uroporphyrinogen decarboxylase

Overview
Nameuroporphyrinogen decarboxylase
Smed IDSMED30003163
Length (bp)1255
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of uroporphyrinogen decarboxylase (SMED30003163) t-SNE clustered cells

Violin plots show distribution of expression levels for uroporphyrinogen decarboxylase (SMED30003163) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of uroporphyrinogen decarboxylase (SMED30003163) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for uroporphyrinogen decarboxylase (SMED30003163) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30003163

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neoblastSMED30003163SMESG000018128.1 dd_Smed_v4_3392_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Human
Match: UROD (uroporphyrinogen decarboxylase [Source:HGNC Symbol;Acc:HGNC:12591])

HSP 1 Score: 400.979 bits (1029), Expect = 4.069e-138
Identity = 199/373 (53.35%), Postives = 249/373 (66.76%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F +F+LPY+R++A  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG  +YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Human
Match: UROD (uroporphyrinogen decarboxylase [Source:HGNC Symbol;Acc:HGNC:12591])

HSP 1 Score: 375.555 bits (963), Expect = 1.303e-128
Identity = 187/348 (53.74%), Postives = 234/348 (67.24%), Query Frame = 3 
Query:  168 MRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F +F+LPY+R++A  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG  +YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:    1 MRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 332
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Human
Match: UROD (uroporphyrinogen decarboxylase [Source:HGNC Symbol;Acc:HGNC:12591])

HSP 1 Score: 359.762 bits (922), Expect = 2.745e-122
Identity = 183/373 (49.06%), Postives = 231/373 (61.93%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQ                                    A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F +F+LPY+R++A  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG  +YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQ------------------------------------ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 346
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Human
Match: UROD (uroporphyrinogen decarboxylase [Source:HGNC Symbol;Acc:HGNC:12591])

HSP 1 Score: 337.806 bits (865), Expect = 6.002e-114
Identity = 178/373 (47.72%), Postives = 218/373 (58.45%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ                                               I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG  +YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ-----------------------------------------------IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 321
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Human
Match: UROD (uroporphyrinogen decarboxylase [Source:HGNC Symbol;Acc:HGNC:12591])

HSP 1 Score: 315.464 bits (807), Expect = 1.386e-105
Identity = 158/303 (52.15%), Postives = 201/303 (66.34%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGA 1001
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F +F+LPY+R++A  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ ARR  G+
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARRRSGS 297
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Fly
Match: Updo (gene:FBgn0033428 transcript:FBtr0088524)

HSP 1 Score: 365.54 bits (937), Expect = 1.002e-124
Identity = 192/370 (51.89%), Postives = 246/370 (66.49%), Query Frame = 3 
Query:   75 MISGDEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIH 1184
            M     FPVLKND ++R+A G  V++VPVW+MRQAGRYLPEF++LR+ +DFFT+C+TPELACE+T+QP+ RF LDA+IIF DILVIPQ               A+G TVEM  G GPV+P P+   +DL  L  D  +  +L YV DAI + RHKL GR PLIGF G PWTLM YMIEGGGS T SKAK WL      S  FL+ LT  I  +L  QVKAGAQ+LQVFES A  LS +QF ++ +PYL+ I   L   + K  +   VP+ +FAK A +++++ S+L YDV+ LDWT+ P  AR +VG N+TLQGNLDP  +Y   + + + T +M+  FG  +YIANLGHGI P      +E  V A+H
Sbjct:    1 MKDAKPFPVLKNDNLLRAARGEVVDRVPVWVMRQAGRYLPEFQELRKHHDFFTVCRTPELACEVTMQPLRRFDLDASIIFSDILVIPQ---------------ALGLTVEMHAGVGPVLPQPIVVPEDLKRLTPDGALS-RLSYVGDAITMMRHKLEGRVPLIGFTGAPWTLMGYMIEGGGSKTMSKAKAWLNEHPEDSKLFLNLLTDAIVDYLEMQVKAGAQMLQVFESSAEHLSKEQFLQWCVPYLKRIRDELVDRLTKKAIP-VVPMTLFAKGAGHSLKEQSELGYDVIGLDWTVDPLEARNLVGPNITLQGNLDPQDMYRDPDELRNLTTEMVHKFGKSRYIANLGHGITPQTPITSMEVLVEAVH 353
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Zebrafish
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:30617])

HSP 1 Score: 426.017 bits (1094), Expect = 4.582e-148
Identity = 213/372 (57.26%), Postives = 259/372 (69.62%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMI 1205
            +FP L+ND  +R+A G  +E +PVW MRQAGRYLPEFR+ R   DFF  C++PE  CE+TLQP+ RF  DAAIIF DILV+PQ               A+G  V+M PGKGP  P P+ + +DL  L   VDV  +L YVF AI LTRHK+ G+ PLIGF G PWTLM+YMIEGGGS T SKAK+WLY     SH  LS+LT +I ++LL QVKAGAQ LQVFESH G L P +F EFSLPYLR+IA  +K +I +  L D VP+IVFAKD HY +EDLS+  Y+VV LDWTI PR AR   G  V+LQGN+DPCALY + E I    R+ML+ FG + YIANLGHG+YPDMDP  V  FV A+H  S +++
Sbjct:   12 DFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLPEFRESRAGKDFFETCRSPEACCELTLQPLRRFPFDAAIIFSDILVVPQ---------------AMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPLIGFTGAPWTLMSYMIEGGGSATHSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQALQVFESHTGCLGPVEFKEFSLPYLRDIARRVKDKIKESGL-DNVPMIVFAKDGHYGLEDLSESAYEVVGLDWTIDPRSARVRTGGKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEAVHNHSRQLL 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Xenopus
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:496978])

