Eukaryotic translation initiation factor 2-alpha kinase 1
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003352 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Human
Match: EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:HGNC Symbol;Acc:HGNC:24921]) HSP 1 Score: 165.236 bits (417), Expect = 4.979e-43 Identity = 139/478 (29.08%), Postives = 218/478 (45.61%), Query Frame = 2 Query: 335 ISFVQNFK--PIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE-------RFEEAN--------WNSQVENFTNCS----GSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNV-----PKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRC----------LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI----------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKES 1630 IS +Q + + + + ++ +N+F+ + +GKGG+GRVY NK+D Q YAIK+++I + + ++E ++LA L H NIV YHT W E R + A + Q E+ C S ++SI I + S + + N +V TN +G L S ++ Q + ++ I E SH E + E NVN + L+IQM+ C L+L DW+ RNK D E C + ++L++GV YIH+ ++HRD+KP NIFL H D Q+KIGDFGL+ C +I + R T+ GT Y++PE G YD KSD+YS+G++LLEL F T+ E V+ + G + L + P++ +++++L RP A +L Q+ F+ S Sbjct: 143 ISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGA--TKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSI--IFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELE------STLELQENGLAGLSASSIVEQQLPLRR-----NSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVD----ESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--H-GPDQQVKIGDFGLA-------CTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGS----EYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLL-QSELFQNS 586
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Human
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687]) HSP 1 Score: 124.02 bits (310), Expect = 1.281e-28 Identity = 131/477 (27.46%), Postives = 207/477 (43.40%), Query Frame = 2 Query: 296 GDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA--------NWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGS---------LSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVP-KMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKE-VRC--LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSK---FFEFDK------CDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMV-KFSTQSELCHVVEDISKGIGFKDLIETWPLED----QHVRN------LISNKPENRPEASFIL 1603 G +++ N + F + QF ++ +F+ ++ +GKG FG V NK+D YA+K++ IN + + I E +L++L+H NIVRY+ W ER E + ++ G A+ + + + S S +G +S A GS ++ +S + +S+ S+IIF+ N +S + + ED C S +V + LYIQME+C ++ L T+ +++ VR L R++L G+ YIH +IHRD+KP NIFL D +KIGDFGL+ F D D I S LT GTA Y +PEV G K +Y+ K DL+S+G+I E+ T SE V+ + K +P ED +H + L+++ P RP A+ +L Sbjct: 557 GQDYVETVIPSNRLPSAAFFSETQRQF--SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKG---EVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS-ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSE-----SDIIFD-----NEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYC---------EKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL----DSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEV-QGSTKS-AYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPK-----FP-EDFDDGEHAKQKSVISWLLNHDPAKRPTATELL 996
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Human
Match: EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255]) HSP 1 Score: 115.161 bits (287), Expect = 5.560e-26 Identity = 70/199 (35.18%), Postives = 112/199 (56.28%), Query Frame = 2 Query: 1013 LYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKM----KLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDL-IETWPLEDQHVRNLISNKPENRPEA 1591 LYIQM+ C NL+DW+ R T+++ + + Q+ + VE++HS ++HRD+KP+NIF + D +K+GDFGL + D+ +E + + M + T GT Y +PE +G SY HK D++S+G+IL EL+ FSTQ E + D+ + + F L + +P E V++++S P RPEA Sbjct: 884 LYIQMQLCRKENLKDWMNGR----CTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTM----DDVVKVGDFGLVTAMDQDE-EEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGN----SYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDV-RNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEA 1068 HSP 2 Score: 66.2402 bits (160), Expect = 1.288e-10 Identity = 34/96 (35.42%), Postives = 57/96 (59.38%), Query Frame = 2 Query: 362 IKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVE 649 IK +++ + DF+ I+ +G+GGFG V+ A NK+D YAIK++ + +L +++ ++E + LAKL H IVRY W E E W +++ Sbjct: 580 IKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV---MREVKALAKLEHPGIVRYFNAWLEAPPE-KWQEKMD 671
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Human
Match: EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437]) HSP 1 Score: 103.99 bits (258), Expect = 7.006e-23 Identity = 77/213 (36.15%), Postives = 108/213 (50.70%), Query Frame = 2 Query: 1013 LYIQMEFCHLN-LQDWLCNRN--KLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQN 1642 L+IQMEFC L+ W+ R KL L F+ Q+ KGV+YIHS +IHRD+KP+NIFL+ Q+KIGDFGL + D K T + GT Y +PE + + Y + DLY++G+IL EL+ T E D+ GI D+ + E ++ L+S KPE+RP S IL +K+S +N Sbjct: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE-------QITKGVDYIHSKKLIHRDLKPSNIFLV----DTKQVKIGDFGLVTSLKNDG----------KRTRSKGTLRYMSPEQISSQ----DYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI-ISDIFDKK--EKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKN 505
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Human
Match: EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437]) HSP 1 Score: 103.99 bits (258), Expect = 8.454e-23 Identity = 77/214 (35.98%), Postives = 111/214 (51.87%), Query Frame = 2 Query: 1013 LYIQMEFCHLN-LQDWLCNRN--KLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIR-KMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQN 1642 L+IQMEFC L+ W+ R KL L F+ Q+ KGV+YIHS +IHRD+KP+NIFL+ Q+KIGDFGL ++S++ K T + GT Y +PE + + Y + DLY++G+IL EL+ T E D+ GI D+ + E ++ L+S KPE+RP S IL +K+S +N Sbjct: 362 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE-------QITKGVDYIHSKKLIHRDLKPSNIFLV----DTKQVKIGDFGL-----------VTSLKNDGKRTRSKGTLRYMSPEQISSQ----DYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI-ISDIFDKK--EKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKN 546 HSP 2 Score: 58.5362 bits (140), Expect = 2.691e-8 Identity = 32/70 (45.71%), Postives = 43/70 (61.43%), Query Frame = 2 Query: 398 DFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVW 607 DF I+ IG GGFG+V+ A ++ID + Y IK+V N NEK +E + LAKL+H NIV Y+ W Sbjct: 266 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN----NEK----AEREVKALAKLDHVNIVHYNGCW 327
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Celegans
Match: pek-1 (Eukaryotic translation initiation factor 2-alpha kinase pek-1 [Source:UniProtKB/Swiss-Prot;Acc:Q19192]) HSP 1 Score: 101.679 bits (252), Expect = 4.485e-22 Identity = 67/199 (33.67%), Postives = 102/199 (51.26%), Query Frame = 2 Query: 1013 LYIQMEFC-HLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQ-LKIGDFGLSKFFEFDKCDEIS----SIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEA 1591 LYI M+ C L+DW+ R+K T++ ++ +QL G+EY+H+ IHRD+KP N+F + + Q LKIGD GL+ + D +I+ S K T N GT Y +PE + K Y K D++++G++ EL++ FST SE H D KG +++ P + L S +P RP A Sbjct: 880 LYIVMQLCAEKTLEDWI-RRSK---TMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLAT--KTDGAPKITVRQDSDSSAKHTKNVGTRSYMSPE----QLKHQQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKG-DIPAILDNVPESRDFLLQLTSLEPSERPTA 1067 HSP 2 Score: 54.299 bits (129), Expect = 2.696e-7 Identity = 30/92 (32.61%), Postives = 47/92 (51.09%), Query Frame = 2 Query: 380 VNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENF 655 ++ N+F+ K IG GGFG V+ A + D YA+K++ + N+K ++E R LA +H I+RY W ER + + EN Sbjct: 597 TSRFANEFEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVAD---NDKARNRVLREARALAMFDHPGIIRYFYAWEERPPKGFQEKEDENL 685
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Celegans
Match: Y38E10A.8 (pep chromosome:WBcel235:II:12607200:12608788:1 gene:WBGene00012586.1 transcript:Y38E10A.8.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y38E10A.8) HSP 1 Score: 77.411 bits (189), Expect = 2.170e-15 Identity = 61/205 (29.76%), Postives = 96/205 (46.83%), Query Frame = 2 Query: 1013 LYIQMEFCHLN-LQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKL-----------TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEA 1591 +YI ME C N L+DW+ K T + + ++ +QL ++++HSNN IHRD+KP N+F S+ +LKIGDFGL+ I ++ K TA GT Y APE R Y+ K D++++G+I EL++ + E+ DI + + + +P + + L P RP A Sbjct: 94 MYICMELCEQNTLKDWI----KGNRTARSRPWMLMKDWIKQLACALDHLHSNNFIHRDLKPENVFF-ARDSQFKKLKIGDFGLT-------TRAIEGLKDWKQRTQSQEAGQNHTAGAGTPSYMAPEQI-----RNQYNEKVDIFALGLIAAELIIINTPSDEMG--TNDIIRSGQWPIAWQDYPDAIEFLSQLTHMNPTMRPSA 279
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Celegans
Match: wee-1.3 (Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 [Source:UniProtKB/Swiss-Prot;Acc:O18209]) HSP 1 Score: 76.6406 bits (187), Expect = 2.449e-14 Identity = 51/150 (34.00%), Postives = 75/150 (50.00%), Query Frame = 2 Query: 1013 LYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQS 1462 LYIQ E C +L + ++ L E+ + LL+ V ++HSN++IH DIKP NIFL +KD+ K+GDFGL +++ S A G + Y APEV NG+ + SD++S+GM +LE S Sbjct: 179 LYIQTELCDQSLLKYCTEKHALPE-------DEIWNIFVDLLQAVHHLHSNDMIHDDIKPENIFL----TKDMICKLGDFGL--VINLKNPNDVKS-------AEEGDSKYLAPEVLNGRPTK-----SSDIFSLGMTILEATTDLDVPS 303
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099]) HSP 1 Score: 76.2554 bits (186), Expect = 3.129e-14 Identity = 60/210 (28.57%), Postives = 97/210 (46.19%), Query Frame = 2 Query: 1013 LYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSEL-------------CHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFIL 1603 L+I ME+ L KL D + + R++LKG+EY+HS IHRDIK AN+ + H +K+ DFG+ +++ K ++T G+ F+ APE+ K+ SYD+K+D++S+G+ +EL S+L V++ FK+ +E ++ PENRP AS +L Sbjct: 90 LWIIMEYLGGGSALDLTKSGKL-------DESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEH----GDVKVADFGV--------AGQLTETVKKRITF-VGSPFWMAPELI----KQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEM----------CLNKDPENRPSASTLL 265
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099]) HSP 1 Score: 76.2554 bits (186), Expect = 3.138e-14 Identity = 60/210 (28.57%), Postives = 97/210 (46.19%), Query Frame = 2 Query: 1013 LYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSEL-------------CHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFIL 1603 L+I ME+ L KL D + + R++LKG+EY+HS IHRDIK AN+ + H +K+ DFG+ +++ K ++T G+ F+ APE+ K+ SYD+K+D++S+G+ +EL S+L V++ FK+ +E ++ PENRP AS +L Sbjct: 105 LWIIMEYLGGGSALDLTKSGKL-------DESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEH----GDVKVADFGV--------AGQLTETVKKRITF-VGSPFWMAPELI----KQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEM----------CLNKDPENRPSASTLL 280
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Fly
