVFSELFPPLCRRIKIQLKDSDSVTDEVIGTHFIDLSRISNDGANGFMPTFGPCWANLYGSTRDYS---LFDEHNDLNNGLGEGVAFRGRLLIAVHAEFGESASESG--IRQVEVEPTAPISDTAAGKDEQFQLFACFYEASMIDRKVGDKM--VSFEMSIGNWGNSIDGQPIDEVSHATHIQHTSNTQHTQSTMGGDEDRRDGDNPFLYSLTPPVKPVTNDRQYYHIPWEDSKPCTHIKFMWQDHRRRLYNSNVLLKICERLEDGLTDCIERVKMDLPNTFRWLSRVLSELINGCNQYLNLIKSMPTASHVG-RTKLDKERLKLCQYEVESVCTSAQEL-KTSTKDDTHMKDNLKAANALLQRLLNIAVEPQDTIPDVFIWMLCGGKRVAYSRIPSQHIMYSLVEEERGKDSGRMQTVFLRLPGKRGDGPKGWAIQAKLNIMIWLGLHKHKKDYLKDAPKGYQTPKNAHKLMAPPPNHLIYTEKQKFVLRAHVYQARSLIGSDASGLSDAFARVIFTHLVSDTRVIWETRSPTWDQTLIFQEVVLWGDVNEIAVNPPTIVVEIFDKD--------IGGDSEFIGRALARPIVKMACEPYEKPFFPPALEWFQVCRGEENAGEMLAAFELLQV----------------------------TSGTCFLPSEVEPVN---------TPDGPIT---------PVPVGIRPVMKKHRIEVLFWGVREMKRINLTTVDRPQVDIDLAGHVIQSTVITNAKKNPNFQNPVCYFDVELPENERYCPPLTIRVRDCRTFGRFTLVGTHVLNSLHRYLQTGE 1242 HSP 2 Score: 582.793 bits (1501), Expect = 4.554e-173 Identity = 301/590 (51.02%), Postives = 414/590 (70.17%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 K++ LE + +F GF ++ +FPL +G++ +++ D+RIVG FKG+L ++K E + L LP+N+PV +LVR+YV++A +LHP+D NGK+DPYL++ LG + +++NY+ KQLNP FG+CFE + P +S L + + DWDLV DD+IGETK+DLENR+YS+H+A CGL + G+NKWRD PT +LAKLCKE G D P Y +V V F A +I E++G KQS+EP AL +K + + G LVPEH+ETR LFN EKPG++QG LEMW+DMFP ++ +P P+DI PR+P SYELRVIIWNTEDV+L + +LTGEK SDIF+KGW++GL D Q TDVHYRSL+GEGNFNWRFIF F Y KAE++IV K S F+ DE+E K P +L+LQVWDAD +ADDF+G L L L+++PRGAK+ ++C L L +DGSV +S FK K +G+WPF E++ E+++ GK++AE +LL++EE E P G R +P AL PNRPD +++ MNPL+ LK +I N ++ LIK L+I+ LLAL+ LF Y+ PGY K++ GA Sbjct: 1402 MKIFKLELECMHDFNGFNDWLHSFPLFRGKKTSEDDDDDHRIVGKFKGSLKVWKYPLPEHVEMDPIVGTFL--KLPSNEPVNVLVRVYVVKALNLHPSDVNGKADPYLVVNLGKHRVRDRDNYVSKQLNPTFGRCFEFEAIIPMDSMLTVGIYDWDLVGSDDLIGETKVDLENRFYSRHRATCGLQDQYATFGFNKWRDPLRPTQILAKLCKEEGLDGPHYS--TGRVRVDNKVFVAAPQILEESGHWKQSDEPSALRCLKQFQTLKRGFTLVPEHVETRALFNPEKPGVEQGKLEMWVDMFPMDMPSPGAPVDITPRKPTSYELRVIIWNTEDVLLEEANMLTGEKCSDIFIKGWLEGLKDDKQQTDVHYRSLTGEGNFNWRFIFPFQYQKAEERIVITRKASFFSWDESEEKVPARLHLQVWDADAFSADDFIGDLCLDLTRMPRGAKTSKSCTLDLLKQDGSVPQVSFFKMKHMKGFWPFFVNTEEE--EIELAGKVEAELELLTQEEAEKKPAGRAREDPQALEKPNRPDVAWMMMMNPLRGLKAMIWNNYRMCLIKMLVIALLLALMGLFFYSMPGYTVKKIFGA 1985
BLAST of Otoferlin vs. Ensembl Nematostella
Match: EDO43088 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZG6]) HSP 1 Score: 410.994 bits (1055), Expect = 1.870e-116 Identity = 220/558 (39.43%), Postives = 337/558 (60.39%), Query Frame = 3 Query: 4833 LEEVKEFEGFAAFIQTFPLQKG----RQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQ-LNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALP---SPNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 LE+++EF G I +F L +G R DDDEE+ ++VG FKG IY + + E ++ +LP N+P+ +VR+Y++ A DL P DP G +DPY++++LG K ++ K+ Y P LNPIFGK FELD P +L I +MD+DL++ DD+IGET IDLE R ++++A CG+ + + + G N+WRD + P +L + C+E + Y+ + V Y +++E G + NE L + + V N +PEH+ETR L + +P I+QG +++W+D+FPK G +DI R+P +YELRVI+WNT VI+ D +TGE+ SDI+VKGW++G+G D + TDVHYRSL G+GNFNWR +FNF Y+ E K+V + K+ +++D E++ +L +Q+WD D + DDFLG +L L K+P+ ++ + CG + K+G + +F+ +GWW E ++P GK++ ++L+ E P G GR+EPN P PNRP +SFL F +P K+LKY+I +KW Sbjct: 1285 LEKIEEFGGLEDMIASFSLYRGKAKKRDDDDEET--QKVVGEFKGTFRIYPLPEAEGVDPDLPE--TVFTNLPPNEPIDCVVRVYILSAIDLQPQDPGGLADPYVVVQLGKKKLDNKDQYKPNTLNPIFGKMFELDAVIPVHKDLKITLMDYDLLTRDDMIGETVIDLEQRLLTRYRAKCGIPKTYCDSGPNQWRDHKRPMELLREWCEETEKNFKFYKGTKDGTPDRIVVGYRVYQLDE-FGAFRNPNEHLGAKHQRLALHVLNQLEFIPEHVETRGLRSPMQPNIEQGKVQLWVDIFPKNEGVLKPSVDITAREPTNYELRVIVWNTSGVIM-DETSITGEQMSDIYVKGWLEGMGDDKEKTDVHYRSLDGDGNFNWRMVFNFLYLPIEKKMVIREKEHFWSLDAKEVRLAPRLNMQIWDNDTFSYDDFLGSCQLDLIKLPKPCQTAKRCGTSRDPGKNGEY--VDLFQQHSIQGWWACYQEGIEEP-----TGKIEMTIEVLNSNEAAVKPAGKGRDEPNQNPHLDEPNRPATSFLWFTSPFKTLKYIIWRNYKW 1829 HSP 2 Score: 280.026 bits (715), Expect = 1.171e-75 Identity = 206/699 (29.47%), Postives = 340/699 (48.64%), Query Frame = 3 Query: 726 KTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLA-----MGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKM---AITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFN-ECIATHYIDLSQIMNEGDTG-------------FLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRS----ESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNAL--------DTFIENIESSLNSI--KCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDC--------------TKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFG 2672 K +D+QI + ++E RQL+G NI+P++ V + + + T++ STN P YN+ F FH S+AELFD + A G +L G P ++ +A L +++ +GY+KV ++G G++ P A PK+ D++DIE+N L+P G RQ A ++I++AED+P+M++ + +IK I G +K LVDP+V+V+F G T +K PE+ E++ MFP++C RI++ +YDWD V N +CI T ++ LS I +GD G F PTFGP +VN YG+PR ++ ++ + LN+G+GEGVAYRGR+LI ++T L S + + V P ++E + L FYEA++I G P+ FE+S+G GN++D SV N T P P + Y +L + +KP + + S+ ED R N++ +L ++ V+ R+++AL D F+ + S L + C+ HV +L K + L + + D + N+ + E +++L ++ PQN +PD+ +W+I ++R+A+ RIPA+E+L+S P+ G + V + L+ PG+ G Sbjct: 7 KVQDFQIRVKILEGRQLSGNNIHPVVRVAMSNQKRETKIVRSTNKPVYNESFTFNFHTSEAELFDDLFSPAVSAHSYWRWGIRPKKQLFQG-------------LPRPKCAYISSFAFL----NVVFLFQGYLKVTAMVLGPGDE---PPIKAKLPPKEEDEDDIESNCLMPM----GVARQPALFNLRIFQAEDIPQMDSGMGRSIKKFFKGIFGGAKGLVDPYVKVNFCGKKIETSIKYQDDNPEFKEQVKIPLMFPSMCERIKIQLYDWDRVGNDDCIGTAFLSLSSISGQGDEGNELLVILHPSLLCFPPTFGPCFVNFYGSPREFS--ELPDQDDALNKGIGEGVAYRGRVLIELETTLGSNEIEQEVSQIETEDIVRVQPFL-----RREKYKLFACFYEATMIKDVDG----PVEFEVSIGNYGNKMDE-----------SVAPAN-----------TAPSNPLFDGCHYNYLPWGNEKPVVVVESFWEDIAFRLEPLNLISRLCDKLEVNVK---------------RVRSALDAPTPPKEDAFVPMVTSILEVLISDCIPHVG---VLSKSSKHCSYDILGRKVLPLNHRDHDLNLTTELKSALDFPGAEINMEQTVGELNGYLQRLRDVAIEPQNCIPDVIVWMISGSERIAYYRIPAQEVLFSTTPDACGKICGKTVELRLKYPGKKG 630 HSP 3 Score: 167.933 bits (424), Expect = 2.051e-41 Identity = 121/373 (32.44%), Postives = 179/373 (47.99%), Query Frame = 3 Query: 2796 