HSP 1 Score: 429.869 bits (1104), Expect = 2.021e-149
Identity = 213/369 (57.72%), Postives = 261/369 (70.73%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEE 1199
            FP L ND  +R+A G     VPVW MRQAGRYLPEFR+ R   DFF  C++PE+ CE+TLQP+ RF LDAAIIF DILVIPQ               A+G  + M+PG+GPV P P+    DL+ L   VDV  +L YVF AI LTRHK+ G+ PLIGF G PWTLM YMIEGGGSNT SKAK+WLY     SH  L +LT +I ++L+ QV AGAQ LQVFESHAG L P QF++FSLPYLR+I+  +K ++    L D+VP+IVFAKDAHYA+EDLS+  Y+VV LDWTI+P+ AR   G  VTLQGN+DPCALY+S E I    +KM++ FG + YIANLGHG+YPDMDP  V  F+SA+H  S++
Sbjct:   17 FPPLHNDTFLRAARGEECNHVPVWCMRQAGRYLPEFRETRAGQDFFASCRSPEICCELTLQPLRRFPLDAAIIFSDILVIPQ---------------ALGMEIRMEPGRGPVFPEPLQTPQDLHKLRSSVDVSEELGYVFRAITLTRHKIEGKVPLIGFTGAPWTLMTYMIEGGGSNTMSKAKRWLYQHPSASHQLLKQLTDVIVEYLVGQVAAGAQALQVFESHAGCLGPQQFSDFSLPYLRDISRRVKHKLKAEGL-DQVPMIVFAKDAHYALEDLSQSGYEVVGLDWTIRPQEARERTGKRVTLQGNMDPCALYASKEDIEKTVKKMIEGFGQRGYIANLGHGLYPDMDPDHVGAFISAVHKYSQQ 369
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Xenopus
Match: ENSXETT00000030380.1 (uroporphyrinogen decarboxylase-like [Source:NCBI gene;Acc:101734235])

HSP 1 Score: 300.056 bits (767), Expect = 1.767e-99
Identity = 166/305 (54.43%), Postives = 205/305 (67.21%), Query Frame = 3 
Query:  186 YLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSE-TRKMLQTFG 1097
            YLP     R  Y +  IC+   + C I LQP+ RF LDAAIIF DILVIPQ               A+G  + M+PG+GPV P P+    DL+ L   VDV  +L YVF AI LTRHK+ G+ PLIGF G PWTLM YMIEGGGSNT SKAK+WLY     SH  L +LT +I ++L+ QV AGAQ LQVFESHAG L P QF++FSLPYLR+I+  +K ++    L D+VP+IVFAKDAHYA+EDLS+  Y+VV LDWTI+P+ AR   G  VTLQGN+DPCALY+S  + V +   +ML  +G
Sbjct:    2 YLP-----RNSYYYADICR---IFC-IFLQPLRRFPLDAAIIFSDILVIPQ---------------ALGMEIRMEPGRGPVFPEPLQTPQDLHKLRSSVDVSEELGYVFHAITLTRHKIEGKVPLIGFTGAPWTLMTYMIEGGGSNTMSKAKRWLYQHPSASHQLLKQLTDVIVEYLVGQVAAGAQALQVFESHAGCLGPQQFSDFSLPYLRDISRRVKHKLKAEGL-DQVPMIVFAKDAHYALEDLSQSGYEVVGLDWTIRPQEARERTGKRVTLQGNMDPCALYASKVIQVWDLLSRMLGNWG 281
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Xenopus
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:496978])

HSP 1 Score: 286.574 bits (732), Expect = 3.099e-93
Identity = 148/265 (55.85%), Postives = 181/265 (68.30%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPII 887
            FP L ND  +R+A G     VPVW MRQAGRYLPEFR+ R   DFF  C++PE+ CE+TLQP+ RF LDAAIIF DILVIPQ               A+G  + M+PG+GPV P P+    DL+ L   VDV  +L YVF AI LTRHK+ G+ PLIGF G PWTLM YMIEGGGSNT SKAK+WLY     SH  L +LT +I ++L+ QV AGAQ LQVFESHAG L P QF++FSLPYLR+I+  +K ++    L D+VP++
Sbjct:   17 FPPLHNDTFLRAARGEECNHVPVWCMRQAGRYLPEFRETRAGQDFFASCRSPEICCELTLQPLRRFPLDAAIIFSDILVIPQ---------------ALGMEIRMEPGRGPVFPEPLQTPQDLHKLRSSVDVSEELGYVFRAITLTRHKIEGKVPLIGFTGAPWTLMTYMIEGGGSNTMSKAKRWLYQHPSASHQLLKQLTDVIVEYLVGQVAAGAQALQVFESHAGCLGPQQFSDFSLPYLRDISRRVKHKLKAEGL-DQVPMV 265
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Mouse
Match: Urod (uroporphyrinogen decarboxylase [Source:MGI Symbol;Acc:MGI:98916])

HSP 1 Score: 404.445 bits (1038), Expect = 1.120e-139
Identity = 198/373 (53.08%), Postives = 251/373 (67.29%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L        +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGG S+T ++AK+WLY     SH  L  LT ++  +L+ QV AGAQ LQ+FESHAG L  + F++F+LPY+R++A  +K  + K  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG Q+YIANLGHG+YPDMDP +V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGSSSTMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQALQLFESHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARERVGKAVTLQGNLDPCALYASEEEIGRLVQQMLDDFGPQRYIANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Mouse
Match: Urod (uroporphyrinogen decarboxylase [Source:MGI Symbol;Acc:MGI:98916])

