GGACT domain-containing protein

Overview


Name	GGACT domain-containing protein
Smed ID	SMED30002944
Length (bp)	626

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of GGACT domain-containing protein (SMED30002944) t-SNE clustered cells

Violin plots show distribution of expression levels for GGACT domain-containing protein (SMED30002944) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GGACT domain-containing protein (SMED30002944) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GGACT domain-containing protein (SMED30002944) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30002944

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
Smed sexual biotype	SMED30002944	h1SMcG0021808	Contig54232	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30002944	h1SMcG0021808	Contig54232	newmark_ests	PMID:29674431 Fincher et al., 2018
pharynx	SMED30002944	h1SMcG0021808	dd_Smed_v4_8685_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30002944	h1SMcG0021808	dd_Smed_v4_8685_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30002944	h1SMcG0021808	dd_Smed_v4_8685_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30002944	h1SMcG0021808	dd_Smed_v4_8685_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30002944	h1SMcG0021808	dd_Smed_v6_8685_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
epidermis	SMED30002944	h1SMcG0021808	dd_Smed_v4_8685_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
dorsal ventral margin of the whole animal	SMED30002944	h1SMcG0021808	dd_Smed_v4_8685_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of GGACT domain-containing protein vs. Ensembl Human
Match: GGACT (gamma-glutamylamine cyclotransferase [Source:HGNC Symbol;Acc:HGNC:25100])

HSP 1 Score: 56.225 bits (134), Expect = 1.301e-9
Identity = 43/154 (27.92%), Postives = 68/154 (44.16%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLL---PIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVL----SALGNQK-----IFECWTYLLTDFKGEYIGYPCLEEY---------YNGRLNK 498
            M  +F+YG +KRG+  H +L         +   G   +  PL+IA ++N P+LL     G  V GE+Y + ++ +L  LD  E  P L +R +  V      A G ++       +C+ Y    F  E+   P  + Y         YN R N+
Sbjct:    1 MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSGRLVEGEVYAV-DERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR 153

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Query:  100 MTYLFIYGLMKRGESCHNLL---PIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVL----SALGNQK-----IFECWTYLLTDFKGEYIGYPCLEEY---------YNGRLNK 498
            M  +F+YG +KRG+  H +L         +   G   +  PL+IA ++N P+LL     G  V GE+Y + ++ +L  LD  E  P L +R +  V      A G ++       +C+ Y    F  E+   P  + Y         YN R N+
Sbjct:    1 MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSGRLVEGEVYAV-DERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR 153

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BLAST of GGACT domain-containing protein vs. Ensembl Celegans
Match: F42A10.9 (pep chromosome:WBcel235:III:6164645:6171165:1 gene:WBGene00023489.1 transcript:F42A10.9.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F42A10.9)

HSP 1 Score: 60.077 bits (144), Expect = 2.337e-11
Identity = 37/113 (32.74%), Postives = 60/113 (53.10%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIE--ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFK 441
            +F+YG +K GE  + +L     E  +I  G   +  PL++ +KYN PFLLD    G ++ GE+Y +  +  L  LD+LE +P L +RK   +    G  +    + YLL  ++
Sbjct:    7 VFVYGTLKTGEPNYKVLSETDGEYRFISSGTTVEKFPLVVGTKYNIPFLLDDAGNGNNIEGEMYEV-CEKKLKVLDELEAYPTLYDRKKVEIKLPSGTTET--AFIYLLKSWR 116

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BLAST of GGACT domain-containing protein vs. Ensembl Fly
Match: CG2811 (gene:FBgn0035082 transcript:FBtr0345515)

HSP 1 Score: 83.9593 bits (206), Expect = 1.911e-20
Identity = 49/150 (32.67%), Postives = 82/150 (54.67%), Query Frame = 1

Query:   97 IMTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILD 537
            +   +F+YG +KRGE  H+ L  +E     ++G G      PL++ ++YN PFLL     G H+ GE+Y + ++++LSKLD LE +P+  +R+  ++L  +   +  +CW YL+ +F  + +    L  Y+N           YNEN LD
Sbjct:    1 MAARVFVYGTLKRGEPNHHWLTKKENGQARFLGRGKTETKFPLVVGTRYNIPFLLARPGEGNHIEGEVYEV-DETMLSKLDILEDYPDYYDREQQTIL--MEQNETIQCWLYLIRNFPDKMLAKELLISYHN------TPERPYNENYLD 141

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BLAST of GGACT domain-containing protein vs. Ensembl Fly
Match: CG2811 (gene:FBgn0035082 transcript:FBtr0309243)

HSP 1 Score: 83.9593 bits (206), Expect = 2.261e-20
Identity = 49/150 (32.67%), Postives = 82/150 (54.67%), Query Frame = 1

