Glycine N-methyltransferase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003448 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Glycine N-methyltransferase vs. Ensembl Human
Match: GNMT (glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415]) HSP 1 Score: 342.813 bits (878), Expect = 4.759e-117 Identity = 180/316 (56.96%), Postives = 217/316 (68.67%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTN---GFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 MVD +YRTRSLGVA GLPDQYADG+AA+VW+LY+G + RT+ YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V S DASDKMLK ALKERWNRRHE FD+WVIEEANW+TL K +P + GFDAVICLGNSFAHLPD GDQSE ++AL N+ ++R G+LVIDHRNYD+IL TG AP GKN+YY SD K + TS L V+ K M+TLDYT+ + G + P LS+ FRLSYYPH L FTELLQ F K + V GDF+ + P Y+IHV+ + Sbjct: 1 MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLD---------KDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGS----PGLSK----------FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKR 293
BLAST of Glycine N-methyltransferase vs. Ensembl Fly
Match: Gnmt (gene:FBgn0038074 transcript:FBtr0082651) HSP 1 Score: 309.301 bits (791), Expect = 2.270e-104 Identity = 159/310 (51.29%), Postives = 209/310 (67.42%), Query Frame = 3 Query: 153 VDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKDPAYYIHVMTK 1079 D ++ RS G++ G+ DQYADGKAAKVWE+++G K RT YK + I++L+N VLDVACGTGVDS+ML+EEGF V+S DASDKMLK ALKERW RR+E FD+WVIEEANWLTL D+ +GFDAVICLGNSFAHL D GDQ E + A+ N + L+P G+L+IDHRNYD IL+TG P K++YY + H IKTS LF GKP ++++DY + + +E FRLSYYPH L RF E+L +F K K ++YGDF++++++K+PA+YIH++ K Sbjct: 5 ADSVFVARSDGISAEGVRDQYADGKAAKVWEIFIGDKNSRTDNYKNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYALKERWARRNEAAFDKWVIEEANWLTLYDDIQEHI------QDGFDAVICLGNSFAHLMDGFGDQREHKQAIGNFEKCLKPGGVLLIDHRNYDNILETGATP-AKSIYYNTSHTADIKTSVLFYCGKPALVSMDYLIAGNKLTSE---------------------FRLSYYPHGLKRFQEILAEIFSAKAKHQLYGDFKEMSQVKNPAFYIHLIEK 286
BLAST of Glycine N-methyltransferase vs. Ensembl Zebrafish
Match: gnmt (glycine N-methyltransferase [Source:ZFIN;Acc:ZDB-GENE-040227-1]) HSP 1 Score: 343.584 bits (880), Expect = 1.488e-117 Identity = 181/312 (58.01%), Postives = 219/312 (70.19%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLTKIKD-PAYYIHVMTK 1079 MVD +YRTRSLGV GLPDQYADGKAAKVW+LY+G + RT YK W + LL+ H V VLDVACGTGVDS+ML+EEGF+V+S DASDKMLK ALKERW RR E FD WVIEEANWLTL +D+ P +GFDAVICLGNSFAHLPD GDQS+Q++AL N+ +++P GIL+IDHRNYDYI++TGQ P+GKN+YY SD + I TS L+V+ KP MITLDYT+ + P E Q FRLSYYPH ++ F E+L+ F K E VY DF+ T + P Y+IHV+ K Sbjct: 1 MVDSVYRTRSLGVGAVGLPDQYADGKAAKVWQLYIGDTRSRTEEYKSWVLALLRKHGVQRVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYALKERWERRKETAFDNWVIEEANWLTLPEDVKK-------PGDGFDAVICLGNSFAHLPDFKGDQSDQKLALQNIGSMVKPGGILIIDHRNYDYIIETGQVPQGKNIYYKSDLKQDISTSVLWVNSKPHMITLDYTL----------VLPQP---EGAQTPPDTSKFRLSYYPHRVENFKEILKAAFWGKCEHNVYADFKQYTAGGEPPCYFIHVVKK 292