Match: PEK (gene:FBgn0037327 transcript:FBtr0330027) HSP 1 Score: 111.309 bits (277), Expect = 5.530e-25 Identity = 69/206 (33.50%), Postives = 105/206 (50.97%), Query Frame = 2 Query: 1013 LYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFE-----FDKCDEISSIRK-MKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQ 1609 LYIQM+ C +L+DWL + D + Q++ V+Y+H +IHRD+KP+NIF S+D Q+KIGDFGL KC + S + + T GT Y +PE G+ YD+K D+YS+G+I EL V FST+ E + + G KD +P + ++ ++S +PE RP+ + +Q Sbjct: 866 LYIQMQLCRKESLRDWLRDNRSETRAAHIGD------IFHQIVDAVDYVHLKGLIHRDLKPSNIFF----SQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQ----HYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQ 1057 HSP 2 Score: 60.077 bits (144), Expect = 5.688e-9 Identity = 39/141 (27.66%), Postives = 72/141 (51.06%), Query Frame = 2 Query: 191 FYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE 613 + VI+ +V + + E T+ L+ V ++ G+ F P N + ++ + ++ +DF+ ++ +G+GGFG V+ A NK+D YAIK++ + + + + + ++E R LA H NIVRY W E Sbjct: 511 YLVIERHVPVQTAIEATEASTQALLGPVVPMQRP-GNRFSFPPGQANQRTISESTTHSGEHY-TSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRV---LREARTLASCEHHNIVRYFHSWTE 646
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Fly
Match: PEK (gene:FBgn0037327 transcript:FBtr0078770) HSP 1 Score: 110.923 bits (276), Expect = 7.247e-25 Identity = 69/206 (33.50%), Postives = 105/206 (50.97%), Query Frame = 2 Query: 1013 LYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFE-----FDKCDEISSIRK-MKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQ 1609 LYIQM+ C +L+DWL + D + Q++ V+Y+H +IHRD+KP+NIF S+D Q+KIGDFGL KC + S + + T GT Y +PE G+ YD+K D+YS+G+I EL V FST+ E + + G KD +P + ++ ++S +PE RP+ + +Q Sbjct: 929 LYIQMQLCRKESLRDWLRDNRSETRAAHIGD------IFHQIVDAVDYVHLKGLIHRDLKPSNIFF----SQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQ----HYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQ 1120 HSP 2 Score: 60.077 bits (144), Expect = 5.342e-9 Identity = 39/141 (27.66%), Postives = 72/141 (51.06%), Query Frame = 2 Query: 191 FYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE 613 + VI+ +V + + E T+ L+ V ++ G+ F P N + ++ + ++ +DF+ ++ +G+GGFG V+ A NK+D YAIK++ + + + + + ++E R LA H NIVRY W E Sbjct: 574 YLVIERHVPVQTAIEATEASTQALLGPVVPMQRP-GNRFSFPPGQANQRTISESTTHSGEHY-TSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRV---LREARTLASCEHHNIVRYFHSWTE 709
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Fly
Match: PEK (gene:FBgn0037327 transcript:FBtr0330026) HSP 1 Score: 110.923 bits (276), Expect = 7.374e-25 Identity = 69/206 (33.50%), Postives = 105/206 (50.97%), Query Frame = 2 Query: 1013 LYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFE-----FDKCDEISSIRK-MKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQ 1609 LYIQM+ C +L+DWL + D + Q++ V+Y+H +IHRD+KP+NIF S+D Q+KIGDFGL KC + S + + T GT Y +PE G+ YD+K D+YS+G+I EL V FST+ E + + G KD +P + ++ ++S +PE RP+ + +Q Sbjct: 877 LYIQMQLCRKESLRDWLRDNRSETRAAHIGD------IFHQIVDAVDYVHLKGLIHRDLKPSNIFF----SQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQ----HYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQ 1068 HSP 2 Score: 60.077 bits (144), Expect = 5.558e-9 Identity = 39/141 (27.66%), Postives = 72/141 (51.06%), Query Frame = 2 Query: 191 FYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE 613 + VI+ +V + + E T+ L+ V ++ G+ F P N + ++ + ++ +DF+ ++ +G+GGFG V+ A NK+D YAIK++ + + + + + ++E R LA H NIVRY W E Sbjct: 522 YLVIERHVPVQTAIEATEASTQALLGPVVPMQRP-GNRFSFPPGQANQRTISESTTHSGEHY-TSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRV---LREARTLASCEHHNIVRYFHSWTE 657
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Fly
Match: Gcn2 (gene:FBgn0019990 transcript:FBtr0334552) HSP 1 Score: 83.5741 bits (205), Expect = 3.038e-16 Identity = 75/262 (28.63%), Postives = 118/262 (45.04%), Query Frame = 2 Query: 980 SNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS--KFFEFDKCD-------EISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL-MVKFSTQSELCHVVEDISK-GIGFKDLIETWPLEDQHVRN---LISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTL 1723 +N P M+ +YIQMEFC C + +D + L R++ +G+ +IH +IHRD+KP NIFL H Q+KIGDFGL+ F D +I+S T GT Y APE G + Y+ K D+Y++G+IL E+ F T E + + I D + P ++ V+ L+++ P RP A +L + N L ++ ++ N + K+ L+ + L Sbjct: 686 TNSPKPLMQ-VMYIQMEFCEK------CTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD----QIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALA-NPQSKAYKNLVARCL 934 HSP 2 Score: 55.8398 bits (133), Expect = 1.143e-7 Identity = 31/106 (29.25%), Postives = 55/106 (51.89%), Query Frame = 2 Query: 314 PNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEAN 631 PN +Q + S + P ++L +F+ + +GKG FG V N +D + YAIK++ + + + +E +L++LNH N+VRY W E ++A+ Sbjct: 497 PNTVQRTGSAMPYQIPT-LALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPAR--SRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDAD 599
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Fly
Match: Gcn2 (gene:FBgn0019990 transcript:FBtr0334551) HSP 1 Score: 83.5741 bits (205), Expect = 3.090e-16 Identity = 75/262 (28.63%), Postives = 118/262 (45.04%), Query Frame = 2 Query: 980 SNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS--KFFEFDKCD-------EISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL-MVKFSTQSELCHVVEDISK-GIGFKDLIETWPLEDQHVRN---LISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTL 1723 +N P M+ +YIQMEFC C + +D + L R++ +G+ +IH +IHRD+KP NIFL H Q+KIGDFGL+ F D +I+S T GT Y APE G + Y+ K D+Y++G+IL E+ F T E + + I D + P ++ V+ L+++ P RP A +L + N L ++ ++ N + K+ L+ + L Sbjct: 684 TNSPKPLMQ-VMYIQMEFCEK------CTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD----QIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALA-NPQSKAYKNLVARCL 932 HSP 2 Score: 55.8398 bits (133), Expect = 1.183e-7 Identity = 31/106 (29.25%), Postives = 55/106 (51.89%), Query Frame = 2 Query: 314 PNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEAN 631 PN +Q + S + P ++L +F+ + +GKG FG V N +D + YAIK++ + + + +E +L++LNH N+VRY W E ++A+ Sbjct: 495 PNTVQRTGSAMPYQIPT-LALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPAR--SRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDAD 597
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Zebrafish
Match: BX072573.1 (eukaryotic translation initiation factor 2-alpha kinase 3 [Source:NCBI gene;Acc:559564]) HSP 1 Score: 139.428 bits (350), Expect = 5.916e-34 Identity = 133/514 (25.88%), Postives = 223/514 (43.39%), Query Frame = 2 Query: 287 KCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYAN---SIP---KIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQ-------------------------NSDCRHSGSNIIFEYSSNFNHKHDSLTSHS----------SEDKGALEICKSSNVNVPKMEFALYIQME--------------FCHLNLQDWLCNRNKLVSTLQDSDFKEVR----CLA--RQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCD-EISSIRKMKL----TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFK-DLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKE 1627 +C D + + V + +P ++ V++ + DF+ ++ +G+GGFG V+ A NK+D YAIK++ + +L +++ ++E + LAKL H I+RY W E + W ++ S A+ S P + S + S+ M G + S + G S+ S D+Q + DC S +I+FE S + +DS S S S K +++P L + + ++ +Q LC + L + E+R CL Q+ + V+++HS ++HRD+KP+NIF + D +K+GDFGL + ++ D E+S++ M + T GT Y +PE +G SY HK D+YS+G+IL EL+ F TQ E + ++ + + F + LE Q VR ++S P RPEAS I + F+E Sbjct: 577 QCQTDTKFEADVTEPKEVVVTDMRPCEY---VSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKV---MREVKALAKLEHPGIIRYFNAWQESPPQG-WQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDSSCMCAAGGDTSVCVGDQVCVEGLGPDSMM--SERDSQADPDAIMEVSDSPHSFELCPPRTVAHGDCTSSSFDIVFEDSGCEHQDNDSDLSGSTPVPPVCLSQSGSKPQRSTSTGPPISLPSRPTTLSLAPSTPCPAVRPLLTPKVYLYIQMQ--LCRKENLKDWMAQRCLPELREHTQCLDIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTM----DDVVKVGDFGLVTAMDQEEDDEELSTLTPMPIYARHTGQVGTKLYMSPEQLSGN----SYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEV-RALQFPAAFCKANILEAQMVRCMLSRVPAERPEASEI-TEAPLFQE 1069
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Zebrafish
Match: eif2ak3 (eukaryotic translation initiation factor 2-alpha kinase 3 [Source:ZFIN;Acc:ZDB-GENE-050414-2]) HSP 1 Score: 139.428 bits (350), Expect = 6.650e-34 Identity = 133/514 (25.88%), Postives = 223/514 (43.39%), Query Frame = 2 Query: 287 KCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYAN---SIP---KIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQ-------------------------NSDCRHSGSNIIFEYSSNFNHKHDSLTSHS----------SEDKGALEICKSSNVNVPKMEFALYIQME--------------FCHLNLQDWLCNRNKLVSTLQDSDFKEVR----CLA--RQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCD-EISSIRKMKL----TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFK-DLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKE 1627 +C D + + V + +P ++ V++ + DF+ ++ +G+GGFG V+ A NK+D YAIK++ + +L +++ ++E + LAKL H I+RY W E + W ++ S A+ S P + S + S+ M G + S + G S+ S D+Q + DC S +I+FE S + +DS S S S K +++P L + + ++ +Q LC + L + E+R CL Q+ + V+++HS ++HRD+KP+NIF + D +K+GDFGL + ++ D E+S++ M + T GT Y +PE +G SY HK D+YS+G+IL EL+ F TQ E + ++ + + F + LE Q VR ++S P RPEAS I + F+E Sbjct: 577 QCQTDTKFEADVTEPKEVVVTDMRPCEY---VSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKV---MREVKALAKLEHPGIIRYFNAWQESPPQG-WQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDSSCMCAAGGDTSVCVGDQVCVEGLGPDSMM--SERDSQADPDAIMEVSDSPHSFELCPPRTVAHGDCTSSSFDIVFEDSGCEHQDNDSDLSGSTPVPPVCLSQSGSKPQRSTSTGPPISLPSRPTTLSLAPSTPCPVVRPLLTPKVYLYIQMQ--LCRKENLKDWMAQRCLPELREHTQCLDIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTM----DDVVKVGDFGLVTAMDQEEDDEELSTLTPMPIYARHTGQVGTKLYMSPEQLSGN----SYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEV-RALQFPAAFCKANILEAQMVRCMLSRVPAERPEASEI-TEAPLFQE 1069
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Zebrafish
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268]) HSP 1 Score: 129.413 bits (324), Expect = 4.189e-31 Identity = 83/267 (31.09%), Postives = 135/267 (50.56%), Query Frame = 2 Query: 1007 FALYIQMEFCHLNLQDWLCNRNKLVS--------TLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-KFFEFDKCDEISSIRKMKL------TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENEL--LRKTLDDLRLSQQKQH 1756 LYIQM+ C +L+DW+ RN + D ++ + +++L+GVEYIHS ++HRD+KP NIFL+ + +KIGDFGL+ + D+ +++ S + + T+ GT Y+APE G YD KSD+YS+G+I EL F T+ E H + ++ +G L WP+ ++++ L S+ P RP A +L +V + L I + E E+ LR+ + +L++SQ H Sbjct: 366 LMLYIQMQLCERSLKDWIQERNSRTTEGLLMSGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKPRNIFLL---GNECHVKIGDFGLACQNIIMDEHEKLPSSSQAGVNPDATHTSGVGTFVYAAPEQLEGS----RYDSKSDMYSIGVIAFELFQPFGTEMERVHTLGELRQGKIPNTLSTNWPILAKYIKLLTSSDPSMRPSAPQLLQSDLFSTNDMVIHSLKRKIDE---------QEEEIVQLRRRISELQISQNSIH 616 HSP 2 Score: 76.6406 bits (187), Expect = 3.825e-14 Identity = 31/87 (35.63%), Postives = 55/87 (63.22%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA 628 FQ + ++ +++F+ I +GKG +G+V+ NK+D Q YA+K+++I K+ + ++E ++L+ L H NIV YHT W E + A Sbjct: 135 FQAQTSRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIK--KVTRDDCMKVLREVKVLSSLQHPNIVGYHTAWMEHVQPA 219
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Zebrafish
