Non-specific serine/threonine protein kinase

Overview
NameNon-specific serine/threonine protein kinase
Smed IDSMED30003323
Length (bp)4221
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Non-specific serine/threonine protein kinase (SMED30003323) t-SNE clustered cells

Violin plots show distribution of expression levels for Non-specific serine/threonine protein kinase (SMED30003323) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Non-specific serine/threonine protein kinase (SMED30003323) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Non-specific serine/threonine protein kinase (SMED30003323) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30003323

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30003323SMESG000042362.1 dd_Smed_v4_5124_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30003323SMESG000042362.1 dd_Smed_v4_5124_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30003323SMESG000042362.1 dd_Smed_v4_5124_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30003323SMESG000042362.1 dd_Smed_v4_5124_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30003323SMESG000042362.1 dd_Smed_v4_5124_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 501.901 bits (1291), Expect = 1.447e-160
Identity = 241/392 (61.48%), Postives = 304/392 (77.55%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLW--ENGMPKPSTKPNQNTI-VPNYLNNRPQPNFXXXXXXXXXXXVAIPEM---PALAKTQYTTQDISRNAISHNRSQSS 1641
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR+KFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+   KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL   ++   +PS+  N +T   P++   R   +  +    S     AIP +   P  ++T     D+  + IS  +S  S
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSEVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGS 442

HSP 2 Score: 98.5969 bits (244), Expect = 4.179e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  612 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 707
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 498.049 bits (1281), Expect = 7.184e-159
Identity = 224/313 (71.57%), Postives = 272/313 (86.90%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR+KFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+   KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.5969 bits (244), Expect = 4.133e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  628 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 723
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 497.664 bits (1280), Expect = 1.411e-158
Identity = 224/313 (71.57%), Postives = 272/313 (86.90%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR+KFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+   KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.5969 bits (244), Expect = 4.437e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  643 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 738
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 497.278 bits (1279), Expect = 2.755e-158
Identity = 224/313 (71.57%), Postives = 272/313 (86.90%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR+KFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+   KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.2117 bits (243), Expect = 4.997e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  652 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 747
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK4 (microtubule affinity regulating kinase 4 [Source:HGNC Symbol;Acc:HGNC:13538])

HSP 1 Score: 492.271 bits (1266), Expect = 3.474e-157
Identity = 221/313 (70.61%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L+R IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAV YCHQK IVHRDLKAENLLLD + +IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVD+WSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYR+PFYMS+DCE++LR+ LVLNP +R  L  IMKD WIN+GYE   L+P+ EPE D+ D  +I+V++ MG+T ++I ESL  ++Y+ +TA YLL
Sbjct:   54 PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLL 366
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 474.937 bits (1221), Expect = 8.918e-148
Identity = 219/313 (69.97%), Postives = 267/313 (85.30%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLL---SMGFTLQQITESLQQKRYDSITAIYLL 1422
            GKYKL++ IGKGNFAKVKLA+H+ITG EVA+KIIDKT LN  +LQKL REVKIMK+L+HPNIV+LY+V++TE++LYLV+E A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQY H K I+HRDLKAENLLLD+D++IKIADFGFSN FS  +KL+TFCGSPPYAAPELF G++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K LV+NPQRR  L +IMKD W+NVGYE+  L+PF EP  D  D+ +I+ L+    +GF    I ES+++++++ I A YLL
Sbjct:  104 GKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLL 416
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 474.937 bits (1221), Expect = 8.918e-148
Identity = 219/313 (69.97%), Postives = 267/313 (85.30%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLL---SMGFTLQQITESLQQKRYDSITAIYLL 1422
            GKYKL++ IGKGNFAKVKLA+H+ITG EVA+KIIDKT LN  +LQKL REVKIMK+L+HPNIV+LY+V++TE++LYLV+E A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQY H K I+HRDLKAENLLLD+D++IKIADFGFSN FS  +KL+TFCGSPPYAAPELF G++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K LV+NPQRR  L +IMKD W+NVGYE+  L+PF EP  D  D+ +I+ L+    +GF    I ES+++++++ I A YLL
Sbjct:  104 GKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLL 416
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 474.937 bits (1221), Expect = 8.918e-148
Identity = 219/313 (69.97%), Postives = 267/313 (85.30%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLL---SMGFTLQQITESLQQKRYDSITAIYLL 1422
            GKYKL++ IGKGNFAKVKLA+H+ITG EVA+KIIDKT LN  +LQKL REVKIMK+L+HPNIV+LY+V++TE++LYLV+E A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQY H K I+HRDLKAENLLLD+D++IKIADFGFSN FS  +KL+TFCGSPPYAAPELF G++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K LV+NPQRR  L +IMKD W+NVGYE+  L+PF EP  D  D+ +I+ L+    +GF    I ES+++++++ I A YLL
Sbjct:  104 GKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLL 416
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 474.937 bits (1221), Expect = 8.918e-148
Identity = 219/313 (69.97%), Postives = 267/313 (85.30%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLL---SMGFTLQQITESLQQKRYDSITAIYLL 1422
            GKYKL++ IGKGNFAKVKLA+H+ITG EVA+KIIDKT LN  +LQKL REVKIMK+L+HPNIV+LY+V++TE++LYLV+E A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQY H K I+HRDLKAENLLLD+D++IKIADFGFSN FS  +KL+TFCGSPPYAAPELF G++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K LV+NPQRR  L +IMKD W+NVGYE+  L+PF EP  D  D+ +I+ L+    +GF    I ES+++++++ I A YLL
Sbjct:  104 GKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLL 416
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 474.937 bits (1221), Expect = 8.918e-148
Identity = 219/313 (69.97%), Postives = 267/313 (85.30%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLL---SMGFTLQQITESLQQKRYDSITAIYLL 1422
            GKYKL++ IGKGNFAKVKLA+H+ITG EVA+KIIDKT LN  +LQKL REVKIMK+L+HPNIV+LY+V++TE++LYLV+E A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQY H K I+HRDLKAENLLLD+D++IKIADFGFSN FS  +KL+TFCGSPPYAAPELF G++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K LV+NPQRR  L +IMKD W+NVGYE+  L+PF EP  D  D+ +I+ L+    +GF    I ES+++++++ I A YLL
Sbjct:  104 GKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLL 416
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0301505)

HSP 1 Score: 497.664 bits (1280), Expect = 8.808e-158
Identity = 224/311 (72.03%), Postives = 265/311 (85.21%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
             GKYKLI+ IGKGNFAKVKLA+HL TGKEVA+KIIDKT+LN  +LQKL REV+IMK L+HPNIV+L++VI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR KFRQIVSAVQYCHQK I+HRDLKAENLLLD +L+IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG TLRELRERVLRGKYRIPFYMS+DCE LLRK LVLNP +R  L  IM D W+N+G+EE  L+P+ EP+ D  D  +I+ L++MG+   +I  SL Q RYD + A YLL
Sbjct:  250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLL 560
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0330243)

HSP 1 Score: 497.664 bits (1280), Expect = 1.039e-157
Identity = 224/311 (72.03%), Postives = 265/311 (85.21%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
             GKYKLI+ IGKGNFAKVKLA+HL TGKEVA+KIIDKT+LN  +LQKL REV+IMK L+HPNIV+L++VI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR KFRQIVSAVQYCHQK I+HRDLKAENLLLD +L+IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG TLRELRERVLRGKYRIPFYMS+DCE LLRK LVLNP +R  L  IM D W+N+G+EE  L+P+ EP+ D  D  +I+ L++MG+   +I  SL Q RYD + A YLL
Sbjct:  250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLL 560
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0100390)

HSP 1 Score: 496.893 bits (1278), Expect = 2.020e-157
Identity = 224/311 (72.03%), Postives = 265/311 (85.21%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
             GKYKLI+ IGKGNFAKVKLA+HL TGKEVA+KIIDKT+LN  +LQKL REV+IMK L+HPNIV+L++VI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR KFRQIVSAVQYCHQK I+HRDLKAENLLLD +L+IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG TLRELRERVLRGKYRIPFYMS+DCE LLRK LVLNP +R  L  IM D W+N+G+EE  L+P+ EP+ D  D  +I+ L++MG+   +I  SL Q RYD + A YLL
Sbjct:  250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLL 560
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0086450)

HSP 1 Score: 494.197 bits (1271), Expect = 4.312e-155
Identity = 224/311 (72.03%), Postives = 265/311 (85.21%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
             GKYKLI+ IGKGNFAKVKLA+HL TGKEVA+KIIDKT+LN  +LQKL REV+IMK L+HPNIV+L++VI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR KFRQIVSAVQYCHQK I+HRDLKAENLLLD +L+IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG TLRELRERVLRGKYRIPFYMS+DCE LLRK LVLNP +R  L  IM D W+N+G+EE  L+P+ EP+ D  D  +I+ L++MG+   +I  SL Q RYD + A YLL
Sbjct:  250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLL 560

HSP 2 Score: 92.8189 bits (229), Expect = 1.307e-18
Identity = 42/94 (44.68%), Postives = 62/94 (65.96%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR  RF++  + TS   PD++M +I+ VL   + DYEQR  FVL C++G+   ++++ WE+EV +L   SLNG+RFKR+ G  I  K I+ RI
Sbjct:  839 KPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRI 932
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0086457)

HSP 1 Score: 493.041 bits (1268), Expect = 4.256e-154
Identity = 224/311 (72.03%), Postives = 265/311 (85.21%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
             GKYKLI+ IGKGNFAKVKLA+HL TGKEVA+KIIDKT+LN  +LQKL REV+IMK L+HPNIV+L++VI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR KFRQIVSAVQYCHQK I+HRDLKAENLLLD +L+IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG TLRELRERVLRGKYRIPFYMS+DCE LLRK LVLNP +R  L  IM D W+N+G+EE  L+P+ EP+ D  D  +I+ L++MG+   +I  SL Q RYD + A YLL
Sbjct:  373 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLL 683
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark3a (MAP/microtubule affinity-regulating kinase 3a [Source:ZFIN;Acc:ZDB-GENE-030131-6232])

