transcription factor 7-like 2 isoform X1

Overview
Nametranscription factor 7-like 2 isoform X1
Smed IDSMED30002969
Length (bp)1697
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of transcription factor 7-like 2 isoform X1 (SMED30002969) t-SNE clustered cells

Violin plots show distribution of expression levels for transcription factor 7-like 2 isoform X1 (SMED30002969) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of transcription factor 7-like 2 isoform X1 (SMED30002969) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for transcription factor 7-like 2 isoform X1 (SMED30002969) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30002969

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30002969h1SMcG0014633 SmedASXL_014881SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
X2 cellSMED30002969h1SMcG0014633 SmedASXL_014881SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30002969h1SMcG0014633 dd_Smed_v4_13056_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30002969h1SMcG0014633 dd_Smed_v4_13056_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30002969h1SMcG0014633 dd_Smed_v4_13056_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30002969h1SMcG0014633 dd_Smed_v6_13056_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
cephalic gangliaSMED30002969h1SMcG0014633 dd_Smed_v6_13056_0_1dd_Smed_v6PMID:29291981
Brown et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
stem cellSMED30002969h1SMcG0014633 dd_Smed_v6_13056_0_1dd_Smed_v6PMID:29291981
Brown et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
central nervous systemSMED30002969h1SMcG0014633 KJ934816smed_ncbi_20240424PMID:25254346
Scimone et al., 2014		whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30002969h1SMcG0014633 KY196226smed_ncbi_20240424PMID:28976975
Su et al., 2017		whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30002969h1SMcG0014633 dd_Smed_v4_13056_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 158.303 bits (399), Expect = 1.639e-44
Identity = 71/91 (78.02%), Postives = 82/91 (90.11%), Query Frame = 3 
Query:  585 LKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            LK    ++  ++ KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:   41 LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 131
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 155.606 bits (392), Expect = 2.414e-44
Identity = 71/91 (78.02%), Postives = 82/91 (90.11%), Query Frame = 3 
Query:  585 LKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            LK    ++  ++ KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:   30 LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 120
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Human
Match: LEF1 (lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551])

HSP 1 Score: 160.229 bits (404), Expect = 3.770e-44
Identity = 79/135 (58.52%), Postives = 93/135 (68.89%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  151 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 276
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Human
Match: LEF1 (lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551])

HSP 1 Score: 160.614 bits (405), Expect = 1.851e-43
Identity = 79/135 (58.52%), Postives = 93/135 (68.89%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  219 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 344
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Human
Match: TCF7 (transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639])

HSP 1 Score: 157.147 bits (396), Expect = 2.157e-43
Identity = 71/91 (78.02%), Postives = 82/91 (90.11%), Query Frame = 3 
Query:  585 LKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            LK    ++  ++ KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  137 LKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 227
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Celegans
Match: pop-1 (pep chromosome:WBcel235:I:2823254:2830311:-1 gene:WBGene00004077.1 transcript:W10C8.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:pop-1)

HSP 1 Score: 105.531 bits (262), Expect = 4.254e-24
Identity = 47/82 (57.32%), Postives = 62/82 (75.61%), Query Frame = 3 
Query:  624 KKPHIKKPLNAFMLFMKEMRAKVVAEC--TLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYAC 863
            K  H+KKPLNAFM FMKE R  ++ E     K+SA +N+ LG+RWH L++E+QAKY+EMA+K+KE H + YP WSAR+NYA 
Sbjct:  188 KDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAV 269
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Celegans
Match: gei-3 (GEX Interacting protein [Source:UniProtKB/TrEMBL;Acc:Q0G834])

HSP 1 Score: 65.855 bits (159), Expect = 5.911e-11
Identity = 25/71 (35.21%), Postives = 48/71 (67.61%), Query Frame = 3 
Query:  627 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            +PH+++P+NAFM+F K  R  V  +   K++  +++ILG  W++L  + +A+Y+++A + KE H + +P W
Sbjct:  840 EPHVRRPMNAFMIFSKRHRPLVHQQYPNKDNRTVSKILGEWWYSLAADQKAEYHKLATQVKEAHFKAHPDW 910
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Celegans
Match: gei-3 (GEX Interacting protein [Source:UniProtKB/TrEMBL;Acc:Q0G834])

HSP 1 Score: 65.0846 bits (157), Expect = 8.927e-11
Identity = 25/71 (35.21%), Postives = 48/71 (67.61%), Query Frame = 3 
Query:  627 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            +PH+++P+NAFM+F K  R  V  +   K++  +++ILG  W++L  + +A+Y+++A + KE H + +P W
Sbjct:   75 EPHVRRPMNAFMIFSKRHRPLVHQQYPNKDNRTVSKILGEWWYSLAADQKAEYHKLATQVKEAHFKAHPDW 145
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Celegans
Match: egl-13 (Transcription factor egl-13 [Source:UniProtKB/Swiss-Prot;Acc:Q23045])

HSP 1 Score: 56.225 bits (134), Expect = 2.063e-8
Identity = 23/72 (31.94%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  633 HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSAR 848
            HIK+P+NAFM++ ++ R K++       ++ I++ILG RW  ++  ++  YYE   +  +LH + +P +  R
Sbjct:  171 HIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYR 242
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Celegans
Match: egl-13 (Transcription factor egl-13 [Source:UniProtKB/Swiss-Prot;Acc:Q23045])

HSP 1 Score: 56.225 bits (134), Expect = 2.063e-8
Identity = 23/72 (31.94%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  633 HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSAR 848
            HIK+P+NAFM++ ++ R K++       ++ I++ILG RW  ++  ++  YYE   +  +LH + +P +  R
Sbjct:  171 HIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYR 242
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0334301)

HSP 1 Score: 157.532 bits (397), Expect = 1.444e-40
Identity = 71/89 (79.78%), Postives = 81/89 (91.01%), Query Frame = 3 
Query:  600 TNENAEKT---KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +NE+ E T   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH L+RE+Q+KYYE AR+E++LH +LYPGWSARDNY
Sbjct:  258 SNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNY 346
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0112657)