Query:   97 IMTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILD 537
            +   +F+YG +KRGE  H+ L  +E     ++G G      PL++ ++YN PFLL     G H+ GE+Y + ++++LSKLD LE +P+  +R+  ++L  +   +  +CW YL+ +F  + +    L  Y+N           YNEN LD
Sbjct:    7 MAARVFVYGTLKRGEPNHHWLTKKENGQARFLGRGKTETKFPLVVGTRYNIPFLLARPGEGNHIEGEVYEV-DETMLSKLDILEDYPDYYDREQQTIL--MEQNETIQCWLYLIRNFPDKMLAKELLISYHN------TPERPYNENYLD 147

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BLAST of GGACT domain-containing protein vs. Ensembl Fly
Match: CG2811 (gene:FBgn0035082 transcript:FBtr0072412)

HSP 1 Score: 82.0333 bits (201), Expect = 1.218e-19
Identity = 43/132 (32.58%), Postives = 76/132 (57.58%), Query Frame = 1

Query:   97 IMTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYN 483
            +   +F+YG +KRGE  H+ L  +E     ++G G      PL++ ++YN PFLL     G H+ GE+Y + ++++LSKLD LE +P+  +R+  ++L  +   +  +CW YL+ +F  + +    L  Y+N
Sbjct:    7 MAARVFVYGTLKRGEPNHHWLTKKENGQARFLGRGKTETKFPLVVGTRYNIPFLLARPGEGNHIEGEVYEV-DETMLSKLDILEDYPDYYDREQQTIL--MEQNETIQCWLYLIRNFPDKMLAKELLISYHN 135

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BLAST of GGACT domain-containing protein vs. Ensembl Fly
Match: Tina-1 (gene:FBgn0035083 transcript:FBtr0072411)

HSP 1 Score: 65.4698 bits (158), Expect = 2.825e-13
Identity = 41/137 (29.93%), Postives = 71/137 (51.82%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKY 501
            ++ LF+YG +K G+  +++L         +  +   ++  PL+IA++YN PFLL+    G +V GEIY + +D +L+ LD LE   E+  R++  +   +G   +  CW YLL  +    +    L  Y N   + Y
Sbjct:   11 LSKLFVYGALKYGQPSNSILASSGNGFAKFWCKATTTQKLPLVIATRYNIPFLLNKPGVGYYVTGEIYEV-DDRMLNSLDNLEDCEEIYTREMHDMNIGVGEGTV-PCWVYLLQKYPENLLSLRYLSSYENSTTHPY 145

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BLAST of GGACT domain-containing protein vs. Ensembl Zebrafish
Match: ggact.1 (gamma-glutamylamine cyclotransferase, tandem duplicate 1 [Source:NCBI gene;Acc:777609])

HSP 1 Score: 59.3066 bits (142), Expect = 7.724e-11
Identity = 39/131 (29.77%), Postives = 64/131 (48.85%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIEELTYIGEGILSKIR--------PLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEY 477
            +F+YG +K+G+S ++     ELT    G    I         P++IA+K  +PFLL+    G  V GEIY ++ + +L  LD+ E  P+L +R    +    GN    E + Y  + F  +++  P    Y
Sbjct:   23 VFVYGTLKKGQSNYH-----ELTNTTHGQAEFITCARTKDPYPMVIATKDKFPFLLNVPGSGQQVYGEIYNVDQN-MLDFLDEFEECPDLYQRTSIQLKILKGNGDSEEAFVYSTSTFDPDWLNKPTFSVY 147

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BLAST of GGACT domain-containing protein vs. Ensembl Zebrafish
Match: ggact.3 (gamma-glutamylamine cyclotransferase, tandem duplicate 3 [Source:NCBI gene;Acc:100038780])

HSP 1 Score: 56.6102 bits (135), Expect = 5.094e-10
Identity = 39/130 (30.00%), Postives = 65/130 (50.00%), Query Frame = 1

Query:  106 YLFIYGLMKRGESCHNLLPIE---ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGN---QKIFECWTYLLTDFKGEYIGYPCLEEY 477
            ++F+YG +K+G+  H+ L      +  +I      +  PL+IA+K+N PFLL+    G  V GEIY ++   +L  LD  E  P+  +R    +    GN    +I E   Y   +F+ +++  P  E Y
Sbjct:    5 HVFVYGSLKKGQPNHHELLNSNNGQAEFITCAQTKEPYPLVIATKHNIPFLLNVPGSGKQVSGEIYSVDQ-KMLEFLDWFEKCPDWYQRTSIQLEILKGNGESGRIEEASVYSKINFEPDWLNKPTHESY 133

