Tyrosine-protein kinase

Overview


Name	Tyrosine-protein kinase
Smed ID	SMED30003048
Length (bp)	2905

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Tyrosine-protein kinase (SMED30003048) t-SNE clustered cells

Violin plots show distribution of expression levels for Tyrosine-protein kinase (SMED30003048) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tyrosine-protein kinase (SMED30003048) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tyrosine-protein kinase (SMED30003048) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30003048

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
photoreceptor neuron	SMED30003048	h1SMcG0010071	SMED30003048	smed_20140614	PMID:22884275 Lapan et al., 2012

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Homology

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BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SYK (spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491])

HSP 1 Score: 276.944 bits (707), Expect = 4.716e-81
Identity = 118/224 (52.68%), Postives = 170/224 (75.89%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP FA + + +
Sbjct:  380 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 603

HSP 2 Score: 126.716 bits (317), Expect = 1.945e-29
Identity = 79/246 (32.11%), Postives = 130/246 (52.85%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR-PQGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252

HSP 3 Score: 68.9366 bits (167), Expect = 3.194e-11
Identity = 34/94 (36.17%), Postives = 53/94 (56.38%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLR-ESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHGKI+R+ +E +++      G FL+R    NG+Y + + H  KV HY I+K   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261

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Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP FA + + +
Sbjct:  380 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 603

HSP 2 Score: 126.716 bits (317), Expect = 1.945e-29
Identity = 79/246 (32.11%), Postives = 130/246 (52.85%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR-PQGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252

HSP 3 Score: 68.9366 bits (167), Expect = 3.194e-11
Identity = 34/94 (36.17%), Postives = 53/94 (56.38%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLR-ESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHGKI+R+ +E +++      G FL+R    NG+Y + + H  KV HY I+K   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261

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BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SYK (spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491])

HSP 1 Score: 276.559 bits (706), Expect = 8.691e-81
Identity = 118/224 (52.68%), Postives = 170/224 (75.89%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP FA + + +
Sbjct:  403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626

HSP 2 Score: 126.716 bits (317), Expect = 2.202e-29
Identity = 79/246 (32.11%), Postives = 130/246 (52.85%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR-PQGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252

HSP 3 Score: 68.9366 bits (167), Expect = 3.208e-11
Identity = 34/94 (36.17%), Postives = 53/94 (56.38%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLR-ESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHGKI+R+ +E +++      G FL+R    NG+Y + + H  KV HY I+K   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261

[Close]

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP FA + + +
Sbjct:  403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626

HSP 2 Score: 126.716 bits (317), Expect = 2.202e-29
Identity = 79/246 (32.11%), Postives = 130/246 (52.85%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR-PQGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252

HSP 3 Score: 68.9366 bits (167), Expect = 3.208e-11
Identity = 34/94 (36.17%), Postives = 53/94 (56.38%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLR-ESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHGKI+R+ +E +++      G FL+R    NG+Y + + H  KV HY I+K   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261

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BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: ZAP70 (zeta chain of T cell receptor associated protein kinase 70 [Source:HGNC Symbol;Acc:HGNC:12858])

HSP 1 Score: 256.144 bits (653), Expect = 4.441e-77
Identity = 120/242 (49.59%), Postives = 167/242 (69.01%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYL-RRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGI 2350
            I VA+K+LK+    K    E+M EA+ M QL + +IVRLIGVC+ E ++L++E+A  GP++K+L  + + +   ++ EL+ QVS GM YLE   FVHRDLAARNVLLVN HYAKISDFG+SKAL     YY A +AGKWPLKWYAPECI + +F S+SDVWSYG+T+WE  SYG++PYK +KG ++++ ++QG+R++ P  CP  +Y +M  CW      RP F  +   M      L++ +
Sbjct:   57 IDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKV 297

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: ark-1 (Ack-related non-receptor tyrosine kinase [Source:UniProtKB/Swiss-Prot;Acc:G5EBZ8])

HSP 1 Score: 202.216 bits (513), Expect = 3.860e-53
Identity = 95/214 (44.39%), Postives = 142/214 (66.36%), Query Frame = 2

Query: 1688 IMEEARTMSQLRHKHIVRLIGVC-KCEQILLILELAPLGPINKYLRR---NQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAG--KWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQR-LKKPINCPESIYDVMLQCWSTDGVRRPTFAELV 2308
             ++EA  M+++RH+H+VRL GV    ++I+L+ ELA  G + + L +     S     L +   Q++ GM+YLE  + +HRDLAARNVL+ +    KISDFG+S++L  G+DYYR+      K P+ W APECI + +F SKSDVW+YG+T+WE+FSYGE P+K   G QIL ++D+ +  L +P  CPE IYD++ + W+     RPTF+++V
Sbjct:  160 FLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIV 373

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: ark-1 (Ack-related non-receptor tyrosine kinase [Source:UniProtKB/Swiss-Prot;Acc:G5EBZ8])

HSP 1 Score: 201.83 bits (512), Expect = 4.390e-53
Identity = 95/214 (44.39%), Postives = 142/214 (66.36%), Query Frame = 2

Query: 1688 IMEEARTMSQLRHKHIVRLIGVC-KCEQILLILELAPLGPINKYLRR---NQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAG--KWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQR-LKKPINCPESIYDVMLQCWSTDGVRRPTFAELV 2308
             ++EA  M+++RH+H+VRL GV    ++I+L+ ELA  G + + L +     S     L +   Q++ GM+YLE  + +HRDLAARNVL+ +    KISDFG+S++L  G+DYYR+      K P+ W APECI + +F SKSDVW+YG+T+WE+FSYGE P+K   G QIL ++D+ +  L +P  CPE IYD++ + W+     RPTF+++V
Sbjct:  160 FLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIV 373

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-2 (Tyrosine protein-kinase src-2 [Source:UniProtKB/Swiss-Prot;Acc:O45539])

HSP 1 Score: 187.193 bits (474), Expect = 1.254e-50
Identity = 93/227 (40.97%), Postives = 136/227 (59.91%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVC-KCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            +PVAVK LK          + + EA+ M +LRH  ++ L  VC + E IL++ EL     +    RR +      L+E+ +QV+ GMAYLE   F+HRDLAARN+L+ N    KI+DFG+++ L   ++ Y A    ++P+KW APE   Y RF +KSDVWS+GI L E+ ++G  PY  +   ++L  +D G R+  P  CP ++YD+M QCW +D  +RPTF  L
Sbjct:  263 VPVAVKKLKA---GTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQENLLTFLQRRGRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARIL-MKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETL 485

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: abl-1 (Tyrosine-protein kinase abl-1 [Source:UniProtKB/Swiss-Prot;Acc:P03949])

HSP 1 Score: 193.356 bits (490), Expect = 3.754e-50
Identity = 94/234 (40.17%), Postives = 143/234 (61.11%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLRRNQS--LSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            +AVK LK++    +  HE + EA  M  L HK++VRL+GVC  E    +I E    G + +YLRR     L    L+++ SQ++ GM+YLEA  F+HRDLAARN L+   +  KI+DFG+++ +   +D Y A A  K+P+KW APE + +  F SKSDVW++G+ LWE+ +YG  PY  ++ + +  +L+ G R+  P  CP S+Y +MLQCW+     RP F ++   +  +
Sbjct:  337 IAVKALKEDA---MPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMK--EDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENL 565

HSP 2 Score: 61.6178 bits (148), Expect = 2.869e-9
Identity = 42/115 (36.52%), Postives = 57/115 (49.57%), Query Frame = 2

Query:   65 SPFNIL----YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYIL 391
            +P+N L    ++HGKI+R  +E +L S   I G FL+RES    G Y IS+ H  +V HY I   +     I    KF    ELV HH +H DG + L   P  +   G   + L
Sbjct:  184 APYNSLDKYTWYHGKISRSDSEAILGS--GITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSL 296

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: abl-1 (Tyrosine-protein kinase abl-1 [Source:UniProtKB/Swiss-Prot;Acc:P03949])

HSP 1 Score: 193.356 bits (490), Expect = 4.187e-50
Identity = 94/234 (40.17%), Postives = 143/234 (61.11%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLRRNQS--LSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            +AVK LK++    +  HE + EA  M  L HK++VRL+GVC  E    +I E    G + +YLRR     L    L+++ SQ++ GM+YLEA  F+HRDLAARN L+   +  KI+DFG+++ +   +D Y A A  K+P+KW APE + +  F SKSDVW++G+ LWE+ +YG  PY  ++ + +  +L+ G R+  P  CP S+Y +MLQCW+     RP F ++   +  +
Sbjct:  327 IAVKALKEDA---MPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMK--EDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENL 555

HSP 2 Score: 61.6178 bits (148), Expect = 2.721e-9
Identity = 42/115 (36.52%), Postives = 57/115 (49.57%), Query Frame = 2

Query:   65 SPFNIL----YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYIL 391
            +P+N L    ++HGKI+R  +E +L S   I G FL+RES    G Y IS+ H  +V HY I   +     I    KF    ELV HH +H DG + L   P  +   G   + L
Sbjct:  174 APYNSLDKYTWYHGKISRSDSEAILGS--GITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSL 286

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Shark (gene:FBgn0015295 transcript:FBtr0087244)

HSP 1 Score: 213.001 bits (541), Expect = 9.025e-57
Identity = 104/232 (44.83%), Postives = 143/232 (61.64%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKY-LRRNQSLSEQSLIEL-MSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSR 2323
            VA+KML  E  +K    E + EA  M +L HK IVRLIG+ K E ++++ ELAPLG + +Y L     ++  + +++  SQ++ GM YLE+  FVHRDLAARN+LL   H AKISDFGMS++L  G   Y+    G+WP++WYAPE      F   SDVWS+G+T+WE+FS G  PY ++     + ++D G+RL +P  CP  IY VM  CW      RPTF  L    +R
Sbjct:  695 VAIKMLSDEHSNK---QEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFAR 923

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src42A (gene:FBgn0264959 transcript:FBtr0335275)

HSP 1 Score: 195.282 bits (495), Expect = 3.592e-53
Identity = 94/232 (40.52%), Postives = 148/232 (63.79%), Query Frame = 2

Query: 1625 TIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLR----RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            T PVA+K LK      +   + + EA+ M +LRH  +++L  VC  E+ I +I EL   G + +YL+    + +SL  Q+LI++ +Q++ GMAYLE+  ++HRDLAARNVL+ + +  KI+DFG+++ +   +D Y A    ++P+KW APE   Y +F  KSDVWS+GI L E+ +YG  PY  +   ++L+ ++ G R+ +P NC   +Y++ML+CW  D +RRPTF  L
Sbjct:  270 TTPVAIKTLKS---GTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK--EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 496

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src42A (gene:FBgn0264959 transcript:FBtr0335276)

HSP 1 Score: 199.134 bits (505), Expect = 8.851e-52
Identity = 94/232 (40.52%), Postives = 148/232 (63.79%), Query Frame = 2

Query: 1625 TIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLR----RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            T PVA+K LK      +   + + EA+ M +LRH  +++L  VC  E+ I +I EL   G + +YL+    + +SL  Q+LI++ +Q++ GMAYLE+  ++HRDLAARNVL+ + +  KI+DFG+++ +   +D Y A    ++P+KW APE   Y +F  KSDVWS+GI L E+ +YG  PY  +   ++L+ ++ G R+ +P NC   +Y++ML+CW  D +RRPTF  L
Sbjct: 1350 TTPVAIKTLKS---GTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK--EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 1576

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Ack-like (gene:FBgn0263998 transcript:FBtr0330329)

HSP 1 Score: 196.438 bits (498), Expect = 6.015e-51
Identity = 104/241 (43.15%), Postives = 147/241 (61.00%), Query Frame = 2

Query: 1613 NLLETIPVAVKMLKKE-MHSKIGAHEIMEEARTMSQLRHKHIVRLIGVC-KCEQILLILELAPLGPINKYLR----RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAA--AAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQG--QRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            N  E I VA+K L +E M S     E ++EA  M  + H++IVRL GV    + ++L+ ELA L  + + L+    R   L+  +L E   Q+  GM YLE  + +HRDLAARN+L+ ++   KISDFG+S+AL  G+DYY+       K P+ W APECI Y RF + SDVW++G+ LWE+FSYG +P+  L G QIL  +D    QRL++P  CP   Y +M++CW  D  +RP F E+
Sbjct:  154 NGNERIQVAIKCLCRERMQSN--PMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Ack-like (gene:FBgn0263998 transcript:FBtr0330331)

HSP 1 Score: 196.438 bits (498), Expect = 6.074e-51
Identity = 104/241 (43.15%), Postives = 147/241 (61.00%), Query Frame = 2

Query: 1613 NLLETIPVAVKMLKKE-MHSKIGAHEIMEEARTMSQLRHKHIVRLIGVC-KCEQILLILELAPLGPINKYLR----RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAA--AAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQG--QRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            N  E I VA+K L +E M S     E ++EA  M  + H++IVRL GV    + ++L+ ELA L  + + L+    R   L+  +L E   Q+  GM YLE  + +HRDLAARN+L+ ++   KISDFG+S+AL  G+DYY+       K P+ W APECI Y RF + SDVW++G+ LWE+FSYG +P+  L G QIL  +D    QRL++P  CP   Y +M++CW  D  +RP F E+
Sbjct:  154 NGNERIQVAIKCLCRERMQSN--PMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392

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BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: syk (spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040702-3])

HSP 1 Score: 276.944 bits (707), Expect = 1.559e-81
Identity = 118/222 (53.15%), Postives = 168/222 (75.68%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            VAVK+LK +  +     E++ EA  M QL + +IVR+IG+C+ E ++L++ELA LGP++K+L++N+ ++ ++L EL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWPLKWYAPEC+ Y +F SKSDVWS+G+ +WE FSYG++PYK +KG +++ M++ GQR+  P +CP  +YD+M +CW+     RP F+
Sbjct:  349 VAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKNKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFS 570

HSP 2 Score: 116.316 bits (290), Expect = 2.004e-26
Identity = 77/245 (31.43%), Postives = 131/245 (53.47%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKG---DCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            YF G ITR+ +E  L   G+ +G++LLR+S +  G Y +S+ +  +  HY IE++ + T+ I  G+    PI+++ +H    DG + L + P  R P GT   +  G      E  I++   +      S++++ +    R  L+ ++    H   PWFH  + R ++E RL N     G+FL+RQR+    +  + L +   NQ  HY+I  ++  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   10 YFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHR-PRGTEPKV--GPFEDLKEQLIRQYVEQTWNLKGSALDQAIIS-QRPQLEKLIATTAHEKMPWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALCLLHNNQVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLL 250

[Close]

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            VAVK+LK +  +     E++ EA  M QL + +IVR+IG+C+ E ++L++ELA LGP++K+L++N+ ++ ++L EL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWPLKWYAPEC+ Y +F SKSDVWS+G+ +WE FSYG++PYK +KG +++ M++ GQR+  P +CP  +YD+M +CW+     RP F+
Sbjct:  349 VAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKNKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFS 570

HSP 2 Score: 116.316 bits (290), Expect = 2.004e-26
Identity = 77/245 (31.43%), Postives = 131/245 (53.47%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKG---DCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            YF G ITR+ +E  L   G+ +G++LLR+S +  G Y +S+ +  +  HY IE++ + T+ I  G+    PI+++ +H    DG + L + P  R P GT   +  G      E  I++   +      S++++ +    R  L+ ++    H   PWFH  + R ++E RL N     G+FL+RQR+    +  + L +   NQ  HY+I  ++  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   10 YFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHR-PRGTEPKV--GPFEDLKEQLIRQYVEQTWNLKGSALDQAIIS-QRPQLEKLIATTAHEKMPWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALCLLHNNQVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLL 250