HSP 1 Score: 158.688 bits (400), Expect = 1.469e-40
Identity = 71/89 (79.78%), Postives = 81/89 (91.01%), Query Frame = 3 
Query:  600 TNENAEKT---KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +NE+ E T   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH L+RE+Q+KYYE AR+E++LH +LYPGWSARDNY
Sbjct:  699 SNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNY 787
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0089161)

HSP 1 Score: 157.532 bits (397), Expect = 1.669e-40
Identity = 71/89 (79.78%), Postives = 81/89 (91.01%), Query Frame = 3 
Query:  600 TNENAEKT---KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +NE+ E T   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH L+RE+Q+KYYE AR+E++LH +LYPGWSARDNY
Sbjct:  258 SNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNY 346
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0089159)

HSP 1 Score: 157.532 bits (397), Expect = 1.669e-40
Identity = 71/89 (79.78%), Postives = 81/89 (91.01%), Query Frame = 3 
Query:  600 TNENAEKT---KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +NE+ E T   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH L+RE+Q+KYYE AR+E++LH +LYPGWSARDNY
Sbjct:  258 SNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNY 346
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Fly
Match: pan (gene:FBgn0085432 transcript:FBtr0089162)

HSP 1 Score: 157.532 bits (397), Expect = 1.669e-40
Identity = 71/89 (79.78%), Postives = 81/89 (91.01%), Query Frame = 3 
Query:  600 TNENAEKT---KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +NE+ E T   KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH L+RE+Q+KYYE AR+E++LH +LYPGWSARDNY
Sbjct:  258 SNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNY 346
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Zebrafish
Match: lef1 (lymphoid enhancer-binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-990714-26])

HSP 1 Score: 155.221 bits (391), Expect = 1.630e-44
Identity = 71/93 (76.34%), Postives = 81/93 (87.10%), Query Frame = 3 
Query:  579 MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:    8 MHMKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 100
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Zebrafish
Match: lef1 (lymphoid enhancer-binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-990714-26])

HSP 1 Score: 161.77 bits (408), Expect = 2.915e-44
Identity = 81/135 (60.00%), Postives = 94/135 (69.63%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            VPG P      G + TGIP        +  N     +     M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  216 VPGPP------GPHATGIPHP------AIVNPQVKQEHDTDLMHMKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 338
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Zebrafish
Match: lef1 (lymphoid enhancer-binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-990714-26])

HSP 1 Score: 161.77 bits (408), Expect = 3.122e-44
Identity = 81/136 (59.56%), Postives = 94/136 (69.12%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            VPG P      G + TGIP        +  N     +     M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  215 VPGPP------GPHATGIPHP------AIVNPQVKQEHDTDLMHMKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 338
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Zebrafish
Match: tcf7l1a (transcription factor 7 like 1a [Source:NCBI gene;Acc:30523])

HSP 1 Score: 163.31 bits (412), Expect = 3.462e-44
Identity = 71/81 (87.65%), Postives = 79/81 (97.53%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  193 EEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY 273
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Zebrafish
Match: tcf7l1b (transcription factor 7 like 1b [Source:NCBI gene;Acc:30556])

HSP 1 Score: 162.155 bits (409), Expect = 9.306e-44
Identity = 92/168 (54.76%), Postives = 107/168 (63.69%), Query Frame = 3 
Query:  357 ANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPF-STYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            A+  S  S RFSP L+ H                     G+H     TGIP  +  S       +G ++ P  T    K    N+  E  KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  130 ASMSSLVSSRFSPHLVPHHPH------------------GLHQ----TGIPHPAIVSPVIKQEPNGELSPPVNT----KSPGPNKKDED-KKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY 270
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Xenopus
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:100493178])

HSP 1 Score: 159.073 bits (401), Expect = 5.027e-43
Identity = 78/124 (62.90%), Postives = 90/124 (72.58%), Query Frame = 3 
Query:  486 GQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            G + TGIP          +     ND     M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  224 GPHATGIPHPAIVNPQ-VKQEHPHND--NDLMHMKPHHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 344
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Xenopus
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:100493178])

HSP 1 Score: 159.073 bits (401), Expect = 5.684e-43
Identity = 78/126 (61.90%), Postives = 90/126 (71.43%), Query Frame = 3 
Query:  486 GQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYAC 863
            G + TGIP          +     ND     M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY  
Sbjct:  237 GPHATGIPHPAIVNPQ-VKQEHPHND--NDLMHMKPHHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYKA 359
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Xenopus
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:100493178])

HSP 1 Score: 157.532 bits (397), Expect = 4.278e-42
Identity = 71/93 (76.34%), Postives = 81/93 (87.10%), Query Frame = 3 
Query:  579 MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  251 MHMKPHHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 343
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Xenopus
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:395061])

HSP 1 Score: 153.68 bits (387), Expect = 6.996e-41
Identity = 68/79 (86.08%), Postives = 76/79 (96.20%), Query Frame = 3 
Query:  624 KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+RE+Q+KYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  246 KKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQSKYYELARKERQLHMQLYPGWSARDNYG 324
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Xenopus
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:395061])

HSP 1 Score: 154.836 bits (390), Expect = 1.197e-40
Identity = 68/78 (87.18%), Postives = 76/78 (97.44%), Query Frame = 3 
Query:  624 KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+RE+Q+KYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  246 KKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQSKYYELARKERQLHMQLYPGWSARDNY 323
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Mouse
Match: Lef1 (lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770])

HSP 1 Score: 160.999 bits (406), Expect = 3.336e-44
Identity = 79/136 (58.09%), Postives = 93/136 (68.38%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  179 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 305
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Mouse
Match: Lef1 (lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770])

HSP 1 Score: 160.614 bits (405), Expect = 1.097e-43
Identity = 79/135 (58.52%), Postives = 93/135 (68.89%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  217 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 342
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Mouse
Match: Lef1 (lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770])