FRRPPMEI----IYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVT-PNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIM-LPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKV-ITNTSSPNQQNNLETPE 3893 FR P + I I FQ+ A+++ AR+L+ DESG++D + R+ + T+V +TL P WDQTLI H+ + S + I NPP +V+E+FD+DQ+ GK +FLGR KP + E + +L W+ I G + GE+LAA EL V S ++ E L N +G V P+ AEG ++PV IRP L VE L WGVR M++ QL S+ P + E G + SD++ K PNF P+ I+ LP +Y PP+ I+ D R FGR + H I ++T++ + PT PA ++ + ++P Q PE Sbjct: 913 FRTPSLSISKSVISCTPHKFQMWAYVYQARDLLAKDESGMNDPYVRVAFANQSQMTEVKQKTLCPTWDQTLIF-HVDLFDSLENIQRNPPTVVMELFDKDQV--------GKDDFLGRTEFKPYPRIHGNEGPACKLLWYPISHGDEDGGEILAACELFLV--------------------------SFIFFQCTTKLETGLLNFHLQDDGVVNIPHPPTPRDAEGE-ILPVRDRIRPVLQKTVVEVLCWGVRNMKKYQLASIKSPSVQFEIGGEIIQSDILTDAKKFPNFGRPILPRKIINLPVEEMYTPPMNIRIHDNRTFGRKPTVAVHSIKSLTRF--RCAAPT--PAGQIQVEGPAAPGQPAEGVVPE 1245
BLAST of Otoferlin vs. Ensembl Nematostella
Match: EDO36863 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHC0]) HSP 1 Score: 332.413 bits (851), Expect = 9.388e-94 Identity = 212/696 (30.46%), Postives = 365/696 (52.44%), Query Frame = 3 Query: 711 HPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIK--MAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTV-FNECIATHYIDLSQIMNEGDTG---------FLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVL----RSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVP--SVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFS-NAVEILHELHMNERRG-THLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKV-CLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGW-TLQGQLKMYLWLGL 2732 H +K +D+Q+ + +IE RQL+G NI+P+ V + +T+ T+V++STN P+Y++ F F+MS ELFD++I +L +IG F+ D+ Y P H + KW +L DP D ++G KGY+KV + ++G G++ K +D++DIE NLL P +G + A +K+Y+AED+P+M++ + IK + + + K LVDP++ SFAG RT++ N+ PE+N+E+ FP++C R+++ ++DWD + ++CI T ++ +S I +G+ G FLP FGP ++N+YG+ R Y+ + ++LN G GEGVAYRGR+L+ ++T L +S + L + ++ SV P ++ + L F EAS++ G P+ FE+S+G GN+LD P +V G C+ Y+ L + + KPC+ + S+ ED R NIL ++ N ++ L N + T + + LD I ++ L I + +P ++ +KL +V +EK+ + + + + ++ L E +++L +L PQN +PD+ IW++ TKR+A+ RIPA ++LY E G +V +F++ PG+ + + ++M +WLGL Sbjct: 8 HKLSNKPQDFQVRVRIIEGRQLSGQNISPVARVTVANQTRQTKVKISTNKPFYDETFFFNFNMSPMELFDEIISFEVFNS-----RKLRANAMIGYFKCDIGFFYEEPGHAAIRKWVLLTDPDDKMAGVKGYLKVTVMVLGPGDEAPVKSAQ-------DDNDDIETNLLQP----SGVMLRPATFSLKVYRAEDIPQMDSGFIEGIKRVLRVGEEQKELVDPYLLFSFAGMKARTRIHYNSDHPEFNQELNVQFKFPSMCERLKLQMFDWDRLTADDCIGTAHLPMSAISGQGEDGESWVERNISFLPMFGPCFINVYGSTREYS--DLPDEYDDLNLGNGEGVAYRGRVLVELETKLGVTPQSPTDDLQS-HEIISVQPYL-----RRRKYKLFACFLEASMVSCSDG----PVEFEVSIGNYGNKLDLSVPPSSSTTPPTNAVYDG--------CY--------------YYFLPWGDTKPCVCVESHWEDIGFRLGTKNILTRMCERLEVNMDKVNLSLEANAQPAETATLLISLLDQLINDVRKPLPKID---NNTPG--VNDLDLKLQEVRLMEKLSISEEAIKLRESATDVREALGEIEGFLQRLRDLTVEPQNSMPDVIIWMLSGTKRIAYYRIPAFDVLYEPYSEACGENCGQVQNIFMKYPGKKQQNIEDYPEVPAHVRMMIWLGL 648 HSP 2 Score: 196.823 bits (499), Expect = 1.465e-50 Identity = 112/331 (33.84%), Postives = 169/331 (51.06%), Query Frame = 3 Query: 2805 PPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKY 3797 P M I Y + +QLRA++F AR+L+ SD G+SD +AR++ T+ + TL P WDQTLI D + Y S + + NPP +++E++D+D + GK EF+GRC KP V L + +PRL W+++ RG GE+LAAFEL V I +++ A+ G+ G P +G+ + VP IRP + +E L WGVR M++ QL SV P I E G + S +I + + PNF PL + D+ LP+ LY PP+ I+ D R FGR ++G H + ++ ++ Sbjct: 901 PRMFITYEKPHRYQLRAYLFQARDLLASDPDGVSDPYARVVFGTRSSVTETLARTLCPTWDQTLIFDEVNIYGSIEQVAENPPAVIIELYDKDPV--------GKDEFMGRCVVKPLVKLNGQGPPAPRLLWYDVERGDEYGGEILAAFELFLV----------SITKVQN------------------------ASKRGNDEGTDLP---FAPPMKGNLFL-VPNGIRPVMQRTAIEVLCWGVRNMKKFQLASVSSPSIEFECGGHVVNSTIIKNTQKNPNFDQPLFFFDVYLPKEELYTPPMNIKVRDNRSFGRKPMVGLHALKSLQRF 1185
BLAST of Otoferlin vs. Ensembl Nematostella
Match: EDO36865 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHC3]) HSP 1 Score: 304.679 bits (779), Expect = 5.150e-93 Identity = 162/328 (49.39%), Postives = 211/328 (64.33%), Query Frame = 3 Query: 5217 FELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEP---LALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQL 6191 FE++ P +L I +MD+DLVS DD+IGET +DLENR+ ++++A CGL Q + G N+WRD Q P +L C+ G P+Y L N V + Y E EE P LAL V+ N +VPEH+ETR L+NS +P I+QG L+MW+D+FPK LG P P +I+PR+P YELRVIIWNT DVIL + + TGEK SDI+VKGW+ G D Q TDVHYRSL GEGNFNWRFIF F Y+ AE +V K K +++DETE + P +L +Q+WD D + DDFLG LEL L+++P+ AKS + C L QL Sbjct: 2 FEMNATIPIIKDLKISLMDYDLVSRDDLIGETVVDLENRFLTRYRACCGLPQTYCTSGINQWRDSQTPRQILDLFCESQGKGRPQY--LGNMKLVLDNRVYTLQEFEEGMIHHPHLGAPEQRLALHVL-------NSMPVVPEHVETRSLYNSLQPNIEQGKLQMWVDIFPKHLGTPGAPFNISPRKPAEYELRVIIWNTSDVILEETSI-TGEKMSDIYVKGWLAGAD-DPQKTDVHYRSLDGEGNFNWRFIFPFMYLPAEKIMVVKKKVHFWSLDETEERVPLRLIIQIWDNDQFSPDDFLGQLELTLNRMPKPAKSARKCNLGQL 318
BLAST of Otoferlin vs. Ensembl Nematostella
Match: EDO34141 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQ91]) HSP 1 Score: 314.309 bits (804), Expect = 1.551e-89 Identity = 193/548 (35.22%), Postives = 303/548 (55.29%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNND---PVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNK---VTVAEVAFYAD--AEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQV-TDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLH-----QLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPD 6413 ++P LE++ +E F+ +FPL++G+ ++E D +VG K + +Y ++++ +V L+ S P++ +VR+Y+I DL D +G DPYL++ +G K + +++Y K LNP+FG+ FE P +L I VMD+D +S DD+IGET IDLE R S + A CGL + + G WRD + P +L ++C + G + P + ++ V V E F + + + ++ E S + L+L + + +VPEH+ETRPL++ +P I+QG L++W+D+FP G+ PI+I PR+P + LRVIIW+T DV L + + TGEK SDI++KGW++ ID+++ TDVHYRSLSG+GNFNWR F F ++ E K+ K + E+K KL +Q+W+ D + DDFLG L L ++P+ + + CG + N D + RGWW + K GK+D ++L+ EE +A PVGLGR+EPN P P+ Sbjct: 