Nalp (Nacht leucine rich repeat and pyrin domain containing)

Overview
NameNalp (Nacht leucine rich repeat and pyrin domain containing)
Smed IDSMED30003047
Length (bp)1719
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Nalp (Nacht leucine rich repeat and pyrin domain containing) (SMED30003047) t-SNE clustered cells

Violin plots show distribution of expression levels for Nalp (Nacht leucine rich repeat and pyrin domain containing) (SMED30003047) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Nalp (Nacht leucine rich repeat and pyrin domain containing) (SMED30003047) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Nalp (Nacht leucine rich repeat and pyrin domain containing) (SMED30003047) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30003047

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30003047h1SMcG0003190 SmedASXL_014559SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30003047h1SMcG0003190 dd_Smed_v4_16437_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30003047h1SMcG0003190 dd_Smed_v4_16437_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30003047h1SMcG0003190 dd_Smed_v6_16437_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
reproductive organSMED30003047h1SMcG0003190 Contig42780newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30003047h1SMcG0003190 Contig42780uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Zebrafish
Match: si:ch211-202c21.7 (si:ch211-202c21.7 [Source:ZFIN;Acc:ZDB-GENE-081031-16])

HSP 1 Score: 67.0106 bits (162), Expect = 3.254e-12
Identity = 41/129 (31.78%), Postives = 70/129 (54.26%), Query Frame = 1 
Query:  508 PLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIAR---SIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPI 885
            PLL A+R++RY H+QE  +W +     D+  L  ++ R   ++Y F  +EL++C L    +++L  ++ A   L  + LD+   G EG + + +G  G+  +  LS+CYC L   SG  L  L+   P+
Sbjct:   77 PLLMAIRDERYTHVQEFHIWSLSFKQTDVVELCFLMERRGTTVYPFRLLELLDCRLSEWSMKRLGKAL-ATSYLTTLCLDYTLVGQEGLKGLLSGGLGSGQICSLSLCYCGLGSWSGTLLASLLTNGPV 204
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Xenopus
Match: nt5e (5'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:XB-GENE-984211])

HSP 1 Score: 50.447 bits (119), Expect = 6.610e-6
Identity = 29/79 (36.71%), Postives = 46/79 (58.23%), Query Frame = 1 
Query:  709 CRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLD--GNELKAEGVILL 939
             +TL+ +NL  N  G+EG R +  GL GNR +L+L +    L+    + + E VA++P R + LD   NE+K  G++ L
Sbjct:  325 TQTLETLNLGHNAIGNEGVRHLKNGLIGNRSVLRLGLASAKLTCEGAVAVAEFVAESP-RLLRLDLRENEIKTGGLMAL 402
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Xenopus
Match: nt5e (5'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:XB-GENE-984211])

HSP 1 Score: 50.447 bits (119), Expect = 8.219e-6
Identity = 27/77 (35.06%), Postives = 45/77 (58.44%), Query Frame = 1 
Query:  712 RTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTP-IREIYLDGNELKAEGVILL 939
            +TL+ +NL  N  G+EG R +  GL GNR +L+L +    L+    + + E VA++P +  + L  NE+K  G++ L
Sbjct:  326 QTLETLNLGHNAIGNEGVRHLKNGLIGNRSVLRLGLASAKLTCEGAVAVAEFVAESPRLLRLDLRENEIKTGGLMAL 402
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Xenopus
Match: nt5e (5'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:XB-GENE-984211])

HSP 1 Score: 50.447 bits (119), Expect = 8.344e-6
Identity = 29/79 (36.71%), Postives = 46/79 (58.23%), Query Frame = 1 
Query:  709 CRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLD--GNELKAEGVILL 939
             +TL+ +NL  N  G+EG R +  GL GNR +L+L +    L+    + + E VA++P R + LD   NE+K  G++ L
Sbjct:  325 TQTLETLNLGHNAIGNEGVRHLKNGLIGNRSVLRLGLASAKLTCEGAVAVAEFVAESP-RLLRLDLRENEIKTGGLMAL 402
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Xenopus
Match: nt5e (5'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:XB-GENE-984211])