HSP 1 Score: 160.614 bits (405), Expect = 1.658e-43
Identity = 79/136 (58.09%), Postives = 93/136 (68.38%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  245 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 371
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Mouse
Match: Lef1 (lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770])

HSP 1 Score: 160.229 bits (404), Expect = 1.821e-43
Identity = 79/135 (58.52%), Postives = 93/135 (68.89%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  217 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 342
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Mouse
Match: Tcf7 (transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507])

HSP 1 Score: 153.68 bits (387), Expect = 3.481e-43
Identity = 71/91 (78.02%), Postives = 81/91 (89.01%), Query Frame = 3 
Query:  585 LKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            LK     +  ++ KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:   81 LKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 171
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. UniProt/SwissProt
Match: sp|P27782|LEF1_MOUSE (Lymphoid enhancer-binding factor 1 OS=Mus musculus OX=10090 GN=Lef1 PE=1 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 1.159e-42
Identity = 79/136 (58.09%), Postives = 93/136 (68.38%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  245 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 371
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. UniProt/SwissProt
Match: sp|Q9QXN1|LEF1_RAT (Lymphoid enhancer-binding factor 1 OS=Rattus norvegicus OX=10116 GN=Lef1 PE=2 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 1.419e-42
Identity = 79/136 (58.09%), Postives = 93/136 (68.38%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  245 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPEHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 371
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. UniProt/SwissProt
Match: sp|Q9UJU2|LEF1_HUMAN (Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 1.526e-42
Identity = 79/135 (58.52%), Postives = 93/135 (68.89%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +PG P      G + TGIP          +     +      M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  247 IPGPP------GPHTTGIPHPAIVTPQVKQEHPHTDS---DLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 372
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. UniProt/SwissProt
Match: sp|Q9YHE8|T7L1A_DANRE (Transcription factor 7-like 1-A OS=Danio rerio OX=7955 GN=tcf7l1a PE=1 SV=1)

HSP 1 Score: 162.925 bits (411), Expect = 3.731e-42
Identity = 71/81 (87.65%), Postives = 79/81 (97.53%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  322 EEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY 402
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. UniProt/SwissProt
Match: sp|P70062|T7L1A_XENLA (Transcription factor 7-like 1-A OS=Xenopus laevis OX=8355 GN=tcf7l1-a PE=1 SV=1)

HSP 1 Score: 160.999 bits (406), Expect = 1.711e-41
Identity = 70/81 (86.42%), Postives = 78/81 (96.30%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYP WSARDNY
Sbjct:  317 EEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPSWSARDNY 397
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. TrEMBL
Match: A0A291LM08 (TCF-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 756.903 bits (1953), Expect = 0.000e+0
Identity = 446/446 (100.00%), Postives = 446/446 (100.00%), Query Frame = 3 
Query:  189 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRXXXXXXXXXXXXXXXXXXXXXHTIMDLS 1526
            GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS
Sbjct:    9 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS 454
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. TrEMBL
Match: A0A1S6KMJ0 (HMG box domain-containing protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 753.436 bits (1944), Expect = 0.000e+0
Identity = 445/446 (99.78%), Postives = 445/446 (99.78%), Query Frame = 3 
Query:  189 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRXXXXXXXXXXXXXXXXXXXXXHTIMDLS 1526
            GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNN VSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS
Sbjct:   15 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNGVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS 460
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. TrEMBL
Match: Q589S4 (HMG protein TCF/LEF (Fragment) OS=Dugesia japonica OX=6161 GN=03133HH PE=2 SV=1)

HSP 1 Score: 374.4 bits (960), Expect = 6.098e-124
Identity = 232/248 (93.55%), Postives = 238/248 (95.97%), Query Frame = 3 
Query:  681 RAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGN 1424
            R     ECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKR NSNNN+NNSKFH+SNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSL MSQGYFDGIPPRSILGATESLVNM+NN +NN VSSMISPMSGNPLGMLPTAGNLS DLDPYGLQYGAAALHNSLRQHQSLY+VGLTGMDAAISQA+KLEKFEGIISNSFMAGN
Sbjct:   13 RNSARGECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRANSNNNSNNSKFHASNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLSMSQGYFDGIPPRSILGATESLVNMTNNPSNNGVSSMISPMSGNPLGMLPTAGNLSTDLDPYGLQYGAAALHNSLRQHQSLYSVGLTGMDAAISQAMKLEKFEGIISNSFMAGN 260
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. TrEMBL
Match: A0A5J5DN18 (HMG box domain-containing protein (Fragment) OS=Etheostoma spectabile OX=54343 GN=FQN60_011851 PE=4 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 7.110e-43
Identity = 82/137 (59.85%), Postives = 97/137 (70.80%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTS--MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            VPG P      G + TGIP        +  N    ++P   +  M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:   36 VPGPP------GPHATGIPHP------AIVNPQVKHEPPHETDIMHMKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 160
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. TrEMBL
Match: A0A3L8SU60 (HMG box domain-containing protein (Fragment) OS=Chloebia gouldiae OX=44316 GN=DV515_00002580 PE=4 SV=1)

HSP 1 Score: 162.925 bits (411), Expect = 9.652e-43
Identity = 81/135 (60.00%), Postives = 94/135 (69.63%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            +PG P      G + TGIP          +     ND     M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  109 IPGPP------GPHTTGIPHPAIV-TPQVKQEHLHND--SELMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 234
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Cavefish
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:103033630])

HSP 1 Score: 162.925 bits (411), Expect = 1.141e-44
Identity = 82/138 (59.42%), Postives = 97/138 (70.29%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTS--MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            VPG P      G + TGIP        +  N    ++P   +  M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  218 VPGPP------GPHATGIPHP------AIVNPQVKHEPPHETDLMHMKSQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 343
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Cavefish
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:103033630])