HSP 1 Score: 76.6406 bits (187), Expect = 1.283e-16
Identity = 55/173 (31.79%), Postives = 73/173 (42.20%), Query Frame = 3 
Query:  399 VEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAI 917
            V M PGKGP  P P+ +  DL  L        +L YVF AI LTR +L GR PLIGFAG P                                                     QL +    H G    + F++F+LPY+R++A  +K  + K  L   VP+I+FAKD H+A+
Sbjct:    3 VTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPLIGFAGAP---------------------------------------------------ALQLFESHAGHLGT---ELFSKFALPYIRDVAKRVKAGLQKAGLAP-VPMIIFAKDGHFAL 120
[Close]
BLAST of uroporphyrinogen decarboxylase vs. UniProt/SwissProt
Match: sp|Q9PTS2|DCUP_DANRE (Uroporphyrinogen decarboxylase OS=Danio rerio OX=7955 GN=urod PE=2 SV=1)

HSP 1 Score: 426.017 bits (1094), Expect = 3.459e-147
Identity = 213/372 (57.26%), Postives = 259/372 (69.62%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMI 1205
            +FP L+ND  +R+A G  +E +PVW MRQAGRYLPEFR+ R   DFF  C++PE  CE+TLQP+ RF  DAAIIF DILV+PQ               A+G  V+M PGKGP  P P+ + +DL  L   VDV  +L YVF AI LTRHK+ G+ PLIGF G PWTLM+YMIEGGGS T SKAK+WLY     SH  LS+LT +I ++LL QVKAGAQ LQVFESH G L P +F EFSLPYLR+IA  +K +I +  L D VP+IVFAKD HY +EDLS+  Y+VV LDWTI PR AR   G  V+LQGN+DPCALY + E I    R+ML+ FG + YIANLGHG+YPDMDP  V  FV A+H  S +++
Sbjct:   12 DFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLPEFRESRAGKDFFETCRSPEACCELTLQPLRRFPFDAAIIFSDILVVPQ---------------AMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPLIGFTGAPWTLMSYMIEGGGSATHSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQALQVFESHTGCLGPVEFKEFSLPYLRDIARRVKDKIKESGL-DNVPMIVFAKDGHYGLEDLSESAYEVVGLDWTIDPRSARVRTGGKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEAVHNHSRQLL 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. UniProt/SwissProt
Match: sp|P70697|DCUP_MOUSE (Uroporphyrinogen decarboxylase OS=Mus musculus OX=10090 GN=Urod PE=1 SV=2)

HSP 1 Score: 404.445 bits (1038), Expect = 7.836e-139
Identity = 198/373 (53.08%), Postives = 251/373 (67.29%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L        +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGG S+T ++AK+WLY     SH  L  LT ++  +L+ QV AGAQ LQ+FESHAG L  + F++F+LPY+R++A  +K  + K  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG Q+YIANLGHG+YPDMDP +V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGSSSTMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQALQLFESHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARERVGKAVTLQGNLDPCALYASEEEIGRLVQQMLDDFGPQRYIANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. UniProt/SwissProt
Match: sp|Q8HY31|DCUP_SHEEP (Uroporphyrinogen decarboxylase OS=Ovis aries OX=9940 GN=UROD PE=1 SV=1)

HSP 1 Score: 404.445 bits (1038), Expect = 8.932e-139
Identity = 200/373 (53.62%), Postives = 250/373 (67.02%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T S+AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F++F+LPY+R+++  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P  AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG Q+YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREERDLERLRDPATVASELGYVFQAITLTRQQLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPEKARERVGKTVTLQGNLDPCALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. UniProt/SwissProt
Match: sp|Q5RDK5|DCUP_PONAB (Uroporphyrinogen decarboxylase OS=Pongo abelii OX=9601 GN=UROD PE=2 SV=1)

HSP 1 Score: 400.979 bits (1029), Expect = 1.954e-137
Identity = 199/373 (53.35%), Postives = 249/373 (66.76%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F++F+LPY+R++A  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG  +YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCEPTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREEQDLECLRDPEVVASELDYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQALQLFESHAGHLGPQLFSKFALPYIRDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. UniProt/SwissProt
Match: sp|P06132|DCUP_HUMAN (Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2)

HSP 1 Score: 400.979 bits (1029), Expect = 1.954e-137
Identity = 199/373 (53.35%), Postives = 249/373 (66.76%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            FP LKND  +R+A G   +  PVW MRQAGRYLPEFR+ R   DFF+ C++PE  CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+ +  DL  L     V  +L YVF AI LTR +L GR PLIGFAG PWTLM YM+EGGGS+T ++AK+WLY     SH  L  LT  +  +L+ QV AGAQ LQ+FESHAG L P  F +F+LPY+R++A  +K  + +  L   VP+I+FAKD H+A+E+L++  Y+VV LDWT+ P+ AR  VG  VTLQGNLDPCALY+S+E I    ++ML  FG  +YIANLGHG+YPDMDP  V  FV A+H  S  +  N
Sbjct:   11 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQ---------------ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367
[Close]
BLAST of uroporphyrinogen decarboxylase vs. TrEMBL
Match: A0A1S3K298 (uroporphyrinogen decarboxylase OS=Lingula unguis OX=7574 GN=LOC106178129 PE=3 SV=1)