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: syk (spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040702-3])

HSP 1 Score: 276.944 bits (707), Expect = 2.645e-81
Identity = 118/222 (53.15%), Postives = 168/222 (75.68%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            VAVK+LK +  +     E++ EA  M QL + +IVR+IG+C+ E ++L++ELA LGP++K+L++N+ ++ ++L EL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWPLKWYAPEC+ Y +F SKSDVWS+G+ +WE FSYG++PYK +KG +++ M++ GQR+  P +CP  +YD+M +CW+     RP F+
Sbjct:  372 VAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKNKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFS 593

HSP 2 Score: 116.316 bits (290), Expect = 2.241e-26
Identity = 77/245 (31.43%), Postives = 131/245 (53.47%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKG---DCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            YF G ITR+ +E  L   G+ +G++LLR+S +  G Y +S+ +  +  HY IE++ + T+ I  G+    PI+++ +H    DG + L + P  R P GT   +  G      E  I++   +      S++++ +    R  L+ ++    H   PWFH  + R ++E RL N     G+FL+RQR+    +  + L +   NQ  HY+I  ++  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   10 YFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHR-PRGTEPKV--GPFEDLKEQLIRQYVEQTWNLKGSALDQAIIS-QRPQLEKLIATTAHEKMPWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALCLLHNNQVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLL 250

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: zap70 (zeta chain of T cell receptor associated protein kinase 70 [Source:ZFIN;Acc:ZDB-GENE-050522-257])

HSP 1 Score: 264.618 bits (675), Expect = 7.324e-77
Identity = 123/258 (47.67%), Postives = 175/258 (67.83%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLR-RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGS 2398
            I VA+K+LK E    +   E+M EA  M QL    IVR+IG+C+ E ++L++E+AP GP+NK+L  +   ++ ++++ LM QVS GM YLE   FVHRDLAARNVLLVN+ YAKISDFG+SKAL    +YY+A   GKWPLKWYAPECI++ +F SKSDVWS+GIT+WE FS+G +PYK +KG ++++ ++ G RL  P  CPE++Y++M +CW+     R  FA++   M      ++  I       +YL   +G+
Sbjct:  351 IDVAIKVLKNENEKSV-RDEMMREAEIMHQLSDPFIVRMIGLCEAEALMLVMEMAPAGPLNKFLSGKKDQITTENIVMLMHQVSMGMKYLEGRNFVHRDLAARNVLLVNQQYAKISDFGLSKALGADDNYYKARTGGKWPLKWYAPECIHFHKFSSKSDVWSFGITMWEAFSFGGKPYKKMKGPEVITYIEGGSRLDCPAACPEAMYELMKECWTYKHEERLNFAKVEEKMRTFYYSIAKKI------PDYLKTENGT 601

HSP 2 Score: 111.694 bits (278), Expect = 6.481e-25
Identity = 77/249 (30.92%), Postives = 131/249 (52.61%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLR 811
            ++ +F+G I+R  AE+ L   G  +G+FLLR+ +   G YV+S+       HY+IEKQ +GT+ I  G+   GP EL E++    DG +   R P  R P      I +GV  +  ++ +++        +  ++E+ +     Q L+ ++    H   PWFH  + R E E RL +    +G+FLVR+R     F LS++      HY+I+ +K  K+ +  G  FD++ +L+++   + DGL+  LR
Sbjct:    7 DLPFFYGSISRSEAEEHLKLAGMGDGLFLLRQCLRSLGGYVLSMIWNLDFYHYSIEKQLNGTYCIAGGKPHCGPAELCEYYSKDPDGLVCTLRKPCLRSPETE---IRKGVFDNLRDNMLREYVRHTWKLEGDAMEQAIISQAPQ-LEKLIATTAHEKMPWFHGKIPRQEGERRLYSGSQPDGKFLVRERDEMGTFALSVTYGKTVYHYQILRDKSGKIAMPEGTKFDTVWQLVEYLKMKPDGLVTVLR 251

HSP 3 Score: 57.3806 bits (137), Expect = 7.999e-8
Identity = 32/91 (35.16%), Postives = 46/91 (50.55%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN-GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLP 352
            +FHGKI R   E  L S    +G FL+RE    G + +S+ +   V HY I +   G   +  G KF    +LVE+  +  DG +T+ R P
Sbjct:  163 WFHGKIPRQEGERRLYSGSQPDGKFLVRERDEMGTFALSVTYGKTVYHYQILRDKSGKIAMPEGTKFDTVWQLVEYLKMKPDGLVTVLREP 253

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64])

HSP 1 Score: 205.297 bits (521), Expect = 3.720e-55
Identity = 98/234 (41.88%), Postives = 149/234 (63.68%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQ-SLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            IPVA+K+L +    K    E M+EA  M+ + H H+VRL+GVC    I L+ +L P G +  Y+  +Q ++  Q L+    Q+++GM YLE  + VHRDLAARNVL+ + ++ KI+DFG+++ L   +  Y +A  GK P+KW A ECI+Y +F  +SDVWSYG+T+WE+ ++G +PY  +   +I  +L++G+RL +P  C   +Y VM++CW  D   RP F EL    SR+
Sbjct:   53 IPVAIKILNESTGPKANV-EFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEY-SADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRM 284

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: zap70 (zeta chain of T cell receptor associated protein kinase 70 [Source:NCBI gene;Acc:448557])

HSP 1 Score: 264.618 bits (675), Expect = 9.875e-77
Identity = 123/224 (54.91%), Postives = 163/224 (72.77%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQS-LIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTF 2296
            I VA+K+LK +    +   E+M+EA  M QL + +IVR+IGVC+ E ++L++E+A  GP+NK+L   + +   S ++ELM QVS GM YLE   FVHRDLAARNVL+VN+HYAKISDFG+SKAL     YY+A + GKWPLKWYAPECI Y +F S+SDVWSYGIT+WE F+YG++PYK LKGT+++S +++ +RL  P  CP  +Y VML CW      RP F
Sbjct:  352 IDVAIKVLKVQDEKNV-RDEMMKEAEIMHQLDNPYIVRMIGVCEAENLMLVMEMASGGPLNKFLGAKKDVIPMSNIVELMHQVSIGMKYLEGKNFVHRDLAARNVLMVNQHYAKISDFGLSKALAADDSYYKAKSFGKWPLKWYAPECINYRKFSSRSDVWSYGITMWEAFTYGQKPYKKLKGTEVMSFIERNERLACPAGCPPEMYQVMLDCWIFKMEDRPNF 574

HSP 2 Score: 109.768 bits (273), Expect = 4.507e-24
Identity = 74/252 (29.37%), Postives = 132/252 (52.38%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECP 829
            +++G I+R  AE+ L   G ++G+FLLR+ +   G YV+S+ +    +HY +E+Q +GT+ I  G+   GP EL E++    DG     R P  R PAG       GV  +  ++ +++   +    +  ++E+ +     Q ++ ++    H    W+H  + R EAE +L +    +G+FL+R+RK +  + LS+       HYKI  +K  K  I  G  FD+L +L+++   + DG++  L+    CP
Sbjct:   10 FYYGSISRADAEEYLKLGGMMDGLFLLRQCLRTLGGYVLSMVYNLHFHHYPVERQLNGTYAIAGGKAHCGPAELCEYYSKDADGLCCTLRRPCNR-PAGVE--CQAGVFDNMRDNMMREYVRQTWKLEGDALEQAIISQAPQ-VEKLIATTAHERMAWYHGTISRDEAERKLYSGAQPDGKFLMRERKENGTYALSVMYGKTVYHYKIDQDKSGKYSIPEGTKFDTLWQLVEYLKLKSDGIMAVLK--ESCP 255

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: galk1 (galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127])

HSP 1 Score: 262.307 bits (669), Expect = 2.217e-76
Identity = 113/223 (50.67%), Postives = 167/223 (74.89%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + + +    E+++EA+ M  L + +IVR++G+C+ E  +L++ELA LGP+NK+L +N++++E ++ EL+ QVS GM YLE + FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A  AGKWP+KWYAPE + Y +F SKSDVWS+G+ +WE +SYG +PY  +KG ++ + ++ G RL+ P  CP  +Y+++  CW+     RP+FA
Sbjct:  325 PVAVKILKNDSNDESMKDELLKEAKVMQLLNNPYIVRMLGICEGESWMLVMELAGLGPLNKFLVKNKNVTEHNVTELVHQVSMGMKYLEETNFVHRDLAARNVLLVTQHYAKISDFGLSKALESDENYYQAKTAGKWPMKWYAPESLNYHKFSSKSDVWSFGVLMWEAYSYGLKPYPGMKGNEVTAFIESGNRLECPRRCPAEMYNLIKLCWTYKTEERPSFA 547

HSP 2 Score: 122.094 bits (305), Expect = 3.691e-28
Identity = 80/251 (31.87%), Postives = 130/251 (51.79%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGV--KSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            N+ YF G ITR+ +ED L   GA +G++LLR+S +  G Y +S+ H     HY IE++ +GT+ I  G     P EL  +H L   G + L + P  R P         GV  K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R ++E+ L +   + G FL+R+R  +  + L +    +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:    7 NLPYFFGNITREESEDYLRQAGAADGLYLLRQSRSYLGGYALSVAHGRHFYHYTIERELNGTYAISGGISHSSPAELCHYHTLESSGLVCLLKKPCNRLP---------GVQPKTGPFEDLKEHLIREYVHQTWNLQGEALEQAIIS-QKPQLEKLIATTAHEKMPWFHGRISREDSEQLLISGVKSNGSFLIRERDDNGSYALCLLHDRKISHYRIDRDKTGKLSIPDGKKFDTLWQLVEHYSYKPDGLL 247

HSP 3 Score: 69.707 bits (169), Expect = 1.401e-11
Identity = 36/94 (38.30%), Postives = 54/94 (57.45%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG+I+R+ +E LL+S     G FL+RE   NG+Y + + H  K++HY I++   G   I  G+KF    +LVEH+    DG L +   P  R
Sbjct:  163 WFHGRISREDSEQLLISGVKSNGSFLIRERDDNGSYALCLLHDRKISHYRIDRDKTGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTEPCPR 256

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: galk1 (galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127])

HSP 1 Score: 262.307 bits (669), Expect = 2.220e-76
Identity = 113/223 (50.67%), Postives = 167/223 (74.89%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + + +    E+++EA+ M  L + +IVR++G+C+ E  +L++ELA LGP+NK+L +N++++E ++ EL+ QVS GM YLE + FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A  AGKWP+KWYAPE + Y +F SKSDVWS+G+ +WE +SYG +PY  +KG ++ + ++ G RL+ P  CP  +Y+++  CW+     RP+FA
Sbjct:  304 PVAVKILKNDSNDESMKDELLKEAKVMQLLNNPYIVRMLGICEGESWMLVMELAGLGPLNKFLVKNKNVTEHNVTELVHQVSMGMKYLEETNFVHRDLAARNVLLVTQHYAKISDFGLSKALESDENYYQAKTAGKWPMKWYAPESLNYHKFSSKSDVWSFGVLMWEAYSYGLKPYPGMKGNEVTAFIESGNRLECPRRCPAEMYNLIKLCWTYKTEERPSFA 526

HSP 2 Score: 124.02 bits (310), Expect = 8.109e-29
Identity = 93/308 (30.19%), Postives = 150/308 (48.70%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGV--KSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVE--SAHSTICGMQNAARIQRTAVKTDLSR 964
            N+ YF G ITR+ +ED L   GA +G++LLR+S +  G Y +S+ H     HY IE++ +GT+ I  G     P EL  +H L   G + L + P  R P         GV  K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R ++E+ L +   + G FL+R+R  +  + L +    +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL  L     CP       EF     + S E  +   T  G  N   +++  +KT  S+
Sbjct:    7 NLPYFFGNITREESEDYLRQAGAADGLYLLRQSRSYLGGYALSVAHGRHFYHYTIERELNGTYAISGGISHSSPAELCHYHTLESSGLVCLLKKPCNRLP---------GVQPKTGPFEDLKEHLIREYVHQTWNLQGEALEQAIIS-QKPQLEKLIATTAHEKMPWFHGRISREDSEQLLISGVKSNGSFLIRERDDNGSYALCLLHDRKISHYRIDRDKTGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLT--EPCPRATGHSDEFRPMDGKISREQLTLFETELGSGNFGNVKKGELKTSKSK 302

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: galk1 (galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127])

HSP 1 Score: 262.692 bits (670), Expect = 5.654e-76
Identity = 113/223 (50.67%), Postives = 167/223 (74.89%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + + +    E+++EA+ M  L + +IVR++G+C+ E  +L++ELA LGP+NK+L +N++++E ++ EL+ QVS GM YLE + FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A  AGKWP+KWYAPE + Y +F SKSDVWS+G+ +WE +SYG +PY  +KG ++ + ++ G RL+ P  CP  +Y+++  CW+     RP+FA
Sbjct:  374 PVAVKILKNDSNDESMKDELLKEAKVMQLLNNPYIVRMLGICEGESWMLVMELAGLGPLNKFLVKNKNVTEHNVTELVHQVSMGMKYLEETNFVHRDLAARNVLLVTQHYAKISDFGLSKALESDENYYQAKTAGKWPMKWYAPESLNYHKFSSKSDVWSFGVLMWEAYSYGLKPYPGMKGNEVTAFIESGNRLECPRRCPAEMYNLIKLCWTYKTEERPSFA 596

HSP 2 Score: 122.865 bits (307), Expect = 2.746e-28
Identity = 80/251 (31.87%), Postives = 130/251 (51.79%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGV--KSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            N+ YF G ITR+ +ED L   GA +G++LLR+S +  G Y +S+ H     HY IE++ +GT+ I  G     P EL  +H L   G + L + P  R P         GV  K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R ++E+ L +   + G FL+R+R  +  + L +    +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:    7 NLPYFFGNITREESEDYLRQAGAADGLYLLRQSRSYLGGYALSVAHGRHFYHYTIERELNGTYAISGGISHSSPAELCHYHTLESSGLVCLLKKPCNRLP---------GVQPKTGPFEDLKEHLIREYVHQTWNLQGEALEQAIIS-QKPQLEKLIATTAHEKMPWFHGRISREDSEQLLISGVKSNGSFLIRERDDNGSYALCLLHDRKISHYRIDRDKTGKLSIPDGKKFDTLWQLVEHYSYKPDGLL 247

HSP 3 Score: 70.8626 bits (172), Expect = 6.468e-12
Identity = 37/105 (35.24%), Postives = 58/105 (55.24%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQ 394
            +FHG+I+R+ +E LL+S     G FL+RE   NG+Y + + H  K++HY I++   G   I  G+KF    +LVEH+    DG L +   P  R    +  +I +
Sbjct:  163 WFHGRISREDSEQLLISGVKSNGSFLIRERDDNGSYALCLLHDRKISHYRIDRDKTGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTEPCPRATGHSESFIFK 267

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: galk1 (galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127])

HSP 1 Score: 261.922 bits (668), Expect = 7.621e-76
Identity = 113/223 (50.67%), Postives = 167/223 (74.89%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + + +    E+++EA+ M  L + +IVR++G+C+ E  +L++ELA LGP+NK+L +N++++E ++ EL+ QVS GM YLE + FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A  AGKWP+KWYAPE + Y +F SKSDVWS+G+ +WE +SYG +PY  +KG ++ + ++ G RL+ P  CP  +Y+++  CW+     RP+FA
Sbjct:  366 PVAVKILKNDSNDESMKDELLKEAKVMQLLNNPYIVRMLGICEGESWMLVMELAGLGPLNKFLVKNKNVTEHNVTELVHQVSMGMKYLEETNFVHRDLAARNVLLVTQHYAKISDFGLSKALESDENYYQAKTAGKWPMKWYAPESLNYHKFSSKSDVWSFGVLMWEAYSYGLKPYPGMKGNEVTAFIESGNRLECPRRCPAEMYNLIKLCWTYKTEERPSFA 588