HSP 1 Score: 162.54 bits (410), Expect = 2.426e-44
Identity = 82/137 (59.85%), Postives = 97/137 (70.80%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTS--MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            VPG P      G + TGIP        +  N    ++P   +  M +K        ++ K+PHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  218 VPGPP------GPHATGIPHP------AIVNPQVKHEPPHETDLMHMKSQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNY 342
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Cavefish
Match: tcf7l1b (transcription factor 7-like 1-B [Source:NCBI gene;Acc:103022374])

HSP 1 Score: 163.696 bits (413), Expect = 1.754e-43
Identity = 71/81 (87.65%), Postives = 79/81 (97.53%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  320 EEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY 400
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Cavefish
Match: tcf7l1b (transcription factor 7-like 1-B [Source:NCBI gene;Acc:103022374])

HSP 1 Score: 163.696 bits (413), Expect = 2.664e-43
Identity = 71/81 (87.65%), Postives = 79/81 (97.53%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  320 EEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY 400
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Cavefish
Match: tcf7l2 (transcription factor 7 like 2 [Source:NCBI gene;Acc:103031257])

HSP 1 Score: 157.532 bits (397), Expect = 4.952e-42
Identity = 69/77 (89.61%), Postives = 75/77 (97.40%), Query Frame = 3 
Query:  630 PHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            PHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  325 PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYV 401
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004973.1 (pep scaffold:Pmarinus_7.0:GL479925:4219:8952:-1 gene:ENSPMAG00000004519.1 transcript:ENSPMAT00000004973.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 86.2705 bits (212), Expect = 1.050e-20
Identity = 36/42 (85.71%), Postives = 41/42 (97.62%), Query Frame = 3 
Query:  732 QILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            QILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:    1 QILGRRWHALSREEQAKYYELARKERQLHSQLYPGWSARDNY 42
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008165.1 (pep scaffold:Pmarinus_7.0:GL479973:18969:29522:-1 gene:ENSPMAG00000007384.1 transcript:ENSPMAT00000008165.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 65.0846 bits (157), Expect = 1.476e-12
Identity = 28/74 (37.84%), Postives = 50/74 (67.57%), Query Frame = 3 
Query:  627 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSAR 848
            +PHIK+P+NAFM++ K+ R K++       +++I++ILG RW A++ +++  YYE   +  +LH + YPG+  R
Sbjct:   58 EPHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKAMSSQEKQPYYEEQARLSKLHLERYPGYKYR 131
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006684.1 (pep scaffold:Pmarinus_7.0:GL477399:28105:35473:-1 gene:ENSPMAG00000006026.1 transcript:ENSPMAT00000006684.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 4.024e-9
Identity = 25/72 (34.72%), Postives = 47/72 (65.28%), Query Frame = 3 
Query:  627 KPHIKKPLNAFMLFMKEMRAKVV-AECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            +PHIK+P+NAFM++ K+ R K++ A   +K +  I++  G RW +++ +++  YYE   +  +LH + YP +
Sbjct:   58 EPHIKRPMNAFMVWAKDERRKILQAFPDMKHTLQISECPGSRWKSMSNQEKQPYYEEQARLSKLHLEKYPDY 129
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010223.1 (pep scaffold:Pmarinus_7.0:GL478813:2555:9375:-1 gene:ENSPMAG00000009255.1 transcript:ENSPMAT00000010223.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 47.3654 bits (111), Expect = 2.747e-7
Identity = 23/74 (31.08%), Postives = 43/74 (58.11%), Query Frame = 3 
Query:  627 KPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSAR 848
            +P I +P+NAFM++ K+ R ++  +     +A ++++LG+ W ALT E +    E A + + LH   +P +  R
Sbjct:    3 EPRIPRPMNAFMVWAKDERRRLAKQNPDLHNAELSKMLGKSWRALTPESRRPCVEEAERLRLLHLSEHPDYKYR 76
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Sea Lamprey
Match: sox4b (SRY-box transcription factor 4b [Source:ZFIN;Acc:ZDB-GENE-040426-1274])

HSP 1 Score: 51.6026 bits (122), Expect = 2.818e-7
Identity = 25/77 (32.47%), Postives = 42/77 (54.55%), Query Frame = 3 
Query:  618 KTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSAR 848
            KT   HIK+P+NAFM++ +  R K++ +     +A I++ LGRRW  L   ++  +   A + +  H   YP +  R
Sbjct:   56 KTASGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGRRWKQLKESEKVPFIREAERLRLKHMADYPDYKYR 132
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Yeast
Match: ROX1 (Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance [Source:SGD;Acc:S000006269])

HSP 1 Score: 52.373 bits (124), Expect = 1.016e-7
Identity = 26/82 (31.71%), Postives = 45/82 (54.88%), Query Frame = 3 
Query:  618 KTKKPHIKKPLNAFMLFMKEMRAKVVAECT-----LKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSAR 848
            K+  P I +P NAF+LF +     ++ E T     +  ++ I++I+G +W  L  ED+A +  +A KEK  H + YP +  +
Sbjct:    4 KSSTPKIPRPKNAFILFRQHYHRILIDEWTAQGVEIPHNSNISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEYKYK 85
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Nematostella
Match: EDO32618 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUJ9])

HSP 1 Score: 145.206 bits (365), Expect = 9.349e-42
Identity = 67/85 (78.82%), Postives = 74/85 (87.06%), Query Frame = 3 
Query:  606 ENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            E   K +  HIKKPLNAFML+MK+MR KVVAECTLKESAAINQILG++WHAL R +QAKYYEMARKE+ LH QLYPGWSARDNYA
Sbjct:    2 ERDSKLQLQHIKKPLNAFMLYMKDMRPKVVAECTLKESAAINQILGKKWHALDRSEQAKYYEMARKERALHLQLYPGWSARDNYA 86
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Nematostella
Match: EDO33516 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRZ8])