HSP 1 Score: 490.345 bits (1261), Expect = 2.765e-159
Identity = 224/313 (71.57%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG EVA+K+IDKT+LN  +LQKL+REV IMK LNHPNIV+L+EVI+TE++L+LVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F   SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMK+ WIN G+E+  L+PF EP+ D +DQ +IDV++ MGF+ ++I ESL +  YD +TAIYLL
Sbjct:   52 PVIGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFEDDELKPFTEPDADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLL 364
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark3b (MAP/microtubule affinity-regulating kinase 3b [Source:ZFIN;Acc:ZDB-GENE-060929-80])

HSP 1 Score: 496.123 bits (1276), Expect = 5.704e-158
Identity = 225/313 (71.88%), Postives = 272/313 (86.90%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+T+++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGCEEEELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDEITATYLL 363

HSP 2 Score: 101.679 bits (252), Expect = 3.005e-21
Identity = 44/95 (46.32%), Postives = 65/95 (68.42%), Query Frame = 1 
Query: 3352 TKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
             KPR+ RF++  + TS   P E+M EI++VL A + DYEQR  F+L+C++G+   E+++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  654 AKPRSLRFTWSMKTTSSMEPTEMMREIRKVLDANNCDYEQRERFLLLCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 748
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark3a (MAP/microtubule affinity-regulating kinase 3a [Source:ZFIN;Acc:ZDB-GENE-030131-6232])

HSP 1 Score: 494.197 bits (1271), Expect = 1.119e-157
Identity = 224/313 (71.57%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG EVA+K+IDKT+LN  +LQKL+REV IMK LNHPNIV+L+EVI+TE++L+LVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F   SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMK+ WIN G+E+  L+PF EP+ D +DQ +IDV++ MGF+ ++I ESL +  YD +TAIYLL
Sbjct:   52 PVIGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFEDDELKPFTEPDADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLL 364

HSP 2 Score: 87.4261 bits (215), Expect = 7.269e-17
Identity = 39/94 (41.49%), Postives = 61/94 (64.89%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++    TS   P +++ EI+ VL A    Y+QR  F+L+C +G++  ++++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  623 KPRSLRFTWSMNTTSTMEPADIINEIRTVLDANSCSYQQRECFLLLCAHGDSHTDSLVQWEMEVCKLPRLSLNGVRFKRISGNSIAFKNIASKI 716
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark3a (MAP/microtubule affinity-regulating kinase 3a [Source:ZFIN;Acc:ZDB-GENE-030131-6232])

HSP 1 Score: 494.197 bits (1271), Expect = 1.938e-157
Identity = 224/313 (71.57%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG EVA+K+IDKT+LN  +LQKL+REV IMK LNHPNIV+L+EVI+TE++L+LVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F   SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMK+ WIN G+E+  L+PF EP+ D +DQ +IDV++ MGF+ ++I ESL +  YD +TAIYLL
Sbjct:   52 PVIGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFEDDELKPFTEPDADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLL 364

HSP 2 Score: 87.4261 bits (215), Expect = 7.954e-17
Identity = 39/94 (41.49%), Postives = 61/94 (64.89%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++    TS   P +++ EI+ VL A    Y+QR  F+L+C +G++  ++++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  638 KPRSLRFTWSMNTTSTMEPADIINEIRTVLDANSCSYQQRECFLLLCAHGDSHTDSLVQWEMEVCKLPRLSLNGVRFKRISGNSIAFKNIASKI 731
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark3a (MAP/microtubule affinity-regulating kinase 3a [Source:ZFIN;Acc:ZDB-GENE-030131-6232])

HSP 1 Score: 493.812 bits (1270), Expect = 2.282e-157
Identity = 224/313 (71.57%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG EVA+K+IDKT+LN  +LQKL+REV IMK LNHPNIV+L+EVI+TE++L+LVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F   SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMK+ WIN G+E+  L+PF EP+ D +DQ +IDV++ MGF+ ++I ESL +  YD +TAIYLL
Sbjct:   52 PVIGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFEDDELKPFTEPDADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLL 364

HSP 2 Score: 87.4261 bits (215), Expect = 7.557e-17
Identity = 39/94 (41.49%), Postives = 61/94 (64.89%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++    TS   P +++ EI+ VL A    Y+QR  F+L+C +G++  ++++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  632 KPRSLRFTWSMNTTSTMEPADIINEIRTVLDANSCSYQQRECFLLLCAHGDSHTDSLVQWEMEVCKLPRLSLNGVRFKRISGNSIAFKNIASKI 725
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:100329119])

HSP 1 Score: 500.36 bits (1287), Expect = 1.473e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 100.138 bits (248), Expect = 1.274e-20
Identity = 43/96 (44.79%), Postives = 66/96 (68.75%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            ++KPR+ RF++  + TS   P+++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  639 ESKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 734
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:100329119])

HSP 1 Score: 499.975 bits (1286), Expect = 2.170e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 100.138 bits (248), Expect = 1.341e-20
Identity = 43/96 (44.79%), Postives = 66/96 (68.75%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            ++KPR+ RF++  + TS   P+++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  648 ESKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 743
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:100329119])

HSP 1 Score: 500.36 bits (1287), Expect = 3.211e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 99.7525 bits (247), Expect = 1.859e-20
Identity = 43/96 (44.79%), Postives = 66/96 (68.75%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            ++KPR+ RF++  + TS   P+++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  668 ESKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 763
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:100329119])

HSP 1 Score: 500.36 bits (1287), Expect = 3.903e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 99.3673 bits (246), Expect = 2.201e-20
Identity = 43/96 (44.79%), Postives = 66/96 (68.75%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            ++KPR+ RF++  + TS   P+++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  677 ESKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 772
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: mark2 (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:594939])

HSP 1 Score: 490.73 bits (1262), Expect = 1.771e-155
Identity = 220/313 (70.29%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TGKEVAVKIIDKT+LN+ +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK+IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K L+LNP +R  L  IM+D W+NVG+EE  L+P+ EP  DY D  + +++++MG+T ++I++SL  ++Y+ + A YLL
Sbjct:   59 PHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEEDELKPYVEPIPDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLL 371

HSP 2 Score: 87.8113 bits (216), Expect = 7.907e-17
Identity = 38/95 (40.00%), Postives = 63/95 (66.32%), Query Frame = 1 
Query: 3352 TKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            +KPR+ RF++  + TS   P+E+M+EI++VL A +  +E +  ++L+C++G    +  + WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  683 SKPRSLRFTWSMKTTSSMEPNEMMSEIRKVLDANNCQHESQEKYMLLCVHGTPGHDNYVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 777
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark3 (MAP/microtubule affinity regulating kinase 3 [Source:MGI Symbol;Acc:MGI:1341865])

HSP 1 Score: 500.36 bits (1287), Expect = 7.492e-160
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.5969 bits (244), Expect = 3.066e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  628 EAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 723
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark3 (MAP/microtubule affinity regulating kinase 3 [Source:MGI Symbol;Acc:MGI:1341865])

HSP 1 Score: 500.745 bits (1288), Expect = 8.821e-160
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.5969 bits (244), Expect = 2.918e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  643 EAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 738
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark3 (MAP/microtubule affinity regulating kinase 3 [Source:MGI Symbol;Acc:MGI:1341865])

HSP 1 Score: 499.975 bits (1286), Expect = 1.934e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.2117 bits (243), Expect = 3.344e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  652 EAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 747
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark3 (MAP/microtubule affinity regulating kinase 3 [Source:MGI Symbol;Acc:MGI:1341865])

HSP 1 Score: 500.36 bits (1287), Expect = 6.002e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.5969 bits (244), Expect = 3.179e-20
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  696 EAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 791
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark4 (MAP/microtubule affinity regulating kinase 4 [Source:MGI Symbol;Acc:MGI:1920955])

HSP 1 Score: 491.115 bits (1263), Expect = 6.935e-157
Identity = 220/313 (70.29%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L+R IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAV YCHQK IVHRDLKAENLLLD + +IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVD+WSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYR+PFYMS+DCE++LR+ LVLNP +R  L  IMKD WIN+GYE   L+P+ EPE D+ D  +I+V++ MG+T ++I E+L  ++Y+ +TA YLL
Sbjct:   54 PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLL 366
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q03141|MARK3_MOUSE (MAP/microtubule affinity-regulating kinase 3 OS=Mus musculus OX=10090 GN=Mark3 PE=1 SV=2)

HSP 1 Score: 499.975 bits (1286), Expect = 1.353e-158
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.2117 bits (243), Expect = 2.339e-19
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  652 EAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 747
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q8VHF0|MARK3_RAT (MAP/microtubule affinity-regulating kinase 3 OS=Rattus norvegicus OX=10116 GN=Mark3 PE=1 SV=1)

HSP 1 Score: 498.819 bits (1283), Expect = 1.298e-157
Identity = 225/313 (71.88%), Postives = 272/313 (86.90%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKI DFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKITDFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEEELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.9821 bits (245), Expect = 1.634e-19
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A   DYEQR  F+L C++G+   E+++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  696 EAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANTCDYEQRERFLLFCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 791
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|P27448|MARK3_HUMAN (MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5)

HSP 1 Score: 497.278 bits (1279), Expect = 1.323e-157
Identity = 224/313 (71.57%), Postives = 272/313 (86.90%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+AR+KFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+   KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363

HSP 2 Score: 98.2117 bits (243), Expect = 2.400e-19
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  652 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 747
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|O08679|MARK2_RAT (Serine/threonine-protein kinase MARK2 OS=Rattus norvegicus OX=10116 GN=Mark2 PE=1 SV=1)