HSP 2 Score: 122.479 bits (306), Expect = 3.526e-28
Identity = 96/326 (29.45%), Postives = 156/326 (47.85%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGV--KSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIE-CPG---------FIRSKAEFLQSLNQSSVESAHSTICGMQ-NAARIQRTAVKTDLSRIVTDKYRDM 991
            N+ YF G ITR+ +ED L   GA +G++LLR+S +  G Y +S+ H     HY IE++ +GT+ I  G     P EL  +H L   G + L + P  R P         GV  K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R ++E+ L +   + G FL+R+R  +  + L +    +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGL   LR   E CP          F R+      + +Q    +  ++IC +Q +        V  D   + TD YR +
Sbjct:    7 NLPYFFGNITREESEDYLRQAGAADGLYLLRQSRSYLGGYALSVAHGRHFYHYTIERELNGTYAISGGISHSSPAELCHYHTLESSGLVCLLKKPCNRLP---------GVQPKTGPFEDLKEHLIREYVHQTWNLQGEALEQAIIS-QKPQLEKLIATTAHEKMPWFHGRISREDSEQLLISGVKSNGSFLIRERDDNGSYALCLLHDRKISHYRIDRDKTGKLSIPDGKKFDTLWQLVEHYSYKPDGL---LRVLTEPCPRATGHSESFIFKRAPCPAPPTQHQMVSNACITSICSLQHHKGHSLLVKVTMDSMPMDTDVYRGI 319

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Syk (spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515])

HSP 1 Score: 275.018 bits (702), Expect = 2.012e-80
Identity = 117/224 (52.23%), Postives = 169/224 (75.45%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP F  + + +
Sbjct:  397 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL 620

HSP 2 Score: 128.642 bits (322), Expect = 3.353e-30
Identity = 80/249 (32.13%), Postives = 131/249 (52.61%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            ++ YF G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R     + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   11 HLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNR-PPGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLL 251

HSP 3 Score: 65.855 bits (159), Expect = 2.129e-10
Identity = 33/94 (35.11%), Postives = 51/94 (54.26%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN-GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+RD +E  ++      G FL+R   N G+Y + + H  KV HY I++   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  167 WFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQK 260

[Close]

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP F  + + +
Sbjct:  397 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL 620

HSP 2 Score: 128.642 bits (322), Expect = 3.353e-30
Identity = 80/249 (32.13%), Postives = 131/249 (52.61%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            ++ YF G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R     + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   11 HLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNR-PPGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLL 251

HSP 3 Score: 65.855 bits (159), Expect = 2.129e-10
Identity = 33/94 (35.11%), Postives = 51/94 (54.26%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN-GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+RD +E  ++      G FL+R   N G+Y + + H  KV HY I++   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  167 WFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQK 260

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Syk (spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515])

HSP 1 Score: 268.085 bits (684), Expect = 2.607e-78
Identity = 113/208 (54.33%), Postives = 162/208 (77.88%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWS 2269
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+
Sbjct:  374 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 581

HSP 2 Score: 128.642 bits (322), Expect = 2.578e-30
Identity = 80/249 (32.13%), Postives = 131/249 (52.61%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            ++ YF G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R     + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   11 HLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNR-PPGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLL 251

HSP 3 Score: 65.4698 bits (158), Expect = 2.167e-10
Identity = 33/94 (35.11%), Postives = 51/94 (54.26%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN-GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+RD +E  ++      G FL+R   N G+Y + + H  KV HY I++   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  167 WFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQK 260

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Zap70 (zeta-chain (TCR) associated protein kinase [Source:MGI Symbol;Acc:MGI:99613])

HSP 1 Score: 255.758 bits (652), Expect = 1.869e-73
Identity = 121/240 (50.42%), Postives = 165/240 (68.75%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYL-RRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLST 2344
            I VA+K+LK+    K    E+M EA+ M QL + +IVRLIGVC+ E ++L++E+A  GP++K+L  + + +   ++ EL+ QV+ GM YLE   FVHRDLAARNVLLVN HYAKISDFG+SKAL     YY A +AGKWPLKWYAPECI + +F S+SDVWSYG+T+WE FSYG++PYK +KG ++L  + QG+R++ P  CP  +Y +M  CW      RP F  +   M      L++
Sbjct:  363 IDVAIKVLKQGTE-KADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSLAS 601

HSP 2 Score: 105.916 bits (263), Expect = 5.179e-23
Identity = 76/254 (29.92%), Postives = 129/254 (50.79%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFK-----DSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLR 811
            ++ +F+G I+R  AE+ L   G  +G+FLLR+ +   G YV+S+ H  + +H+ IE+Q +GT+ I  G+   GP EL + +    DG     R P  R P       L+     F  DC++   +    +     +  ++E+ +     Q ++ ++    H   PW+H  L R EAE +L +   T+G+FL+R RK    + LS+       HY I  +K  K  I  G  FD+L +L+++   + DGL+ +L+
Sbjct:    7 HLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPG------LEPQPGVF--DCLRDAMVRDYVRQTWKLEGDALEQAIISQAPQ-VEKLIATTAHERMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLK 251

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771])

HSP 1 Score: 201.83 bits (512), Expect = 1.534e-52
Identity = 97/234 (41.45%), Postives = 148/234 (63.25%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQ-SLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            IPVA+K+L +    K    E M+EA  M+ + H H+VRL+GVC    I L+ +L P G +  Y+  ++ ++  Q L+    Q+++GM YLE  + VHRDLAARNVL+ + ++ KI+DFG+++ L   +  Y A   GK P+KW A ECI+Y +F  +SDVWSYG+T+WE+ ++G +PY  +   +I  +L++G+RL +P  C   +Y VM++CW  D   RP F EL    SR+
Sbjct:  746 IPVAIKILNETTGPKANV-EFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977

[Close]

BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q64725|KSYK_RAT (Tyrosine-protein kinase SYK OS=Rattus norvegicus OX=10116 GN=Syk PE=1 SV=1)

HSP 1 Score: 277.33 bits (708), Expect = 2.349e-80
Identity = 118/224 (52.68%), Postives = 169/224 (75.45%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A  GP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI YF+F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP FA + + +
Sbjct:  397 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAAWGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMFLCWTYDVENRPGFAAVELRL 620

HSP 2 Score: 127.872 bits (320), Expect = 4.413e-29
Identity = 80/249 (32.13%), Postives = 132/249 (53.01%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            ++ YF G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    +G + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  F L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   11 HLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNR-PPGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLL 251

HSP 3 Score: 64.6994 bits (156), Expect = 3.366e-9
Identity = 32/94 (34.04%), Postives = 51/94 (54.26%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLR-ESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+RD +E  ++      G FL+R    NG++ + + H  KV HY I++   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  167 WFHGNISRDESEQTVLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQK 260

[Close]

BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P43405|KSYK_HUMAN (Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1)

HSP 1 Score: 276.559 bits (706), Expect = 4.174e-80
Identity = 118/224 (52.68%), Postives = 170/224 (75.89%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP FA + + +
Sbjct:  403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626

HSP 2 Score: 126.716 bits (317), Expect = 1.057e-28
Identity = 79/246 (32.11%), Postives = 130/246 (52.85%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR-PQGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252

HSP 3 Score: 68.9366 bits (167), Expect = 1.541e-10
Identity = 34/94 (36.17%), Postives = 53/94 (56.38%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLR-ESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHGKI+R+ +E +++      G FL+R    NG+Y + + H  KV HY I+K   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261

[Close]

BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|F1N9Y5|KSYK_CHICK (Tyrosine-protein kinase SYK OS=Gallus gallus OX=9031 GN=SYK PE=1 SV=2)

HSP 1 Score: 275.404 bits (703), Expect = 6.583e-80
Identity = 117/229 (51.09%), Postives = 175/229 (76.42%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            PVAVK+LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NK+L++N+ ++E+++ EL+ QVS GM YLE + FVHRDLAARNVLLV +HYAKISDFG+SKAL+  ++YY+A + GKWP+KWYAPEC+ +++F SKSDVWS+G+ +WE FSYG++PYK +KG ++  M+++G+R++ P  CP  +YD+M  CW+ +   RP F  + + +
Sbjct:  376 PVAVKILKNESNDPAIKDELLREANVMQQLDNPYIVRMIGICEAEAWMLVMEMAELGPLNKFLQKNRHVTEKNITELVHQVSMGMKYLEENNFVHRDLAARNVLLVTQHYAKISDFGLSKALSADENYYKAQSHGKWPVKWYAPECMNFYKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGGEVAQMIERGERMECPEACPVEVYDLMKLCWTYNVDDRPGFVAVELRL 604

HSP 2 Score: 127.102 bits (318), Expect = 7.007e-29
Identity = 88/269 (32.71%), Postives = 139/269 (51.67%), Query Frame = 2

Query:   47 IMSQGKSPFNIL-YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECP 829
            + S   +P N L YF G ITR+ AE+ LM  G  +G++LLR+S N  G + +S+ +  KV+HY IE++  GT+ I  G+    P EL+ +H    DG + L R    R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E R+       G+FL+R+R  +  + L +    +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL  L   I CP
Sbjct:    1 MASNMANPANHLPYFFGNITREEAEEYLMQGGMSDGLYLLRQSRNYLGGFALSLAYGRKVHHYTIERELSGTYAIAGGKSHASPAELINYHSEEADGLICLLRKSFNR-PPGVE------PKTGPFEDLKENLIREYVKQTWNLQGHALEQAIIS-QKPQLEKLIATTAHEKMPWFHGRISREESEHRILIGSRNNGKFLIRERDSNGSYALCLLNDGKVLHYRIDRDKTGKLSIPDGKRFDTLWQLVEHYSYKPDGLLRVL--SIPCP 259

HSP 3 Score: 63.5438 bits (153), Expect = 7.666e-9
Identity = 32/95 (33.68%), Postives = 53/95 (55.79%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERY 364
            +FHG+I+R+ +E  ++      G FL+RE   NG+Y + + +  KV HY I++   G   I  G++F    +LVEH+    DG L +  +P  R+
Sbjct:  167 WFHGRISREESEHRILIGSRNNGKFLIRERDSNGSYALCLLNDGKVLHYRIDRDKTGKLSIPDGKRFDTLWQLVEHYSYKPDGLLRVLSIPCPRH 261

[Close]

BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P48025|KSYK_MOUSE (Tyrosine-protein kinase SYK OS=Mus musculus OX=10090 GN=Syk PE=1 SV=2)

HSP 1 Score: 275.018 bits (702), Expect = 1.408e-79
Identity = 117/224 (52.23%), Postives = 169/224 (75.45%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE S FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +YD+M  CW+ D   RP F  + + +
Sbjct:  397 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL 620

HSP 2 Score: 128.642 bits (322), Expect = 2.346e-29
Identity = 80/249 (32.13%), Postives = 131/249 (52.61%), Query Frame = 2

Query:   74 NILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            ++ YF G ITR+ AED L+  G  +G++LLR+S N  G + +S+ H  K +HY IE++ +GT+ I  GR    P +L  +H    DG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R     + L +  + +  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   11 HLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNR-PPGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLL 251

HSP 3 Score: 65.855 bits (159), Expect = 1.489e-9
Identity = 33/94 (35.11%), Postives = 51/94 (54.26%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN-GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+RD +E  ++      G FL+R   N G+Y + + H  KV HY I++   G   I  G+KF    +LVEH+    DG L +  +P ++
Sbjct:  167 WFHGNISRDESEQTVLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQK 260

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BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q00655|KSYK_PIG (Tyrosine-protein kinase SYK OS=Sus scrofa OX=9823 GN=SYK PE=1 SV=1)

HSP 1 Score: 270.781 bits (691), Expect = 5.823e-78
Identity = 115/224 (51.34%), Postives = 168/224 (75.00%), Query Frame = 2

Query: 1646 MLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            +LK E +      E++ EA  M QL + +IVR+IG+C+ E  +L++E+A LGP+NKYL++N+ + ++++IEL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKAL   ++YY+A   GKWP+KWYAPECI Y++F SKSDVWS+G+ +WE FSYG++PY+ +KG+++ +ML++G+R+  P  CP  +Y++M  CW+ D   RP F  + + +
Sbjct:  396 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEECNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVSAMLEKGERMGCPPGCPREMYELMTLCWTYDVENRPGFVAVELRL 619

HSP 2 Score: 125.946 bits (315), Expect = 1.756e-28
Identity = 81/246 (32.93%), Postives = 133/246 (54.07%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFED----CIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F G+ITR+ AED L+  G  +G++LLR+S N  G + +S+ +  K +HY IE++ +GT+ I  GR    P EL  +H   LDG + L + P  R P G         K+  FED     I++   +       ++E+ +    +  L+ ++    H   PWFH  + R E+E+ +     T G+FL+R R  +  + L +  + +  HY+I  +K  KL I GG+ FD+L +L++HY ++ DGLL
Sbjct:   10 FFFGQITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAYDRKAHHYTIERELNGTYAISGGRTHGSPAELCHYHSQELDGLVCLLKNPFNR-PPGVQ------PKTGPFEDLKENLIREYVKQTWNLQGQALEQAIIS-QKPQLEKLIATTAHEKMPWFHGKISRDESEQIVLIGSKTNGKFLIRARD-NGSYALGLLHEGKVLHYRIDKDKTGKLSIPGGKNFDTLWQLVEHYSYKSDGLL 246

HSP 3 Score: 72.7886 bits (177), Expect = 9.912e-12
Identity = 34/93 (36.56%), Postives = 52/93 (55.91%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHGKI+RD +E +++      G FL+R   NG+Y + + H  KV HY I+K   G   I  G+ F    +LVEH+    DG L +  +P ++
Sbjct:  163 WFHGKISRDESEQIVLIGSKTNGKFLIRARDNGSYALGLLHEGKVLHYRIDKDKTGKLSIPGGKNFDTLWQLVEHYSYKSDGLLRVLTVPCQK 255

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A5K3ELS1 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 397.897 bits (1021), Expect = 6.076e-125
Identity = 223/428 (52.10%), Postives = 275/428 (64.25%), Query Frame = 2

Query: 1169 VFQWNNSISSSTQSFVNDTRQTNDTP-KVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSR--------------------QVISPSLEVEISRNRIKSSSMPPKL--------------QPWDLGILD--PMLAV-----ETQKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            VF+ NN  S +TQ   + TR     P K S N       +++  +SLN P I D LW EP+ +  R                     +++P L +  S    +     P +              QP    + D  P  +V     E QKIYDSL   D +  LP + + + ++LGGGNFG V  G YK      + VAVK LK+   +  G   I+ EA+TM+QL+H+HIVRLIGVCK ++ +L+LELAPLGPINKYL+++   S   L ELM QV++GMAYLE+ K VHRDLAARNVLLV + +AKISDFGMSKALN+G DYYRAA+AGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKD+KG QIL+MLDQG RL +P  CPE IY VM QCW+ +GVRRPTF ELV+TMSR+
Sbjct:   27 VFRTNNFASGATQRTASATRNPQLPPCKFSPN-------NSLPPESLNFPPIIDALWEEPDGSEERSQPSSSMASINLESLPPPPPHILNPFLPLTTSAVSPQPCHHAPGVSTFCNSTCCQRKESQPNSPQLRDTTPPASVLPAIEEAQKIYDSLP--DNTLFLPPESLSLMERLGGGNFGQVVKGIYKTPHGLDVQVAVKTLKESQIACTGEQTILAEAKTMTQLKHRHIVRLIGVCKAQRFMLVLELAPLGPINKYLKKHPDTSVCVLAELMHQVAQGMAYLESCKLVHRDLAARNVLLVTQRFAKISDFGMSKALNFGNDYYRAASAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDMKGAQILAMLDQGLRLSRPARCPEPIYAVMQQCWNAEGVRRPTFTELVLTMSRL 445

