Tyrosine-protein kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30003251 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11Note: Hover over icons to view figure legend
Homology
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283]) HSP 1 Score: 166.777 bits (421), Expect = 4.601e-68 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 HSP 2 Score: 77.7962 bits (190), Expect = 4.601e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 202 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGK 359 HSP 3 Score: 57.7658 bits (138), Expect = 4.601e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283]) HSP 1 Score: 166.777 bits (421), Expect = 4.601e-68 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 HSP 2 Score: 77.7962 bits (190), Expect = 4.601e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 202 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGK 359 HSP 3 Score: 57.7658 bits (138), Expect = 4.601e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283]) HSP 1 Score: 166.777 bits (421), Expect = 4.601e-68 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 HSP 2 Score: 77.7962 bits (190), Expect = 4.601e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 202 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGK 359 HSP 3 Score: 57.7658 bits (138), Expect = 4.601e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283]) HSP 1 Score: 167.162 bits (422), Expect = 5.887e-67 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 365 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 526 HSP 2 Score: 77.7962 bits (190), Expect = 5.887e-67 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 208 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGK 365 HSP 3 Score: 53.9138 bits (128), Expect = 5.887e-67 Identity = 34/114 (29.82%), Postives = 58/114 (50.88%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVL------EVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ +V + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 204
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: LYN (LYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735]) HSP 1 Score: 168.318 bits (425), Expect = 1.709e-66 Identity = 86/183 (46.99%), Postives = 112/183 (61.20%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
K L ++I A+I+EGMAY+E + +HRDLRA N+LV++ L K+ADFGL + E NE ++ +FP KWTAPEA FT KSDVWSFGI++YEI+T+ PYP +V+ +S GYRMP E +CPDE+Y IM CW +RPTF LQ LD A+ G Y Q
Sbjct: 317 KVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIED-NEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE------NCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY--TATEGQYQQQ 490 HSP 2 Score: 67.3958 bits (163), Expect = 1.709e-66 Identity = 57/165 (34.55%), Postives = 87/165 (52.73%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVR-GFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
++KH++I+ N Y I+ R FP I +I+ Y+K G + Q P EI RE+I+++ +G G FG V + + +VA K L+ + FL+EA +M L+H K+V L V T ++ P+ II E+M GSL ++LKSDEG K
Sbjct: 158 VIKHYKIR---SLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLKSDEGGK 317 HSP 3 Score: 61.2326 bits (147), Expect = 1.709e-66 Identity = 40/108 (37.04%), Postives = 58/108 (53.70%), Query Frame = 1
Query: 3427 MVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRK-ENCFALSVRDFD 3747
+V A Y Y D+SF+ E M VLE E W L K +G +P+NYV+K + +++I R +AE+ L+ G G ++IR S + F+LSVRDFD
Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKK-EGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFD 152
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 155.606 bits (392), Expect = 4.842e-63 Identity = 78/180 (43.33%), Postives = 107/180 (59.44%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLT----VKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIY-KIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
+ ++ M A+I+ GM YLE K+VHRDL A N+LV D ++ VKVADFGL + + + +FP KWTAPEAA FT KSDVWS+GI++YEI+T PYP +EV+++V GYRMP P CP++IY ++++ CW P +RPTF +L D V N
Sbjct: 358 GIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG------CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPN 531 HSP 2 Score: 66.2402 bits (160), Expect = 4.842e-63 Identity = 57/170 (33.53%), Postives = 85/170 (50.00%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVP------LTDPLP--DNYQPPIHF---QDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSD 4246
VKH++IK ++ + R F + L+++Y S VP LT P P +P + Q+ EI R + + ++G G FG V KW EVA K ++ E FLQEA+IM + H +V+L VCT ++ P II E+M GSL +YL++D
Sbjct: 194 VKHYKIK-RLDHDQGYFITTRRTFRSLQELVRYY-------SDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCT--REEPFYIITEYMINGSLLQYLRTD 353 HSP 3 Score: 62.3882 bits (150), Expect = 4.842e-63 Identity = 38/112 (33.93%), Postives = 66/112 (58.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA--WR--EIQRWEAEKLLMRVGLQKGTYIIRPSRKENC-FALSVRDFDEKK 3756
A Y Y + A+ D+SF+ + M++L+ + W V + + G VP N+V+KQ Q++E+ W +I R AE+L++ L KGT++IR + FAL++RD D+++
Sbjct: 82 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQ----QTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQR 189
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 155.606 bits (392), Expect = 4.842e-63 Identity = 78/180 (43.33%), Postives = 107/180 (59.44%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLT----VKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIY-KIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
+ ++ M A+I+ GM YLE K+VHRDL A N+LV D ++ VKVADFGL + + + +FP KWTAPEAA FT KSDVWS+GI++YEI+T PYP +EV+++V GYRMP P CP++IY ++++ CW P +RPTF +L D V N
Sbjct: 358 GIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG------CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPN 531 HSP 2 Score: 66.2402 bits (160), Expect = 4.842e-63 Identity = 57/170 (33.53%), Postives = 85/170 (50.00%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVP------LTDPLP--DNYQPPIHF---QDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSD 4246
VKH++IK ++ + R F + L+++Y S VP LT P P +P + Q+ EI R + + ++G G FG V KW EVA K ++ E FLQEA+IM + H +V+L VCT ++ P II E+M GSL +YL++D
Sbjct: 194 VKHYKIK-RLDHDQGYFITTRRTFRSLQELVRYY-------SDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCT--REEPFYIITEYMINGSLLQYLRTD 353 HSP 3 Score: 62.3882 bits (150), Expect = 4.842e-63 Identity = 38/112 (33.93%), Postives = 66/112 (58.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA--WR--EIQRWEAEKLLMRVGLQKGTYIIRPSRKENC-FALSVRDFDEKK 3756
A Y Y + A+ D+SF+ + M++L+ + W V + + G VP N+V+KQ Q++E+ W +I R AE+L++ L KGT++IR + FAL++RD D+++
Sbjct: 82 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQ----QTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQR 189
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 155.606 bits (392), Expect = 5.758e-63 Identity = 78/180 (43.33%), Postives = 107/180 (59.44%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLT----VKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIY-KIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
+ ++ M A+I+ GM YLE K+VHRDL A N+LV D ++ VKVADFGL + + + +FP KWTAPEAA FT KSDVWS+GI++YEI+T PYP +EV+++V GYRMP P CP++IY ++++ CW P +RPTF +L D V N
Sbjct: 354 GIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG------CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPN 527 HSP 2 Score: 66.2402 bits (160), Expect = 5.758e-63 Identity = 57/170 (33.53%), Postives = 85/170 (50.00%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVP------LTDPLP--DNYQPPIHF---QDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSD 4246
VKH++IK ++ + R F + L+++Y S VP LT P P +P + Q+ EI R + + ++G G FG V KW EVA K ++ E FLQEA+IM + H +V+L VCT ++ P II E+M GSL +YL++D
Sbjct: 190 VKHYKIK-RLDHDQGYFITTRRTFRSLQELVRYY-------SDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCT--REEPFYIITEYMINGSLLQYLRTD 349 HSP 3 Score: 62.3882 bits (150), Expect = 5.758e-63 Identity = 38/112 (33.93%), Postives = 66/112 (58.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA--WR--EIQRWEAEKLLMRVGLQKGTYIIRPSRKENC-FALSVRDFDEKK 3756
A Y Y + A+ D+SF+ + M++L+ + W V + + G VP N+V+KQ Q++E+ W +I R AE+L++ L KGT++IR + FAL++RD D+++
Sbjct: 78 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQ----QTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQR 185
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 155.606 bits (392), Expect = 5.758e-63 Identity = 78/180 (43.33%), Postives = 107/180 (59.44%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLT----VKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIY-KIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
+ ++ M A+I+ GM YLE K+VHRDL A N+LV D ++ VKVADFGL + + + +FP KWTAPEAA FT KSDVWS+GI++YEI+T PYP +EV+++V GYRMP P CP++IY ++++ CW P +RPTF +L D V N
Sbjct: 354 GIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG------CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPN 527 HSP 2 Score: 66.2402 bits (160), Expect = 5.758e-63 Identity = 57/170 (33.53%), Postives = 85/170 (50.00%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVP------LTDPLP--DNYQPPIHF---QDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSD 4246
VKH++IK ++ + R F + L+++Y S VP LT P P +P + Q+ EI R + + ++G G FG V KW EVA K ++ E FLQEA+IM + H +V+L VCT ++ P II E+M GSL +YL++D
Sbjct: 190 VKHYKIK-RLDHDQGYFITTRRTFRSLQELVRYY-------SDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCT--REEPFYIITEYMINGSLLQYLRTD 349 HSP 3 Score: 62.3882 bits (150), Expect = 5.758e-63 Identity = 38/112 (33.93%), Postives = 66/112 (58.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA--WR--EIQRWEAEKLLMRVGLQKGTYIIRPSRKENC-FALSVRDFDEKK 3756
A Y Y + A+ D+SF+ + M++L+ + W V + + G VP N+V+KQ Q++E+ W +I R AE+L++ L KGT++IR + FAL++RD D+++
Sbjct: 78 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQ----QTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQR 185
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 155.221 bits (391), Expect = 7.147e-63 Identity = 78/180 (43.33%), Postives = 107/180 (59.44%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLT----VKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIY-KIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
+ ++ M A+I+ GM YLE K+VHRDL A N+LV D ++ VKVADFGL + + + +FP KWTAPEAA FT KSDVWS+GI++YEI+T PYP +EV+++V GYRMP P CP++IY ++++ CW P +RPTF +L D V N
Sbjct: 298 GIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG------CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPN 471 HSP 2 Score: 66.2402 bits (160), Expect = 7.147e-63 Identity = 55/164 (33.54%), Postives = 83/164 (50.61%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP--DNYQPPIHF---QDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSD 4246
VKH++IK ++ + R F + L+++Y G LT P P +P + Q+ EI R + + ++G G FG V KW EVA K ++ E FLQEA+IM + H +V+L VCT ++ P II E+M GSL +YL++D
Sbjct: 134 VKHYKIK-RLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLC-CQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCT--REEPFYIITEYMINGSLLQYLRTD 293 HSP 3 Score: 62.003 bits (149), Expect = 7.147e-63 Identity = 40/123 (32.52%), Postives = 69/123 (56.10%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA--WR--EIQRWEAEKLLMRVGLQKGTYIIRPSRKENC-FALSVRDFDEKKKNFLGKAFSNK 3789
A Y Y + A+ D+SF+ + M++L+ + W V + + G VP N+V+KQ Q++E+ W +I R AE+L++ L KGT++IR + FAL++RD D+++ K + K
Sbjct: 22 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQ----QTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIK 140