HSP 1 Score: 437.573 bits (1124), Expect = 1.915e-149
Identity = 219/374 (58.56%), Postives = 276/374 (73.80%), Query Frame = 3 
Query:   81 SGDEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEM 1202
            +G  FP LKNDL++R+A G   E+VPVW MRQAGRYLPEF ++R ++DFF +CQTPELACEITLQPI R  LDAAIIF DILVIPQ               AVG  VEM PGKGP   +P+   DD+  L  DV+V   L YVF+AI LTRHKL G+ PLIGF+G PWTLM YMIEGGGSNT SKAKKWLY     SH  L  LT II ++L+ QV+AGAQ+LQ+FESHAG L P  F++F+LP ++ I+  +K E++ +  T  VP+I+FAKDAH+A+E+L +  Y+VV+LDWT+KP+HARR+   NVTLQGNLDPCALY+S+E I   T++ML+ FG QKYIANLGHG+YPD +P  +  F++++H  SE+M
Sbjct:    6 TGQAFPPLKNDLLLRAAAGEKTERVPVWAMRQAGRYLPEFHEVRSKHDFFEVCQTPELACEITLQPIRRLDLDAAIIFSDILVIPQ---------------AVGMKVEMVPGKGPTFDDPLKTPDDMKNLKKDVNVYETLNYVFEAITLTRHKLEGKVPLIGFSGAPWTLMAYMIEGGGSNTFSKAKKWLYVHPEESHQLLQLLTDIIVQYLVGQVQAGAQILQLFESHAGCLGPGNFSKFALPCIKQISKRVKEELS-VRGTKPVPMIIFAKDAHFALEELGESGYEVVALDWTVKPKHARRLA-PNVTLQGNLDPCALYASEEEISKMTKEMLKNFGTQKYIANLGHGMYPDHNPDHLAAFINSVHRHSEQM 362
[Close]
BLAST of uroporphyrinogen decarboxylase vs. TrEMBL
Match: A0A1S3IXY8 (uroporphyrinogen decarboxylase-like OS=Lingula unguis OX=7574 GN=LOC106168516 PE=3 SV=1)

HSP 1 Score: 436.417 bits (1121), Expect = 7.333e-149
Identity = 218/374 (58.29%), Postives = 275/374 (73.53%), Query Frame = 3 
Query:   81 SGDEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEM 1202
            +G  FP LKNDL++R+A G   E+VPVW MRQAGRYLPEF ++R ++DFF +CQTPELACEITLQPI R  LDAAIIF DILVIPQ               AVG  VEM PGKGP   +P+   DD+  L  DV+V   L YVF+AI LTRHKL G+ PLIGF+G PWTLM YMIEGGGSNT SKAKKWLY     SH  L  LT II ++L+ QV+AGAQ+LQ+FESHAG L P  F++F+LP ++ I+  +K E++   +   VP+I+FAKDAH+A+E+L +  Y+VV+LDWT+KP+HARR+   NVTLQGNLDPCALY+S+E I   T++ML+ FG QKYIANLGHG+YPD +P  +  F++++H  SE+M
Sbjct:    6 TGQAFPPLKNDLLLRAAAGEKTERVPVWAMRQAGRYLPEFHEVRSKHDFFEVCQTPELACEITLQPIRRLDLDAAIIFSDILVIPQ---------------AVGMKVEMVPGKGPTFDDPLKTPDDMKNLKKDVNVYETLNYVFEAITLTRHKLEGKVPLIGFSGAPWTLMAYMIEGGGSNTFSKAKKWLYVHPEESHQLLQLLTDIIVQYLVGQVQAGAQILQLFESHAGCLGPGNFSKFALPCIKQISKRIKEELSVRGIKP-VPMIIFAKDAHFALEELGESGYEVVALDWTVKPKHARRLA-PNVTLQGNLDPCALYASEEEISKMTKEMLKNFGTQKYIANLGHGMYPDHNPDHLAAFINSVHRHSEQM 362
[Close]
BLAST of uroporphyrinogen decarboxylase vs. TrEMBL
Match: G4VSS2 (Uroporphyrinogen decarboxylase OS=Schistosoma mansoni OX=6183 GN=Smp_143740 PE=3 SV=1)

HSP 1 Score: 434.876 bits (1117), Expect = 2.297e-148
Identity = 221/376 (58.78%), Postives = 274/376 (72.87%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEI-NKLNL-TDRVP-IIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMIT 1208
             FP LKND IIR+A G  V ++PVWIMRQAGRYLPEFR+LRE++DFF IC+TPELAC +TLQPINRF LDAAIIF DILVIPQ               A+G  V+MQPG GP    P+   +DL  L+  VDV  +L YV+++I LTR++LNGR PLIGFAG PWTLM+YMIEGG SNT SKAKKWLYT+   S   LS LT+ + + L++QV +GAQLLQVFESHAG LSP  F  F LPYL+ I+  +++ + N+  +  D +P +IVFAKD HYA+ +LSK DYDV+SLDWTI PR AR  VG+++TLQGNLDPCALYS++  I S  ++M+  FG  +YI NLGHGIYPD+DP KV  FV  +H +S  M+ 
Sbjct:    4 NFPTLKNDNIIRAAKGEAVSRLPVWIMRQAGRYLPEFRELREKHDFFEICRTPELACAVTLQPINRFDLDAAIIFSDILVIPQ---------------ALGMEVKMQPGVGPKFTEPLNSVNDLDRLNAQVDVRKELNYVYESITLTRYRLNGRVPLIGFAGAPWTLMSYMIEGGSSNTYSKAKKWLYTEPQSSQRLLSLLTQKVVEHLIQQVLSGAQLLQVFESHAGFLSPYLFNTFCLPYLKQISNEVRSRLLNEYRIPRDSIPPLIVFAKDGHYALTELSKADYDVISLDWTISPRLARNTVGSHITLQGNLDPCALYSNENQISSLVKEMINDFGIHRYIVNLGHGIYPDVDPDKVNKFVDLVHHLSSTMLN 364
[Close]
BLAST of uroporphyrinogen decarboxylase vs. TrEMBL
Match: A0A430QH89 (Uroporphyrinogen decarboxylase OS=Schistosoma bovis OX=6184 GN=DC041_0008361 PE=3 SV=1)