BLAST of Glycine N-methyltransferase vs. Ensembl Xenopus
Match: ENSXETT00000024750.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV461671.1:2929:3138:-1 gene:ENSXETG00000015000.1 transcript:ENSXETT00000024750.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 108.612 bits (270), Expect = 5.398e-29 Identity = 45/69 (65.22%), Postives = 54/69 (78.26%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTG 356 MVD +YRTRSLGV GLPDQYADG+AA+VW LY+G K+ RT Y+ W ++LL+ HN VLDVACGTG Sbjct: 1 MVDSVYRTRSLGVGAEGLPDQYADGRAARVWHLYIGDKRSRTDEYRSWILSLLQEHNCRTVLDVACGTG 69
BLAST of Glycine N-methyltransferase vs. Ensembl Mouse
Match: Gnmt (glycine N-methyltransferase [Source:MGI Symbol;Acc:MGI:1202304]) HSP 1 Score: 342.813 bits (878), Expect = 2.827e-117 Identity = 178/313 (56.87%), Postives = 214/313 (68.37%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 MVD +YRTRSLGVA GLPDQYADG+AA+VW+LY+G + RT+ YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V+S DASDKMLK ALKERWNRR E FD WVIEEANWLTL + V+ +GFDAVICLGNSFAHLPD GDQSE ++AL N+ ++RP G+LVIDHRNYDYIL TG AP GKN+YY SD K I TS L V+ K M+TLDYT+ + G + F FRLSYYPH L FTEL++ F + + V GDF+ + P Y+IHV+ K Sbjct: 1 MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVMSVDASDKMLKYALKERWNRRKEPSFDNWVIEEANWLTLDK--------DVLSGDGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGTGRDGSP--------------GFSKFRLSYYPHCLASFTELVRAAFGGRCQHSVLGDFKPYKPGQAYVPCYFIHVLKK 291
BLAST of Glycine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q9QXF8|GNMT_MOUSE (Glycine N-methyltransferase OS=Mus musculus OX=10090 GN=Gnmt PE=1 SV=3) HSP 1 Score: 342.813 bits (878), Expect = 1.977e-116 Identity = 178/313 (56.87%), Postives = 214/313 (68.37%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 MVD +YRTRSLGVA GLPDQYADG+AA+VW+LY+G + RT+ YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V+S DASDKMLK ALKERWNRR E FD WVIEEANWLTL + V+ +GFDAVICLGNSFAHLPD GDQSE ++AL N+ ++RP G+LVIDHRNYDYIL TG AP GKN+YY SD K I TS L V+ K M+TLDYT+ + G + F FRLSYYPH L FTEL++ F + + V GDF+ + P Y+IHV+ K Sbjct: 1 MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVMSVDASDKMLKYALKERWNRRKEPSFDNWVIEEANWLTLDK--------DVLSGDGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGTGRDGSP--------------GFSKFRLSYYPHCLASFTELVRAAFGGRCQHSVLGDFKPYKPGQAYVPCYFIHVLKK 291