HSP 1 Score: 50.447 bits (119), Expect = 8.698e-6
Identity = 29/78 (37.18%), Postives = 46/78 (58.97%), Query Frame = 1 
Query:  712 RTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLD--GNELKAEGVILL 939
            +TL+ +NL  N  G+EG R +  GL GNR +L+L +    L+    + + E VA++P R + LD   NE+K  G++ L
Sbjct:  408 QTLETLNLGHNAIGNEGVRHLKNGLIGNRSVLRLGLASAKLTCEGAVAVAEFVAESP-RLLRLDLRENEIKTGGLMAL 484
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Xenopus
Match: nt5e (5'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:XB-GENE-984211])

HSP 1 Score: 50.0618 bits (118), Expect = 8.764e-6
Identity = 27/77 (35.06%), Postives = 45/77 (58.44%), Query Frame = 1 
Query:  712 RTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTP-IREIYLDGNELKAEGVILL 939
            +TL+ +NL  N  G+EG R +  GL GNR +L+L +    L+    + + E VA++P +  + L  NE+K  G++ L
Sbjct:  327 QTLETLNLGHNAIGNEGVRHLKNGLIGNRSVLRLGLASAKLTCEGAVAVAEFVAESPRLLRLDLRENEIKTGGLMAL 403
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Mouse
Match: Gm28729 (predicted gene 28729 [Source:MGI Symbol;Acc:MGI:5579435])

HSP 1 Score: 79.7221 bits (195), Expect = 1.607e-15
Identity = 61/252 (24.21%), Postives = 113/252 (44.84%), Query Frame = 1 
Query:  211 GAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMI---ARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQ 957
            GAA      L++ +K Y   C     + C  + R L++  +  ++L +F++      +        LP                           V + PLL  +R++ Y   +E+ +W + +   +I  L+  +     +      +E+++C +D   L +L  ++    +L  + LD+ +FG+E   +I +GL  NR L  LSM YC L   SG  LG +++ + I E+ LDGN L++ G + LL  + +
Sbjct:   13 GAAPSVVPALQKFLKTYQKHCVQSRTSVCPAIHRDLKSSIDREQILGKFMLV-----RAGNSSASTLP---------------------------VSLEPLLMTIRDEGYTLGKEICIWGLQLTNPEIARLALFLEQKGHTTCPVTTLEIIDCKMDLWSLGRLGKALQFS-SLHFLVLDYCKFGNEELESIFSGLESNRRLQGLSMRYCGLGPQSGPRLGSVISHSGICELRLDGNHLQSSGALALLRPIAE 231

HSP 2 Score: 53.9138 bits (128), Expect = 3.333e-7
Identity = 32/92 (34.78%), Postives = 49/92 (53.26%), Query Frame = 1 
Query: 1225 VGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLI 1500
             GP I  + +ADN ID  GR G    +   +   ++I  +  L ++DL  N +G+  +  +LE L +RK  KLP + + V  RI+ DTF  I
Sbjct:  300 AGPWIVTLCLADNSIDGTGREGEPL-LEFTRTVTSLIKYSTHLREMDLGNNVLGETAAVDILEALRVRKTGKLPPLKVTVTPRISSDTFRSI 390
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. TrEMBL
Match: A0A1S8X8H4 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=X801_01352 PE=4 SV=1)