407 LTIFPKELEKMG-YEELQDFVSSFPLKRGKAKHEDEE-DEGVVGELKASFRVYPLEEDTRPDDVPR----LHGSHQETHRKWPLKCIVRVYIICGMDLQSQDTDGFGDPYLVVSIGKKEFSTRKDYKKKTLNPVFGEMFEFHASIPSSKDLKITVMDYDRLSRDDLIGETTIDLEQRLLSGYHATCGLPKTYFKSGPYAWRDSKTPKEILREVCLDRGLNRPDFYHKGDQAVTVVVGEDQFNIEDLDDYQLESNELGSSEQRLSLHAL-------HAMGMVPEHVETRPLYSPLQPRIEQGKLQLWVDIFPCTEGSIKPPIEIEPRKPKDFVLRVIIWDTTDVELQETSI-TGEKMSDIYLKGWLE--EIDEKLKTDVHYRSLSGDGNFNWRMEFPFSFLTIEKKLHLSKKKLWGKCE--EVKVDAKLKIQIWENDKFSPDDFLGTRSLPLHRLPKPCSNSRWCGTKYDPGVRQNPDDDFVDLFTLHTHSIRGWWACWQHDSPSGKP---KGKVDMSLEILTAEEAKARPVGLGRSEPNQHPYLPEPE 933 HSP 2 Score: 177.948 bits (450), Expect = 5.441e-45 Identity = 104/284 (36.62%), Postives = 160/284 (56.34%), Query Frame = 3 Query: 726 KTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISR-LLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVF-NECIATHYIDLSQI 1571 K + +Q+ + + E RQ+ G NI+PL+ V +G K ++T V+ STNSP YNQ L F FH S+AELFD+++ L SR L L+G F D+ T+Y PDH FL KW +L S +GY+KV ++G G++ A N+ +NLLLP G +RQ A +++Y AEDLP+ + I+ +K A + K VDP++ SF G +TK + + P +N+ + M P++C I++ ++DWD+ ++CIAT Y+ LS+I Sbjct: 17 KPQHYQVRVKIHEGRQIPGTNIHPLVRVSVGNKKQSTSVKRSTNSPTYNQTLFFNFHASEAELFDELMTLEVFN------SRTFLSDSLLGFFESDIGTLYELPDHAFLRKWVLLTGAGVQESEDEGYLKVTAMVLGPGDEPPLSVFVAIV----NNYNFFGSNLLLP----AGVRRQQAVFQLRVYFAEDLPQ-KSAILFFLKSA--EERKKSVDPYLTFSFCGKQIQTKTQHHENNPVFNQMLQLPVMLPSMCENIKLQLWDWDSFSKHDCIATAYLPLSEI 283
BLAST of Otoferlin vs. Ensembl Medaka
Match: otofa (otoferlin [Source:NCBI gene;Acc:101155482]) HSP 1 Score: 862.448 bits (2227), Expect = 0.000e+0 Identity = 501/1359 (36.87%), Postives = 750/1359 (55.19%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRG-KDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADD----ISIDSHGMGS--DKRTLIDPQTGE--IGEFNYGQTDNESIESGEDDE-------------------------SFAATNARTLGVP-------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGA--KVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLD----------------------------SEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHV---------SPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGY-------SNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEE---PAKKVITNTSSPNQQNNLET 3887 MALV++LK V +L + DRI K++FR ++V D +F E F+WP+ +LD + LE++++ YSK +N+L+G+ + LQK+ E+ + + LID N++ I+ +V+ E+ Y + D W EF DR A + +S SHG S ++ L + G+ G+ N + DE S A+ A T V + + P + D+QISITV+EARQL G N++P++ V +G+ K T ++ STN PYYN+Y F+FH+ LFD++I+L + N+ L G L+G F+MDV TVY P+H F HKWA+L DP DI +G KGYVK D+ ++GKG+ +K K+ + D++DIE NLLLP+ I +RQ A VKIY+AE LP+MNT IMA +K A G+++ LVDP+VQV FAG G+T V+K++Y P WNE+IVFTE+FP LC RI+V + D D V + I TH+IDL +I N+GD GFLPT GP+WVN+YG+ R YT +M ++LN G+GEGV++R RLL+++ +L + S + + + +V V IS+ GK E F L G+F EA+++D +IG K PI FE+++G GN++D SE EEE ++ SV STT M P D+ YFHL + EKKPC+Y+ S+ +D + R + NI++K+ ++ + + E+ E+ R++ L+ S+ C R V + +T LD+ER+K L+ M +AK + K + RLK ++ +++L L PQ+ +PD+FIW++ + KR+A+ARIP+++ILYS + EE G +V FL+ PG+ GP+GWT+Q +L++YLWLG+ R K F GLP G+ F PP+ ++Y+ K FQLRAHM+ AR+L +D SGLSD FAR+ + H T+V+ ETL P WDQ L+ D + + + +PP++VVE++D+D + GK+EF+GR F KPT+ + +E Y PR L +++IYRG AGELLAAFEL+Q+ +G + D+ P EG T + G ++PVP IRP L YR+E LFWG+R+++R+ L VD+PR+ IE + S +I + K PNFS +K+ ++ LPEN L PPL I+ D R FGR IL+G H +S++ +++ T A VI N + Q ++T Sbjct: 1 MALVVHLKKVSHLRGKGDRIAKVSFRGLPLCSRVAENCGDVAHFNETFRWPIASRLDENEMLEIQVFNYSKVFSNRLVGTFCMVLQKVAEEGHLELTDTLIDENNTSIKTSVTIEIRYQAMDGSTGTWIDGEFLEVPDDRDGVFAFETDSLLSGQSHGRCSRPGEKGLWRHKAGKGVFSAMKLGKIKNSKDDHKRADEPAVLDMEDLDRKAKRLAGTLEPDTISLASVTAVTTNVSNKRSKPDIKMEPGSGRPVDYQISITVVEARQLIGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVPPDVLFDKIIKLSVIHSKNL----LRSGTLVGTFKMDVGTVYFQPEHQFYHKWAILSDPDDITAGCKGYVKCDIAVVGKGDNIKTPHKAN-----ETDEDDIEGNLLLPEGIPA--ERQWARFYVKIYRAEGLPKMNTTIMANVKKAFIGENRDLVDPYVQVQFAGQKGKTSVQKSSYEPIWNEQIVFTELFPPLCKRIKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRQYT---LMDEHQDLNEGIGEGVSFRARLLVSVAVEILDTTSPEIISSSDVQVEGVSNISESATGKMEEFFLFGSFLEATMVDRKIGDK--PITFEITIGNYGNQIDGVSKSPAAKKKKKDGENEEDENELILNSSEDEAEEEGDLVSV-------------STTPLMKPVITDRNYFHLPYFEKKPCVYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEIIKTEKAFPERRLRGVLEEL---------SVGCSRFVALANKDVNLAGRTKLDRERLKSCMRELDSMGQQAKQLRTQVKKNTVKDRLKLAQSFLQRLRFLADEPQHSIPDVFIWMMSNNKRIAYARIPSKDILYSTVEEETGKDCGKVKAAFLKLPGKKSFGPAGWTVQAKLELYLWLGVNRQRKDFLSGLPNGFEEVKAVEGGPGF-LSLPPLSLVYSMKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDDVELFGEASELREDPPIIVVEIYDQDTV--------GKAEFIGRTFAKPTIKMCDEHYGPPRFPPQLEYFQIYRGNCTAGELLAAFELLQI--GQGGK------------------------------------------ADLPPIEGSTDSERGP-ILPVPLGIRPVLSRYRIEVLFWGLRDLKRINLAQVDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGTHAVSSLRRFIYSPPDKTSNNWASAGDVIVNLDTEPQIRKMDT 1267 HSP 2 Score: 622.854 bits (1605), Expect = 0.000e+0 Identity = 315/583 (54.03%), Postives = 418/583 (71.70%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGRQDDDEESSDN--RIVGNFKGNLNIYKXXXXXXXXXXXXH--KLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 EF F ++ TF L +G+ DD+E + + RIVG FKG+L +YK+ E + + +++S+P+NDP+ +LVRIYV+RA DLHPAD NGK+DPY+++RLG + +KENYI KQLNP+FGK F+++ FP ES L + V DWDLV DD+IGETKIDLENR+YSK +A CG+ + HGYN WRD PT +L +LCKE D P Y KV VA F EIE++NG KKQ+ E LAL V+ +W ++P GC LVPEH+ETRPL N +KPGI+QG +EMW+DMFP ++ AP +DI+PR+P YELRVIIWNT++VIL D TGEKSSDIFV+GW+KG D Q TDVHY SL+GEGNFNWRF+F F+Y+ AE+KIV K+S F+ DETE K P +L LQVWDAD +ADDFLG +EL L++ PRGAK+ + C L + + + TISIFK KR +GWWPF +E+D E+++ GK++AE L++ EE E PVGLGRNEP+ L PNRPD+S + F+ PLKS++Y I + ++W ++KAL + LL +L LF+Y+ PGYL K++LGA Sbjct: 1378 EFGNFEDWLHTFNLYRGKAGDDDEHALDDDRIVGRFKGSLCMYKLPLSEEITREAGYDPNMGMFQSIPHNDPINVLVRIYVVRATDLHPADINGKADPYIVIRLGKTEVKDKENYISKQLNPVFGKSFDIEATFPMESMLTVSVYDWDLVGTDDLIGETKIDLENRFYSKFRATCGISSSYSVHGYNIWRDPMKPTQILTRLCKEGKIDGPHY-GPGGKVKVANRIFTGPTEIEDENGLKKQTEEHLALTVLNHWEEIPRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPSDMPAPGPALDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFEYLVAEEKIVISKKESMFSWDETEYKIPPRLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSLDMIRNEHELPTISIFKQKRVKGWWPFVARDEND--EMELTGKVEAELHLVTAEEAEKSPVGLGRNEPDPLEKPNRPDTSLMWFLGPLKSIRYFIWHNYRWLILKALGLILLLLMLGLFLYSIPGYLVKKLLGA 1957