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268]) HSP 1 Score: 129.413 bits (324), Expect = 4.425e-31 Identity = 85/267 (31.84%), Postives = 137/267 (51.31%), Query Frame = 2 Query: 1007 FALYIQMEFCHLNLQDWLCNRNK------LVS--TLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-KFFEFDKCDEISSIRKMKL------TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENEL--LRKTLDDLRLSQQKQH 1756 LYIQM+ C +L+DW+ RN L+S D ++ + +++L+GVEYIHS ++HRD+KP NIFL+ + +KIGDFGL+ + D+ +++ S + + T+ GT Y+APE G YD KSD+YS+G+I EL F T+ E H + ++ +G L WP+ ++++ L S+ P RP A +L +V + L I + E E+ LR+ + +L++SQ H Sbjct: 366 LMLYIQMQLCERSLKDWIQERNSRTTEGLLISGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKPRNIFLL---GNECHVKIGDFGLACQNIIMDEHEKLPSSSQAGVNPDATHTSGVGTFVYAAPEQLEGS----RYDSKSDMYSIGVIAFELFQPFGTEMERVHTLGELRQGKIPNTLSTNWPILAKYIKLLTSSDPSMRPSAPQLLQSDLFSTNDMVIHSLKRKIDE---------QEEEIVQLRRRISELQISQNSIH 616 HSP 2 Score: 76.6406 bits (187), Expect = 4.137e-14 Identity = 31/87 (35.63%), Postives = 55/87 (63.22%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA 628 FQ + ++ +++F+ I +GKG +G+V+ NK+D Q YA+K+++I K+ + ++E ++L+ L H NIV YHT W E + A Sbjct: 135 FQAQTSRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIK--KVTRDDCMKVLREVKVLSSLQHPNIVGYHTAWMEHVQPA 219
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Zebrafish
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268]) HSP 1 Score: 126.331 bits (316), Expect = 6.343e-30 Identity = 81/267 (30.34%), Postives = 135/267 (50.56%), Query Frame = 2 Query: 1007 FALYIQMEFCHLNLQDWLCNRNKLVS--------TLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-KFFEFDKCDEISSIRKMKL------TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENEL--LRKTLDDLRLSQQKQH 1756 LYIQM+ C +L+DW+ RN + D ++ + +++L+GVEYIHS ++HRD+KP NIFL+ + +KIGDFGL+ + D+ +++ S + + T+ GT Y+APE G YD K+++YS+G+I EL F T+ E H + ++ +G L WP+ ++++ L S+ P RP A +L +V + L I + E E+ LR+ + +L++SQ H Sbjct: 413 LMLYIQMQLCERSLKDWIQERNSRTTEGLLMSGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKPRNIFLL---GNECHVKIGDFGLACQNIIMDEHEKLPSSSQAGVNPDATHTSGVGTFVYAAPEQLEGS----RYDSKANMYSIGVIAFELFQPFGTEMERVHTLGELRQGKIPNTLSTNWPILAKYIKLLTSSDPSMRPSAPQLLQSDLFSTNDMVIHSLKRKIDE---------QEEEIVQLRRRISELQISQNSIH 663 HSP 2 Score: 76.6406 bits (187), Expect = 4.375e-14 Identity = 31/87 (35.63%), Postives = 55/87 (63.22%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA 628 FQ + ++ +++F+ I +GKG +G+V+ NK+D Q YA+K+++I K+ + ++E ++L+ L H NIV YHT W E + A Sbjct: 182 FQAQTSRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIK--KVTRDDCMKVLREVKVLSSLQHPNIVGYHTAWMEHVQPA 266
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Xenopus
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:733794]) HSP 1 Score: 193.356 bits (490), Expect = 4.060e-53 Identity = 148/481 (30.77%), Postives = 235/481 (48.86%), Query Frame = 2 Query: 377 KVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQ----VENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSI------YDR---SNIDTQNSDCRHS--GSNIIFEYSS-NFNHKHDSLTSHSS--EDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS--KFFEFDKCDEISSIRKMKLTANT--GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLR 1735 + ++ +N+FD I +GKGG+G+VY NK+D Q YAIK+++I K++ ++ ++E ++LA L H NIV YHT W E + N + V+ F N + ++ S + S + +VS N S + H I Y + +N+ + C S ++ + F+ + D S SS E+ ++C + + + L+IQM+ C +L DW+ RN +S DF +VR R Q+L+GV YIHS V+HRD+KP N+FL D+ ++IGDFGL+ F+ + + R LT T GT Y+APE G YD KSD+YS+G+ILLEL F T+ E V+ + G WP++ V+ L S++ RP AS +L ES + + N ++D+ + L+ ENE L+++L L+ Sbjct: 158 QTSRYLNEFDEIAQLGKGGYGKVYKVRNKLDGQFYAIKKILIK--KVSRRDCRKVLREVKVLAGLQHPNIVGYHTAWMEHVQPPNSQCKLLKAVKGFPNNKAE--QDMKEVRSVESSGSFIMFEDSAHQDPSAQSVSESVNMSVSSPDKPDHCIENAGNNYKKDSNANVAKKTKACSKSYQSQGLVCQRDKCPFSSEDDVDKSDSSCDEECPQKDLCLHRHFEI-QYHLMLHIQMKLCEKSLWDWIVERNNHFQESGNSNPYDFVDVRITTRILYQILEGVRYIHSMEVLHRDLKPRNVFL---HGADLHVRIGDFGLACRDIFQQSRDSWLQKDRSNGLTHTTGVGTCLYAAPEQLKGS----HYDFKSDMYSIGIILLELFQPFGTEMERTQVLTALRNGTVPCSYERQWPVQSNFVKLLTSSECSERPSASQML-------ESQLFHQKENLVQDLQKKVLYLEEENERLKRSLQKLQ 619
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Xenopus
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:733794]) HSP 1 Score: 161.384 bits (407), Expect = 7.571e-42 Identity = 138/481 (28.69%), Postives = 217/481 (45.11%), Query Frame = 2 Query: 377 KVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQ----VENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSI------YDR---SNIDTQNSDCRHS--GSNIIFEYSS-NFNHKHDSLTSHSS--EDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS--KFFEFDKCDEISSIRKMKLTANT--GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLR 1735 + ++ +N+FD I +GKGG+G+VY ++E ++LA L H NIV YHT W E + N + V+ F N + ++ S + S + +VS N S + H I Y + +N+ + C S ++ + F+ + D S SS E+ ++C + + + L+IQM+ C +L DW+ RN +S DF +VR R Q+L+GV YIHS V+HRD+KP N+FL D+ ++IGDFGL+ F+ + + R LT T GT Y+APE G YD KSD+YS+G+ILLEL F T+ E V+ + G WP++ V+ L S++ RP AS +L ES + + N ++D+ + L+ ENE L+++L L+ Sbjct: 158 QTSRYLNEFDEIAQLGKGGYGKVYK-----------------------------VLREVKVLAGLQHPNIVGYHTAWMEHVQPPNSQCKLLKAVKGFPNNKAE--QDMKEVRSVESSGSFIMFEDSAHQDPSAQSVSESVNMSVSSPDKPDHCIENAGNNYKKDSNANVAKKTKACSKSYQSQGLVCQRDKCPFSSEDDVDKSDSSCDEECPQKDLCLHRHFEI-QYHLMLHIQMKLCEKSLWDWIVERNNHFQESGNSNPYDFVDVRITTRILYQILEGVRYIHSMEVLHRDLKPRNVFLH---GADLHVRIGDFGLACRDIFQQSRDSWLQKDRSNGLTHTTGVGTCLYAAPEQLKGS----HYDFKSDMYSIGIILLELFQPFGTEMERTQVLTALRNGTVPCSYERQWPVQSNFVKLLTSSECSERPSASQML-------ESQLFHQKENLVQDLQKKVLYLEEENERLKRSLQKLQ 592
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297]) HSP 1 Score: 152.91 bits (385), Expect = 2.557e-38 Identity = 135/489 (27.61%), Postives = 226/489 (46.22%), Query Frame = 2 Query: 380 VNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRH-------------------SGSNIIFEYSS---NFNH----------------KHDSLTSHSSEDKGA----------------LEICKSSNVNVPKMEFALY--IQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKM----KLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLI-ETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHI 1660 V++ + DF+ I+ +G+GGFG V+ A NK+D YAIK++ + +L +++ ++E + LAKL H IVRY W E E W +++ GS + + + + SM V +T + +++ SLS + I + D H + S+I+FE S + NH + +S T S+E K L++ K++ ++ +Y IQM+ C NL+DW+ R TL++ E + Q+ + V+++HS ++HRD+KP+NIF + D +K+GDFGL + ++ DE + + M + T GT Y +PE G+ SY HK D++S+G+IL EL+ FSTQ E V+ ++ + + F L E + E V ++IS+ P RPEA E I++N L++ I Sbjct: 399 VSRYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKV---MREVKALAKLEHPGIVRYFNAWLEAPPEL-WQEKMDELLLKDGSTDWPLSSPTPLDGLSVKVRSVDPYSMK---EQVEVITPSESYS--SLSAAFVAVPGIGDSDDDDNHGIWYEHCPRTAADIGVHERTSSSIVFEDSGCDNSSNHVDKAEVSVLVMNSEFSERESGTKDSNESKPTSISTLSESPPRPKSLCLDLSKNTAESIKPTSPKVYLYIQMQLCRKENLKDWMSAR----CTLEERPQTESLHVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTL----DDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARHTGQVGTKLYMSPEQIFGQ----SYSHKVDIFSLGLILFELLYPFSTQMERVRVLTEL-RDLKFPQLFTERYSTEQNMVLHMISHNPNERPEA-----------EEIIENPLFDSI 853
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297]) HSP 1 Score: 148.673 bits (374), Expect = 6.621e-37 Identity = 134/489 (27.40%), Postives = 226/489 (46.22%), Query Frame = 2 Query: 380 VNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRH-------------------SGSNIIFEYSS---NFNH----------------KHDSLTSHSSEDKGA----------------LEICKSSNVNVPKMEFALY--IQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKM----KLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLI-ETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHI 1660 V++ + DF+ I+ +G+GGFG V+ A NK+D YAIK++ + +L +++ ++E + LAKL H IVRY W E E W +++ GS + + + + SM V +T + +++ SLS + I + D H + S+I+FE S + NH + +S T S+E K L++ K++ ++ +Y IQM+ C NL+DW+ R TL++ E + Q+ + V+++HS ++HRD+KP+NIF + D +K+GDFGL + ++ DE + + M + T GT Y +PE G+ SY HK D++S+G+IL EL+ FSTQ E V+ ++ + + F L+ L+ V ++IS+ P RPEA E I++N L++ I Sbjct: 397 VSRYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKV---MREVKALAKLEHPGIVRYFNAWLEAPPEL-WQEKMDELLLKDGSTDWPLSSPTPLDGLSVKVRSVDPYSMK---EQVEVITPSESYS--SLSAAFVAVPGIGDSDDDDNHGIWYEHCPRTAADIGVHERTSSSIVFEDSGCDNSSNHVDKAEVSVLVMNSEFSERESGTKDSNESKPTSISTLSESPPRPKSLCLDLSKNTAESIKPTSPKVYLYIQMQLCRKENLKDWMSAR----CTLEERPQTESLHVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTL----DDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARHTGQVGTKLYMSPEQIFGQ----SYSHKVDIFSLGLILFELLYPFSTQMERVRVLTEL-RDLKFPQLLFLCLYLQQNMVLHMISHNPNERPEA-----------EEIIENPLFDSI 851
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Xenopus
Match: eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:NCBI gene;Acc:100216307]) HSP 1 Score: 134.035 bits (336), Expect = 5.670e-32 Identity = 139/455 (30.55%), Postives = 205/455 (45.05%), Query Frame = 2 Query: 362 IKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSY-----------------ANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDS-LTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS-------DFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGL----------SKFFEFDKC--DEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVK-FSTQSELCHVVEDISKG-IGFKDLIETWPLEDQH--VRNLISNKPENRPEASFIL 1603 I+ Q + ++ N+F+ ++ +GKG FG V NK+D YA+K+V IN + K+ E +L++LNH NIVRY+ W E+ E + + E + N+ I SS + S S++ NG SS ++ G S S ++ D S IIFE + + D ++ ED+ A +N V + LYIQME+C STL+D+ D + L R++L G+ YIH +IHRD+KP NIFL S+D +KIGDFGL S E D+ D + + KLT GTA Y +PEV G K SY+ K DLYS+G+IL E+ + T SE V+ + + I F E E Q + L+++ P +RP A +L Sbjct: 594 IESQRQFSRYFNEFEELQMLGKGAFGAVIKVQNKLDGCYYAVKRVQINPAS---KQFRRIKGEVTLLSRLNHENIVRYYNAWIEKHEHPTISPKCEAHEEKKVTVKPEQIVKNDLGLLDDIEENAPAPILTSSVEWSTSCERSSSAHCTNGDQDSSDDDDDDDEEGVFSPSFLPGTDSD----------SEIIFENEDDISPDQDEEYDKNNVEDRKA-----GANEIVTQAVHYLYIQMEYCE-------------KSTLRDTIDQGLYMDVGRLWRLFREILDGLTYIHEQGMIHRDLKPVNIFL---DSED-HVKIGDFGLATDHPASYTESAQGEEDQAHSDLVKVDPEGKLTGMVGTALYVSPEV-QGNTK-ASYNQKVDLYSLGIILFEMSYRPMDTSSERISVLSRLRQALIVFPSDFENPENEKQKKVITWLLNHDPASRPTAMELL 1011
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Mouse
Match: Eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:MGI Symbol;Acc:MGI:1353448]) HSP 1 Score: 170.629 bits (431), Expect = 3.283e-45 Identity = 133/449 (29.62%), Postives = 209/449 (46.55%), Query Frame = 2 Query: 338 SFVQNFKP--IKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQV-------ENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSL--SHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHD---SLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRC----------LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLT--ANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILN 1606 S++Q + I F+ + ++ +N+F+ + +GKGG+GRVY NK+D Q YAIK+++I + + + ++E ++LA L H NIV YHT W E +V E + G K + SSS + + F S V + NN T +L +S S+I+ Q + + H + + TS +G L + + V + L+IQM+ C L+L DW+ RNK D E C + ++L++GV YIH+ ++HRD+KP NIFL D Q+KIGDFGL+ D + K T + GT Y++PE G YD KSD+YS+G+ILLEL F T+ E V+ + G + L + P++ ++++ L RP A +L Sbjct: 144 SYMQKIRSREIAFEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSA--TKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGHSSELEGNFTSTDESSEGNLNLLGQTEV---RYHLMLHIQMQLCELSLWDWITERNKRSREYVD----EAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL---HGPDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGS----QYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQ 576