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src42A (gene:FBgn0264959 transcript:FBtr0335276) HSP 1 Score: 171.4 bits (433), Expect = 1.298e-57 Identity = 81/180 (45.00%), Postives = 114/180 (63.33%), Query Frame = 3
Query: 4248 KEKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
K + + +I M A+I+ GMAYLES+ +HRDL A N+LV D VK+ADFGL + + +E + + RFP KWTAPEAA F+ KSDVWSFGI++ E++T+ PYP EV+ +V GYRMP P +C +Y+IM++CWH DP +RPTF +LQ +L+ + S+
Sbjct: 1418 KGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK-EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPP------NCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSD 1590 HSP 2 Score: 73.9442 bits (180), Expect = 1.298e-57 Identity = 40/86 (46.51%), Postives = 52/86 (60.47%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
G G FG V + W VA K L+S + + FL EA+IM KLRH K+++L VCT + P+ II E MK GSL EYL++ GK
Sbjct: 1335 GSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCT--VEEPIYIITELMKHGSLLEYLQAIAGK 1418
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src42A (gene:FBgn0264959 transcript:FBtr0335275) HSP 1 Score: 170.629 bits (431), Expect = 2.398e-57 Identity = 81/180 (45.00%), Postives = 114/180 (63.33%), Query Frame = 3
Query: 4248 KEKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
K + + +I M A+I+ GMAYLES+ +HRDL A N+LV D VK+ADFGL + + +E + + RFP KWTAPEAA F+ KSDVWSFGI++ E++T+ PYP EV+ +V GYRMP P +C +Y+IM++CWH DP +RPTF +LQ +L+ + S+
Sbjct: 338 KGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK-EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPP------NCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSD 510 HSP 2 Score: 73.9442 bits (180), Expect = 2.398e-57 Identity = 40/86 (46.51%), Postives = 52/86 (60.47%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
G G FG V + W VA K L+S + + FL EA+IM KLRH K+++L VCT + P+ II E MK GSL EYL++ GK
Sbjct: 255 GSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE--PIYIITELMKHGSLLEYLQAIAGK 338 HSP 3 Score: 59.3066 bits (142), Expect = 2.215e-8 Identity = 40/112 (35.71%), Postives = 62/112 (55.36%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA----WREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y A + D+SF E + +L W K ++ +G +P+NYV+K +S+EA +R+I+R EAEK L+ + G ++IR S + N ++LSVRD D K
Sbjct: 70 ALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNYVAKL----KSIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVK 177
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100508) HSP 1 Score: 149.058 bits (375), Expect = 2.788e-55 Identity = 67/170 (39.41%), Postives = 105/170 (61.76%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIV 4772
+ +I++ +++ GM YLES++++HRDL A N+L+ ++ K+ DFGL + +E K+ RFP KWTAPEA F+ KSDVWS+GI++ E+ T+ PYP ++EVI+ + G+RMP P + PD IY++++ CW A P +RPTF L ++ V
Sbjct: 377 HFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI-ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNH----YFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSV 541 HSP 2 Score: 88.5817 bits (218), Expect = 2.788e-55 Identity = 58/168 (34.52%), Postives = 87/168 (51.79%), Query Frame = 2
Query: 3764 FLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHV---PLTDPLPDNYQPPIHFQDXXXX-XXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
+ VKH++IK D Y + FP + L+ Y KN +G H+ P P P + +D R I++L ++GRG FG V KW + +VA K L+ FLQEA IM K RH ++V L VC+ Q+ P+ I+ E+M GSL ++L+ +G+
Sbjct: 211 YHVKHYRIKP--LDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCS--QEEPIYIVQEYMSKGSLLDFLREGDGR 374 HSP 3 Score: 62.003 bits (149), Expect = 3.793e-9 Identity = 41/138 (29.71%), Postives = 74/138 (53.62%), Query Frame = 1
Query: 3409 GPPGSYM---VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPS-RKENCFALSVRDFDEKK----KNFLGKAFSNKSQY 3798
G PG + V A Y Y + E+D+SF + M V++ + W RV ++ +GL+P N+V+++ + + R EA+KLL+ +GT+++RPS N ++LSV+D+++ + K++ K N Y
Sbjct: 90 GVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100505) HSP 1 Score: 149.058 bits (375), Expect = 2.788e-55 Identity = 67/170 (39.41%), Postives = 105/170 (61.76%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIV 4772
+ +I++ +++ GM YLES++++HRDL A N+L+ ++ K+ DFGL + +E K+ RFP KWTAPEA F+ KSDVWS+GI++ E+ T+ PYP ++EVI+ + G+RMP P + PD IY++++ CW A P +RPTF L ++ V
Sbjct: 377 HFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI-ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNH----YFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSV 541 HSP 2 Score: 88.5817 bits (218), Expect = 2.788e-55 Identity = 58/168 (34.52%), Postives = 87/168 (51.79%), Query Frame = 2
Query: 3764 FLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHV---PLTDPLPDNYQPPIHFQDXXXX-XXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
+ VKH++IK D Y + FP + L+ Y KN +G H+ P P P + +D R I++L ++GRG FG V KW + +VA K L+ FLQEA IM K RH ++V L VC+ Q+ P+ I+ E+M GSL ++L+ +G+
Sbjct: 211 YHVKHYRIKP--LDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCS--QEEPIYIVQEYMSKGSLLDFLREGDGR 374 HSP 3 Score: 62.003 bits (149), Expect = 3.793e-9 Identity = 41/138 (29.71%), Postives = 74/138 (53.62%), Query Frame = 1
Query: 3409 GPPGSYM---VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPS-RKENCFALSVRDFDEKK----KNFLGKAFSNKSQY 3798
G PG + V A Y Y + E+D+SF + M V++ + W RV ++ +GL+P N+V+++ + + R EA+KLL+ +GT+++RPS N ++LSV+D+++ + K++ K N Y
Sbjct: 90 GVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100504) HSP 1 Score: 149.058 bits (375), Expect = 2.788e-55 Identity = 67/170 (39.41%), Postives = 105/170 (61.76%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIV 4772
+ +I++ +++ GM YLES++++HRDL A N+L+ ++ K+ DFGL + +E K+ RFP KWTAPEA F+ KSDVWS+GI++ E+ T+ PYP ++EVI+ + G+RMP P + PD IY++++ CW A P +RPTF L ++ V
Sbjct: 377 HFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI-ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNH----YFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSV 541 HSP 2 Score: 88.5817 bits (218), Expect = 2.788e-55 Identity = 58/168 (34.52%), Postives = 87/168 (51.79%), Query Frame = 2
Query: 3764 FLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHV---PLTDPLPDNYQPPIHFQDXXXX-XXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
+ VKH++IK D Y + FP + L+ Y KN +G H+ P P P + +D R I++L ++GRG FG V KW + +VA K L+ FLQEA IM K RH ++V L VC+ Q+ P+ I+ E+M GSL ++L+ +G+
Sbjct: 211 YHVKHYRIKP--LDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCS--QEEPIYIVQEYMSKGSLLDFLREGDGR 374 HSP 3 Score: 62.003 bits (149), Expect = 3.793e-9 Identity = 41/138 (29.71%), Postives = 74/138 (53.62%), Query Frame = 1
Query: 3409 GPPGSYM---VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPS-RKENCFALSVRDFDEKK----KNFLGKAFSNKSQY 3798
G PG + V A Y Y + E+D+SF + M V++ + W RV ++ +GL+P N+V+++ + + R EA+KLL+ +GT+++RPS N ++LSV+D+++ + K++ K N Y
Sbjct: 90 GVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: src (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [Source:NCBI gene;Acc:325084]) HSP 1 Score: 171.4 bits (433), Expect = 5.992e-68 Identity = 83/169 (49.11%), Postives = 108/169 (63.91%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CPD ++++M+ CW +P +RPTF LQ L+
Sbjct: 357 KMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP------AECPDSLHELMLTCWRKEPEERPTFEYLQGFLE 518 HSP 2 Score: 79.337 bits (194), Expect = 5.992e-68 Identity = 59/165 (35.76%), Postives = 87/165 (52.73%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPP---IHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ Y ++ G H LTD P +PP + EI R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 200 VKHYKIRK--LDSGGFYITSRTQFSTLQQLVNHYRQHADGLCH-SLTDVCP-VLKPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMGQGSLLDFLKGDMGK 357 HSP 3 Score: 50.8322 bits (120), Expect = 5.992e-68 Identity = 29/108 (26.85%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + ++ + W + G +P+NYV+ D + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 89 ALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQAEEWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSVLDYDNVK 196
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: src (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [Source:NCBI gene;Acc:325084]) HSP 1 Score: 171.4 bits (433), Expect = 5.992e-68 Identity = 83/169 (49.11%), Postives = 108/169 (63.91%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CPD ++++M+ CW +P +RPTF LQ L+
Sbjct: 357 KMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP------AECPDSLHELMLTCWRKEPEERPTFEYLQGFLE 518 HSP 2 Score: 79.337 bits (194), Expect = 5.992e-68 Identity = 59/165 (35.76%), Postives = 87/165 (52.73%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPP---IHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ Y ++ G H LTD P +PP + EI R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 200 VKHYKIRK--LDSGGFYITSRTQFSTLQQLVNHYRQHADGLCH-SLTDVCP-VLKPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMGQGSLLDFLKGDMGK 357 HSP 3 Score: 50.8322 bits (120), Expect = 5.992e-68 Identity = 29/108 (26.85%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + ++ + W + G +P+NYV+ D + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 89 ALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQAEEWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSVLDYDNVK 196
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: src (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [Source:NCBI gene;Acc:325084]) HSP 1 Score: 171.4 bits (433), Expect = 1.996e-66 Identity = 83/169 (49.11%), Postives = 108/169 (63.91%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CPD ++++M+ CW +P +RPTF LQ L+
Sbjct: 363 KMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP------AECPDSLHELMLTCWRKEPEERPTFEYLQGFLE 524 HSP 2 Score: 79.7221 bits (195), Expect = 1.996e-66 Identity = 59/165 (35.76%), Postives = 87/165 (52.73%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPP---IHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ Y ++ G H LTD P +PP + EI R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 206 VKHYKIRK--LDSGGFYITSRTQFSTLQQLVNHYRQHADGLCH-SLTDVCP-VLKPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMGQGSLLDFLKGDMGK 363 HSP 3 Score: 45.4394 bits (106), Expect = 1.996e-66 Identity = 31/115 (26.96%), Postives = 57/115 (49.57%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVF-------DEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + ++ + WL L + G +P+NYV+ D + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 89 ALYDYESRTASDLSFRKGERLQIVNNTRKLNPREGDWWLARSLTTGE-SGYIPSNYVAPSDSIQAEEWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSVLDYDNVK 202
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: lyn (LYN proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040912-7]) HSP 1 Score: 167.933 bits (424), Expect = 8.637e-64 Identity = 83/183 (45.36%), Postives = 112/183 (61.20%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
K L ++I A+I+EGMAY+E + +HRDLRA N+LV++ L K+ADFGL + E ++ ++ +FP KWTAPEA FT KSD+WSFG+++YEI+T+ PYP EV+ V GYRMP PE +CP E+Y+IM CW P RPTF +Q LD A+ G Y Q
Sbjct: 336 KIQLPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIED-DQYTAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPE------NCPVELYEIMTTCWKNKPEDRPTFDYIQSVLDDFYT--ATEGQYQQQ 509 HSP 2 Score: 63.5438 bits (153), Expect = 8.637e-64 Identity = 54/165 (32.73%), Postives = 87/165 (52.73%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVR-GFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
+VKH++I+ N Y I+ + F DI ++I+ Y K G Q P EI++++I+++ ++G G FG V A + + +VA K L+ E FL+EA +M L+H ++V L V T+ + P+ II E+M GSL ++LKS G K
