Pleckstrin homology domain-containing family F member 2

Overview


Name	Pleckstrin homology domain-containing family F member 2
Smed ID	SMED30003223
Length (bp)	1007

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Pleckstrin homology domain-containing family F member 2 (SMED30003223) t-SNE clustered cells

Violin plots show distribution of expression levels for Pleckstrin homology domain-containing family F member 2 (SMED30003223) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Pleckstrin homology domain-containing family F member 2 (SMED30003223) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30003223

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30003223	SMESG000070592.1	Contig2705	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30003223	SMESG000038764.1	Contig2705	GPL15192	PMID:23079596 Forsthoefel et al., 2012
epidermis	SMED30003223	SMESG000038764.1	dd_Smed_v4_6176_1_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Human
Match: PLEKHF2 (pleckstrin homology and FYVE domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20757])

HSP 1 Score: 221.476 bits (563), Expect = 1.263e-70
Identity = 107/209 (51.20%), Postives = 138/209 (66.03%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++  RI  +EN FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS  PVR+CD CY+ L  G+
Sbjct:    8 SEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGD 215

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Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++  RI  +EN FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS  PVR+CD CY+ L  G+
Sbjct:    8 SEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGD 215

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Human
Match: PLEKHF1 (pleckstrin homology and FYVE domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20764])

HSP 1 Score: 193.741 bits (491), Expect = 1.895e-59
Identity = 96/202 (47.52%), Postives = 132/202 (65.35%), Query Frame = 1

Query:  103 SDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            + +RI  +E+ FG SG PL+   R L+GEG+L K CRKK K R FFLF+DILVYGSIV++ +K   QHII +EEV +  L + +     + +K+ KKSF + A SA E+++W++H+++C+    +  G    +   +P WIPD     CM C  T F+ L RRHHCR CG VVC+ CS +R+LLP  SP PVRVC LCY +L
Sbjct:   11 NSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELLPETLQAKNRWMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAP-WIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYREL 211

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Query:  103 SDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            + +RI  +E+ FG SG PL+   R L+GEG+L K CRKK K R FFLF+DILVYGSIV++ +K   QHII +EEV +  L + +     + +K+ KKSF + A SA E+++W++H+++C+    +  G    +   +P WIPD     CM C  T F+ L RRHHCR CG VVC+ CS +R+LLP  SP PVRVC LCY +L
Sbjct:   11 NSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELLPETLQAKNRWMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAP-WIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYREL 211

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Human
Match: PLEKHF1 (pleckstrin homology and FYVE domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20764])

HSP 1 Score: 112.849 bits (281), Expect = 3.857e-30
Identity = 55/118 (46.61%), Postives = 82/118 (69.49%), Query Frame = 1

Query:  103 SDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQK 456
            + +RI  +E+ FG SG PL+   R L+GEG+L K CRKK K R FFLF+DILVYGSIV++ +K   QHII +EEV +  L + +     + +K+ KKSF + A SA E+++W++H+++
Sbjct:   11 NSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELLPETLQAKNRWMIKTAKKSFVVSAASATERQEWISHIEE 128

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Celegans
Match: ZK632.12 (pep chromosome:WBcel235:III:9830802:9832378:1 gene:WBGene00014019.1 transcript:ZK632.12.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK632.12)

HSP 1 Score: 202.601 bits (514), Expect = 2.237e-63
Identity = 95/205 (46.34%), Postives = 134/205 (65.37%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S  +  R+  +E  FG  G  LS   R L+GEG+L+KMCRKKPK+R FFLF+DILVYG+IV+  K+   Q I+ +E V++ DL DD I  +G+ +K+P KSFA+YA +  EK +WM H+++C+ +   +RG    +   + VW+PD  A KCMVC  T F ++ RRHHCR+CG VVC  CS + + +      PVRVCD C++ L
Sbjct:    8 SEVNSRRMANVEQCFGKMGEQLSVFGRVLVGEGVLVKMCRKKPKQRQFFLFNDILVYGNIVISKKRYNKQRILRLEGVQVEDLEDDGIEKHGWIIKTPAKSFAVYAATETEKREWMLHIERCVTDLL-ERGNKQAATAHAAVWVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKKPVRVCDHCFDSL 211

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Celegans
Match: ZK632.12 (pep chromosome:WBcel235:III:9830792:9832430:1 gene:WBGene00014019.1 transcript:ZK632.12.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK632.12)

HSP 1 Score: 202.601 bits (514), Expect = 2.237e-63
Identity = 95/205 (46.34%), Postives = 134/205 (65.37%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S  +  R+  +E  FG  G  LS   R L+GEG+L+KMCRKKPK+R FFLF+DILVYG+IV+  K+   Q I+ +E V++ DL DD I  +G+ +K+P KSFA+YA +  EK +WM H+++C+ +   +RG    +   + VW+PD  A KCMVC  T F ++ RRHHCR+CG VVC  CS + + +      PVRVCD C++ L
Sbjct:    8 SEVNSRRMANVEQCFGKMGEQLSVFGRVLVGEGVLVKMCRKKPKQRQFFLFNDILVYGNIVISKKRYNKQRILRLEGVQVEDLEDDGIEKHGWIIKTPAKSFAVYAATETEKREWMLHIERCVTDLL-ERGNKQAATAHAAVWVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKKPVRVCDHCFDSL 211

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Celegans
Match: aka-1 (A Kinase Anchor protein [Source:UniProtKB/TrEMBL;Acc:H2KZI9])

HSP 1 Score: 68.9366 bits (167), Expect = 1.539e-12
Identity = 31/71 (43.66%), Postives = 40/71 (56.34%), Query Frame = 1

Query:  511 SPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPY-----QSPVPVRVCDLCYEQL 708
            SP WIPD+  P CM+C  T F ++ RRHHCR CG V+C +C  ++  L Y     +    VRVC  C   L
Sbjct:  535 SPYWIPDSECPNCMLCN-TRFTIITRRHHCRACGRVLCGSCCNEKAFLEYLQEEGKKLQAVRVCKPCSAML 604

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Query:  511 SPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPY-----QSPVPVRVCDLCYEQL 708
            SP WIPD+  P CM+C  T F ++ RRHHCR CG V+C +C  ++  L Y     +    VRVC  C   L
Sbjct:  535 SPYWIPDSECPNCMLCN-TRFTIITRRHHCRACGRVLCGSCCNEKAFLEYLQEEGKKLQAVRVCKPCSAML 604

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Celegans
Match: aka-1 (A Kinase Anchor protein [Source:UniProtKB/TrEMBL;Acc:H2KZI9])

HSP 1 Score: 63.5438 bits (153), Expect = 6.498e-11
Identity = 25/50 (50.00%), Postives = 33/50 (66.00%), Query Frame = 1

Query:  511 SPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPY 660
            SP WIPD+  P CM+C  T F ++ RRHHCR CG V+C +C  ++  L Y
Sbjct:  535 SPYWIPDSECPNCMLCN-TRFTIITRRHHCRACGRVLCGSCCNEKAFLEY 583

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
Match: rush (gene:FBgn0025381 transcript:FBtr0070259)

HSP 1 Score: 218.394 bits (555), Expect = 8.792e-69
Identity = 98/206 (47.57%), Postives = 141/206 (68.45%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            S ++  RI  +EN FG SG+PL+   R L+GEG+L KMCRK+PK R FFLF+DILVYG+IV+  KK   QHI+ +EEV +  ++D+     G+ +++  KSF ++A ++ EK++WM H+ KC+++  +K G   +    + VW+PD  A  CM C+ T F  + RRHHCR+CG VVC+ CS K++LLP QS   +RVCD CYE+LK
Sbjct:    8 SEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRKSGKKPVE-NHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLK 212

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
Match: rush (gene:FBgn0025381 transcript:FBtr0339589)

HSP 1 Score: 218.394 bits (555), Expect = 8.792e-69
Identity = 98/206 (47.57%), Postives = 141/206 (68.45%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            S ++  RI  +EN FG SG+PL+   R L+GEG+L KMCRK+PK R FFLF+DILVYG+IV+  KK   QHI+ +EEV +  ++D+     G+ +++  KSF ++A ++ EK++WM H+ KC+++  +K G   +    + VW+PD  A  CM C+ T F  + RRHHCR+CG VVC+ CS K++LLP QS   +RVCD CYE+LK
Sbjct:    8 SEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRKSGKKPVE-NHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLK 212

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
Match: Sara (gene:FBgn0026369 transcript:FBtr0071641)

HSP 1 Score: 71.2478 bits (173), Expect = 3.024e-13
Identity = 28/62 (45.16%), Postives = 40/62 (64.52%), Query Frame = 1

Query:  514 PVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCY 699
            P+W+PD +A +CM C+   F ++ RRHHCR CG V+CS C  +R+ L + +    RVC  CY
Sbjct:  526 PIWVPDNMAGQCMQCQQK-FTMIKRRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCY 586

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
Match: CG6051 (gene:FBgn0039492 transcript:FBtr0339264)