HSP 1 Score: 335.495 bits (859), Expect = 8.131e-106
Identity = 191/425 (44.94%), Postives = 283/425 (66.59%), Query Frame = 1 
Query:  238 LKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNID--EFEPTSEI--TSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLI 1500
            LKEL+++Y++R + Y       +R+Q +   ++ +++ RF++DP+DRR VEYW+D+ L       D     +++ K K  KE + LVK+LPL++A+R +RY HIQEL VW+  +  DD  +++ ++ R  Y   R+EL++CFLDSK +  ++ ++   +TL+E+ LDFNE G++GCR +CTGL+  R+L  LS+ YC L+K  GL+LG LV +T IRE+ LDGN L+AEGVI LL+QL + AE E  ER E++  + +       A  TRP  ++D   FE  +    T + ++         A  +  K   + + K+ K+  K     PPP GPQI  +++AD GI+ MGRGGNFAP+RCMQL K+II++++DL++IDLFGN IGDLG+RQ+LEG++ RK  KLPQIGIR+GHRINQDTFD+I
Sbjct:   23 LKELMRDYEIRAEKYETTVANSIRKQFKKALDDDRLVTRFVVDPQDRRVVEYWDDEKLVKALQG-DADEGRRRRAKIKHVKEDKPLVKILPLIDAIRARRYTHIQELLVWDCHVENDDALSIAGLLTRGCYPVSRLELIDCFLDSKSVGNIVTAVAVSKTLKELALDFNELGEKGCRILCTGLSRGRFLTHLSLSYCGLTKQCGLWLGNLVCETAIRELVLDGNPLEAEGVIALLSQLAEAAENEGFERAEEEKRRLKAIEDARRA--TRPILDMDLSGFEQNANAGETDKPSSPAPSLGKPIAKPESGKAEIKSRKKRGKRGRKGGKLEPPPAGPQISVLKLADTGINHMGRGGNFAPVRCMQLLKSIISHSRDLQEIDLFGNAIGDLGARQILEGILTRKEAKLPQIGIRMGHRINQDTFDII 444
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. TrEMBL
Match: A0A504Y3U7 (Nalp (Nacht leucine rich repeat and pyrin domain containing) OS=Fasciola gigantica OX=46835 GN=FGIG_06655 PE=4 SV=1)

HSP 1 Score: 329.331 bits (843), Expect = 3.952e-103
Identity = 201/451 (44.57%), Postives = 293/451 (64.97%), Query Frame = 1 
Query:  226 ASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHR---------------FLIDPKDRRKVEYWEDDDLPGQFAPIDILSELX-XXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNID---------EFEP-TSEITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLI 1500
            A + ++EL+K+Y++R + Y       +R+QL+  Q++ ++L R               FL+DP+DRR VEYW+DD +    +  D+   L+ KK K K +KE + LVKVLPL+E+LR +RY  +QE FVW+  +  DD  AL+ ++AR  Y   RIELV+CFLD++ +  L  +I   RTL+++ LDFN+ G+ GCR +C GL+ +R+L+ LS+ +C L+K  GL++G LV +T IRE+ LDGN L+AEGVI LL+QL + AE E  ER E+   K+  +    A    RP  ++D           EP T+E ++ + +      P K  +     +K++  KK K+  K     PPP GPQI  +R+AD GI+ MGRGGNFAP+RCMQL K+II+++KDL++IDLF N++GDLG+RQ+LEG++ RK  KLPQIG+R+GHRINQDTFD+I
Sbjct:   18 AIRAMRELLKDYEIRAERYETTVAGSIRKQLKKAQDDDRLLTRVSLLIATFYEKILLQFLVDPQDRRLVEYWDDDKMIKALSG-DVDEGLRRKKAKHKQQKEDKPLVKVLPLIESLRARRYTQLQEFFVWDCHVENDDSIALAGILARGCYPLTRIELVDCFLDARSVGTLAAAIAYSRTLRDLCLDFNDLGERGCRVLCGGLSKSRYLVHLSLSFCGLTKQCGLWIGNLVVETAIRELVLDGNPLEAEGVIALLSQLSEAAESEGFERAEEIKRKQLAQEE--AKRGARPAIDLDAPEHNELPASSEPNTTEGSTASPSPQAGKTPDKENESSSPSSKKRGKKKGKRGKKGAKNEPPPSGPQISILRLADTGINHMGRGGNFAPVRCMQLLKSIISHSKDLQEIDLFANEVGDLGARQILEGILARKDAKLPQIGVRMGHRINQDTFDVI 465
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. TrEMBL
Match: A0A075A7P4 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_02156 PE=4 SV=1)