BLAST of Otoferlin vs. Ensembl Medaka
Match: otofb (otoferlin-like [Source:NCBI gene;Acc:101160130]) HSP 1 Score: 754.207 bits (1946), Expect = 0.000e+0 Identity = 421/1085 (38.80%), Postives = 641/1085 (59.08%), Query Frame = 3 Query: 654 DDESFAATNARTLGVP------LALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKT-VLRSESGGLPAGAKVY--SVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDS--------EANEEEEKEVPSVNQGNRPKIPK----WCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKF-----RRPPMEIIYTE-KSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPR----LTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVE-FLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGK 3812 D S A+ A T V + + P+ + D+Q+S+TVIEARQL G N++P++ V IGE K T ++ STN PYYN+Y F+FH+ +FD+++++ + N+ L G L+G F++DV T+Y+ P H F HKWA+L DP DI +G KGYVK D+ ++ KG+ +K K+ ++D++DIE+NLLLP+ + +RQ A +KIYKAE LPRMNT IMA +K A G++K LVDP+VQV FAG G+T V+K+ Y P WNE+I FTEMFP LC R+++ + D D V + I TH++DL I N+GD FLPT GP+WVN+YG+ R ++ ++ +ELN GLGEGV++R RLLI++ +L + S + +V VP IS+ GK E F L G+F EA++ID +IG K PI FE+++ GN +D E + +E+E ++ + ++ +TT PM P D YFHL + E+KPC+Y+ S +D K R + NI++ + ++ + + ++E+ E+ R++ L+ + + L ++ S +T LDKER+KL +E + ++AK M K+ + +LK + + KL L PQ+ +PD+FIW+I + KR+A+ARIP+++ILYS+I EEKG +V T+FL+ PG+ G GP+GWT+Q ++++YLWLGL R K + GLP G+ + PP+ + Y K FQLR HM+ AR+L +D +GLSD FAR+ + T+V+ ETL P WDQ L+ +++ + + +PP++V+E++D+D + GK++F+GR F KP V + +E Y PR L +++IYRG AGE+LAAFEL+Q+ P NG D+ P +G T G ++PVP IRP L YR+E LFWG+R+++RV L VD+PR+ IE + S +IP+ K PNFS +K+ ++ LPEN L PPL I+ D R FGR L+G++ +S++ K++ +G+ Sbjct: 23 DTISLASVTAVTTNVSNKSKPEIKMEPSSGRPVDYQVSVTVIEARQLVGLNMDPMVCVEIGEDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKVSVIHSKNL----LRSGTLVGTFKLDVGTIYSQP-HQFYHKWALLSDPDDITAGGKGYVKCDIAVVAKGDTIKTPHKAN-----ESDEDDIESNLLLPEGVPA--ERQWARYYLKIYKAEGLPRMNTSIMANVKKAFIGENKDLVDPYVQVQFAGQKGKTSVQKSCYEPIWNEQIAFTEMFPPLCRRMKIQLRDSDKVNDVAIGTHFLDLRNISNDGDK-FLPTLGPAWVNMYGSTRTFS---LLDEYQELNDGLGEGVSFRARLLISLGVEILDTSSPEISCSTEVQVEGVPNISESATGKVEEFFLFGSFLEATMIDRKIGDK--PINFEVTI-YYGNEIDGALQPKPKGEKGKGDEEETELIHNSSEEEMEDDGDLTSVATTPPMKPVITDN-YFHLPYFERKPCIYIKSLWQDQKRRLYNSNIIDNIADKLEDGLNDVNEIIKTEKAYPERRLRGVLEELSQGCQF-LALANKDQNQSGRTKLDKERLKLCLSEVEAIGLQAKAMRSQVKKSTVRDKLKLSQNFLSKLRFLADEPQHSVPDVFIWMISNGKRIAYARIPSKDILYSSIDEEKGKDCGKVKTIFLRIPGKKGFGPAGWTVQSKIEIYLWLGLTRQRKDYLNGLPNGFEENKLSKGPGLPSTPPISLTYMSVKQIFQLRVHMYQARSLFAADSTGLSDPFARVFFSTQSQVTEVLAETLCPTWDQLLVFENVELFGEAVELRDDPPIIVIEIYDQDTV--------GKADFMGRTFAKPVVKMADEHYGPPRFPPQLEYYQIYRGNCAAGEMLAAFELLQIGP-------NG-------------------------------------KADLPPIDGPTDMDRGP-ILPVPLGIRPVLSKYRIEQVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSALIPNFKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSNAVSSLRKFIYRGQ 1033 HSP 2 Score: 555.444 bits (1430), Expect = 1.621e-165 Identity = 280/533 (52.53%), Postives = 375/533 (70.36%), Query Frame = 3 Query: 4815 KVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESS---DNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSP 6401 +VYP LE EF+ F ++ TF L +G+ DD++ + ++RIVG FKG++ +YKV D+ + +++++PNNDPV +LVRIYV+RA DLHPAD NGK+DPY+ ++LG I +KENYI KQLNP+FG F+++ FP +S L + + DWDLV DD+IGETKIDLENR+YSKH+A CG+ NHGYN WRD PT +LAKLCK+ D P Y +V V F A EIE++N KK+++E LAL V+ +W ++P GC LVPEH+ETRPL + +KPGI+QG +E+W+DMFPKE+ AP +DI+PR+P +ELRVIIWNT++V+L D + TGEKSSDIFV+ W+KG D Q TDVHY S++GEGNFNWRF++ FDY+ AE+KIV K+S FA DETE K P +L LQVWDAD +ADDFL +EL L++ PRGAK+ + C + + + + +SIFK KR +GWWPF NE+D E ++ GK++AE LL+ EE E P G GRNEP L P Sbjct: 1111 EVYPKELE--SEFDNFEDWLHTFYLFRGKAGDDDDQTVADEDRIVGKFKGSMCMYKVSDDAPRDMSFDSNMGMFQNIPNNDPVNVLVRIYVVRATDLHPADINGKADPYIAIKLGKTEIKDKENYISKQLNPLFG-SFDVEATFPMDSTLTVSIYDWDLVGTDDLIGETKIDLENRFYSKHRATCGVA----NHGYNVWRDPMKPTHILAKLCKDGKLDGPHY-GPGGRVKVENRVFMAPTEIEDEN-LKKKTDEHLALCVLTHWEEIPRVGCKLVPEHVETRPLLHPDKPGIEQGRIELWVDMFPKEMTAPGPALDISPRKP-KFELRVIIWNTDEVVLEDDDIFTGEKSSDIFVR-WLKGQQEDKQDTDVHYHSITGEGNFNWRFVYPFDYLMAEEKIVISKKESMFAWDETEYKIPPRLNLQVWDADHFSADDFL-AIELDLNRFPRGAKTAKQCTIEMVTNEAEMPMVSIFKQKRIKGWWPFVARNEED--EFELTGKVEAELHLLTGEEAEKSPAGEGRNEPEPLEKP 1629
BLAST of Otoferlin vs. Ensembl Medaka
Match: ENSORLT00000022822.2 (pep primary_assembly:ASM223467v1:21:28315623:28320348:1 gene:ENSORLG00000018220.2 transcript:ENSORLT00000022822.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 444.891 bits (1143), Expect = 1.460e-138 Identity = 252/577 (43.67%), Postives = 360/577 (62.39%), Query Frame = 3 Query: 4848 EFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPN-GCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRML 6575 +F F ++ T+ L +G+ +++E SSD R VG FK +YK+ +EE+G D + + +P N PVQ+L+R+YV+ A++LHPADP+GK+DPY++LRLG I +++NYIPKQLNP+FG FE+ FPQES L + + D+DLV GDD+IGET+IDLENR+YS+H+A CGL + + GYN WRD P+ +L+K+C+E G D P++ K++VA+ F+ + + +S E L+L+++ WS++P GC LVPEH+ETR L+N +PG+ QG ++MW+DMFP +L P P+DI+PR+P YELR+IIWNTEDVIL D LTG++SSDI+VK +V + +D+ F++D+TE K P L LQVWD + +++DDFLG LEL L P GAK+ + C L G ISIF+ KR RGWWPF+ E + GK++AEF L++ EE E PVG R EP LP P RPD+SF FMNP K +L+ +K ++I ALI+ L L L Y PG ++++M+ Sbjct: 9 DFGQFDDWVNTYELFRGKANEEEGSSDERFVGKFKARFCLYKLAEEEWGEGSDPGFFRVSRGIPANSPVQVLIRVYVVSASNLHPADPDGKADPYIVLRLGKNEIKDRDNYIPKQLNPVFG-SFEMQATFPQESLLSVVIYDFDLVGGDDLIGETRIDLENRFYSRHRATCGLPTEY-SEGYNAWRDSLKPSELLSKMCRENGLDAPRFSP--GKISVADKVFHGKTLYMHE--QPVESYEHLSLKILHRWSEIPAVGCKLVPEHIETRVLYNKARPGMDQGQVQMWVDMFPMDLPHPGPPVDISPRKP-KYELRIIIWNTEDVILDDSNFLTGQQSSDIYVK-----------------------------------------VVVVRKRDNIFSLDKTEQKLPAILILQVWDFETLSSDDFLGTLELDLHGFPPGAKTAKACKAEMLT--GRTERISIFQQKRARGWWPFSKSGE-------LTGKVEAEFHLVTAEEAEKNPVGRARKEPEPLPKP-RPDTSFSWFMNPFKCFFHLVWRNYKKYIITALILFILALFLALLFYTLPGAISQKMI 527