HSP 1 Score: 70.8626 bits (172), Expect = 4.807e-13
Identity = 38/81 (46.91%), Postives = 42/81 (51.85%), Query Frame = 1

Query:  463 DECSKKRGLVGLSATKSP-VWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLP-YQSPVPVRVCDLCY 699
            +E          SAT SP  WIPD  AP+CM C+ T F    RRHHCR+CG V C  CS     LP Y     VRVC  CY
Sbjct:  885 NETQMPSSATSTSATLSPPAWIPDGKAPRCMACQ-TPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCY 964

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
Match: CG6051 (gene:FBgn0039492 transcript:FBtr0305050)

HSP 1 Score: 70.8626 bits (172), Expect = 4.896e-13
Identity = 38/81 (46.91%), Postives = 42/81 (51.85%), Query Frame = 1

Query:  463 DECSKKRGLVGLSATKSP-VWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLP-YQSPVPVRVCDLCY 699
            +E          SAT SP  WIPD  AP+CM C+ T F    RRHHCR+CG V C  CS     LP Y     VRVC  CY
Sbjct:  886 NETQMPSSATSTSATLSPPAWIPDGKAPRCMACQ-TPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCY 965

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Zebrafish
Match: plekhf2 (pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Source:NCBI gene;Acc:393214])

HSP 1 Score: 214.157 bits (544), Expect = 6.143e-68
Identity = 105/215 (48.84%), Postives = 142/215 (66.05%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPR 738
            S ++ +RI  +E  FG +G PL+   R LIGEG+L K+CRK+PK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WM+H+ KC+ +  +K G    +   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS K++LLP QS  PVRVC+ CY+QL  G   + PR
Sbjct:    8 SEANSKRIGVVEACFGTAGQPLAIPGRVLIGEGVLTKLCRKRPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLESVTIDTVEDEGELRNGWLIKTPTKSFAVYAATATEKSEWMSHINKCVSDLLEKSGK-SPTGEHAAVWVPDSEATVCMRCQKMKFTPVNRRHHCRKCGFVVCGPCSEKKFLLPSQSSKPVRVCEFCYKQLSTG-ATLPPR 220

[Close]

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPR 738
            S ++ +RI  +E  FG +G PL+   R LIGEG+L K+CRK+PK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WM+H+ KC+ +  +K G    +   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS K++LLP QS  PVRVC+ CY+QL  G   + PR
Sbjct:    8 SEANSKRIGVVEACFGTAGQPLAIPGRVLIGEGVLTKLCRKRPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLESVTIDTVEDEGELRNGWLIKTPTKSFAVYAATATEKSEWMSHINKCVSDLLEKSGK-SPTGEHAAVWVPDSEATVCMRCQKMKFTPVNRRHHCRKCGFVVCGPCSEKKFLLPSQSSKPVRVCEFCYKQLSTG-ATLPPR 220

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Zebrafish
Match: plekhf1 (pleckstrin homology domain containing, family F (with FYVE domain) member 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1289])

HSP 1 Score: 167.548 bits (423), Expect = 3.079e-49
Identity = 89/205 (43.41%), Postives = 123/205 (60.00%), Query Frame = 1

Query:  109 ERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATK--SPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVG 717
            ERI  +E+ FG +G  L +  R L+GEG L K+CR+ P+ R F+LF+DILVYGSI++HG+    Q+II +EEV+  DL D +     + +++P+KSF + A S EEK  WM H+++      K +GL    +    +  WIPD  +  CM C    F V NRRHHCR CG +VC  CS  R +LP+ S  PVRVC  C   +  G
Sbjct:   13 ERIQAVESSFGRTGKMLQKPGRFLVGEGCLQKLCRRGPQPRVFYLFNDILVYGSIMLHGRWNNKQNIIPLEEVQQEDLEDGMAMANQWLIRTPRKSFYVSAESPEEKIAWMGHIEQYRTLHVKNKGLPAKKSGDDFATPWIPDVASAICMRCS-KRFTVANRRHHCRRCGYIVCQACSKGRAVLPHISNRPVRVCRNCKNDMTDG 216

[Close]

Query:  109 ERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATK--SPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVG 717
            ERI  +E+ FG +G  L +  R L+GEG L K+CR+ P+ R F+LF+DILVYGSI++HG+    Q+II +EEV+  DL D +     + +++P+KSF + A S EEK  WM H+++      K +GL    +    +  WIPD  +  CM C    F V NRRHHCR CG +VC  CS  R +LP+ S  PVRVC  C   +  G
Sbjct:   13 ERIQAVESSFGRTGKMLQKPGRFLVGEGCLQKLCRRGPQPRVFYLFNDILVYGSIMLHGRWNNKQNIIPLEEVQQEDLEDGMAMANQWLIRTPRKSFYVSAESPEEKIAWMGHIEQYRTLHVKNKGLPAKKSGDDFATPWIPDVASAICMRCS-KRFTVANRRHHCRRCGYIVCQACSKGRAVLPHISNRPVRVCRNCKNDMTDG 216

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Zebrafish
Match: fgd6 (FYVE, RhoGEF and PH domain containing 6 [Source:ZFIN;Acc:ZDB-GENE-041210-200])

HSP 1 Score: 116.316 bits (290), Expect = 3.801e-28
Identity = 69/198 (34.85%), Postives = 107/198 (54.04%), Query Frame = 1

Query:  163 QVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKR---------GLVGLS------ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            Q  R  + EG LMK+ RK  + R FFLF+DIL+Y + V  G+  V   ++ +  +++S  S +        ++S ++SF + A SA E+++W+  +   ID+ ++K+          L G+S       +K+P+WIPD     CM+C    F +  RRHHCR CG VVC  CS  ++ L Y      RVCD CY +L+
Sbjct:  983 QPGRVFLKEGTLMKLSRKVMQPRMFFLFNDILLYTTPVQSGQYKVNS-MLSLAGMKVSKPSQEAYQNE-LNIESVERSFILSANSATERDEWLEAIATAIDDYTRKKISFFSSRSQELEGISDDGLPLGSKAPIWIPDLRTTMCMICTCE-FTLTWRRHHCRACGKVVCQACSSNKFYLEYLKNQLARVCDHCYIKLQ 1177

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
Match: eif4g3 (eukaryotic translation initiation factor 4 gamma, 3 [Source:Xenbase;Acc:XB-GENE-1010293])

HSP 1 Score: 216.853 bits (551), Expect = 7.331e-69
Identity = 106/209 (50.72%), Postives = 140/209 (66.99%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++ +RI  +E+ FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    ++  + VWIPD+ A  CM C+   F  +NRRHHCR CG V+C  CS KR+LLP QS  PVRVCD CY+ L  G+
Sbjct:    8 SEANSKRINLVESCFGTAGQPLAIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDTIEDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVCDLISKSGKTP-NSEHAAVWIPDSEATICMRCKKVKFTPVNRRHHCRKCGYVICGPCSEKRYLLPSQSSKPVRVCDFCYDLLSNGD 215

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
Match: plekhf1 (pleckstrin homology and FYVE domain containing 1 [Source:NCBI gene;Acc:548764])

HSP 1 Score: 186.422 bits (472), Expect = 1.043e-56
Identity = 96/200 (48.00%), Postives = 127/200 (63.50%), Query Frame = 1

Query:  109 ERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            +RI  +EN FG SG PLS   R L+GEGIL K CRKKPK R FFLFSDILVYG+IV++  +   Q II +E+V +  L D I     + +K+ KKSF + A S  E+++W+ H+++CI +  +K G        +P WIPD     CM C  T F ++NRRHHCR CG VVC  CS  ++L+P     PVRVC LCY++L
Sbjct:   13 QRIAVVENCFGTSGQPLSTPGRVLVGEGILTKECRKKPKPRTFFLFSDILVYGNIVINKVRYNTQRIIPLEDVTVEILPDSIDMRNRWMIKTSKKSFVVSAASYSERKEWICHIEECIHQLLQKTGRQPSKEHAAP-WIPDKATDICMRCTQTNFTLVNRRHHCRKCGFVVCHECSKYKFLIPTIKSKPVRVCSLCYKKL 211

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
Match: mc3r (melanocortin 3 receptor [Source:Xenbase;Acc:XB-GENE-986713])

HSP 1 Score: 102.834 bits (255), Expect = 1.773e-23
Identity = 65/220 (29.55%), Postives = 114/220 (51.82%), Query Frame = 1

Query:  109 ERIIEIENMFGLSGI-PLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKS------------------PVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            +++I+I+  + L+G   + Q  R  + EG LMK+ RK  + R F+LF+D L+Y + V  G   +  +++ +  +++   + +        ++S ++SF + A SA E++ W+  +   I+E +KK+  +  + TKS                  P+WIPD     CM+C  + F +  RRHHCR CG ++C  CS  +  L Y      RVCD C++ L+
Sbjct:  985 QKLIQIQ--YSLNGHHEIVQPGRVFLKEGTLMKLSRKVMQPRMFYLFNDALLYTTPVQSGMYKLN-NMLSLAGMKVRKPTQEAY-QNELNIESVERSFILSASSASERDDWLEAISLAIEEYAKKK--ITFNPTKSLEEADPGEKEDCTLGSTAPIWIPDGRVTMCMIC-TSEFTLTWRRHHCRACGKIICQACSTNKHSLEYLKNHLARVCDRCFQVLQ 1197