BLAST of Glycine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q14749|GNMT_HUMAN (Glycine N-methyltransferase OS=Homo sapiens OX=9606 GN=GNMT PE=1 SV=3) HSP 1 Score: 342.813 bits (878), Expect = 2.285e-116 Identity = 180/316 (56.96%), Postives = 217/316 (68.67%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTN---GFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 MVD +YRTRSLGVA GLPDQYADG+AA+VW+LY+G + RT+ YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V S DASDKMLK ALKERWNRRHE FD+WVIEEANW+TL K +P + GFDAVICLGNSFAHLPD GDQSE ++AL N+ ++R G+LVIDHRNYD+IL TG AP GKN+YY SD K + TS L V+ K M+TLDYT+ + G + P LS+ FRLSYYPH L FTELLQ F K + V GDF+ + P Y+IHV+ + Sbjct: 1 MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLD---------KDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGS----PGLSK----------FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKR 293
BLAST of Glycine N-methyltransferase vs. UniProt/SwissProt
Match: sp|P13255|GNMT_RAT (Glycine N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Gnmt PE=1 SV=2) HSP 1 Score: 341.273 bits (874), Expect = 7.562e-116 Identity = 179/314 (57.01%), Postives = 214/314 (68.15%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPT-NGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 MVD +YRTRSLGVA G+PDQYADG+AA+VW+LY+G + RT+ YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V S DASDKMLK ALKERWNRR E FD+WVIEEANWLTL K +P +GFDAVICLGNSFAHLPD GDQSE ++AL N+ ++RP G+LVIDHRNYDYIL TG AP GKN+YY SD K I TS L V+ K M+TLDYT+ + G + F FRLSYYPH L FTEL+Q F + + V GDF+ + P Y+IHV+ K Sbjct: 1 MVDSVYRTRSLGVAAEGIPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRKEPAFDKWVIEEANWLTLD---------KDVPAGDGFDAVICLGNSFAHLPDSKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGAGRDGAP--------------GFSKFRLSYYPHCLASFTELVQEAFGGRCQHSVLGDFKPYRPGQAYVPCYFIHVLKK 291
BLAST of Glycine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q29555|GNMT_PIG (Glycine N-methyltransferase (Fragment) OS=Sus scrofa OX=9823 GN=GNMT PE=2 SV=1) HSP 1 Score: 339.732 bits (870), Expect = 3.711e-115 Identity = 176/309 (56.96%), Postives = 209/309 (67.64%), Query Frame = 3 Query: 162 IYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVF-QNKKEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 +YRTRSLGVA GLPDQYADG+AA+VW+LY+G + RT+ YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V S DASDKMLK ALKERWNRRHE FD+WVIEEA + + PK P GFDAVIC GNSFAHLPD GDQSE ++AL N+ ++R G+LVIDHRNYD+IL TG AP GKN+YY SD IK I TS L V+ K M+TLDYT+ + G P LS+ FRLSYYPH L FTELLQ F N + V GDF+ + P Y+IHV+ K Sbjct: 2 VYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEA-----NWMTLDKDVPKS-PMGGFDAVICQGNSFAHLPDCRGDQSEHRLALKNITSMVRSGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLIKDITTSVLTVNNKAHMVTLDYTVQVPGTGHRGS----PGLSK----------FRLSYYPHCLASFTELLQTAFGGNGQHSVLGDFKPYKPGQAYIPCYFIHVLRK 290