HSP 1 Score: 488.804 bits (1257), Expect = 9.525e-155
Identity = 222/313 (70.93%), Postives = 271/313 (86.58%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TGKEVAVKIIDKT+LN+ +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K L+LNP +R  L  IMKD W+NVG+E+  L+P+ EP  DY D  + ++++SMG+T ++I +SL  +RY+ + A YLL
Sbjct:   48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 360

HSP 2 Score: 83.5741 bits (205), Expect = 8.945e-15
Identity = 38/96 (39.58%), Postives = 59/96 (61.46%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P+E+M EI++VL A     E    ++L+C++G    E  + WEMEV +L   SLNG+RFKR+ G  +  K I+ +I
Sbjct:  621 EAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKI 716
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q96L34|MARK4_HUMAN (MAP/microtubule affinity-regulating kinase 4 OS=Homo sapiens OX=9606 GN=MARK4 PE=1 SV=1)

HSP 1 Score: 489.574 bits (1259), Expect = 1.097e-154
Identity = 221/313 (70.61%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L+R IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAV YCHQK IVHRDLKAENLLLD + +IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVD+WSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYR+PFYMS+DCE++LR+ LVLNP +R  L  IMKD WIN+GYE   L+P+ EPE D+ D  +I+V++ MG+T ++I ESL  ++Y+ +TA YLL
Sbjct:   54 PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLL 366

HSP 2 Score: 59.6918 bits (143), Expect = 1.991e-7
Identity = 32/102 (31.37%), Postives = 56/102 (54.90%), Query Frame = 1 
Query: 3334 PTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTG-EAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            P ++ +T PR  RF +  ++TS + P+ LMA +++   A      Q   F+L C++G   G E + H+E+EV +L    L G+ F+R+ G  +  + +  RI
Sbjct:  645 PWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRI 746
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A172RVS0 (Non-specific serine/threonine protein kinase (Fragment) OS=Schmidtea mediterranea OX=79327 GN=TSSK PE=2 SV=1)

HSP 1 Score: 2104.72 bits (5452), Expect = 0.000e+0
Identity = 1151/1183 (97.30%), Postives = 1152/1183 (97.38%), Query Frame = 1 
Query:  103 MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINPSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNXXXXXXXXXXXXXXXXXXXXXXXXERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFXXXXXXXXXXXVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPXXXXXXXXXXXXXPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEM---EVSEKESDELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKXXXXXXXXXXXXXXXIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQXXXXXXXXXXXXXXXXXXXLTTKISKKQASQVDDVDIRPTLWMRHATTHEKLXXXXXXXXXXXXXQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLIXXXXXXXXXXXXXXIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE 3642
            MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINPSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNGTSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSNGPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEM   E   + S ELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSLTTKISKK                       KLSNPSPSINRSPSNQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE
Sbjct:    1 MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINPSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNGTSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSNGPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEMEVSEKESEISSELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSLTTKISKK-----------------------KLSNPSPSINRSPSNQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE 1160
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A0D9RCG9 (Microtubule affinity regulating kinase 3 OS=Chlorocebus sabaeus OX=60711 GN=MARK3 PE=4 SV=1)

HSP 1 Score: 499.59 bits (1285), Expect = 3.786e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLL 363
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A3B5LCQ5 (Microtubule affinity regulating kinase 3 OS=Xiphophorus couchianus OX=32473 GN=MARK3 PE=3 SV=1)

HSP 1 Score: 497.664 bits (1280), Expect = 4.823e-159
Identity = 234/346 (67.63%), Postives = 284/346 (82.08%), Query Frame = 1 
Query:  472 ERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPN 1509
            E   P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TER+LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+P+ EPE+D  DQ +IDV++ MG+ L++I +SL + +YD ITA YLL   G      +P+ +    N    +P+PN
Sbjct:   30 ESQQPHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETERTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINSGFEEDELKPYTEPELDITDQKRIDVMVGMGYNLEEIQDSLAKMKYDEITATYLLL--GRKASELEPSDSASSSNLSLAKPRPN 373
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: H9YXQ1 (Non-specific serine/threonine protein kinase OS=Macaca mulatta OX=9544 GN=MARK3 PE=2 SV=1)

HSP 1 Score: 504.982 bits (1299), Expect = 1.349e-158
Identity = 243/392 (61.99%), Postives = 305/392 (77.81%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLW--ENGMPKPSTKPNQNTI-VPNYLNNRPQPNFXXXXXXXXXXXVAIPEM---PALAKTQYTTQDISRNAISHNRSQSS 1641
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL   ++   +PS+  N +T   P++   R   +  +    S     AIP +   P  ++T     D+  + IS  +S  S
Sbjct:   51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSEVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGS 442

HSP 2 Score: 98.5969 bits (244), Expect = 5.897e-17
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  612 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 707
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A1U7T1S4 (Non-specific serine/threonine protein kinase OS=Tarsius syrichta OX=1868482 GN=MARK3 PE=4 SV=1)

HSP 1 Score: 504.982 bits (1299), Expect = 1.364e-158
Identity = 243/389 (62.47%), Postives = 305/389 (78.41%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLW--ENGMPKPSTKPNQNTI-VPNYLNNRPQPNFXXXXXXXXXXXVAIPEM---PALAKTQYTTQDISRNAISHNRS 1632
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYL+ME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL   ++   +PS+  N +T   P++   R   +  +    S     AIP +   P  ++T  T  D+  + IS  +S
Sbjct:   50 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLGKMKYDEITATYLLLGRKSSEVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTTDSDLKEDGISSRKS 438

HSP 2 Score: 98.5969 bits (244), Expect = 5.540e-17
Identity = 43/96 (44.79%), Postives = 64/96 (66.67%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            + KPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L C++G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  611 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 706
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark3b (MAP/microtubule affinity-regulating kinase 3 [Source:NCBI gene;Acc:103043586])

HSP 1 Score: 499.204 bits (1284), Expect = 3.718e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   63 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGFEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDEITATYLL 375

HSP 2 Score: 101.293 bits (251), Expect = 3.053e-21
Identity = 44/95 (46.32%), Postives = 66/95 (69.47%), Query Frame = 1 
Query: 3352 TKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            TKPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L+C++G+   E+++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  664 TKPRSLRFTWSMKTTSAMEPTDMMREIRKVLDANNCDYEQRERFLLLCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 758
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark3b (MAP/microtubule affinity-regulating kinase 3 [Source:NCBI gene;Acc:103043586])

HSP 1 Score: 500.745 bits (1288), Expect = 4.413e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   63 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGFEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDEITATYLL 375

HSP 2 Score: 101.679 bits (252), Expect = 2.497e-21
Identity = 44/95 (46.32%), Postives = 66/95 (69.47%), Query Frame = 1 
Query: 3352 TKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            TKPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L+C++G+   E+++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  709 TKPRSLRFTWSMKTTSAMEPTDMMREIRKVLDANNCDYEQRERFLLLCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 803
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 495.738 bits (1275), Expect = 4.662e-159
Identity = 225/317 (70.98%), Postives = 271/317 (85.49%), Query Frame = 1 
Query:  472 ERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            E   P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++L+LVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IM+D WIN G EE  L+P+ EPE D +DQ +IDV++ MG++  +I ESL + +YD ITA YLL
Sbjct:   48 EEQHPHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWINAGSEEEELKPYTEPETDISDQKRIDVMVGMGYSRDEIQESLSKMKYDEITATYLL 364
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark3b (MAP/microtubule affinity-regulating kinase 3 [Source:NCBI gene;Acc:103043586])

HSP 1 Score: 500.36 bits (1287), Expect = 4.735e-159
Identity = 226/313 (72.20%), Postives = 273/313 (87.22%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+PF EPE+D +DQ +ID+++ MG++ ++I ESL + +YD ITA YLL
Sbjct:   63 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGFEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDEITATYLL 375

HSP 2 Score: 101.679 bits (252), Expect = 2.360e-21
Identity = 44/95 (46.32%), Postives = 66/95 (69.47%), Query Frame = 1 
Query: 3352 TKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            TKPR+ RF++  + TS   P ++M EI++VL A + DYEQR  F+L+C++G+   E+++ WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  700 TKPRSLRFTWSMKTTSAMEPTDMMREIRKVLDANNCDYEQRERFLLLCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 794
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:103040919])

HSP 1 Score: 495.352 bits (1274), Expect = 1.451e-158
Identity = 225/317 (70.98%), Postives = 271/317 (85.49%), Query Frame = 1 
Query:  472 ERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            E   P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++L+LVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IM+D WIN G EE  L+P+ EPE D +DQ +IDV++ MG++  +I ESL + +YD ITA YLL
Sbjct:   48 EEQHPHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPGKRGTLEQIMRDRWINAGSEEEELKPYTEPETDISDQKRIDVMVGMGYSRDEIQESLSKMKYDEITATYLL 364
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006410.1 (pep scaffold:Pmarinus_7.0:GL476370:17405:31068:-1 gene:ENSPMAG00000005688.1 transcript:ENSPMAT00000006410.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 498.049 bits (1281), Expect = 1.304e-160
Identity = 226/319 (70.85%), Postives = 273/319 (85.58%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMP 1440
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+LYEVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D+ IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRE+VLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IM+D W+NVG+EE  L+P+ EPE+D NDQ +I++++ MG+T+ +I  SL  K+YD I A YLL  N  P
Sbjct:   34 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKCLNHPNIVKLYEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKNIVHRDLKAENLLLDVDMHIKIADFGFSNEFTLVNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELREKVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGSLEQIMRDRWMNVGHEEDELKPYQEPELDINDQKRIEIMIGMGYTMDEIVGSLSAKKYDEIMATYLLLGNKSP 352
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 481.485 bits (1238), Expect = 1.176e-157
Identity = 220/310 (70.97%), Postives = 266/310 (85.81%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            G Y+L++ IGKGNFAKVKLA+H +TG+EVAVKIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+ E++LYLVME +  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVL+P +R  L  IMKD W+NV +E+  L+P+ EP +D  D  +ID ++ MGF  ++IT+SL + +YD ITA YLL
Sbjct:   66 GNYRLLKTIGKGNFAKVKLAKHTLTGQEVAVKIIDKTQLNTSSLQKLFREVRIMKVLNHPNIVKLFEVIEMEKTLYLVMEYSSGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLHPLKRGSLEQIMKDRWMNVKHEDDELKPYLEPSLDIGDTKRIDFMVGMGFAREKITKSLSEMKYDDITATYLL 375
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 486.878 bits (1252), Expect = 1.261e-154
Identity = 222/311 (71.38%), Postives = 266/311 (85.53%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
             G Y+L++ IGKGNFAKVKLA+H +TG+EVAVKIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+TE++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  SKL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD W+NVG+EE  L+P+ EP +D ND  +I+ ++ MG++  +I +SL   +YD I A YLL
Sbjct:   51 IGTYRLLKTIGKGNFAKVKLARHTLTGREVAVKIIDKTQLNPSSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGSLEQIMKDRWMNVGHEEDELKPYVEPTLDINDTKRIETMVEMGYSRDEIRDSLTNMKYDEILATYLL 361