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:100038050])

HSP 1 Score: 80.8777 bits (198), Expect = 3.211e-16
Identity = 53/187 (28.34%), Postives = 92/187 (49.20%), Query Frame = 1

Query:  175 KLIGEGILMKMCRKK--PKERHFFLFSDILVY--GSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWM----NHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            +LI EG ++K+  +    +ER+ FL +++L+Y      + G K   +  I +E +++ +  ++  P+  F +   +++  + A S + KE+W+    N+    I         +     ++P WI D     CM C+    A+  RRHHCR CG VVC  CS  +  L Y S    +VC  CY+ L+
Sbjct:  244 ELIKEGQILKLAARNTSAQERYLFLLNNMLLYCVPKFSLVGTKYTLRTKIGLEGMKVVETQNEDYPH-TFQISGKERTLELQASSEQNKEEWIKVSDNYYIILIYLYILYLSSISELGLRAPRWIRDNEVTMCMKCKEQFNALTRRRHHCRACGYVVCWKCSDYKATLEYDSNKMNKVCKDCYKILR 429

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:100038050])

HSP 1 Score: 77.7962 bits (190), Expect = 3.472e-15
Identity = 53/189 (28.04%), Postives = 94/189 (49.74%), Query Frame = 1

Query:  175 KLIGEGILMKMCRKK--PKERHFFLFSDILVY--GSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVS------AEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            +LI EG ++K+  +    +ER+ FL +++L+Y      + G K   +  I +E +++ +  ++  P+  F +   +++  + A+        ++ E +   + K ++E   +   +GL A   P WI D     CM C+    A+  RRHHCR CG VVC  CS  +  L Y S    +VC  CY+ L+
Sbjct:  204 ELIKEGQILKLAARNTSAQERYLFLLNNMLLYCVPKFSLVGTKYTLRTKIGLEGMKVVETQNEDYPH-TFQISGKERTLELQALRDTIAEVQQKNETFKIAIAKELEETPSEVAELGLRA---PRWIRDNEVTMCMKCKEQFNALTRRRHHCRACGYVVCWKCSDYKATLEYDSNKMNKVCKDCYKILR 388

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
Match: Plekhf2 (pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Source:MGI Symbol;Acc:MGI:1919051])

HSP 1 Score: 219.164 bits (557), Expect = 6.500e-70
Identity = 106/209 (50.72%), Postives = 138/209 (66.03%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++  RI  +E+ FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS  PVR+CD CY+ L  G+
Sbjct:    8 SEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSTGD 215

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
Match: Plekhf2 (pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Source:MGI Symbol;Acc:MGI:1919051])

HSP 1 Score: 197.208 bits (500), Expect = 6.092e-62
Identity = 97/191 (50.79%), Postives = 126/191 (65.97%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQS 666
            S ++  RI  +E+ FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS
Sbjct:    8 SEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQS 197

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
Match: Plekhf1 (pleckstrin homology domain containing, family F (with FYVE domain) member 1 [Source:MGI Symbol;Acc:MGI:1919537])

HSP 1 Score: 189.889 bits (481), Expect = 4.292e-58
Identity = 94/204 (46.08%), Postives = 129/204 (63.24%), Query Frame = 1

Query:  103 SDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKV 714
            + +RI  +E+ FG SG PL+   R L+GEG+L K CRKK K R FFLF+DILVYGSIV+  +K   QHII +EEV +  L + +     + +K+ KKSF + A S  E+++W++H+++C+       G    +   +P WIPD     CM C  T F+ L RRHHCR CG VVC+ CS +R+LLP  SP P+RVC LCY +L  
Sbjct:   11 NSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLSKRKYRSQHIIPLEEVTLEPLPETLQAKNRWMIKTAKKSFVVSAASTTERQEWISHIEECVRRQLLATGRQPTTEHAAP-WIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRERFLLPRLSPKPLRVCSLCYRELAA 213

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
Match: Fgd6 (FYVE, RhoGEF and PH domain containing 6 [Source:MGI Symbol;Acc:MGI:1261419])

HSP 1 Score: 112.849 bits (281), Expect = 6.930e-27
Identity = 70/231 (30.30%), Postives = 121/231 (52.38%), Query Frame = 1

Query:  109 ERIIEIENMFGLSGI-PLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKR----------------GLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYP 750
            +++++I+  + LSG   + Q  R  + EG LMK+ RK  + R FFLF+D L+Y + +  G   +  +++ +  +++   + +        ++S ++SF + A SA E++ W+  +   I+E +KKR                  V     K+P+WIPD  A  CM+C  + F +  RRHHCR CG +VC  CS  ++ L Y      RVC+ C+++L+  +  +SPR   P
Sbjct: 1038 QKLMQIQ--YSLSGHHEIVQPGRVFLKEGTLMKLSRKVMQPRMFFLFNDALLYTTPMQSGMYKLN-NMLSLAGMKVRKPTQEAY-QNELKIESVERSFILSASSAAERDDWLEAISSSIEEYAKKRITFCPSRSLDEDSERKEEVSPLGAKAPIWIPDTRATMCMIC-TSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVCEHCFQELQKLDHQLSPRVGSP 1263

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
Match: Fgd2 (FYVE, RhoGEF and PH domain containing 2 [Source:MGI Symbol;Acc:MGI:1347084])

HSP 1 Score: 99.7525 bits (247), Expect = 1.144e-22
Identity = 73/241 (30.29%), Postives = 115/241 (47.72%), Query Frame = 1

Query:   88 SMSNSSDERIIEIENMFGL------SGIPLSQVD--RKLIGEGILMKMC--RKKPKERHFFLFSDILVY--GSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKK--------RGLVGLS----------ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S +  S+  I E+E + GL       G+    VD    L+ EG ++K+   R  P ER+  LF+++L+Y    ++  G +   +  I++  +++ +L+D   P+  F V   +++  + A S +E   WM   Q  ID+  K+        +G  G +            ++P W+ D +   CM C+    A+  RRHHCR CG VVC+ CS  R  L Y S  P RVC  CY  L  GN
Sbjct:  282 SAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPH-SFLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNRVCLTCYTFL-TGN 520

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
Match: sp|Q9H8W4|PKHF2_HUMAN (Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1)

HSP 1 Score: 221.476 bits (563), Expect = 6.064e-70
Identity = 107/209 (51.20%), Postives = 138/209 (66.03%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++  RI  +EN FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS  PVR+CD CY+ L  G+
Sbjct:    8 SEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGD 215

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
Match: sp|Q5ZLY5|PKHF2_CHICK (Pleckstrin homology domain-containing family F member 2 OS=Gallus gallus OX=9031 GN=PLEKHF2 PE=2 SV=1)

HSP 1 Score: 220.32 bits (560), Expect = 1.716e-69
Identity = 107/208 (51.44%), Postives = 137/208 (65.87%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVG 717
            S ++  RI  +EN FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS  PVR+CD CY+ L  G
Sbjct:    8 SEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIQDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVSDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDSCYDLLSTG 214

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
Match: sp|Q91WB4|PKHF2_MOUSE (Pleckstrin homology domain-containing family F member 2 OS=Mus musculus OX=10090 GN=Plekhf2 PE=1 SV=1)

HSP 1 Score: 219.164 bits (557), Expect = 4.547e-69
Identity = 106/209 (50.72%), Postives = 138/209 (66.03%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++  RI  +E+ FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +   K G    S   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS KR+LLP QS  PVR+CD CY+ L  G+
Sbjct:    8 SEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTP-SNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSTGD 215

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
Match: sp|O76902|PKHF1_DROME (Pleckstrin homology domain-containing family F member 1 homolog OS=Drosophila melanogaster OX=7227 GN=rush PE=1 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 8.813e-68
Identity = 98/206 (47.57%), Postives = 141/206 (68.45%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            S ++  RI  +EN FG SG+PL+   R L+GEG+L KMCRK+PK R FFLF+DILVYG+IV+  KK   QHI+ +EEV +  ++D+     G+ +++  KSF ++A ++ EK++WM H+ KC+++  +K G   +    + VW+PD  A  CM C+ T F  + RRHHCR+CG VVC+ CS K++LLP QS   +RVCD CYE+LK
Sbjct:    8 SEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRKSGKKPVE-NHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLK 212

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
Match: sp|Q7ZUV1|PKHF2_DANRE (Pleckstrin homology domain-containing family F member 2 OS=Danio rerio OX=7955 GN=plekhf2 PE=2 SV=1)