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427]) HSP 1 Score: 126.716 bits (317), Expect = 8.562e-30 Identity = 127/418 (30.38%), Postives = 189/418 (45.22%), Query Frame = 2 Query: 296 GDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA--------NWNSQVENF----------TNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSF--NGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSED----KGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS----KFFEFDKCDE------ISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL 1438 G ++I N + F + QF ++ +F+ ++ +GKG FG V NK+D YA+K++ IN + + + I E +L++L+H NIVRY+ W ER E + Q ++ T GS + P SSS ++S STS F G + SS + G S S S+ D S+IIF+ N +S + + ED G+ EI +V + + LYIQME+C ++ L T+ F++ L R ++L G+ YIH +IHRD+KP NIFL D +KIGDFGL+ F K D+ I S LT GTA Y +PEV G K +Y+ K DL+S+G+I E+ Sbjct: 278 GQDYIETVIPSNQLPSAAFFSETQKQF--SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKG---EVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAAAPPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEEDEDERDGVFSQSFLPASDSD----------SDIIFD-----NEDENSKSQNQDEDCNQKDGSHEI--EPSVTAEAVHY-LYIQMEYC---------EKSTLRDTIDQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL----DSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEV-QGSTKS-AYNQKVDLFSLGIIFFEM 657
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427]) HSP 1 Score: 126.716 bits (317), Expect = 9.343e-30 Identity = 127/418 (30.38%), Postives = 189/418 (45.22%), Query Frame = 2 Query: 296 GDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA--------NWNSQVENF----------TNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSF--NGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSED----KGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS----KFFEFDKCDE------ISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL 1438 G ++I N + F + QF ++ +F+ ++ +GKG FG V NK+D YA+K++ IN + + + I E +L++L+H NIVRY+ W ER E + Q ++ T GS + P SSS ++S STS F G + SS + G S S S+ D S+IIF+ N +S + + ED G+ EI +V + + LYIQME+C ++ L T+ F++ L R ++L G+ YIH +IHRD+KP NIFL D +KIGDFGL+ F K D+ I S LT GTA Y +PEV G K +Y+ K DL+S+G+I E+ Sbjct: 478 GQDYIETVIPSNQLPSAAFFSETQKQF--SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKG---EVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAAAPPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEEDEDERDGVFSQSFLPASDSD----------SDIIFD-----NEDENSKSQNQDEDCNQKDGSHEI--EPSVTAEAVHY-LYIQMEYC---------EKSTLRDTIDQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL----DSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEV-QGSTKS-AYNQKVDLFSLGIIFFEM 857
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427]) HSP 1 Score: 126.716 bits (317), Expect = 9.521e-30 Identity = 125/414 (30.19%), Postives = 189/414 (45.65%), Query Frame = 2 Query: 296 GDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA--------NWNSQVENF----------TNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSF--NGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS----KFFEFDKCDE------ISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL 1438 G ++I N + F + QF ++ +F+ ++ +GKG FG V NK+D YA+K++ IN + + + I E +L++L+H NIVRY+ W ER E + Q ++ T GS + P SSS ++S STS F G + SS + G S S S+ D S+IIF+ + + N K + ++ G+ EI +V + + LYIQME+C ++ L T+ F++ L R ++L G+ YIH +IHRD+KP NIFL D +KIGDFGL+ F K D+ I S LT GTA Y +PEV G K +Y+ K DL+S+G+I E+ Sbjct: 556 GQDYIETVIPSNQLPSAAFFSETQKQF--SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKG---EVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAAAPPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEEDEDERDGVFSQSFLPASDSD----------SDIIFD-NEDENSKSQNQDEDCNQKDGSHEI--EPSVTAEAVHY-LYIQMEYC---------EKSTLRDTIDQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL----DSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEV-QGSTKS-AYNQKVDLFSLGIIFFEM 935
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427]) HSP 1 Score: 126.716 bits (317), Expect = 9.831e-30 Identity = 127/418 (30.38%), Postives = 189/418 (45.22%), Query Frame = 2 Query: 296 GDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA--------NWNSQVENF----------TNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSF--NGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSED----KGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS----KFFEFDKCDE------ISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL 1438 G ++I N + F + QF ++ +F+ ++ +GKG FG V NK+D YA+K++ IN + + + I E +L++L+H NIVRY+ W ER E + Q ++ T GS + P SSS ++S STS F G + SS + G S S S+ D S+IIF+ N +S + + ED G+ EI +V + + LYIQME+C ++ L T+ F++ L R ++L G+ YIH +IHRD+KP NIFL D +KIGDFGL+ F K D+ I S LT GTA Y +PEV G K +Y+ K DL+S+G+I E+ Sbjct: 435 GQDYIETVIPSNQLPSAAFFSETQKQF--SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKG---EVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAAAPPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEEDEDERDGVFSQSFLPASDSD----------SDIIFD-----NEDENSKSQNQDEDCNQKDGSHEI--EPSVTAEAVHY-LYIQMEYC---------EKSTLRDTIDQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFL----DSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEV-QGSTKS-AYNQKVDLFSLGIIFFEM 814
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. UniProt/SwissProt
Match: sp|Q4R8E0|E2AK1_MACFA (Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Macaca fascicularis OX=9541 GN=EIF2AK1 PE=2 SV=1) HSP 1 Score: 171.4 bits (433), Expect = 1.647e-44 Identity = 142/489 (29.04%), Postives = 219/489 (44.79%), Query Frame = 2 Query: 335 ISFVQNFK--PIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERF-----------------------EEANWNSQVENFTNCSGS--YANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSL--SHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNF---NHKHDSLTSHSSEDKGALEICKSSNVNV-----PKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRC----------LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI----------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKES 1630 +S +Q + + F+ + ++ +N+F+ + +GKGG+GRVY NK+D Q YAIK+++I + + + ++E ++LA L H NIV YHT W E EE V+N + S S +A P+ F S+ + + S T SL S S ++ Q +D ++ I E +H DS TS E NVN + L+IQM+ C L+L DW+ RNK D E C + ++L++GV YIH+ ++HRD+KP NIFL H D Q+KIGDFGL+ C +I + R T+ GT Y++PE G YD KSD+YS+G+ILLEL F T+ E V+ + G + L + P++ +++++L RP A +L Q+ F+ S Sbjct: 143 VSHIQKIRSREVAFEAQTSRYLNEFEEVAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGA--TKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPTLEVLSDQEEDREQYDVKNDESSSSSIVFAEPTPE----------------KGKRFGESDTENQNDKSVKYTTSLVIRDSGELESTLELQENDLAGLSTSSIMEQQLPLRRNSHLDDSFTS--------TEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIAERNKRSRECVD----ESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--H-GPDQQVKIGDFGLA-------CTDILQKNADWTNRNGKRTPTHTSRVGTCLYASPEQLEGS----EYDAKSDMYSLGVILLELFQPFGTEMERAEVLTGLRTGQLPESLSKRCPVQAKYIQHLTRRNSSQRPSAVQLL-QSELFQTS 586
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. UniProt/SwissProt
Match: sp|Q9Z2R9|E2AK1_MOUSE (Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Mus musculus OX=10090 GN=Eif2ak1 PE=1 SV=2) HSP 1 Score: 170.629 bits (431), Expect = 2.297e-44 Identity = 133/449 (29.62%), Postives = 209/449 (46.55%), Query Frame = 2 Query: 338 SFVQNFKP--IKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQV-------ENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSL--SHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHD---SLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRC----------LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLT--ANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILN 1606 S++Q + I F+ + ++ +N+F+ + +GKGG+GRVY NK+D Q YAIK+++I + + + ++E ++LA L H NIV YHT W E +V E + G K + SSS + + F S V + NN T +L +S S+I+ Q + + H + + TS +G L + + V + L+IQM+ C L+L DW+ RNK D E C + ++L++GV YIH+ ++HRD+KP NIFL D Q+KIGDFGL+ D + K T + GT Y++PE G YD KSD+YS+G+ILLEL F T+ E V+ + G + L + P++ ++++ L RP A +L Sbjct: 144 SYMQKIRSREIAFEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSA--TKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGHSSELEGNFTSTDESSEGNLNLLGQTEV---RYHLMLHIQMQLCELSLWDWITERNKRSREYVD----EAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL---HGPDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGS----QYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQ 576
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. UniProt/SwissProt
Match: sp|Q9BQI3|E2AK1_HUMAN (Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Homo sapiens OX=9606 GN=EIF2AK1 PE=1 SV=2) HSP 1 Score: 165.236 bits (417), Expect = 2.391e-42 Identity = 139/478 (29.08%), Postives = 218/478 (45.61%), Query Frame = 2 Query: 335 ISFVQNFK--PIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE-------RFEEAN--------WNSQVENFTNCS----GSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNV-----PKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRC----------LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI----------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKES 1630 IS +Q + + + + ++ +N+F+ + +GKGG+GRVY NK+D Q YAIK+++I + + ++E ++LA L H NIV YHT W E R + A + Q E+ C S ++SI I + S + + N +V TN +G L S ++ Q + ++ I E SH E + E NVN + L+IQM+ C L+L DW+ RNK D E C + ++L++GV YIH+ ++HRD+KP NIFL H D Q+KIGDFGL+ C +I + R T+ GT Y++PE G YD KSD+YS+G++LLEL F T+ E V+ + G + L + P++ +++++L RP A +L Q+ F+ S Sbjct: 143 ISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGA--TKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSI--IFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELE------STLELQENGLAGLSASSIVEQQLPLRR-----NSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVD----ESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--H-GPDQQVKIGDFGLA-------CTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGS----EYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLL-QSELFQNS 586
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. UniProt/SwissProt
Match: sp|Q63185|E2AK1_RAT (Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Rattus norvegicus OX=10116 GN=Eif2ak1 PE=1 SV=2) HSP 1 Score: 162.155 bits (409), Expect = 2.442e-41 Identity = 130/448 (29.02%), Postives = 209/448 (46.65%), Query Frame = 2 Query: 338 SFVQNFK--PIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQV-------ENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSL--SHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRC----------LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMK----LTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILN 1606 S++Q + I + + ++ +N+F+ + +GKGG+GRVY NK+D Q YAIK+++I + + + ++E ++LA L H NIV YHT W E +V E + G K + SSS + + S+V + NN +L S S+I+ Q S + ++ H D + +S D+ + + + L+IQM+ C L+L DW+ RN D E C + ++L++GV YIH+ ++HRD+KP NIFL H D Q+KIGDFGL+ K + ++ R K T+ GT Y++PE G YD KSD+YS+G+ILLEL F T+ E V+ + G + L + P++ ++++ L RP A +L Sbjct: 144 SYMQKIRSREIALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSA--TKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVLQPQDRVPIQLPSLEVLSEHEGDRNQGGVKDNESSSSIIFAELTPEKENPLAESDVKNENNNLVSYRANLVIRSSSESESSIELQEDGLNESPLRPVVKHQLPLGHSSDVEGNFTSTDESSEDNLNLLGQTEARYHLMLHIQMQLCELSLWDWIAERNNRSRECVD----EAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--H-GPDQQVKIGDFGLACADIIQKSADWTN-RNGKGTPTHTSRVGTCLYASPEQLEGS----EYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNAAQRPSALQLLQ 577
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. UniProt/SwissProt
Match: sp|Q9HGN1|GCN2_SCHPO (eIF-2-alpha kinase GCN2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gcn2 PE=2 SV=2) HSP 1 Score: 148.673 bits (374), Expect = 5.287e-36 Identity = 132/448 (29.46%), Postives = 215/448 (47.99%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCH-LNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-----------KFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDI-SKGIGFKDLIETWPL-----EDQHVRNLISNKPENRPEASFILNQTCC---FKESIVQNGL 1648 ++ V++ DF+ ++ +G+GGFG V N+ID + YA+K++++ ++KE + ++E L++L+H ++VRY+T W E EAN +++ +I S S + + S +M+ + SSL A SL D N D S+I F+YS+ + + SS+ ++E S + LYIQME+C L+LQD + R+K+ E+ L RQ+L+ + YIHS ++HRD+KP NIFL ++ +K+GDFGL+ K+ DE LT GTA Y APE+ + + + YD K D+YS+G+IL E+ + FST E +++ I S I F T+P E + + L+ + P RP + +L E +Q GL Sbjct: 545 YRKSVSRYETDFEELEFLGRGGFGEVVKVKNRIDGRFYAVKKLVLLS---DDKENSRILREVMTLSRLHHEHVVRYYTAWVE--TEAN----------------DTVTEIISSDSESLSQS----LNMAVDFRQSSSL---PADKLSSLDIHFEDDYNSSADEEDP--EASDISFQYSNTSDKEG------SSDKDSSIEEASSVKTQENGLNATLYIQMEYCEKLSLQDII--RDKI-------PVDEMWRLFRQILEALAYIHSRGMMHRDLKPGNIFL----DENRNVKLGDFGLATENENYQDNNDKWKNRQSADE-------DLTTGVGTALYVAPELLSRR-NGVRYDAKVDMYSLGIILFEMCMTFSTSMERIRIIDTIRSPSISFPS---TFPFSRASHEFKVIHCLLQHDPTKRPSSQELLESEAIPPKVGEEFIQEGL 932
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. TrEMBL
Match: A0A1L8EXZ4 (Protein kinase domain-containing protein OS=Xenopus laevis OX=8355 GN=eif2ak1 PE=1 SV=1) HSP 1 Score: 197.208 bits (500), Expect = 2.938e-51 Identity = 160/515 (31.07%), Postives = 246/515 (47.77%), Query Frame = 2 Query: 335 ISF-VQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVS---SLTNNSAFNTGSLS------------HSIYDRSNIDTQNSD---------CRHS--GSNIIFEYSSNFNHKHDSLTSHSS--EDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI-----------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFIL-NQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRL 1738 +SF V K + + + ++ +N+FD I +GKGG+G+VY NK+D Q YAIK+++I K++ ++ ++E ++LA L H NIV YHT W E + N SQ + GS N + + S+ +GS ++ S+ + TGS S HSI + +N ++S+ C S + FN + D S SS E+ ++C + + + L+IQM+ C +L DW+ RN +S DF +VR R Q+L+GV Y+HS V+HRD+KP N+FL D+ ++IGDFGL+ C +I + T GT Y+APE G YD KSD+YS+G+ILLEL F T+ E V+ + G WP++ + V+ L S++ RP AS +L +Q KE+IVQ D+ + L+ ENE L+K+L L+L Sbjct: 143 LSFHVSRAKKMLSETQTSRYLNEFDEIVQLGKGGYGKVYKVRNKLDGQFYAIKKILIK--KVSRRDCKKVLREVKVLAGLQHPNIVGYHTAWMEHVQPPN--SQCKLLKVIKGSSDNKAEQ-----------DMKGVQSVESSGSFITFEDSVEGDPGEQTGSESVNMSLSSLNKREHSIENAANNYRKDSNTNVTRKTRVCHKSYQSPGLCQRDECPFNSEEDVDKSDSSCDEECPQKDLCLHRHFEI-QYHLMLHIQMKLCEKSLWDWIVERNNHFQESGNSNPYDFVDVRITTRILYQILEGVRYVHSMGVLHRDLKPRNVFL---HGADLHVRIGDFGLA-------CRDIIQKSRDSWLNKDGSKGATHTTGVGTCLYAAPEQLKGS----RYDFKSDMYSIGIILLELFQPFGTEMERTRVLTALRNGTVPGSYERQWPVQSEFVKLLTSSECSERPSASQMLESQLFHQKENIVQ--------DLQKKVLDLEEENERLKKSLQKLQL 619
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. TrEMBL
Match: A0A099ZQU1 (Eukaryotic translation initiation factor 2-alpha kinase 1 (Fragment) OS=Tinamus guttatus OX=94827 GN=N309_06018 PE=4 SV=1) HSP 1 Score: 195.282 bits (495), Expect = 7.592e-51 Identity = 141/455 (30.99%), Postives = 222/455 (48.79%), Query Frame = 2 Query: 356 KPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYAN-----------SIPKIXXXXXXXXXXXXXXXTSM-SFNGSNVSSLTNNSAFNTGS-----------LSHSI--YDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGA----LEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKE---------VRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS----KFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEAS 1594 K F+ + ++ +N+FD I +GKGG+G+VY NK+D Q YAIK+ IN K ++ ++E ++LA L H NIV YHT W E + A + S N S I + + TS+ + N ++ S+ + F + S LS + Y +++D+ +SD ++ S Y +F+ +DS+ S +G+ + +C + V M LYIQM+ C ++L DW+ RNK S + F + ++C ++LL+GV YIHS V+HRD+KP NIFL D +KIGDFGL+ + + D + + I + T+ GT Y++PE G YD KSD+YS+G+ILLEL F T+ E V+ + G + WP++ ++V+ L S P RP A+ Sbjct: 112 KEFLFESQTSRYLNEFDEIARLGKGGYGKVYKVRNKLDGQFYAIKR--INIKKATRRDCMKVLREVKVLAGLQHPNIVGYHTAWMEHAQLACPKKAIMTLEPLSLEQENGNDHRHIQSVESDSSIIFADLTSQEKKSRDCTSLKNLNNESMPSMDEGNDFTSSSNKIYTKPDKCKLSVELQEYSTAHVDSTSSDFKNHSS-----YGPHFSLDNDSIAGSKSCIEGSSQTDIALCGAFEVEYRLM---LYIQMQLCEISLCDWIAERNKRCSERAEETFSQYHLVDVTWTMKCF-QELLEGVCYIHSMGVMHRDLKPRNIFLY---GSDRHVKIGDFGLACKDLLWHDADHWLKTNRINGLTHTSGVGTCLYASPEQLQGS----HYDFKSDMYSMGVILLELFQPFGTEMERTEVLMCLRNGHIPNTFYKKWPIQAKYVKLLTSKIPSQRPTAA 548
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. TrEMBL
Match: Q28EX6 (Eukaryotic translation initiation factor 2 alpha kinase 1 OS=Xenopus tropicalis OX=8364 GN=eif2ak1 PE=2 SV=1) HSP 1 Score: 195.282 bits (495), Expect = 1.670e-50 Identity = 150/481 (31.19%), Postives = 236/481 (49.06%), Query Frame = 2 Query: 377 KVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANS----IPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSI------YDR---SNIDTQNSDCRHS--GSNIIFEYSS-NFNHKHDSLTSHSS--EDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS--KFFEFDKCDEISSIRKMKLTANT--GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLR 1735 + ++ +N+FD I +GKGG+G+VY NK+D Q YAIK+++I K++ ++ ++E ++LA L H NIV YHT W E + NSQ + GS N + ++ S + S + +VS N S + H I Y + +N+ + C S ++ + F+ + D S SS E+ ++C + + + L+IQM+ C +L DW+ RN +S DF +VR R Q+L+GV YIHS V+HRD+KP N+FL D+ ++IGDFGL+ F+ + + R LT T GT Y+APE G YD KSD+YS+G+ILLEL F T+ E V+ + G WP++ V+ L S++ RP AS +L ES + + N ++D+ + L+ ENE L+++L L+ Sbjct: 158 QTSRYLNEFDEIAQLGKGGYGKVYKVRNKLDGQFYAIKKILIK--KVSRRDCRKVLREVKVLAGLQHPNIVGYHTAWMEHVQPP--NSQCKLLKAVKGSPNNKAEQDMKEVRSVESSGSFIMFEDSAHQDPSAQSVSESVNMSVSSPDKPDHCIENAGNNYKKDSNANVAKKTKACSKSYQSQGLVCQRDKCPFSSEDDVDKSDSSCDEECPQKDLCLHRHFEI-QYHLMLHIQMKLCEKSLWDWIVERNNHFQESGNSNPYDFVDVRITTRILYQILEGVRYIHSMEVLHRDLKPRNVFL---HGADLHVRIGDFGLACRDIFQQSRDSWLQKDRSNGLTHTTGVGTCLYAAPEQLKGS----HYDFKSDMYSIGIILLELFQPFGTEMERTQVLTALRNGTVPCSYERQWPVQSNFVKLLTSSECSERPSASQML-------ESQLFHQKENLVQDLQKKVLYLEEENERLKRSLQKLQ 619
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. TrEMBL
Match: A0A5N5MM44 (Uncharacterized protein OS=Pangasianodon hypophthalmus OX=310915 GN=PHYPO_G00034410 PE=4 SV=1) HSP 1 Score: 194.897 bits (494), Expect = 2.032e-50 Identity = 146/502 (29.08%), Postives = 240/502 (47.81%), Query Frame = 2 Query: 374 FKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHS-------SEDKGALEICKS-----------SNVNVPKMEFA------------LYIQMEFCHLNLQDWLCNRNKL--------VSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-KFFEFDKCDEISSIRKM------KLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQ 1744 F+ ++ +++FD I P+G+G +G+V+ +NK+D Q YA+K+++I + + ++E ++L+ L H NIV YHT W E + A NC + +IP + S ++ S NGS++ + NS + HS +N+ +NS S + E S K + H+ E + A E C + S V++ ++A LYIQM+ C +L+DW+ RN + Q D ++ + +++L+GVEYIHS ++HRD+KP NIFL H + +KIGDFGL+ K ++ +++SS + T GT Y++PE G YD KSD+YSVG+I +EL F T+ E + D+ KG DL + WP+ + ++ L S P RP AS +L + +V + L+ I S+ + E LR+ + +L+ SQ Sbjct: 165 FQTSRYLSEFDEISPLGRGSYGKVFKVINKLDGQHYAVKKILIK--NVTRNDCMKVIREVKVLSSLQHLNIVGYHTAWMEHVQPA--------VKNCKPTLLATIPALETPSQTERLVEE---STSSTNGSSI--VFENSECSKDRKGHS----TNV-LKNSSNNILRSTVATEQRSQVLSKKIVHSPHNFVPCAFLGEPRSAGETCPALRWESSTLSEESYVDMSSQQWAEKHPKEVQFHLMLYIQMQLCERSLKDWIQERNSTPKPELTMSTGSFQSFDSQQASDILKKILEGVEYIHSRGIMHRDLKPRNIFLNGH---ECHVKIGDFGLACKDIVMNENEQLSSTSHVNGNAESSHTTGVGTFVYASPEQLQGS----HYDSKSDMYSVGVIAVELFQPFGTEMERVQTLSDLRKGKVPDDLYKNWPVLTEQIKLLTSMDPSLRPSASQLLQSDLFNNKDMVIHNLHQRI-------SEQEEEIIQLRRQISELQTSQ 632
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. TrEMBL
Match: A0A5G3K809 (Protein kinase domain-containing protein OS=Xenopus tropicalis OX=8364 GN=eif2ak1 PE=4 SV=1) HSP 1 Score: 193.356 bits (490), Expect = 6.375e-50 Identity = 148/481 (30.77%), Postives = 235/481 (48.86%), Query Frame = 2 Query: 377 KVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQ----VENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSI------YDR---SNIDTQNSDCRHS--GSNIIFEYSS-NFNHKHDSLTSHSS--EDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS--KFFEFDKCDEISSIRKMKLTANT--GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLR 1735 + ++ +N+FD I +GKGG+G+VY NK+D Q YAIK+++I K++ ++ ++E ++LA L H NIV YHT W E + N + V+ F N + ++ S + S + +VS N S + H I Y + +N+ + C S ++ + F+ + D S SS E+ ++C + + + L+IQM+ C +L DW+ RN +S DF +VR R Q+L+GV YIHS V+HRD+KP N+FL D+ ++IGDFGL+ F+ + + R LT T GT Y+APE G YD KSD+YS+G+ILLEL F T+ E V+ + G WP++ V+ L S++ RP AS +L ES + + N ++D+ + L+ ENE L+++L L+ Sbjct: 158 QTSRYLNEFDEIAQLGKGGYGKVYKVRNKLDGQFYAIKKILIK--KVSRRDCRKVLREVKVLAGLQHPNIVGYHTAWMEHVQPPNSQCKLLKAVKGFPNNKAE--QDMKEVRSVESSGSFIMFEDSAHQDPSAQSVSESVNMSVSSPDKPDHCIENAGNNYKKDSNANVAKKTKACSKSYQSQGLVCQRDKCPFSSEDDVDKSDSSCDEECPQKDLCLHRHFEI-QYHLMLHIQMKLCEKSLWDWIVERNNHFQESGNSNPYDFVDVRITTRILYQILEGVRYIHSMEVLHRDLKPRNVFL---HGADLHVRIGDFGLACRDIFQQSRDSWLQKDRSNGLTHTTGVGTCLYAAPEQLKGS----HYDFKSDMYSIGIILLELFQPFGTEMERTQVLTALRNGTVPCSYERQWPVQSNFVKLLTSSECSERPSASQML-------ESQLFHQKENLVQDLQKKVLYLEEENERLKRSLQKLQ 619
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Cavefish
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:103026818]) HSP 1 Score: 187.193 bits (474), Expect = 4.475e-51 Identity = 145/496 (29.23%), Postives = 240/496 (48.39%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCS---GSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQN-SDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFA------------LYIQMEFCHLNLQDWLCNRN-----KLV---STLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-KFFEFDKCDEI---SSIRKMKLTANT---GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENEL--LRKTLDDLRLSQQKQH 1756 FQ + ++ +++F+ I +GKG +GRV+ NK+D Q YA+K+++I ++ + ++E ++L+ L H NIV YHT W E + A N N S GS + + ++ S++ ++ S + + S +T S +++ ++ + QN C G + S+ S +E+ +S +++ ++A LYIQM+ C +L+DW+ RN +L Q D +E + +++L+GVEYIHS ++HRD+KP NIFL H +KIGDFGL+ K +K +++ S I K +A+T GT Y++PE G YD KSD+YSVG+I +EL F T+ E H + ++ +G L E WPL + ++ L S P RP AS +L +V + I +K E E+ LRK + +L+ SQ +H Sbjct: 139 FQAQTSRYLSEFEEISTLGKGSYGRVFKVKNKLDGQHYAVKKILIK--NVSRDDCVKVLREVKVLSSLQHPNIVGYHTAWMEHVQPAVNNPTKPMLPNSSPALGSLSQTDGRLEESTNGSSIVFESSECSKDTKDPPTQTPQSTSVKSTPETSQAMFTKNMRNPQNFVPCVFLGKPRSVVDTCPALSWDTSVLSEDEASPNRVELNNNSYIDMDSQQWAEKHPKEVQFHLMLYIQMQLCERSLKDWIQERNCTPKAELAVAGGPYQPFDCEEAFNILKKILEGVEYIHSCGIMHRDLKPRNIFLHGHA---CHVKIGDFGLACKDIVANKQEQLHFNSHIGKNAESAHTTGVGTFVYASPEQLEGS----HYDSKSDMYSVGVIAVELFHPFGTEMERVHTLGELRRGKVPDTLAENWPLLTKQIKLLTSADPSLRPNASELLQSDLFNSRDMVIRSMQQQI---------VKQEEEIVQLRKQISELQSSQNSKH 616
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Cavefish