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Query:  106 YLFIYGLMKRGESCHNLLPIE---ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGN---QKIFECWTYLLTDFKGEYIGYPCLEEY 477
            ++F+YG +K+G+  H+ L      +  +I      +  PL+IA+K+N PFLL+    G  V GEIY ++   +L  LD  E  P+  +R    +    GN    +I E   Y   +F+ +++  P  E Y
Sbjct:    5 HVFVYGSLKKGQPNHHELLNSNNGQAEFITCAQTKEPYPLVIATKHNIPFLLNVPGSGKQVSGEIYSVDQ-KMLEFLDWFEKCPDWYQRTSIQLEILKGNGESGRIEEASVYSKINFEPDWLNKPTHESY 133

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Query:  106 YLFIYGLMKRGESCHNLLPIE---ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGN---QKIFECWTYLLTDFKGEYIGYPCLEEY 477
            ++F+YG +K+G+  H+ L      +  +I      +  PL+IA+K+N PFLL+    G  V GEIY ++   +L  LD  E  P+  +R    +    GN    +I E   Y   +F+ +++  P  E Y
Sbjct:    5 HVFVYGSLKKGQPNHHELLNSNNGQAEFITCAQTKEPYPLVIATKHNIPFLLNVPGSGKQVSGEIYSVDQ-KMLEFLDWFEKCPDWYQRTSIQLEILKGNGESGRIEEASVYSKINFEPDWLNKPTHESY 133

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BLAST of GGACT domain-containing protein vs. Ensembl Zebrafish
Match: ggact.2 (gamma-glutamylamine cyclotransferase, tandem duplicate 2 [Source:NCBI gene;Acc:447805])

HSP 1 Score: 53.5286 bits (127), Expect = 1.248e-8
Identity = 43/154 (27.92%), Postives = 73/154 (47.40%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIE---ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCS--VLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEY-YNGRLN-KYANVLNYNENILDE 540
            M  +F+YG +K+G+  +  L      +  +I      +  PL+I  + N PFLL+    G  V GEIY ++   +L  LD  E  P+  +R L    +L   G  ++ E + Y  T ++ +++  P  + Y  NG    KYA   +   + LD+
Sbjct:    1 MPLVFVYGTLKKGQPNYFRLIDSSNGQAEFITCARTVEPYPLVITGECNIPFLLNVPGSGQRVYGEIYSVDQ-KMLEFLDWFEECPDWYQRTLIQLEILKGNGETEVEEAFVYTKTKYEPDWLNKPTYDSYDSNGDHGLKYAYEEDMTRSTLDQ 153

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BLAST of GGACT domain-containing protein vs. Ensembl Xenopus
Match: GGACT (gamma-glutamylamine cyclotransferase [Source:NCBI gene;Acc:100379707])

HSP 1 Score: 56.9954 bits (136), Expect = 7.326e-10
Identity = 33/91 (36.26%), Postives = 50/91 (54.95%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPI---EELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNER 363
            MT +F+YG +KRG+  H ++      +  + G G   +  PL+IA + N PFLL+    G  + GEIY + +DS+L  LD  E  P   +R
Sbjct:    4 MTNIFVYGTLKRGQPNHTVMTCYKHGKAVFKGMGKTVEKYPLVIAEEANIPFLLNIPGTGRRIIGEIYSV-DDSMLQFLDDFEGCPNWYQR 93

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BLAST of GGACT domain-containing protein vs. Ensembl Mouse
Match: Ggact (gamma-glutamylamine cyclotransferase [Source:MGI Symbol;Acc:MGI:2385008])

HSP 1 Score: 55.4546 bits (132), Expect = 1.693e-9
Identity = 43/150 (28.67%), Postives = 69/150 (46.00%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKL--CSVLSALGNQKI---FECWTYLLTDFKGEYIGYPCLEEY---------YNGRLNK 498
            M ++F+YG +KRG+  H ++         + G G   +  PL+IA ++N P+LL     G  V GEIY + ++ +L  LD  E  P + +R      VL   G+       +C+ Y    +  E++  P  E Y         YN R N+
Sbjct:    1 MAHIFVYGTLKRGQPNHKVMLDHSHGLAAFRGRGCTVESFPLVIAGEHNIPWLLYLPGKGHCVTGEIYEV-DEQMLRFLDDFEDCPSMYQRTALQVQVLEWEGDGDPGDSVQCFVYTTATYAPEWLFLPYHESYDSEGPHGLRYNPRENR 149

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BLAST of GGACT domain-containing protein vs. Ensembl Mouse
Match: Ggact (gamma-glutamylamine cyclotransferase [Source:MGI Symbol;Acc:MGI:2385008])

HSP 1 Score: 51.6026 bits (122), Expect = 1.933e-8
Identity = 31/96 (32.29%), Postives = 50/96 (52.08%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSV 378
            M ++F+YG +KRG+  H ++         + G G   +  PL+IA ++N P+LL     G  V GEIY + ++ +L  LD  E  P + +R    V
Sbjct:    1 MAHIFVYGTLKRGQPNHKVMLDHSHGLAAFRGRGCTVESFPLVIAGEHNIPWLLYLPGKGHCVTGEIYEV-DEQMLRFLDDFEDCPSMYQRTALQV 95