HSP 1 Score: 327.02 bits (837), Expect = 7.796e-103
Identity = 186/421 (44.18%), Postives = 279/421 (66.27%), Query Frame = 1 
Query:  250 IKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNID--EFEPTSEI--TSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLI 1500
            +++Y++R + Y       +R+Q +   ++ +++ RF++DP+DRR VEYW+D+ L       D     +++ K K  KE + LVK+LPL++A+R +RY HIQEL VW+  +  DD  +++ ++ R  Y   R+EL++CFLDSK +  ++ ++   +TL+E+ LDFNE G++GCR +CTGL+  ++L  LS+ YC L+K  GL+LG LV +T IRE+ LDGN L+AEGVI LL+QL + AE E  ER E++  + +       A  TRP  ++D   FE  +    T + ++         A  +  K   + + K+ K+  K     PPP GPQI  +++AD GI+ MGRGGNFAP+RCMQL K+II++++DL++IDLFGN IGDLG+RQ+LEG++ RK  KLPQIGIR+GHRINQDTFD+I
Sbjct:    1 MRDYEIRAEKYETTVANSIRKQFKKALDDDRLVTRFVVDPQDRRVVEYWDDEKLVKALQG-DADEGRRRRAKIKHVKEDKPLVKILPLIDAIRARRYTHIQELLVWDCHVENDDALSIAGLLTRGCYPVSRLELIDCFLDSKSVGNIVTAVAVSKTLKELALDFNELGEKGCRILCTGLSRGKFLTHLSLSYCGLTKQCGLWLGNLVCETAIRELVLDGNPLEAEGVIALLSQLAEAAENEGFERAEEEKRRLKAIEDARRA--TRPILDMDLSGFEQNANAGETDKPSSPAPSLGKPIAKPESGKAEIKSRKKRGKRGRKGGKLEPPPAGPQISVLKLADTGINHMGRGGNFAPVRCMQLLKSIISHSRDLQEIDLFGNAIGDLGARQILEGILTRKEAKLPQIGIRMGHRINQDTFDII 418
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. TrEMBL
Match: A0A4E0RK73 (Nalp (Nacht leucine rich repeat and pyrin domain containing) OS=Fasciola hepatica OX=6192 GN=D915_001003 PE=4 SV=1)

HSP 1 Score: 328.561 bits (841), Expect = 8.654e-103
Identity = 200/451 (44.35%), Postives = 287/451 (63.64%), Query Frame = 1 
Query:  226 ASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHR---------------FLIDPKDRRKVEYWEDDDLPGQFAPIDILSELX-XXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNID-----EFEPTSEI-TSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----VGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLI 1500
            A + ++EL+K+Y++R + Y       +R+QL+  Q++ ++L R               FL+DP+DRR VEYW+DD +    +  D+   L+ KK K K +KE + LVKVLPL+E+LR +RY  +QE FVW+  +  DD  AL+ ++AR  Y   RIELV+CFLD++ +  L  +I   RTL+++ LDFN+ G+ GCR +C GL+ +R+L+ LS+ +C L+K  GL++G LV +T IRE+ LDGN L+AEGVI LL+QL + AE E  ER E+   K+  +    A    RP  ++D     E   +SE  T+E +T        K   K  +       K+ KKK K             GPQI  +R+AD GI+ MGRGGNFAP+RCMQL K+II+++KDL++IDLF N++GDLG+RQ+LEG++ RK  KLPQIG+R+GHRINQDTFD+I
Sbjct:   18 AIRAMRELLKDYEIRAERYETTVAGSIRKQLKKAQDDDRLLTRVSLFIATFYEKILLQFLVDPQDRRLVEYWDDDKMIKALSG-DVDEGLRRKKAKHKQQKEDKPLVKVLPLIESLRARRYTQLQEFFVWDCHVENDDSIALAGILARGCYPLTRIELVDCFLDARSVGTLAAAIAYSRTLRDLCLDFNDLGERGCRVLCGGLSKSRYLVHLSLSFCGLTKQCGLWIGNLVVETAIRELVLDGNPLEAEGVIALLSQLSEAAESEGFERAEEIKRKQLAQEE--AKRGARPAIDLDAPEHNELPASSEPNTTEGSTASPPPQAGKTPDKENESRSPSSKKRSKKKGKRGKKGAKNEPPPSGPQISILRLADTGINHMGRGGNFAPVRCMQLLKSIISHSKDLQEIDLFANEVGDLGARQILEGILARKDAKLPQIGVRMGHRINQDTFDVI 465
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. TrEMBL
Match: A0A0R3W158 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS3451 PE=4 SV=2)