HSP 2 Score: 88.5817 bits (218), Expect = 6.582e-18
Identity = 43/97 (44.33%), Postives = 61/97 (62.89%), Query Frame = 1 
Query: 3352 TKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGE--NTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            +KPR+ RF++  + TS   P E+M EI++VL     DYEQR  ++L C +GE  +  E  + WEMEV +L   SLNG+RFKR+ G  I  K I+ +I
Sbjct:  700 SKPRSLRFTWSMKTTSSMEPGEMMREIRKVLDNNACDYEQREPYLLYCAHGETRSGAEEPVTWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKI 796
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: snrka (SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040718-84])

HSP 1 Score: 256.529 bits (654), Expect = 1.875e-73
Identity = 133/324 (41.05%), Postives = 203/324 (62.65%), Query Frame = 1 
Query:  481 GPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKL-TREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKN-GRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLL-DKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDY-----NDQSKIDVLLSMGFTLQQ--ITESLQQKRYDSITAIYLL 1422
            G   G Y L + +G+G+FA VKLA+H+ TG++VAVK+IDK+KL+  A   L  +EV+ MK + HPN+VRLYEVI T+  LYL++E A  G++++Y++++ G ++E+ A+  F Q+V A+ YCH+  +VHRDLK EN++  +K   +K+ DFGFSN F   +KL T CGS  Y+APE+  G  Y+ P VD+WSLGVILY L+ G  PF      E    ++  KY +P ++S +C+ L+ +ML  +P+RR  L ++    W+  G +  P      P I Y     ++ + I   + +G   ++  I E+L+  RY+ ITA Y L
Sbjct:   10 GKIAGLYDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKSKLDPMATSHLFQQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELADGGDLYDYIMRHEGGLQEELAKTYFAQVVHAISYCHRLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNLFQPGTKLATSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILYMLVCGHPPFQEANDSETLTMIMDCKYTVPAHISRECKDLIARMLQRDPRRRASLQEMEGHPWL-CGVDPSPAAKCSTPLISYKSLSEDEHNGIVQRMVLGSIAERDAIVEALEADRYNHITATYFL 332
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: NIM1K (NIM1 serine/threonine protein kinase [Source:HGNC Symbol;Acc:HGNC:28646])

HSP 1 Score: 232.261 bits (591), Expect = 1.459e-67
Identity = 114/272 (41.91%), Postives = 171/272 (62.87%), Query Frame = 1 
Query:  499 YKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINV-----GYEECPLRPFYEP 1299
            Y++  EIG GNF++VKL  HL+T  +VA+K++DK++++   L  L+ E+  M+ L HPN+VRLYEV+ T   L+LVME A  GE+F  +   G +   +A+  F QI +AV++ H+  +VHRDLKAEN+    +  +K+ DFGFS   +   +L+TFCGSPPYAAPELF+ + Y GP+VDVW+LGV+L+ + SG+LPF   T+ +L+  +L G + +P  + + C  L+  +L   P  R     I++  W+        Y   PL P Y P
Sbjct:   43 YRIRGEIGSGNFSQVKLGVHLLTRDKVAIKLLDKSRMDERTLCLLSCEILAMELLRHPNVVRLYEVVDTPSRLHLVMEYAPGGELFTRVSTVGALPHDEAKLVFAQITAAVKHMHECGVVHRDLKAENVFYAGNCWVKVGDFGFSTTVTPNERLSTFCGSPPYAAPELFRDQSYLGPQVDVWALGVLLFFIASGTLPFRADTVGKLKLSILDGCFSVPLRVPASCCNLITTILRPLPDERPTAAQILRSEWLRGIHAPEPYPPYPLGPRYLP 314
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885])

HSP 1 Score: 269.626 bits (688), Expect = 6.094e-78
Identity = 140/339 (41.30%), Postives = 215/339 (63.42%), Query Frame = 1 
Query:  478 NGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQ-KLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEEC----PLRPFYEPEIDYNDQSK--------------IDVLLS-MGFTLQQITESLQQKR----YDSITAIYLL 1422
            +G   G Y++++ +G+G+F KVKLA H  TG++VA+KII+K  L    +Q ++ RE+  ++ L HP+I++LY+VI+++  + +V+E A N E+F+Y+V+  +M E++AR  F+QI+SAV+YCH+  IVHRDLK ENLLLD+ L++KIADFG SN  +  + L T CGSP YAAPE+  G+ Y GPEVDVWS GVILY ++   LPFD  ++  L + +  G Y +P ++S     L+++ML++NP  R+ + +IM+D W  V   E      L+P  E E + ND  K              +++L S MG+   +I ESL+       ++ I   Y+L
Sbjct:   48 DGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGN-ELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLKPHPEEENENNDSKKDGSSPDNDEIDDNLVNILSSTMGYEKDEIYESLESSEDTPAFNEIRDAYML 385
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: KCC4 (Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication [Source:SGD;Acc:S000000529])

HSP 1 Score: 226.868 bits (577), Expect = 4.522e-61
Identity = 118/264 (44.70%), Postives = 167/264 (63.26%), Query Frame = 1 
Query:  487 TFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQK---------LTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFD--GGTLRELRERVLRGKYRIP--FYMSSDCEALLRKMLVLNPQRRLPLTDIM 1239
            T G +KL   +G G+  KV+LAQH  TG   AVK+I K+  N               + RE+ IMK L+HPN++ LY+V +T  +LYL++E A+ GE+F  LV +G + E++A   FRQI+  + YCH   IVHRDLK ENLLLD   +IKIADFG +   +    L T CGSP YAAPE+  G  YEG   DVWS GVIL+ L++G LPFD   G +R+L  +V +G++ +P    +S D + L+ K+LV++P++R+ + DI+
Sbjct:   17 TIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDIL 280
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: GIN4 (Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication [Source:SGD;Acc:S000002915])

HSP 1 Score: 227.254 bits (578), Expect = 5.601e-61
Identity = 121/271 (44.65%), Postives = 167/271 (61.62%), Query Frame = 1 
Query:  487 TFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQK---------------LTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFD--GGTLRELRERVLRGKYRIPF--YMSSDCEALLRKMLVLNPQRRLPLTDIMK 1242
            T G +KL   +G G+  KV+LA++  TG+E AVK+I K   N   +                 + RE+ IMK LNHPN++RLY+V +T   LYLV+E A+ GE+F  LV+ G + E +A   FRQI+  V YCH   IVHRDLK ENLLLD   +IKIADFG +   +    L T CGSP YAAPE+  G  Y+G   DVWS GVIL+ L++G LPFD   G +R L  +V +G++ +P    +S + + L+RK+L ++P+RR+   DI+K
Sbjct:   15 TIGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILK 285
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: HSL1 (Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p [Source:SGD;Acc:S000001584])

HSP 1 Score: 218.779 bits (556), Expect = 5.966e-58
Identity = 114/302 (37.75%), Postives = 178/302 (58.94%), Query Frame = 1 
Query:  487 TFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTK-----------------------LNAPALQK-------------LTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDK-DLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPL 1281
            T G +KL + +GKG+  +V+LA+++ TG+  A+KI+ K K                       +++P++               + RE+ IMK ++H N++ L+EV + +  LYLV+E    GE+F+YLV  G++ E++A   F+QIV  V YCH   I HRDLK ENLLLDK +  IKIADFG +        L T CGSP YA+PE+  GR Y G   DVWS G++L+ L++G LPF+   +++L  +V  GKY++P  +SS+   L+ K+LV++P++R+   +I+K   I   Y++ P+
Sbjct:   77 TVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIK-KYDDLPV 377
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 212.231 bits (539), Expect = 2.806e-56
Identity = 103/288 (35.76%), Postives = 164/288 (56.94%), Query Frame = 1 
Query:  487 TFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTK---------LNAPA-----------LQK-------LTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYE 1269
            + G ++ +  +G G+  KVKL +H  T +   +KI+++           L +P            L+K         RE  + + L HP+I RL+E+       Y++ E    G++ +Y++++G +KE  AR   R I SA+QY H   IVHRDLK EN+++     IKI DFG SN F  + +L+TFCGS  +AAPEL + + Y GPEVD+WS G++LY L+ G +PFD      L E++ +GK   P ++S +  +LL +M+V++P RR  L ++++  W+N GY+
Sbjct:   95 SLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYD 382
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO30768 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZV3])