HSP 1 Score: 214.157 bits (544), Expect = 4.637e-67
Identity = 105/215 (48.84%), Postives = 142/215 (66.05%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPR 738
            S ++ +RI  +E  FG +G PL+   R LIGEG+L K+CRK+PK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WM+H+ KC+ +  +K G    +   + VW+PD+ A  CM C+   F  +NRRHHCR CG VVC  CS K++LLP QS  PVRVC+ CY+QL  G   + PR
Sbjct:    8 SEANSKRIGVVEACFGTAGQPLAIPGRVLIGEGVLTKLCRKRPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLESVTIDTVEDEGELRNGWLIKTPTKSFAVYAATATEKSEWMSHINKCVSDLLEKSGK-SPTGEHAAVWVPDSEATVCMRCQKMKFTPVNRRHHCRKCGFVVCGPCSEKKFLLPSQSSKPVRVCEFCYKQLSTG-ATLPPR 220

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
Match: A0A443RKS4 (Pleckstrin domain-containing family F member 2-like protein OS=Dinothrombium tinctorium OX=1965070 GN=B4U79_06700 PE=4 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 2.709e-73
Identity = 109/202 (53.96%), Postives = 145/202 (71.78%), Query Frame = 1

Query:  112 RIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVG 717
            RI  +EN FG+SG+PL+   R L+GEGIL KMCRKKPK R FFLF+DILVYG+IV+ GKK   QHII +EEV++ DL DD     G+ +K+P KSFA+YA +  EK++WM H+Q+C+DE  K+ G    +   + VW+PDA A +CM C  + F++LNRRHHCR CG V+C  CS  ++L+P QS  PVRVCD C+++L  G
Sbjct:   14 RIANVENCFGISGVPLNIPGRVLVGEGILTKMCRKKPKPRQFFLFNDILVYGNIVLKGKKYSRQHIIPLEEVKLEDLKDDDAMQNGWLIKTPTKSFAVYAATNTEKQEWMQHIQRCVDELIKRTGK-QPTGEHAAVWVPDAEARRCMHCNKSEFSLLNRRHHCRSCGAVICGACSKHKFLIPTQSSKPVRVCDTCFDKLSKG 214

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
Match: A0A1S3IFL5 (LOW QUALITY PROTEIN: pleckstrin homology domain-containing family F member 2-like OS=Lingula unguis OX=7574 GN=LOC106163866 PE=4 SV=1)

HSP 1 Score: 226.483 bits (576), Expect = 2.749e-69
Identity = 106/205 (51.71%), Postives = 143/205 (69.76%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S+++++RI  +E  FG SG PL+   R L+GEG+L KMCRK+PK R FFLF+DILVYG+IV++ KK   QHI+ +E+V++  + D+     G+ + SP KSF +YA +A EK +WM H+ KC+ +   KRG    +   SPVWIPD+ A KCM C    F++LNRRHHCR CG VVC+ CS K+WLLP QS  P+RVC  CY+QL
Sbjct:    8 SDANNKRIAFVEQCFGSSGQPLTVPGRVLVGEGVLTKMCRKRPKPRQFFLFNDILVYGNIVINKKKYNKQHILPLEDVKLQSVEDEGSLRNGWQIISPSKSFTVYAATATEKAEWMAHINKCVQDLLAKRGKKHQAVDDSPVWIPDSEASKCMQCNRVEFSILNRRHHCRKCGRVVCNPCSSKKWLLPQQSSKPLRVCLNCYDQL 212

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
Match: A0A433TXR7 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_005843 PE=4 SV=1)

HSP 1 Score: 226.868 bits (577), Expect = 3.398e-69
Identity = 99/205 (48.29%), Postives = 147/205 (71.71%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S ++  R+  +E  FG SG PL    R L+GEG+L K+CRK+ K R FFLF+D LVYG+I++H KK   QHI+ +E+V++ +++DD     G+ + +PKKSF +YA +A EK++WM H++KC+++   +RG+    +T SPVW+PD+ A  CM C  + F+++NRRHHCRHCG+V C++C+ KRWLLP QS  P+RVC  CY++L
Sbjct:    8 SEANARRVHNVEQCFGSSGQPLGIPGRVLVGEGVLTKICRKRAKPRQFFLFNDALVYGNIIIHKKKYNKQHILALEDVKLENVNDDGNLRNGWKIINPKKSFVVYAATATEKKEWMAHIRKCVEDLLTQRGVSRSCSTDSPVWVPDSEAKNCMHCSKSEFSMVNRRHHCRHCGIVACNSCTSKRWLLPEQSTKPIRVCLTCYQKL 212

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
Match: T1G2W8 (Uncharacterized protein OS=Helobdella robusta OX=6412 GN=20215416 PE=4 SV=1)

HSP 1 Score: 224.942 bits (572), Expect = 6.569e-69
Identity = 107/205 (52.20%), Postives = 140/205 (68.29%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S ++ +RI  +E  FG+SG PL+   R L+GEG+L KMCRKKPK R FFLF+DILVYG+I+++ KK   QHII +E+V +  + D+   Y G+ + SP KSF +YA +A EK +WM H+ +CI E  K RG   +    SPVW+PD  A  CM CR + F V+NRRHHCR CG V C+ C+ KRWLLP  S  PVRVC++CYE L
Sbjct:    5 SEANSKRINFVEQCFGVSGQPLAAPRRVLVGEGVLTKMCRKKPKPRQFFLFNDILVYGNIIINKKKYNKQHIINLEDVSLESVPDEGELYNGWQIISPSKSFTVYAATAMEKVEWMAHITRCIQELHKTRGKKSMVTEASPVWVPDNNADVCMRCRKSEFNVINRRHHCRKCGFVCCNDCTNKRWLLPCISTKPVRVCNVCYESL 209

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
Match: A0A087TG54 (Pleckstrin domain-containing family F member 2 (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_12958 PE=4 SV=1)

HSP 1 Score: 228.024 bits (580), Expect = 6.696e-69
Identity = 113/205 (55.12%), Postives = 142/205 (69.27%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S ++  RI  +EN FG SG PL+   R L+GEG+L KMCRKK K R FFLF+DILVYG+IV+  KK   QHII +EEV++ +L DD I   G+ +++P KSFA+YA +A EK +WM H+ KC+D+  KK G    S   + VWIPDA A  CM CR T F VLNRRHHCR CG VVC+ CS K++LLP QS  P+RVC  CY+ L
Sbjct:    8 SEANARRIATVENCFGASGQPLAIQGRVLVGEGVLTKMCRKKGKPREFFLFNDILVYGNIVMDKKKYNKQHIIPLEEVKLENLKDDGILKNGWLIRTPTKSFAVYAATATEKMEWMAHINKCVDDLLKKTGK-KPSLEHAAVWIPDAEASVCMHCRKTQFTVLNRRHHCRKCGAVVCNPCSSKKFLLPAQSSKPLRVCLSCYDTL 211

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
Match: plekhf2 (pleckstrin homology and FYVE domain containing 2 [Source:NCBI gene;Acc:103028556])

HSP 1 Score: 216.853 bits (551), Expect = 4.603e-69
Identity = 104/205 (50.73%), Postives = 139/205 (67.80%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            S ++ +RI  +E  FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  ++D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +  +K G    +   + VW+PD+ A  CM C+   F  ++RRHHCR CG VVC  CS K++LLP QS  PVRVC+ CYEQL
Sbjct:    8 SEANSKRIAVVEGCFGTAGQPLAIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLESVTIDTVADEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHISKCVSDLLEKSGK-SPTGEHAAVWVPDSEASVCMRCQKVKFTPVSRRHHCRKCGFVVCGPCSEKKFLLPSQSSKPVRVCEFCYEQL 211

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
Match: PLEKHF1 (pleckstrin homology and FYVE domain containing 1 [Source:NCBI gene;Acc:103028531])

HSP 1 Score: 171.014 bits (432), Expect = 1.012e-50
Identity = 92/210 (43.81%), Postives = 130/210 (61.90%), Query Frame = 1

Query:  109 ERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGL-VGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISP 735
            ERI  + + FG SG  L +  R L+GEG L+K+C+++P+ R FFLF+DILVYGSIV+ G+    Q II +EEVE  DL D       + +K+P+KSF + A SAEEK+ WM H++ C +   +  G  V +    +  WIPD  +  CM C  + F V +RRHHCR CG +VC++CS  R +L   S  PVRVC LC   L+  +++ +P
Sbjct:   13 ERIQAVASSFGPSGRSLMEPGRVLVGEGRLIKLCKRRPQPRSFFLFNDILVYGSIVMGGRWNKKQQIIRLEEVEQEDLEDSAQMCNQWLLKTPRKSFYVAAASAEEKQAWMEHIENCRNLKLQSLGRPVNVQPVFAATWIPDHASAICMRCS-SRFTVTHRRHHCRCCGFIVCNSCSKARVVLKNISNKPVRVCGLCKTGLENKDKMKTP 221

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
Match: ENSAMXT00000014177.2 (FYVE, RhoGEF and PH domain-containing protein 6-like [Source:NCBI gene;Acc:103024376])

HSP 1 Score: 114.005 bits (284), Expect = 1.993e-27
Identity = 69/206 (33.50%), Postives = 108/206 (52.43%), Query Frame = 1