HSP 1 Score: 55.8398 bits (133), Expect = 3.993e-10
Identity = 28/68 (41.18%), Postives = 42/68 (61.76%), Query Frame = 3 
Query:  636 IKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            IK+PLNAF+L+ K+ R  +  E     +  I++ LG  W  LT E++A Y+E A+K KE H + YP +
Sbjct:    6 IKRPLNAFILWSKKRRRVIANENPQMHNFDISRKLGLEWQKLTEEEKAYYFEEAKKLKEEHKERYPHY 73
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Nematostella
Match: EDO38755 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC09])

HSP 1 Score: 55.8398 bits (133), Expect = 4.729e-10
Identity = 23/73 (31.51%), Postives = 46/73 (63.01%), Query Frame = 3 
Query:  621 TKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            +KK H+K+P+N FM++ +E R +++ E     +A ++++LG  W  L+ E++  Y E A+   E+H + +P +
Sbjct:    3 SKKTHVKRPMNCFMVWSREKRCQILQENPGINNARLSKLLGMAWKKLSVEEKEPYIEKAKHLTEMHKEKHPDY 75
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Nematostella
Match: EDO47688 (Predicted protein; Sox family protein 2 [Source:UniProtKB/TrEMBL;Acc:Q3S383])

HSP 1 Score: 59.3066 bits (142), Expect = 4.977e-10
Identity = 23/69 (33.33%), Postives = 47/69 (68.12%), Query Frame = 3 
Query:  633 HIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            HIK+P+NA+M++ ++ R ++  EC    ++ I++ LG  W++LT +++  Y E A++ +ELH + +P +
Sbjct:    7 HIKRPMNAYMVWSRKERRRIAEECPRMLNSEISKRLGLEWNSLTLDEKQPYVEEAKRLRELHKKDHPDY 75
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Nematostella
Match: EDO32843 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STW6])

HSP 1 Score: 54.6842 bits (130), Expect = 1.210e-9
Identity = 25/80 (31.25%), Postives = 48/80 (60.00%), Query Frame = 3 
Query:  600 TNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGW 839
            T+E+ +K+   H+K+P+NAFM++ +  R K+  E     +A I++ LG+RW  L+  ++  + E + + +  H Q YP +
Sbjct:   11 THESKKKSDMQHVKRPMNAFMVWSQIERRKMAEEHPDMHNAEISKRLGKRWKLLSESEKRPFVEESERLRIRHMQAYPDY 90
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Medaka
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:101167344])

HSP 1 Score: 163.31 bits (412), Expect = 7.722e-45
Identity = 83/138 (60.14%), Postives = 97/138 (70.29%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTS--MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            VPG P      G + TGIP        +  N    ++P   +  M +K        ++ KKPHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  219 VPGPP------GPHATGIPHP------AIVNPQIKHEPPHETDIMHMKPQHEQRKEQEPKKPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 344
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Medaka
Match: lef1 (lymphoid enhancer binding factor 1 [Source:NCBI gene;Acc:101167344])

HSP 1 Score: 163.31 bits (412), Expect = 1.007e-44
Identity = 83/138 (60.14%), Postives = 97/138 (70.29%), Query Frame = 3 
Query:  453 VPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTS--MALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            VPG P      G + TGIP        +  N    ++P   +  M +K        ++ KKPHIKKPLNAFML+MKEMRA VVAECTLKESAAINQILGRRWHAL+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  213 VPGPP------GPHATGIPHP------AIVNPQIKHEPPHETDIMHMKPQHEQRKEQEPKKPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG 338
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Medaka
Match: tcf7l1 (transcription factor 7 like 1 [Source:NCBI gene;Acc:100820729])

HSP 1 Score: 163.31 bits (412), Expect = 3.222e-43
Identity = 71/82 (86.59%), Postives = 79/82 (96.34%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY 
Sbjct:  321 EEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYV 402
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Medaka
Match: tcf7 (transcription factor 7 [Source:NCBI gene;Acc:101162309])

HSP 1 Score: 159.073 bits (401), Expect = 3.365e-43
Identity = 78/126 (61.90%), Postives = 93/126 (73.81%), Query Frame = 3 
Query:  483 NGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            +G + TGIP       S  +     +D     M +K  +  +  ++ KKP IKKPLNAFML+MKEMRAKV+AECTLKESAAINQILGRRWHALTRE+QAKYYE+ARKE++LH QLYP WSARDNY 
Sbjct:  236 SGMHPTGIPHPAIVPPSGKQE----HDQYDRGMYVKQQVETKREKEPKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALTREEQAKYYELARKERQLHMQLYPTWSARDNYG 357
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Medaka
Match: tcf7l1 (transcription factor 7 like 1 [Source:NCBI gene;Acc:100820729])

HSP 1 Score: 162.925 bits (411), Expect = 4.375e-43
Identity = 71/81 (87.65%), Postives = 79/81 (97.53%), Query Frame = 3 
Query:  615 EKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNY 857
            E+ KKPHIKKPLNAFML+MKEMRAKVVAECTLKESAAINQILGRRWH+L+RE+QAKYYE+ARKE++LH QLYPGWSARDNY
Sbjct:  323 EEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNY 403
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 761.14 bits (1964), Expect = 0.000e+0
Identity = 448/451 (99.33%), Postives = 449/451 (99.56%), Query Frame = 3 
Query:  174 KTKIIGLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRXXXXXXXXXXXXXXXXXXXXXHTIMDLS 1526
            +TKIIGLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGL NENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNN VSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS
Sbjct:   11 QTKIIGLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNGVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS 461
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 760.755 bits (1963), Expect = 0.000e+0
Identity = 448/451 (99.33%), Postives = 449/451 (99.56%), Query Frame = 3 
Query:  174 KTKIIGLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRXXXXXXXXXXXXXXXXXXXXXHTIMDLS 1526
            +TKIIGLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGL NENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNN VSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS
Sbjct:   13 QTKIIGLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNGVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS 463
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 751.125 bits (1938), Expect = 0.000e+0
Identity = 444/446 (99.55%), Postives = 444/446 (99.55%), Query Frame = 3 
Query:  189 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRXXXXXXXXXXXXXXXXXXXXXHTIMDLS 1526
            GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGL NENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNN VSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS
Sbjct:   15 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNGVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS 460
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Planmine SMEST
Match: SMESG000009225.1 (SMESG000009225.1)