Sbjct: 177 VVKHYKIR---SLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSVEAFLEEANLMKTLQHDRLVRLYAVVTKTE--PIYIITEYMANGSLLDFLKSQAGSK 336 HSP 3 Score: 55.8398 bits (133), Expect = 8.637e-64 Identity = 34/115 (29.57%), Postives = 62/115 (53.91%), Query Frame = 1
Query: 3427 MVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKKKNFL 3768
+V A Y Y A D+ F+ E + ++E E W L K +G +P+NYV++ D +++I R +AE+ L+ + G+Y+IR S + ++LS+RD D + ++ +
Sbjct: 65 IVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKARSLTTRK-EGFIPSNYVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVV 178
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: blk (BLK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040724-106]) HSP 1 Score: 169.474 bits (428), Expect = 2.609e-63 Identity = 88/183 (48.09%), Postives = 110/183 (60.11%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
K LS++I M A+I+EGMAY+E + +HRDLRA NILV++ L K+ADFGL I E QE +FP KWTAPEA FT KSDVWSFGI++ EI+T+ PYP EVI + YRMP P+ CP E+Y IM CW P RPTF LQ+ L+ + A+ G Y Q
Sbjct: 312 KLKLSKLIDMTAQIAEGMAYIERKNYIHRDLRAANILVSETLHCKIADFGLARIIETEYTAQE--GAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTYGRVPYPGMTNPEVIRNLDRNYRMPCPDA------CPGELYDIMTKCWMEKPEDRPTFEYLQDTLNDFFI--ATEGQYEMQ 484 HSP 2 Score: 65.855 bits (159), Expect = 2.609e-63 Identity = 53/165 (32.12%), Postives = 86/165 (52.12%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNY-QPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
+VKH++I+ D Y F + L+++Y + G L +P Q P + EI RE ++++ ++G G FG V + +VA K L+ E E FLQEA +M +L+H ++V+L V T P+ I+ E+M GSL ++LK+D+G K
Sbjct: 154 VVKHYKIRA--LDNGGYYISPSTSFSSLQELVKYYSRTADGLCQR-LGNPCKSTAPQRPWAQDEWEIPRETLKLVKKLGAGQFGEVWMGFYKNNQKVAIKTLKEGTMEPEAFLQEANLMKQLQHERLVKLHAVVTRE---PIYIVTEYMANGSLLDFLKTDDGHK 312 HSP 3 Score: 50.8322 bits (120), Expect = 2.609e-63 Identity = 30/108 (27.78%), Postives = 61/108 (56.48%), Query Frame = 1
Query: 3427 MVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAW--REIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRD 3741
+V A+Y + +E D+ F+ + + +++ E WL L + +G +P+ YV++ VE W +++ R + E+LL+ G + G++++R S + F+LS+RD
Sbjct: 42 VVIAQYDFQPASENDLQFKKGDRLRIIKENGEWWLAKSLV-TGYEGFIPSTYVAR--AQTLQVERWFFKDMNRRDTERLLLAPGNKPGSFLVRESETTKGAFSLSIRD 146
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 167.548 bits (423), Expect = 1.605e-67 Identity = 82/166 (49.40%), Postives = 105/166 (63.25%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ L+
Sbjct: 310 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------DCPESLHDLMCQCWRKDPEERPTFEYLQAFLE 468 HSP 2 Score: 76.2554 bits (186), Expect = 1.605e-67 Identity = 54/172 (31.40%), Postives = 84/172 (48.84%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDPLP-----DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P P D ++ P R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + G+
Sbjct: 150 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSKDAWEIP---------RDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGR 307 HSP 3 Score: 56.6102 bits (135), Expect = 1.605e-67 Identity = 35/110 (31.82%), Postives = 58/110 (52.73%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWR--EIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W +S G +P+NYV+ D E W +I R EAE+LL+ + +GT+++R S + + LSV D+D +
Sbjct: 39 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANR 146
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 167.548 bits (423), Expect = 1.771e-67 Identity = 82/166 (49.40%), Postives = 105/166 (63.25%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ L+
Sbjct: 315 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------DCPESLHDLMCQCWRKDPEERPTFEYLQAFLE 473 HSP 2 Score: 76.6406 bits (187), Expect = 1.771e-67 Identity = 54/172 (31.40%), Postives = 84/172 (48.84%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDPLP-----DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P P D ++ P R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + G+
Sbjct: 155 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSKDAWEIP---------RDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGR 312 HSP 3 Score: 56.6102 bits (135), Expect = 1.771e-67 Identity = 35/110 (31.82%), Postives = 58/110 (52.73%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAW--REIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W +S G +P+NYV+ D E W +I R EAE+LL+ + +GT+++R S + + LSV D+D +
Sbjct: 44 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANR 151
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 167.162 bits (422), Expect = 1.829e-67 Identity = 82/166 (49.40%), Postives = 105/166 (63.25%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ L+
Sbjct: 358 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------DCPESLHDLMCQCWRKDPEERPTFEYLQAFLE 516 HSP 2 Score: 76.2554 bits (186), Expect = 1.829e-67 Identity = 54/172 (31.40%), Postives = 84/172 (48.84%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDPLP-----DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P P D ++ P R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + G+
Sbjct: 198 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSKDAWEIP---------RDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGR 355 HSP 3 Score: 56.9954 bits (136), Expect = 1.829e-67 Identity = 35/110 (31.82%), Postives = 58/110 (52.73%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAW--REIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W +S G +P+NYV+ D E W +I R EAE+LL+ + +GT+++R S + + LSV D+D +
Sbjct: 87 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANR 194
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 167.162 bits (422), Expect = 2.176e-67 Identity = 82/166 (49.40%), Postives = 105/166 (63.25%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ L+
Sbjct: 332 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------DCPESLHDLMCQCWRKDPEERPTFEYLQAFLE 490 HSP 2 Score: 76.2554 bits (186), Expect = 2.176e-67 Identity = 54/172 (31.40%), Postives = 84/172 (48.84%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDPLP-----DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P P D ++ P R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + G+
Sbjct: 172 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSKDAWEIP---------RDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGR 329 HSP 3 Score: 56.6102 bits (135), Expect = 2.176e-67 Identity = 35/110 (31.82%), Postives = 58/110 (52.73%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWR--EIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W +S G +P+NYV+ D E W +I R EAE+LL+ + +GT+++R S + + LSV D+D +
Sbjct: 61 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANR 168
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 167.162 bits (422), Expect = 2.178e-67 Identity = 82/166 (49.40%), Postives = 105/166 (63.25%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ L+
Sbjct: 308 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------DCPESLHDLMCQCWRKDPEERPTFEYLQAFLE 466 HSP 2 Score: 76.2554 bits (186), Expect = 2.178e-67 Identity = 54/172 (31.40%), Postives = 84/172 (48.84%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDPLP-----DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P P D ++ P R+++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + G+
Sbjct: 148 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSKDAWEIP---------RDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGR 305 HSP 3 Score: 56.6102 bits (135), Expect = 2.178e-67 Identity = 35/110 (31.82%), Postives = 58/110 (52.73%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWR--EIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W +S G +P+NYV+ D E W +I R EAE+LL+ + +GT+++R S + + LSV D+D +
Sbjct: 37 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANR 144
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Src (Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:98397]) HSP 1 Score: 166.777 bits (421), Expect = 3.905e-68 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 358 KYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 519 HSP 2 Score: 77.7962 bits (190), Expect = 3.905e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 201 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMNKGSLLDFLKGETGK 358 HSP 3 Score: 57.7658 bits (138), Expect = 3.905e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 90 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 197
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Src (Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:98397]) HSP 1 Score: 166.777 bits (421), Expect = 3.905e-68 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 358 KYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 519 HSP 2 Score: 77.7962 bits (190), Expect = 3.905e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 201 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMNKGSLLDFLKGETGK 358 HSP 3 Score: 57.7658 bits (138), Expect = 3.905e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 90 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 197
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Src (Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:98397]) HSP 1 Score: 166.777 bits (421), Expect = 3.905e-68 Identity = 82/169 (48.52%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW +P +RPTF LQ L+
Sbjct: 358 KYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 519 HSP 2 Score: 77.7962 bits (190), Expect = 3.905e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 201 VKHYKIRK--LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMNKGSLLDFLKGETGK 358 HSP 3 Score: 57.7658 bits (138), Expect = 3.905e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W ++ G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 90 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 197
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Lyn (LYN proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892]) HSP 1 Score: 168.318 bits (425), Expect = 4.277e-67 Identity = 86/183 (46.99%), Postives = 112/183 (61.20%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
K L ++I A+I+EGMAY+E + +HRDLRA N+LV++ L K+ADFGL + E NE ++ +FP KWTAPEA FT KSDVWSFGI++YEI+T+ PYP +V+ +S GYRMP E +CPDE+Y IM CW +RPTF LQ LD A+ G Y Q
Sbjct: 317 KVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIED-NEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRME------NCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYT--ATEGQYQQQ 490 HSP 2 Score: 68.5514 bits (166), Expect = 4.277e-67 Identity = 58/165 (35.15%), Postives = 88/165 (53.33%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVR-GFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
++KH++I+ N Y I+ R FP I +I+ Y+K G + Q P EI RE+I+++ ++G G FG V + + +VA K L+ + FL+EA +M L+H K+V L V T+ + P+ II EFM GSL ++LKSDEG K
Sbjct: 158 VIKHYKIR---SLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEE--PIYIITEFMAKGSLLDFLKSDEGGK 317 HSP 3 Score: 62.003 bits (149), Expect = 4.277e-67 Identity = 39/108 (36.11%), Postives = 61/108 (56.48%), Query Frame = 1
Query: 3427 MVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRK-ENCFALSVRDFD 3747
+V A Y Y D+SF+ E M VLE E W + + +SK +G +P+NYV+K + +++I R +AE+ L+ G G ++IR S + F+LSVRD+D
Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGE-WWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYD 152