[Close]

BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A158QUA3 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS5960 PE=3 SV=1)

HSP 1 Score: 397.512 bits (1020), Expect = 9.766e-122
Identity = 223/428 (52.10%), Postives = 275/428 (64.25%), Query Frame = 2

Query: 1169 VFQWNNSISSSTQSFVNDTRQTNDTP-KVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSR--------------------QVISPSLEVEISRNRIKSSSMPPKL--------------QPWDLGILD--PMLAV-----ETQKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            VF+ NN  S +TQ   + TR     P K S N       +++  +SLN P I D LW EP+ +  R                     +++P L +  S    +     P +              QP    + D  P  +V     E QKIYDSL   D +  LP + + + ++LGGGNFG V  G YK      + VAVK LK+   +  G   I+ EA+TM+QL+H+HIVRLIGVCK ++ +L+LELAPLGPINKYL+++   S   L ELM QV++GMAYLE+ K VHRDLAARNVLLV + +AKISDFGMSKALN+G DYYRAA+AGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKD+KG QIL+MLDQG RL +P  CPE IY VM QCW+ +GVRRPTF ELV+TMSR+
Sbjct:  263 VFRTNNFASGATQRTASATRNPQLPPCKFSPN-------NSLPPESLNFPPIIDALWEEPDGSEERSQPSSSMASINLESLPPPPPHILNPFLPLTTSAVSPQPCHHAPGVSTFCNSTCCQRKESQPNSPQLRDTTPPASVLPAIEEAQKIYDSLP--DNTLFLPPESLSLMERLGGGNFGQVVKGIYKTPHGLDVQVAVKTLKESQIACTGEQTILAEAKTMTQLKHRHIVRLIGVCKAQRFMLVLELAPLGPINKYLKKHPDTSVCVLAELMHQVAQGMAYLESCKLVHRDLAARNVLLVTQRFAKISDFGMSKALNFGNDYYRAASAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDMKGAQILAMLDQGLRLSRPARCPEPIYAVMQQCWNAEGVRRPTFTELVLTMSRL 681

HSP 2 Score: 65.4698 bits (158), Expect = 5.932e-7
Identity = 39/121 (32.23%), Postives = 65/121 (53.72%), Query Frame = 2

Query:  761 LIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTA-------VKTDLSRIVTDKYRDMSINS-IFRQKKSDMISVSSDLISFSEWSTNLPRLLNE 1099
            +IDHY+FRQDGLLCKLR  +  P FIR+K +   S++  S + + S++   ++   + RTA          +++        D +  S + R+   D++  S+DLISF++W      L N+
Sbjct:    1 MIDHYHFRQDGLLCKLRKVVAAPDFIRTKQDS-ASISSESPQGSPSSLKKPESTMNVSRTASHSLPSLASLNVTSPTVATSNDTNRGSPVIRKVNEDVMHSSTDLISFNDWPNVTSLLANQ 120

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A183MH92 (Protein kinase domain-containing protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS15417 PE=3 SV=1)

HSP 1 Score: 392.889 bits (1008), Expect = 1.322e-120
Identity = 192/280 (68.57%), Postives = 226/280 (80.71%), Query Frame = 2

Query: 1487 QKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            Q+IYD L  ++  F L    + +K++LGGGNFG+V  G Y+    + +PVAVK LK       G  EI+ EARTM+QL+H+HIVRLIGVCK EQ +L+LELAPLGPINKYL++   +S  +L ELM QV+ GMAYLE+ KFVHRDLAARNVLLV  H+AKISDFGMSKALN+G DYYRAA AGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEV+SYGERPY+D+KG QIL+MLDQG RL +P  CPESIY VM QCW+ +GV RPTFAELV+T+SRI
Sbjct:  285 QQIYDELPPSN--FLLNSQTVTLKERLGGGNFGHVVKGLYRTPSGQEVPVAVKTLKPNQIVNSGEREILAEARTMAQLKHRHIVRLIGVCKEEQFMLVLELAPLGPINKYLKKRPDVSVHTLTELMHQVALGMAYLESCKFVHRDLAARNVLLVTRHFAKISDFGMSKALNFGSDYYRAATAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQGLRLSRPSRCPESIYSVMQQCWNFEGVHRPTFAELVLTISRI 562

[Close]

BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: G4VKS4 (Tyrosine kinase OS=Schistosoma mansoni OX=6183 GN=Smp_149460 PE=3 SV=1)

HSP 1 Score: 394.815 bits (1013), Expect = 2.802e-120
Identity = 191/280 (68.21%), Postives = 227/280 (81.07%), Query Frame = 2

Query: 1487 QKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            Q+IYD L  ++  F L    + +K++LGGGNFG+V  G Y+    + +PVAVK LK    +  G  EI+ EARTM+QL+H+HIVRLIGVCK EQ +L+LELAPLGPINKYL++   +S  +L ELM QV+ GMAYLE+ KFVHRDLAARNVLLV  H+AKISDFGMSKALN+G DYYRAA AGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEV+SYGERPY+D+KG QIL+MLDQG RL +P  CPESIY +M QCW+ +GV RPTFAELV+T+SRI
Sbjct:  372 QQIYDELPPSN--FLLNSQTVTLKERLGGGNFGHVVKGLYRTPSGQEVPVAVKTLKPNQIANSGEREILAEARTMAQLKHRHIVRLIGVCKEEQFMLVLELAPLGPINKYLKKRPDVSVHTLTELMHQVALGMAYLESCKFVHRDLAARNVLLVTRHFAKISDFGMSKALNFGSDYYRAATAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQGLRLSRPSRCPESIYSIMQQCWNFEGVHRPTFAELVLTISRI 649

[Close]

BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A0X3P5I8 (Tyrosine-protein kinase SYK (Fragment) OS=Schistocephalus solidus OX=70667 GN=KSYK PE=4 SV=1)

HSP 1 Score: 383.645 bits (984), Expect = 7.000e-120
Identity = 184/279 (65.95%), Postives = 226/279 (81.00%), Query Frame = 2

Query: 1481 ETQKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            E QKIYDSL   + +F L  D + + ++LGGGNFG V  G Y+    + +PVAVK LK+   +  G   I+ EA+ M+QL+H+HIVRLIGVCK ++ +L+LELAPLGPINK+L+++   S   + +LM QV++GMAYLE+ KFVHRDLAARNVLLV + +AKISDFGMSKALN+G DYYRAA+AGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFS+GERPYKD+KG QILSMLDQG RL +P  CPE++Y VM +CW+ +GVRRPTFAELV+TM
Sbjct:  120 EAQKIYDSLP--ESTFFLNPDHLSLMERLGGGNFGQVVKGIYRTPHGQEVPVAVKTLKESQIASTGEQSILSEAKMMTQLKHRHIVRLIGVCKAQRFMLVLELAPLGPINKFLKKHPDTSVNVITDLMYQVAQGMAYLESCKFVHRDLAARNVLLVTQRFAKISDFGMSKALNFGNDYYRAASAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSFGERPYKDMKGAQILSMLDQGLRLSRPARCPEAVYAVMRECWNFEGVRRPTFAELVLTM 396

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BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: zap70 (tyrosine-protein kinase ZAP-70 [Source:NCBI gene;Acc:103044019])

HSP 1 Score: 274.633 bits (701), Expect = 8.245e-81
Identity = 124/231 (53.68%), Postives = 170/231 (73.59%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLR-RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            I VA+K+LK E + K    E+M EA  M QL + +IVR+IG+C+ E ++L++E+AP GP+NK+L  +   +S ++++ELM QVS GM YLE   FVHRDLAARNVLLVN+HYAKISDFG+SKAL    +YY+A   GKWPLKWYAPECI + +F +K DVWSYG+T+WE FSYG +PYK +KG +++SM+  G R++ P  CPE++Y+VM  CW+     RP+F ++   M
Sbjct:  332 IDVAIKILKSE-NEKAVKDEMMREAEIMHQLDNPYIVRMIGLCQAEALMLVMEMAPAGPLNKFLSSKKDQVSVENVVELMHQVSLGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGADDNYYKARTLGKWPLKWYAPECINFHKFSNKGDVWSYGVTMWEAFSYGGKPYKKMKGPEVISMIQNGNRMECPAGCPEAMYEVMKDCWTYKYEERPSFVKVEEKM 561

HSP 2 Score: 102.449 bits (254), Expect = 4.751e-22
Identity = 75/246 (30.49%), Postives = 126/246 (51.22%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLR 811
            +F+G I+R  AE  L   G  +G+FLLR+ +   G YV+S+    +  HY +EKQ +GTF I  G+   GP EL E++    DG + + R P  R  A T   I  GV  +  ++ +++        +  ++E+ +     Q L+ ++    H    W+H  + R E E RL +    +G+FLVR+R     F LS+       HY+++ +K  K  +  G  FD++ +L+++   + DGL+  LR
Sbjct:   10 FFYGSISRSEAEQHLKLAGMSDGLFLLRQCLRSLGGYVLSLVWNLEFYHYPVEKQLNGTFCISGGKPHCGPAELCEYYSKDADGLVCMLRKPCLR-TAETP--IKHGVFDNLRDNMLREYVRHTWNLEGEAMEQAIISQAPQ-LEKLIATTAHEKMLWYHGKIPRQEGERRLYSGSQPDGKFLVRERDESGTFALSVMYGKTAYHYQVLHDKSGKYSMPEGTKFDTVWQLVEYLKMKPDGLVTLLR 251

HSP 3 Score: 55.4546 bits (132), Expect = 2.243e-7
Identity = 30/91 (32.97%), Postives = 47/91 (51.65%), Query Frame = 2

Query:   77 ILYFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLAR 346
            +L++HGKI R   E  L S    +G FL+RE   +G + +S+ +     HY +     G + +  G KF    +LVE+  +  DG +TL R
Sbjct:  161 MLWYHGKIPRQEGERRLYSGSQPDGKFLVRERDESGTFALSVMYGKTAYHYQVLHDKSGKYSMPEGTKFDTVWQLVEYLKMKPDGLVTLLR 251

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: zap70 (tyrosine-protein kinase ZAP-70 [Source:NCBI gene;Acc:103044019])

HSP 1 Score: 274.633 bits (701), Expect = 1.366e-80
Identity = 124/231 (53.68%), Postives = 170/231 (73.59%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLR-RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            I VA+K+LK E + K    E+M EA  M QL + +IVR+IG+C+ E ++L++E+AP GP+NK+L  +   +S ++++ELM QVS GM YLE   FVHRDLAARNVLLVN+HYAKISDFG+SKAL    +YY+A   GKWPLKWYAPECI + +F +K DVWSYG+T+WE FSYG +PYK +KG +++SM+  G R++ P  CPE++Y+VM  CW+     RP+F ++   M
Sbjct:  353 IDVAIKILKSE-NEKAVKDEMMREAEIMHQLDNPYIVRMIGLCQAEALMLVMEMAPAGPLNKFLSSKKDQVSVENVVELMHQVSLGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGADDNYYKARTLGKWPLKWYAPECINFHKFSNKGDVWSYGVTMWEAFSYGGKPYKKMKGPEVISMIQNGNRMECPAGCPEAMYEVMKDCWTYKYEERPSFVKVEEKM 582

HSP 2 Score: 102.834 bits (255), Expect = 3.677e-22
Identity = 75/246 (30.49%), Postives = 126/246 (51.22%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLR 811
            +F+G I+R  AE  L   G  +G+FLLR+ +   G YV+S+    +  HY +EKQ +GTF I  G+   GP EL E++    DG + + R P  R  A T   I  GV  +  ++ +++        +  ++E+ +     Q L+ ++    H    W+H  + R E E RL +    +G+FLVR+R     F LS+       HY+++ +K  K  +  G  FD++ +L+++   + DGL+  LR
Sbjct:   10 FFYGSISRSEAEQHLKLAGMSDGLFLLRQCLRSLGGYVLSLVWNLEFYHYPVEKQLNGTFCISGGKPHCGPAELCEYYSKDADGLVCMLRKPCLR-TAETP--IKHGVFDNLRDNMLREYVRHTWNLEGEAMEQAIISQAPQ-LEKLIATTAHEKMLWYHGKIPRQEGERRLYSGSQPDGKFLVRERDESGTFALSVMYGKTAYHYQVLHDKSGKYSMPEGTKFDTVWQLVEYLKMKPDGLVTLLR 251

HSP 3 Score: 55.8398 bits (133), Expect = 1.769e-7
Identity = 30/91 (32.97%), Postives = 47/91 (51.65%), Query Frame = 2

Query:   77 ILYFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLAR 346
            +L++HGKI R   E  L S    +G FL+RE   +G + +S+ +     HY +     G + +  G KF    +LVE+  +  DG +TL R
Sbjct:  161 MLWYHGKIPRQEGERRLYSGSQPDGKFLVRERDESGTFALSVMYGKTAYHYQVLHDKSGKYSMPEGTKFDTVWQLVEYLKMKPDGLVTLLR 251

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: zap70 (tyrosine-protein kinase ZAP-70 [Source:NCBI gene;Acc:103044019])

HSP 1 Score: 274.633 bits (701), Expect = 1.366e-80
Identity = 124/231 (53.68%), Postives = 170/231 (73.59%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLR-RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTM 2317
            I VA+K+LK E + K    E+M EA  M QL + +IVR+IG+C+ E ++L++E+AP GP+NK+L  +   +S ++++ELM QVS GM YLE   FVHRDLAARNVLLVN+HYAKISDFG+SKAL    +YY+A   GKWPLKWYAPECI + +F +K DVWSYG+T+WE FSYG +PYK +KG +++SM+  G R++ P  CPE++Y+VM  CW+     RP+F ++   M
Sbjct:  353 IDVAIKILKSE-NEKAVKDEMMREAEIMHQLDNPYIVRMIGLCQAEALMLVMEMAPAGPLNKFLSSKKDQVSVENVVELMHQVSLGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGADDNYYKARTLGKWPLKWYAPECINFHKFSNKGDVWSYGVTMWEAFSYGGKPYKKMKGPEVISMIQNGNRMECPAGCPEAMYEVMKDCWTYKYEERPSFVKVEEKM 582

HSP 2 Score: 102.834 bits (255), Expect = 3.677e-22
Identity = 75/246 (30.49%), Postives = 126/246 (51.22%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLR 811
            +F+G I+R  AE  L   G  +G+FLLR+ +   G YV+S+    +  HY +EKQ +GTF I  G+   GP EL E++    DG + + R P  R  A T   I  GV  +  ++ +++        +  ++E+ +     Q L+ ++    H    W+H  + R E E RL +    +G+FLVR+R     F LS+       HY+++ +K  K  +  G  FD++ +L+++   + DGL+  LR
Sbjct:   10 FFYGSISRSEAEQHLKLAGMSDGLFLLRQCLRSLGGYVLSLVWNLEFYHYPVEKQLNGTFCISGGKPHCGPAELCEYYSKDADGLVCMLRKPCLR-TAETP--IKHGVFDNLRDNMLREYVRHTWNLEGEAMEQAIISQAPQ-LEKLIATTAHEKMLWYHGKIPRQEGERRLYSGSQPDGKFLVRERDESGTFALSVMYGKTAYHYQVLHDKSGKYSMPEGTKFDTVWQLVEYLKMKPDGLVTLLR 251