HSP 1 Score: 432.18 bits (1110), Expect = 2.487e-147
Identity = 220/377 (58.36%), Postives = 269/377 (71.35%), Query Frame = 3 
Query:   87 DEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEI-NKLNLTDRV--PIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMIT 1208
            + FP LKND IIR+A G  V ++PVWIMRQAGRYLPEFR+LRE++DFF IC+TPELAC +TLQPINRF LDAAIIF DILVIPQ               A+G  V+MQPG GP    P+   +DL  L+  VDV  +L YV+ +I LTRH+L G+ PLIGFAG PWTLM+YMIEGG SNT SK KKWLYT+   S   LS LT+II + L++Q  +GAQLLQVFESHAG LSP  F  F LPYL+ IA  +++ + N+  + +    P+IVFAKD HYA+ +LSK  YDV+SLDWTI PR AR  VG N+TLQGNLDPCALYS++  I S  ++M+  FG  +YI NLGHGIYPD+DP KV  FV  +H +S  M+ 
Sbjct:    3 NNFPTLKNDNIIRAAKGESVSRLPVWIMRQAGRYLPEFRELREKHDFFEICRTPELACAVTLQPINRFDLDAAIIFSDILVIPQ---------------ALGMEVKMQPGVGPKFTEPLNSVNDLDRLNAQVDVRKELDYVYKSITLTRHRLEGKVPLIGFAGAPWTLMSYMIEGGSSNTYSKPKKWLYTEPRSSQRLLSLLTQIIVEHLIQQFLSGAQLLQVFESHAGFLSPHLFNTFCLPYLKQIANEVRSRLLNEYKIPNDSIPPLIVFAKDGHYALTELSKSGYDVISLDWTISPRLARNTVGYNITLQGNLDPCALYSNENEISSLVKEMINNFGVHRYIVNLGHGIYPDVDPDKVNKFVDLVHQLSNTMLN 364
[Close]
BLAST of uroporphyrinogen decarboxylase vs. TrEMBL
Match: A0A183NZX4 (Uroporphyrinogen decarboxylase OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS7660 PE=3 SV=1)

HSP 1 Score: 430.639 bits (1106), Expect = 1.050e-146
Identity = 219/377 (58.09%), Postives = 270/377 (71.62%), Query Frame = 3 
Query:   87 DEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEI-NKLNLTDRV--PIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMIT 1208
            + FP LKND IIR+A G  V ++PVWIMRQAGRYLPEFR+LRE++DFF IC+TPELAC +TLQPI+RF LDAAIIF DILVIPQ               A+G  V+MQPG GP    P+   +DL  L+  VDV  +L YV+ +I LTRH+L G+ PLIGFAG PWTLM+YMIEGG SNT SK+KKWLYT+   S   LS LT+II + L++Q  +GAQLLQVFESHAG LSP  F  F LPYL+ IA  +++ + N+  + +    P+IVFAKD HYA+ +LSK  YDV+SLDWTI PR AR  VG N+TLQGNLDPCALYS++  I S  ++M+  FG  +YI NLGHGIYPD+DP KV  FV  +H +S  M+ 
Sbjct:    3 NNFPTLKNDNIIRAAKGESVSRLPVWIMRQAGRYLPEFRELREKHDFFEICRTPELACAVTLQPIHRFDLDAAIIFSDILVIPQ---------------ALGMEVKMQPGVGPKFTEPLNSVNDLDRLNAQVDVRKELDYVYKSITLTRHRLEGKVPLIGFAGAPWTLMSYMIEGGSSNTYSKSKKWLYTEPQSSQRLLSLLTQIIVEHLIQQFLSGAQLLQVFESHAGFLSPHLFNTFCLPYLKQIANEVRSRLLNEYKIPNDYIPPLIVFAKDGHYALTELSKSGYDVISLDWTISPRLARNTVGFNITLQGNLDPCALYSNENEISSLVKEMINNFGVHRYIVNLGHGIYPDVDPDKVNKFVDLVHQLSNTMLN 364
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Cavefish
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:103026230])

HSP 1 Score: 426.017 bits (1094), Expect = 2.988e-148
Identity = 214/380 (56.32%), Postives = 263/380 (69.21%), Query Frame = 3 
Query:   75 MISGDEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITNQ 1214
            +I   +FP LKND  +R+A G  VE VPVW MRQAGRYLPEFR+ R   DFF  C++PE  CE+TLQP+ RF  DA+IIF DILV+PQ               A+G  V+M PGKGP+ P P+ + DDL  L   VDV  +L YVF AI LTRHKL G+ PL+GF G PWTLM+YMIEGGGS T SKAK+WLY     SH  L +LT +I ++LL QVKAGAQ LQVFESH G L P +F EFSLPYLR+IA  +K ++ +  L D VP+IVFAKD HY +E+LS+  Y+VV LDWTI PR AR   G  V LQGN+DPCALY++ + I    +KM++ FG + YIANLGHG+YPDMDP  V  FV A+HT S ++I  +
Sbjct:    6 LIVPKDFPELKNDTFLRAARGEEVEHVPVWCMRQAGRYLPEFREARAGKDFFETCRSPEACCELTLQPLRRFPFDASIIFSDILVVPQ---------------AMGMDVQMCPGKGPIFPEPLKEPDDLQRLRPKVDVAAELGYVFKAITLTRHKLEGKVPLLGFTGAPWTLMSYMIEGGGSTTHSKAKRWLYRHPEASHKLLRQLTDVIVEYLLGQVKAGAQALQVFESHTGCLGPAEFKEFSLPYLRDIARRVKDKLKESGL-DNVPMIVFAKDGHYGLEELSQSHYEVVGLDWTIDPRSARERTGGKVCLQGNMDPCALYATKDRISEIVKKMVEGFGTKGYIANLGHGVYPDMDPECVGAFVDAVHTHSRQLINRK 369
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Sea Lamprey
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:30617])