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Lyn (LYN proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892]) HSP 1 Score: 168.318 bits (425), Expect = 4.759e-67 Identity = 86/183 (46.99%), Postives = 112/183 (61.20%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
K L ++I A+I+EGMAY+E + +HRDLRA N+LV++ L K+ADFGL + E NE ++ +FP KWTAPEA FT KSDVWSFGI++YEI+T+ PYP +V+ +S GYRMP E +CPDE+Y IM CW +RPTF LQ LD A+ G Y Q
Sbjct: 338 KVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIED-NEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRME------NCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYT--ATEGQYQQQ 511 HSP 2 Score: 68.5514 bits (166), Expect = 4.759e-67 Identity = 58/165 (35.15%), Postives = 88/165 (53.33%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVR-GFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
++KH++I+ N Y I+ R FP I +I+ Y+K G + Q P EI RE+I+++ ++G G FG V + + +VA K L+ + FL+EA +M L+H K+V L V T+ + P+ II EFM GSL ++LKSDEG K
Sbjct: 179 VIKHYKIR---SLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEE--PIYIITEFMAKGSLLDFLKSDEGGK 338 HSP 3 Score: 62.003 bits (149), Expect = 4.759e-67 Identity = 39/108 (36.11%), Postives = 61/108 (56.48%), Query Frame = 1
Query: 3427 MVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRK-ENCFALSVRDFD 3747
+V A Y Y D+SF+ E M VLE E W + + +SK +G +P+NYV+K + +++I R +AE+ L+ G G ++IR S + F+LSVRD+D
Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGE-WWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYD 173
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P42687|SPK1_GIRTI (Tyrosine-protein kinase SPK-1 OS=Girardia tigrina OX=6162 PE=2 SV=1) HSP 1 Score: 312.383 bits (799), Expect = 1.886e-156 Identity = 147/186 (79.03%), Postives = 165/186 (88.71%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQSK 4811
KKTNL+QM+HMMAEISEGMAYLESEKVVHRDLRADNILVA+DLT KVADFGLTE+T+G+ +QEKK LRFPYKWTAPEAAKSKVFTSKSDVWS+GIVM+EILTW++ PYPD PAKEVI+KVS GYRMPNPE FI GV CPDEIYKIMI CW A+P +RPTF LQE++D LIV+ +N YYS SK
Sbjct: 312 KKTNLNQMVHMMAEISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILTWASSPYPDIPAKEVIEKVSKGYRMPNPEKFITGVCCPDEIYKIMIWCWDANPEKRPTFLVLQEKMDLLIVDTLTNNAYYSHSK 497 HSP 2 Score: 265.774 bits (678), Expect = 1.886e-156 Identity = 138/171 (80.70%), Postives = 158/171 (92.40%), Query Frame = 2
Query: 3749 KRKKIFLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKKN 4261
++KKI +VKHFQIK ++K YS+N+R FP+ILTLIQFYEKNGIGN+H+PLTDP+PDNYQPP+HFQDIEINRENIEILNEIGRG FGSVH+AKWGR+YEVAAKMLQS+KAEREKF+ EAKIMHKLRHRKIVELLGVCTEPQDMPM+IIVE+MK GSLKEYLK+ +GKK
Sbjct: 144 EKKKICIVKHFQIKTLQDEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDPMPDNYQPPVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKT 314 HSP 3 Score: 209.92 bits (533), Expect = 7.296e-57 Identity = 100/132 (75.76%), Postives = 114/132 (86.36%), Query Frame = 1
Query: 3397 KAYEGPPGSYMVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAFSNKS 3792
KAYEGPPGSYMVKAKYKY A+ +TDISFE+KE+M+VLE FDE WL+V + +GLVP+NYVSKQDGSPQSVEAWREIQRWEAEK LM++GLQKGTYIIRPSRKEN +ALSVRDFDEKKK + K F K+
Sbjct: 27 KAYEGPPGSYMVKAKYKYAASGDTDISFEEKEIMYVLEQFDEFWLKVVKQKDNKEGLVPSNYVSKQDGSPQSVEAWREIQRWEAEKSLMKIGLQKGTYIIRPSRKENSYALSVRDFDEKKKICIVKHFQIKT 158
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P63185|SRC_RSVSE (Tyrosine-protein kinase transforming protein Src OS=Rous sarcoma virus (strain Schmidt-Ruppin E) OX=270623 GN=V-SRC PE=1 SV=3) HSP 1 Score: 169.859 bits (429), Expect = 1.880e-68 Identity = 84/168 (50.00%), Postives = 105/168 (62.50%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQL 4757
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ QL
Sbjct: 356 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPP------ECPESLHDLMSQCWRRDPEERPTFEYLQAQL 516 HSP 2 Score: 79.7221 bits (195), Expect = 1.880e-68 Identity = 56/172 (32.56%), Postives = 87/172 (50.58%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH+K+V+L V +E P+ I++E+M GSL ++LK + GK
Sbjct: 199 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHKKLVQLYAVVSEE---PIYIVIEYMSKGSLLDFLKGEMGK 356 HSP 3 Score: 56.225 bits (134), Expect = 1.880e-68 Identity = 33/108 (30.56%), Postives = 56/108 (51.85%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + +W + G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 88 ALYDYESWIETDLSFKKGERLQIVNNTEGNWWLAHSVTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAK 195
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P00524|SRC_RSVSA (Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA OX=269446 GN=V-SRC PE=1 SV=5) HSP 1 Score: 171.014 bits (432), Expect = 2.936e-68 Identity = 84/168 (50.00%), Postives = 105/168 (62.50%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQL 4757
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ QL
Sbjct: 356 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPP------ECPESLHDLMCQCWRRDPEERPTFEYLQAQL 516 HSP 2 Score: 77.7962 bits (190), Expect = 2.936e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 199 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGK 356 HSP 3 Score: 56.6102 bits (135), Expect = 2.936e-68 Identity = 33/108 (30.56%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W + G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 88 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAK 195
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P00525|SRC_AVISR (Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) OX=11894 GN=V-SRC PE=1 SV=3) HSP 1 Score: 171.014 bits (432), Expect = 2.936e-68 Identity = 84/168 (50.00%), Postives = 105/168 (62.50%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQL 4757
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ QL
Sbjct: 356 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPP------ECPESLHDLMCQCWRRDPEERPTFEYLQAQL 516 HSP 2 Score: 77.7962 bits (190), Expect = 2.936e-68 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 199 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGK 356 HSP 3 Score: 56.6102 bits (135), Expect = 2.936e-68 Identity = 33/108 (30.56%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W + G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 88 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAK 195
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P00523|SRC_CHICK (Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus OX=9031 GN=SRC PE=1 SV=4) HSP 1 Score: 168.318 bits (425), Expect = 1.848e-67 Identity = 83/169 (49.11%), Postives = 106/169 (62.72%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV ++L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++ +M CW DP +RPTF LQ L+
Sbjct: 356 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKDPEERPTFEYLQAFLE 517 HSP 2 Score: 77.411 bits (189), Expect = 1.848e-67 Identity = 56/172 (32.56%), Postives = 85/172 (49.42%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSH-----VPLTDP-----LPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ +Y K+ G H P + P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK + GK
Sbjct: 199 VKHYKIRK--LDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIP---------RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKGEMGK 356 HSP 3 Score: 56.6102 bits (135), Expect = 1.848e-67 Identity = 33/108 (30.56%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + ETD+SF+ E + ++ + W + G +P+NYV+ D + +I R E+E+LL+ +GT+++R S + + LSV DFD K
Sbjct: 88 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAK 195
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A094ZT02 (Tyrosine-protein kinase OS=Schistosoma haematobium OX=6185 GN=MS3_05644 PE=3 SV=1) HSP 1 Score: 173.711 bits (439), Expect = 3.905e-94 Identity = 83/165 (50.30%), Postives = 110/165 (66.67%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQE 4751
K L +I +MA+I+ GM+YLE VHRDLRA NILV D +VKV+DFGL +I ++++ N +FP KWTAPEAA +F+ KSDVWSFGI+MYEI+T+ PYP ++ + +V GYR+P P T P CPD++Y +M CW A P RPTF SL +
Sbjct: 389 KLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKII--SDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHT--PEHPCPDDLYNLMRKCWDARPENRPTFRSLYD 549 HSP 2 Score: 127.102 bits (318), Expect = 3.905e-94 Identity = 72/169 (42.60%), Postives = 114/169 (67.46%), Query Frame = 2
Query: 3755 KKIFLVKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
K +++VKH++I+ I D N + I++R FP+I LI +Y + G L+ P P Y+PP+ F+D EINR++I + ++G+G FG V+ AKW + EVA KM + +R +F++EA++MH H +IV+LLGVCTEP+D P+ II E M+ G+L ++L+++EG K
Sbjct: 225 KNMWVVKHYRIR--ILDNNGGFFISIRTTFPNIQDLINYYTVHPDGLC-CRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHK 389 HSP 3 Score: 98.9821 bits (245), Expect = 3.905e-94 Identity = 45/117 (38.46%), Postives = 72/117 (61.54%), Query Frame = 1
Query: 3430 VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAF 3780
V+A Y Y + D+SF+ ++MFV+ + W ++ + G +P+NYV DG P S++AW +I R EA++ L+ VG KGTY+IRPS + +ALSVR +D +K ++ K +
Sbjct: 117 VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHY 233
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A430QHK8 (Tyrosine-protein kinase OS=Schistosoma bovis OX=6184 GN=DC041_0007532 PE=3 SV=1) HSP 1 Score: 173.326 bits (438), Expect = 6.755e-94 Identity = 83/165 (50.30%), Postives = 110/165 (66.67%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQE 4751
K L +I +MA+I+ GM+YLE VHRDLRA NILV D +VKV+DFGL +I ++++ N +FP KWTAPEAA +F+ KSDVWSFGI+MYEI+T+ PYP ++ + +V GYR+P P T P CPD++Y +M CW A P RPTF SL +
Sbjct: 305 KLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKII--SDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHT--PEHPCPDDLYNLMRKCWDARPENRPTFRSLYD 465 HSP 2 Score: 127.102 bits (318), Expect = 6.755e-94 Identity = 72/169 (42.60%), Postives = 114/169 (67.46%), Query Frame = 2
Query: 3755 KKIFLVKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
K +++VKH++I+ I D N + I++R FP+I LI +Y + G L+ P P Y+PP+ F+D EINR++I + ++G+G FG V+ AKW + EVA KM + +R +F++EA++MH H +IV+LLGVCTEP+D P+ II E M+ G+L ++L+++EG K
Sbjct: 141 KNMWVVKHYRIR--ILDNNGGFFISIRTTFPNIQDLINYYTVHPDGLC-CRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHK 305 HSP 3 Score: 98.5969 bits (244), Expect = 6.755e-94 Identity = 45/117 (38.46%), Postives = 72/117 (61.54%), Query Frame = 1
Query: 3430 VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAF 3780
V+A Y Y + D+SF+ ++MFV+ + W ++ + G +P+NYV DG P S++AW +I R EA++ L+ VG KGTY+IRPS + +ALSVR +D +K ++ K +
Sbjct: 33 VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHY 149
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A3Q0KBZ0 (Tyrosine-protein kinase OS=Schistosoma mansoni OX=6183 PE=3 SV=1) HSP 1 Score: 173.711 bits (439), Expect = 1.054e-93 Identity = 83/165 (50.30%), Postives = 110/165 (66.67%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQE 4751
K L +I +MA+I+ GM+YLE VHRDLRA NILV D +VKV+DFGL +I ++++ N +FP KWTAPEAA +F+ KSDVWSFGI+MYEI+T+ PYP ++ + +V GYR+P P T P CPD++Y +M CW A P RPTF SL +
Sbjct: 389 KLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKII--SDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHT--PEHPCPDDLYNLMRKCWDARPENRPTFRSLYD 549 HSP 2 Score: 126.716 bits (317), Expect = 1.054e-93 Identity = 71/169 (42.01%), Postives = 114/169 (67.46%), Query Frame = 2
Query: 3755 KKIFLVKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
K +++VKH++I+ I D N + I++R FP+I L+ +Y + G L+ P P Y+PP+ F+D EINR++I + ++G+G FG V+ AKW + EVA KM + +R +F++EA++MH H +IV+LLGVCTEP+D P+ II E M+ G+L ++L+++EG K