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BLAST of GGACT domain-containing protein vs. Ensembl Mouse
Match: Ggact (gamma-glutamylamine cyclotransferase [Source:MGI Symbol;Acc:MGI:2385008])

HSP 1 Score: 51.6026 bits (122), Expect = 2.182e-8
Identity = 31/96 (32.29%), Postives = 50/96 (52.08%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSV 378
            M ++F+YG +KRG+  H ++         + G G   +  PL+IA ++N P+LL     G  V GEIY + ++ +L  LD  E  P + +R    V
Sbjct:    1 MAHIFVYGTLKRGQPNHKVMLDHSHGLAAFRGRGCTVESFPLVIAGEHNIPWLLYLPGKGHCVTGEIYEV-DEQMLRFLDDFEDCPSMYQRTALQV 95

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BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9W0Y2|YS11_DROME (Putative gamma-glutamylcyclotransferase CG2811 OS=Drosophila melanogaster OX=7227 GN=CG2811 PE=2 SV=2)

HSP 1 Score: 82.0333 bits (201), Expect = 1.221e-18
Identity = 43/132 (32.58%), Postives = 76/132 (57.58%), Query Frame = 1

Query:   97 IMTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYN 483
            +   +F+YG +KRGE  H+ L  +E     ++G G      PL++ ++YN PFLL     G H+ GE+Y + ++++LSKLD LE +P+  +R+  ++L  +   +  +CW YL+ +F  + +    L  Y+N
Sbjct:    7 MAARVFVYGTLKRGEPNHHWLTKKENGQARFLGRGKTETKFPLVVGTRYNIPFLLARPGEGNHIEGEVYEV-DETMLSKLDILEDYPDYYDREQQTIL--MEQNETIQCWLYLIRNFPDKMLAKELLISYHN 135

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BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9W0Y1|TINA1_DROME (Troponin C-akin-1 protein OS=Drosophila melanogaster OX=7227 GN=Tina-1 PE=2 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 2.832e-12
Identity = 41/137 (29.93%), Postives = 71/137 (51.82%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKY 501
            ++ LF+YG +K G+  +++L         +  +   ++  PL+IA++YN PFLL+    G +V GEIY + +D +L+ LD LE   E+  R++  +   +G   +  CW YLL  +    +    L  Y N   + Y
Sbjct:   11 LSKLFVYGALKYGQPSNSILASSGNGFAKFWCKATTTQKLPLVIATRYNIPFLLNKPGVGYYVTGEIYEV-DDRMLNSLDNLEDCEEIYTREMHDMNIGVGEGTV-PCWVYLLQKYPENLLSLRYLSSYENSTTHPY 145

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BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4KM86|GGACT_RAT (Gamma-glutamylaminecyclotransferase OS=Rattus norvegicus OX=10116 GN=Ggact PE=2 SV=1)

HSP 1 Score: 59.3066 bits (142), Expect = 3.725e-10
Identity = 43/150 (28.67%), Postives = 70/150 (46.67%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVL-----SALGNQKIFECWTYLLTDFKGEYIGYPCLEEY---------YNGRLNK 498
            M ++F+YG +KRG+  H ++  +     T+ G G   +  PL+IA ++N P+LL     G  V GEIY + ++ +L  LD  E  P + +R    V       A G     +C+ Y    +  E++  P  + Y         YN R N+
Sbjct:    1 MAHIFVYGTLKRGQPNHKVMLDQSHGLATFRGRGCTVESFPLVIAGEHNIPWLLHLPGKGHCVAGEIYEV-DEQMLRFLDDFEGCPSMYQRTALQVRVLEWEGAGGPGDSVQCFVYSTATYAPEWLFLPYHKNYDSEGPHGLRYNPRENR 149

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BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
Match: sp|A0JMM9|GGACA_DANRE (Gamma-glutamylaminecyclotransferase A OS=Danio rerio OX=7955 GN=ggact.1 PE=2 SV=1)

HSP 1 Score: 59.3066 bits (142), Expect = 5.713e-10
Identity = 39/131 (29.77%), Postives = 64/131 (48.85%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIEELTYIGEGILSKIR--------PLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEY 477
            +F+YG +K+G+S ++     ELT    G    I         P++IA+K  +PFLL+    G  V GEIY ++ + +L  LD+ E  P+L +R    +    GN    E + Y  + F  +++  P    Y
Sbjct:   23 VFVYGTLKKGQSNYH-----ELTNTTHGQAEFITCARTKDPYPMVIATKDKFPFLLNVPGSGQQVYGEIYNVDQN-MLDFLDEFEECPDLYQRTSIQLKILKGNGDSEEAFVYSTSTFDPDWLNKPTFSVY 147