BLAST of Otoferlin vs. Ensembl Medaka
Match: myof (myoferlin [Source:NCBI gene;Acc:101172285]) HSP 1 Score: 332.028 bits (850), Expect = 8.251e-92 Identity = 223/700 (31.86%), Postives = 367/700 (52.43%), Query Frame = 3 Query: 711 HPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIK--MAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVF-NECIATHYIDLSQIMNEG----------DTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVE-----ILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKN-SEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTF 2753 H K +D+QI + V+EARQL G NI P+++V + +T T ++ S N+P++++ + HM ++LF+Q I R ++ L+ GEF++DV VY+ P H + KW +L DP D SGAKGY+KV L ++G G++ K+ D+D +DIE+NLLLP G + A + +K+++AED+P+M+ + +IK + K LVDPF++ FAG T++ + PEWN+ + FP++C R++++V+DWD + N+ + T Y+DL++I + G + GFLP FGP ++NLYG+PR +T + P ++LN G GEGVAYRGR+L+ + T L ++ + IS + + L F+ AS+I + +PI FE+S+G GN+LD+ K STT+ + +Y++L + KP + + S+ ED R NI+ + + + +E IL ++ N+ L++ LD IE++E + S T LD + K + L ++ M Q+ ++ + L + + KL +L PQN +PD+ IW+++ KR+A++RIPA EIL+S E+ KN + TVFL+ P G + Q+++ +WLGL D K F Sbjct: 167 HRLATKPQDFQIRVRVVEARQLPGNNIKPVVKVHVCGQTHRTRIK-SGNNPFFDEMFFYNVHMLPSDLFEQSISFRVYNSYSLRADSLM-----GEFKLDVGYVYDEPAHCVMRKWLLLNDPDDSSSGAKGYLKVSLFVIGTGDE-----PLVEKRDCDDDQDDIESNLLLP----AGMTLRWATLSLKVFRAEDIPQMDDAFVQSIKEIFGAEENKKNLVDPFLEARFAGKKLCTQIIEKNANPEWNQVLHLQVKFPSMCERVKLTVFDWDRLTGNDAVGTTYLDLAKIASSGGEIEGNPVESEVGFLPVFGPCYINLYGSPREFT--GLPDPYDDLNFGKGEGVAYRGRILVELSTKLDEKAEKTIDNIHIKRTSIISI----LRRKYCLCAVFHSASMIQ----EPGEPIQFEVSIGNYGNKLDTTC--------------------KPLASTTQYSCAVFDGNQYYYLPWANTKPVVVLTSFWEDISHRLNAVNIILCITHRLQSNLEAFKVAILAKVPDNKLAEVWLQL---LDQLIEDLERF--PTPELEGCSNLTSLDIQLKKRRDITLNSIKEAVLRMRQEASE--IRDTLSDIETWVDKLKQLAEEPQNSMPDVVIWMLRGEKRVAYSRIPAHEILFSTYSEQACGKNCGKTQTVFLKYPMD---KAKGLKVPVQIRVSMWLGLSADEKKF 811 HSP 2 Score: 156.377 bits (394), Expect = 1.893e-37 Identity = 105/362 (29.01%), Postives = 167/362 (46.13%), Query Frame = 3 Query: 2790 FKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAK--KVITNTSSPNQ 3869 F P + + + LR +++ ARNL+ D+ SD +A + TT+ + TL+P WDQTLI + + Y I PP +V+E +DEDQ+ GK E LGR C P V L E +SPRL W I + AGE+L A ELI L + GD + + P + AE ++ VP+ IRP + VE L WG+R M+ QL SV P + +E G + + +I + K PNF + ++ ++LP++ +Y PP++++ D R FGR ++G I+++ + + E A+ K+ +SP++ Sbjct: 1071 FGANTPTVSCTFDRSYMYHLRVYVYQARNLMSMDKDSFSDPYAHVSFLHVSKTTEKLKATLNPTWDQTLIFNSVEIYGDPQKIAHRPPDVVLEFYDEDQV--------GKDEMLGRSICTPLVKLSPEMDQSPRLFWHPIIQKGQRAGEVLVAAELI------------------------------------------LKDKSGDSDLPLLP----PMRAENLYM--VPQGIRPVVQLTAVEILAWGLRNMKPYQLASVSSPSLVVECGGQRVETAIIKNMKKSPNFPGNILFIKVLLPKDEMYTPPIVLKVIDHRPFGRKPVVGQCTIASLEDFRCDPYVIVSEGARSSKMALMMASPHK 1376 HSP 3 Score: 70.8626 bits (172), Expect = 2.085e-11 Identity = 40/103 (38.83%), Postives = 56/103 (54.37%), Query Frame = 3 Query: 4812 FKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGK 5120 KVY LE V EF+G F TF LQ+G+ D+ +E D +VG FKG +Y + D+ ++ LP + P + LVRIY++R DL P D NG+ Sbjct: 1424 LKVYDNELENVPEFKGLTDFCNTFKLQRGKNDNGDE--DPTVVGEFKGAFKVYPLPDDPGIAPPPRQ----FRELPESGPQECLVRIYIVRGIDLQPKDNNGR 1520
BLAST of Otoferlin vs. Ensembl Medaka
Match: myofl (myoferlin [Source:NCBI gene;Acc:101156429]) HSP 1 Score: 314.309 bits (804), Expect = 1.007e-85 Identity = 209/572 (36.54%), Postives = 302/572 (52.80%), Query Frame = 3 Query: 4806 ERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFK-GNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYE----ALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQL-NKDGSVST----ISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPS--PNRPDSSFLNFMNPLKSLKYLICNKFKWF 6485 + KVY C LE+V++F+G F +T L +G+ DD+E D +VG FK G+ IY + D+ +K LP + P + LVRIYV+R ++ D NGK DPY+ + LG K +++++NY P L+P FG FEL PQ+ +L I V D+D S D+ +GET IDLE+R S + CGL Q + + G N+WRD P+ +L + K G PP E +L+ + +A+ I G +K E L+L V++N LVPEH+ETR L +S K + QG ++MW+D+FPK LG P P +I+PR+ Y LRVIIWNT DVIL D + T EK+SDI+VK E +NW D+TE ++P KL +Q+WD D ++ DD+L +EL L ++ AK+P+ C L L G+V++ S+F K RGWWP N + + GK++ +++ ++E E P G GRNEPN P P RP +SF F N LK++ KF+W Sbjct: 1307 DTLKVYNCELEKVEQFQGLTDFCRTINLHQGKTVDDDE--DPSVVGQFKQGSFKIYPLSDDPSVPAPPCQ----FKELPESGPQECLVRIYVVRCIEVQSKDSNGKCDPYIKITLGKKTLDDRDNYKPNTLSPEFGM-FELSCTLPQDKDLKIAVYDFDKWSRDEEVGETVIDLEDRLLSYFRPCCGLPQTYCS-GVNQWRDQLKPSQILQNVAKMRGVPPPSIEEDGRSLLFSGKRYHLQDFANILIHSHLGPEK---ERLSLHVLRNLG-------LVPEHVETRTLSSSYKSNLSQGRIQMWVDIFPKRLGLPGPPCEISPRK-AKYFLRVIIWNTSDVILDDASI-TAEKTSDIYVK---------------------QEQFWNW--------------------------DKTEYRNPPKLIVQIWDNDRISLDDYL-SVELDLLRLVPPAKTPEKCTLKMLPGMKGTVASKAKPTSLFSRKSVRGWWPCA--NAQNGSCVLTQGKVEMTLEIVDEKEAEERPAGRGRNEPNMNPKLDPPRPATSFAWFTNVSSILKFMTRIKFRWI 1808 HSP 2 Score: 252.677 bits (644), Expect = 8.155e-67 Identity = 197/698 (28.22%), Postives = 325/698 (46.56%), Query Frame = 3 Query: 714 PTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAI--TGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEG---DTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVP--PISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILH---ELHMNERRGTHLRMKNALDTFIENI-----ESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEK-GVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQ 2759 P + +D+QI + VIE R L G +I P++ V KT T V+ N+P++++ + +MS ++L D+ H + KW +L DP D GA+GY+KV + IMG G++ + + + +D+E+NLL+P G + A + +K+Y+AED+P+ + + T+K + GD K LVDP+++VSFAG TK+ + PEWN+ I