HSP 1 Score: 304.294 bits (778), Expect = 1.970e-93
Identity = 182/446 (40.81%), Postives = 269/446 (60.31%), Query Frame = 1 
Query:  232 KLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQN-LVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNIDEFEPTSE------------ITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKT----------IIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLI 1500
            KLLK + K+Y+  C+ +  + C  ++  LR    E  ++  F++DPKDRR VEYW+D      F      ++LKKK K K   + +  L ++LPL++ALRN RY+ I+EL+VW V + Y D+  L +M+A+  Y+   IEL++CF++ K ++   P++N  +TL+++ LDFNEFGD GC  +C GL   RWL++LS+C+C L+K SG++LG L+A+T IRE++LDGN L+AEG   LL QL +      + +  ++L  E+  A VA A   R R ++D     SE            + SEN  V+T                       ++K+K   A  PP GPQI  + +A+N I+ +GRGG+FAP RCMQL KT          IIA +KDL+++D+FGNDIG +  R +LEG++ RK N LP+IG+RV H INQDT+D+I
Sbjct:   47 KLLKSVYKDYERICNEFNCSMCPKIKETLRRGISEEVIIRTFVMDPKDRRNVEYWDDKKFVEWFQSGHEETQLKKKGKTKKGLKGEKPLARLLPLIDALRNNRYLQIKELYVWSVYLEYSDMLCLGSMVAKGNYELSYIELIDCFINQKAIDAFAPNVNYTKTLRDLILDFNEFGDSGCYALCEGLKSCRWLIRLSVCFCGLNKQSGIWLGNLIAETSIRELFLDGNNLEAEGATALLTQLAEA--AYLEGKERERLKAEKMAAEVAQAQAARKRIDLDAPLAESEKHANENANTVNNLNSENVPVNT--------------------YTQERKNKRKGAKMPPCGPQITHLHMAENSINSIGRGGSFAPARCMQLLKTQVHLKLSDLHIIAYSKDLQEVDIFGNDIGQVAGRIVLEGILARKDNNLPRIGVRVTHLINQDTYDMI 470
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Nematostella
Match: EDO46032 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR11])

HSP 1 Score: 137.887 bits (346), Expect = 1.825e-35
Identity = 78/238 (32.77%), Postives = 129/238 (54.20%), Query Frame = 1 
Query:  229 SKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLL 942
            ++LLK +   Y+ +C    +     +++ L  + E++ +L +F++ P          +D+LP                           VKV PLL A+R  RYI+++EL++W++ M ++D+ +L+  + + +Y    +EL+ C +DS  +E+   S      L  + LDFNEFGD GC  +C GL  N  LL+LS+ YC L   SG+ LG+ V+ T IR++YLDGN+L  EGV+ L+
Sbjct:   29 AELLKAVRVNYESKCKEMKSYVHPEVKKLLNQYGEDNTLLAKFILTPG--------PEDELP---------------------------VKVQPLLAAMRVMRYIYLKELYIWDIPMKHEDVASLALFLEQPMYPVQYLELMECSIDSYAIERFGRSF-MFNNLTALVLDFNEFGDAGCAGLCKGLKANGTLLKLSLNYCGLGPHSGVILGDTVSNTAIRDLYLDGNKLGCEGVMELM 230