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:103026818]) HSP 1 Score: 186.808 bits (473), Expect = 8.192e-51 Identity = 145/496 (29.23%), Postives = 240/496 (48.39%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCS---GSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQN-SDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFA------------LYIQMEFCHLNLQDWLCNRN-----KLV---STLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLS-KFFEFDKCDEI---SSIRKMKLTANT---GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENEL--LRKTLDDLRLSQQKQH 1756 FQ + ++ +++F+ I +GKG +GRV+ NK+D Q YA+K+++I ++ + ++E ++L+ L H NIV YHT W E + A N N S GS + + ++ S++ ++ S + + S +T S +++ ++ + QN C G + S+ S +E+ +S +++ ++A LYIQM+ C +L+DW+ RN +L Q D +E + +++L+GVEYIHS ++HRD+KP NIFL H +KIGDFGL+ K +K +++ S I K +A+T GT Y++PE G YD KSD+YSVG+I +EL F T+ E H + ++ +G L E WPL + ++ L S P RP AS +L +V + I +K E E+ LRK + +L+ SQ +H Sbjct: 177 FQAQTSRYLSEFEEISTLGKGSYGRVFKVKNKLDGQHYAVKKILIK--NVSRDDCVKVLREVKVLSSLQHPNIVGYHTAWMEHVQPAVNNPTKPMLPNSSPALGSLSQTDGRLEESTNGSSIVFESSECSKDTKDPPTQTPQSTSVKSTPETSQAMFTKNMRNPQNFVPCVFLGKPRSVVDTCPALSWDTSVLSEDEASPNRVELNNNSYIDMDSQQWAEKHPKEVQFHLMLYIQMQLCERSLKDWIQERNCTPKAELAVAGGPYQPFDCEEAFNILKKILEGVEYIHSCGIMHRDLKPRNIFLHGHA---CHVKIGDFGLACKDIVANKQEQLHFNSHIGKNAESAHTTGVGTFVYASPEQLEGS----HYDSKSDMYSVGVIAVELFHPFGTEMERVHTLGELRRGKVPDTLAENWPLLTKQIKLLTSADPSLRPNASELLQSDLFNSRDMVIRSMQQQI---------VKQEEEIVQLRKQISELQSSQNSKH 654
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Cavefish
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:103026818]) HSP 1 Score: 176.792 bits (447), Expect = 1.182e-47 Identity = 144/505 (28.51%), Postives = 231/505 (45.74%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTV------------WFERFEEA-NWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIY---DRSNIDTQNSDCRHSGSNIIFEYSSNF----NHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRN-----KLV---STLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKL------------TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENEL--LRKTLDDLRLSQQKQH 1756 FQ + ++ +++F+ I +GKG +GRV+ NK+D Q YA+K+++I ++ + ++E ++L+ L H NIV YHT W R EE+ N +S V + CS + + STS+ ++ + N + ++ RS +DT + + E S N N+ + + S +K E+ + LYIQM+ C +L+DW+ RN +L Q D +E + +++L+GVEYIHS ++HRD+KP NIFL H +KIGDFGL+ C +I + ++ +L T GT Y++PE G YD KSD+YSVG+I +EL F T+ E H + ++ +G L E WPL + ++ L S P RP AS +L +V + I +K E E+ LRK + +L+ SQ +H Sbjct: 110 FQAQTSRYLSEFEEISTLGKGSYGRVFKVKNKLDGQHYAVKKILIK--NVSRDDCVKVLREVKVLSSLQHPNIVGYHTAWMEHVQPAVNSKWLGRLEESTNGSSIVFESSECSKDTKDP------------PTQTPQSTSVKSTPETSQAMFTKNMRNPQNFVPCVFLGKPRSVVDTCPALSWDTSVLSEDEASPNRVELNNNSYIDMDSQQWAEKHPKEV---------QFHLMLYIQMQLCERSLKDWIQERNCTPKAELAVAGGPYQPFDCEEAFNILKKILEGVEYIHSCGIMHRDLKPRNIFLHGHA---CHVKIGDFGLA-------CKDIVANKQEQLHFNSHIGKNSAHTTGVGTFVYASPEQLEGS----HYDSKSDMYSVGVIAVELFHPFGTEMERVHTLGELRRGKVPDTLAENWPLLTKQIKLLTSADPSLRPNASELLQSDLFNSRDMVIRSMQQQI---------VKQEEEIVQLRKQISELQSSQNSKH 568
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Cavefish
Match: eif2ak3 (eukaryotic translation initiation factor 2-alpha kinase 3 [Source:ZFIN;Acc:ZDB-GENE-050414-2]) HSP 1 Score: 112.079 bits (279), Expect = 2.595e-25 Identity = 81/238 (34.03%), Postives = 126/238 (52.94%), Query Frame = 2 Query: 962 LEICKSSNVNVPKM--EFALYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRCLA--RQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGL--SKFFEFDKCDEISSIRKMKL----TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGF-----KDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKE 1627 L C S+ P + + LYIQM+ C NL+DW+ R+ Q + +CLA Q+ + V++IHS ++HRD+KP+NIF + D +K+GDFGL + E D +++S++ M + T GT Y +PE +G SY HK D+YS+G+IL EL+ F TQ E + ++ + + F K+ ++ E VR ++S P RPEAS I + F+E Sbjct: 689 LPPCPSTPSARPPLTPKVYLYIQMQLCRKENLKDWMAQRS------QPEHREHSQCLAIFLQIAEAVDFIHSKGLMHRDLKPSNIFFTL----DDVVKVGDFGLVTAMDQEEDDDEDLSTLTPMPMYARHTGQVGTKLYMSPEQMSGN----SYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEV-RALQFPTAFYKNNVQ----EVSMVRCMLSRVPAERPEASEI-TEAPLFQE 906 HSP 2 Score: 64.3142 bits (155), Expect = 2.443e-10 Identity = 34/105 (32.38%), Postives = 61/105 (58.10%), Query Frame = 2 Query: 344 VQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIA--DTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVEN 652 V + +P ++ V++ + DF+ ++ +G+GGFG V+ A NK+D YAIK++ +L +E+A ++E + LAKL H I+RY W E + W +++ Sbjct: 435 VSDARPSEY---VSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRI-----RLPNREVAREKVMREVKALAKLEHPGIIRYFNAWQESPPQG-WQEEMDQ 530
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Cavefish
Match: eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2 [Source:ZFIN;Acc:ZDB-GENE-080422-1]) HSP 1 Score: 103.99 bits (258), Expect = 6.332e-23 Identity = 70/201 (34.83%), Postives = 102/201 (50.75%), Query Frame = 2 Query: 1013 LYIQMEFCHLN-LQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQT 1612 LYIQME C + LQ W+ N + + +E + Q+LK VEYIHS N+IHRD+KPANI +K+ LK+GDFGL E D + + ++ T TGT SYD K D++ +G+I EL+ T E V +D+ +D + + LE + + ++S PE RP+AS +L T Sbjct: 403 LYIQMELCEGDTLQFWIETENTKDPSPERR--QEAAKIMTQVLKAVEYIHSVNLIHRDLKPANIMF----TKEKVLKVGDFGLVTAAETDSDEAL-----LERTNRTGT----------------SYDKKVDIFPLGLIYFELLWNLKTGHEKAEVWKDVRSRKLPEDFSKKFMLESKLIEQMLSASPEERPDASDLLANT 576 HSP 2 Score: 63.1586 bits (152), Expect = 5.058e-10 Identity = 33/75 (44.00%), Postives = 44/75 (58.67%), Query Frame = 2 Query: 389 LINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE 613 + +F+SI +GKGGFGRV+ A I+ + YA+K V K + ++E LAKL H NIVRYHT W E Sbjct: 315 FLENFNSISKLGKGGFGRVFKARKVIEQKDYAVKIV---------KYTSKALREVAALAKLVHPNIVRYHTSWIE 380
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Sea Lamprey
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268]) HSP 1 Score: 184.882 bits (468), Expect = 1.685e-51 Identity = 126/437 (28.83%), Postives = 206/437 (47.14%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNG-SNVSSLTNNSAFNTGSLSHSIYDRSNIDTQN-------SDCRHSGSNIIFEYS-SNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS----DFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI-----------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILN 1606 F ++ +++F+ + +G+GG+G+V+ NK+D Q+YA+K+V+I S E ++E ++LA L H +IV YH W E + + + + ++ + + + N S +S N ++ N S S + SN N S+ +H GSN +E+S SN H +S TS + S+ + LYIQM+ C +L++WL +RN L+ D K+ + +QLL+GV YIHS ++HRD+KP NIFL D ++IGDFGL+ C +I + + T+ GT Y+APE +G YD KSD+YSVG++L EL F T+ E ++++ G+ WP++ +++ L + P RP IL Sbjct: 94 FHMHTSRYLSEFEEVCRLGRGGYGQVFKVRNKLDRQLYAVKKVLIKGS--GESICKKVLREVKLLAGLQHLSIVGYHGAWLELLQPPTLAAPFQPLPSAEAGCQRNVGWCPPGRFSSCHVPSLVQAHGGLNSESRDNSGHNKNSINEDSGRKSEHSGSNGKPTNLRKELYESNSKHVGSN--YEHSESNSEHSENSNTSWTP----------GSDSKDRDLHLVLYIQMQLCERSLKEWLMDRNALLQQCTGRYALVDGKQTTRMFQQLLEGVHYIHSRGIMHRDLKPRNIFL---HGPDHHVRIGDFGLA-------CQDIVYEDPRLIRAGAGVVGSAHTSGVGTTLYAAPEQLSGS----HYDFKSDMYSVGIVLFELFQPFGTEMERVKTIQELRGGVVSSPFTAQWPVQAKYIGLLTQDDPAARPNPQDILT 502
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007738.1 (pep scaffold:Pmarinus_7.0:GL476507:25231:69652:1 gene:ENSPMAG00000006975.1 transcript:ENSPMAT00000007738.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 136.732 bits (343), Expect = 1.107e-33 Identity = 134/460 (29.13%), Postives = 217/460 (47.17%), Query Frame = 2 Query: 371 QFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFE----EANWNSQVEN---------FTNCSG------SYANSIPKIXXXXXXXXXXXXXXXTSMSFN-------GSNVSSLTNNSAFNTGSLSHSIYDRSNIDT-QNSDCRHSGSNIIFEYSSNFNHK---HDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLN-LQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSK-----FFEFDKCDEISSIRKMK---------LTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMV-KFSTQSELCHVVEDIS-KGIGFKDLIETWPLEDQH--VRNLISNKPENRPEASFIL 1603 Q ++++ +F+ + +GKG FG V NK+D YA+K++ +N + + I E +L++LNH NIVRY+ W ER+E +A V N + SG AN+ P ++ S+ + SV SMS+ G + + + + + + ++ RS + + +SDC +++FE S N HDS S K +C+ + P + L+IQME+C + L+D + +K + D ++ L R++L G+ YIH +IHRD+KP NIFL S D +KIGDFGL+ E K D ++ ++ LT GTA Y +PEV G K + Y+ K DLYS+G+I E+ +T SE V++ + I F + L+ Q +R L+++ RP A +L Sbjct: 606 QRQLSRYYTEFEELALLGKGAFGAVIKVKNKLDGCYYALKRIAVNPTSRQFRRIKG---EVTLLSRLNHENIVRYYNAWIERYELSPSDAKETPDVANVRGRGPAMHLSRLSGIAGLDDVEANAPPPVTASTRTVASGSVEW--SMSYEHSVSARCGPSTTGGSPSDSSDEDDEDDVVFGRSFVPSGSDSDC-----DVVFENSGEKNQSEESHDSSLSDKELSKNRAPVCQPT----PTVVHHLFIQMEYCERSTLRDTI---DKGLHMETDRMWR----LFREILDGLAYIHEQGMIHRDLKPVNIFL---DSSD-SVKIGDFGLATDHRLVATESSKIDVSTANIELPTENMDVTGGLTGQIGTALYVSPEVL-GNIKAV-YNQKVDLYSLGIIFFEMTYHPMTTASERVAVLQKLRLPTIQFPEDFHPQTLKQQAFIIRWLLNHDAGQRPTAQELL 1038
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006924.1 (pep scaffold:Pmarinus_7.0:GL476537:325917:352372:-1 gene:ENSPMAG00000006216.1 transcript:ENSPMAT00000006924.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 105.531 bits (262), Expect = 7.095e-24 Identity = 71/222 (31.98%), Postives = 108/222 (48.65%), Query Frame = 2 Query: 977 SSNVNVPKMEFALYIQMEFCHLN-LQDWLCNRNKLVSTLQDSDFKEVRCLA--RQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKL--TANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKE 1627 +S P LYIQM+ C + L++WL +R +D CL +Q++ V+++H + ++HRD+KP+NIF S D +KIGDFGL E ++ + + + T GT Y +PE G+ +Y HK D++S+G+IL EL+ F TQ E + I + + E Q V L++ P RPEA I Q F E Sbjct: 762 ASTETGPVPRLFLYIQMQLCRKDSLKEWLNSRTNA------ADRSRAECLTIFQQIVNAVQFLHVSGLMHRDLKPSNIFF----SLDGVVKIGDFGLVTGTEHEEEGAVLTPMPGHIHHTGQVGTKLYMSPEQLAGR----AYSHKVDIFSLGLILFELLCPFGTQMERIKTLSAARNRIFPDPFVTSNVDEHQLVERLLAQDPSLRPEAEEI-AQAALFAE 968 HSP 2 Score: 63.929 bits (154), Expect = 7.391e-11 Identity = 34/102 (33.33%), Postives = 58/102 (56.86%), Query Frame = 2 Query: 380 VNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQV-IINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVEN--FTNCSGSY 676 V++ + DF+ ++ +G+GGFG V+ A NK+D YAIK++ + N + EK ++E + LAKL H +VRY W E +W + + ++CS + Sbjct: 477 VSRYLTDFEHVQCLGRGGFGVVFEARNKVDDCHYAIKRIRLPNRIQAREK----VMREVKALAKLEHQGVVRYFNAWLE-MPPQDWQEEKDKQWISDCSSEW 573
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000555.1 (pep scaffold:Pmarinus_7.0:GL477093:35206:42652:1 gene:ENSPMAG00000000500.1 transcript:ENSPMAT00000000555.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 81.2629 bits (199), Expect = 3.080e-18 Identity = 54/166 (32.53%), Postives = 89/166 (53.61%), Query Frame = 2 Query: 1130 QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLI-ETWPLEDQHVRN-------LISNKPENRPEASFIL 1603 Q+ V+YIHS ++HRDIK +N+FL +K +K+GDFG+SK E M +T GT +Y +PE+ C+ + Y KSD++++G +L EL E +++ + + +K + E PL++ + R+ L+S PE+RP AS +L Sbjct: 16 QVCMAVQYIHSVKILHRDIKTSNVFL----TKAGTVKVGDFGISKAME--------GTLDMAVTC-VGTPYYLSPEM----CQDLPYSSKSDVWALGCLLYEL-CALRPAFEASNIIRLTRRSLFYKIMRGEPDPLDESYSRDVRALVALLLSRSPEDRPSASAVL 163
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Sea Lamprey