V ++ I T +++LSQI + G + GFLP FGP +VNLYG+PR Y + EELN G GEGVAYRGR+L+ + T L + V +P + ++ + L F+ A ++ G PI FE+++G GN+LDS +P + +T P D Y++L + + KP + + SY ED R NIL ++ + + +L E R T + +K LD IE + E LN T+LD ++ L + + + A M ++ ++ + + + ++ +L PQN +PD+ IW+ + KR+A+AR+PA +ILYS+ ++ G ++ T+F+Q P G + +L+ +WLGL K F + Sbjct: 143 PLASEAQDFQIRVRVIEGRHLPGIDIKPVVRVLFDGKTHRTNVR-GGNNPFFDEMFFYNVNMSLSDLSDE--------------------------------------HAIMRKWLLLKDPDDSTMGARGYLKVSIIIMGTGDEAPIENRLFRA-----EQDDLESNLLVP----AGVSMRTATLSLKVYRAEDMPQDDATVQ-TLKQFLGGEGDKKNLVDPYLEVSFAGKKVCTKIIQKNANPEWNQLISLN-------------------VKDDVIGTTFLNLSQISHSGGNVEVGFLPAFGPCFVNLYGSPREY--GDLPDRFEELNFGNGEGVAYRGRVLVELSTHLDKK-----VEKNVDDIPRDDVLVAQFQRRRRYSLCSVFHSACMLQEPGG----PIRFEVTLGNYGNKLDSTC---------------KPLV------STTPNCFAVFDNHYYYLPWADTKPVVILTSYWEDISHRLDAINILLFTADQLESNLNLLKTAISAKEPESRLTEIWLK-LLDHIIEELVLPALEDRLNV----------TVLDLQKKNLREAAVYNIMQMACCMKEEAR--DIGSTVADIEDWLDRIKQLAEEPQNSMPDVIIWMFRGEKRVAYARVPANQILYSSFSKQACGKHCGKIQTIFMQYPMDKN---KGVKIPAELRFNMWLGLSVHEKEFSR 724 HSP 3 Score: 72.7886 bits (177), Expect = 5.583e-12 Identity = 42/131 (32.06%), Postives = 65/131 (49.62%), Query Frame = 3 Query: 2841 FQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAG 3233 + LR +++ RNL D + S +A + TT V+ TL+P WDQTLI + + + + S PP +V+E++D DQ+ GK E +G C P + L+ P+L W I + NAG Sbjct: 980 YHLRVYIYQGRNLCPMDHNSFS-PYAHVSFLHMSKTTHVIQNTLNPIWDQTLIFEDIEIHGDPQTVASCPPEVVLELYDSDQV--------GKDEPMGHCKYPPLINLQPNIGCRPKLQWLPITKKGHNAG 1101 HSP 4 Score: 52.373 bits (124), Expect = 7.521e-6 Identity = 31/109 (28.44%), Postives = 59/109 (54.13%), Query Frame = 3 Query: 3474 VPKEIRPSLVPYRVE-FLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKY 3797 VP+ I+P + +E L WG+R M+ QL V P + +E G + + +I + K PNF + + +LP+ +Y PP++++ D + FG ++G I ++ ++ Sbjct: 1132 VPQGIKPVVQLTAIEQVLTWGLRNMEAFQLSPVSSPSLIVECGGETVKTAIIKNFKKNPNFPGSVLLL-KLLPKEEMYAPPIVLKVIDHKPFGWKPVVGQCTIRSLGEF 1239
BLAST of Otoferlin vs. Planmine SMEST
Match: SMESG000037807.1 (SMESG000037807.1) HSP 1 Score: 4113.53 bits (10667), Expect = 0.000e+0 Identity = 2156/2162 (99.72%), Postives = 2160/2162 (99.91%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIXXXXXXXXXXXXXXXXXGLGVVELKKKAKIPKDELQDIDWWSRYYVXXXXXXXXXXXXXXXXNLDVLKDIEVDVKSDDDQGGLAEIPEDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXGIFAKLPFGRVXXXXXXXXXXXXXXXXXXXNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 MALVLNLKYVDNLDNRCDRI+KINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIA+WRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNES+ESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGI RIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGD+TPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIPEIVPVKPKESVVEPIKGLGVVELKKKAKIPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDD EDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKVDDEEFGVEVDVHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFLIKALIISALLALLVLFIYNAPGYLAKRMLGA Sbjct: 1 MALVLNLKYVDNLDNRCDRIVKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIANWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESVESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIPRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDITPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIPEIVPVKPKESVVEPIKGLGVVELKKKAKIPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDDFEDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKVDDEEFGVEVDVHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFLIKALIISALLALLVLFIYNAPGYLAKRMLGA 2162
BLAST of Otoferlin vs. Planmine SMEST
Match: SMESG000037807.1 (SMESG000037807.1) HSP 1 Score: 4091.58 bits (10610), Expect = 0.000e+0 Identity = 2148/2162 (99.35%), Postives = 2152/2162 (99.54%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIXXXXXXXXXXXXXXXXXGLGVVELKKKAKIPKDELQDIDWWSRYYVXXXXXXXXXXXXXXXXNLDVLKDIEVDVKSDDDQGGLAEIPEDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXGIFAKLPFGRVXXXXXXXXXXXXXXXXXXXNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 MALVLNLKYVDNLDNRCDRI+KINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIA+WRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNES+ESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQM GKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGI RIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGD+TPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIPEIVPVKPKESVVEPIKGLGVVELKKKAKIPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDD EDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKVDDEEFGVEVDVHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFLIKALIISALLALLVLFIYNAPGYLAKRMLGA Sbjct: 1 MALVLNLKYVDNLDNRCDRIVKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIANWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESVESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQM--------GKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIPRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDITPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIPEIVPVKPKESVVEPIKGLGVVELKKKAKIPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDDFEDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKVDDEEFGVEVDVHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFLIKALIISALLALLVLFIYNAPGYLAKRMLGA 2154
BLAST of Otoferlin vs. Planmine SMEST