HSP 1 Score: 481.1 bits (1237), Expect = 3.583e-154
Identity = 220/313 (70.29%), Postives = 266/313 (84.98%), Query Frame = 1 
Query:  490 FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWE 1428
             G+Y+LI+ IGKGNFAKVKLA+H+ TGKEVA+KIIDKT+LN  +LQKL REV+IMK L+HPNIV+LYEVI+T+++LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK ++HRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL+K LVLNPQ+R  L   M D W+N+ YE   L+P+ EP  + ND+ +ID++L MGFT  +I E+L   RYD + A YLL +
Sbjct:   35 IGRYRLIKTIGKGNFAKVKLAKHVPTGKEVAIKIIDKTQLNPSSLQKLFREVRIMKFLDHPNIVKLYEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHVIHRDLKAENLLLDADMNIKIADFGFSNEFTPGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPQKRARLEQTMTDKWMNINYELNELKPYLEPSAELNDERRIDIMLQMGFTRDEIYEALSNNRYDEVMATYLLLD 347

HSP 2 Score: 84.7297 bits (208), Expect = 1.202e-16
Identity = 39/94 (41.49%), Postives = 59/94 (62.77%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++  + TS   P +++ EI +VL A + DYEQR  ++L+C +G       + WEMEV +L   SLNG+RFKR+ G  I  K I+ ++
Sbjct:  553 KPRSLRFTWSMKTTSTMDPYDMIREIMKVLEANNCDYEQREKYLLLCCHGSPAENNHVQWEMEVCKLPRLSLNGVRFKRISGSSINFKNIASKV 646
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO46035 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR22])

HSP 1 Score: 354.755 bits (909), Expect = 1.196e-111
Identity = 173/323 (53.56%), Postives = 232/323 (71.83%), Query Frame = 1 
Query:  475 RNGPT--FGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWIN--VGYEECPLRPFYEPEIDYNDQSKIDV---LLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            R+G     G Y + + IGKGNFA VKLA H IT  +VAVKIIDK++L+   L K+ REVK+MK+L HP+I++L+EV++TER LYLV E A  GE+F+YLV +GRM+EK+A+  F QIVSA++YCH+  IVHRDLKAENLLLD+D++IKIADFGFSN F    KL T+CGSPPYAAPELF+G+ Y GPEVD+WSLGV+LY L+ G+LPFDG TL+ LR RVL G++RIPF+MS++CE L+R MLV +P +R  +  I +  W+    G +     P Y  E   +   + DV   + +MGF  ++  ++++ K YD    +Y L
Sbjct:   10 RHGSVVRIGFYNIEKTIGKGNFAVVKLATHCITKSKVAVKIIDKSQLDDDNLTKVKREVKVMKKLAHPHIIKLHEVMETERMLYLVTEYASKGEIFDYLVAHGRMQEKEAKNTFNQIVSAIEYCHKMNIVHRDLKAENLLLDEDMNIKIADFGFSNIFQADKKLKTWCGSPPYAAPELFEGKEYLGPEVDIWSLGVVLYVLVCGALPFDGSTLQSLRSRVLDGRFRIPFFMSTECEHLIRHMLVRDPVKRFTIPQIRQHKWMAEVTGKKNKEENPLYIHESCQDVDIREDVIRKMKNMGFDREKTIQAIKNKDYDHNAGVYSL 332
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO31932 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI1])

HSP 1 Score: 321.242 bits (822), Expect = 1.169e-98
Identity = 163/334 (48.80%), Postives = 230/334 (68.86%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIA-----------------DFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWIN------VGYEECPLRPFYEPEI-DYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            G Y++ + IGKGNF+ VKLA+H IT  +VA+KIIDKT+LN   L+K+ REV+IMK L HP+IV+LY+V++T+  LYLV + A NGE+F+YL  +GR+ EK+AR KF QI+SAV YCH++ +VHRDLKAENLLLD++++IKIA                 DFGF N++   + LNT+CGSPPYAAPE      Y  P+VD W LGV+LY L+ G+LPFDG TL+ LR+RVL GK+RIPF+MS++CE L+R MLV +P +R  +  I K  W+       +   E  +R F +  + DYN+Q+ ++++  +G  +++  ++L    +D  TAIY L
Sbjct:   10 GFYEIDKTIGKGNFSVVKLARHRITKSQVAIKIIDKTQLNEMNLKKIYREVQIMKLLQHPHIVKLYQVMETKNMLYLVTDYANNGEMFDYLAHHGRLPEKEARKKFVQILSAVDYCHKRHVVHRDLKAENLLLDQNMNIKIAGMSGLYLVIHCILFSSLDFGFGNYYKPGNPLNTWCGSPPYAAPE----HIYCEPKVDFWPLGVVLYVLVCGALPFDGSTLQALRDRVLEGKFRIPFFMSTECEHLIRHMLVKDPNQRYTIEQIQKHKWLQAADSQKISEIEQSMREFEKISMEDYNEQA-LELMKGLGIDIKRTKKALDDNTFDHHTAIYYL 338
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO36169 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJE6])

HSP 1 Score: 262.307 bits (669), Expect = 6.414e-76
Identity = 135/316 (42.72%), Postives = 195/316 (61.71%), Query Frame = 1 
Query:  478 NGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNA-PALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYN---DQSKIDVLLSMGFTLQQITESLQQKRYDSITAI 1413
            N    G Y L   +G G F KVKLA H +TG +VA+KI+++ K+ +   + K+ RE++ +K   HP+I++LY+VI T   +++VME    GE+FEY++K+G+++EKDAR  F+QI+S V YCH+ M+VHRDLK ENLLLD  L+IKIADFG SN  +    L T CGSP YAAPE+  G+ Y GPEVD+WS GVILY L+ G+LPFD   +  L  ++  G + +P ++SS   +LL  ML ++P +R  +  I +D W      E P   F   E+  N   D+            + Q+ E +  ++ D ITA+
Sbjct:   13 NKLAIGNYNLGETLGVGTFGKVKLAVHQLTGHKVAIKILNRNKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPTDIFMVMEYVSGGELFEYILKHGKLEEKDARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDSQLNIKIADFGLSNIMTDGEFLQTSCGSPNYAAPEVISGKLYAGPEVDIWSAGVILYALLCGTLPFDDEHIPTLFRKIKGGVFHVPPHLSSGPASLLNAMLNVDPIKRATVQFIKEDDWFKT---ELPGYLFPATELGSNVVDDE-----------CMAQVCEKMNCQKGDVITAL 314
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO36587 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SI81])

HSP 1 Score: 246.128 bits (627), Expect = 9.578e-73
Identity = 132/319 (41.38%), Postives = 193/319 (60.50%), Query Frame = 1 
Query:  493 GKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGR-MKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSI-KIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEP---EIDYNDQSKIDVLLSMG----FTLQQITESLQQKRYDSITAIYLL 1422
            G Y L   +G+G+FA VK+A+H+ITG+ VAVK+IDKTKL+  + + L +EV+ MK + HPN+VRLY+VI T   LYL++E    G++++Y++ + + + E+ AR  FRQIV A+ YCH+  +VHRDLK EN++  K+  + K+ DFGFSN+F    KL+T CGS  Y+APE+  G  YE P VDVWSLGVILY L+ G  PF      E   +++  +Y +P ++S  C+ L+ +ML+  P  R  L +IM   W+  G    PL P   P   E+       + +L  M         ++  SL++  YD   A Y L
Sbjct:   17 GMYDLGETLGRGHFAVVKVARHVITGERVAVKVIDKTKLDEVSREHLLKEVRCMKLVQHPNVVRLYQVIDTNTKLYLILELGDGGDMYDYIMNHDKGLPEEKARYFFRQIVLAIDYCHKLHVVHRDLKPENVIFFKNQDMAKLTDFGFSNNFIPNEKLDTACGSLAYSAPEVLLGDAYEAPAVDVWSLGVILYMLVCGQAPFSEANDSETLTKIMDCRYDVPDHVSPLCKNLISRMLIREPHNRASLGEIMSHPWLQQG--PTPLVPSDVPLVAELPLTTDEHLLLLDKMEDGNIADRDKVIRSLEENSYDFTAATYFL 333
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 499.59 bits (1285), Expect = 2.486e-160
Identity = 226/313 (72.20%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+T+R+LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+P+ EPE+D  DQ +IDV++ MG+ L+ I ESL + +YD  TA YLL
Sbjct:   48 PHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINAGFEEDELKPYTEPELDITDQKRIDVMVGMGYKLEDIQESLTKMKYDQFTATYLL 360
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 499.204 bits (1284), Expect = 4.236e-160
Identity = 226/313 (72.20%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+T+R+LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+P+ EPE+D  DQ +IDV++ MG+ L+ I ESL + +YD  TA YLL
Sbjct:   48 PHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINAGFEEDELKPYTEPELDITDQKRIDVMVGMGYKLEDIQESLTKMKYDQFTATYLL 360
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 496.893 bits (1278), Expect = 1.054e-158
Identity = 226/313 (72.20%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+T+R+LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+P+ EPE+D  DQ +IDV++ MG+ L+ I ESL + +YD  TA YLL
Sbjct:   48 PHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINAGFEEDELKPYTEPELDITDQKRIDVMVGMGYKLEDIQESLTKMKYDQFTATYLL 360

HSP 2 Score: 88.5817 bits (218), Expect = 2.359e-17
Identity = 39/94 (41.49%), Postives = 61/94 (64.89%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++    T+   P ++M EI +VL A   +Y+Q+ SF+L+C +G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ ++
Sbjct:  627 KPRSLRFTWSMRTTTSMEPCDIMEEIFKVLDANDCNYKQQESFLLLCFHGDGRAENMVQWEMEVCKLPRLSLNGVRFKRISGSSIAFKNIASKV 720
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 497.278 bits (1279), Expect = 1.280e-158
Identity = 226/313 (72.20%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+T+R+LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+P+ EPE+D  DQ +IDV++ MG+ L+ I ESL + +YD  TA YLL
Sbjct:   48 PHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINAGFEEDELKPYTEPELDITDQKRIDVMVGMGYKLEDIQESLTKMKYDQFTATYLL 360