BLAST of Glycine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q29513|GNMT_RABIT (Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus OX=9986 GN=GNMT PE=2 SV=1) HSP 1 Score: 323.168 bits (827), Expect = 1.008e-108 Identity = 175/314 (55.73%), Postives = 211/314 (67.20%), Query Frame = 3 Query: 156 DRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIP---TNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNK-KEKVYGDFQDLTKIKD--PAYYIHVMTK 1079 D +YRTRSLGVA GLPDQYADG+AA+VW+LY+G + RTS YK W + LL+ H VLDVACGTGVDS+ML+EEGF+V S DASDKMLK ALKERWNRRHE FD+WVIEEANW+TL K +P GFDAVICLGNSFAHLPD GDQSE + AL N+ ++R G+LVIDHRNYD+IL T AP GKN+YY SD K + TS L V+ K M+TLDYT+ + + P LS+ FRLSYYPH L FTE L+ F+ K + V GDF+ + P Y+IHV+ + Sbjct: 1 DSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTSEYKTWLLGLLRQHGCRRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLD---------KDVPQPAGGGFDAVICLGNSFAHLPDCKGDQSEHRQALKNIASMVRTGGLLVIDHRNYDHILSTLCAP-GKNIYYKSDLTKDVTTSVLTVNNKAHMVTLDYTVQVPAAGQDGP----PSLSK----------FRLSYYPHCLAPFTEFLRAAFEGKCQHSVLGDFKPYQPGQAYVPCYFIHVLKR 290
BLAST of Glycine N-methyltransferase vs. TrEMBL
Match: H3AJK9 (Glycine N-methyltransferase OS=Latimeria chalumnae OX=7897 GN=GNMT PE=3 SV=1) HSP 1 Score: 363.229 bits (931), Expect = 5.519e-122 Identity = 181/313 (57.83%), Postives = 226/313 (72.20%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLTKIKD--PAYYIHVMTK 1079 MVD +YRTRSLGVA GLPDQYADGKAA+VW+LY+G + RT Y+ W LLK H VLDVACGTGVDS+M+LEEGF+V+S DASDKMLK ALKERW+RR E+ FD+WVIEEA + PK P +GFDAVICLGNSFAHLPD GDQS+Q++ALAN+ +++P GIL+IDHRNYDYIL+TG+AP GKN+YY SD K I TS L+V+G P MITLDYT+ + + E E+ + + FRLSYYPH LD FTELL++ F+ K E +V+GDF+ + ++ P Y+IHV+ K Sbjct: 1 MVDSVYRTRSLGVAAEGLPDQYADGKAARVWQLYIGDTRSRTDEYRNWLRALLKEHGCQQVLDVACGTGVDSIMMLEEGFSVVSVDASDKMLKYALKERWDRRKEEAFDKWVIEEA-----NWLTLMRDVPK--PKDGFDAVICLGNSFAHLPDFKGDQSDQKLALANIAGMVKPGGILIIDHRNYDYILQTGRAPPGKNIYYKSDLTKDITTSVLWVNGNPHMITLDYTVQVP-------------VGEVEEQQPEMSKFRLSYYPHRLDAFTELLKSTFKGKCEHRVFGDFKPYKRNQEYVPCYFIHVLQK 293
BLAST of Glycine N-methyltransferase vs. TrEMBL
Match: A0A3P9L7D3 (Glycine N-methyltransferase OS=Oryzias latipes OX=8090 PE=3 SV=1) HSP 1 Score: 361.688 bits (927), Expect = 1.979e-121 Identity = 190/314 (60.51%), Postives = 228/314 (72.61%), Query Frame = 3 Query: 147 IMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLT--KIKDPAYYIHVMTK 1079 + VD ++RTRSLGVA GLPDQYADGKAAKVWELY+G Q RT YK W ++LLK H V VLDVACGTGVDS+ML+EEGFN++S DASDKMLK ALK RW+RR E FDQWVIEEANWLTLQ D++ P +G+DAVICLGNSFAHLPD GDQSEQ++AL N+ ++RP GIL+IDHRNYDYIL+TG+AP+GKN+YY SD + I TS L+V+ KP MITLDYT+ + + + LP +S+ FRLSYYPH LD F ELL+ F K E VYGDFQ + + P Y+IHV K Sbjct: 1 MSVDSVFRTRSLGVAAEGLPDQYADGKAAKVWELYIGDTQSRTQEYKSWVVSLLKQHGVRTVLDVACGTGVDSIMLVEEGFNMVSVDASDKMLKYALKARWDRRKESAFDQWVIEEANWLTLQADIHK-------PADGYDAVICLGNSFAHLPDFKGDQSEQKLALHNIASMVRPGGILIIDHRNYDYILETGRAPQGKNIYYKSDLTQDITTSVLWVNSKPHMITLDYTIHV----PQAEHNNLPEVSK----------FRLSYYPHRLDNFRELLKEAFSGKMEHSVYGDFQTYVPGRSQPPCYFIHVCKK 293