Query:  172 RKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLS---------------ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK---VGNEIISP 735
            R L+ EG LMK+ RK  + R FFLF+D L+Y + +  G+  +   +  +  +++S  S +        ++S ++SF + A S   +++W+  +   I++ +KK    G S                +K+P+WIPD  A  CM+C    F +  RRHHCR CG VVC  CS  ++ L Y    P RVCD C+E L+    G+ I+SP
Sbjct:  836 RTLLKEGTLMKLSRKVMQPRMFFLFNDTLLYTTPLQTGQYKLNNEL-SLAGMKVSKPSQEG-HQNELNIESVERSFILSASSPTARDEWLEAISAAINDYTKKMISFGSSRSPEEGGKDTVDAQLGSKAPIWIPDLRATMCMICTCE-FTLTWRRHHCRACGKVVCQACSTNKYPLEYLKYHPERVCDQCFETLQHNSSGSSILSP 1038

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
Match: fgd6 (FYVE, RhoGEF and PH domain containing 6 [Source:NCBI gene;Acc:103037109])

HSP 1 Score: 112.464 bits (280), Expect = 6.564e-27
Identity = 69/199 (34.67%), Postives = 107/199 (53.77%), Query Frame = 1

Query:  163 QVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYG-FCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKR---------GLVGLS------ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            Q  R  + EG LMK+ RK  + R FFLF+DIL+Y + V  G+  V   ++ +  +++S  S  +  Y     ++S ++SF + A SA E+++W+  +   I++ ++K+            GLS       +K+P+WIPD     CM+C    F +  RRHHCR CG VVC  CS  ++ L Y      RVCD CY +L+
Sbjct:  950 QPGRVFLKEGTLMKLSRKVMQPRMFFLFNDILLYTTPVQSGQYKVNS-MLSLAGMKVSKPS--LEAYQNELNIESVERSFILSASSATERDEWLEAIATAIEDYTRKKISFISSRSQESEGLSVDGPPLGSKAPIWIPDLRTTMCMICTCE-FTLTWRRHHCRACGKVVCQACSSNKYYLEYLKNQLARVCDQCYAKLQ 1144

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
Match: ENSAMXT00000054774.1 (FYVE, RhoGEF and PH domain-containing protein 4-like [Source:NCBI gene;Acc:103046578])

HSP 1 Score: 89.7373 bits (221), Expect = 2.499e-19
Identity = 59/212 (27.83%), Postives = 103/212 (48.58%), Query Frame = 1

Query:  112 RIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPK--ERHFFLFSDILVY--GSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCID----------ECSKKRGLVGLS--ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCY 699
            +++EI  M G     +     + I EG ++K+  +     +R+ FLF+++L+Y      + G+K   +  I I+ +++++  ++  P+  F V   +++  + A + ++KE W+   Q+ I+            SK+   V +S    ++P WI D     CM CR    A+  RRHHCR CG VVC  CS  +  L Y      +VC  CY
Sbjct:  326 KLLEIYEMLGEEE-DIVNASNEFIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIDGMKVAETYNEDYPH-TFQVSGKERTLELQASTQQDKEDWIKAFQETIEIFHQKNETFKTASKEVEEVSISELGKRAPRWIRDNEVTMCMKCREPFNALTRRRHHCRACGYVVCWKCSDNKASLEYDGNKMNKVCRDCY 535

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
Match: plekhf2 (pleckstrin homology domain containing, family F (with FYVE domain) member 2 [Source:NCBI gene;Acc:393214])

HSP 1 Score: 187.193 bits (474), Expect = 3.418e-58
Identity = 87/207 (42.03%), Postives = 128/207 (61.84%), Query Frame = 1

Query:   88 SMSNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            + S  +  RI  IE+ FG +G PL    R L+GEG L K+CRK PK R FFLF D++VYG+ V+  ++   Q ++ +E V I  L D+     G+ +++P KSF ++A +  E+ +W+ H+++C+ E   KRGL       +  W+PD+ A  CM  + + F  LNRRHHCR CG+VVC  CS +R+LLP QS  P+RVC  C++ L
Sbjct:    6 ASSEENCRRIARIESCFGAAGRPLMAPGRVLVGEGTLTKLCRKGPKPRQFFLFDDMVVYGAAVLGNRRYANQRVLALEAVTICTLPDEGELSNGWLMQTPAKSFKVFAATESERAEWIGHIERCVRELRAKRGLPPHGLEPAAWWVPDSSASACMRRQRSRFNALNRRHHCRKCGIVVCGACSDRRFLLPGQSSRPLRVCIDCFDSL 212

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005437.1 (pep scaffold:Pmarinus_7.0:GL486528:10206:16522:1 gene:ENSPMAG00000004933.1 transcript:ENSPMAT00000005437.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 99.3673 bits (246), Expect = 3.747e-24
Identity = 63/226 (27.88%), Postives = 110/226 (48.67%), Query Frame = 1

Query:   97 NSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRK--KPKERHFFLFSDILVY--GSIVVHGKKLVGQHIIEIEEVEISDLSD-DIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDEC-SKKRGLVGLSAT----------------KSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
            N   + ++ +  M G     +   D +L+ EGI++K   +   P+ER+ FLF+++L++    +   G++   +  I + ++E+ D++  D +P +  C    +++    A + EEK+ WM  + + I     K+   +G +A                 ++P+W+ D     CM C+     +  RRHHCR CG VVC  CS  R LL Y+     RVC+ CY QL
Sbjct:   67 NEHMQALLRVHEMLGGEVTDIVCPDTELLKEGIILKRSVRIGVPQERYLFLFNNMLLHCVPKLWSMGQRYTLRTRINVRDLEVKDVNQHDQVPTFQVC--GVQRTIDFQARTEEEKQDWMKAINEVIKTFREKEETFMGHTANVSDVSPPATQGMELGQRAPMWVRDVNVTLCMTCQDPFTTLTRRRHHCRACGKVVCWKCSDHRVLLAYEPRKLQRVCEACYAQL 290

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001934.1 (pep scaffold:Pmarinus_7.0:GL488632:1056:3278:1 gene:ENSPMAG00000001758.1 transcript:ENSPMAT00000001934.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 66.6254 bits (161), Expect = 5.987e-14
Identity = 30/66 (45.45%), Postives = 41/66 (62.12%), Query Frame = 1

Query:  502 ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCY 699
            A +  VW+ D  A  C +C    F++  R+HHCR+CG + C++CS     LP  SP PVRVCDLC+
Sbjct:   49 ALQGQVWLKDQDATNCKLCE-KEFSISRRKHHCRNCGEIFCNSCSDNELPLPS-SPKPVRVCDLCH 112

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 68.1662 bits (165), Expect = 8.263e-13
Identity = 29/64 (45.31%), Postives = 38/64 (59.38%), Query Frame = 1

Query:  520 WIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            W  D     CM C    F+V  R+HHCRHCG + C  CS +  ++P  +  PVRVCD C+E+LK
Sbjct: 1307 WAEDGEVQNCMGCG-KGFSVTVRKHHCRHCGNIFCGECSARNSMIP-SAKKPVRVCDTCFEELK 1368

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
Match: zfyve9a (zinc finger, FYVE domain containing 9a [Source:ZFIN;Acc:ZDB-GENE-070705-182])

HSP 1 Score: 63.929 bits (154), Expect = 1.754e-11
Identity = 29/69 (42.03%), Postives = 38/69 (55.07%), Query Frame = 1

Query:  502 ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQL 708
             T +P+W+PDA AP CM C+   F    RRHHCR CG V C+ C  ++  L Y      RVC  C+  +
Sbjct:    4 GTSAPMWVPDAEAPNCMRCKAR-FTFTRRRHHCRACGKVFCAPCCSQKSRLRYMENKEARVCIRCHTHI 71

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Yeast
Match: VPS27 (Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [Source:SGD;Acc:S000005289])

HSP 1 Score: 55.0694 bits (131), Expect = 7.158e-9
Identity = 32/80 (40.00%), Postives = 42/80 (52.50%), Query Frame = 1

Query:  496 LSATKSPVWIPDALAPK-------CMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLP----YQSPVPVRVCDLCYE 702
            L+ + SP  + D+  P        CM+C    F++LNR+HHCR CG V C   S     LP    Y+   PVRVCD C+E
Sbjct:  152 LTLSNSPTAMFDSKTPADWIDSDACMICS-KKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYE---PVRVCDSCFE 227

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Yeast
Match: PIB1 (RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain [Source:SGD;Acc:S000002721])

HSP 1 Score: 50.0618 bits (118), Expect = 1.530e-7
Identity = 30/84 (35.71%), Postives = 42/84 (50.00%), Query Frame = 1

Query:  520 WIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCS-------------LKRWLLPYQSPVPVRVCDLCYEQLKVGNEIIS 732
            W  D  A  C  C+ T F+ L RRHHCR CG + CS+C+             L++     +SP P R C+ CY+ L   N ++S
Sbjct:   14 WQADEEAHSCFQCK-TNFSFLVRRHHCRCCGRIFCSSCTENFVNYNKKRVHALQKKNSDVESP-PYRTCNECYDNLLHLNLLVS 95

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Yeast
Match: FAB1 (1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis [Source:SGD;Acc:S000001915])