Match: SMESG000037807.1 (SMESG000037807.1) HSP 1 Score: 4011.84 bits (10403), Expect = 0.000e+0 Identity = 2115/2162 (97.83%), Postives = 2119/2162 (98.01%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIXXXXXXXXXXXXXXXXXGLGVVELKKKAKIPKDELQDIDWWSRYYVXXXXXXXXXXXXXXXXNLDVLKDIEVDVKSDDDQGGLAEIPEDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXGIFAKLPFGRVXXXXXXXXXXXXXXXXXXXNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKXXXXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFXXXXXXXXXXXXXXXXXXXXXPGYLAKRMLGA 6581 MALVLNLKYVDNLDNRCDRI+KINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIA+WRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNES+ESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGI RIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGD+TPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTE DDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIPEIVPVKPKESVVEPIKGLGVVELKKKAKIPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDD EDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKVDDEEFGVEVDVHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFLIKALIISALLALLVLFIYNAPGYLAKRMLGA Sbjct: 1 MALVLNLKYVDNLDNRCDRIVKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIANWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESVESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISRLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGPSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIPRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDITPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMSVDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTE-----------------------------------------DDETTAAGNLSSARKSSTNFNSNVQALLDNAKMLQDATQNSAVSQTNLNNSKTNLSQAGILMNSSEKIGKLDSQSINDTKLKQISPTPNTPPETPIHHPNYKDDKRPLVNSDTKSETKFGVKILKSIPEIVPVKPKESVVEPIKGLGVVELKKKAKIPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDDFEDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDNRIVGNFKGNLNIYKVDDEEFGVEVDVHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKWFLIKALIISALLALLVLFIYNAPGYLAKRMLGA 2121
BLAST of Otoferlin vs. Planmine SMEST
Match: SMESG000010367.1 (SMESG000010367.1) HSP 1 Score: 918.687 bits (2373), Expect = 0.000e+0 Identity = 491/1327 (37.00%), Postives = 777/1327 (58.55%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITDRKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESG--EDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAIS-RLLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDE-DIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEG---DTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLRMKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMG-PSGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMS----------------VDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDDETTAAGNLSSARKSSTN 4004 M+L +NLKY+D D+ +K+ FRD EK + ++ +IYFG++F WP+ RK+D D L L+ Y ++ +KL+G + I+ L+ + ++ +ENL+D I I V+FE+ Y+SP + ++ D F P+ + K + S K TL + + E Y D + ++ +D + R +P + P K ED+QIS+T++EAR L G NINP+ EV G++ + TE++M TNSP+YN++ F+ MS+ E+ + +I++R L+ N ++ R+ G ++GEF +D ++VY H F KWA L+DPK SG KGYVKVD++++ G++ DN++ +IEANLL+P + + T R+M E+ V IY+AEDLP MNT+I++ IK AI G+ K L D +V+VSFAG+TGRTKV Y+P+WN++I+FTE FP R+R++V D D V +E I+T +IDL +IM G + GFLPT+GPSW+NLYGTPR +TY Q+++ + N+ L EGVAYRGRL+IAIKT + +S + G V P+S+ GK+E +LL G YE ++I+ ++GK +P+ FE+S+G TGN LD A E + + HS T+ T D +YFH+ + KKPCL+MI+ EDH+ R FIPNI+EKLK E S + L + + +K ++ I +IE ++ +K R + KT+LD + +L ++ LEKM+VK + + + ++N+ +++EC ++K L + + +PQ GLPDIFI++IQ+ R+A+ARI AREI++S++ EKG+ + TV+L++ + + + +Q QL++YLWLGLLRDM+ ++ GLP GY+ +CF + PP I Y ++S FQLR ++FMARN+IGSD+SGLSD FARI++ +HV + + +T SP WD+TLIID++IF Y+ D++ S+PP +VVE+FD D T EFLGR FC+P V ++ ++Y + +L WW IYRG + AGE+LAAF+L+++ G+ ++ + + +S I R G++ N+ + +P+ IRP L +R E L WGVR++QR++++ V++P+ITI+ + SD I ++PNF + L ++D+ LP + +WPP+ I C + FG ++GN I+N+ Y ++ K + S N D EG+ N + +++ +A L+ ++ N Sbjct: 1 MSLSVNLKYLDGAAQGGDKYIKLMFRDVEKKSNRLKTSANIYFGQRFNWPIARKMDKNDILILKCYNANRVGGDKLLGVLQIATGNLINEPSMNVRENLVDERMKITDIIVAFEIEYFSPSTGSDNFGSDAFNFPVYNLK----------TLKRTSKKVTLPSENSSDEDEEYYDSDDGDGRDNNIRDDISDISLLPDRDFKLPKHIDPQSLKIEDFQISVTIVEARGLCGNNINPMFEVYCGKQKQNTEIKMQTNSPFYNEFFTFDLTMSRLEMMELIIKIRGLSKSNNVVAQRIFTGKVLGEFSIDAKSVYTNEGHSFFRKWAPLIDPKSPTSGEKGYVKVDISVLCAGDK------PKRPDADDNEENPNIEANLLIPLCV-SNTPRKMCEMAVLIYQAEDLPCMNTNIISNIKHAIYGEGKALTDAYVEVSFAGYTGRTKVVNRNYSPDWNQQIIFTERFPPFVTRLRIAVRDNDMVKDETISTIFIDLQKIMYTGSKEEEGFLPTYGPSWINLYGTPRTFTYTQLIKGDQGQNQNLAEGVAYRGRLMIAIKTSYQPDSSKI--GVDVRPCNPVSNTVAGKREMYLLFGGIYETTLINEDLGKNGKPLTFEMSIGITGNLLDDYAKPTPENQ--------------YVHSMTQSRFAYTYDNKYFHIPYKNKKPCLFMITQSEDHRPRMFIPNIIEKLKRELSEIIRQTSHLRLEKNIQARRYLKTSIINLIPSIEKVVSGVKSCRGTAKKTMLDVKYQRLIRLDLEKMKVKLQNLALELKRSNVYEKMRECNTLVKLLEDKMADPQYGLPDIFIYMIQENIRVAYARIKAREIIHSSMAPEKGIMCGMMNTVYLKRLDNSLLKLNTSYNIQAQLQIYLWLGLLRDMRGYKMGLPEGYNRECFSGKMPPKYIDYLDESMFQLRVYLFMARNVIGSDDSGLSDPFARIIIGEHVAKSTIFTQTRSPIWDETLIIDNIIFNYAPDVLKSSPPNVVVEIFDWDSDT--------DEEFLGRVFCQPKVYIKGDQYTTAKLQWWSIYRGTLAAGEILAAFDLVEMDMKTKKITVKGLPTVKDIKKMTSEINDNRF-------------------GEMDENK-----------LRIPEFIRPHLSTFRFEILMWGVRQLQRIEVVHLKKNPFVASKRFGIFPVNQPKITIDIAGYRIESDKITDWTIQPNFEDNLVFLDLRLPTSTQFWPPISINCTNSTVFGLKQIVGNCAITNLVDYYQCDQVDNFREIDKTTIDERSVKSLNLFNAGNDT-------EGILNEGFENEDGSAINELTDMKEEKPN 1249 HSP 2 Score: 538.88 bits (1387), Expect = 1.860e-157 Identity = 278/607 (45.80%), Postives = 391/607 (64.42%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSDN--RIVGNFKGNLNIYKXXXXXXXXX-------------------------------------XXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPK--------ELDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 IER +YPC LE VK+F GF ++F L +G+Q++D+++ +N R G FKGN+ IY +D E+ L LYK+L + +PV +VR+Y+I+A +LHP+D NGKSDPY+L++LG+K + ++ENYIPK LNP+FGKC EL+V FPQES LL+Q+ DWD ++ DD+IGET IDLENR+ S H+ CG+ + NHGY KW+D +LPT++L LC+E+ P Y+ L ++V + + +F+A+ IE+D+G + +S EPLALEV+ +W ++ G LVPE++ETRPL+ EKPGIQQG LEMW+DM+P A P PIDI PR+ I YELR + TE V L + T EK+ DIFVK WMK ID Q TDVHY+SLSG+G FNWRF++NFDY+KAED IVY K S + IDE E K+PC L +QV D+ ++ +D +G + LSK P+ AK ++C QL++ + + ++F+NK+ RGWWP +PK ++ G ++ E +L++ EE E+ PVGLGR EP L +P RPD SFL+F+NP ++KY I + KW Sbjct: 1390 IERITMYPCELENVKDFGGFHDPFKSFSLYRGKQEEDDDNFENPDRFGGVFKGNICIYNIDPEDAEDIDDEEEEDDFNDEDDEEEREEKERRREERELEKQEREDEKKKTLRLYKNLRDINPVDFVVRVYIIKAINLHPSDLNGKSDPYILVKLGDKEVRDRENYIPKTLNPVFGKCIELEVTFPQESFLLVQIYDWDRLTKDDLIGETTIDLENRWLSPHQGSCGIMPSYHNHGYLKWKDYRLPTVILKSLCEEHNVPLPIYDKLTDRVDIDDRSFFAETMIEDDDGSQIKSLEPLALEVLHHWHEIVPGKKLVPEYIETRPLYMPEKPGIQQGLLEMWVDMYPAG-TAIPAPIDITPRKAIGYELRCTVIQTEKVRLINVNFFTNEKTVDIFVKSWMKSTDIDLQKTDVHYKSLSGQGLFNWRFVYNFDYLKAEDCIVYTQK-SVYEIDECEYKTPCFLNMQVLDSGIIMSDTIIGKFKCRLSKFPQPAKFYRSCDPFQLSE--ACAKFNLFRNKKVRGWWPLIY----NPKDEDSDEEDGEEIGGCVELEMELVTAEEAESNPVGLGRAEPMPLEAPMRPDGSFLSFLNPWNTIKYFIKYRLKW 1988