HSP 1 Score: 167.162 bits (422), Expect = 8.339e-51
Identity = 92/164 (56.10%), Postives = 105/164 (64.02%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGP 581
            +FP LKND  +++A G   + VPVW MRQAGRYLPEFR+ R   DFF  CQ PEL C++TLQPI RF LDAAIIF DILV+PQ               A+G  V M PGKGP  P P+A   DL  L   VDV   L YVF AI LTRH+L GR PLIGF+G P
Sbjct:    2 KFPELKNDAFLKAARGEQTDFVPVWCMRQAGRYLPEFRETRAGQDFFETCQNPELCCKLTLQPIQRFALDAAIIFSDILVVPQ---------------AMGMEVVMTPGKGPTFPQPLADPADLSRLRERVDVHRHLGYVFRAITLTRHRLEGRVPLIGFSGAP 150
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Sea Lamprey
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:30617])

HSP 1 Score: 124.02 bits (310), Expect = 1.425e-34
Identity = 75/164 (45.73%), Postives = 87/164 (53.05%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGP 581
            +FP LKND  +++A G   + VPVW MRQAGRYLPEFR+ R   DFF  CQ PEL C++TLQ                                    A+G  V M PGKGP  P P+A   DL  L   VDV   L YVF AI LTRH+L GR PLIGF+G P
Sbjct:   10 KFPELKNDAFLKAARGEQTDFVPVWCMRQAGRYLPEFRETRAGQDFFETCQNPELCCKLTLQ------------------------------------AMGMEVVMTPGKGPTFPQPLADPADLSRLRERVDVHRHLGYVFRAITLTRHRLEGRVPLIGFSGAP 137
[Close]
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Yeast
Match: HEM12 (Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda [Source:SGD;Acc:S000002454])

HSP 1 Score: 332.028 bits (850), Expect = 2.656e-112
Identity = 178/374 (47.59%), Postives = 234/374 (62.57%), Query Frame = 3 
Query:   93 FPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQ--LDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIK-LKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQK--YIANLGHGIYPDMDPHKVETFVSAIHTISEE 1199
            FP  KNDLI+R+A G  VE+ P WIMRQAGRYLPE+ +++   DFF  C+  E+A EIT+QP+ R++  +DAAIIF DILVIPQ               A+G  VEM  GKGP  P P+   +DL  +       +K L + F AI +TR KL+G  PL GF GGPWTLM YM EGGGS     AK+W+     +SH  L K+T +  +FL +QV AGAQ+LQVFES  G LS   F EFSLPYLR IA  +   + +L + +++P+IVFAK + YA++ L    +DVVSLDW+  PR A ++    VTLQGNLDP  +Y S EVI  + ++M++ FG  K  YI N GHG +P MDP  ++ F+   H I  +
Sbjct:    4 FPAPKNDLILRAAKGEKVERPPCWIMRQAGRYLPEYHEVKNNRDFFQTCRDAEIASEITIQPVRRYRGLIDAAIIFSDILVIPQ---------------AMGMRVEMLEGKGPHFPEPLRNPEDLQTVLDYKVDVLKELDWAFKAITMTRIKLDGEVPLFGFCGGPWTLMVYMTEGGGSRLFRFAKQWINMYPELSHKLLQKITDVAVEFLSQQVVAGAQILQVFESWGGELSSVDFDEFSLPYLRQIAERVPKRLQELGIMEQIPMIVFAKGSWYALDKLCCSGFDVVSLDWSWDPREAVKINKNRVTLQGNLDPGVMYGSKEVITKKVKQMIEAFGGGKSRYIVNFGHGTHPFMDPDVIKFFLEECHRIGSK 362
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Nematostella
Match: EDO36098 (Uroporphyrinogen decarboxylase [Source:UniProtKB/TrEMBL;Acc:A7SJQ0])

HSP 1 Score: 400.208 bits (1027), Expect = 1.673e-138
Identity = 204/371 (54.99%), Postives = 256/371 (69.00%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQ--YDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISE 1196
            +FP L+ND I+R+A G  V++VPVW+MRQAGRYLPEFRK +E+   DFF I QTPE+ACE+TLQPI R+ LDAAIIF DILVIPQV               +G TVEM PGKGP  P P+    D+  L+ + ++   L YV+ AI LTRHKL G+ PL GF G PWTLM+YMIEGGGS   +K++KWLY     S   L  LT  + + L+ Q +AGAQ+LQVFESH G+L  D F  FSLPYLR IA  +K ++      D VP+ VFAK AHYAI++LS+  YDVVSLDWT+  + A R+V   VTLQGNLDP ALY S E IV   + M++ FG Q+YIANLGHG++PD DP K++TF+  +H+ SE
Sbjct:    9 DFPALQNDRILRAAKGESVDRVPVWVMRQAGRYLPEFRKFKEENGADFFKIVQTPEMACELTLQPIRRYDLDAAIIFSDILVIPQV---------------LGMTVEMVPGKGPHFPEPLNDPSDIEKLNQNANISEGLGYVYRAITLTRHKLEGKVPLFGFTGAPWTLMSYMIEGGGSTNFTKSRKWLYAHMEASSKLLQILTDAVVEHLVLQARAGAQILQVFESHGGLLGHDMFMLFSLPYLRQIAEKVKEKLG----PDAVPMTVFAKGAHYAIKELSQCGYDVVSLDWTMSSKEA-RIVAPTVTLQGNLDPAALYGSHEDIVYAVKGMVRGFGIQRYIANLGHGMHPDHDPDKLKTFIDTVHSYSE 359
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Nematostella
Match: EDO28859 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T5A4])