HSP 1 Score: 50.0618 bits (118), Expect = 3.548e-7
Identity = 23/62 (37.10%), Postives = 32/62 (51.61%), Query Frame = 1

Query:  520 WIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQ 705
            W+ D  + +C  C  T F    R+HHCR CG + CS+C+L      +     +RVC  CYE 
Sbjct:  237 WMKDESSKECFSCGKT-FNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRVCYNCYEH 297

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
Match: EDO38501 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCW3])

HSP 1 Score: 209.534 bits (532), Expect = 9.268e-67
Identity = 106/219 (48.40%), Postives = 137/219 (62.56%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPL--SQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFP 744
            S ++  RI  +++ FG SG PL      R L+GEG+L K+CRKKPK R FFLF+DILVYG+IV++ KK   QHII +EE+++  L DD     G+ + S KKSFA+YA +A EK +WM H+ KCI +   K G        + VW+PD+ A  CM C  T F  +NRRHHCR CG VVC  CS K++LLP QS  P+RVC+ CY  L        PR P
Sbjct:    8 SEANKRRIQHVQSCFGSSGQPLWLENKSRVLVGEGVLTKLCRKKPKPRQFFLFNDILVYGNIVINKKKYNKQHIIPLEEIKLLTLEDDGNLKNGWQIISTKKSFAVYAATATEKAEWMAHINKCIQDLLAKTGKKA-GGVHAAVWVPDSEASTCMSCMKTKFTAINRRHHCRKCGAVVCGACSTKKFLLPAQSSKPLRVCNSCYNTL----SNTKPRAP 221

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
Match: EDO48232 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKE8])

HSP 1 Score: 122.865 bits (307), Expect = 2.049e-31
Identity = 80/237 (33.76%), Postives = 118/237 (49.79%), Query Frame = 1

Query:   97 NSSDERIIEIENMFGLSGIPLSQVD-----RKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKK-------LVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKK--------RGLVGLS-----ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIIS 732
            N S +R+   E +  + G  +   +     R+ I +G L+K+CRK  +ER FFL +D+L+Y + V   +        L+G  +I  E  E  +          F + S  +SF + A ++ E+++W+  L++ I+  +KK         G+   S       K+PVWIPDA    CM+C    F V NRRHHCR CG VVC +CS     L Y      RVCD+CYE L  G E +S
Sbjct:  184 NESMKRVDNFEQVLRIQGSLVGHEEIVRPGREFIKQGNLLKLCRKDMQERTFFLLTDVLLYTAPVGGNQYKLRETLPLLGMKVILPESQEFVN---------EFSIISTTRSFTLSASTSAERDEWLEELERAINAMTKKKISFFKSKEGITQDSEDTKLGEKAPVWIPDARVTMCMLC-TDDFTVTNRRHHCRGCGKVVCGSCSDNLAPLTYLDYAQARVCDMCYEVLLRGKEQLS 410

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
Match: EDO33626 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRN5])

HSP 1 Score: 63.1586 bits (152), Expect = 5.493e-11
Identity = 41/119 (34.45%), Postives = 66/119 (55.46%), Query Frame = 1

Query:  109 ERIIEIE-NMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVY---GSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQ 453
            ++IIE++ ++ G+    L Q  R+ I EG L KM RK P+ R FFLFSD+L+Y   G  + +  ++ GQ  I +  V++ D   ++   + F +    K   + A S EEK +W+  LQ
Sbjct:  895 QKIIELQRDLIGVDN--LVQQGREFIREGCLQKMTRKGPQPRMFFLFSDLLLYTCKGVTLTNQFRVRGQ--IPLHTVKLEDTGPELHGLFPFNINFSNKHMTVAAPSEEEKYKWLEDLQ 1009

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
Match: EDO48184 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK38])

HSP 1 Score: 58.9214 bits (141), Expect = 7.530e-11
Identity = 30/72 (41.67%), Postives = 38/72 (52.78%), Query Frame = 1

Query:  502 ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVG 717
             TK+P WI D     CM+C   +F +  RRHHCR CG + C+ CS  +  L Y+     RVC  C E L  G
Sbjct:    7 GTKAPAWIRDESVTMCMLCD-ALFTLTRRRHHCRACGGIYCNACSHNKAPLEYRDGKLCRVCRSCREILVHG 77

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
Match: EDO39875 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8S0])

HSP 1 Score: 57.3806 bits (137), Expect = 5.071e-10
Identity = 24/50 (48.00%), Postives = 37/50 (74.00%), Query Frame = 1

Query:  571 FAVLNRRHHCRHCGVVVCSTCSLKRW-LLPYQSPVPVRVCDLCYEQLKVG 717
            F++ +R+HHCRHCG ++C+ CS K+  ++ Y+   PVRVCD+C+E L  G
Sbjct:  122 FSIKHRKHHCRHCGRLLCAKCSCKQIPIIKYELAKPVRVCDVCFEMLTSG 171

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
Match: plekhf2 (pleckstrin homology and FYVE domain containing 2 [Source:NCBI gene;Acc:101160441])

HSP 1 Score: 214.157 bits (544), Expect = 5.587e-68
Identity = 105/209 (50.24%), Postives = 140/209 (66.99%), Query Frame = 1

Query:   94 SNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGN 720
            S ++ +RI  +E+ FG +G PL+   R LIGEG+L K+CRKKPK R FFLF+DILVYG+IV+  KK   QHII +E V I  + D+     G+ +K+P KSFA+YA +A EK +WMNH+ KC+ +  +K G    +   + VW+PD+ A  CM C    F  +NRRHHCR CG VVC+ CS K++LLP QS  PVRVC+ CY QL  G+
Sbjct:    8 SEANSKRIGMVESCFGAAGQPLAIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLESVTIDTVPDEGDLRNGWLIKTPTKSFAVYAATATEKCEWMNHIGKCVKDLLQKSGK-SPTGEHAAVWVPDSEASVCMRCLKVKFTAVNRRHHCRKCGYVVCNPCSEKKYLLPSQSSKPVRVCEFCYAQLTSGS 215

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
Match: ENSORLT00000018711.2 (pleckstrin homology domain-containing family F member 1-like [Source:NCBI gene;Acc:101175000])

HSP 1 Score: 148.288 bits (373), Expect = 2.584e-42
Identity = 82/215 (38.14%), Postives = 125/215 (58.14%), Query Frame = 1

Query:   79 PYKSMSNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSP-VPVRVCDLCYEQLKVGN 720
            PY    + +   I E++  F     PL Q  R L+G+G LMK  RKK   + FFLF+D+LVYGSI++  +    Q +I +E++++ DL D     + + + SP KSF + A+S EEK+ WM H+++C     +  G    S+  +P WIPD ++ +CM C  T+F++  R+HHCR CG +VCS CS  R ++    P   VRVC LC ++ +  N
Sbjct:    3 PYLVFDSENRRLIGELDKSFSPPRQPLLQPGRVLLGKGSLMKQGRKKWDLKAFFLFNDVLVYGSIIMKDRWFKKQKVIRLEDIKMEDLEDSEDFKHQWLICSPTKSFFVSALSLEEKKAWMEHIEECRRNLLQGGGCTP-SSRYAPTWIPDHVSQRCMRC-FTIFSLSKRKHHCRSCGFLVCSQCSKARAVIDALHPKKEVRVCKLCNKKGEEDN 215

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
Match: ENSORLT00000040317.1 (pleckstrin homology domain-containing family F member 1-like [Source:NCBI gene;Acc:101175000])

HSP 1 Score: 147.517 bits (371), Expect = 2.996e-42
Identity = 82/210 (39.05%), Postives = 126/210 (60.00%), Query Frame = 1

Query:   97 NSSDERII-EIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVP-VRVCDLCYEQLKVGN 720
            +S + R+I E++  F     PL Q  R L+G+G LMK  RKK   + FFLF+D+LVYGSI++  +    Q +I +E++++ DL D     + + + SP KSF + A+S EEK+ WM H+++C     +  G    S+  +P WIPD ++ +CM C  T+F++  R+HHCR CG +VCS CS  R ++    P   VRVC LC ++ +  N
Sbjct:    7 DSENRRLIGELDKSFSPPRQPLLQPGRVLLGKGSLMKQGRKKWDLKAFFLFNDVLVYGSIIMKDRWFKKQKVIRLEDIKMEDLEDSEDFKHQWLICSPTKSFFVSALSLEEKKAWMEHIEECRRNLLQGGGCTP-SSRYAPTWIPDHVSQRCMRC-FTIFSLSKRKHHCRSCGFLVCSQCSKARAVIDALHPKKEVRVCKLCNKKGEEDN 214

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BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
Match: fgd6 (FYVE, RhoGEF and PH domain-containing protein 6 [Source:NCBI gene;Acc:101165435])

HSP 1 Score: 119.783 bits (299), Expect = 1.934e-29
Identity = 69/200 (34.50%), Postives = 109/200 (54.50%), Query Frame = 1