HSP 2 Score: 88.5817 bits (218), Expect = 2.719e-17
Identity = 39/94 (41.49%), Postives = 61/94 (64.89%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++    T+   P ++M EI +VL A   +Y+Q+ SF+L+C +G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ ++
Sbjct:  642 KPRSLRFTWSMRTTTSMEPCDIMEEIFKVLDANDCNYKQQESFLLLCFHGDGRAENMVQWEMEVCKLPRLSLNGVRFKRISGSSIAFKNIASKV 735
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark3a (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:101163781])

HSP 1 Score: 496.508 bits (1277), Expect = 1.656e-158
Identity = 226/313 (72.20%), Postives = 270/313 (86.26%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLL 1422
            P  G Y+L++ IGKGNFAKVKLA+H++TG+EVA+KIIDKT+LN  +LQKL REV+IMK LNHPNIV+L+EVI+T+R+LYLVME A  GEVF+YLV +GRMKEK+ARAKFRQIVSAVQYCHQK IVHRDLKAENLLLD D++IKIADFGFSN F+  +KL+TFCGSPPYAAPELFQG++Y+GPEVDVWSLGVILYTL+SGSLPFDG  L+ELRERVLRGKYRIPFYMS+DCE LL++ LVLNP +R  L  IMKD WIN G+EE  L+P+ EPE+D  DQ +IDV++ MG+ L+ I ESL + +YD  TA YLL
Sbjct:   48 PHVGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETDRTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINAGFEEDELKPYTEPELDITDQKRIDVMVGMGYKLEDIQESLTKMKYDQFTATYLL 360

HSP 2 Score: 88.5817 bits (218), Expect = 2.838e-17
Identity = 39/94 (41.49%), Postives = 61/94 (64.89%), Query Frame = 1 
Query: 3355 KPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRI 3636
            KPR+ RF++    T+   P ++M EI +VL A   +Y+Q+ SF+L+C +G+   E ++ WEMEV +L   SLNG+RFKR+ G  I  K I+ ++
Sbjct:  636 KPRSLRFTWSMRTTTSMEPCDIMEEIFKVLDANDCNYKQQESFLLLCFHGDGRAENMVQWEMEVCKLPRLSLNGVRFKRISGSSIAFKNIASKV 729
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000042362.1 (SMESG000042362.1)

HSP 1 Score: 2166.73 bits (5613), Expect = 0.000e+0
Identity = 1173/1183 (99.15%), Postives = 1174/1183 (99.24%), Query Frame = 1 
Query:  103 MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINPSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNXXXXXXXXXXXXXXXXXXXXXXXXERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFXXXXXXXXXXXVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPXXXXXXXXXXXXXPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEM---EVSEKESDELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKXXXXXXXXXXXXXXXIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQXXXXXXXXXXXXXXXXXXXLTTKISKKQASQVDDVDIRPTLWMRHATTHEKLXXXXXXXXXXXXXQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLIXXXXXXXXXXXXXXIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE 3642
            MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSIN SKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNGTSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSNGPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEM   E   + S ELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSLTTKISKKQASQVDDVDIRPTLWMRHATTHEKLSNPSPSINRSPSNQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE
Sbjct:    1 MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINSSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNGTSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSNGPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEMEVSEKESEISSELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSLTTKISKKQASQVDDVDIRPTLWMRHATTHEKLSNPSPSINRSPSNQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE 1183
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000042362.1 (SMESG000042362.1)

HSP 1 Score: 2137.07 bits (5536), Expect = 0.000e+0
Identity = 1162/1183 (98.22%), Postives = 1163/1183 (98.31%), Query Frame = 1 
Query:  103 MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINPSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNXXXXXXXXXXXXXXXXXXXXXXXXERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFXXXXXXXXXXXVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPXXXXXXXXXXXXXPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEM---EVSEKESDELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKXXXXXXXXXXXXXXXIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQXXXXXXXXXXXXXXXXXXXLTTKISKKQASQVDDVDIRPTLWMRHATTHEKLXXXXXXXXXXXXXQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLIXXXXXXXXXXXXXXIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE 3642
            MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSIN SKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNGTSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSNGPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEM   E   + S ELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSLTTKISKK           PTLWMRHATTHEKLSNPSPSINRSPSNQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE
Sbjct:    1 MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSPSINSSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNGTSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPSTKPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDISRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSNGPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVDSESCDSNIGEMEVSEKESEISSELKINEDSAISREDDRCSGSETSSSNKLIETNIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQSNFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPKEQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDSKHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGNREQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIALGGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSLTTKISKK-----------PTLWMRHATTHEKLSNPSPSINRSPSNQDSASMGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNKATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRIIE 1172
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 490.73 bits (1262), Expect = 4.192e-155
Identity = 221/343 (64.43%), Postives = 278/343 (81.05%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWE---NGMPKPSTKPNQNTIVPNYLNNRPQ 1503
            P  GKYKLI+ IGKGNFAKVKLAQH+ TGK+VAVK+IDKT LN  +LQKL REV+IMK ++HPNIV+L+EVI++ER +YLVME A  GEVF+YLV+NGRMKEKDAR +FR+IVSA+QYCH K IVHRDLKAENLLL  DL IKIADFGF+N+F  + +L+TFCGSPPYAAPELFQGR+YEGPEVDVWSLGVILYTL+SGSLPFDG  +RELRERVLRGKYRIPFYM++DCE LL+KML++NP +R  L D+MKD WIN G+E+  L+P+ EP+ +Y D  ++ ++ S+GFT  ++ +SL   +++++TA YLL +   N   + S+K +    + N  NN  Q
Sbjct:   16 PHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQ 358

HSP 2 Score: 62.7734 bits (151), Expect = 1.795e-9
Identity = 39/104 (37.50%), Postives = 56/104 (53.85%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLV-AFHIDY---EQRSSFVLMC---IYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRII 3639
            Q KPR     FR  +TSK  P+ +++E+ + L  +  ID+   EQ  +FV+ C   +  E  G  +IHWE+EV RL   S  GIR K+  G   + K I K +I
Sbjct:  717 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILI 820
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 491.115 bits (1263), Expect = 4.267e-155
Identity = 221/343 (64.43%), Postives = 278/343 (81.05%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWE---NGMPKPSTKPNQNTIVPNYLNNRPQ 1503
            P  GKYKLI+ IGKGNFAKVKLAQH+ TGK+VAVK+IDKT LN  +LQKL REV+IMK ++HPNIV+L+EVI++ER +YLVME A  GEVF+YLV+NGRMKEKDAR +FR+IVSA+QYCH K IVHRDLKAENLLL  DL IKIADFGF+N+F  + +L+TFCGSPPYAAPELFQGR+YEGPEVDVWSLGVILYTL+SGSLPFDG  +RELRERVLRGKYRIPFYM++DCE LL+KML++NP +R  L D+MKD WIN G+E+  L+P+ EP+ +Y D  ++ ++ S+GFT  ++ +SL   +++++TA YLL +   N   + S+K +    + N  NN  Q
Sbjct:   28 PHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQ 370

HSP 2 Score: 62.7734 bits (151), Expect = 1.687e-9
Identity = 39/104 (37.50%), Postives = 56/104 (53.85%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLV-AFHIDY---EQRSSFVLMC---IYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRII 3639
            Q KPR     FR  +TSK  P+ +++E+ + L  +  ID+   EQ  +FV+ C   +  E  G  +IHWE+EV RL   S  GIR K+  G   + K I K +I
Sbjct:  729 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILI 832
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 491.115 bits (1263), Expect = 7.358e-155
Identity = 221/343 (64.43%), Postives = 278/343 (81.05%), Query Frame = 1 
Query:  484 PTFGKYKLIREIGKGNFAKVKLAQHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQTERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKMIVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPELFQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIPFYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPEIDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWE---NGMPKPSTKPNQNTIVPNYLNNRPQ 1503
            P  GKYKLI+ IGKGNFAKVKLAQH+ TGK+VAVK+IDKT LN  +LQKL REV+IMK ++HPNIV+L+EVI++ER +YLVME A  GEVF+YLV+NGRMKEKDAR +FR+IVSA+QYCH K IVHRDLKAENLLL  DL IKIADFGF+N+F  + +L+TFCGSPPYAAPELFQGR+YEGPEVDVWSLGVILYTL+SGSLPFDG  +RELRERVLRGKYRIPFYM++DCE LL+KML++NP +R  L D+MKD WIN G+E+  L+P+ EP+ +Y D  ++ ++ S+GFT  ++ +SL   +++++TA YLL +   N   + S+K +    + N  NN  Q
Sbjct:   16 PHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQ 358