BLAST of Otoferlin vs. Planmine SMEST
Match: SMESG000010400.1 (SMESG000010400.1) HSP 1 Score: 896.345 bits (2315), Expect = 0.000e+0 Identity = 497/1342 (37.03%), Postives = 783/1342 (58.35%), Query Frame = 3 Query: 96 MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIADWRQDEFENPITD-----------RKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESIESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISR-LLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVXXXXXXXXXXXXDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDT---GFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLR-MKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGP--SGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIQRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDVTPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMS----------------VDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDD-----ETTAAGNLSSARKSSTN 4004 M+L++ L+ + + + +K+ FRD + T + K S G +F WP+ RKLD +D+L ++ +++ +KL G + I L L+ I+ E +D I I ++FE+ Y SP S + + +F P + R SD + DS ++ ID + G+ NY + + R +P + P K +D+QIS+T+ EAR L+G NINPL EV G++ + TE++M TN+P+YN+Y F+F +S+ EL +Q+IR++ L+ + ++R + PG +IGEF +D +TVY+ H F +KWA+L+DPK SG KG+VKVDL+++ G++ K +D +IEAN+L+PQ I T+R + E+ V +Y+AEDLP MNT IM+ IK AI GD K L DP+V+VSFAG+TG TKV +Y+P+WN++I+FTE FP +R+R++V D D + +E I+T +IDL +IMN + GFLPT+GPSW+NLYGTPR Y+Y +M++ + N+ L EGVA+RGRLLIAIKT S+ + G V S P+S+ GK+E +LL + +EA++I EIGKK++P+ FELS+GTTG +E +P + + + HS TEP T D +YFH+ + KKPCLYMI+ EDH+ R FIPNIL+KLK E V ++ L ++ +R +K +++TF +I+ L++IK R + KTLLD + KL ++ LEKM++ + + + + +K+ + +K L++ + +PQ+GLPD+F+++IQD R+A+ RI AR++++SAIP EKG V TV+L+K F + P + + +Q QL++YLWLGLL+DM+ ++ GLP G+ DCF + PP I Y E+S FQLR +++M RNLIGSD+SGLSD F ++++ +H+ + V +ET SP WD+T+IID+++F Y+ ++ + PP +V+E+FD D T EF+GR FC+P+V + +EY S +L WW +YRG M AG++L +F+LI++ P G +E ++ ++ + NS + E L +P ++RP + +R+E L WGVR++QR++++S V++PRI IE G + SD+I PNF++ L + + LP N +WPP+ I C + FG ++GNHVI+++ +Y ++ KI N ++ ++L++ + + A +GV N A+ + E T AG S A+ TN Sbjct: 1 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVKDGD----NYSE--------------LSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDK-----PKRPNKTDKEEDPNIEANILIPQ-ILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTT--SQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG------ICPDEYSHLPKKEENFESQ---YVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKK-MNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTD--------EEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVN---DNSKGEKDEEKLR---------------------------IPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKI-----------NEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTN 1257 HSP 2 Score: 556.599 bits (1433), Expect = 1.245e-163 Identity = 283/598 (47.32%), Postives = 384/598 (64.21%), Query Frame = 3 Query: 4803 IERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD--NRIVGNFKGNLNIYKXX----------------------------XXXXXXXXXXHKLMLYKSLPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKE--------LDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLICNKFKW 6482 IER K+Y C LE +K++ GF ++F L +G+Q+++++ + +R G FKGN+ IY V E + + L LYK L + V +VR+YV++ +LHPAD NGK+DPY+L+R+GNK I ++ENYIPK LNPIFG+CFE++V FPQES LL+QV DWD ++ DD+IGET IDLENR+ S H+ CGL + NHGY KW+D QLPT +L LC++ PPKY+ + + V + F +D+ IE+D+G + +S EPLAL V+ NW + C LV EH+ETRPL+ EKPGI+QG LEMW+DMFP PP PIDI+PR+P SYELR++I TE+V L+D T EKS DI++K WMK ID Q TD H+RSLSG+G FNWRF+F FDY+KAED IVYK K+ + IDE E K+PC L +QV D+DL+ +D +G L+ LSK P+ AK ++C Q + + ++FKNK+ RGWWP +PK+ L++ G ++ E L+ EE E+ P GLGR EP L PNRPD SFLNF+NP ++KY I + KW Sbjct: 1391 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDENKTEEELLNEKSNLKLYKFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPP-PIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVY----NPKDEDEEEENGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRLKW 1980 The following BLAST results are available for this feature:
BLAST of Otoferlin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Otoferlin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Otoferlin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Otoferlin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Otoferlin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Otoferlin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Otoferlin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Otoferlin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003490 ID=SMED30003490|Name=Otoferlin|organism=Schmidtea mediterranea sexual|type=transcript|length=6689bpback to top protein sequence of SMED30003490-orf-1 >SMED30003490-orf-1 ID=SMED30003490-orf-1|Name=SMED30003490-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=2163bp MALVLNLKYVDNLDNRCDRIMKINFRDFEKTTKVVRGKDSIYFGEQFQWPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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