HSP 3 Score: 55.8398 bits (133), Expect = 1.769e-7
Identity = 30/91 (32.97%), Postives = 47/91 (51.65%), Query Frame = 2

Query:   77 ILYFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLAR 346
            +L++HGKI R   E  L S    +G FL+RE   +G + +S+ +     HY +     G + +  G KF    +LVE+  +  DG +TL R
Sbjct:  161 MLWYHGKIPRQEGERRLYSGSQPDGKFLVRERDESGTFALSVMYGKTAYHYQVLHDKSGKYSMPEGTKFDTVWQLVEYLKMKPDGLVTLLR 251

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BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: syk (spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040702-3])

HSP 1 Score: 251.906 bits (642), Expect = 1.048e-72
Identity = 110/223 (49.33%), Postives = 165/223 (73.99%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + +++    E++ EA  M +L + +IVR+IG+C+ E ++L++ELA LGP++KYL+RN+ ++ +++ EL+ QV  GM YLE S FVHRDLAARNVLLV +HYAKISDFG+S+AL   +  Y     GKWP+KWYAPEC+ +F+F  KSDVWS+G+ +WE +SYG++PYK +KG +++ M+++G+R+  P +CP  +Y++M +        RP FA
Sbjct:  340 PVAVKILKNDENNEAVKQEMLREAEVMQKLDNPYIVRMIGICEAENLMLVMELAELGPLHKYLQRNKHVTSKNITELVHQVCMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSRALG-EERIYNCLCPGKWPVKWYAPECMNFFKFSCKSDVWSFGVLMWEAYSYGQKPYKGMKGNEVIQMVERGERMAAPADCPPEMYELMKKMVDD----RPGFA 557

HSP 2 Score: 124.405 bits (311), Expect = 4.062e-29
Identity = 80/254 (31.50%), Postives = 133/254 (52.36%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGF 835
            +F+G I R+ AE+ L   G  +G++LLR+S N  G + +S+ +  +  HY IEK+ + TF I+ G+    P +++E+H    DG + L + P  R P G    +  G      E  I++   +      +++E+ +    R  L+ ++    H   PWFH  + R ++E RL  +    G+FL+RQR  +  F L +   +Q  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL  L      P F
Sbjct:   10 FFYGNIAREEAEEYLRHAGMSDGLYLLRQSRNYLGGFALSVAYNRQCYHYTIEKELNETFAIVGGKSHRTPQDVIEYHSQESDGLICLLKKPCNR-PRGVQPKV--GAFEDVKEKLIRQYVTQTWNLQGAALEQAIIS-QRPQLEKLIATTAHEKMPWFHGNITREDSELRLHGSSRVNGKFLIRQRDTNGSFALCLLHNHQVMHYRIDRDKAGKLSIPDGKKFDTLWQLVEHYTYKPDGLLRVLTEACPHPAF 259

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: syk (spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040702-3])

HSP 1 Score: 252.677 bits (644), Expect = 1.124e-72
Identity = 107/216 (49.54%), Postives = 162/216 (75.00%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDG 2278
            PVAVK+LK + +++    E++ EA  M +L + +IVR+IG+C+ E ++L++ELA LGP++KYL+RN+ ++ +++ EL+ QV  GM YLE S FVHRDLAARNVLLV +HYAKISDFG+S+AL   +  Y     GKWP+KWYAPEC+ +F+F  KSDVWS+G+ +WE +SYG++PYK +KG +++ M+++G+R+  P +CP  +Y++M +     G
Sbjct:  381 PVAVKILKNDENNEAVKQEMLREAEVMQKLDNPYIVRMIGICEAENLMLVMELAELGPLHKYLQRNKHVTSKNITELVHQVCMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSRALGE-ERIYNCLCPGKWPVKWYAPECMNFFKFSCKSDVWSFGVLMWEAYSYGQKPYKGMKGNEVIQMVERGERMAAPADCPPEMYELMKKMLDVQG 595

HSP 2 Score: 126.716 bits (317), Expect = 9.256e-30
Identity = 82/274 (29.93%), Postives = 140/274 (51.09%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAH 895
            +F+G I R+ AE+ L   G  +G++LLR+S N  G + +S+ +  +  HY IEK+ + TF I+ G+    P +++E+H    DG + L + P  R P G    +  G      E  I++   +      +++E+ +    R  L+ ++    H   PWFH  + R ++E RL  +    G+FL+RQR  +  F L +   +Q  HY+I  +K  KL I  G+ FD+L +L++HY ++ DGLL  L      P F    A+    +  +  ++ H
Sbjct:   10 FFYGNIAREEAEEYLRHAGMSDGLYLLRQSRNYLGGFALSVAYNRQCYHYTIEKELNETFAIVGGKSHRTPQDVIEYHSQESDGLICLLKKPCNR-PRGVQPKV--GAFEDVKEKLIRQYVTQTWNLQGAALEQAIIS-QRPQLEKLIATTAHEKMPWFHGNITREDSELRLHGSSRVNGKFLIRQRDTNGSFALCLLHNHQVMHYRIDRDKAGKLSIPDGKKFDTLWQLVEHYTYKPDGLLRVLTEACPHPAFSHQSADGRPGVPPNHPQTGH 279

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006670.1 (pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene:ENSPMAG00000006016.1 transcript:ENSPMAT00000006670.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 195.667 bits (496), Expect = 3.010e-55
Identity = 94/232 (40.52%), Postives = 145/232 (62.50%), Query Frame = 2

Query: 1622 ETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLR--RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNY-GQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            +T PVA+K LK+    +    + + EA+ M +LRH  +++L  VC  E+ I +I EL   G +  YL+    +SL    L+++ +QV+ GMAYLEA  ++HRDLAARN+L+   +  K++DFG+++ +    +D Y A    K+P+KW APE   Y RF  KSDVWS+G+ L E+ +YG+ PY      ++L+ +D+G R+  P  CP++ YD+ML+CW+ D   RPTF  L
Sbjct:  135 KTTPVAIKTLKQGTMDR---DDFLREAQLMKRLRHPKLIQLYAVCTQEEPIYIITELMSNGSLANYLQTPEGRSLDLVELVDMAAQVAAGMAYLEAQNYIHRDLAARNILVAEHNACKVADFGLARVIKMSNEDEYEARVGSKFPIKWTAPEAANYNRFSIKSDVWSFGVLLHEIITYGKLPYPGQTNAEVLAAVDRGYRMPCPPGCPQAFYDLMLECWNVDDQARPTFETL 363

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 196.438 bits (498), Expect = 3.363e-52
Identity = 95/234 (40.60%), Postives = 148/234 (63.25%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRN-QSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            IPVA+K+L+ E  S     EI++EA  M+ + H H+VRL+G+C    + L+ +L PLG + +Y R + + +  Q L+    Q+++GM YLE  + VHRDLAARNVL+    + KI+DFG+++ L+  +  Y A   GK P+KW A E I Y  F  +SDVWSYG+T+WE+ ++G +PY+ +    I  +L++G+RL +P  C   +Y +M++CW  D   RP F EL +  S++
Sbjct:  602 IPVAIKVLR-EATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQLVTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLLDINEIEYHADG-GKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTFGGKPYEGIPARDIPELLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFKELAVEFSKM 833

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 187.963 bits (476), Expect = 7.263e-52
Identity = 94/228 (41.23%), Postives = 138/228 (60.53%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLRR--NQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYG-QDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            VAVK LK     K    E + EA+ M QLRH ++++L  VC  E+ I +I EL   G +  YLR    + L    L+++  Q++ GMAYLE+  ++HRDLAARN+L+      K++DFG+++ +    +D Y   A  K P+KW APE + + RF  KSDVWS+GI L+E+ +YG  PY ++   ++L  LD+G R+ +P NCP   Y +ML+CW+     RPTF  L
Sbjct:  214 VAVKTLKPGAMKK---EEFIGEAQIMKQLRHANLIQLYAVCSQEEPIYIITELMRHGSLLDYLRGPLGKQLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDNCPPLFYSIMLECWNKKEEERPTFETL 438

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001705.1 (pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 gene:ENSPMAG00000001543.1 transcript:ENSPMAT00000001705.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 176.022 bits (445), Expect = 5.879e-50
Identity = 88/240 (36.67%), Postives = 133/240 (55.42%), Query Frame = 2

Query: 1697 EARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLRRNQS-----------------------LSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLST 2344
            EA  M++  H +IV+L+GVC   +   L+ E  P G +N+YLRR  S                       L     + + +QV+ GMAYL   KFVHRDLA RN L+ N    KISDFG+S+++ Y  DYY+A      P++W  PE I+Y R+ S+SDVW++G+ LWE+FS+G +PY  +   +++  +  G  L  P  CP  +Y++M  CW+     RP+FA +   ++R+   L+ 
Sbjct:   11 EAALMAEFTHPNIVKLLGVCAVGKPFCLLFEFMPHGDLNEYLRRCSSEAGLAASSPPARAPTSSGSEPVSLCCADKLFVATQVAAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSI-YAADYYKANENDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSHGLQPYFGMSHEEVIYFVRDGNVLACPDGCPLDLYNLMRLCWAHAPADRPSFASVQHVLARMHAQLTA 249

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 179.874 bits (455), Expect = 8.667e-50
Identity = 92/231 (39.83%), Postives = 136/231 (58.87%), Query Frame = 2

Query: 1622 ETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQ-ILLILELAPLGPINKYLRRNQS--LSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            +T  VAVK LK      +   E + EA  M +  H ++++L  VC  E+ I +I EL   G + +YL+ ++   L    LI +  QV+ GMAYLEA  ++HRDLAARN+L+ +    K++DFG+++ +    D Y A   GK+P+KW APE   Y RF  KSDVWS+GI L+E+ +YG+ PY  +   ++L  L+ G R+  P NCP   Y +M  CW  +   RP+F +L
Sbjct:  144 KTTRVAVKTLKP---GAMVPEEFLAEAHIMKRFTHCNLIQLYAVCTTEEPIYIITELMVNGSLLQYLQNDEGGVLKMCHLINMAVQVASGMAYLEAQNYIHRDLAARNILVGDNLTCKVADFGLARVIK--DDEYIAREGGKFPVKWTAPEAANYSRFTIKSDVWSFGILLYEIVTYGKVPYAGMTNAEVLEELEHGYRMPCPTNCPRDFYSIMYNCWHKEEACRPSFLQL 369

HSP 2 Score: 51.2174 bits (121), Expect = 7.320e-7
Identity = 33/93 (35.48%), Postives = 50/93 (53.76%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCN-----KVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTL 340
            +F GKI+R  A  LL+++G   G FL+RES +  G Y +S+   +     +V HY+I+    G F I     F    +LV HH+L  +G  +L
Sbjct:    1 WFFGKISRADAVKLLLARGNDHGSFLIRESESKHGAYALSVSEWDALQGVEVRHYHIQPLEGGGFTINKRAAFSTLQDLVRHHVLEANGLKSL 93

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 88.1965 bits (217), Expect = 3.535e-18
Identity = 64/218 (29.36%), Postives = 107/218 (49.08%), Query Frame = 2

Query: 1688 IMEEARTMSQLRHKHIVRLIGVCKCEQIL-LILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYY-RAAAAGKWPLKWYAPECIYYFR-FDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQ--------CWSTDGVRRPTFAELV 2308
            +  E  T+  L H +IV+ +G      I  L LE    G +   +R      E  +  L +QV +G+AYL +   +HRD+ A N+LL  +   KISDFG+S+     +D Y  +    +  + W APE +   + + +K D+WS G  + E+F+ G+RP+ +L+   + +M   G+    P   PE    ++ Q        C+  +  +RPT  EL+
Sbjct: 1225 LRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRK---SKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWSNLE--VVAAMFKIGKSKSAPP-IPEDTLPLISQIGRNFLDACFEINPEKRPTANELL 1435

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BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 87.0409 bits (214), Expect = 8.275e-18
Identity = 62/227 (27.31%), Postives = 112/227 (49.34%), Query Frame = 2

Query: 1634 VAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIG-VCKCEQILLILELAPLGPINKYLRRNQS-LSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELV 2308
            VA+K +  E   ++  ++IM E   +  L H +IV+  G + K  ++ ++LE    G + + + R+ + LSE      ++Q   G+ YL     +HRD+ A N+LL  ++  K++DFG+S  +N       +A      L W APE +      + SD+WS G T+ E+ +    PY +L    I   + +      P +  E + D + +C+  +  +RPT  +L+
Sbjct:   51 VAIKEVVYENDEEL--NDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVN------SSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNP-PYHNLTDANIYYAV-ENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLL 267

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 79.7221 bits (195), Expect = 1.052e-15
Identity = 53/219 (24.20%), Postives = 99/219 (45.21%), Query Frame = 2

Query: 1655 KEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCK-CEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELV 2308
            + +H K+    +  E   + +L H++IV   G  +    + + LE  P G ++  L       E  +     Q+  G+AYL     +HRD+   N+L+  +   KI+DFG+SK L+         A+ +  + W +PE +      +K+D+WS G  + E+F+ G+ P+ D    Q +  +      + P        + + + +  D   RP+  EL+
Sbjct:  491 QNIHRKM-VDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT-GKHPFPDFSQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELL 707

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 78.5666 bits (192), Expect = 3.610e-15
Identity = 54/216 (25.00%), Postives = 100/216 (46.30%), Query Frame = 2

Query: 1685 EIMEEARTMSQ------LRHKHIVRLIGVCK-CEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDS-KSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELV 2308
            EI  + RT+ +      L H HI RL  +C       ++ E    G +  Y+ ++ SL E    +    ++  + YL A+  VHRDL   N+++ +    KI DFG+S   +Y +  +    +    L + APE +    +   + D+WS+GI L+ V   G+ P+ D   + +   + +G ++  P +    +  ++ +    D +RR T   +V
Sbjct:  163 EIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGS----LYFAAPELLKAQPYTGPEVDIWSFGIVLY-VLVCGKVPFDDENSSILHEKIKKG-KVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVV 372

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 73.559 bits (179), Expect = 3.638e-14
Identity = 56/223 (25.11%), Postives = 102/223 (45.74%), Query Frame = 2

Query: 1637 AVKMLKKEMHSKIGAHEIMEEARTMSQL-RHKHIVRLIGVCK-CEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPL----KWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRR 2287
            A+K+LKK+   K+   E   + R M +L  H  ++R+ G  +    I ++++    G +   LR++Q           ++V   + YL A   ++RDL   N+LL    + KI+DFG +K +              W L     + APE I    ++   D WS G+ ++E+ + G  P+ D    +    + QG+ +  P   P+ + D++ +  + D  RR
Sbjct:   97 AIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQ----------TVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLA-GYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVV-DLLSKLITADLTRR 307

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO31298 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYB5])

HSP 1 Score: 268.085 bits (684), Expect = 1.243e-82
Identity = 134/261 (51.34%), Postives = 184/261 (70.50%), Query Frame = 2