Query:  163 QVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSA-----------------TKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            Q  R  + EG LMK+ RK  + R FFLF+D L+Y + V  G+  +   ++ +  +++S  S +        ++S ++SF + A SA E+++W+  + K ID+ +KK+ +  +S+                 +K+P+WIPD  A  CM+C    F +  RRHHCR CG VVC  CS  ++ L Y    P RVCD C+ +LK
Sbjct:  938 QPGRVFLKEGTLMKLSRKVMQPRMFFLFNDALMYTTPVQSGQYKLNS-VLSLAGMKVSKPSQEAYQNE-LNIESVERSFILSASSATERDEWLEAIAKAIDDYTKKK-ITFISSRSQEEAEVFVDNGAPLGSKAPIWIPDLRATMCMICTCE-FTLTWRRHHCRACGKVVCQACSTNKYYLEYLKNQPARVCDHCFAKLK 1133

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
Match: FGD6 (FYVE, RhoGEF and PH domain-containing protein 6 [Source:NCBI gene;Acc:101155348])

HSP 1 Score: 114.775 bits (286), Expect = 1.118e-27
Identity = 67/198 (33.84%), Postives = 108/198 (54.55%), Query Frame = 1

Query:  163 QVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLS---------------ATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLK 711
            Q  R    EGILMK+ RK  + R FFLF+DIL+Y   V  G+  + ++++ +  +++S  + +        ++S ++SF + A SA E++ W+N +   I++ +KK+ +  LS                +K+P+WIPD     CM+C  + F +  RRHHCR CG V+C  CS  +  L Y      RVCDLC++ L+
Sbjct:  843 QPGRIFFKEGILMKLSRKVMQPRMFFLFNDILLYTKPVQTGQYKL-KNMLSLAGMKVSKPNQEAYQNE-LNIESVERSFILSASSATERDDWLNSISAAINDFTKKK-ITFLSGNPANEADLTDGTPLGSKAPIWIPDPRTTMCMICT-SEFTLTWRRHHCRACGKVICQGCSSNKHYLQYMKKSD-RVCDLCFQTLR 1035

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Planmine SMEST
Match: SMESG000038764.1 (SMESG000038764.1)

HSP 1 Score: 479.945 bits (1234), Expect = 1.320e-172
Identity = 261/261 (100.00%), Postives = 261/261 (100.00%), Query Frame = 1

Query:   91 MSNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYPPIKNNXXXXXXXXXXXXXXXXXNQSINLLNLTNPNISQILE 873
            MSNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYPPIKNNTEDYLSETSSEDSDYDENQSINLLNLTNPNISQILE
Sbjct:    1 MSNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYPPIKNNTEDYLSETSSEDSDYDENQSINLLNLTNPNISQILE 261

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Planmine SMEST
Match: SMESG000038764.1 (SMESG000038764.1)

HSP 1 Score: 451.44 bits (1160), Expect = 1.346e-161
Identity = 247/247 (100.00%), Postives = 247/247 (100.00%), Query Frame = 1

Query:  133 MFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYPPIKNNXXXXXXXXXXXXXXXXXNQSINLLNLTNPNISQILE 873
            MFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYPPIKNNTEDYLSETSSEDSDYDENQSINLLNLTNPNISQILE
Sbjct:    1 MFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPRFPYPPIKNNTEDYLSETSSEDSDYDENQSINLLNLTNPNISQILE 247

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Planmine SMEST
Match: SMESG000028452.1 (SMESG000028452.1)

HSP 1 Score: 206.068 bits (523), Expect = 3.280e-65
Identity = 101/215 (46.98%), Postives = 144/215 (66.98%), Query Frame = 1

Query:   91 MSNSS--DERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFFLFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPKKSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQ--LKVGNE 723
            M+N +  + RI  +EN+FG++G+PL   +R+LIGEG+L K+CR+KPK+RHFFLF+DILVYG+I+++ KKL  QHI E+E + + ++  +    + F V +PKKSF + AVS +E+ QW+ H++K   EC  K           PVWIPD  A KCM C LT F+ + RRHHCR CG VVC+ CS ++ +LP QS   +RVC  C+ Q  +K+ N 
Sbjct:    1 MANQTVIESRIKYVENLFGVNGMPLYNSNRELIGEGVLFKLCRRKPKQRHFFLFNDILVYGNIILYKKKLTSQHIFELESLTVEEVKGNENFPFQFKVMTPKKSFIICAVSEDERTQWILHIRKYSKECETKTLSRNKPVGFCPVWIPDTEAMKCMTCNLTEFSWIQRRHHCRSCGNVVCAKCSQQKIILPNQSHNALRVCVRCFLQNNIKIDNN 215

[Close]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Planmine SMEST
Match: SMESG000019696.1 (SMESG000019696.1)

HSP 1 Score: 72.7886 bits (177), Expect = 1.128e-13
Identity = 33/73 (45.21%), Postives = 43/73 (58.90%), Query Frame = 1

Query:  520 WIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPR 738
            WI D  AP CM C+  VF++ NRRHHCR CG VVC  CS  R ++     V VR+C  C++ +   N+  S R
Sbjct: 2282 WIQDRDAPVCMCCKKEVFSMFNRRHHCRKCGWVVCGVCSTHRTMI---KGVTVRICTKCHKSIH-DNQYFSSR 2350

[Close]

Query:  520 WIPDALAPKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCDLCYEQLKVGNEIISPR 738
            WI D  AP CM C+  VF++ NRRHHCR CG VVC  CS  R ++     V VR+C  C++ +   N+  S R
Sbjct: 2283 WIQDRDAPVCMCCKKEVFSMFNRRHHCRKCGWVVCGVCSTHRTMI---KGVTVRICTKCHKSIH-DNQYFSSR 2351

The following BLAST results are available for this feature:

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Human
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Celegans
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Zebrafish
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Yeast
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
BLAST of Pleckstrin homology domain-containing family F member 2 vs. Planmine SMEST