[Close]

BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
Match: sp|A3KNL6|GGACC_DANRE (Gamma-glutamylaminecyclotransferase C OS=Danio rerio OX=7955 GN=ggact.3 PE=2 SV=1)

HSP 1 Score: 56.6102 bits (135), Expect = 3.845e-9
Identity = 39/130 (30.00%), Postives = 65/130 (50.00%), Query Frame = 1

Query:  106 YLFIYGLMKRGESCHNLLPIE---ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGN---QKIFECWTYLLTDFKGEYIGYPCLEEY 477
            ++F+YG +K+G+  H+ L      +  +I      +  PL+IA+K+N PFLL+    G  V GEIY ++   +L  LD  E  P+  +R    +    GN    +I E   Y   +F+ +++  P  E Y
Sbjct:    5 HVFVYGSLKKGQPNHHELLNSNNGQAEFITCAQTKEPYPLVIATKHNIPFLLNVPGSGKQVSGEIYSVDQ-KMLEFLDWFEKCPDWYQRTSIQLEILKGNGESGRIEEASVYSKINFEPDWLNKPTHESY 133

[Close]

BLAST of GGACT domain-containing protein vs. TrEMBL
Match: A0A2M4C199 (Putative troponin c-akin-1 protein (Fragment) OS=Anopheles marajoara OX=58244 PE=4 SV=1)

HSP 1 Score: 101.679 bits (252), Expect = 1.983e-23
Identity = 57/152 (37.50%), Postives = 85/152 (55.92%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLS-----ALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDE 540
            +F+YG +KRGE  H+ L        +++G G      PL+I S+YN PFLLD    G  VRGEIY I +D +L++LD LE +P L ER+  ++ S     A G +++  CW YLL  F    +  P LEEY N     Y    ++++++ D+
Sbjct:    6 VFVYGTLKRGEPNHHWLTDVANGMASFVGRGTTVARYPLVIGSRYNIPFLLDVPGRGHQVRGEIYEI-DDRMLTRLDVLEDYPRLYERRPEAIQSEGTAGATGGEQVVSCWIYLLQRFPPHLLEQPMLEEYRNSTALPYTE--SHDDDLFDD 154

[Close]

BLAST of GGACT domain-containing protein vs. TrEMBL
Match: A0A2M4C179 (Putative troponin c-akin-1 protein (Fragment) OS=Anopheles marajoara OX=58244 PE=4 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 5.480e-23
Identity = 57/152 (37.50%), Postives = 85/152 (55.92%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLS-----ALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDE 540
            +F+YG +KRGE  H+LL        +++G G      PL+I S+YN PFLLD    G  VRGEIY I +D +L++LD LE +P L ER+  ++ S     A G +++  CW YLL  F    +  P L EY N     Y    ++++++ D+
Sbjct:    6 VFVYGTLKRGEPNHHLLTDVANGMASFVGRGTTVARYPLVIGSRYNIPFLLDVPGRGHQVRGEIYDI-DDRMLTRLDVLEDYPRLYERRPEAIQSEGTAGATGGEEVVSCWIYLLQRFPPHLLEQPMLVEYRNSTALPYTE--SHDDDLFDD 154

[Close]

BLAST of GGACT domain-containing protein vs. TrEMBL
Match: A0A2M4C193 (Putative troponin c-akin-1 protein (Fragment) OS=Anopheles marajoara OX=58244 PE=4 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 9.155e-23
Identity = 58/157 (36.94%), Postives = 87/157 (55.41%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIEELTYIGEGILSKIR--------PLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLS-----ALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDE 540
            +F+YG +KRGE  H+ L     T +  G+ + +R        PL+I S+YN PFLLD    G  VRGEIY I +D +L++LD LE +P L ER+  ++ S     A G +++  CW YLL  F    +  P LEEY N     Y    ++++++ D+
Sbjct:    6 VFVYGTLKRGEPNHHWL-----TDVANGMANFVRRGTTVARYPLVIGSRYNIPFLLDVPGRGHQVRGEIYDI-DDRMLTRLDVLEDYPRLYERRPEAIQSEGTAEATGGEQVVSCWIYLLQRFPPHLLEQPMLEEYRNSTALPYTE--SHDDDLFDD 154

[Close]