BLAST of Glycine N-methyltransferase vs. TrEMBL
Match: A0A3B3H9X6 (Glycine N-methyltransferase OS=Oryzias latipes OX=8090 GN=gnmt PE=3 SV=1) HSP 1 Score: 361.688 bits (927), Expect = 1.979e-121 Identity = 190/314 (60.51%), Postives = 228/314 (72.61%), Query Frame = 3 Query: 147 IMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLT--KIKDPAYYIHVMTK 1079 + VD ++RTRSLGVA GLPDQYADGKAAKVWELY+G Q RT YK W ++LLK H V VLDVACGTGVDS+ML+EEGFN++S DASDKMLK ALK RW+RR E FDQWVIEEANWLTLQ D++ P +G+DAVICLGNSFAHLPD GDQSEQ++AL N+ ++RP GIL+IDHRNYDYIL+TG+AP+GKN+YY SD + I TS L+V+ KP MITLDYT+ + + + LP +S+ FRLSYYPH LD F ELL+ F K E VYGDFQ + + P Y+IHV K Sbjct: 1 MSVDSVFRTRSLGVAAEGLPDQYADGKAAKVWELYIGDTQSRTQEYKSWVVSLLKQHGVRTVLDVACGTGVDSIMLVEEGFNMVSVDASDKMLKYALKARWDRRKESAFDQWVIEEANWLTLQADIHK-------PADGYDAVICLGNSFAHLPDFKGDQSEQKLALHNIASMVRPGGILIIDHRNYDYILETGRAPQGKNIYYKSDLTQDITTSVLWVNSKPHMITLDYTIHV----PQAEHNNLPEVSK----------FRLSYYPHRLDNFRELLKEAFSGKMEHSVYGDFQTYVPGRSQPPCYFIHVCKK 293
BLAST of Glycine N-methyltransferase vs. TrEMBL
Match: A0A3P9JEI3 (Glycine N-methyltransferase OS=Oryzias latipes OX=8090 PE=3 SV=1) HSP 1 Score: 361.303 bits (926), Expect = 2.900e-121 Identity = 190/314 (60.51%), Postives = 228/314 (72.61%), Query Frame = 3 Query: 147 IMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLT--KIKDPAYYIHVMTK 1079 + VD ++RTRSLGVA GLPDQYADGKAAKVWELY+G Q RT YK W ++LLK H V VLDVACGTGVDS+ML+EEGFN++S DASDKMLK ALK RW+RR E FDQWVIEEANWLTLQ D++ P +G+DAVICLGNSFAHLPD GDQSEQ++AL N+ ++RP GIL+IDHRNYDYIL+TG+AP+GKN+YY SD + I TS L+V+ KP MITLDYT+ + + + LP +S+ FRLSYYPH LD F ELL+ F K E VYGDFQ + + P Y+IHV K Sbjct: 1 MSVDSVFRTRSLGVAAEGLPDQYADGKAAKVWELYIGDTQSRTQEYKSWVVSLLKQHGVRTVLDVACGTGVDSIMLVEEGFNMVSVDASDKMLKYALKARWDRRKESAFDQWVIEEANWLTLQADIHK-------PADGYDAVICLGNSFAHLPDFKGDQSEQKLALHNIASMVRPGGILIIDHRNYDYILETGRAPQGKNIYYKSDLTQDITTSVLWVNSKPHMITLDYTIHV----PQAEHNNLPEVSK----------FRLSYYPHRLDNFRELLKEAFSCKMEHSVYGDFQTYVPGRSQPPCYFIHVCKK 293
BLAST of Glycine N-methyltransferase vs. TrEMBL
Match: A0A1A8F5H2 (Glycine N-methyltransferase OS=Nothobranchius korthausae OX=1143690 GN=GNMT PE=3 SV=1) HSP 1 Score: 361.303 bits (926), Expect = 3.234e-121 Identity = 185/314 (58.92%), Postives = 232/314 (73.89%), Query Frame = 3 Query: 147 IMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLTKIKD--PAYYIHVMTK 1079 + VD ++RTRSLGVA GLPDQYADGKAAKVWELY+G Q RT YK W ++LL+ H V VLDVACGTGVDS+ML+EEGFN++S DASDKMLK ALK RWNRR E FDQWVIEEANWLTL +D+ P +GFDAVICLGNSFAHLPD GDQS+Q++AL N+ ++RP GIL+IDHRNYDYIL+TG+AP+GKN+YY SD + I TS L+V+ KP MITLDYT+ + + ++ KLP +S+ FRLSYYPH L+ F++LL + F K E +VYGDF++ ++ P Y+IH+ + Sbjct: 1 MSVDSVFRTRSLGVAAEGLPDQYADGKAAKVWELYIGDTQSRTQEYKSWLVSLLRQHGVRRVLDVACGTGVDSIMLVEEGFNMVSVDASDKMLKYALKARWNRRKEAAFDQWVIEEANWLTLPEDVQK-------PGDGFDAVICLGNSFAHLPDFKGDQSDQKLALHNIGSMVRPGGILIIDHRNYDYILETGKAPQGKNIYYKSDLTQDISTSVLWVNSKPHMITLDYTIQV----PQAELQKLPEVSK----------FRLSYYPHRLESFSQLLMDAFGGKMEHRVYGDFKEYVPGQNQAPCYFIHICKR 293