Sbjct: 225 KNMWVVKHYRIR--ILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLC-CRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHK 389 HSP 3 Score: 97.8265 bits (242), Expect = 1.054e-93 Identity = 45/117 (38.46%), Postives = 71/117 (60.68%), Query Frame = 1
Query: 3430 VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAF 3780
V+A Y Y + D+SF+ ++MFV+ + W ++ + G +P+NYV DG P S++AW I R EA++ L+ VG KGTY+IRPS + +ALSVR +D +K ++ K +
Sbjct: 117 VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGISGYIPSNYVCLNDGLPTSLDAWYNIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHY 233
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: G4LWG5 (Tyrosine-protein kinase OS=Schistosoma mansoni OX=6183 GN=Smp_006920 PE=3 SV=1) HSP 1 Score: 173.326 bits (438), Expect = 2.014e-93 Identity = 83/165 (50.30%), Postives = 110/165 (66.67%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQE 4751
K L +I +MA+I+ GM+YLE VHRDLRA NILV D +VKV+DFGL +I ++++ N +FP KWTAPEAA +F+ KSDVWSFGI+MYEI+T+ PYP ++ + +V GYR+P P T P CPD++Y +M CW A P RPTF SL +
Sbjct: 305 KLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKII--SDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHT--PEHPCPDDLYNLMRKCWDARPENRPTFRSLYD 465 HSP 2 Score: 126.716 bits (317), Expect = 2.014e-93 Identity = 71/169 (42.01%), Postives = 114/169 (67.46%), Query Frame = 2
Query: 3755 KKIFLVKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
K +++VKH++I+ I D N + I++R FP+I L+ +Y + G L+ P P Y+PP+ F+D EINR++I + ++G+G FG V+ AKW + EVA KM + +R +F++EA++MH H +IV+LLGVCTEP+D P+ II E M+ G+L ++L+++EG K
Sbjct: 141 KNMWVVKHYRIR--ILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLC-CRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHK 305 HSP 3 Score: 97.4413 bits (241), Expect = 2.014e-93 Identity = 45/117 (38.46%), Postives = 71/117 (60.68%), Query Frame = 1
Query: 3430 VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAF 3780
V+A Y Y + D+SF+ ++MFV+ + W ++ + G +P+NYV DG P S++AW I R EA++ L+ VG KGTY+IRPS + +ALSVR +D +K ++ K +
Sbjct: 33 VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGISGYIPSNYVCLNDGLPTSLDAWYNIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHY 149
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: C1LGZ6 (Tyrosine-protein kinase OS=Schistosoma japonicum OX=6182 GN=fyn-prov PE=2 SV=1) HSP 1 Score: 173.326 bits (438), Expect = 1.273e-92 Identity = 83/165 (50.30%), Postives = 110/165 (66.67%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQE 4751
K L +I +MA+I+ GM+YLE VHRDLRA NILV D +VKV+DFGL +I ++++ N +FP KWTAPEAA +F+ KSDVWSFGI+MYEI+T+ PYP ++ + +V GYR+P P T P CPD++Y +M CW A P RPTF SL +
Sbjct: 389 KLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKII--SDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHT--PEHPCPDDLYNLMRKCWDARPENRPTFRSLYD 549 HSP 2 Score: 126.716 bits (317), Expect = 1.273e-92 Identity = 71/169 (42.01%), Postives = 114/169 (67.46%), Query Frame = 2
Query: 3755 KKIFLVKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
K +++VKH++I+ I D N + I++R FP+I L+ +Y + G L+ P P Y+PP+ F+D EINR++I + ++G+G FG V+ AKW + EVA KM + +R +F++EA++MH H +IV+LLGVCTEP+D P+ II E M+ G+L ++L+++EG K
Sbjct: 225 KNMWVVKHYRIR--ILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLC-CRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHK 389 HSP 3 Score: 95.1301 bits (235), Expect = 1.273e-92 Identity = 44/117 (37.61%), Postives = 70/117 (59.83%), Query Frame = 1
Query: 3430 VKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAF 3780
V+A Y Y + D+ F+ ++MFV+ + W + + G +P+NYV DG P S++AW +I R EA++ L+ VG KGTY+IRPS + +ALSVR +D +K ++ K +
Sbjct: 117 VRALYSYQGHNQDDLPFQKGDIMFVVSGMSDAWWFARHAETGMSGYIPSNYVCLDDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHY 233
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: SRC (proto-oncogene tyrosine-protein kinase Src-like [Source:NCBI gene;Acc:103042998]) HSP 1 Score: 169.474 bits (428), Expect = 1.132e-67 Identity = 83/171 (48.54%), Postives = 108/171 (63.16%), Query Frame = 3
Query: 4248 KEKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP ++++M+ CW +P +RPTF LQ L+
Sbjct: 357 KGKFLRLPQLVDMASQIAAGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELATKGRVPYPGMVNREVLDQVERGYRMPCP------AECPSSMHELMLSCWRKEPEERPTFEYLQGFLE 520 HSP 2 Score: 78.1814 bits (191), Expect = 1.132e-67 Identity = 57/173 (32.95%), Postives = 86/173 (49.71%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP-----------DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
+KH++I+ D Y + F + L+ Y + G HV LTD P D ++ P RE++ + ++G+GCFG V W VA K L+ E FL+EA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D+GK
Sbjct: 202 IKHYKIRK--LDSGGFYITSRTQFTSLQQLVLHYRTHADGLCHV-LTDICPMLKPQTQGLARDAWEIP---------RESLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKRGTMSPEAFLEEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSQGSLLDFLKGDKGK 359 HSP 3 Score: 52.373 bits (124), Expect = 1.132e-67 Identity = 33/123 (26.83%), Postives = 59/123 (47.97%), Query Frame = 1
Query: 3415 PGSYMVK--------AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
PGS M A Y Y + D++F+ E + +L + W + G +P+NYV+ D + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 76 PGSIMSPQRGVTTFVALYDYESRTTADLTFKKGERLQILNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQAEEWFFGKITRRDSERLLLNIQNRRGTFLVRESETTKGAYCLSVLDYDNMK 198
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000007450.2 (YES proto-oncogene 1, Src family tyrosine kinase [Source:NCBI gene;Acc:103026537]) HSP 1 Score: 160.614 bits (405), Expect = 2.118e-67 Identity = 75/161 (46.58%), Postives = 105/161 (65.22%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTF 4736
K L Q++ M A+IS+GMA++E +HRDLRA NILV D++ K+ADFGL + E NE ++ +FP KWTAPEAA F+ KSDVWSFGI++ E++T PYP +EV+++V GYRMP P CP ++++M+ CW +P +RPTF
Sbjct: 369 KVLKLPQLVDMAAQISDGMAFIERMNYIHRDLRAANILVTDNMVCKIADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGKFSIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVDRGYRMPCPPA------CPASLHELMLQCWRREPDERPTF 522 HSP 2 Score: 78.5666 bits (192), Expect = 2.118e-67 Identity = 60/167 (35.93%), Postives = 82/167 (49.10%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXX-----GRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH+ KV D Y F + +LI+ Y + G H LT P +P H Q + + I + G+GCFG V W + +VA K L+ E FLQEA+IM KLRH K+V+L V ++ P+ I+ EFM GSL ++LK EGK
Sbjct: 212 VKHY--KVRTLDSGGYYITTRAQFSTLQSLIKHYTAHADGLCHR-LTGVCP-TVRP--HTQGLAKDAWEISRDSLSLEVKLGQGCFGEVWMGTWKSSTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHDKLVQLYAVVSQE---PIYIVTEFMSKGSLLDFLKEGEGK 369 HSP 3 Score: 60.077 bits (144), Expect = 2.118e-67 Identity = 34/108 (31.48%), Postives = 60/108 (55.56%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y A D+SF+ E ++ + W +S LQG +P+NYV+ D + ++ R +AE+LL++ G+Q+G +++R S + F+LS+ D++E K
Sbjct: 101 ALYDYEARTTDDLSFKKGERFQIINNTEGDWWEACSLSSGLQGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLQPGIQRGMFLMRESETTKGAFSLSICDWEEDK 208
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: src (proto-oncogene tyrosine-protein kinase Src [Source:NCBI gene;Acc:103038924]) HSP 1 Score: 169.474 bits (428), Expect = 2.625e-67 Identity = 82/169 (48.52%), Postives = 107/169 (63.31%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFG+++ E+ T PYP +EV+D+V GYRMP P CPD ++ +M+ CW +P +RPTF LQ L+
Sbjct: 368 KILRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCP------AECPDSLHDLMLTCWRKEPEERPTFEYLQGFLE 529 HSP 2 Score: 80.1073 bits (196), Expect = 2.625e-67 Identity = 59/173 (34.10%), Postives = 86/173 (49.71%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP-----------DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F ++ L+ Y K+ G H LTD P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 211 VKHYKIRK--LDSGGFYITSRTQFSNLQQLVSHYRKHADGLCHF-LTDVCPVLKPQTQGLARDAWEIP---------RESLRLDLKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMGQGSLLDFLKGDMGK 368 HSP 3 Score: 49.6766 bits (117), Expect = 2.625e-67 Identity = 33/118 (27.97%), Postives = 59/118 (50.00%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWR----------EIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + ++ + W + G +P+NYV+ D S Q+ + R +I R ++E+LL+ + ++GT+++R S + + LSV DFD K
Sbjct: 91 ALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSD-SIQAEDHLRLTLEKRWYFGKITRRDSERLLLSLDNRRGTFLVRESETTKGAYCLSVLDFDNVK 207
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: src (proto-oncogene tyrosine-protein kinase Src [Source:NCBI gene;Acc:103038924]) HSP 1 Score: 169.474 bits (428), Expect = 7.800e-67 Identity = 82/169 (48.52%), Postives = 107/169 (63.31%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFG+++ E+ T PYP +EV+D+V GYRMP P CPD ++ +M+ CW +P +RPTF LQ L+
Sbjct: 365 KILRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCP------AECPDSLHDLMLTCWRKEPEERPTFEYLQGFLE 526 HSP 2 Score: 80.1073 bits (196), Expect = 7.800e-67 Identity = 59/173 (34.10%), Postives = 86/173 (49.71%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP-----------DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F ++ L+ Y K+ G H LTD P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 208 VKHYKIRK--LDSGGFYITSRTQFSNLQQLVSHYRKHADGLCHF-LTDVCPVLKPQTQGLARDAWEIP---------RESLRLDLKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMGQGSLLDFLKGDMGK 365 HSP 3 Score: 47.7506 bits (112), Expect = 7.800e-67 Identity = 31/114 (27.19%), Postives = 55/114 (48.25%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFV------LEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + + L + W + G +P+NYV+ D + +I R ++E+LL+ + ++GT+++R S + + LSV DFD K
Sbjct: 91 ALYDYESRTASDLSFRKGERLQIVNNTRKLNCREGDWWLARSLTTGESGYIPSNYVAPSDSIQAEEWYFGKITRRDSERLLLSLDNRRGTFLVRESETTKGAYCLSVLDFDNVK 204
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: lyn (tyrosine-protein kinase Lyn-like [Source:NCBI gene;Acc:103026730]) HSP 1 Score: 167.933 bits (424), Expect = 2.100e-66 Identity = 84/183 (45.90%), Postives = 111/183 (60.66%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
K L ++I A+I+EGMAY+E + +HRDLRA N+LV++ L K+ADFGL + E ++ ++ +FP KWTAPEA FT KSD+WSFGI++YEI+T+ PYP EV+ V GYRMP PE+ CP E+Y IM CW P RPTF +Q LD A+ G Y Q
Sbjct: 341 KLQLPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSESLLCKIADFGLARVIED-DQYTAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGILLYEIITYGKIPYPGMSNGEVMTSVQRGYRMPRPES------CPTELYDIMNTCWKNKPDDRPTFDYIQSVLDDFYT--ATEGQYQQQ 514 HSP 2 Score: 71.633 bits (174), Expect = 2.100e-66 Identity = 59/167 (35.33%), Postives = 86/167 (51.50%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIG---NSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
+VKH++I+ D Y FPDI+ +I Y K G P P Q P EI++E+I+++ ++G G FG V A + +VA K L+ E FL+EA +M L+H ++V L V T+ + P+ II EFM GSL ++LKSD G K
Sbjct: 182 VVKHYKIRS--LDNGGYYISPKITFPDIIKMIHHYHKQADGLCRKLERPCEKP---KAQKPWDKDAWEISKESIKMVKKLGAGQFGEVWMAYYNNTTKVAVKTLKPGTMSVEAFLEEANLMKTLQHERLVRLYAVVTKIE--PIYIITEFMANGSLLDFLKSDAGSK 341 HSP 3 Score: 56.6102 bits (135), Expect = 2.100e-66 Identity = 40/112 (35.71%), Postives = 59/112 (52.68%), Query Frame = 1
Query: 3415 PGSYMVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAW--REIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRD 3741
PG +V A Y Y A D+ F+ E + VLE E W L K +G +P+NYV++ D E W +EI R +AE+ L+ + G Y+IR S + ++LS+RD
Sbjct: 67 PGK-IVIALYPYEAIHTDDLGFKKGEKLRVLEEHGEWWKAKSLSTRK-EGFIPSNYVAQADT--METEEWFFKEITRKDAERQLLAPANKPGAYLIRESETSKGSYSLSIRD 174