BLAST of GGACT domain-containing protein vs. TrEMBL
Match: W5JL53 (Troponin C-akin-1 protein OS=Anopheles darlingi OX=43151 GN=AND_003130 PE=4 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 1.326e-22
Identity = 56/149 (37.58%), Postives = 83/149 (55.70%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPI---EELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLS--ALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDE 540
            +F+YG +K+GE  H+ L        +++G G      PL+I S+YN PFLLD    G  VRGEIY I +D +L++LD LE +P L ER+  ++ S    G  ++  CW YLL  F    +  P LEEY N     Y    ++++N+ D+
Sbjct:    7 VFVYGTLKQGEPNHHWLTDVANGRASFVGRGTTVARYPLVIGSRYNIPFLLDVPGRGHQVRGEIYDI-DDRMLARLDVLEDYPRLYERRPEAIQSEGKTGGTEVVSCWIYLLQRFPPALLEKPMLEEYRNSTALPYTE--SHDDNVFDD 152

[Close]

BLAST of GGACT domain-containing protein vs. TrEMBL
Match: A0A4C1UU70 (Gamma-glutamylcyclotransferase CG2811 OS=Eumeta variegata OX=151549 GN=EVAR_94610_1 PE=4 SV=1)

HSP 1 Score: 98.2117 bits (243), Expect = 2.029e-22
Identity = 57/126 (45.24%), Postives = 73/126 (57.94%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLLPIEE---LTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEY 477
            +F+YG +KR E  H  L   E     +IG G+     PLIIA+KYN PFLL +   G HVRGEIY + +D++LSKLD LE HP+  ER + S+L  +      +CW Y L  FK E I  P  E Y
Sbjct:    5 VFVYGTLKRDEPNHYWLTSPENGKSNFIGVGVTKTKYPLIIATKYNIPFLLYSPGKGHHVRGEIYEV-DDAMLSKLDILEDHPKFYERMIDSIL--INKSDTLDCWVYFLKSFKKECIDRPKYENY 127

[Close]

BLAST of GGACT domain-containing protein vs. Ensembl Cavefish
Match: ggact.3 (gamma-glutamylamine cyclotransferase [Source:NCBI gene;Acc:103030343])

HSP 1 Score: 59.6918 bits (143), Expect = 8.324e-11
Identity = 34/91 (37.36%), Postives = 54/91 (59.34%), Query Frame = 1

Query:  100 MTYLFIYGLMKRGESCHN-LLPIE--ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNER 363
            MT++F+YG +K+G+  H+ +L +   +  ++      +  PLIIA KYN PFLL+    G HV GEIY + ++ +L  LD  E  P + +R
Sbjct:   44 MTHVFVYGTLKKGQPNHDRMLDVSNGKSEFLCSASTVEKYPLIIAGKYNVPFLLNIPGTGQHVHGEIYSV-DEKMLKFLDWFESCPHMYQR 133

[Close]

BLAST of GGACT domain-containing protein vs. Ensembl Nematostella
Match: EDO33078 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STA6])

HSP 1 Score: 67.0106 bits (162), Expect = 3.277e-14
Identity = 43/137 (31.39%), Postives = 66/137 (48.18%), Query Frame = 1

Query:  109 LFIYGLMKRGESCHNLL--PIEELT-YIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANV 510
            +F+YG +K+G   H+LL  P+   T  +         PL++AS    PF++D    G  V+GE+Y +   + L  LDKLE HP    R+ C V++     ++  C  Y L + K   +    LEEY      +Y  V
Sbjct:    7 IFVYGTLKQGFPNHHLLSNPLSGTTKLLCSARTENCYPLVVASDAAIPFMMDIPGKGQRVKGEVYEVCPQA-LVHLDKLEDHPRWYRRQPCQVVTEDSEPELMSCEAYFLMNPKDSLLQKTFLEEYSLDCTKEYVRV 142

[Close]

BLAST of GGACT domain-containing protein vs. Ensembl Medaka
Match: ggact.3 (gamma-glutamylamine cyclotransferase [Source:NCBI gene;Acc:101169771])

HSP 1 Score: 61.2326 bits (147), Expect = 1.455e-11
Identity = 37/135 (27.41%), Postives = 70/135 (51.85%), Query Frame = 1

Query:   97 IMTYLFIYGLMKRGESCH-NLLPIE--ELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQK-----IFECWTYLLTDFKGEYIGYPCLEEY 477
            +M  +F+YG +KRG+  H  +L     +  ++   + ++  PL+IA++YN PFLL+    G  VRGEIY + ++ +L+ LD  E  P + +R +  +    G  +     I + + Y  T ++ ++      + Y
Sbjct:   30 LMPRVFVYGTLKRGQPNHYRMLDATNGKAEFLATALTTQRYPLVIATEYNIPFLLNLPGQGQRVRGEIYEV-DERMLAFLDAFESVPSMYQRTVVDLEVEDGGAELPPGSITQVFVYSTTSYQPDWPSGRSFQSY 163

[Close]

BLAST of GGACT domain-containing protein vs. Planmine SMEST
Match: SMESG000081395.1 (SMESG000081395.1)

HSP 1 Score: 283.108 bits (723), Expect = 9.861e-99
Identity = 140/142 (98.59%), Postives = 141/142 (99.30%), Query Frame = 1