HSP 1 Score: 99.3673 bits (246), Expect = 8.425e-26
Identity = 48/90 (53.33%), Postives = 61/90 (67.78%), Query Frame = 3 
Query:  582 WTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEI 851
            WTLM+YMIEGGGS   +K++KWLY     S   L  LT  + + L+ Q +AGAQ+LQVFESH G+L  D F  FSLPYLR IA  +K ++
Sbjct:    1 WTLMSYMIEGGGSTNFTKSRKWLYAHMEASSKLLQILTDAVVEHLVLQARAGAQILQVFESHGGLLGHDMFMLFSLPYLRQIAEKVKEKL 90
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Medaka
Match: urod (uroporphyrinogen decarboxylase [Source:NCBI gene;Acc:101169315])

HSP 1 Score: 415.616 bits (1067), Expect = 3.886e-144
Identity = 212/374 (56.68%), Postives = 255/374 (68.18%), Query Frame = 3 
Query:   90 EFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITN 1211
            +FP LKND  +R+A G   E VPVW MRQAGRYLPEFR+ RE  DFF  C++PE+ CE+TLQP+ RF LDAAIIF DILV+PQ               A+G  V+M  GKGP    P+ + +DL  L   VDV+ +L YVF AI LTRHKL G+ PLIGF G PWTLM+YMIEGGGS T SKAK+WLY     SH  L  L  +I ++LL QV AGAQ LQVFESHAGIL P QF EFSLPYLR+IA  +K  + +      VP+IVFAKDAHY +EDLS+  Y+VV LDWTI P+ AR   G  V+LQGN+DPCALY+  E I    +KM+  FG + YIANLGHG+YPDM+P  V  FV A+H  S+ +I  
Sbjct:   11 DFPKLKNDTFLRAARGEDTEHVPVWCMRQAGRYLPEFREWREGKDFFETCRSPEICCELTLQPLRRFPLDAAIIFSDILVVPQ---------------AMGMNVQMLTGKGPTFTEPLKEPEDLERLQAKVDVQKELGYVFKAITLTRHKLEGKVPLIGFTGAPWTLMSYMIEGGGSVTQSKAKRWLYRHPEASHMLLKMLADVIVEYLLGQVTAGAQALQVFESHAGILGPAQFKEFSLPYLRDIARRVKDRLKEAG--QDVPMIVFAKDAHYGLEDLSESHYEVVGLDWTIDPQSARERTGGKVSLQGNMDPCALYAPKERISEIVKKMVAGFGTKGYIANLGHGLYPDMEPENVGAFVEAVHQHSKLLIKQ 367
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BLAST of uroporphyrinogen decarboxylase vs. Planmine SMEST
Match: SMESG000018128.1 (SMESG000018128.1)