HSP 1 Score: 741.88 bits (1914), Expect = 0.000e+0
Identity = 428/446 (95.96%), Postives = 428/446 (95.96%), Query Frame = 3 
Query:  189 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACXXXXXXXXXXXXXXXXXXXXXXXXADCQGYNFMKKEKYSMPSAQWFKQACNXXXXXXXXXXXXXXXXXXXXXXXXXXGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRXXXXXXXXXXXXXXXXXXXXXHTIMDLS 1526
            GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGL NENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQA                TSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNN VSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS
Sbjct:   15 GLYRNSGVNYPLACNGPHTPHLNPLYGAPDFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLLNHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLANENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNSKFHSSNADCQGYNFMKKEKYSMPSAQWFKQAW---------------TSKSSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNGVSSMISPMSGNPLGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQAIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIMDLS 445
[Close]
BLAST of transcription factor 7-like 2 isoform X1 vs. Planmine SMEST
Match: SMESG000059443.1 (SMESG000059443.1)

HSP 1 Score: 167.548 bits (423), Expect = 2.265e-46
Identity = 111/196 (56.63%), Postives = 130/196 (66.33%), Query Frame = 3 
Query:  276 DFTSWQTAAAAAYGSPSSNIRSYYQSPANFISQNSGRFSPSLL-NHQNSVQNSHFYGFPEVPGNPMSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAEKTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTREDQAKYYEMARKEKELHHQLYPGWSARDNYA 860
            D  SW +        P  + R +  +   +  +N+G  SPSLL N   +V N+H     E P   + G H+  N   +  ST + + S  N  F   PS T  +L+     EN+EK KKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHAL+RE+QAKYYEMARKEKELHHQLYPGWSARDNYA
Sbjct:   47 DLASWNS------NPPLVDYRLFSSNNMRYGQRNNGNLSPSLLYNPLVNVSNNHLGCLTESPFTNLYGKHSSLNQYNLFHSTPNSSGS--NLSF---PS-TRNSLRFTFE-ENSEKPKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYEMARKEKELHHQLYPGWSARDNYA 229
The following BLAST results are available for this feature:
BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TCF71.639e-4478.02transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
TCF72.414e-4478.02transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
LEF13.770e-4458.52lymphoid enhancer binding factor 1 [Source:HGNC Sy... [more]
LEF11.851e-4358.52lymphoid enhancer binding factor 1 [Source:HGNC Sy... [more]
TCF72.157e-4378.02transcription factor 7 [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pop-14.254e-2457.32pep chromosome:WBcel235:I:2823254:2830311:-1 gene:... [more]
gei-35.911e-1135.21GEX Interacting protein [Source:UniProtKB/TrEMBL;... [more]
gei-38.927e-1135.21GEX Interacting protein [Source:UniProtKB/TrEMBL;... [more]
egl-132.063e-831.94Transcription factor egl-13 [Source:UniProtKB/Swi... [more]
egl-132.063e-831.94Transcription factor egl-13 [Source:UniProtKB/Swi... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pan1.444e-4079.78gene:FBgn0085432 transcript:FBtr0334301[more]
pan1.469e-4079.78gene:FBgn0085432 transcript:FBtr0112657[more]
pan1.669e-4079.78gene:FBgn0085432 transcript:FBtr0089161[more]
pan1.669e-4079.78gene:FBgn0085432 transcript:FBtr0089159[more]
pan1.669e-4079.78gene:FBgn0085432 transcript:FBtr0089162[more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef11.630e-4476.34lymphoid enhancer-binding factor 1 [Source:ZFIN;Ac... [more]
lef12.915e-4460.00lymphoid enhancer-binding factor 1 [Source:ZFIN;Ac... [more]
lef13.122e-4459.56lymphoid enhancer-binding factor 1 [Source:ZFIN;Ac... [more]
tcf7l1a3.462e-4487.65transcription factor 7 like 1a [Source:NCBI gene;A... [more]
tcf7l1b9.306e-4454.76transcription factor 7 like 1b [Source:NCBI gene;A... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef15.027e-4362.90lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
lef15.684e-4361.90lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
lef14.278e-4276.34lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf76.996e-4186.08transcription factor 7 [Source:NCBI gene;Acc:39506... [more]
tcf71.197e-4087.18transcription factor 7 [Source:NCBI gene;Acc:39506... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Lef13.336e-4458.09lymphoid enhancer binding factor 1 [Source:MGI Sym... [more]
Lef11.097e-4358.52lymphoid enhancer binding factor 1 [Source:MGI Sym... [more]
Lef11.658e-4358.09lymphoid enhancer binding factor 1 [Source:MGI Sym... [more]
Lef11.821e-4358.52lymphoid enhancer binding factor 1 [Source:MGI Sym... [more]
Tcf73.481e-4378.02transcription factor 7, T cell specific [Source:MG... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P27782|LEF1_MOUSE1.159e-4258.09Lymphoid enhancer-binding factor 1 OS=Mus musculus... [more]
sp|Q9QXN1|LEF1_RAT1.419e-4258.09Lymphoid enhancer-binding factor 1 OS=Rattus norve... [more]
sp|Q9UJU2|LEF1_HUMAN1.526e-4258.52Lymphoid enhancer-binding factor 1 OS=Homo sapiens... [more]