HSP 2 Score: 63.1586 bits (152), Expect = 1.591e-9
Identity = 39/104 (37.50%), Postives = 56/104 (53.85%), Query Frame = 1 
Query: 3349 QTKPRNFRFSFRTEVTSKKSPDELMAEIKRVLV-AFHIDY---EQRSSFVLMC---IYGENTGEAVIHWEMEVVRLNSKSLNGIRFKRLFGPQIKCKEISKRII 3639
            Q KPR     FR  +TSK  P+ +++E+ + L  +  ID+   EQ  +FV+ C   +  E  G  +IHWE+EV RL   S  GIR K+  G   + K I K +I
Sbjct:  748 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILI 851
The following BLAST results are available for this feature:
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MARK31.447e-16061.48microtubule affinity regulating kinase 3 [Source:H... [more]
MARK37.184e-15971.57microtubule affinity regulating kinase 3 [Source:H... [more]
MARK31.411e-15871.57microtubule affinity regulating kinase 3 [Source:H... [more]
MARK32.755e-15871.57microtubule affinity regulating kinase 3 [Source:H... [more]
MARK43.474e-15770.61microtubule affinity regulating kinase 4 [Source:H... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
par-18.918e-14869.97Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-18.918e-14869.97Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-18.918e-14869.97Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-18.918e-14869.97Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-18.918e-14869.97Serine/threonine-protein kinase par-1 [Source:Uni... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
par-18.808e-15872.03gene:FBgn0260934 transcript:FBtr0301505[more]
par-11.039e-15772.03gene:FBgn0260934 transcript:FBtr0330243[more]
par-12.020e-15772.03gene:FBgn0260934 transcript:FBtr0100390[more]
par-14.312e-15572.03gene:FBgn0260934 transcript:FBtr0086450[more]
par-14.256e-15472.03gene:FBgn0260934 transcript:FBtr0086457[more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mark3a2.765e-15971.57MAP/microtubule affinity-regulating kinase 3a [Sou... [more]
mark3b5.704e-15871.88MAP/microtubule affinity-regulating kinase 3b [Sou... [more]
mark3a1.119e-15771.57MAP/microtubule affinity-regulating kinase 3a [Sou... [more]
mark3a1.938e-15771.57MAP/microtubule affinity-regulating kinase 3a [Sou... [more]
mark3a2.282e-15771.57MAP/microtubule affinity-regulating kinase 3a [Sou... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MARK31.473e-15972.20microtubule affinity regulating kinase 3 [Source:N... [more]
MARK32.170e-15972.20microtubule affinity regulating kinase 3 [Source:N... [more]
MARK33.211e-15972.20microtubule affinity regulating kinase 3 [Source:N... [more]
MARK33.903e-15972.20microtubule affinity regulating kinase 3 [Source:N... [more]
mark21.771e-15570.29microtubule affinity regulating kinase 2 [Source:N... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mark37.492e-16072.20MAP/microtubule affinity regulating kinase 3 [Sour... [more]
Mark38.821e-16072.20MAP/microtubule affinity regulating kinase 3 [Sour... [more]
Mark31.934e-15972.20MAP/microtubule affinity regulating kinase 3 [Sour... [more]
Mark36.002e-15972.20MAP/microtubule affinity regulating kinase 3 [Sour... [more]
Mark46.935e-15770.29MAP/microtubule affinity regulating kinase 4 [Sour... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q03141|MARK3_MOUSE1.353e-15872.20MAP/microtubule affinity-regulating kinase 3 OS=Mu... [more]
sp|Q8VHF0|MARK3_RAT1.298e-15771.88MAP/microtubule affinity-regulating kinase 3 OS=Ra... [more]
sp|P27448|MARK3_HUMAN1.323e-15771.57MAP/microtubule affinity-regulating kinase 3 OS=Ho... [more]
sp|O08679|MARK2_RAT9.525e-15570.93Serine/threonine-protein kinase MARK2 OS=Rattus no... [more]
sp|Q96L34|MARK4_HUMAN1.097e-15470.61MAP/microtubule affinity-regulating kinase 4 OS=Ho... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A172RVS00.000e+097.30Non-specific serine/threonine protein kinase (Frag... [more]
A0A0D9RCG93.786e-15972.20Microtubule affinity regulating kinase 3 OS=Chloro... [more]
A0A3B5LCQ54.823e-15967.63Microtubule affinity regulating kinase 3 OS=Xiphop... [more]
H9YXQ11.349e-15861.99Non-specific serine/threonine protein kinase OS=Ma... [more]
A0A1U7T1S41.364e-15862.47Non-specific serine/threonine protein kinase OS=Ta... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mark3b3.718e-15972.20MAP/microtubule affinity-regulating kinase 3 [Sour... [more]
mark3b4.413e-15972.20MAP/microtubule affinity-regulating kinase 3 [Sour... [more]
mark3a4.662e-15970.98microtubule affinity regulating kinase 3 [Source:N... [more]
mark3b4.735e-15972.20MAP/microtubule affinity-regulating kinase 3 [Sour... [more]
mark3a1.451e-15870.98microtubule affinity regulating kinase 3 [Source:N... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000006410.11.304e-16070.85pep scaffold:Pmarinus_7.0:GL476370:17405:31068:-1 ... [more]
MARK31.176e-15770.97microtubule affinity regulating kinase 3 [Source:H... [more]
MARK31.261e-15471.38microtubule affinity regulating kinase 3 [Source:H... [more]
snrka1.875e-7341.05SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040... [more]
NIM1K1.459e-6741.91NIM1 serine/threonine protein kinase [Source:HGNC ... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
SNF16.094e-7841.30AMP-activated S/T protein kinase; forms a complex ... [more]
KCC44.522e-6144.70Protein kinase of the bud neck involved in the sep... [more]
GIN45.601e-6144.65Protein kinase involved in bud growth and assembly... [more]
HSL15.966e-5837.75Nim1p-related protein kinase; septin-binding kinas... [more]
KIN22.806e-5635.76Serine/threonine protein kinase involved in regula... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO307683.583e-15470.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO460351.196e-11153.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319321.169e-9848.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361696.414e-7642.72Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO365879.578e-7341.38Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mark3a2.486e-16072.20microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a4.236e-16072.20microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.054e-15872.20microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.280e-15872.20microtubule affinity regulating kinase 3 [Source:N... [more]
mark3a1.656e-15872.20microtubule affinity regulating kinase 3 [Source:N... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000042362.10.000e+099.15SMESG000042362.1[more]
SMESG000042362.10.000e+098.22SMESG000042362.1[more]
SMESG000057003.14.192e-15564.43SMESG000057003.1[more]
SMESG000057003.14.267e-15564.43SMESG000057003.1[more]
SMESG000057003.17.358e-15564.43SMESG000057003.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003323 ID=SMED30003323|Name=Non-specific serine/threonine protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=4221bp
ATCTATATAAATCTTATATGGAATGTTATAGATTGATATTTTTATGAAAA
TAAAAATTCATTATATTTTGGTATTTATTATTGGATATTTCTATTCATTA
CAATGAATACAACAGTTGCGCCATATGCTGTCAAAGAAGATAACAAAAAA
TTTGATATTACTCGGAATAAAATATACATGCAACAGAAACCTAATATTAT
CAATAGCAAAATCACTTATCGTCCATCACACGTTCCTAATAATTATTCGC
CATCTATTAATCCATCTAAACCTCGAAATCAGTATAATCCTCAAGTACCC
ACAAGCAACAATCAACCAAGTCGTATTTATAATGGACAACAAATTCAGCA
GCCTCATTTTAACACACAACCAATAAATGGACCTCGATCGTATCCAAACG
GAACGTCAGCTGGCAGTACCAGAAGTTCAGTGTCAAGTCGCGGAGCTTCA
GGAAACAACAGTTCGATGTCAGAACGAAACGGACCGACATTTGGAAAATA
TAAATTAATTAGAGAAATCGGTAAAGGAAATTTCGCAAAAGTTAAATTAG
CACAGCATTTAATAACGGGAAAAGAGGTCGCAGTGAAAATTATTGATAAA
ACCAAACTCAATGCTCCGGCTTTACAAAAGCTAACTAGAGAAGTTAAAAT
AATGAAAGAGCTTAATCATCCTAATATTGTTCGCTTATATGAAGTTATTC
AAACTGAACGATCTTTATATTTGGTTATGGAAAATGCTCAAAATGGTGAA
GTTTTTGAGTATCTTGTAAAGAATGGTCGAATGAAAGAGAAAGATGCACG
AGCAAAATTCCGTCAAATTGTTTCTGCTGTTCAATACTGTCATCAAAAAA
TGATTGTTCACAGAGATCTTAAAGCGGAAAATCTTTTATTGGATAAAGAT
CTTAGTATTAAAATAGCGGATTTCGGTTTCTCCAATCATTTTTCACGTCA
ATCAAAGTTGAATACATTCTGTGGTAGTCCACCTTATGCTGCCCCAGAGC
TTTTCCAAGGCAGGAGGTATGAAGGTCCAGAGGTTGATGTTTGGTCGTTA
GGTGTAATTCTTTATACACTAATCAGTGGGTCACTTCCGTTTGATGGTGG
AACTTTGAGAGAATTGAGAGAAAGAGTATTAAGAGGTAAATACCGAATCC
CATTTTACATGTCATCGGACTGTGAAGCATTACTAAGAAAAATGCTTGTA
CTGAATCCACAAAGAAGATTACCATTGACAGACATCATGAAAGATACTTG
GATTAATGTCGGATATGAAGAATGCCCCCTAAGACCGTTTTATGAGCCAG
AAATTGATTATAATGATCAATCAAAAATAGACGTCCTACTTAGTATGGGT
TTTACTCTCCAACAAATAACCGAGTCATTGCAACAGAAAAGATATGACAG
TATCACTGCAATATATTTATTGTGGGAAAACGGGATGCCCAAACCCTCAA
CGAAACCCAACCAAAATACAATTGTTCCAAATTATTTGAATAATAGACCG
CAACCTAATTTCTCACAAATTACGTCGACCTCGACATCACAATCAGTGGC
AATTCCAGAAATGCCCGCCCTAGCCAAAACTCAATATACGACCCAAGATA
TTTCCAGAAATGCTATATCACACAACCGATCTCAGAGCTCGAGATTCTAT
CGTAAACCCACATCACACACAACTACGACATCTATTGACAACGATCCTTC
CATTGAAAAACAACCTTCATCAAGTTGTAGTAGTACTGGATCGGGCTCTA
ATGGACCAGCAACATATGATTTCACTCAATCCAAATCTCAGAAACACAAA
GAAACCGAAGAGAAAAGACCAAGACCCCAAACTCATAGAACCGCTGTGTC
TCCTTATTCAGATGTTACAATAAAAGAAACATCTAACGAAACAAAAGTAG
ACAGTGAAAGCTGTGATTCAAACATTGGTGAAATGGAAGTCAGCGAAAAG
GAATCAGATGAACTTAAAATCAACGAAGACTCGGCGATTAGCAGGGAAGA
TGACCGGTGTTCTGGATCTGAAACGTCTTCGTCGAATAAGCTCATTGAAA
CGAACATTGATGATCTGGATATATCTAGAATACATCAGCACAGTTCTGAA
AAACCCAATATAAAAGTCAAACGCACACAAACTTTCAATAACTACCCAAT
GTCCCACAATCCTATCAATAGTCCAGTAAGAAAAACCTTTGCAGAGCAAA
GTAATTTCAATTACGGCCTATTCTCCCATCAGTCCAATGATCAGGCTAAA
CTCAACCAAGGCTTCAATAACTCTCCGCTCAATATTGTGGCCAATAAAAA
TACTACACTCAATATCAATTCTGGAAGTTATGAATCAGAAAACCCCCCAA
AAGAACAGTATGGTGTCAAACTTCAGAGATCCAATACATCAAACGTAAGA
TCTGTAACTAACACTTTCAAACAAATGGTAATTTCCGAACCGATGGATAA
ATTAATTGAGGAGCCTGATAACTCCAACGACAACGAAGCTTCTCGTGATT
CAAAGCATTTTCAACGTGCCACAAAAGGTTATCAGTCTCTGAGACTTCCA
GATATGGTGCCGCCATATCAAGCATTTGCTGGTTCGCCATGTTACAATAG
TGCTTTTCCCAAGAAAGATGATTCTAATCAACAAACAGGAGTTGCTGGAA
ATCGAGAACAGTCGCCGTTTTCTCGGAACACTCCTGAACGAGCAACAATT
CAGCATGTTCCACAAAACAAACGAGAACGAATCCAATTGGAAACAAAAGT
GCTGAGCGGCGTAGGAGGTCCCAGTGGTCCAAGTAACTTGCCAATAGCTT
TGGGTGGTTCAATTAGTCACCCACAACCCCCTAAAAAAGAGAAGATCAAC
TGTCACTCAAAAAAACCTTCCGATGATAACCTGAATGATCAAATCAACAT
TTCCAACAACAAACCGAAAAAGAAATCAGTCAATTCTTTCTTTAAGTCTT
TGACAACAAAAATATCAAAAAAGCAGGCATCACAAGTAGATGACGTTGAT
ATCAGACCGACTTTATGGATGAGGCACGCAACTACTCATGAAAAGTTATC
CAATCCATCTCCTAGTATTAATCGATCCCCGTCAAATCAGGATTCTGCGT
CAATGGGTCAAGGTACGATGCAGAGGTCAAATGTTAATCAAAATCGGTAT
ATTGACACGAAAGAAAAGTGGTCAAATTTTACTGCTGAAGCTTCACCATC
TCCATCTCCATATTTTCCTGACAGGTCTGGAAGATATGGCCAATCTAATA
AAGCCACTAATTTTGACATGGAAAATCTCATAACAAGCAGCTGTGCAACG
AGTCTGACGAGTAGTGGTTCGTCCATTGCAAATCCTACTAATAAAGTGCA
AACCAAACCGAGAAATTTTCGATTTTCTTTCAGAACTGAAGTGACTAGTA
AAAAAAGTCCCGATGAATTAATGGCAGAAATAAAAAGAGTATTGGTGGCA
TTCCATATAGATTATGAACAACGTTCAAGTTTTGTGCTGATGTGTATCTA
TGGTGAGAACACTGGTGAAGCGGTTATTCATTGGGAAATGGAGGTGGTCA
GGCTCAATTCCAAATCATTGAATGGAATACGCTTCAAAAGACTATTTGGG
CCACAAATCAAGTGCAAGGAAATTTCAAAACGAATAATTGAAAGATTACA
GTTGTGATTTACCAGATAGTCACGTTTGCGTTCTTCTATAAACTTCGTCA
AATTGTTCTCGCCTTACTAAGACTCTTTCCGTTTGTTTATAACACATCCA
ATGATTTTTTTTGTGTTTCTCACTCATGTTGATTTCAGCTTCTATTCAAT
GTACAGAGTTTATCCCCCCTAATTAGAAATCAACATGAAAGCTATTGCAT
ACATTTTGCAAATCGCACCCGAGCGTTGTCGATTTTTAATATGTGAAACC
CACAATGATATATCTATGATCCAAATTGCATCGACATTGTTGATCCTGAT
CTATATTCAATAAGAACATATTCCAGTTGATCGAATCATATTGTATACCT
TACTCTTTGACAGCTCTAATGATCTTGTGTAGTTTTTGTATATGAATTAT
ATCACATCATGCTTTCACATTTTAACATGTATAACTATTGGGAACAATTA
TACGATTTCGTTTTTGATGCAATTTTATATCCACATTGTAATGGAAATGA
GAAAAATTTATTTTTTCAAAATATCTCTTCAACACTTTCAATATCTCGTA
ATCGCTATTCTATTTCCAGTT
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protein sequence of SMED30003323-orf-1