HSP 2 Score: 80.4925 bits (197), Expect = 3.539e-16
Identity = 36/85 (42.35%), Postives = 55/85 (64.71%), Query Frame = 1 
Query: 1237 IEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTF 1491
            I+K+ + DNG+D  G      P+ CM++F+ +I +++ L++IDL  N IGDLG R+++EGL  RK   L  I + V HR+N  TF
Sbjct:  327 IQKVHLLDNGVDSYGSASTLGPIMCMKMFRKLITHSEGLQEIDLDDNLIGDLGGREIMEGLTDRKEAGLNSIKMNVTHRMNPTTF 411
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Nematostella
Match: EDO39348 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAC5])

HSP 1 Score: 48.1358 bits (113), Expect = 4.336e-6
Identity = 23/73 (31.51%), Postives = 41/73 (56.16%), Query Frame = 1 
Query:  715 TLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTP-IREIYLDGNELKAEGV 930
            +L+E+ + +N FGDEG + +C GL  NR L  L +C+ ++ +    Y+ E +     + E+ LD N +   G+
Sbjct:  144 SLRELYIGWNHFGDEGAKHLCAGLQENRSLEILDICWNEIGRDGAGYIAEFIENNGRLVELNLDNNHITDHGL 216
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Planmine SMEST
Match: SMESG000047177.1 (SMESG000047177.1)

HSP 1 Score: 717.613 bits (1851), Expect = 0.000e+0
Identity = 432/433 (99.77%), Postives = 433/433 (100.00%), Query Frame = 1 
Query:  205 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNIDEFEPTSEITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 1503
            QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELV+CFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQAPPAKAGKKGKKKNKRKKSKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT
Sbjct:   21 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVDCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQAPPAKAGKKGKKKNKRKKSKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 453
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Planmine SMEST
Match: SMESG000045615.1 (SMESG000045615.1)

HSP 1 Score: 717.613 bits (1851), Expect = 0.000e+0
Identity = 432/433 (99.77%), Postives = 433/433 (100.00%), Query Frame = 1 
Query:  205 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNIDEFEPTSEITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 1503
            QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELV+CFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQAPPAKAGKKGKKKNKRKKSKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT
Sbjct:   21 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVDCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQAPPAKAGKKGKKKNKRKKSKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 453
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Planmine SMEST
Match: SMESG000047177.1 (SMESG000047177.1)

HSP 1 Score: 713.375 bits (1840), Expect = 0.000e+0
Identity = 415/433 (95.84%), Postives = 416/433 (96.07%), Query Frame = 1 
Query:  205 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNIDEFEPTSEITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 1503
            QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELV+CFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQ                KK KKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT
Sbjct:   21 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVDCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQ---------APPAKAGKKGKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 444
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Planmine SMEST
Match: SMESG000045615.1 (SMESG000045615.1)

HSP 1 Score: 713.375 bits (1840), Expect = 0.000e+0
Identity = 415/433 (95.84%), Postives = 416/433 (96.07%), Query Frame = 1 
Query:  205 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNIDEFEPTSEITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 1503
            QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELV+CFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQ                KK KKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT
Sbjct:   21 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVDCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTSEITSENATVDTQ---------APPAKAGKKGKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 444
[Close]
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Planmine SMEST
Match: SMESG000047177.1 (SMESG000047177.1)