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: clul1 (clusterin-like 1 (retinal) [Source:ZFIN;Acc:ZDB-GENE-031118-57]) HSP 1 Score: 168.318 bits (425), Expect = 3.484e-66 Identity = 80/166 (48.19%), Postives = 109/166 (65.66%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E +HRDLRA NILV D+L K+ADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E++T PYP +EV+++V GYRMP P + CP+ ++++M+ CW DP +RPTF LQ L+
Sbjct: 299 KLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLICKIADFGLARLIED-NEYTARQGAKFPIKWTAPEAAMFGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPPS------CPESLHELMMQCWKKDPEERPTFEYLQAFLE 457 HSP 2 Score: 74.7146 bits (182), Expect = 3.484e-66 Identity = 55/164 (33.54%), Postives = 88/164 (53.66%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSH-VPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ + N Y I R F + L+Q Y ++ G + + L P + E+ R+++++ ++G+GCFG V W +VA K L+ E FL+EA+IM KLRH K+V+L V +E P+ I+ EFM GSL ++LK +G+
Sbjct: 139 VKHYKIR---KLDNGGYYITTRAQFDTLQKLVQHYSEHADGLCYKLTLVCPNEKPQTQGLARDAWEMPRDSLKLELKLGQGCFGEVWAGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE---PIYIVTEFMSKGSLLDFLKEGDGR 296 HSP 3 Score: 50.0618 bits (118), Expect = 3.484e-66 Identity = 35/124 (28.23%), Postives = 62/124 (50.00%), Query Frame = 1
Query: 3418 GSYMVKAKYKYTATAETDISFEDKEVMFVLE-------VFDE-HWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKKKN 3762
G + A Y Y A + D+SF E ++ V+ E W ++ +G +P+NYV+ D + ++ R +AE+ L+ G +GT++IR S + ++LS+RD+DE K +
Sbjct: 14 GVTLFVALYDYDARTQDDLSFRKGEKFQIINNTIEVAVVYREGDWWEARSLSTGNKGYIPSNYVAPADSVQAEEWYFGKVSRKDAERQLLCPGNPRGTFLIRESETTKGAYSLSIRDWDEVKGD 137
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72]) HSP 1 Score: 164.466 bits (415), Expect = 6.237e-64 Identity = 82/180 (45.56%), Postives = 111/180 (61.67%), Query Frame = 3
Query: 4266 LSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQ 4805
+ +MI M A+I+EGMA++E + +HRDLRA NILV + L K+ADFGL I E NE ++ +FP KWTAPEA F+ KSDVWSFGI++ EI+T+ PYP +VI ++ GYRMP PE P ++Y +M+DCW P +RPTF LQ L+ ++ G Y Q
Sbjct: 275 MPKMIDMAAQIAEGMAFIERKNYIHRDLRAANILVNEQLASKIADFGLARIIED-NEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEIITFGRIPYPGMSNSDVIRQLERGYRMPCPE------QAPKQLYGVMMDCWKERPEERPTFEYLQGVLEDFFT--STEGQYQQQ 445 HSP 2 Score: 66.6254 bits (161), Expect = 6.237e-64 Identity = 54/163 (33.13%), Postives = 82/163 (50.31%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVR-GFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEG 4252
+V+H++I+ N Y I+ R FPD+ LIQ Y + G L + Q EI R+++++ +G G FG V + +VA K ++ E FL EA +M L+H ++V L V T+ P+ I+ EFM+ GSL +YLKS EG
Sbjct: 114 VVRHYKIRTL---DNGGYFISARLTFPDLFALIQHYTAHSDGLCQKLLRPCVSKKPQQLWEKDAWEIPRDSLKLSKRLGAGQFGEVWMGIYNNRTKVAIKTMKPGSMSPEAFLDEANLMKTLQHPRLVRLYAVVTQE---PIYIVTEFMENGSLLDYLKSTEG 270 HSP 3 Score: 53.9138 bits (128), Expect = 6.237e-64 Identity = 32/108 (29.63%), Postives = 57/108 (52.78%), Query Frame = 1
Query: 3427 MVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFD 3747
+V A Y + D+ F+ + M +++ E W+ EL + +G +P+NYV+K + + + R E E+LL+ G G Y++R S + ++LSVRD+D
Sbjct: 2 LVVALYDFEQLNPDDMGFKKGDKMRIIQERGEWWM-AELMDGSHKGYIPSNYVAKANSLETEEWFFSGVSRKEGERLLLAPGNSIGAYLLRDSESNKGSYSLSVRDYD 108
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 157.918 bits (398), Expect = 8.979e-62 Identity = 76/171 (44.44%), Postives = 106/171 (61.99%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEI--TEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K+ +++ M +I+ GMAYLES+ +HRDL A NILV + KVADFGL I +E + K + P KWTAPEA F+ KSDVWSFGI++YE++T+ PYP+ EV+ ++ GYRMP P+ +CP Y IM++CW+ +RPTF +LQ +LD
Sbjct: 279 KQLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPD------NCPPLFYSIMLECWNKKEEERPTFETLQWRLD 443 HSP 2 Score: 74.7146 bits (182), Expect = 8.979e-62 Identity = 54/178 (30.34%), Postives = 94/178 (52.81%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVR-GFPDILTLIQFYEKNGIG--------------NSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
VKH++I+ D+N + I+ R F +++ L+Q+Y+ N G + + L+ D ++ P R +I++ +G G FG V + W + VA K L+ ++E+F+ EA+IM +LRH +++L VC+ Q+ P+ II E M+ GSL +YL+ GK+
Sbjct: 116 VKHYRIRQ--LDENGGFFISRRVTFQNLIELVQYYKSNSDGLCMALQKPCVVIEAPTTIGLSYNTVDKWEIP---------RASIQLQKRLGAGMFGEVWQGLWNNSTLVAVKTLKPGAMKKEEFIGEAQIMKQLRHANLIQLYAVCS--QEEPIYIITELMRHGSLLDYLRGPLGKQ 280 HSP 3 Score: 45.4394 bits (106), Expect = 8.979e-62 Identity = 34/114 (29.82%), Postives = 60/114 (52.63%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNS-------KLQGLVPANYVSKQDGSPQSVEA----WREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRD 3741
A Y Y D+SF++ E++ V + + W + K + +G +PANYV++ QS++A + +I+R +AEK L+ G ++IR S ++ ++LSVRD
Sbjct: 3 ALYDYDGRTNEDLSFKEGELLEVTDKTNSDWWYAQKKTASTSNERYNTRGYIPANYVAEY----QSLDAEPWFFGDIKRADAEKYLLADVNTTGAFLIRQSESRKTDYSLSVRD 112
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006670.1 (pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene:ENSPMAG00000006016.1 transcript:ENSPMAT00000006670.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 170.629 bits (431), Expect = 1.023e-59 Identity = 80/180 (44.44%), Postives = 116/180 (64.44%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNL--RFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASN 4787
+ +L +++ M A+++ GMAYLE++ +HRDL A NILVA+ KVADFGL + + +NE++ + + +FP KWTAPEAA F+ KSDVWSFG++++EI+T+ PYP EV+ V GYRMP P PG CP Y +M++CW+ D RPTF +LQ QL+ + +N
Sbjct: 204 RSLDLVELVDMAAQVAAGMAYLEAQNYIHRDLAARNILVAEHNACKVADFGLARVIKMSNEDEYEARVGSKFPIKWTAPEAANYNRFSIKSDVWSFGVLLHEIITYGKLPYPGQTNAEVLAAVDRGYRMPCP----PG--CPQAFYDLMLECWNVDDQARPTFETLQWQLEDFFSQEGTN 377 HSP 2 Score: 79.7221 bits (195), Expect = 1.023e-59 Identity = 53/177 (29.94%), Postives = 91/177 (51.41%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIG----------NSHVP----LTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
VKH++I+V +K + + F + L+Q Y ++ G +P L+ + D ++ P R +++++ +G G FG V + W + VA K L+ +R+ FL+EA++M +LRH K+++L VCT Q+ P+ II E M GSL YL++ EG+
Sbjct: 42 VKHYKIRV--LEKGSFFITRRNQFATLRDLVQSYSRDANGLCVTLNQPCLKKEMPQTEGLSSDMADKWEIP---------RSSVQLVKRLGAGQFGEVWQGLWNKTTPVAIKTLKQGTMDRDDFLREAQLMKRLRHPKLIQLYAVCT--QEEPIYIITELMSNGSLANYLQTPEGRS 205
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 172.17 bits (435), Expect = 1.675e-56 Identity = 80/170 (47.06%), Postives = 111/170 (65.29%), Query Frame = 3
Query: 4266 LSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVE 4775
+ +I+M +++ GMAYLE++ +HRDL A NILV D+LT KVADFGL + + +E ++ +FP KWTAPEAA FT KSDVWSFGI++YEI+T+ PY EV++++ GYRMP P +CP + Y IM +CWH + A RP+F L QL+ LI +
Sbjct: 217 MCHLINMAVQVASGMAYLEAQNYIHRDLAARNILVGDNLTCKVADFGLARVIKD-DEYIAREGGKFPVKWTAPEAANYSRFTIKSDVWSFGILLYEIVTYGKVPYAGMTNAEVLEELEHGYRMPCP------TNCPRDFYSIMYNCWHKEEACRPSFLQLDHQLEDLITD 379 HSP 2 Score: 67.3958 bits (163), Expect = 1.675e-56 Identity = 35/85 (41.18%), Postives = 49/85 (57.65%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEG 4252
G G FG V++ W + VA K L+ E+FL EA IM + H +++L VCT + P+ II E M GSL +YL++DEG
Sbjct: 130 GAGQFGEVYEGLWNKTTRVAVKTLKPGAMVPEEFLAEAHIMKRFTHCNLIQLYAVCTTEE--PIYIITELMVNGSLLQYLQNDEG 212
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 69.707 bits (169), Expect = 6.105e-16 Identity = 38/129 (29.46%), Postives = 71/129 (55.04%), Query Frame = 3
Query: 4272 QMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGL-TEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGY-RMPNPETF 4652
Q+ +++ E +G+ +L + ++HRD+++DN+L+ VK+ DFG +T+ ++ + PY W APE K + + K DVWS GI+ E+L P + P K + ++G ++ +PE+
Sbjct: 669 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTD--KRSKRATMVGTPY-WMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESL 794 HSP 2 Score: 32.7278 bits (73), Expect = 6.105e-16 Identity = 18/68 (26.47%), Postives = 34/68 (50.00%), Query Frame = 2
Query: 4061 KMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKKNE 4264
+M+ S + +E + E +M RH+ IV L D + +++EFM+ GSL + +++ N
Sbjct: 595 QMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDD-LWVVMEFMEGGSLTDIIENSPTNDNS 661
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 67.3958 bits (163), Expect = 5.710e-15 Identity = 55/181 (30.39%), Postives = 90/181 (49.72%), Query Frame = 3
Query: 4221 L*KSI*NQMKEKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKN--LRFPYKWTAPEAAKSKV--FTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCP--DEIYKIMIDCWHADPAQRPTFASL 4745
L +S N + E+K +S +IH E++ G+ YL ++ +HRD++A NIL+ ++ VK+ DFG++ G + K++ + PY W APE +V + K+D+WS GI YE+L P P K + + P+ P + P D + C PA RP+ +L
Sbjct: 105 LKRSYVNGLPEEK--VSFIIH---EVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVS----GHIRSTLKRDTFVGTPY-WMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNL---------PKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNL 266 HSP 2 Score: 31.9574 bits (71), Expect = 5.710e-15 Identity = 25/84 (29.76%), Postives = 39/84 (46.43%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKWGRAYEVAA---KMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLK 4240
GRG FG V+KA E+ A L+ + + E QE + +L+ I + E D+ M I++E+ GS + LK
Sbjct: 25 GRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLE--DVSMWIVMEYCGGGSCSDLLK 106
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 78.1814 bits (191), Expect = 6.025e-15 Identity = 43/131 (32.82%), Postives = 76/131 (58.02%), Query Frame = 3
Query: 4263 NLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGL-TEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGY-RMPNPET 4649
N +QM +++ E +G+ +L ++K++HRD+++DNIL+ VK+ DFG E+TE ++ + PY W APE K + K DVWS GI++ E++ P + P K + ++G ++ +PE+
Sbjct: 480 NENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTE--KRSKRATMVGTPY-WMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPES 607
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 78.1814 bits (191), Expect = 7.321e-15 Identity = 46/143 (32.17%), Postives = 72/143 (50.35%), Query Frame = 3
Query: 4305 GMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPT 4733
G+ YL E V+HRD++A NIL++ D TVK+ADFG++ I N L W APE ++ ++ SD+WS G + E+LT NPPY + + Y +T+ P + + + C+ + +RPT
Sbjct: 133 GLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIV-----NSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLT-KNPPYHNLTDANI-------YYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPT 262
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 78.1814 bits (191), Expect = 1.045e-14 Identity = 47/168 (27.98%), Postives = 90/168 (53.57%), Query Frame = 3
Query: 4281 HMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKV-FTSKSDVWSFGIVMYEILT----WSNPPYPDTPAKEVIDKVSSGYRM-------PNPETFIPGVHCPDEIYKIMID-CWHADPAQRPTFASL 4745
H+ ++ +G+AYL S+ ++HRD++ADN+L+ D K++DFG++ ++ N + +R W APE +K +++K D+WS G ++ E+ WSN ++ V++ +++ P PE +P + +I + +D C+ +P +RPT L
Sbjct: 1282 HLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSD-MTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSN-----------LEVVAAMFKIGKSKSAPPIPEDTLPLI---SQIGRNFLDACFEINPEKRPTANEL 1434
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18]) HSP 1 Score: 156.762 bits (395), Expect = 6.999e-53 Identity = 78/189 (41.27%), Postives = 109/189 (57.67%), Query Frame = 3
Query: 4248 KEKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLI-VENASNGFYYSQSK 4811
K K + +++M ++ M+YLES +HRDL A N LV D+ VKVADFGL+ + + + +FP KWTAPEA F+ KSDVW+FGI+++E+ T+ PYP +V DK+ GYRMP PE CP E+Y +M CW DP RP+F + E+L+T+ N + G Y S K
Sbjct: 103 KGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVS-EDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEG------CPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSNVNEGVYISYIK 284 HSP 2 Score: 71.2478 bits (173), Expect = 6.999e-53 Identity = 38/93 (40.86%), Postives = 60/93 (64.52%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKWGRAYE-VAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKKNESFT 4273