sp|Q9YHE8|T7L1A_DANRE3.731e-4287.65Transcription factor 7-like 1-A OS=Danio rerio OX=... [more]
sp|P70062|T7L1A_XENLA1.711e-4186.42Transcription factor 7-like 1-A OS=Xenopus laevis ... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A291LM080.000e+0100.00TCF-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
A0A1S6KMJ00.000e+099.78HMG box domain-containing protein OS=Schmidtea med... [more]
Q589S46.098e-12493.55HMG protein TCF/LEF (Fragment) OS=Dugesia japonica... [more]
A0A5J5DN187.110e-4359.85HMG box domain-containing protein (Fragment) OS=Et... [more]
A0A3L8SU609.652e-4360.00HMG box domain-containing protein (Fragment) OS=Ch... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef11.141e-4459.42lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
lef12.426e-4459.85lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf7l1b1.754e-4387.65transcription factor 7-like 1-B [Source:NCBI gene;... [more]
tcf7l1b2.664e-4387.65transcription factor 7-like 1-B [Source:NCBI gene;... [more]
tcf7l24.952e-4289.61transcription factor 7 like 2 [Source:NCBI gene;Ac... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000004973.11.050e-2085.71pep scaffold:Pmarinus_7.0:GL479925:4219:8952:-1 ge... [more]
ENSPMAT00000008165.11.476e-1237.84pep scaffold:Pmarinus_7.0:GL479973:18969:29522:-1 ... [more]
ENSPMAT00000006684.14.024e-934.72pep scaffold:Pmarinus_7.0:GL477399:28105:35473:-1 ... [more]
ENSPMAT00000010223.12.747e-731.08pep scaffold:Pmarinus_7.0:GL478813:2555:9375:-1 ge... [more]
sox4b2.818e-732.47SRY-box transcription factor 4b [Source:ZFIN;Acc:Z... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ROX11.016e-731.71Heme-dependent repressor of hypoxic genes; mediate... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO326189.349e-4278.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO335163.993e-1041.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387554.729e-1031.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476884.977e-1033.33Predicted protein; Sox family protein 2 [Source:U... [more]
EDO328431.210e-931.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lef17.722e-4560.14lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
lef11.007e-4460.14lymphoid enhancer binding factor 1 [Source:NCBI ge... [more]
tcf7l13.222e-4386.59transcription factor 7 like 1 [Source:NCBI gene;Ac... [more]
tcf73.365e-4361.90transcription factor 7 [Source:NCBI gene;Acc:10116... [more]
tcf7l14.375e-4387.65transcription factor 7 like 1 [Source:NCBI gene;Ac... [more]
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BLAST of transcription factor 7-like 2 isoform X1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000009225.10.000e+099.33SMESG000009225.1[more]
SMESG000009225.10.000e+099.33SMESG000009225.1[more]
SMESG000009225.10.000e+099.55SMESG000009225.1[more]
SMESG000009225.10.000e+095.96SMESG000009225.1[more]
SMESG000059443.12.265e-4656.63SMESG000059443.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002969 ID=SMED30002969|Name=transcription factor 7-like 2 isoform X1|organism=Schmidtea mediterranea sexual|type=transcript|length=1697bp
TTTGTTGTAGAACACAATATCCTTATTCTCTAAAATTAATGGAATTAAAT
ATCCAACGTTCACTTTGAGGCTCTTTTAGCTATAGAGCTTTAGAATATTT
GCATTTTCGAAAAATAACTTTATTTGAATTAAGGAAACGGAAACCGAATA
TAATTTTCTTTTGTTGATGATTAAAGACAAAAATAATAGGTTTGTATCGA
AATTCTGGAGTAAATTATCCTTTAGCATGTAATGGTCCCCATACTCCACA
TTTGAATCCCCTCTACGGTGCCCCTGATTTCACATCATGGCAAACTGCTG
CAGCTGCTGCATACGGTTCACCTTCATCAAATATTAGATCTTATTATCAA
AGTCCGGCAAATTTTATTTCTCAAAACAGTGGGCGATTTTCTCCTAGTTT
ACTCAATCATCAGAATAGTGTACAAAACAGTCATTTCTATGGATTCCCCG
AAGTCCCTGGCAACCCGATGAGTGGAATTCACAATGGCCAGAATCTCACG
GGAATTCCGTTCAGCACATATTCTGGTGCTTCATCATTTCGTAACAGTGG
ATTTGTAAATGATCCATCAAGAACATCAATGGCACTTAAGTTGGGTTTGA
CGAATGAAAATGCGGAAAAAACGAAAAAGCCCCATATCAAAAAACCATTG
AATGCCTTCATGTTGTTTATGAAAGAAATGAGAGCTAAAGTTGTCGCTGA
ATGTACATTGAAAGAATCGGCAGCTATTAACCAAATACTCGGTCGCAGAT
GGCACGCGTTGACTCGAGAAGACCAAGCGAAATACTATGAAATGGCAAGA
AAGGAAAAAGAGCTTCATCATCAGCTTTATCCAGGTTGGTCAGCCAGAGA
TAATTATGCTTGCAATATGAAGCGAAAAAAGAAGAGAGGGAATTCAAACA
ATAATAATAACAATTCTAAGTTCCATTCCTCAAATGCGGATTGCCAGGGT
TATAATTTCATGAAAAAAGAAAAATATTCAATGCCATCGGCTCAGTGGTT
CAAACAAGCTTGTAACTTCAGCGGAAGCGTAATATCTAGTTCTGATAATT
CTTCTAGGACCAGCAAATCCAGTCCATCTCTGCCAATGAGTCAAGGATAT
TTCGACGGTATTCCACCGAGATCGATTCTTGGAGCCACTGAATCTCTAGT
CAATATGTCCAACAATTCAACGAACAACTGCGTTTCATCAATGATTTCAC
CAATGTCTGGAAATCCACTAGGAATGCTACCGACAGCCGGGAATCTATCG
GCTGACCTTGATCCATACGGACTACAATATGGGGCCGCTGCGTTACACAA
TTCTTTGAGACAACATCAATCACTTTACAATGTCGGATTGACGGGGATGG
ATGCTGCAATCAGTCAAGCAATAAAACTGGAGAAATTTGAAGGAATCATC
AGCAACAGTTTCATGGCAGGCAATTCAGCATGCGATGATAGATCATTAGA
TGCCTCAACCTTGGTGTCATTGAGCTCATCTAGCAGTAATAACAATGTGT
TCTCTCACACTATAATGGATCTGTCATAGAAATCTTGATTTAATCAAACA
ACATAGAATAATAATGTATCATAGTTTTTTTTGTTAGCCATCTCATCTGA
ACTGATATATGTGAAAATGTGTAAATTTTCTTTATTTATTGTCGATATAT
TTATATACAAAGCATATTAAAATGTGATATGCAGTAATAAAGTTCGC
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protein sequence of SMED30002969-orf-1