Query:  127 MKRGESCHNLLPIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDEVKHI 552
            MKRGESCHNLLPIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTS GLHV+GEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDEVKHI
Sbjct:    1 MKRGESCHNLLPIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSRGLHVKGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDEVKHI 142

[Close]

BLAST of GGACT domain-containing protein vs. Planmine SMEST
Match: SMESG000022735.1 (SMESG000022735.1)

HSP 1 Score: 115.546 bits (288), Expect = 1.891e-32
Identity = 62/130 (47.69%), Postives = 86/130 (66.15%), Query Frame = 1

Query:  103 TYLFIYGLMKRGE-SCH---NLLPIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFE--CWTYLLTDFKGEYIGYPCLEE 474
             ++F+YG +K  E +CH   NL+  ++ +Y+G+G+L + RPLIIAS YN P+LLDTT  G HV+GEIY  + +  L  LD+LE HPE  ERK+C V+  L N    E  CW Y+LTDF  E + YP +E+
Sbjct:    6 NFIFVYGTLKSNEPNCHLMENLIICKKFSYVGKGVLKEKRPLIIASDYNLPYLLDTTGFGNHVKGEIYKYHTNDALVDLDRLEIHPEHYERKVCKVI-VLENDSFQELNCWVYILTDFVRELLIYPTIED 134

[Close]

BLAST of GGACT domain-containing protein vs. Planmine SMEST
Match: SMESG000022739.1 (SMESG000022739.1)

HSP 1 Score: 109.768 bits (273), Expect = 3.143e-30
Identity = 55/135 (40.74%), Postives = 83/135 (61.48%), Query Frame = 1

Query:   97 IMTYLFIYGLMKRGESCH----NLLPIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFE--CWTYLLTDFKGEYIGYPCLEEYYN 483
            +  Y+F+YG +K  +  H    NL+      Y+G+GI+ + RP+++A+++N P+LLD T  G  V+GEIY  ++   L+ LD+LE HP   ERK C ++  LG +   E  CW YLLT+FK E + YP + EY N
Sbjct:    1 MFNYIFVYGTLKSNQPNHYLIANLINKGLFQYLGDGIMKESRPMVVATEFNIPYLLDVTGAGYKVKGEIYSFDSQESLATLDELESHPTYYERKPCKIIK-LGCESNVEISCWVYLLTNFKSELLNYPYIAEYRN 134

[Close]

BLAST of GGACT domain-containing protein vs. Planmine SMEST
Match: SMESG000050178.1 (SMESG000050178.1)

HSP 1 Score: 94.3597 bits (233), Expect = 3.342e-24
Identity = 44/116 (37.93%), Postives = 73/116 (62.93%), Query Frame = 1

Query:  103 TYLFIYGLMK----RGESCHNLLPIEELTYIGEGILSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFECWTYLLTDF 438
            +Y+F+YG +K     G   + ++   ++ +IGEG++ + RPL++AS+ N+P++LD T  G +V+G+++ + +   L + D+ E HP   ERKLC +       KIF CWTYLL DF
Sbjct:    9 SYIFLYGTLKTVERNGFMTNKMISKNQIKFIGEGMMVEKRPLVVASRCNFPYILDVTGIGKNVKGQVFQLLDRYCLPEFDEFEDHPFYYERKLCRISLYNNKSKIFLCWTYLLPDF 124

[Close]

BLAST of GGACT domain-containing protein vs. Planmine SMEST
Match: SMESG000022739.1 (SMESG000022739.1)

HSP 1 Score: 88.9669 bits (219), Expect = 1.095e-22
Identity = 43/98 (43.88%), Postives = 63/98 (64.29%), Query Frame = 1

Query:  196 LSKIRPLIIASKYNYPFLLDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQKIFE--CWTYLLTDFKGEYIGYPCLEEYYN 483
            + + RP+++A+++N P+LLD T  G  V+GEIY  ++   L+ LD+LE HP   ERK C ++  LG +   E  CW YLLT+FK E + YP + EY N
Sbjct:    1 MKESRPMVVATEFNIPYLLDVTGAGYKVKGEIYSFDSQESLATLDELESHPTYYERKPCKIIK-LGCESNVEISCWVYLLTNFKSELLNYPYIAEYRN 97

The following BLAST results are available for this feature:

BLAST of GGACT domain-containing protein vs. Ensembl Human
BLAST of GGACT domain-containing protein vs. Ensembl Celegans
BLAST of GGACT domain-containing protein vs. Ensembl Fly
BLAST of GGACT domain-containing protein vs. Ensembl Zebrafish
BLAST of GGACT domain-containing protein vs. Ensembl Xenopus
BLAST of GGACT domain-containing protein vs. Ensembl Mouse
BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
BLAST of GGACT domain-containing protein vs. TrEMBL
BLAST of GGACT domain-containing protein vs. Ensembl Cavefish
BLAST of GGACT domain-containing protein vs. Ensembl Sea Lamprey
BLAST of GGACT domain-containing protein vs. Ensembl Yeast
BLAST of GGACT domain-containing protein vs. Ensembl Nematostella
BLAST of GGACT domain-containing protein vs. Ensembl Medaka
BLAST of GGACT domain-containing protein vs. Planmine SMEST