BLAST of Glycine N-methyltransferase vs. Ensembl Cavefish
Match: gnmt (glycine N-methyltransferase [Source:ZFIN;Acc:ZDB-GENE-040227-1]) HSP 1 Score: 311.997 bits (798), Expect = 1.554e-105 Identity = 163/294 (55.44%), Postives = 204/294 (69.39%), Query Frame = 3 Query: 207 DQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKEK-VYGDFQDLTKIKD--PAYYIHVMTK 1079 D YADGKAAKVW+LY+G + RT Y+ W LL+ HN VLDVACGTGVDS+ML+EEGF + S DASDKMLK ALKERW RR E FDQWVIEEANWLTL +D+ P +GFDAVICLGNSFAHLPD GDQS+Q++AL N+ +++P GIL+IDHRNYDYIL+TG+AP+GKN+YY SD + I TS L+V+ KP M+TLDY++++ +E + FRLSYYPH L+ F ELL+ F K E+ V+GDF+ + P Y+IHV+ K Sbjct: 3 DSYADGKAAKVWQLYIGDTRRRTDEYRSWLAGLLRQHNCIRVLDVACGTGVDSIMLVEEGFKMFSVDASDKMLKYALKERWERRKEPAFDQWVIEEANWLTLSEDVQK-------PGDGFDAVICLGNSFAHLPDFKGDQSDQKLALCNIASMVKPGGILIIDHRNYDYILETGRAPEGKNIYYQSDLKQDISTSVLWVNSKPHMVTLDYSLEVP-------------QAEGAHTPPETSKFRLSYYPHQLESFKELLKEAFLGKCEQSVFGDFKQHKPGQGDAPRYFIHVVKK 276
BLAST of Glycine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010933.1 (pep scaffold:Pmarinus_7.0:GL476423:348413:348622:1 gene:ENSPMAG00000009906.1 transcript:ENSPMAT00000010933.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 102.834 bits (255), Expect = 8.654e-28 Identity = 42/69 (60.87%), Postives = 51/69 (73.91%), Query Frame = 3 Query: 150 MVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTG 356 MVD ++RTRSLGV GLPDQYADG+AA+VW+LY+G Q RT Y+ W LL +H +LDVACGTG Sbjct: 1 MVDNVFRTRSLGVPAEGLPDQYADGRAARVWQLYIGDTQSRTDEYRAWLTKLLSDHGCKRILDVACGTG 69
BLAST of Glycine N-methyltransferase vs. Ensembl Nematostella
Match: EDO33266 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSQ7]) HSP 1 Score: 328.176 bits (840), Expect = 6.569e-112 Identity = 170/310 (54.84%), Postives = 216/310 (69.68%), Query Frame = 3 Query: 153 VDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKEKV-YGDFQDLTKIKDPAYYIHVMTK 1079 +D +YRTRSLGV +G+PDQYADGKAAKVW+ Y+G ++RT Y+E+F NLL+ N+ NVLDV+CGTGVDS+MLLE GF V S DASDKMLK AL+ RWNRR E+ FD+WVIEE NWL L P GFD +ICLGNSFAHLPD GD + Q+VA+ N L+P G L+IDHRNYD I+ TG+AP KN+YY S+ I+ IKTS L VDG+ TM+TLDYT+D + E++ SE E FRLSY PH L F+ LL+++F E + +GDF+ L KI++PAYY+H++ K Sbjct: 1 MDGVYRTRSLGVPATGIPDQYADGKAAKVWQHYIGGHKKRTESYREFFCNLLRERNIHNVLDVSCGTGVDSIMLLENGFCVTSVDASDKMLKDALRIRWNRRKEEPFDKWVIEEGNWLYLDDADIEP------PEGGFDGIICLGNSFAHLPDFNGDLANQRVAMTNFMNFLKPGGWLIIDHRNYDAIIDTGKAPS-KNLYYNSECIEDIKTSVLLVDGRATMVTLDYTVDTSKANIEKE-------SESEP-------FRLSYCPHRLANFSNLLKDIFGKNAEHITFGDFKPLGKIENPAYYVHLIQK 289
BLAST of Glycine N-methyltransferase vs. Ensembl Medaka