G G +G V++ W + + VA K L+ E E+FL+EA +M ++H+ +V+LLGVCT ++ P II EFM G+L +YL+S +GK ++ T
Sbjct: 21 GGGQYGEVYEGTWKKYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCT--REPPFYIITEFMMNGNLLDYLRSPKGKDLDAVT 111
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO46109 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR56]) HSP 1 Score: 111.694 bits (278), Expect = 3.283e-48 Identity = 81/249 (32.53%), Postives = 133/249 (53.41%), Query Frame = -3
Query: 1130 FKFLNSSLYGKSVENLKKRMNLRLCNSFEKMVTYSSKPSFRKCIKIDDDLIAAHLNKELICLDRPSYIGQTVLDLSKLRMYQLQYLELEKYRNLFNCRIDIVAGDTDSFFLEIKNCKLSTLLPAMVSDNLLDTSNYDPSHP--L*S*KLDSLIGKFKDESKGLGYKEWVFLRPKCYS--LLGETESNKAKGITLEGTEIKHLSYLDCYRNDTIFSVPQTR----IGTRNHQLFTFKNSKIALSNNDDKR 1852
FK +N+S++GK++EN++ R+++RL + ++ SKP+++ ++L A H+ K + ++P Y+G +LDLSK MY Y + + + + ++ DTDS EI+ + V ++ DTSNY +HP + S +IG FKDE+ GL E+V LR K YS + G E+ K KG+ + +K D Y++ PQ R I + H ++T +K ALS+ DDKR
Sbjct: 1357 FKLMNNSVFGKTMENIRNRVDIRLITNEKQARKLISKPNYKHRTIFCENLAAIHMRKTRLVFNKPVYLGMCILDLSKNLMYDFHYGYV---KPKYGDKAKLLFTDTDSLMYEIETEDFYKDISGDVR-SMFDTSNYPRNHPSGIESGLNKKIIGMFKDETGGLQITEFVGLRAKLYSYRMDGGGEAKKCKGV--KRAVVKKSIGFDDYKDCLFGKEPQMRMMNVIRSHGHNVYTETVNKRALSHEDDKR 1599 HSP 2 Score: 100.908 bits (250), Expect = 3.283e-48 Identity = 58/145 (40.00%), Postives = 82/145 (56.55%), Query Frame = -1
Query: 1852 NLYGWALSQSLPFGDFSWVINNLDSILDECMSTDIETLSYGY---TMEVDLEIPESVHEFLDKFPVAPEKMCPPDSKVEKLMLTHYPKKNYVIHWRLLKMFVSLGVKVVKIHRAIRFKQAKIFKEYIDTNTSLRADTTNNLDKNI 2277
NLYGWA+S+ LP F W+ TD E +G +EVD+ P +H+ D +P+APE + +KV KL+ K YV+H LK++ SLG+KV K+HR I F+++ K YID NTSLRA TN+ +K+
Sbjct: 1227 NLYGWAMSKPLPTHGFRWM-------------TDQELKEWGRHPCVVEVDMAYPRHLHDSHDDYPLAPESI--KINKVGKLIPNLNDKTKYVVHHETLKLYESLGLKVTKVHRGITFEESGWLKTYIDLNTSLRAKATNDFEKDF 1356
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO49315 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHA0]) HSP 1 Score: 155.221 bits (391), Expect = 2.213e-46 Identity = 73/168 (43.45%), Postives = 107/168 (63.69%), Query Frame = 3
Query: 4266 LSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLI 4769
L ++ +I++GM YL S K +HRDL A NILVADD +K+ADFGL + ++ + R P KW A EA +V+T++SDVWSFGIV++EI+T+ PYP P +++ +++GYRM P V+C E+Y+IM +CW+ +P RPTF SL + D L+
Sbjct: 173 LLNLMTFCYQIAKGMEYLASRKCIHRDLAARNILVADDNILKIADFGLARDVHNVDYYRKTTDGRLPVKWMAFEALFDRVYTTQSDVWSFGIVVWEIITFGGTPYPGVPIEKLCMLLNTGYRMERP------VNCSKELYEIMRNCWNENPEARPTFTSLVQAFDDLV 334 HSP 2 Score: 51.2174 bits (121), Expect = 2.213e-46 Identity = 30/91 (32.97%), Postives = 51/91 (56.04%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKW------GRAYEVAAKMLQSTKAEREKF--LQEAKIMHKL-RHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKS 4243
G G FG V +A+ VA KML+ E+E F + E ++M + +H I+ LLG CT Q P+ ++VE+ ++G+L+++L+
Sbjct: 66 GEGAFGKVMRAEAFGLHGNSACTTVAVKMLKEDATEQELFDLVSEMEVMKSIGKHINIINLLGTCT--QHGPLFVLVEYARWGNLRQFLRD 154
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8]) HSP 1 Score: 153.68 bits (387), Expect = 7.374e-45 Identity = 78/174 (44.83%), Postives = 112/174 (64.37%), Query Frame = 3
Query: 4251 EKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLT-EITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLI 4769
+ K +L Q++ M I+ GM YL VHRDL A NILV + L KVADFGL+ E+ + A E K P +WTAPEA K + F++ SDVWS+GI+++E +++ PY D EV+D+V +GYR+P P + CP I++IM++CW AD +RP+FA + +QLD+LI
Sbjct: 152 DSKLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSRELEDSAYETSGGK---IPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPP------MSCPKVIHQIMLECWDADRTKRPSFALIVKQLDSLI 316 HSP 2 Score: 47.3654 bits (111), Expect = 7.374e-45 Identity = 34/92 (36.96%), Postives = 47/92 (51.09%), Query Frame = 2
Query: 3998 GRGCFGSVHKAKWGRAYE----VAAKMLQ--STKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
G G FG V+K R E VA K L+ ST R FL EA +M + ++ L GV ++ P++I+ EFM GSL +LK + K
Sbjct: 65 GGGEFGDVYKGTLKRPGENTIPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKTH--PLMIVTEFMSNGSLDNFLKKMDSK 154
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO49191 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHA4]) HSP 1 Score: 155.606 bits (392), Expect = 1.423e-44 Identity = 68/170 (40.00%), Postives = 109/170 (64.12%), Query Frame = 3
Query: 4251 EKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
+K L ++ +++ GM YLES+K +HRDL A N+LV+D+ +K+ADFGL + ++ + R P KW A EA +V+T++SDVW++GI+M+EI+T+ PYP P ++ + + GYRM P V+C D++Y +M+ CWH +P QRPTFA + +++D
Sbjct: 434 REKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLARDIHDIDYYRKTTDGRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPLWKLFELLKEGYRMEQP------VNCQDDVYALMLRCWHENPNQRPTFAEIVKEMD 597 HSP 2 Score: 44.669 bits (104), Expect = 1.423e-44 Identity = 29/91 (31.87%), Postives = 47/91 (51.65%), Query Frame = 2
Query: 3998 GRGCFGSVHKA------KWGRAYEVAAKMLQSTKAERE--KFLQEAKIMHKL-RHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKS 4243
G G FG V KA VA KML+ E E + E ++M + +H I+ L+G CT Q P+ ++VE+ G+L+++L++
Sbjct: 330 GEGAFGRVVKADAIGLPNMPYRCNVAVKMLKEDATEHELADLVSEMEVMKTIGQHVNIINLIGACT--QKGPLFVVVEYASQGNLRQFLRA 418
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:NCBI gene;Acc:101173856]) HSP 1 Score: 171.785 bits (434), Expect = 8.110e-68 Identity = 83/169 (49.11%), Postives = 107/169 (63.31%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M A+I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFG+++ E+ T PYP +EV+D+V GYRMP P CP ++++M+ CW DP +RPTF LQ L+
Sbjct: 367 KLLRLPQLVDMAAQIAAGMAYVEKMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCP------AECPSSLHELMLSCWRKDPEERPTFEYLQGFLE 528 HSP 2 Score: 79.7221 bits (195), Expect = 8.110e-68 Identity = 59/173 (34.10%), Postives = 85/173 (49.13%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP-----------DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ Y K+ G H LTD P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 210 VKHYKIRK--LDSGGFYITSRTQFTSLQQLVFHYRKHSDGLCHA-LTDVCPVAKPQTQGLARDAWEIP---------RESLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSQGSLLDFLKGDTGK 367 HSP 3 Score: 49.6766 bits (117), Expect = 8.110e-68 Identity = 27/108 (25.00%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D++F + + ++ + W + G +P+NYV+ D + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 99 ALYDYESRTASDLTFRKGDRLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQAEEWYFGKITRRDSERLLLNLQNRRGTFLVRESETTKGAYCLSVLDYDNAK 206
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: blk (BLK proto-oncogene, Src family tyrosine kinase [Source:NCBI gene;Acc:101163706]) HSP 1 Score: 158.303 bits (399), Expect = 3.727e-65 Identity = 78/160 (48.75%), Postives = 101/160 (63.12%), Query Frame = 3
Query: 4257 KTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTF 4736
K ++++I M A+I+EGMAY+E + +HRDLRA NILV++ L K+ADFGL I E QE +FP KWTAPEA FT KSDVWSFGI++ EI+T+ PYP EV+ + YRMP P+ CP E+Y IM+ CW P +RPTF
Sbjct: 314 KLKMNKLIDMSAQIAEGMAYIEKKNYIHRDLRAANILVSETLHCKIADFGLARIIETEYTAQE--GAKFPIKWTAPEAINFGTFTIKSDVWSFGILLTEIVTYGRIPYPGMTNPEVVRCLDQSYRMPRPD------DCPVELYDIMMMCWRQRPEERPTF 465 HSP 2 Score: 75.0998 bits (183), Expect = 3.727e-65 Identity = 54/164 (32.93%), Postives = 87/164 (53.05%), Query Frame = 2
Query: 3767 LVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK 4258
+VKH++I+ DK Y F + L+++Y + G + P + Q P + EI R+ +++ ++G G FG V + +VA K L+ E E FLQEA +M +L+H ++V L V T+ P++I+ E+M GSL ++LKSDEG K
Sbjct: 156 VVKHYKIRC--LDKGGFYISPSTTFSSLSELVKYYSRTADGLCERLNSPCKPKDPQEPWAHDEWEIPRDTLKMTKKLGAGQFGEVWMGYYKNTQKVAIKTLKEGTMEPEAFLQEANLMKQLQHDRLVRLHAVVTKE---PILIVTEYMVNGSLLDFLKSDEGGK 314 HSP 3 Score: 58.151 bits (139), Expect = 3.727e-65 Identity = 34/114 (29.82%), Postives = 68/114 (59.65%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAW--REIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKKKNFL 3768
A++ + AT +D+SF+ + + +L E W + ++ +G +P+NYV++ D VE W +++ R E E+LL+ G + GT++IR S + ++LS+RD D+++ + +
Sbjct: 47 AQHDFKATNGSDLSFKKGDKLKILHERGE-WCLAKSISTGDEGYIPSNYVARADS--LEVEKWFFKDVSRRETERLLLAPGNKPGTFLIRESETSKGSYSLSIRDHDQQQGDVV 157
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: yrk (proto-oncogene tyrosine-protein kinase Yrk [Source:NCBI gene;Acc:101155365]) HSP 1 Score: 160.999 bits (406), Expect = 4.109e-65 Identity = 79/165 (47.88%), Postives = 107/165 (64.85%), Query Frame = 3
Query: 4266 LSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
L Q++ M A+I+ GMAY+E +HRDLRA NILV D+L K+ADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E++T PYP +EV+++V GYRMP PG CP ++++M+ CW +P +R TF LQ L+
Sbjct: 353 LPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMP----CAPG--CPASLHELMLQCWRREPDERHTFEYLQSFLE 510 HSP 2 Score: 75.8702 bits (185), Expect = 4.109e-65 Identity = 60/173 (34.68%), Postives = 88/173 (50.87%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRG-FPDILTLIQFYEKNGIGNSH---------VPLTDPLP-DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ + N Y I R F + L++ Y + G + VPLT L D ++ P RE + + ++G+GCFG V W +VA K L+ E FL+EA+IM +LRH K+V+L V +E P+ II EFM GSL ++LK EG+
Sbjct: 192 VKHYKIR---KLDNGGYYITTRSQFDTVQQLVEHYTGSNDGLCYYLTKSCPNSVPLTMGLARDAWEVP---------RETLTLQKKLGQGCFGDVCMGMWNGTTKVAVKTLKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVSEE---PIYIITEFMSEGSLLDFLKDGEGQ 349 HSP 3 Score: 55.0694 bits (131), Expect = 4.109e-65 Identity = 32/118 (27.12%), Postives = 61/118 (51.69%), Query Frame = 1
Query: 3418 GSYMVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKKKNFL 3768
G + A Y Y A E D++F+ E ++ + W ++ G +P+NYV+ D + ++ R +AE+ L+ G +GT++IR S + ++LS+RD+D+ K + +
Sbjct: 75 GVTLFIALYDYDARTEDDLTFQKGEKFQIINNTEGDWWEARSLDTGKSGYIPSNYVAPIDSIQAEEWYFGKMGRKDAERQLLGQGNPRGTFLIRESETTKGAYSLSIRDWDDTKGDHV 192
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: src (proto-oncogene tyrosine-protein kinase Src [Source:NCBI gene;Acc:101164480]) HSP 1 Score: 167.162 bits (422), Expect = 4.609e-65 Identity = 81/169 (47.93%), Postives = 107/169 (63.31%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++++M+ CW + +RPTF LQ L+
Sbjct: 368 KMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELATKGRVPYPGMVNREVLDQVDRGYRMPCP------ADCPESLHELMLTCWRKEAEERPTFEYLQSFLE 529 HSP 2 Score: 79.7221 bits (195), Expect = 4.609e-65 Identity = 59/173 (34.10%), Postives = 85/173 (49.13%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP-----------DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ Y K+ G H LTD P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 211 VKHYKIRK--LDSGGFYITSRTQFSGLQPLVNHYRKHADGLCH-SLTDICPVLKPQTQGLAKDAWEIP---------RESLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSQGSLLDFLKGDMGK 368 HSP 3 Score: 45.0542 bits (105), Expect = 4.609e-65 Identity = 30/121 (24.79%), Postives = 59/121 (48.76%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEA-------------WREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + ++ + W + G +P+NYV+ +S++A + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 91 ALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLATGESGYIPSNYVAPS----ESIQAEDDLKLTLDSRWYFGKITRRDSERLLLSLENRRGTFLVRESETTKGAYCLSVLDYDNTK 207
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: src (proto-oncogene tyrosine-protein kinase Src [Source:NCBI gene;Acc:101164480]) HSP 1 Score: 167.162 bits (422), Expect = 9.369e-65 Identity = 81/169 (47.93%), Postives = 107/169 (63.31%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLD 4760