HSP 1 Score: 714.146 bits (1842), Expect = 0.000e+0
Identity = 362/380 (95.26%), Postives = 363/380 (95.53%), Query Frame = 3 
Query:   75 MISGDEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQVFCNN*LA*LLF*F*AVGQTVEMQPGKGPVMPNPVAKFXXXXXXXXXXXXEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHTISEEMITNQ 1214
            MIS DEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQ               AVGQTVEMQPGKGPVMPNPVAKFDDLYLLDWDVDVEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLT IICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIH+ISEEMITNQ
Sbjct:    1 MISDDEFPVLKNDLIIRSALGHFVEKVPVWIMRQAGRYLPEFRKLREQYDFFTICQTPELACEITLQPINRFQLDAAIIFCDILVIPQ---------------AVGQTVEMQPGKGPVMPNPVAKFDDLYLLDWDVDVEIKLKYVFDAIRLTRHKLNGRCPLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTSIICKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEINKLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGANVTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPHKVETFVSAIHSISEEMITNQ 365
The following BLAST results are available for this feature:
BLAST of uroporphyrinogen decarboxylase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
UROD4.069e-13853.35uroporphyrinogen decarboxylase [Source:HGNC Symbol... [more]
UROD1.303e-12853.74uroporphyrinogen decarboxylase [Source:HGNC Symbol... [more]
UROD2.745e-12249.06uroporphyrinogen decarboxylase [Source:HGNC Symbol... [more]
UROD6.002e-11447.72uroporphyrinogen decarboxylase [Source:HGNC Symbol... [more]
UROD1.386e-10552.15uroporphyrinogen decarboxylase [Source:HGNC Symbol... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Updo1.002e-12451.89gene:FBgn0033428 transcript:FBtr0088524[more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
urod4.582e-14857.26uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
urod2.021e-14957.72uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
ENSXETT00000030380.11.767e-9954.43uroporphyrinogen decarboxylase-like [Source:NCBI g... [more]
urod3.099e-9355.85uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Urod1.120e-13953.08uroporphyrinogen decarboxylase [Source:MGI Symbol;... [more]
Urod1.283e-1631.79uroporphyrinogen decarboxylase [Source:MGI Symbol;... [more]
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BLAST of uroporphyrinogen decarboxylase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9PTS2|DCUP_DANRE3.459e-14757.26Uroporphyrinogen decarboxylase OS=Danio rerio OX=7... [more]
sp|P70697|DCUP_MOUSE7.836e-13953.08Uroporphyrinogen decarboxylase OS=Mus musculus OX=... [more]
sp|Q8HY31|DCUP_SHEEP8.932e-13953.62Uroporphyrinogen decarboxylase OS=Ovis aries OX=99... [more]
sp|Q5RDK5|DCUP_PONAB1.954e-13753.35Uroporphyrinogen decarboxylase OS=Pongo abelii OX=... [more]
sp|P06132|DCUP_HUMAN1.954e-13753.35Uroporphyrinogen decarboxylase OS=Homo sapiens OX=... [more]
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BLAST of uroporphyrinogen decarboxylase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3K2981.915e-14958.56uroporphyrinogen decarboxylase OS=Lingula unguis O... [more]
A0A1S3IXY87.333e-14958.29uroporphyrinogen decarboxylase-like OS=Lingula ung... [more]
G4VSS22.297e-14858.78Uroporphyrinogen decarboxylase OS=Schistosoma mans... [more]
A0A430QH892.487e-14758.36Uroporphyrinogen decarboxylase OS=Schistosoma bovi... [more]
A0A183NZX41.050e-14658.09Uroporphyrinogen decarboxylase OS=Schistosoma matt... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
urod2.988e-14856.32uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
urod8.339e-5156.10uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
urod1.425e-3445.73uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HEM122.656e-11247.59Uroporphyrinogen decarboxylase; catalyzes the fift... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO360981.673e-13854.99Uroporphyrinogen decarboxylase [Source:UniProtKB/... [more]
EDO288598.425e-2653.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
urod3.886e-14456.68uroporphyrinogen decarboxylase [Source:NCBI gene;A... [more]
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BLAST of uroporphyrinogen decarboxylase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000018128.10.000e+095.26SMESG000018128.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003163 ID=SMED30003163|Name=uroporphyrinogen decarboxylase|organism=Schmidtea mediterranea sexual|type=transcript|length=1255bp
GTTCACACTTTGTTTATTTAATCATTCAGTTATTTAAATTTTTTGATATT
GTAAAATTTATTTTTACTTATATTATGATTTCTGGCGATGAATTTCCTGT
TTTAAAAAATGATTTAATTATAAGAAGTGCATTAGGGCATTTCGTGGAAA
AGGTTCCTGTCTGGATAATGAGACAGGCTGGTAGGTATTTACCTGAATTT
CGAAAGCTAAGAGAACAATACGACTTTTTTACAATATGCCAAACGCCTGA
ATTAGCATGTGAGATAACTCTTCAACCTATTAATAGGTTTCAATTAGACG
CTGCAATTATATTTTGTGATATTTTAGTTATTCCTCAAGTTTTTTGTAAC
AATTAATTAGCATGATTATTATTTTAATTTTAGGCTGTTGGTCAAACAGT
TGAAATGCAACCGGGAAAGGGCCCAGTTATGCCAAATCCTGTTGCAAAAT
TTGATGACTTGTATCTACTTGATTGGGATGTTGATGTTGAAATAAAATTG
AAATATGTATTTGATGCTATTAGATTAACTAGGCATAAATTGAATGGACG
ATGCCCTTTAATCGGTTTTGCCGGAGGTCCATGGACATTAATGAATTATA
TGATAGAAGGCGGGGGTTCAAATACTGCTTCTAAAGCAAAAAAATGGCTT
TACACAGACAAAGTTATAAGTCACGATTTTCTTTCCAAACTAACTAGAAT
TATTTGCAAATTTTTACTAGAACAAGTTAAAGCTGGAGCACAATTATTGC
AGGTCTTTGAATCTCATGCTGGTATTTTGAGTCCTGATCAATTTGCGGAA
TTTAGTCTACCTTATCTCAGAAATATTGCCTTATTTCTGAAAACTGAAAT
TAATAAACTGAACCTAACTGATCGCGTGCCAATAATTGTTTTTGCAAAAG
ATGCTCATTATGCCATCGAAGATTTGTCAAAATTGGATTATGATGTAGTT
AGTTTAGATTGGACTATCAAACCTCGACACGCAAGGCGCATGGTTGGTGC
AAATGTCACGCTGCAGGGAAATTTGGATCCTTGCGCATTGTATAGTAGTG
ATGAGGTCATTGTTTCTGAAACTCGGAAGATGCTGCAGACATTTGGCTGT
CAAAAATACATTGCAAATTTAGGACATGGAATTTATCCAGATATGGATCC
GCATAAAGTTGAGACTTTTGTTTCAGCAATTCATACAATATCGGAGGAAA
TGATTACTAATCAATAGCTTTTTATTTAATATAATTTCAGTCTTTTCAAA
AAAAA
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protein sequence of SMED30003163-orf-1

>SMED30003163-orf-1 ID=SMED30003163-orf-1|Name=SMED30003163-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=271bp
MQPGKGPVMPNPVAKFDDLYLLDWDVDVEIKLKYVFDAIRLTRHKLNGRC
PLIGFAGGPWTLMNYMIEGGGSNTASKAKKWLYTDKVISHDFLSKLTRII
CKFLLEQVKAGAQLLQVFESHAGILSPDQFAEFSLPYLRNIALFLKTEIN
KLNLTDRVPIIVFAKDAHYAIEDLSKLDYDVVSLDWTIKPRHARRMVGAN
VTLQGNLDPCALYSSDEVIVSETRKMLQTFGCQKYIANLGHGIYPDMDPH
KVETFVSAIHTISEEMITNQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR000257Uroporphyrinogen_deCOase
Vocabulary: molecular function
TermDefinition
GO:0004853uroporphyrinogen decarboxylase activity
GO:0016829lyase activity
GO:0016831carboxy-lyase activity
Vocabulary: biological process
TermDefinition
GO:0006779porphyrin-containing compound biosynthetic process
GO:0006778porphyrin-containing compound metabolic process
GO:0006782protoporphyrinogen IX biosynthetic process
GO:0006783heme biosynthetic process
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005829cytosol