Match: stk35 (serine/threonine kinase 35 [Source:ZFIN;Acc:ZDB-GENE-061103-553]) HSP 1 Score: 76.2554 bits (186), Expect = 7.201e-16 Identity = 44/156 (28.21%), Postives = 83/156 (53.21%), Query Frame = 2 Query: 995 PKMEFALYIQMEFC-HLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFF--EFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFS 1453 P + L++ ME+C ++ +L +R D A QL + V ++H N+++HRD+KP NI + + + + LK+ DFGLSK F + S+ + L+ G++FY APEV+ G + K+D++++G+I+ ++ + + Sbjct: 7 PGNSYYLWLVMEYCDGGDMNGYLLSRQP--------DHWLNTSFAMQLSRAVAFLHRNSIVHRDLKPDNILVAENSGRPV-LKVADFGLSKIFAGQGQGLSSGESVNRAWLSPACGSSFYMAPEVWEGH-----FTAKADIFALGIIVWAMLERIT 148
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Yeast
Match: GCN2 (Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691]) HSP 1 Score: 134.806 bits (338), Expect = 2.375e-33 Identity = 128/420 (30.48%), Postives = 207/420 (49.29%), Query Frame = 2 Query: 395 NDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGS-LSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVP----KMEFALYIQMEFCH-LNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSK-------FFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDI-SKGIGFKDLIE--TWPLEDQHVRNLISNKPENRPEASFILN 1606 +DF+ I +G+G FG+V A N +D + YAIK++ + E++++ + E +LA LNH +VRY+ W E +S EN + ++ S SSS + ++ +S+ N +N +N F +GS +++ S+ D +N D H S+ S + K E K + + N P K + L+IQME+C L D + + N ++ +D ++ L RQ+L+ + YIHS +IHRD+KP NIF I S+++ KIGDFGL+K + D + S LT+ GTA Y A EV +G Y+ K D+YS+G+I E++ FST E ++++ + S I F + +E + +R LI + P RP A +LN Sbjct: 597 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKI-----RHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLEE------DSMDENVFESTDEESDL----SESSSDFEENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDK---------ESKSIQNVPRRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSEN--LNQQRDEYWR----LFRQILEALSYIHSQGIIHRDLKPMNIF--IDESRNV--KIGDFGLAKNVHRSLDILKLDSQNLPGS--SDNLTSAIGTAMYVATEVLDGTGH---YNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN 977
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Yeast
Match: DUN1 (Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role [Source:SGD;Acc:S000002259]) HSP 1 Score: 78.5666 bits (192), Expect = 7.331e-16 Identity = 55/136 (40.44%), Postives = 71/136 (52.21%), Query Frame = 2 Query: 1109 EVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLII----HPSK-----------DIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANT--GTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSE 1465 E + L +QLL G++Y+H N+IHRDIKP NI L I +PS+ DIQ+KI DFGL+KF +M+ T NT GT Y APEV K Y K DL+S G+IL + F S+ Sbjct: 304 ESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKF-----------TGEMQFT-NTLCGTPSYVAPEVLTKK----GYTSKVDLWSAGVILYVCLCGFPPFSD 423
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 74.3294 bits (181), Expect = 3.217e-14 Identity = 61/187 (32.62%), Postives = 91/187 (48.66%), Query Frame = 2 Query: 1112 VRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQS--ELCHVVEDISKGIGFKDLIE-TWPLEDQHVRNLISN----KPENRPEASFIL-------NQTCCFKES 1630 ++ L Q+LKG+ Y+HS ++HRD+K N+ L +D KI DFG+S+ K +I S M + GT F+ APE+ + K Y K D++S+G I+LE+ S E+ + I K + E T PL Q RN + PE RP A+ +L N+T FK + Sbjct: 1280 IKHLTTQVLKGLAYLHSKGILHRDMKADNLLL----DQDGICKISDFGISR-----KSKDIYSNSDMTM---RGTVFWMAPEMVDTKQ---GYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKST 1451
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757]) HSP 1 Score: 70.0922 bits (170), Expect = 4.051e-13 Identity = 53/153 (34.64%), Postives = 84/153 (54.90%), Query Frame = 2 Query: 1010 ALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELM-VKFSTQSE 1465 ++YI ME+ D + +N L + S+ K + +A +L+G+ Y+H VIHRDIKP NI L +++ Q+K+ DFG+S + ++S+ T TGT+FY APE G+ Y SD++S+G+ +LE+ KF SE Sbjct: 294 SIYIAMEYMGGRSLDAIY-KNLLERGGRISE-KVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILL----NENGQVKLCDFGVS-------GEAVNSL----ATTFTGTSFYMAPERIQGQ----PYSVTSDVWSLGLTILEVANGKFPCSSE 425
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 70.0922 bits (170), Expect = 4.732e-13 Identity = 73/260 (28.08%), Postives = 120/260 (46.15%), Query Frame = 2 Query: 1013 LYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMV-KFSTQSELCHVVEDISKGIGFKDLIETWPLEDQH---VRNLISNKPENRPEASFILNQT---CCFKESIVQNGLYN--HIKDIMSENSKLK----SENELLRKTLDDLRLSQQKQ 1753 +YI +E C L R K+++ EVR Q+ ++Y+HS VIHRD+K NIF + LKIGDFGL+ + S RK + GT Y APEV GK S++ D++S+G++L L++ K Q+ + + + K F P+ D+ +R+++S P RP + I++ F SI + + +DI E S + E LL +++ ++ +QK+ Sbjct: 154 VYILLEICPNGSLMELLKRRKVLTE------PEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFF----DSNYNLKIGDFGLAAVLANE------SERKYTI---CGTPNYIAPEVLMGKHSGHSFE--VDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDF-SFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKR 391
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Nematostella
Match: EDO46416 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ17]) HSP 1 Score: 107.842 bits (268), Expect = 1.652e-24 Identity = 91/300 (30.33%), Postives = 143/300 (47.67%), Query Frame = 2 Query: 923 DSLTSHSSEDKGALEICKSSNVNVPK---MEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLA--RQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKD------IQLKIGDFGLSK---FFEFDKCDEISSI---------------RKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSE----NELLRKTL 1723 +SL S S DK +S + V + + L+IQM+ C L DWL +RN + + V +A RQ+++GV YIHS ++HRD+KP NIFL +D +Q+KIGDFGL++ D ++S+ K T GT Y+APE + + Y +K+D+YS+G+IL EL F T+ E ++++ +G K WP E V +S + E + + + K I++ L ++ SEN KL+ E NEL+R+ + Sbjct: 377 NSLVSLSGNDK-----SESPSTQVARKKTLGMMLFIQMQLCTTTLCDWLQSRN-----FKGGNVDTVASMAIFRQIVEGVRYIHSQGLMHRDLKPRNIFLQSLTRRDEQTTAPLQVKIGDFGLARKDAVLYPDTSSPLASLIEPLSHHNPFLPGLSTKDAPTCGVGTCTYAAPE----QLRNTDYANKADMYSLGIILFELYWPFGTEMERVTSIKNLRQGNLPKAFSHRWPAE---VSQQLSEQLEMQSK------EIDELKNVIIEKDL--ELEAQGSENEKLQQELAERNELIRRLM 651 HSP 2 Score: 61.6178 bits (148), Expect = 5.599e-10 Identity = 27/73 (36.99%), Postives = 46/73 (63.01%), Query Frame = 2 Query: 395 NDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE 613 ++F + +GKGGFG V NK+D + YA+K+V++ + + ++E ++LA+LNH N+V YH+ W E Sbjct: 175 DEFVEMGRLGKGGFGSVLKVKNKLDGREYAVKKVLLK--ETDPGLCLKILREVKVLARLNHVNVVGYHSAWLE 245
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Nematostella
Match: EDO48785 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIC0]) HSP 1 Score: 106.686 bits (265), Expect = 5.292e-24 Identity = 81/251 (32.27%), Postives = 122/251 (48.61%), Query Frame = 2 Query: 971 CKSSNVNVPKMEFALYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFKEVRC--LARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMK-----LTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSE 1699 C S ++ P LYIQM+ C +L+DWL N ST +D + C + Q++ VEY H+ ++HRD+KP+NIF S D +K+GDFGL + D EI T GT Y +PE GK +Y K D++S+G+IL EL FST+ E V+ ++ K I + + L+ Q V + S+ P RP A+ I + +Y +I + + +K+KSE Sbjct: 768 CTSDILSAP---LYLYIQMQLCQRESLKDWLKNN----STRED-----IFCFNVFEQIVNAVEYFHNRGMMHRDLKPSNIFF----SLDGLVKVGDFGLVTATKQDNIHEIQETDNPGDLDGNHTGQVGTQLYMSPEQIEGK----AYSFKVDIFSLGLILFELFHPFSTEMERIKVMSNVKKRIMPAEFKTSMTLQSQLVTWMTSDLPTERPTAA-----------EIQSSDIYKNIITLSKQGTKVKSE 987 HSP 2 Score: 65.0846 bits (157), Expect = 6.769e-11 Identity = 39/100 (39.00%), Postives = 55/100 (55.00%), Query Frame = 2 Query: 383 NQLINDFDSIKPIGKGGFGRVYSAVNKI-DCQIYAIKQV-IINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSY 676 ++ + DF+ +GKGGFG V+ A NK+ DCQ YAIK+V + NC + K ++E + LAKL H IVRY WFE W +++ G Y Sbjct: 484 SRYLTDFEHELCLGKGGFGLVFQARNKVDDCQ-YAIKRVRLPNCDEARAK----VMREVKALAKLEHSGIVRYFNAWFEA-PPVGWQEELDEKMVDDGKY 577
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Nematostella
Match: EDO35699 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKU3]) HSP 1 Score: 87.8113 bits (216), Expect = 3.387e-18 Identity = 67/205 (32.68%), Postives = 107/205 (52.20%), Query Frame = 2 Query: 1010 ALYIQMEFCHLN-LQDWLCNRNKLVSTLQDSDFKE--VRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDK-CDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMV--KFSTQSELCHVVEDISKGIGFKDLIETWPLE-DQHVRNLISNKPENRPEASFIL 1603 +L+I+ME+C+ L D +C +N+L F E V Q+ V +IH N ++HRDIK NIFL +K +K+GDFG+SK + + D I GT +Y +PE+ GK Y+ KSD+++VG +L E++ + S +V DI KG ++++ E + E + V L+S P++RP +L Sbjct: 88 SLFIEMEYCNGGTLHDKICVQNEL--------FPEEVVIWYFFQICAAVGHIHENGIVHRDIKTMNIFL----TKSGLVKLGDFGISKILDSEGMADSI-----------VGTPYYMSPEIVQGK----KYNQKSDMWAVGCVLYEVLTLKRVFDASNPLRLVSDIVKG-HYEEIDERYTEEMNSLVNKLLSQNPDDRPSVQELL 264
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Nematostella
Match: EDO49138 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH03]) HSP 1 Score: 78.9518 bits (193), Expect = 1.984e-16 Identity = 51/157 (32.48%), Postives = 85/157 (54.14%), Query Frame = 2 Query: 1130 QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFS--TQSELCHVVEDISKGIGFKDLIETW-PLEDQHVRNLISNKPENRPEA 1591 QLL +++IH N++HRD+K NIFL +KD +KIGDFG+++ + CD + GT +Y +PE+ C+R Y++KSD++++G +L EL + T L ++V I G + + + PL + V ++ P +RP A Sbjct: 110 QLLLALKHIHGQNILHRDLKTQNIFL----TKDDVVKIGDFGIARILD-STCDHART--------TVGTPYYLSPEI----CQRQPYNNKSDIWALGCVLYELTTRTHPFTADNLTNLVVKILHG-NYPPIPRFYGPLLEDLVAVMLKINPADRPSA 248
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Nematostella
Match: EDO37567 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFE6]) HSP 1 Score: 73.1738 bits (178), Expect = 4.271e-14 Identity = 41/110 (37.27%), Postives = 64/110 (58.18%), Query Frame = 2 Query: 1109 EVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLEL 1438 +++ L Q+L GV+++H++ ++HRDIKP NI + +KD Q+KI DFGL++ ++ M LT+ T +Y APEV + SY D++SV IL EL Sbjct: 114 KIKDLTYQILNGVDFLHTHRIVHRDIKPQNILV----TKDGQVKIADFGLARVYK----------DAMALTSVVVTLWYRAPEVL----LQSSYATSVDIWSVACILAEL 205
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Medaka
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:NCBI gene;Acc:101172779]) HSP 1 Score: 131.724 bits (330), Expect = 1.796e-31 Identity = 135/481 (28.07%), Postives = 224/481 (46.57%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXX-----------------XXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFA--LYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSK---------FFEFDKCDEISSIRK---MKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVK-FSTQSELCHV-----VEDISKGIGFKDLIETWPLEDQHVRN-----LISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMS 1675 Q + ++ N+F+ ++ +GKG FG V NK+D YA+K++ +N + K+ E +L++LNH NIVRY+ W ER E + + ++ + S A+ PK S +SSV STS+ + S S +S + ++ S + + +SD R S+IIF+ N + D ++ ++ A + +S + + ++ A LYIQME+C ++ L T+ S D + L R++L G+ YIH +IHRD+KP NIFL S+D +KIGDFGL+ FE + + ++ +T GTA Y +PEV G K +Y+ K DL+S+G+IL E+ + +T +E V VE IS L E +P +Q + L+ + P RP A +L + ++ L+ ++ M+ Sbjct: 459 LQRQFSRYFNEFEELQLLGKGAFGAVIKVQNKLDGCYYAVKRIQVNPAS---KQFRRIKGEVTLLSRLNHENIVRYYNAWIERHELPSTGIPSNSDSSEAQSPADQHPKSRASPQRMNELGLPDNVEDMAPPPALSSSVEWSTSIEKSSSAKCSGHQSSDEDEDEDDEDVFGASFLPS-DSDSR---SDIIFD---NGDESADEMSQAEKSERPATDTTESLDSDR-QLSIAHYLYIQMEYC---------EKSTLRDTIDQSLHLDQNRLWRLFREILDGLAYIHEQGMIHRDLKPVNIFL---DSQD-HVKIGDFGLATDHPANVAAGKFELEDSGSAAVLKPDPTGNMTGMVGTALYVSPEV-QGNTK-ATYNQKVDLFSLGIILFEMSYRPMTTGAERISVLGKLRVEPIS-------LPEDFPAYNQGTQRKVIEWLLKHDPALRPTAQELLKSELLPPPQMEESELHEVLQHTMA 906