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PLEKHF2	1.263e-70	51.20	pleckstrin homology and FYVE domain containing 2 [...	[more]
PLEKHF2	1.263e-70	51.20	pleckstrin homology and FYVE domain containing 2 [...	[more]
PLEKHF1	1.895e-59	47.52	pleckstrin homology and FYVE domain containing 1 [...	[more]
PLEKHF1	1.895e-59	47.52	pleckstrin homology and FYVE domain containing 1 [...	[more]
PLEKHF1	3.857e-30	46.61	pleckstrin homology and FYVE domain containing 1 [...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ZK632.12	2.237e-63	46.34	pep chromosome:WBcel235:III:9830802:9832378:1 gene...	[more]
ZK632.12	2.237e-63	46.34	pep chromosome:WBcel235:III:9830792:9832430:1 gene...	[more]
aka-1	1.539e-12	43.66	A Kinase Anchor protein [Source:UniProtKB/TrEMBL;...	[more]
aka-1	1.539e-12	43.66	A Kinase Anchor protein [Source:UniProtKB/TrEMBL;...	[more]
aka-1	6.498e-11	50.00	A Kinase Anchor protein [Source:UniProtKB/TrEMBL;...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rush	8.792e-69	47.57	gene:FBgn0025381 transcript:FBtr0070259	[more]
rush	8.792e-69	47.57	gene:FBgn0025381 transcript:FBtr0339589	[more]
Sara	3.024e-13	45.16	gene:FBgn0026369 transcript:FBtr0071641	[more]
CG6051	4.807e-13	46.91	gene:FBgn0039492 transcript:FBtr0339264	[more]
CG6051	4.896e-13	46.91	gene:FBgn0039492 transcript:FBtr0305050	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
plekhf2	6.143e-68	48.84	pleckstrin homology domain containing, family F (w...	[more]
plekhf2	6.143e-68	48.84	pleckstrin homology domain containing, family F (w...	[more]
plekhf1	3.079e-49	43.41	pleckstrin homology domain containing, family F (w...	[more]
plekhf1	3.079e-49	43.41	pleckstrin homology domain containing, family F (w...	[more]
fgd6	3.801e-28	34.85	FYVE, RhoGEF and PH domain containing 6 [Source:ZF...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eif4g3	7.331e-69	50.72	eukaryotic translation initiation factor 4 gamma, ...	[more]
plekhf1	1.043e-56	48.00	pleckstrin homology and FYVE domain containing 1 [...	[more]
mc3r	1.773e-23	29.55	melanocortin 3 receptor [Source:Xenbase;Acc:XB-GEN...	[more]
FGD4	3.211e-16	28.34	FYVE, RhoGEF and PH domain containing 4 [Source:NC...	[more]
FGD4	3.472e-15	28.04	FYVE, RhoGEF and PH domain containing 4 [Source:NC...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Plekhf2	6.500e-70	50.72	pleckstrin homology domain containing, family F (w...	[more]
Plekhf2	6.092e-62	50.79	pleckstrin homology domain containing, family F (w...	[more]
Plekhf1	4.292e-58	46.08	pleckstrin homology domain containing, family F (w...	[more]
Fgd6	6.930e-27	30.30	FYVE, RhoGEF and PH domain containing 6 [Source:MG...	[more]
Fgd2	1.144e-22	30.29	FYVE, RhoGEF and PH domain containing 2 [Source:MG...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9H8W4\|PKHF2_HUMAN	6.064e-70	51.20	Pleckstrin homology domain-containing family F mem...	[more]
sp\|Q5ZLY5\|PKHF2_CHICK	1.716e-69	51.44	Pleckstrin homology domain-containing family F mem...	[more]
sp\|Q91WB4\|PKHF2_MOUSE	4.547e-69	50.72	Pleckstrin homology domain-containing family F mem...	[more]
sp\|O76902\|PKHF1_DROME	8.813e-68	47.57	Pleckstrin homology domain-containing family F mem...	[more]
sp\|Q7ZUV1\|PKHF2_DANRE	4.637e-67	48.84	Pleckstrin homology domain-containing family F mem...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A443RKS4	2.709e-73	53.96	Pleckstrin domain-containing family F member 2-lik...	[more]
A0A1S3IFL5	2.749e-69	51.71	LOW QUALITY PROTEIN: pleckstrin homology domain-co...	[more]
A0A433TXR7	3.398e-69	48.29	Uncharacterized protein OS=Elysia chlorotica OX=18...	[more]
T1G2W8	6.569e-69	52.20	Uncharacterized protein OS=Helobdella robusta OX=6...	[more]
A0A087TG54	6.696e-69	55.12	Pleckstrin domain-containing family F member 2 (Fr...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
plekhf2	4.603e-69	50.73	pleckstrin homology and FYVE domain containing 2 [...	[more]
PLEKHF1	1.012e-50	43.81	pleckstrin homology and FYVE domain containing 1 [...	[more]
ENSAMXT00000014177.2	1.993e-27	33.50	FYVE, RhoGEF and PH domain-containing protein 6-li...	[more]
fgd6	6.564e-27	34.67	FYVE, RhoGEF and PH domain containing 6 [Source:NC...	[more]
ENSAMXT00000054774.1	2.499e-19	27.83	FYVE, RhoGEF and PH domain-containing protein 4-li...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
plekhf2	3.418e-58	42.03	pleckstrin homology domain containing, family F (w...	[more]
ENSPMAT00000005437.1	3.747e-24	27.88	pep scaffold:Pmarinus_7.0:GL486528:10206:16522:1 g...	[more]
ENSPMAT00000001934.1	5.987e-14	45.45	pep scaffold:Pmarinus_7.0:GL488632:1056:3278:1 gen...	[more]
eea1	8.263e-13	45.31	early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]
zfyve9a	1.754e-11	42.03	zinc finger, FYVE domain containing 9a [Source:ZFI...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
VPS27	7.158e-9	40.00	Endosomal protein that forms a complex with Hse1p;...	[more]
PIB1	1.530e-7	35.71	RING-type ubiquitin ligase of the endosomal and va...	[more]
FAB1	3.548e-7	37.10	1-phosphatidylinositol-3-phosphate 5-kinase; vacuo...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO38501	9.268e-67	48.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48232	2.049e-31	33.76	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33626	5.493e-11	34.45	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48184	7.530e-11	41.67	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39875	5.071e-10	48.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
plekhf2	5.587e-68	50.24	pleckstrin homology and FYVE domain containing 2 [...	[more]
ENSORLT00000018711.2	2.584e-42	38.14	pleckstrin homology domain-containing family F mem...	[more]
ENSORLT00000040317.1	2.996e-42	39.05	pleckstrin homology domain-containing family F mem...	[more]
fgd6	1.934e-29	34.50	FYVE, RhoGEF and PH domain-containing protein 6 [S...	[more]
FGD6	1.118e-27	33.84	FYVE, RhoGEF and PH domain-containing protein 6 [S...	[more]

BLAST of Pleckstrin homology domain-containing family F member 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000038764.1	1.320e-172	100.00	SMESG000038764.1	[more]
SMESG000038764.1	1.346e-161	100.00	SMESG000038764.1	[more]
SMESG000028452.1	3.280e-65	46.98	SMESG000028452.1	[more]
SMESG000019696.1	1.128e-13	45.21	SMESG000019696.1	[more]
SMESG000019696.1	1.128e-13	45.21	SMESG000019696.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30003223 ID=SMED30003223|Name=Pleckstrin homology domain-containing family F member 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1007bp
GATTATTTGAATTATAATTTTTGGAATAATTAATTTAAAATTTATTTAAC
GTATAATTTATTAATAATTTAACAAATACCTTATAAATCGATGAGCAATA
GCAGTGATGAAAGGATAATAGAAATAGAAAATATGTTTGGTTTATCTGGA
ATCCCACTCAGTCAAGTCGACAGAAAACTAATAGGCGAAGGAATATTAAT
GAAAATGTGTAGGAAAAAACCAAAAGAACGCCATTTTTTCTTATTCTCAG
ACATCCTCGTTTACGGAAGTATAGTAGTTCACGGTAAAAAGTTAGTAGGC
CAACACATCATCGAAATAGAAGAGGTAGAAATCAGTGATCTCAGTGATGA
TATAATTCCTTATTATGGATTTTGTGTCAAAAGTCCAAAAAAATCTTTTG
CGATGTACGCTGTTTCAGCTGAAGAAAAAGAGCAGTGGATGAATCATTTA
CAAAAGTGTATTGATGAGTGTTCTAAAAAACGTGGTTTAGTCGGCTTATC
TGCCACAAAATCCCCAGTTTGGATTCCCGATGCCTTAGCTCCGAAATGTA
TGGTCTGTCGCCTTACAGTTTTCGCTGTATTGAATAGAAGACACCACTGC
AGACATTGTGGAGTCGTAGTATGCAGCACCTGTTCATTAAAGCGGTGGTT
ATTGCCATACCAGTCGCCTGTACCAGTAAGGGTCTGTGATTTGTGCTACG
AGCAACTGAAAGTTGGAAATGAGATTATCAGTCCCCGATTCCCGTATCCA
CCTATCAAAAACAATACGGAAGATTATTTATCAGAAACCTCAAGCGAGGA
TTCGGATTATGATGAGAATCAGTCTATCAATCTGCTCAATTTGACAAATC
CGAATATATCTCAAATTTTGGAATAAATAAAATGCAAATGTCCCGACTTG
TAAATGACAGATTTGATTGCCATTATTTCATTGGAAATGGAAATTTTATT
ATTTTACTTAATCCAAATTTTTTACCGAATCTTGTAACTTTTTACAATTA
TTTTTAT

protein sequence of SMED30003223-orf-1

>SMED30003223-orf-1 ID=SMED30003223-orf-1|Name=SMED30003223-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=262bp
MSNSSDERIIEIENMFGLSGIPLSQVDRKLIGEGILMKMCRKKPKERHFF
LFSDILVYGSIVVHGKKLVGQHIIEIEEVEISDLSDDIIPYYGFCVKSPK
KSFAMYAVSAEEKEQWMNHLQKCIDECSKKRGLVGLSATKSPVWIPDALA
PKCMVCRLTVFAVLNRRHHCRHCGVVVCSTCSLKRWLLPYQSPVPVRVCD
LCYEQLKVGNEIISPRFPYPPIKNNTEDYLSETSSEDSDYDENQSINLLN
LTNPNISQILE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0016021	integral component of membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0031901	early endosome membrane

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte

Vocabulary: **INTERPRO**
Term	Definition
IPR001849	PH_domain
IPR000306	Znf_FYVE
IPR011993	PH-like_dom_sf
IPR013083	Znf_RING/FYVE/PHD
IPR017455	Znf_FYVE-rel
IPR011011	Znf_FYVE_PHD

Vocabulary: **molecular function**
Term	Definition
GO:0046872	metal ion binding
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0006810	transport
GO:0015031	protein transport

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001849	Pleckstrin homology domain	SMART	SM00233	PH_update	coord: 30..127 e-value: 1.1E-13 score: 61.5
IPR001849	Pleckstrin homology domain	PFAM	PF00169	PH	coord: 33..124 e-value: 2.7E-8 score: 34.2
IPR001849	Pleckstrin homology domain	PROSITE	PS50003	PH_DOMAIN	coord: 29..125 score: 11.372
IPR000306	FYVE zinc finger	SMART	SM00064	fyve_4	coord: 139..208 e-value: 3.6E-25 score: 99.6
IPR000306	FYVE zinc finger	PFAM	PF01363	FYVE	coord: 143..207 e-value: 5.5E-18 score: 64.9
IPR011993	PH-like domain superfamily	GENE3D	G3DSA:2.30.29.30		coord: 22..122 e-value: 3.4E-22 score: 80.8
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 134..216 e-value: 6.9E-23 score: 82.1
None	No IPR available	PANTHER	PTHR46280	FAMILY NOT NAMED	coord: 6..218
None	No IPR available	SUPERFAMILY	SSF50729	PH domain-like	coord: 11..127
IPR017455	Zinc finger, FYVE-related	PROSITE	PS50178	ZF_FYVE	coord: 147..207 score: 12.312
IPR011011	Zinc finger, FYVE/PHD-type	SUPERFAMILY	SSF57903	FYVE/PHD zinc finger	coord: 142..213