Match: gnmt (glycine N-methyltransferase [Source:NCBI gene;Acc:101154832]) HSP 1 Score: 361.688 bits (927), Expect = 7.450e-125 Identity = 190/314 (60.51%), Postives = 228/314 (72.61%), Query Frame = 3 Query: 147 IMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIKTSNLFVDGKPTMITLDYTMDITGIMTEQQIFKLPLLSEEEQYELKFQNFRLSYYPHTLDRFTELLQNVFQNKKE-KVYGDFQDLT--KIKDPAYYIHVMTK 1079 + VD ++RTRSLGVA GLPDQYADGKAAKVWELY+G Q RT YK W ++LLK H V VLDVACGTGVDS+ML+EEGFN++S DASDKMLK ALK RW+RR E FDQWVIEEANWLTLQ D++ P +G+DAVICLGNSFAHLPD GDQSEQ++AL N+ ++RP GIL+IDHRNYDYIL+TG+AP+GKN+YY SD + I TS L+V+ KP MITLDYT+ + + + LP +S+ FRLSYYPH LD F ELL+ F K E VYGDFQ + + P Y+IHV K Sbjct: 1 MSVDSVFRTRSLGVAAEGLPDQYADGKAAKVWELYIGDTQSRTQEYKSWVVSLLKQHGVRTVLDVACGTGVDSIMLVEEGFNMVSVDASDKMLKYALKARWDRRKESAFDQWVIEEANWLTLQADIHK-------PADGYDAVICLGNSFAHLPDFKGDQSEQKLALHNIASMVRPGGILIIDHRNYDYILETGRAPQGKNIYYKSDLTQDITTSVLWVNSKPHMITLDYTIHV----PQAEHNNLPEVSK----------FRLSYYPHRLDNFRELLKEAFSGKMEHSVYGDFQTYVPGRSQPPCYFIHVCKK 293
BLAST of Glycine N-methyltransferase vs. Planmine SMEST
Match: SMESG000037719.1 (SMESG000037719.1) HSP 1 Score: 451.825 bits (1161), Expect = 2.752e-161 Identity = 231/232 (99.57%), Postives = 232/232 (100.00%), Query Frame = 3 Query: 90 MTATQAENSVSSKNFTNQDIMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEAXXXXXXXXXXXXXXPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKIK 785 MTATQAENSVSSKNFTNQDIMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEANWLTLQQDLNNLNNPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKK+K Sbjct: 1 MTATQAENSVSSKNFTNQDIMVDRIYRTRSLGVAVSGLPDQYADGKAAKVWELYLGSKQERTSIYKEWFINLLKNHNVTNVLDVACGTGVDSVMLLEEGFNVISTDASDKMLKVALKERWNRRHEKYFDQWVIEEANWLTLQQDLNNLNNPKVIPTNGFDAVICLGNSFAHLPDLIGDQSEQQVALANMRELLRPDGILVIDHRNYDYILKTGQAPKGKNVYYPSDHIKKLK 232 The following BLAST results are available for this feature:
BLAST of Glycine N-methyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Glycine N-methyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Glycine N-methyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Glycine N-methyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Glycine N-methyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Glycine N-methyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003448 ID=SMED30003448|Name=Glycine N-methyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=1103bpback to top protein sequence of SMED30003448-orf-1 >SMED30003448-orf-1 ID=SMED30003448-orf-1|Name=SMED30003448-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=331bp MTATQAENSVSSKNFTNQDIMVDRIYRTRSLGVAVSGLPDQYADGKAAKVback to top Annotated Terms
The following terms have been associated with this transcript:
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