HSP 1 Score: 682.559 bits (1760), Expect = 0.000e+0
Identity = 403/433 (93.07%), Postives = 406/433 (93.76%), Query Frame = 1 
Query:  205 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELXXXXXXXXXXEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGXXXXXXXXXXXXXXXXXXXXXVAAASDTRPRYNIDEFEPTSEITSENATVDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 1503
            QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELV+CFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPT     +   V  +           K  K    KKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT
Sbjct:   21 QTGAAVDASKLLKELIKEYDVRCDVYCAAPCLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILSELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDICALSAMIARSIYQFVRIELVDCFLDSKCLEKLIPSINACRTLQEINLDFNEFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREIYLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDTRPRYNIDEFEPTLRRLRQEKKVKRK----------IKGKKVIFCKKPKKKSKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANAKDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFDLIT 443
The following BLAST results are available for this feature:
BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
si:ch211-202c21.73.254e-1231.78si:ch211-202c21.7 [Source:ZFIN;Acc:ZDB-GENE-081031... [more]
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nt5e6.610e-636.715'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:X... [more]
nt5e8.219e-635.065'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:X... [more]
nt5e8.344e-636.715'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:X... [more]
nt5e8.698e-637.185'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:X... [more]
nt5e8.764e-635.065'-nucleotidase, ecto (CD73) [Source:Xenbase;Acc:X... [more]
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Gm287291.607e-1524.21predicted gene 28729 [Source:MGI Symbol;Acc:MGI:55... [more]
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S8X8H48.131e-10644.94Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A504Y3U73.952e-10344.57Nalp (Nacht leucine rich repeat and pyrin domain c... [more]
A0A075A7P47.796e-10344.18Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A4E0RK738.654e-10344.35Nalp (Nacht leucine rich repeat and pyrin domain c... [more]
A0A0R3W1581.970e-9340.81Uncharacterized protein OS=Taenia asiatica OX=6051... [more]
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO460321.825e-3532.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO393484.336e-631.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nalp (Nacht leucine rich repeat and pyrin domain containing) vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000047177.10.000e+099.77SMESG000047177.1[more]
SMESG000045615.10.000e+099.77SMESG000045615.1[more]
SMESG000047177.10.000e+095.84SMESG000047177.1[more]
SMESG000045615.10.000e+095.84SMESG000045615.1[more]
SMESG000047177.10.000e+093.07SMESG000047177.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30003047 ID=SMED30003047|Name=Nalp (Nacht leucine rich repeat and pyrin domain containing)|organism=Schmidtea mediterranea sexual|type=transcript|length=1719bp
TTTCTATAACAACATAAAGCGGTTTTATAAAATTATTTTTAATTATAATT
TAATTTATGACAATGAATCACGTTTGAAAGAGATCTAAAGTTTCTTTGTG
TTTGATACTTTTGTAAATAATAACATAAGCTTAACTTCGATCAAATGCCA
CCAAAACCAGCAAAGACCAAGAAGGATAAAAAAAATGATAAAAAGAAAAA
GAAGCAGACAGGAGCAGCAGTTGATGCTTCTAAATTGCTTAAAGAATTAA
TTAAAGAATATGATGTAAGATGTGATGTTTACTGTGCTGCTCCTTGTTTG
CCTCTGCGACGTCAGTTGAGAACGTTTCAAGAAGAATCAAAAGTGCTTCA
TAGATTTTTAATTGACCCTAAAGATCGTCGAAAAGTAGAATACTGGGAAG
ATGATGATTTACCAGGGCAATTTGCTCCAATTGATATACTATCAGAATTA
AAAAAGAAACCCAAGAAAAAAGGAAAAAAAGAGCATCAAAATCTAGTCAA
AGTTTTACCGCTTTTAGAGGCATTGCGAAATAAAAGATATATTCATATTC
AAGAATTATTTGTCTGGGAAGTGATGATGGCATATGATGATATATGTGCC
CTGTCTGCAATGATAGCAAGAAGCATTTATCAATTTGTCAGAATAGAACT
AGTCAATTGCTTTCTTGATTCCAAGTGTTTGGAAAAACTTATTCCATCCA
TAAATGCTTGTAGAACTCTTCAAGAAATCAATTTAGATTTCAACGAGTTT
GGAGATGAAGGCTGTAGGACTATATGTACTGGTTTAACTGGTAACCGTTG
GCTTCTACAGTTGAGTATGTGTTACTGTGACCTTTCTAAGACTAGTGGAC
TTTATCTTGGTGAATTGGTGGCCAAAACCCCTATCAGAGAAATATATTTA
GATGGAAATGAATTGAAAGCTGAAGGAGTCATATTATTATTGAATCAATT
ATGCCAAGGAGCTGAACAAGAAGCTCAAGAAAGACTTGAACAAAAATTAT
TGAAAGAAGAGCAGGAAGCAGCCGTTGCTGCAGCTTCGGATACAAGGCCT
AGATATAATATTGATGAATTCGAGCCCACGTCGGAAATTACATCTGAAAA
TGCAACAGTAGATACTCAGGCTCCGCCGGCTAAGGCAGGCAAAAAAGGTA
AAAAGAAAAATAAAAGGAAAAAAAGTAAAAAGCCGAAAAAAAAATCCAAA
AGTTTCATGGCACCCCCTCCTCCCGTTGGGCCACAGATTGAAAAAATAAG
AGTAGCTGATAACGGAATTGATCAAATGGGAAGAGGCGGAAATTTCGCTC
CTATGCGTTGTATGCAATTATTTAAAACAATCATTGCAAATGCCAAAGAT
CTTGAAGATATTGATCTATTTGGAAACGATATTGGAGATCTAGGTTCCAG
GCAATTGCTCGAAGGTTTAATATTAAGAAAAGCCAATAAACTACCTCAGA
TTGGAATTAGAGTTGGACATAGAATCAACCAAGATACTTTTGACCTAATA
ACAAAGTTGGCTCCTGGTGCAAAAAAGAAAAAGCGTGGAAAAGCCAAAAA
ATAACTTGAAAGTTTTGTTCGAAGAAATCTCATAATTCTTCTTAAGTCTG
TATTATGAAGGCGGTTAATGTGATTGAGTAGGAATTAGACGTACTTATGT
TATAAGTGACGTAATATTCTGTTTTATGCGCATTCATGAGATCATCAATA
AATGATATTTTAATGCGAA
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protein sequence of SMED30003047-orf-1