Query: 1523 SFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            +F L ++ + + ++LG GNFG V  G YK+   E IPVAVK LK +  +   + EI+ EAR M +L H +IVR+IG+C+   ++L++ELA  GP+NKYL++N+ +   +++ LM QV+ GM YLE+ +FVHRDLAARNVL+VN+ + KISDFGMS+A+  G DYY+A  AG+WPLKWYAPECIY+ +F SKSDVWSYGITLWE  SYG RPY+ L G  IL  ++ G RL  P   P  +Y +M  CW  +   RP+F ++
Sbjct:   18 TFELKMENLSLGKELGHGNFGSVLKGTYKMPNGERIPVAVKSLKSDDINNPKS-EILHEARVMMELDHPYIVRIIGMCQGPSMMLVMELAGEGPLNKYLKKNKGMPLLNILVLMLQVAEGMQYLESLQFVHRDLAARNVLVVNDSFVKISDFGMSRAMGAGSDYYKAGTAGRWPLKWYAPECIYFRKFSSKSDVWSYGITLWEATSYGARPYQSLSGQAILEKIESGYRLPAPAKLPSCVYQLMKDCWQWEQDDRPSFMQI 277

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO49804 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFY7])

HSP 1 Score: 187.963 bits (476), Expect = 2.461e-54
Identity = 91/215 (42.33%), Postives = 137/215 (63.72%), Query Frame = 2

Query: 1625 TIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQ-SLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCW 2266
            TIPVAVKM+K    S+    + +EEA+ M Q +H ++V+L G+C  + I +I EL   G +  YLR++Q  L    + E++ QV+  M YLE+  F+HRDLAARN L+      K++DFG+++ +    D Y A+   K+P+KW APE I Y +F SKSDVW++GI  WEV++ G++PY     T ++ M+  G RL+KP+ CP++ Y  M +CW
Sbjct:    5 TIPVAVKMMKDGAMSE---EDFIEEAKVMKQFQHGNLVQLYGICSEKPIYIIQELMKGGCLLHYLRKSQFKLQSAEMTEMVRQVAAAMKYLESHNFIHRDLAARNCLIGENRTVKVADFGLARYVI--DDEYTASEGTKFPIKWAAPEVILYSKFSSKSDVWAFGILAWEVYTGGKQPYPATNNTDVVQMVINGYRLEKPLRCPDAAYSTMRKCW 214

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47802 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL50])

HSP 1 Score: 190.66 bits (483), Expect = 8.888e-53
Identity = 102/248 (41.13%), Postives = 146/248 (58.87%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKI--GAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRN-QSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQ--GQRLKKPINCPESIYDVMLQ-CWSTDGVRRPTFAELVMTMSRIQVGLSTGIH 2353
            + VAVK LK    +       + ++EA +M+ L H HI+RL G+     ++L+ ELAPLG +   LR N Q     +L + M QV+ GMAYLE+ +F+HRDLAARNVLL +    KI DFG+ +AL+   DYY     GK P  W  PE + Y +F   SDVWS+GI + E+FSYGE P+  L G QIL+ +D    +R  KP +CP  IY +++  CW+ D   R  F+EL  ++ +++      +H
Sbjct:  143 VDVAVKCLKFSADAAFIQMQTDFIKEANSMALLDHPHIIRLFGIVLSTPMMLVTELAPLGCLLTALRNNRQRFMVSTLCDFMIQVASGMAYLESKRFIHRDLAARNVLLESNEKVKIGDFGLMRALSVEDDYYTMNPKGKVPFAWCPPEALKYRKFSHASDVWSFGICVIELFSYGEEPWPGLNGAQILAKVDMPLCERPLKPSHCPSLIYSLLVSLCWAHDPSNRAGFSELKKSLEQVRPHDVRAVH 390

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8])

HSP 1 Score: 184.496 bits (467), Expect = 6.662e-51
Identity = 94/232 (40.52%), Postives = 141/232 (60.78%), Query Frame = 2

Query: 1625 TIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVC-KCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQ---VSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELV 2308
            TIPVA+K LK+   SK    + + EA  M Q    +++ L GV  K   ++++ E    G ++ +L++  S  + SLI+LM     ++ GM YL    FVHRDLAARN+L+      K++DFG+S+ L   +D     + GK P++W APE I Y +F + SDVWSYGI LWE FS+ ERPY D    +++  ++ G RL  P++CP+ I+ +ML+CW  D  +RP+FA +V
Sbjct:   84 TIPVAIKTLKQGSTSK-NRGDFLSEASVMGQFCDPNVIFLEGVVSKTHPLMIVTEFMSNGSLDNFLKKMDS--KLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSREL---EDSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPPMSCPKVIHQIMLECWDADRTKRPSFALIV 309

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO37886 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEI8])

HSP 1 Score: 179.874 bits (455), Expect = 1.828e-50
Identity = 102/254 (40.16%), Postives = 151/254 (59.45%), Query Frame = 2

Query: 1622 ETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQL-RHKHIVRLIGVC-KCEQILLILELAPLGPINKYLRRNQSLSE----------QSLIELMSQV------SRGMAYLEASKFVHRDLAARNVLLVNEHYA-KISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRI 2326
            E   VAVKMLK E  S+    ++  E + M  L  HK+I+ L+G C + E ++LILE A  G + ++LR  + + E          ++   L  QV      ++GM +L + K +HRDLAARNVL V+E YA KI DFG+++ + Y  D Y    AG  P+KW APE ++   + SK+DVW++G+ LWE+ + G  PY  +   Q+L  +++G+R+ +P +CP  IY +M  CWS +  RRPTFAELV  + RI
Sbjct:   48 EATTVAVKMLK-ENASESDYKDLASELKIMIHLGEHKNIINLLGACTRGENLMLILEYAKHGNLLQFLRTRRDIYEPTWKKTTFNPKTEFTLADQVVDAYQIAQGMDFLASKKCIHRDLAARNVL-VDEGYALKIGDFGLARDI-YKTDLYVKKGAGLLPVKWMAPEALFDREYSSKTDVWAFGVVLWEILTLGGSPYPGVPLEQLLDYINEGKRMAQPRDCPPEIYAIMCDCWSLEQDRRPTFAELVRRIERI 298

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: syk (spleen associated tyrosine kinase [Source:NCBI gene;Acc:101155127])

HSP 1 Score: 283.878 bits (725), Expect = 3.059e-84
Identity = 121/223 (54.26%), Postives = 171/223 (76.68%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + ++     E++ EA  M QL + +IVR+IG+C+ E ++L++ELA LGP+NK+L++N+  S +++ EL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKA+    +YY+A   GKWP+KWYAPECI YF+F SKSDVWS+G+ +WE FSYG++PYK +KG  ++ ML+ G+R++ P+ CP+ +Y++ML CW+     RP+FA
Sbjct:  340 PVAVKILKNDDNNPSVREEMLREASVMQQLDNPYIVRMIGICEAENLMLVMELADLGPLNKFLQKNKHASTKNITELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKAIAEEHNYYKAKGHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNDVMQMLEGGRRMEAPVGCPQEMYEMMLSCWTYKVDERPSFA 562

HSP 2 Score: 127.102 bits (318), Expect = 5.051e-30
Identity = 79/247 (31.98%), Postives = 134/247 (54.25%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDS-----SSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F+G I R+ AED L   G   G++LLR+S N  G + +S+ +     HY IEK+ + T+ I  G+ +  P+++++HH    DG + L + P  R P           K   FED +K+K +    K +     +++E+ +    R  L+ ++    H S PWFH  + R E+  RL++     G+FL+RQR  +  + L +  + +  HY+I  ++ DKL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   10 FFYGNIAREEAEDYLRQAGMSNGLYLLRQSRNYLGGFALSVANAKHCYHYTIEKKPNETYAIAGGKSYRSPVDVIDHHSQETDGLVCLLKKPCNR-PKNMQ------PKVGPFED-LKEKLIREYVKQTWNLRGAALEQAIIS-QRPQLEKLIATTAHESMPWFHGAISREESAARLQSGSRNNGKFLIRQRNENGSYALCLLHEGEVIHYRIDRDRKDKLSIPDGKQFDTLWQLVEHYSYKPDGLL 247

HSP 3 Score: 56.225 bits (134), Expect = 1.335e-7
Identity = 31/94 (32.98%), Postives = 49/94 (52.13%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+R+ +   L S     G FL+R+ + NG+Y + + H  +V HY I++       I  G++F    +LVEH+    DG L +   P  R
Sbjct:  163 WFHGAISREESAARLQSGSRNNGKFLIRQRNENGSYALCLLHEGEVIHYRIDRDRKDKLSIPDGKQFDTLWQLVEHYSYKPDGLLRVLTEPSPR 256

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: syk (spleen associated tyrosine kinase [Source:NCBI gene;Acc:101155127])

HSP 1 Score: 284.263 bits (726), Expect = 4.311e-84
Identity = 121/223 (54.26%), Postives = 171/223 (76.68%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + ++     E++ EA  M QL + +IVR+IG+C+ E ++L++ELA LGP+NK+L++N+  S +++ EL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKA+    +YY+A   GKWP+KWYAPECI YF+F SKSDVWS+G+ +WE FSYG++PYK +KG  ++ ML+ G+R++ P+ CP+ +Y++ML CW+     RP+FA
Sbjct:  366 PVAVKILKNDDNNPSVREEMLREASVMQQLDNPYIVRMIGICEAENLMLVMELADLGPLNKFLQKNKHASTKNITELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKAIAEEHNYYKAKGHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNDVMQMLEGGRRMEAPVGCPQEMYEMMLSCWTYKVDERPSFA 588

HSP 2 Score: 127.872 bits (320), Expect = 4.219e-30
Identity = 79/247 (31.98%), Postives = 134/247 (54.25%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDS-----SSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F+G I R+ AED L   G   G++LLR+S N  G + +S+ +     HY IEK+ + T+ I  G+ +  P+++++HH    DG + L + P  R P           K   FED +K+K +    K +     +++E+ +    R  L+ ++    H S PWFH  + R E+  RL++     G+FL+RQR  +  + L +  + +  HY+I  ++ DKL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   10 FFYGNIAREEAEDYLRQAGMSNGLYLLRQSRNYLGGFALSVANAKHCYHYTIEKKPNETYAIAGGKSYRSPVDVIDHHSQETDGLVCLLKKPCNR-PKNMQ------PKVGPFED-LKEKLIREYVKQTWNLRGAALEQAIIS-QRPQLEKLIATTAHESMPWFHGAISREESAARLQSGSRNNGKFLIRQRNENGSYALCLLHEGEVIHYRIDRDRKDKLSIPDGKQFDTLWQLVEHYSYKPDGLL 247

HSP 3 Score: 56.6102 bits (135), Expect = 1.206e-7
Identity = 31/94 (32.98%), Postives = 49/94 (52.13%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+R+ +   L S     G FL+R+ + NG+Y + + H  +V HY I++       I  G++F    +LVEH+    DG L +   P  R
Sbjct:  163 WFHGAISREESAARLQSGSRNNGKFLIRQRNENGSYALCLLHEGEVIHYRIDRDRKDKLSIPDGKQFDTLWQLVEHYSYKPDGLLRVLTEPSPR 256

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: syk (spleen associated tyrosine kinase [Source:NCBI gene;Acc:101155127])

HSP 1 Score: 283.878 bits (725), Expect = 7.402e-84
Identity = 121/223 (54.26%), Postives = 171/223 (76.68%), Query Frame = 2

Query: 1631 PVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA 2299
            PVAVK+LK + ++     E++ EA  M QL + +IVR+IG+C+ E ++L++ELA LGP+NK+L++N+  S +++ EL+ QVS GM YLE   FVHRDLAARNVLLV +HYAKISDFG+SKA+    +YY+A   GKWP+KWYAPECI YF+F SKSDVWS+G+ +WE FSYG++PYK +KG  ++ ML+ G+R++ P+ CP+ +Y++ML CW+     RP+FA
Sbjct:  387 PVAVKILKNDDNNPSVREEMLREASVMQQLDNPYIVRMIGICEAENLMLVMELADLGPLNKFLQKNKHASTKNITELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKAIAEEHNYYKAKGHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNDVMQMLEGGRRMEAPVGCPQEMYEMMLSCWTYKVDERPSFA 609

HSP 2 Score: 127.487 bits (319), Expect = 6.682e-30
Identity = 79/247 (31.98%), Postives = 134/247 (54.25%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDS-----SSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKI-INKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL 799
            +F+G I R+ AED L   G   G++LLR+S N  G + +S+ +     HY IEK+ + T+ I  G+ +  P+++++HH    DG + L + P  R P           K   FED +K+K +    K +     +++E+ +    R  L+ ++    H S PWFH  + R E+  RL++     G+FL+RQR  +  + L +  + +  HY+I  ++ DKL I  G+ FD+L +L++HY ++ DGLL
Sbjct:   10 FFYGNIAREEAEDYLRQAGMSNGLYLLRQSRNYLGGFALSVANAKHCYHYTIEKKPNETYAIAGGKSYRSPVDVIDHHSQETDGLVCLLKKPCNR-PKNMQ------PKVGPFED-LKEKLIREYVKQTWNLRGAALEQAIIS-QRPQLEKLIATTAHESMPWFHGAISREESAARLQSGSRNNGKFLIRQRNENGSYALCLLHEGEVIHYRIDRDRKDKLSIPDGKQFDTLWQLVEHYSYKPDGLL 247

HSP 3 Score: 56.225 bits (134), Expect = 1.434e-7
Identity = 31/94 (32.98%), Postives = 49/94 (52.13%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRE-SVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLER 361
            +FHG I+R+ +   L S     G FL+R+ + NG+Y + + H  +V HY I++       I  G++F    +LVEH+    DG L +   P  R
Sbjct:  163 WFHGAISREESAARLQSGSRNNGKFLIRQRNENGSYALCLLHEGEVIHYRIDRDRKDKLSIPDGKQFDTLWQLVEHYSYKPDGLLRVLTEPSPR 256

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: zap70 (tyrosine-protein kinase ZAP-70 [Source:NCBI gene;Acc:101170171])

HSP 1 Score: 263.077 bits (671), Expect = 1.748e-76
Identity = 117/240 (48.75%), Postives = 171/240 (71.25%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLR-RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLST 2344
            + VAVK+LK E + K+   E+M EA  M QL +  IVR++G+C+ + ++L++E+A  GP+NK+L  +   ++ ++++ L+ QVS GM YLE   FVHRDLAARNVLLVN+ +AKISDFG+SKAL    +YY+A  AGKWPLKWYAPECI + +F SKSDVWS+G+T+WE F+YG +PYK +KG +++S +  G R++KP  CP+ +Y VM++CW+     RP F ++  +M      +S 
Sbjct:  342 VDVAVKVLKSE-NEKLVKDEMMREAEIMHQLSNPFIVRMLGLCQGDNLMLVMEMAAAGPLNKFLSTKKDVITVENIVNLLHQVSMGMKYLEEKNFVHRDLAARNVLLVNQQFAKISDFGLSKALGADDNYYKARTAGKWPLKWYAPECINFHKFSSKSDVWSFGVTMWEAFTYGGKPYKKMKGPEVISFIKNGNRMEKPPACPDRMYAVMMECWTYSHEERPDFKKVEESMRTYHYSISN 580