K L Q++ M ++I+ GMAY+E VHRDLRA NILV D+L KVADFGL + E NE ++ +FP KWTAPEAA FT KSDVWSFGI++ E+ T PYP +EV+D+V GYRMP P CP+ ++++M+ CW + +RPTF LQ L+
Sbjct: 365 KMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELATKGRVPYPGMVNREVLDQVDRGYRMPCP------ADCPESLHELMLTCWRKEAEERPTFEYLQSFLE 526 HSP 2 Score: 79.7221 bits (195), Expect = 9.369e-65 Identity = 59/173 (34.10%), Postives = 85/173 (49.13%), Query Frame = 2
Query: 3770 VKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLP-----------DNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGK 4255
VKH++I+ D Y + F + L+ Y K+ G H LTD P D ++ P RE++ + ++G+GCFG V W VA K L+ E FLQEA++M KLRH K+V+L V +E P+ I+ E+M GSL ++LK D GK
Sbjct: 208 VKHYKIRK--LDSGGFYITSRTQFSGLQPLVNHYRKHADGLCH-SLTDICPVLKPQTQGLAKDAWEIP---------RESLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSQGSLLDFLKGDMGK 365 HSP 3 Score: 43.8986 bits (102), Expect = 9.369e-65 Identity = 30/115 (26.09%), Postives = 57/115 (49.57%), Query Frame = 1
Query: 3436 AKYKYTATAETDISFEDKEVMFVLEVF-------DEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSR-KENCFALSVRDFDEKK 3756
A Y Y + +D+SF E + ++ + WL L + G +P+NYV+ + + +I R ++E+LL+ + ++GT+++R S + + LSV D+D K
Sbjct: 91 ALYDYESRTASDLSFRKGERLQIVNNTRKVNCREGDWWLARSLATGE-SGYIPSNYVAPSESIQAEEWYFGKITRRDSERLLLSLENRRGTFLVRESETTKGAYCLSVLDYDNTK 204
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000072548.1 (SMESG000072548.1) HSP 1 Score: 394.045 bits (1011), Expect = 0.000e+0 Identity = 186/186 (100.00%), Postives = 186/186 (100.00%), Query Frame = 3
Query: 4254 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQSK 4811
KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQSK
Sbjct: 310 KKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVADFGLTEITEGANENQEKKNLRFPYKWTAPEAAKSKVFTSKSDVWSFGIVMYEILTWSNPPYPDTPAKEVIDKVSSGYRMPNPETFIPGVHCPDEIYKIMIDCWHADPAQRPTFASLQEQLDTLIVENASNGFYYSQSK 495 HSP 2 Score: 319.701 bits (818), Expect = 0.000e+0 Identity = 168/171 (98.25%), Postives = 170/171 (99.42%), Query Frame = 2
Query: 3749 KRKKIFLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDXXXXXXXXXXXXXXGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKKN 4261
++KKIFLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDIEINRENIEILNEIGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKK
Sbjct: 142 EKKKIFLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSHVPLTDPLPDNYQPPIHFQDIEINRENIEILNEIGRGCFGSVHKAKWGRAYEVAAKMLQSTKAEREKFLQEAKIMHKLRHRKIVELLGVCTEPQDMPMIIIVEFMKFGSLKEYLKSDEGKKT 312 HSP 3 Score: 277.33 bits (708), Expect = 3.248e-81 Identity = 153/167 (91.62%), Postives = 156/167 (93.41%), Query Frame = 1
Query: 3325 MGQKGXXXXXXXXXXXXXVIQTVGKAYEGPPGSYMVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKNFLGKAFSNKSQYRG*KHTLFN 3825
MGQKGSKSKTLSKKSLKTVIQTVGKAYEGPPGSYMVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKK FL K F K K+TL++
Sbjct: 1 MGQKGSKSKTLSKKSLKTVIQTVGKAYEGPPGSYMVKAKYKYTATAETDISFEDKEVMFVLEVFDEHWLRVELKNSKLQGLVPANYVSKQDGSPQSVEAWREIQRWEAEKLLMRVGLQKGTYIIRPSRKENCFALSVRDFDEKKKIFLVKHFQIKVNIED-KNTLYS 166
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000053372.1 (SMESG000053372.1) HSP 1 Score: 429.869 bits (1104), Expect = 2.089e-177 Identity = 204/263 (77.57%), Postives = 234/263 (88.97%), Query Frame = -3
Query: 1064 FKFLNSSLYGKSVENLKKRMNLRLCNSFEKMVTYSSKPSFRKCIKIDDDLIAAHLNKELICLDRPSYIGQTVLDLSKLRMYQLQYLELEKYRNLFNCRIDIVAGDTDSFFLEIKNCKLSTLLPAMVSDNLLDTSNYDPSHPL*S*KLDSLIGKFKDESKGLGYKEWVFLRPKCYSLLGETESNKAKGITLEGTEIKHLSYLDCYRNDTIFSVPQTRIGTRNHQLFTFKNSKIALSNNDDKRQWVGKNKSFAFGHYLGINATDV 1852
FK N+SLYGKSVENLKKRMNLRLCNS EK++TYSSKP+FRK I+I DDL AAHLNK+ ICLDRPSYIGQ+VLDLSKLRMYQLQY+EL+KYR+++NC I++VAGDTDSFFLEIKN KL LL AM+SD+LLDTSNYDPSHPL S +LDS+IGKFKDESKGLGY EWVFLRPKCYSLLG + +AKG+ L GT+IKH SYL+CY N++I SVPQTRIGTRNHQLFTFKNSKIAL+N+DDKR WVGKN SFA+GHY G++ DV
Sbjct: 1533 FKLYNNSLYGKSVENLKKRMNLRLCNSAEKLITYSSKPAFRKTIEITDDLFAAHLNKDSICLDRPSYIGQSVLDLSKLRMYQLQYVELQKYRDIYNCDINLVAGDTDSFFLEIKNLKLEILLKAMISDDLLDTSNYDPSHPLYSRRLDSVIGKFKDESKGLGYSEWVFLRPKCYSLLGNKSTMRAKGVKLPGTDIKHQSYLNCYNNNSIMSVPQTRIGTRNHQLFTFKNSKIALNNHDDKRAWVGKNSSFAYGHYRGVDVLDV 1795 HSP 2 Score: 214.542 bits (545), Expect = 2.089e-177 Identity = 94/143 (65.73%), Postives = 121/143 (84.62%), Query Frame = -1
Query: 1852 NLYGWALSQSLPFGDFSWVINNLDSILDECMST-DIETLSYGYTMEVDLEIPESVHEFLDKFPVAPEKMCPPDSKVEKLMLTHYPKKNYVIHWRLLKMFVSLGVKVVKIHRAIRFKQAKIFKEYIDTNTSLRADTTNNLDKNI 2277
NLYGWALSQSLP+ DF+WV + LD +L+EC + DIE L YGYTMEVD+EIP+++H+FL+ FP+ PEKMCPP+SKVEKLMLTHYPKKNYV+HWRLL++++SLG KV IHRAI++KQA FK YID NT+LRA+ + L +++
Sbjct: 1390 NLYGWALSQSLPYADFTWVYDGLDEVLNECANVVDIEILPYGYTMEVDIEIPDNLHDFLNDFPIGPEKMCPPNSKVEKLMLTHYPKKNYVLHWRLLRLYLSLGAKVTHIHRAIKYKQAPTFKHYIDKNTNLRANAVSELYRDL 1532
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000066165.1 (SMESG000066165.1) HSP 1 Score: 433.721 bits (1114), Expect = 6.635e-177 Identity = 204/260 (78.46%), Postives = 233/260 (89.62%), Query Frame = -3
Query: 1073 FKFLNSSLYGKSVENLKKRMNLRLCNSFEKMVTYSSKPSFRKCIKIDDDLIAAHLNKELICLDRPSYIGQTVLDLSKLRMYQLQYLELEKYRNLFNCRIDIVAGDTDSFFLEIKNCKLSTLLPAMVSDNLLDTSNYDPSHPL*S*KLDSLIGKFKDESKGLGYKEWVFLRPKCYSLLGETESNKAKGITLEGTEIKHLSYLDCYRNDTIFSVPQTRIGTRNHQLFTFKNSKIALSNNDDKRQWVGKNKSFAFGHYLGINA 1852
+K N+SLYGKSVENLKKRMNLRLCNS EKM+ Y+SKP+F+K IKI DDLIAAHLNK+ ICLDRPSYIGQ+VLDLSKLRMYQLQY EL KYR+ FNC I+IVAGDTDSFFLE+K+CKL LLPAM+ DNLLDTSNYDP+HPL S KLDS+IGKFKDESKGLGYKEWVFLRPKCYSLLG++++ +AKG+ L GT+IKH SYLDCY + +F+VPQ+RIGTRNHQL+TFKNSKIALSNNDDKR WVGKN S AFGHY G++A
Sbjct: 818 YKLFNNSLYGKSVENLKKRMNLRLCNSAEKMIVYASKPTFKKSIKIVDDLIAAHLNKDSICLDRPSYIGQSVLDLSKLRMYQLQYNELAKYRSEFNCDINIVAGDTDSFFLEVKHCKLDILLPAMIRDNLLDTSNYDPAHPLYSRKLDSVIGKFKDESKGLGYKEWVFLRPKCYSLLGKSDTMRAKGVKLLGTDIKHQSYLDCYNKNVVFTVPQSRIGTRNHQLYTFKNSKIALSNNDDKRLWVGKNTSIAFGHYFGVDA 1077 HSP 2 Score: 209.534 bits (532), Expect = 6.635e-177 Identity = 92/142 (64.79%), Postives = 119/142 (83.80%), Query Frame = -1
Query: 1852 NLYGWALSQSLPFGDFSWVINNLDSILDECMSTDIETLSYGYTMEVDLEIPESVHEFLDKFPVAPEKMCPPDSKVEKLMLTHYPKKNYVIHWRLLKMFVSLGVKVVKIHRAIRFKQAKIFKEYIDTNTSLRADTTNNLDKNI 2277
NLYGWALSQ+LP+GDF WV +NL+ +L EC++ +IE L YGYTMEVD+ IPE VH++L+ FP+APEKMCPP+SKVEKLMLTHY KKN+V+HWRLLK+++ LG +V IHRAI+FKQ+ IFKEYI NT LR++T L +++
Sbjct: 676 NLYGWALSQNLPYGDFVWVHDNLNDVLSECVNANIEFLPYGYTMEVDINIPERVHQYLNDFPLAPEKMCPPNSKVEKLMLTHYSKKNHVLHWRLLKLYIELGAEVECIHRAIKFKQSPIFKEYIQRNTDLRSNTKCELYRDL 817
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000066165.1 (SMESG000066165.1) HSP 1 Score: 433.721 bits (1114), Expect = 6.860e-177 Identity = 204/260 (78.46%), Postives = 233/260 (89.62%), Query Frame = -3
Query: 1073 FKFLNSSLYGKSVENLKKRMNLRLCNSFEKMVTYSSKPSFRKCIKIDDDLIAAHLNKELICLDRPSYIGQTVLDLSKLRMYQLQYLELEKYRNLFNCRIDIVAGDTDSFFLEIKNCKLSTLLPAMVSDNLLDTSNYDPSHPL*S*KLDSLIGKFKDESKGLGYKEWVFLRPKCYSLLGETESNKAKGITLEGTEIKHLSYLDCYRNDTIFSVPQTRIGTRNHQLFTFKNSKIALSNNDDKRQWVGKNKSFAFGHYLGINA 1852
+K N+SLYGKSVENLKKRMNLRLCNS EKM+ Y+SKP+F+K IKI DDLIAAHLNK+ ICLDRPSYIGQ+VLDLSKLRMYQLQY EL KYR+ FNC I+IVAGDTDSFFLE+K+CKL LLPAM+ DNLLDTSNYDP+HPL S KLDS+IGKFKDESKGLGYKEWVFLRPKCYSLLG++++ +AKG+ L GT+IKH SYLDCY + +F+VPQ+RIGTRNHQL+TFKNSKIALSNNDDKR WVGKN S AFGHY G++A
Sbjct: 842 YKLFNNSLYGKSVENLKKRMNLRLCNSAEKMIVYASKPTFKKSIKIVDDLIAAHLNKDSICLDRPSYIGQSVLDLSKLRMYQLQYNELAKYRSEFNCDINIVAGDTDSFFLEVKHCKLDILLPAMIRDNLLDTSNYDPAHPLYSRKLDSVIGKFKDESKGLGYKEWVFLRPKCYSLLGKSDTMRAKGVKLLGTDIKHQSYLDCYNKNVVFTVPQSRIGTRNHQLYTFKNSKIALSNNDDKRLWVGKNTSIAFGHYFGVDA 1101 HSP 2 Score: 209.534 bits (532), Expect = 6.860e-177 Identity = 92/142 (64.79%), Postives = 119/142 (83.80%), Query Frame = -1
Query: 1852 NLYGWALSQSLPFGDFSWVINNLDSILDECMSTDIETLSYGYTMEVDLEIPESVHEFLDKFPVAPEKMCPPDSKVEKLMLTHYPKKNYVIHWRLLKMFVSLGVKVVKIHRAIRFKQAKIFKEYIDTNTSLRADTTNNLDKNI 2277
NLYGWALSQ+LP+GDF WV +NL+ +L EC++ +IE L YGYTMEVD+ IPE VH++L+ FP+APEKMCPP+SKVEKLMLTHY KKN+V+HWRLLK+++ LG +V IHRAI+FKQ+ IFKEYI NT LR++T L +++
Sbjct: 700 NLYGWALSQNLPYGDFVWVHDNLNDVLSECVNANIEFLPYGYTMEVDINIPERVHQYLNDFPLAPEKMCPPNSKVEKLMLTHYSKKNHVLHWRLLKLYIELGAEVECIHRAIKFKQSPIFKEYIQRNTDLRSNTKCELYRDL 841
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000066165.1 (SMESG000066165.1) HSP 1 Score: 433.335 bits (1113), Expect = 8.035e-177 Identity = 204/260 (78.46%), Postives = 233/260 (89.62%), Query Frame = -3
Query: 1073 FKFLNSSLYGKSVENLKKRMNLRLCNSFEKMVTYSSKPSFRKCIKIDDDLIAAHLNKELICLDRPSYIGQTVLDLSKLRMYQLQYLELEKYRNLFNCRIDIVAGDTDSFFLEIKNCKLSTLLPAMVSDNLLDTSNYDPSHPL*S*KLDSLIGKFKDESKGLGYKEWVFLRPKCYSLLGETESNKAKGITLEGTEIKHLSYLDCYRNDTIFSVPQTRIGTRNHQLFTFKNSKIALSNNDDKRQWVGKNKSFAFGHYLGINA 1852
+K N+SLYGKSVENLKKRMNLRLCNS EKM+ Y+SKP+F+K IKI DDLIAAHLNK+ ICLDRPSYIGQ+VLDLSKLRMYQLQY EL KYR+ FNC I+IVAGDTDSFFLE+K+CKL LLPAM+ DNLLDTSNYDP+HPL S KLDS+IGKFKDESKGLGYKEWVFLRPKCYSLLG++++ +AKG+ L GT+IKH SYLDCY + +F+VPQ+RIGTRNHQL+TFKNSKIALSNNDDKR WVGKN S AFGHY G++A
Sbjct: 880 YKLFNNSLYGKSVENLKKRMNLRLCNSAEKMIVYASKPTFKKSIKIVDDLIAAHLNKDSICLDRPSYIGQSVLDLSKLRMYQLQYNELAKYRSEFNCDINIVAGDTDSFFLEVKHCKLDILLPAMIRDNLLDTSNYDPAHPLYSRKLDSVIGKFKDESKGLGYKEWVFLRPKCYSLLGKSDTMRAKGVKLLGTDIKHQSYLDCYNKNVVFTVPQSRIGTRNHQLYTFKNSKIALSNNDDKRLWVGKNTSIAFGHYFGVDA 1139 HSP 2 Score: 209.534 bits (532), Expect = 8.035e-177 Identity = 92/142 (64.79%), Postives = 119/142 (83.80%), Query Frame = -1
Query: 1852 NLYGWALSQSLPFGDFSWVINNLDSILDECMSTDIETLSYGYTMEVDLEIPESVHEFLDKFPVAPEKMCPPDSKVEKLMLTHYPKKNYVIHWRLLKMFVSLGVKVVKIHRAIRFKQAKIFKEYIDTNTSLRADTTNNLDKNI 2277
NLYGWALSQ+LP+GDF WV +NL+ +L EC++ +IE L YGYTMEVD+ IPE VH++L+ FP+APEKMCPP+SKVEKLMLTHY KKN+V+HWRLLK+++ LG +V IHRAI+FKQ+ IFKEYI NT LR++T L +++
Sbjct: 738 NLYGWALSQNLPYGDFVWVHDNLNDVLSECVNANIEFLPYGYTMEVDINIPERVHQYLNDFPLAPEKMCPPNSKVEKLMLTHYSKKNHVLHWRLLKLYIELGAEVECIHRAIKFKQSPIFKEYIQRNTDLRSNTKCELYRDL 879 The following BLAST results are available for this feature:
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tyrosine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30003251 ID=SMED30003251|Name=Tyrosine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=4908bpback to top protein sequence of SMED30003251-orf-1 >SMED30003251-orf-1 ID=SMED30003251-orf-1|Name=SMED30003251-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=151bp MQGLFSNKSVMVNNQNETTKNTRTRKDVNLKPVHIYLGHRMYLVNEIEYKback to top protein sequence of SMED30003251-orf-2 >SMED30003251-orf-2 ID=SMED30003251-orf-2|Name=SMED30003251-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=124bp MNLRLCNSFEKMVTYSSKPSFRKCIKIDDDLIAAHLNKELICLDRPSYIGback to top protein sequence of SMED30003251-orf-3 >SMED30003251-orf-3 ID=SMED30003251-orf-3|Name=SMED30003251-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=190bp MKEKKTNLSQMIHMMAEISEGMAYLESEKVVHRDLRADNILVADDLTVKVback to top protein sequence of SMED30003251-orf-4 >SMED30003251-orf-4 ID=SMED30003251-orf-4|Name=SMED30003251-orf-4|organism=Schmidtea mediterranea sexual|type=polypeptide|length=116bp MSTDIETLSYGYTMEVDLEIPESVHEFLDKFPVAPEKMCPPDSKVEKLMLback to top protein sequence of SMED30003251-orf-5 >SMED30003251-orf-5 ID=SMED30003251-orf-5|Name=SMED30003251-orf-5|organism=Schmidtea mediterranea sexual|type=polypeptide|length=183bp MKRKKIFLVKHFQIKVNIEDKNTLYSINVRGFPDILTLIQFYEKNGIGNSback to top protein sequence of SMED30003251-orf-6 >SMED30003251-orf-6 ID=SMED30003251-orf-6|Name=SMED30003251-orf-6|organism=Schmidtea mediterranea sexual|type=polypeptide|length=161bp MGQKGSKSKTLSKKSLKTVIQTVGKAYEGPPGSYMVKAKYKYTATAETDIback to top Annotated Terms
The following terms have been associated with this transcript:
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