>SMED30002969-orf-1 ID=SMED30002969-orf-1|Name=SMED30002969-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=354bp
MSGIHNGQNLTGIPFSTYSGASSFRNSGFVNDPSRTSMALKLGLTNENAE
KTKKPHIKKPLNAFMLFMKEMRAKVVAECTLKESAAINQILGRRWHALTR
EDQAKYYEMARKEKELHHQLYPGWSARDNYACNMKRKKKRGNSNNNNNNS
KFHSSNADCQGYNFMKKEKYSMPSAQWFKQACNFSGSVISSSDNSSRTSK
SSPSLPMSQGYFDGIPPRSILGATESLVNMSNNSTNNCVSSMISPMSGNP
LGMLPTAGNLSADLDPYGLQYGAAALHNSLRQHQSLYNVGLTGMDAAISQ
AIKLEKFEGIISNSFMAGNSACDDRSLDASTLVSLSSSSSNNNVFSHTIM
DLS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000044cephalic ganglia
PLANA:0000099neuron
PLANA:0000103central nervous system
PLANA:0000121stem cell
PLANA:0000418head
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036910HMG_box_dom_sf
IPR024940TCF/LEF
IPR009071HMG_box_dom
Vocabulary: biological process
TermDefinition
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0046621negative regulation of organ growth
GO:0046827positive regulation of protein export from nucleus
GO:0046889positive regulation of lipid biosynthetic process
GO:0048557embryonic digestive tract morphogenesis
GO:0048619embryonic hindgut morphogenesis
GO:0048625myoblast fate commitment
GO:0048641regulation of skeletal muscle tissue development
GO:0048660regulation of smooth muscle cell proliferation
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0001568blood vessel development
GO:0001678cellular glucose homeostasis
GO:0005977glycogen metabolic process
GO:0006006glucose metabolic process
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006357regulation of transcription from RNA polymerase II promoter
GO:0007050cell cycle arrest
GO:0008283cell proliferation
GO:0009267cellular response to starvation
GO:0009749response to glucose
GO:0009791post-embryonic development
GO:0010867positive regulation of triglyceride biosynthetic process
GO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003oligodendrocyte development
GO:0016055Wnt signaling pathway
GO:0021915neural tube development
GO:0021983pituitary gland development
GO:0030282bone mineralization
GO:0030514negative regulation of BMP signaling pathway
GO:0030538embryonic genitalia morphogenesis
GO:0031641regulation of myelination
GO:0032024positive regulation of insulin secretion
GO:0032092positive regulation of protein binding
GO:0032252secretory granule localization
GO:0032350regulation of hormone metabolic process
GO:0035019somatic stem cell population maintenance
GO:0035264multicellular organism growth
GO:0035411catenin import into nucleus
GO:0035947regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475odontogenesis of dentin-containing tooth
GO:0042593glucose homeostasis
GO:0043065positive regulation of apoptotic process
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043570maintenance of DNA repeat elements
GO:0043588skin development
GO:0044334canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045444fat cell differentiation
GO:0045599negative regulation of fat cell differentiation
GO:0045722positive regulation of gluconeogenesis
GO:0045892negative regulation of transcription, DNA-templated
GO:0045893positive regulation of transcription, DNA-templated
GO:0051897positive regulation of protein kinase B signaling
GO:0060070canonical Wnt signaling pathway
GO:0060325face morphogenesis
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090090negative regulation of canonical Wnt signaling pathway
GO:1901142insulin metabolic process
GO:2000675negative regulation of type B pancreatic cell apoptotic process
GO:2001237negative regulation of extrinsic apoptotic signaling pathway
GO:0048713regulation of oligodendrocyte differentiation
GO:0050679positive regulation of epithelial cell proliferation
Vocabulary: cellular component
TermDefinition
GO:0000790nuclear chromatin
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005667transcription factor complex
GO:0005829cytosol
GO:0016605PML body
GO:0032993protein-DNA complex
GO:0070369beta-catenin-TCF7L2 complex
GO:0071664catenin-TCF7L2 complex
Vocabulary: molecular function
TermDefinition
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding
GO:0001103RNA polymerase II repressing transcription factor binding
GO:0003677DNA binding
GO:0003682chromatin binding
GO:0003700transcription factor activity, sequence-specific DNA binding
GO:0005515protein binding
GO:0008013beta-catenin binding
GO:0008134transcription factor binding
GO:0019901protein kinase binding
GO:0035257nuclear hormone receptor binding
GO:0043565sequence-specific DNA binding
GO:0044212transcription regulatory region DNA binding
GO:0045295gamma-catenin binding
GO:0070016armadillo repeat domain binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009071High mobility group box domainSMARTSM00398hmgende2coord: 56..126
e-value: 5.6E-23
score: 92.3
IPR009071High mobility group box domainPFAMPF00505HMG_boxcoord: 57..124
e-value: 4.7E-22
score: 78.2
IPR009071High mobility group box domainPROSITEPS50118HMG_BOX_2coord: 57..125
score: 15.634
IPR036910High mobility group box domain superfamilyGENE3DG3DSA:1.10.30.10coord: 55..141
e-value: 4.4E-25
score: 89.9
IPR036910High mobility group box domain superfamilySUPERFAMILYSSF47095HMG-boxcoord: 56..135
IPR024940Transcription factor TCF/LEFPANTHERPTHR10373TRANSCRIPTION FACTOR 7 FAMILY MEMBERcoord: 46..237
NoneNo IPR availableCDDcd01388SOX-TCF_HMG-boxcoord: 56..127
e-value: 9.89168E-39
score: 130.496