>SMED30003323-orf-1 ID=SMED30003323-orf-1|Name=SMED30003323-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1185bp
MNTTVAPYAVKEDNKKFDITRNKIYMQQKPNIINSKITYRPSHVPNNYSP
SINPSKPRNQYNPQVPTSNNQPSRIYNGQQIQQPHFNTQPINGPRSYPNG
TSAGSTRSSVSSRGASGNNSSMSERNGPTFGKYKLIREIGKGNFAKVKLA
QHLITGKEVAVKIIDKTKLNAPALQKLTREVKIMKELNHPNIVRLYEVIQ
TERSLYLVMENAQNGEVFEYLVKNGRMKEKDARAKFRQIVSAVQYCHQKM
IVHRDLKAENLLLDKDLSIKIADFGFSNHFSRQSKLNTFCGSPPYAAPEL
FQGRRYEGPEVDVWSLGVILYTLISGSLPFDGGTLRELRERVLRGKYRIP
FYMSSDCEALLRKMLVLNPQRRLPLTDIMKDTWINVGYEECPLRPFYEPE
IDYNDQSKIDVLLSMGFTLQQITESLQQKRYDSITAIYLLWENGMPKPST
KPNQNTIVPNYLNNRPQPNFSQITSTSTSQSVAIPEMPALAKTQYTTQDI
SRNAISHNRSQSSRFYRKPTSHTTTTSIDNDPSIEKQPSSSCSSTGSGSN
GPATYDFTQSKSQKHKETEEKRPRPQTHRTAVSPYSDVTIKETSNETKVD
SESCDSNIGEMEVSEKESDELKINEDSAISREDDRCSGSETSSSNKLIET
NIDDLDISRIHQHSSEKPNIKVKRTQTFNNYPMSHNPINSPVRKTFAEQS
NFNYGLFSHQSNDQAKLNQGFNNSPLNIVANKNTTLNINSGSYESENPPK
EQYGVKLQRSNTSNVRSVTNTFKQMVISEPMDKLIEEPDNSNDNEASRDS
KHFQRATKGYQSLRLPDMVPPYQAFAGSPCYNSAFPKKDDSNQQTGVAGN
REQSPFSRNTPERATIQHVPQNKRERIQLETKVLSGVGGPSGPSNLPIAL
GGSISHPQPPKKEKINCHSKKPSDDNLNDQINISNNKPKKKSVNSFFKSL
TTKISKKQASQVDDVDIRPTLWMRHATTHEKLSNPSPSINRSPSNQDSAS
MGQGTMQRSNVNQNRYIDTKEKWSNFTAEASPSPSPYFPDRSGRYGQSNK
ATNFDMENLITSSCATSLTSSGSSIANPTNKVQTKPRNFRFSFRTEVTSK
KSPDELMAEIKRVLVAFHIDYEQRSSFVLMCIYGENTGEAVIHWEMEVVR
LNSKSLNGIRFKRLFGPQIKCKEISKRIIERLQL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016740transferase activity
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
IPR015940UBA
IPR000719Prot_kinase_dom
IPR028375KA1/Ssp2_C
IPR001772KA1_dom
IPR008271Ser/Thr_kinase_AS
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0000226microtubule cytoskeleton organization
GO:0016310phosphorylation
GO:0030010establishment of cell polarity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR015940Ubiquitin-associated domainSMARTSM00165uba_6coord: 405..442
e-value: 1.5E-4
score: 31.1
IPR015940Ubiquitin-associated domainPROSITEPS50030UBAcoord: 403..443
score: 10.499
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 133..384
e-value: 3.8E-104
score: 362.0
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 133..384
e-value: 1.6E-73
score: 247.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 133..384
score: 52.414
IPR001772Kinase associated domain 1 (KA1)PFAMPF02149KA1coord: 1140..1184
e-value: 3.6E-11
score: 42.7
IPR001772Kinase associated domain 1 (KA1)PROSITEPS50032KA1coord: 1135..1184
score: 14.254
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 212..398
e-value: 8.3E-63
score: 213.2
NoneNo IPR availableGENE3DG3DSA:1.10.8.10coord: 399..443
e-value: 8.3E-16
score: 59.3
NoneNo IPR availableGENE3DG3DSA:3.30.310.80coord: 1076..1184
e-value: 7.7E-29
score: 102.0
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 118..210
e-value: 5.6E-34
score: 118.2
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 838..872
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 838..867
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 88..126
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 978..1008
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 560..577
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 36..68
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 593..639
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 495..559
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 495..643
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 904..924
NoneNo IPR availablePANTHERPTHR24346:SF28MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4coord: 942..1145
coord: 105..618
NoneNo IPR availablePANTHERPTHR24346MAP/MICROTUBULE AFFINITY-REGULATING KINASEcoord: 942..1145
coord: 105..618
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 139..162
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 251..263
IPR028375KA1 domain/Ssp2, C-terminalSUPERFAMILYSSF103243KA1-likecoord: 1079..1184
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 130..461