>SMED30003047-orf-1 ID=SMED30003047-orf-1|Name=SMED30003047-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=470bp
MPPKPAKTKKDKKNDKKKKKQTGAAVDASKLLKELIKEYDVRCDVYCAAP
CLPLRRQLRTFQEESKVLHRFLIDPKDRRKVEYWEDDDLPGQFAPIDILS
ELKKKPKKKGKKEHQNLVKVLPLLEALRNKRYIHIQELFVWEVMMAYDDI
CALSAMIARSIYQFVRIELVNCFLDSKCLEKLIPSINACRTLQEINLDFN
EFGDEGCRTICTGLTGNRWLLQLSMCYCDLSKTSGLYLGELVAKTPIREI
YLDGNELKAEGVILLLNQLCQGAEQEAQERLEQKLLKEEQEAAVAAASDT
RPRYNIDEFEPTSEITSENATVDTQAPPAKAGKKGKKKNKRKKSKKPKKK
SKSFMAPPPPVGPQIEKIRVADNGIDQMGRGGNFAPMRCMQLFKTIIANA
KDLEDIDLFGNDIGDLGSRQLLEGLILRKANKLPQIGIRVGHRINQDTFD
LITKLAPGAKKKKRGKAKK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000418head
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR001611Leu-rich_rpt
IPR032675LRR_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 278..298
NoneNo IPR availableSMARTSM00368LRR_RI_2coord: 244..271
e-value: 10.0
score: 10.1
coord: 400..427
e-value: 2.3
score: 14.6
coord: 189..216
e-value: 0.44
score: 19.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..24
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 310..324
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 293..361
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 331..352
NoneNo IPR availablePANTHERPTHR24107FAMILY NOT NAMEDcoord: 7..468
NoneNo IPR availablePANTHERPTHR24107:SF18coord: 7..468
NoneNo IPR availableSUPERFAMILYSSF52047RNI-likecoord: 125..426
IPR001611Leucine-rich repeatPFAMPF13516LRR_6coord: 189..211
e-value: 0.0037
score: 17.2
IPR032675Leucine-rich repeat domain superfamilyGENE3DG3DSA:3.80.10.10coord: 116..308
e-value: 1.8E-19
score: 71.7