HSP 2 Score: 110.923 bits (276), Expect = 9.311e-25
Identity = 86/270 (31.85%), Postives = 137/270 (50.74%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECP-GFIRSKAEFLQSLNQSS 880
            +F+G I+R  AE  L   G  +G+FLLR  +   G YV+S+    + +HY+IEKQ +GT+ I  G+   GP EL E +    DG + + R P  R P   +  I  GV      + +++   +    +  ++E+ +     Q L+ ++    H   PWFH  + R E E RL +    +G+FLVR+R     F LS+       HY+I+ +K  KL +  G  FD+L +L+++   + DGL+  L  G  C  G +  + E   SLN+ S
Sbjct:   11 FFYGSISRSDAEQQLKLGGMADGLFLLRHCLRNLGGYVLSVVWNLEFHHYSIEKQLNGTYCIAGGKPHCGPAELCEFYSKDPDGLVCILRKPCLRPP---NTPIKMGVFDKIRVNMLREYVRQTWNLEGEAMEQAIISQAPQ-LEKLIATTAHEKMPWFHGKINRHEGERRLYSGAQPDGKFLVRERDEPGTFALSVVYGKTVYHYQIVQDKSGKLSVPEGTKFDTLWQLVEYLKMKPDGLVIVL--GEACTNGRVSERTEPF-SLNRRS 273

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: zap70 (tyrosine-protein kinase ZAP-70 [Source:NCBI gene;Acc:101170171])

HSP 1 Score: 263.077 bits (671), Expect = 9.292e-76
Identity = 117/239 (48.95%), Postives = 171/239 (71.55%), Query Frame = 2

Query: 1628 IPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLR-RNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLS 2341
            + VAVK+LK E + K+   E+M EA  M QL +  IVR++G+C+ + ++L++E+A  GP+NK+L  +   ++ ++++ L+ QVS GM YLE   FVHRDLAARNVLLVN+ +AKISDFG+SKAL    +YY+A  AGKWPLKWYAPECI + +F SKSDVWS+G+T+WE F+YG +PYK +KG +++S +  G R++KP  CP+ +Y VM++CW+     RP F ++  +M      +S
Sbjct:  417 VDVAVKVLKSE-NEKLVKDEMMREAEIMHQLSNPFIVRMLGLCQGDNLMLVMEMAAAGPLNKFLSTKKDVITVENIVNLLHQVSMGMKYLEEKNFVHRDLAARNVLLVNQQFAKISDFGLSKALGADDNYYKARTAGKWPLKWYAPECINFHKFSSKSDVWSFGVTMWEAFTYGGKPYKKMKGPEVISFIKNGNRMEKPPACPDRMYAVMMECWTYSHEERPDFKKVEESMRTYHYSIS 654

HSP 2 Score: 111.694 bits (278), Expect = 8.644e-25
Identity = 78/245 (31.84%), Postives = 126/245 (51.43%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN--GNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKII-NKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKL 808
            +F+G I+R  AE  L   G  +G+FLLR  +   G YV+S+    + +HY+IEKQ +GT+ I  G+   GP EL E +    DG + + R P  R P   +  I  GV      + +++   +    +  ++E+ +     Q L+ ++    H   PWFH  + R E E RL +    +G+FLVR+R     F LS+       HY+I+ +K  KL +  G  FD+L +L+++   + DGL+  L
Sbjct:   86 FFYGSISRSDAEQQLKLGGMADGLFLLRHCLRNLGGYVLSVVWNLEFHHYSIEKQLNGTYCIAGGKPHCGPAELCEFYSKDPDGLVCILRKPCLRPP---NTPIKMGVFDKIRVNMLREYVRQTWNLEGEAMEQAIISQAPQ-LEKLIATTAHEKMPWFHGKINRHEGERRLYSGAQPDGKFLVRERDEPGTFALSVVYGKTVYHYQIVQDKSGKLSVPEGTKFDTLWQLVEYLKMKPDGLVIVL 326

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000064511.1 (SMESG000064511.1)

HSP 1 Score: 1614.36 bits (4179), Expect = 0.000e+0
Identity = 810/826 (98.06%), Postives = 810/826 (98.06%), Query Frame = 2

Query:   50 MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNEPVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPSPPISLKENEIWSKESVSTNNREFGDW 2527
            MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFLRRLEAEERLENAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNEPVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLGGGNFGYVYGGFYKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSR               AARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPSPPISLKENEIWSKESVSTNN EFGDW
Sbjct:    1 MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFLRRLEAEERLENAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNEPVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLGGGNFGYVYGGFYKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSR---------------AARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPSPPISLKENEIWSKESVSTNNHEFGDW 811

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000064511.1 (SMESG000064511.1)

HSP 1 Score: 1598.56 bits (4138), Expect = 0.000e+0
Identity = 809/845 (95.74%), Postives = 810/845 (95.86%), Query Frame = 2

Query:   50 MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNEPVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEI-------------------ASSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPSPPISLKENEIWSKESVSTNNREFGDW 2527
            MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFLRRLEAEERLENAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNEPVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEI                   +SSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLGGGNFGYVYGGFYKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSR               AARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPSPPISLKENEIWSKESVSTNN EFGDW
Sbjct:    1 MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFLRRLEAEERLENAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNEPVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIVCKFFKSANFPVREFSGYHSSSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLGGGNFGYVYGGFYKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSR---------------AARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPSPPISLKENEIWSKESVSTNNHEFGDW 830

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000043611.1 (SMESG000043611.1)

HSP 1 Score: 754.977 bits (1948), Expect = 0.000e+0
Identity = 426/861 (49.48%), Postives = 554/861 (64.34%), Query Frame = 2

Query:   50 MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISICHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARLPLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMRQHLKHMVLKDLHFSQPWFHHFXXXXXXXXXXXNAGHTEGQFLVRQRKGDCGFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLLCKLRFGIECPGF--IRSKAEFLQSLNQSSVESAHS-TICGMQNAARIQRTAVKTDLSRIVTDKYRDMSINSIFRQK-------------KSDMISVSSDLISFSEW------------------------------STNLPRLLNEPVSASLNNL--NKEL-----------FYPNSITTKNVFQWNNS-----------ISSSTQSF-----VNDTRQT--NDTPKVSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSRQVISPSLEVEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKIEIKQKLXXXXXXXXXXXXXKI-NLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHELAEQTNYLANSSGS 2398
            M+Q  SP ++ Y+HG+ITRD+AE+LLM +G  E +FLLRESVN NY +SIC  N+V+HYNIE+Q DGT+QI TGR+FIGP+ELV+HH  HLDGFLTLAR PLERYP G SY++LQGV +S  E+ ++ KA++MG K ++SIEE L GPMR+HLK +VL+DLH  QPW+H  +RR ++E+RL+ AGHTEGQFLVR RK +  FVLS+S QNQPKHYKI    DK  I+GGQYF SLIE+IDHY+FRQDGLLCKLRF +E P +   RS A  + S + S   +  S  + G ++     R    T     +T +    S  S                       +  SDLISF++W                              STNLP   ++ +S  +  L  N+E            F P       +   N +           ++ S++SF     ++  R T  N +PK      T        +Q LN+P I D+ W EP++  S    +P++ +++     +  S  P      +  L    +  TQ +YDSL L+D +FN    +I IK KLGGGNFG+V+GG YK  +  + +PVA+KMLK++  S I   +IM EAR M+QL+H+HIVRLIG+C+  Q++L+LELAPLGPINKYLR+NQ ++  S+ ELM QV+ GMAYLEASKFVHRDLAARNVLLV++ YAKISDFGMSKAL +G DYYRAA AGKWP+KWYAPECIYYFRFDSKSDVWSYG+T+WEVFSYG+RPY+D+KGTQIL+M+D+G+RL KP +CP+SIYDVMLQCW  DGVRRPTFAELV+ +SRI     T         ++ +N  GS
Sbjct:    1 MTQPISPKSVNYYHGRITRDQAEELLMGRGGTESLFLLRESVNNNYAVSICFNNRVHHYNIERQIDGTYQIPTGRRFIGPVELVKHHSQHLDGFLTLARYPLERYPPGLSYFVLQGVSASDLEERLRLKAIQMGLKGTTSIEEALAGPMREHLKQLVLRDLHLCQPWYHDSIRRSDSEQRLQEAGHTEGQFLVRYRKDENNFVLSLSYQNQPKHYKINCSSDKFQIDGGQYFSSLIEMIDHYHFRQDGLLCKLRFPVESPKYQRSRSGANSITSRSLSGASTPSSLPLAGEKSTPPQLRNIKPTQQFNQITGQLPTFSSESSSESSGPASRVSNNPWGIPGPETTTPSDLISFTDWSNLSSLMNNNNVSSQQPIVTPLNIFATTPNSTNLPVFHSQMISNMIAPLHINQEKLIEASSNFSTGFTPTPTPGNCMISQNPNFNPLQNPLSIRVNQSSESFEQLSAISGGRSTGSNQSPKT-----TPHQSRTSSNQGLNQPAIMDEQWEEPDLDGSGHH-APNMRIDLPNVSPQQRSNKPHSNSCHISEL---FSEATQVVYDSLPLDDETFNFDPSQISIKDKLGGGNFGHVFGGIYKPSDGKKEVPVAIKMLKQDQMSNIIEDDIMAEARVMAQLKHRHIVRLIGICRDAQVMLVLELAPLGPINKYLRKNQEMNYISITELMYQVALGMAYLEASKFVHRDLAARNVLLVSDKYAKISDFGMSKALKFGNDYYRAANAGKWPIKWYAPECIYYFRFDSKSDVWSYGVTMWEVFSYGDRPYRDMKGTQILAMIDRGKRLSKPHSCPDSIYDVMLQCWEFDGVRRPTFAELVLIISRILNNFHTSAGTKIGNNSFHSNQFGS 852

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000016930.1 (SMESG000016930.1)

HSP 1 Score: 205.297 bits (521), Expect = 7.020e-56
Identity = 98/229 (42.79%), Postives = 142/229 (62.01%), Query Frame = 2

Query: 1622 ETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSE-QSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAEL 2305
            +T  VAVK LK    +K    E ++EAR M +L H ++VRL  VC  E I ++ EL   G + +YLR     +E + L+++MSQ++ GMAYLE   ++HRDLAARN+L+   +  KI+DFG+++ +    D Y A    K+P+KW APE     +F  KSDVWSYGI L+E+ ++G+ P+  +  TQ L  +++G R+ KP NCP+ +Y VML CW      RPTF  L
Sbjct:  381 KTTDVAVKTLKPGTMAK---EEFLKEARIMKRLNHSNLVRLYAVCSDEPIYIVTELMTKGSLLEYLREEGKHTELKELMDMMSQIANGMAYLEKEGYIHRDLAARNILIGENNICKIADFGLTRVIQGSSDTYNARQGAKFPIKWTAPEAALMGKFTVKSDVWSYGIVLYEIITHGQTPFPAMNNTQTLQQVEKGYRMPKPSNCPQELYKVMLYCWEALPENRPTFKYL 606

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000051839.1 (SMESG000051839.1)

HSP 1 Score: 203.756 bits (517), Expect = 2.422e-54
Identity = 124/325 (38.15%), Postives = 183/325 (56.31%), Query Frame = 2

Query: 1388 VEISRNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNL-PIDKIEIKQKLXXXXXXXXXXXXXKINLLETIPVAVKMLKKEMHSKIGAHEIMEEARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYL-RRNQSLSEQSLIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALNYGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFAELVMTMSRIQVGLSTGIHE 2356
            V  +RN   SS+ PP+           M +  +  ++  ++ N+    + P D + +  +LG G FG VY G   ++  +   VAVK+L +         + M+EA  M QL H +I+ + GVC+ +++++ILE+A LG +  YL    + +    L     Q++ GM YLE+  FVHRDLA RNVLL +E   KISDFG+S+A+    DYY+A   GKWP+KWYAPE IYY  F   SDVWSYG+ LWE++S GE PY      ++L  +++G RL +P    + +Y +M QCW+     RPTF+ L+   S     L T I+E
Sbjct:  495 VRANRNHNTSSTNPPR-----------MSSSSSSGVWSQMANNNSEIRMIPSDAVILLYRLGEGEFGEVYRGRLHLDNGQMEEVAVKVLVQPSQRL----DFMKEASIMMQLSHPNIITMYGVCENKRLMMILEVANLGSLLDYLLDYPEKIQLSDLHNWAMQIASGMTYLESKGFVHRDLACRNVLLSSESCCKISDFGLSRAVGVESDYYKATRRGKWPVKWYAPESIYYKTFSHASDVWSYGVCLWEMWSLGEHPYAQQDSFEVLRQIEEGVRLPRPKLTSDKVYMLMQQCWAYRPEDRPTFSHLLAVFSH----LCTNIYE 800

HSP 2 Score: 51.2174 bits (121), Expect = 4.413e-6
Identity = 28/70 (40.00%), Postives = 44/70 (62.86%), Query Frame = 2

Query:   83 YFHGKITRDRAEDLLMSQGAIEGMFLLRESVN-GNYVISICHCNKVNHYNIEKQSDGTFQI-LTGRKFIG 286
            ++HG I+R+  E LL  Q A  G FL+R S++ G YV+S+    ++ HY IE+  DG +Q+  T  K++G
Sbjct:   69 WYHGNISREDTERLLKHQSA-NGTFLIRYSISTGKYVLSVIFNQQIYHYPIEELPDGFYQVNGTNSKYLG 137

The following BLAST results are available for this feature:

BLAST of Tyrosine-protein kinase vs. Ensembl Human
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
BLAST of Tyrosine-protein kinase vs. TrEMBL
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
BLAST of Tyrosine-protein kinase vs. Planmine SMEST

BLAST of Tyrosine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SYK	4.716e-81	52.68	spleen associated tyrosine kinase [Source:HGNC Sym...	[more]
SYK	4.716e-81	52.68	spleen associated tyrosine kinase [Source:HGNC Sym...	[more]
SYK	8.691e-81	52.68	spleen associated tyrosine kinase [Source:HGNC Sym...	[more]
SYK	8.691e-81	52.68	spleen associated tyrosine kinase [Source:HGNC Sym...	[more]
ZAP70	4.441e-77	49.59	zeta chain of T cell receptor associated protein k...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ark-1	3.860e-53	44.39	Ack-related non-receptor tyrosine kinase [Source:...	[more]
ark-1	4.390e-53	44.39	Ack-related non-receptor tyrosine kinase [Source:...	[more]
src-2	1.254e-50	40.97	Tyrosine protein-kinase src-2 [Source:UniProtKB/S...	[more]
abl-1	3.754e-50	40.17	Tyrosine-protein kinase abl-1 [Source:UniProtKB/S...	[more]
abl-1	4.187e-50	40.17	Tyrosine-protein kinase abl-1 [Source:UniProtKB/S...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Shark	9.025e-57	44.83	gene:FBgn0015295 transcript:FBtr0087244	[more]
Src42A	3.592e-53	40.52	gene:FBgn0264959 transcript:FBtr0335275	[more]
Src42A	8.851e-52	40.52	gene:FBgn0264959 transcript:FBtr0335276	[more]
Ack-like	6.015e-51	43.15	gene:FBgn0263998 transcript:FBtr0330329	[more]
Ack-like	6.074e-51	43.15	gene:FBgn0263998 transcript:FBtr0330331	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
syk	1.559e-81	53.15	spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
syk	1.559e-81	53.15	spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
syk	2.645e-81	53.15	spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
zap70	7.324e-77	47.67	zeta chain of T cell receptor associated protein k...	[more]
si:ch73-383l1.1	3.720e-55	41.88	si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-6...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
zap70	9.875e-77	54.91	zeta chain of T cell receptor associated protein k...	[more]
galk1	2.217e-76	50.67	galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127...	[more]
galk1	2.220e-76	50.67	galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127...	[more]
galk1	5.654e-76	50.67	galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127...	[more]
galk1	7.621e-76	50.67	galactokinase 1 [Source:Xenbase;Acc:XB-GENE-969127...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Syk	2.012e-80	52.23	spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:...	[more]
Syk	2.012e-80	52.23	spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:...	[more]
Syk	2.607e-78	54.33	spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:...	[more]
Zap70	1.869e-73	50.42	zeta-chain (TCR) associated protein kinase [Source...	[more]
Erbb4	1.534e-52	41.45	erb-b2 receptor tyrosine kinase 4 [Source:MGI Symb...	[more]

BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q64725\|KSYK_RAT	2.349e-80	52.68	Tyrosine-protein kinase SYK OS=Rattus norvegicus O...	[more]
sp\|P43405\|KSYK_HUMAN	4.174e-80	52.68	Tyrosine-protein kinase SYK OS=Homo sapiens OX=960...	[more]
sp\|F1N9Y5\|KSYK_CHICK	6.583e-80	51.09	Tyrosine-protein kinase SYK OS=Gallus gallus OX=90...	[more]
sp\|P48025\|KSYK_MOUSE	1.408e-79	52.23	Tyrosine-protein kinase SYK OS=Mus musculus OX=100...	[more]
sp\|Q00655\|KSYK_PIG	5.823e-78	51.34	Tyrosine-protein kinase SYK OS=Sus scrofa OX=9823 ...	[more]

BLAST of Tyrosine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A5K3ELS1	6.076e-125	52.10	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A158QUA3	9.766e-122	52.10	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A183MH92	1.322e-120	68.57	Protein kinase domain-containing protein OS=Schist...	[more]
G4VKS4	2.802e-120	68.21	Tyrosine kinase OS=Schistosoma mansoni OX=6183 GN=...	[more]
A0A0X3P5I8	7.000e-120	65.95	Tyrosine-protein kinase SYK (Fragment) OS=Schistoc...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
zap70	8.245e-81	53.68	tyrosine-protein kinase ZAP-70 [Source:NCBI gene;A...	[more]
zap70	1.366e-80	53.68	tyrosine-protein kinase ZAP-70 [Source:NCBI gene;A...	[more]
zap70	1.366e-80	53.68	tyrosine-protein kinase ZAP-70 [Source:NCBI gene;A...	[more]
syk	1.048e-72	49.33	spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
syk	1.124e-72	49.54	spleen tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-0...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000006670.1	3.010e-55	40.52	pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene...	[more]
ENSPMAT00000003172.1	3.363e-52	40.60	pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 ge...	[more]
frk	7.263e-52	41.23	fyn-related Src family tyrosine kinase [Source:ZFI...	[more]
ENSPMAT00000001705.1	5.879e-50	36.67	pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 ge...	[more]
frk	8.667e-50	39.83	fyn-related Src family tyrosine kinase [Source:ZFI...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
BCK1	3.535e-18	29.36	MAPKKK acting in the protein kinase C signaling pa...	[more]
CDC15	8.275e-18	27.31	Protein kinase of the Mitotic Exit Network; locali...	[more]
STE11	1.052e-15	24.20	Signal transducing MEK kinase; involved in pheromo...	[more]
KIN2	3.610e-15	25.00	Serine/threonine protein kinase involved in regula...	[more]
TPK2	3.638e-14	25.11	cAMP-dependent protein kinase catalytic subunit; p...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO31298	1.243e-82	51.34	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49804	2.461e-54	42.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47802	8.888e-53	41.13	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40994	6.662e-51	40.52	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37886	1.828e-50	40.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
syk	3.059e-84	54.26	spleen associated tyrosine kinase [Source:NCBI gen...	[more]
syk	4.311e-84	54.26	spleen associated tyrosine kinase [Source:NCBI gen...	[more]
syk	7.402e-84	54.26	spleen associated tyrosine kinase [Source:NCBI gen...	[more]
zap70	1.748e-76	48.75	tyrosine-protein kinase ZAP-70 [Source:NCBI gene;A...	[more]
zap70	9.292e-76	48.95	tyrosine-protein kinase ZAP-70 [Source:NCBI gene;A...	[more]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000064511.1	0.000e+0	98.06	SMESG000064511.1	[more]
SMESG000064511.1	0.000e+0	95.74	SMESG000064511.1	[more]
SMESG000043611.1	0.000e+0	49.48	SMESG000043611.1	[more]
SMESG000016930.1	7.020e-56	42.79	SMESG000016930.1	[more]
SMESG000051839.1	2.422e-54	38.15	SMESG000051839.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30003048 ID=SMED30003048|Name=Tyrosine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2905bp
ATGAAATAATTATGATTAATTGTATACAAATGTAAACAATTCAATAATTA
TGTCTCAAGGCAAATCACCCTTTAATATTCTTTATTTCCATGGAAAAATT
ACTAGAGATCGGGCGGAAGATTTATTGATGAGCCAAGGAGCAATCGAAGG
AATGTTTCTTCTACGTGAAAGTGTTAATGGGAATTACGTAATATCTATTT
GTCACTGTAATAAAGTAAACCATTATAACATTGAAAAACAAAGTGATGGA
ACTTTTCAAATTTTAACCGGAAGAAAATTTATTGGTCCAATTGAGCTTGT
TGAACATCACATGTTACATCTTGATGGGTTTTTGACTCTAGCCAGATTAC
CTCTTGAAAGATATCCTGCTGGAACTTCATATTATATCTTGCAAGGAGTC
AAATCATCTTTTTTTGAGGATTGTATCAAGAAAAAGGCATTAGAAATGGG
CTTTAAAGATTCAAGCAGTATTGAAGAAGTTCTCAATGGACCGATGAGAC
AGCACTTAAAGCATATGGTTCTCAAAGATCTTCATTTCTCTCAGCCTTGG
TTTCATCATTTTCTTAGGCGTTTAGAAGCGGAAGAAAGACTAGAAAATGC
AGGTCATACAGAAGGTCAATTTCTCGTCCGGCAAAGAAAAGGTGATTGTG
GATTTGTGTTGAGTATCAGCGTGCAAAATCAACCAAAGCACTATAAAATC
ATTAATAAATTTGACAAGCTCCATATCGAAGGTGGACAATATTTTGACTC
CCTAATTGAGTTGATCGATCATTATTATTTCCGCCAAGATGGATTGCTGT
GTAAATTGAGATTCGGAATTGAATGTCCGGGATTCATACGATCGAAAGCT
GAATTTTTGCAATCATTGAACCAATCAAGTGTTGAAAGTGCTCATTCGAC
CATTTGTGGAATGCAAAACGCAGCGAGAATTCAAAGAACAGCCGTAAAGA
CGGATTTATCGAGAATTGTTACGGACAAATACAGAGATATGAGCATTAAT
TCAATTTTCAGACAGAAAAAGTCCGACATGATTTCCGTGTCTAGCGATTT
GATCAGTTTCAGTGAGTGGTCGACGAATCTCCCTCGGCTATTAAATGAGC
CGGTCTCTGCATCATTGAACAATCTCAACAAGGAATTATTTTATCCAAAT
TCTATCACAACCAAAAACGTCTTCCAATGGAATAACAGTATCAGTTCTTC
CACCCAATCATTTGTCAACGACACCCGTCAAACCAATGATACACCAAAGG
TATCAGAGAATGTTATTACACTCGAATACAAAGATAATATTCTTGATCAA
AGTTTGAATGAACCTCAAATTACAGATCAGTTATGGTCAGAACCTGAAAT
AGCTTCATCACGTCAAGTTATTTCTCCATCACTGGAAGTTGAAATTTCCA
GAAATCGAATCAAATCGTCATCAATGCCTCCAAAACTTCAGCCATGGGAC
TTAGGAATATTAGATCCAATGTTGGCTGTTGAAACTCAAAAAATATACGA
TTCTTTATCACTAAATGATATTTCGTTCAACTTACCAATTGATAAAATTG
AAATTAAACAAAAGCTCGGAGGTGGAAATTTCGGATATGTTTATGGAGGA
TTTTATAAAATCAATTTGCTTGAAACGATTCCAGTGGCTGTCAAAATGCT
AAAGAAGGAAATGCATTCCAAAATTGGAGCACACGAAATTATGGAAGAGG
CACGAACAATGTCACAACTGCGTCATAAACATATCGTTAGGTTAATTGGA
GTATGTAAATGTGAGCAGATACTCCTCATCTTGGAGTTAGCTCCATTGGG
ACCAATAAACAAATACTTGAGACGCAATCAATCTCTTTCTGAACAGTCTT
TAATTGAATTAATGAGTCAAGTTTCTAGAGGTATGGCCTATTTAGAAGCA
TCGAAGTTTGTACATAGAGATTTAGCAGCTCGAAATGTGTTACTGGTTAA
TGAGCATTACGCCAAAATCAGTGACTTTGGAATGAGCAAAGCTCTTAATT
ACGGCCAGGATTACTATAGGGCAGCTGCAGCAGGAAAGTGGCCTTTGAAA
TGGTATGCTCCGGAATGCATTTATTACTTCAGATTTGATAGCAAATCTGA
CGTATGGAGTTATGGAATCACTCTATGGGAAGTATTCTCCTACGGAGAAA
GACCATATAAGGATCTGAAAGGCACTCAAATATTATCGATGTTAGATCAA
GGCCAAAGACTTAAAAAACCAATTAATTGTCCAGAATCCATATACGACGT
CATGTTGCAGTGCTGGAGTACTGATGGAGTGCGAAGACCAACTTTTGCAG
AGTTGGTGATGACAATGTCAAGAATCCAAGTTGGACTTTCAACTGGAATT
CATGAACTTGCGGAACAAACAAATTATTTGGCTAATTCTAGTGGTAGCAG
TGTGGCTAAAACGTCTTATGGATCAAGCGAATGCTCGCAGTTTCCTTCTC
CTCCTATATCACTGAAAGAAAACGAGATATGGAGCAAAGAATCAGTTTCT
ACAAATAACCGTGAGTTTGGCGATTGGTAAAATCGAAAAATATTCATATT
TCATCAAGAGTGCAATACTTATTTAGTCATCATAGATTCAAATATATTAT
TTTCTTGGTTCAAATTTTGTTTAAATATTTACTGTACATCGCCCAATGCC
ATCTGGAGAGGAAGAAAGGAAGGAGAGGGAACTTGTCTCTACCTAAGTTT
TGAAAAAAACAGATTTAAAGTATCCTCAGTTAAACATATATGCATTATGT
TATACAGCACAGTAAAACGTTGTATGATAAATTGCCTTTTATGACAAATC
GTCGTTATCGAAATTATTTTTTTATAAATCAGAAGTCAGCTAAATTTCCT
ATTTTAGTGATTTTTTGTCGAACATTTTCAATTAATAAATACTGTGGAAA
AAGAC

protein sequence of SMED30003048-orf-1

>SMED30003048-orf-1 ID=SMED30003048-orf-1|Name=SMED30003048-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=827bp
MSQGKSPFNILYFHGKITRDRAEDLLMSQGAIEGMFLLRESVNGNYVISI
CHCNKVNHYNIEKQSDGTFQILTGRKFIGPIELVEHHMLHLDGFLTLARL
PLERYPAGTSYYILQGVKSSFFEDCIKKKALEMGFKDSSSIEEVLNGPMR
QHLKHMVLKDLHFSQPWFHHFLRRLEAEERLENAGHTEGQFLVRQRKGDC
GFVLSISVQNQPKHYKIINKFDKLHIEGGQYFDSLIELIDHYYFRQDGLL
CKLRFGIECPGFIRSKAEFLQSLNQSSVESAHSTICGMQNAARIQRTAVK
TDLSRIVTDKYRDMSINSIFRQKKSDMISVSSDLISFSEWSTNLPRLLNE
PVSASLNNLNKELFYPNSITTKNVFQWNNSISSSTQSFVNDTRQTNDTPK
VSENVITLEYKDNILDQSLNEPQITDQLWSEPEIASSRQVISPSLEVEIS
RNRIKSSSMPPKLQPWDLGILDPMLAVETQKIYDSLSLNDISFNLPIDKI
EIKQKLGGGNFGYVYGGFYKINLLETIPVAVKMLKKEMHSKIGAHEIMEE
ARTMSQLRHKHIVRLIGVCKCEQILLILELAPLGPINKYLRRNQSLSEQS
LIELMSQVSRGMAYLEASKFVHRDLAARNVLLVNEHYAKISDFGMSKALN
YGQDYYRAAAAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGE
RPYKDLKGTQILSMLDQGQRLKKPINCPESIYDVMLQCWSTDGVRRPTFA
ELVMTMSRIQVGLSTGIHELAEQTNYLANSSGSSVAKTSYGSSECSQFPS
PPISLKENEIWSKESVSTNNREFGDW*

Aliases

The feature 'Tyrosine-protein kinase' has the following synonyms


Synonym
syk

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000017	photoreceptor neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR036860	SH2_dom_sf
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR000980	SH2
IPR020635	Tyr_kinase_cat_dom
IPR008266	Tyr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR000719	Prot_kinase_dom
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000980	SH2 domain	PRINTS	PR00401	SH2DOMAIN	coord: 76..90 score: 29.67 coord: 12..26 score: 45.64 coord: 33..43 score: 51.8 coord: 55..65 score: 38.44
IPR000980	SH2 domain	SMART	SM00252	SH2_5	coord: 10..93 e-value: 1.6E-21 score: 87.5 coord: 165..248 e-value: 5.1E-19 score: 79.2
IPR000980	SH2 domain	PFAM	PF00017	SH2	coord: 167..242 e-value: 5.5E-15 score: 55.2 coord: 12..87 e-value: 4.8E-17 score: 61.8
IPR000980	SH2 domain	PROSITE	PS50001	SH2	coord: 167..257 score: 17.063
IPR000980	SH2 domain	PROSITE	PS50001	SH2	coord: 12..102 score: 17.908
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PRINTS	PR00109	TYRKINASE	coord: 614..632 score: 63.18 coord: 727..749 score: 45.76 coord: 578..591 score: 32.62 coord: 664..674 score: 51.89 coord: 683..705 score: 58.14
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 500..755 e-value: 4.7E-87 score: 291.5
IPR020635	Tyrosine-protein kinase, catalytic domain	SMART	SM00219	tyrkin_6	coord: 500..756 e-value: 2.6E-113 score: 392.4
None	No IPR available	PIRSF	PIRSF000615	TyrPK_CSF1-R	coord: 357..448 e-value: 170.0 score: -2.4 coord: 592..823 e-value: 1.1E-50 score: 170.3 coord: 488..600 e-value: 1.1E-8 score: 31.4
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 581..795 e-value: 6.3E-52 score: 178.1
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 487..580 e-value: 3.2E-23 score: 83.5
None	No IPR available	PANTHER	PTHR24418:SF369	TYROSINE-PROTEIN KINASE ZAP-70	coord: 10..267 coord: 484..775
None	No IPR available	PANTHER	PTHR24418	TYROSINE-PROTEIN KINASE	coord: 484..775
None	No IPR available	PANTHER	PTHR24418	TYROSINE-PROTEIN KINASE	coord: 10..267
None	No IPR available	CDD	cd00173	SH2	coord: 166..242 e-value: 2.77999E-16 score: 72.103
IPR036860	SH2 domain superfamily	GENE3D	G3DSA:3.30.505.10		coord: 157..261 e-value: 2.5E-23 score: 84.0 coord: 5..107 e-value: 2.3E-22 score: 80.8
IPR036860	SH2 domain superfamily	SUPERFAMILY	SSF55550	SH2 domain	coord: 154..255
IPR036860	SH2 domain superfamily	SUPERFAMILY	SSF55550	SH2 domain	coord: 11..104
IPR008266	Tyrosine-protein kinase, active site	PROSITE	PS00109	PROTEIN_KINASE_TYR	coord: 620..632
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 506..532
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 500..759 score: 37.828
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 494..774