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Medaka
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:NCBI gene;Acc:101172779]) HSP 1 Score: 131.724 bits (330), Expect = 2.079e-31 Identity = 135/481 (28.07%), Postives = 224/481 (46.57%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXX-----------------XXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFA--LYIQMEFCHLNLQDWLCNRNKLVSTLQDS---DFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSK---------FFEFDKCDEISSIRK---MKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVK-FSTQSELCHV-----VEDISKGIGFKDLIETWPLEDQHVRN-----LISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMS 1675 Q + ++ N+F+ ++ +GKG FG V NK+D YA+K++ +N + K+ E +L++LNH NIVRY+ W ER E + + ++ + S A+ PK S +SSV STS+ + S S +S + ++ S + + +SD R S+IIF+ N + D ++ ++ A + +S + + ++ A LYIQME+C ++ L T+ S D + L R++L G+ YIH +IHRD+KP NIFL S+D +KIGDFGL+ FE + + ++ +T GTA Y +PEV G K +Y+ K DL+S+G+IL E+ + +T +E V VE IS L E +P +Q + L+ + P RP A +L + ++ L+ ++ M+ Sbjct: 573 LQRQFSRYFNEFEELQLLGKGAFGAVIKVQNKLDGCYYAVKRIQVNPAS---KQFRRIKGEVTLLSRLNHENIVRYYNAWIERHELPSTGIPSNSDSSEAQSPADQHPKSRASPQRMNELGLPDNVEDMAPPPALSSSVEWSTSIEKSSSAKCSGHQSSDEDEDEDDEDVFGASFLPS-DSDSR---SDIIFD---NGDESADEMSQAEKSERPATDTTESLDSDR-QLSIAHYLYIQMEYC---------EKSTLRDTIDQSLHLDQNRLWRLFREILDGLAYIHEQGMIHRDLKPVNIFL---DSQD-HVKIGDFGLATDHPANVAAGKFELEDSGSAAVLKPDPTGNMTGMVGTALYVSPEV-QGNTK-ATYNQKVDLFSLGIILFEMSYRPMTTGAERISVLGKLRVEPIS-------LPEDFPAYNQGTQRKVIEWLLKHDPALRPTAQELLKSELLPPPQMEESELHEVLQHTMA 1020
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Medaka
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:NCBI gene;Acc:101174538]) HSP 1 Score: 128.642 bits (322), Expect = 7.416e-31 Identity = 80/245 (32.65%), Postives = 122/245 (49.80%), Query Frame = 2 Query: 1007 FALYIQMEFCHLNLQDWLCNRNKLVSTLQDS-------DFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI---------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLK 1693 LYIQM+ C +L+DW+ RN S D + L R +L+GVEYIH+ ++HRD+KP NIFL D ++IGDFGL+ C +I SS T+ GT Y++PE G YD KSD+YS+G+I LEL F T+ E + D+ +G + WP+ ++++NL S +P R A+ +L + +V +GL +++ E +L+ Sbjct: 367 LMLYIQMQLCDRSLKDWISERNSWSKEEDISRGHYDCVDAEHTLSLLRHVLEGVEYIHAKGIMHRDLKPRNIFL---QGPDCHVRIGDFGLA-------CRDILVDGYKRSNSSGSDSIHTSGVGTFVYASPEQLKGS----HYDSKSDMYSIGVIALELFQPFGTEMERVRTLGDLREGKVPDSFHQRWPVLSKYIKNLTSKEPSVRLTATQLLQSELFSSKDMVIHGLQRRVEEQREEIMQLR 597 HSP 2 Score: 70.4774 bits (171), Expect = 2.525e-12 Identity = 29/87 (33.33%), Postives = 57/87 (65.52%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA 628 F + ++ +++F+ I +GKG +G V+ NK+D Q YA+K+++I K+++++ ++E ++L+ L+H N+V YHT W E + A Sbjct: 141 FLGQTSRYLSEFEEICRLGKGSYGNVFKVRNKLDAQFYAVKKILIK--KVSKEDCMKVLREVKVLSSLHHVNVVGYHTAWMEHVQPA 225
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Medaka
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:NCBI gene;Acc:101174538]) HSP 1 Score: 123.635 bits (309), Expect = 3.343e-29 Identity = 75/219 (34.25%), Postives = 110/219 (50.23%), Query Frame = 2 Query: 998 KMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDS-------DFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEI---------SSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILN 1606 + LYIQM+ C +L+DW+ RN S D + L R +L+GVEYIH+ ++HRD+KP NIFL D ++IGDFGL+ C +I SS T+ GT Y++PE G YD KSD+YS+G+I LEL F T+ E + D+ +G + WP+ ++++NL S +P R A+ +L Sbjct: 399 QFHLMLYIQMQLCDRSLKDWISERNSWSKEEDISRGHYDCVDAEHTLSLLRHVLEGVEYIHAKGIMHRDLKPRNIFL---QGPDCHVRIGDFGLA-------CRDILVDGYKRSNSSGSDSIHTSGVGTFVYASPEQLKGS----HYDSKSDMYSIGVIALELFQPFGTEMERVRTLGDLREGKVPDSFHQRWPVLSKYIKNLTSKEPSVRLTATQLLQ 603 HSP 2 Score: 70.8626 bits (172), Expect = 2.342e-12 Identity = 29/87 (33.33%), Postives = 57/87 (65.52%), Query Frame = 2 Query: 368 FQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEA 628 F + ++ +++F+ I +GKG +G V+ NK+D Q YA+K+++I K+++++ ++E ++L+ L+H N+V YHT W E + A Sbjct: 176 FLGQTSRYLSEFEEICRLGKGSYGNVFKVRNKLDAQFYAVKKILIK--KVSKEDCMKVLREVKVLSSLHHVNVVGYHTAWMEHVQPA 260
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Medaka
Match: ENSORLT00000043016.1 (interferon-induced, double-stranded RNA-activated protein kinase [Source:NCBI gene;Acc:100144382]) HSP 1 Score: 116.316 bits (290), Expect = 6.824e-27 Identity = 78/212 (36.79%), Postives = 115/212 (54.25%), Query Frame = 2 Query: 1013 LYIQMEFCHL-NLQDWLCNRNKLVSTLQDSDFK-EVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQN 1642 LYIQME C L+DW+ ++N+ LQ + E +A Q++ GVEYIHSN +IHRD+KPANI + D ++KIGDFGL D DE R + TGT Y APE +G +Y K D++++G+I EL+ K T E + E+ + +ET+P E +++L+ KP++R EA+ + + E VQN Sbjct: 414 LYIQMELCRSETLKDWIKDKNR--KDLQAYQRRGESLPIALQIISGVEYIHSNGLIHRDLKPANIMFGM----DNKVKIGDFGLVTTEAVD--DEKRMAR-----SKTGTKVYMAPEQTSG-----NYGQKVDMFALGLIFFELLWKLWTGHERVQIWENARRKKFPAQFLETFPEESLIIKSLLCEKPDDRLEATAVKAEL----EKFVQN 603 HSP 2 Score: 56.6102 bits (135), Expect = 5.184e-8 Identity = 29/72 (40.28%), Postives = 44/72 (61.11%), Query Frame = 2 Query: 398 DFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFE 613 ++D + IGKGGFGRVY N++ + YA+K I++ ++ ++E + LAKL H NIVRY+ W E Sbjct: 328 EYDILGRIGKGGFGRVYKVRNRLINREYAVK--IVSGTEKAKQEAS-------TLAKLQHDNIVRYYIAWME 390
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Planmine SMEST
Match: SMESG000020439.1 (SMESG000020439.1) HSP 1 Score: 1075.08 bits (2779), Expect = 0.000e+0 Identity = 542/548 (98.91%), Postives = 545/548 (99.45%), Query Frame = 2 Query: 113 MTFNLINAPCLEMDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQQKQH 1756 MTFNLINAPCLEMDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIP+ISHSSSFTNNSSVICSTSMSFNGSNVS+LTNNSAFNTGSLSHSI D SNIDT+NSDCRHS SNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQQKQH Sbjct: 1 MTFNLINAPCLEMDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPRISHSSSFTNNSSVICSTSMSFNGSNVSNLTNNSAFNTGSLSHSICDPSNIDTRNSDCRHSDSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQQKQH 548
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Planmine SMEST
Match: SMESG000020439.1 (SMESG000020439.1) HSP 1 Score: 1048.88 bits (2711), Expect = 0.000e+0 Identity = 530/536 (98.88%), Postives = 533/536 (99.44%), Query Frame = 2 Query: 149 MDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQQKQH 1756 MDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIP+ISHSSSFTNNSSVICSTSMSFNGSNVS+LTNNSAFNTGSLSHSI D SNIDT+NSDCRHS SNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQQKQH Sbjct: 1 MDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLVISVDIFKKCFGDNFISPNFIQNSISFVQNFKPIKFQFKVNQLINDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPRISHSSSFTNNSSVICSTSMSFNGSNVSNLTNNSAFNTGSLSHSICDPSNIDTRNSDCRHSDSNIIFEYSSNFNHKHDSLTSHSSEDKGALEICKSSNVNVPKMEFALYIQMEFCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLIETWPLEDQHVRNLISNKPENRPEASFILNQTCCFKESIVQNGLYNHIKDIMSENSKLKSENELLRKTLDDLRLSQQKQH 536
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Planmine SMEST
Match: SMESG000032678.1 (SMESG000032678.1) HSP 1 Score: 122.094 bits (305), Expect = 3.884e-29 Identity = 120/422 (28.44%), Postives = 193/422 (45.73%), Query Frame = 2 Query: 395 NDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHS-SEDKGALEICKSSNVNVPKM---EFALYIQME-FCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMK---------LTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLI-ETWPLEDQHVRNLISNKPENRPEASFILN 1606 D++ I+ +GKG FG V+ A +++D YA+K+V + S ++ VK F A L H IVRY+ WFE E W + + Y + + +S SS + S ST + S+ S + + + SL I+DRS + SGS + S+T+ S + GAL ++N M LYI M + +L+DWL + +T + RCL Q++ V Y+HSN ++HRD+KP+NI ++I DFGL+ K + + + LT+N GT Y +PE + + YD K D++S+G+I +ELMV ST E VV ++ + F+ + +++P E + L++ P+ RP I N Sbjct: 120 TDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAF---AHLEHPGIVRYYQAWFELPPEG-WQERKDKEMGLCNLYDDDM-SVSSSSDQSREISNQDSTRCTATNSDWSKFSILAEGDQDSLI--IFDRSAVAP-------SGSESV------------SMTNRSVAPASGALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTT-----RCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILF----DNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPE---QQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERA-VVLTKARRMQFEPWVTDSFPREVEFACRLLNPDPDKRPTCEQIFN 502
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Planmine SMEST
Match: SMESG000032681.1 (SMESG000032681.1) HSP 1 Score: 113.235 bits (282), Expect = 3.931e-26 Identity = 114/399 (28.57%), Postives = 183/399 (45.86%), Query Frame = 2 Query: 395 NDFDSIKPIGKGGFGRVYSAVNKIDCQIYAIKQVIINCSKLNEKEIADTVKEFRILAKLNHGNIVRYHTVWFERFEEANWNSQVENFTNCSGSYANSIPKIXXXXXXXXXXXXXXXTSMSFNGSNVSSLTNNSAFNTGSLSHSIYDRSNIDTQNSDCRHSGSNIIFEYSSNFNHKHDSLTSHS-SEDKGALEICKSSNVNVPKM---EFALYIQME-FCHLNLQDWLCNRNKLVSTLQDSDFKEVRCLAR---QLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFDKCDEISSIRKMK---------LTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVKFSTQSELCHVVEDISKGIGFKDLI-ETWPLE 1537 D++ I+ +GKG FG V+ A +++D YA+K+V + S ++ VK F A L H IVRY+ WFE E W + + Y + + +S SS + S ST + S+ S + + + SL I+DRS + SGS + S+T+ S + GAL ++N M LYI M + +L+DWL + +T + RCL Q++ V Y+HSN ++HRD+KP+NI ++I DFGL+ K + + + LT+N GT Y +PE + + YD K D++S+G+I +ELMV ST E VV ++ + F+ + +++P E Sbjct: 120 TDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAF---AHLEHPGIVRYYQAWFELPPEG-WQERKDKEMGLCNLYDDDM-SVSSSSDQSREISNQDSTRCTATNSDWSKFSILAEGDQDSLI--IFDRSAVAP-------SGSESV------------SMTNRSVAPASGALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTT-----RCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILF----DNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPE---QQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERA-VVLTKARRMQFEPWVTDSFPRE 479
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Planmine SMEST
Match: SMESG000021704.1 (SMESG000021704.1) HSP 1 Score: 84.7297 bits (208), Expect = 9.941e-18 Identity = 55/140 (39.29%), Postives = 80/140 (57.14%), Query Frame = 2 Query: 1112 VRCLARQLLKGVEYIHSNNVIHRDIKPANIFLIIHPSKDIQLKIGDFGLSKFFEFD-KCDEISS--IRKMKLTANTGTAFYSAPEVFNGKCKRISYDHKSDLYSVGMILLELMVK--FSTQSELCHVVEDISKGIGFKDL 1516 +R QLL GV YIHS +VIHRD+KPANI + + + LKI DFG+++ + KCD S + + LT T +Y APE+ G+ +SYD K DL+S G IL EL +K + + +++I K +G D+ Sbjct: 133 IRYFMYQLLCGVNYIHSASVIHRDLKPANILI----NSNCHLKIADFGMARLLTPNIKCDRKFSENVLNLNLTQYVMTRWYRAPELLMGQ---LSYDMKIDLWSCGCILAELFLKKPLFRGDNMINQLKEIIKKMGTPDV 265 The following BLAST results are available for this feature:
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003352 ID=SMED30003352|Name=Eukaryotic translation initiation factor 2-alpha kinase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1829bpback to top protein sequence of SMED30003352-orf-1 >SMED30003352-orf-1 ID=SMED30003352-orf-1|Name=SMED30003352-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=549bp MTFNLINAPCLEMDGNFWTKATKVCNFYVIDNNVIISNTSDNAEEKTKLLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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