BLAST of GGACT domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
GGACT	1.301e-9	27.92	gamma-glutamylamine cyclotransferase [Source:HGNC ...	[more]
GGACT	1.301e-9	27.92	gamma-glutamylamine cyclotransferase [Source:HGNC ...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
F42A10.9	2.337e-11	32.74	pep chromosome:WBcel235:III:6164645:6171165:1 gene...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
CG2811	1.911e-20	32.67	gene:FBgn0035082 transcript:FBtr0345515	[more]
CG2811	2.261e-20	32.67	gene:FBgn0035082 transcript:FBtr0309243	[more]
CG2811	1.218e-19	32.58	gene:FBgn0035082 transcript:FBtr0072412	[more]
Tina-1	2.825e-13	29.93	gene:FBgn0035083 transcript:FBtr0072411	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ggact.1	7.724e-11	29.77	gamma-glutamylamine cyclotransferase, tandem dupli...	[more]
ggact.3	5.094e-10	30.00	gamma-glutamylamine cyclotransferase, tandem dupli...	[more]
ggact.3	5.094e-10	30.00	gamma-glutamylamine cyclotransferase, tandem dupli...	[more]
ggact.3	5.094e-10	30.00	gamma-glutamylamine cyclotransferase, tandem dupli...	[more]
ggact.2	1.248e-8	27.92	gamma-glutamylamine cyclotransferase, tandem dupli...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
GGACT	7.326e-10	36.26	gamma-glutamylamine cyclotransferase [Source:NCBI ...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Ggact	1.693e-9	28.67	gamma-glutamylamine cyclotransferase [Source:MGI S...	[more]
Ggact	1.933e-8	32.29	gamma-glutamylamine cyclotransferase [Source:MGI S...	[more]
Ggact	2.182e-8	32.29	gamma-glutamylamine cyclotransferase [Source:MGI S...	[more]

BLAST of GGACT domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9W0Y2\|YS11_DROME	1.221e-18	32.58	Putative gamma-glutamylcyclotransferase CG2811 OS=...	[more]
sp\|Q9W0Y1\|TINA1_DROME	2.832e-12	29.93	Troponin C-akin-1 protein OS=Drosophila melanogast...	[more]
sp\|Q4KM86\|GGACT_RAT	3.725e-10	28.67	Gamma-glutamylaminecyclotransferase OS=Rattus norv...	[more]
sp\|A0JMM9\|GGACA_DANRE	5.713e-10	29.77	Gamma-glutamylaminecyclotransferase A OS=Danio rer...	[more]
sp\|A3KNL6\|GGACC_DANRE	3.845e-9	30.00	Gamma-glutamylaminecyclotransferase C OS=Danio rer...	[more]

BLAST of GGACT domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2M4C199	1.983e-23	37.50	Putative troponin c-akin-1 protein (Fragment) OS=A...	[more]
A0A2M4C179	5.480e-23	37.50	Putative troponin c-akin-1 protein (Fragment) OS=A...	[more]
A0A2M4C193	9.155e-23	36.94	Putative troponin c-akin-1 protein (Fragment) OS=A...	[more]
W5JL53	1.326e-22	37.58	Troponin C-akin-1 protein OS=Anopheles darlingi OX...	[more]
A0A4C1UU70	2.029e-22	45.24	Gamma-glutamylcyclotransferase CG2811 OS=Eumeta va...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ggact.3	8.324e-11	37.36	gamma-glutamylamine cyclotransferase [Source:NCBI ...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of GGACT domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of GGACT domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO33078	3.277e-14	31.39	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of GGACT domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ggact.3	1.455e-11	27.41	gamma-glutamylamine cyclotransferase [Source:NCBI ...	[more]

BLAST of GGACT domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000081395.1	9.861e-99	98.59	SMESG000081395.1	[more]
SMESG000022735.1	1.891e-32	47.69	SMESG000022735.1	[more]
SMESG000022739.1	3.143e-30	40.74	SMESG000022739.1	[more]
SMESG000050178.1	3.342e-24	37.93	SMESG000050178.1	[more]
SMESG000022739.1	1.095e-22	43.88	SMESG000022739.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30002944 ID=SMED30002944|Name=GGACT domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=626bp
TAGTGATTTTATTTTTAATTTATTATTGCTATTTTATTCTAACCCTAACT
ATACATTTTATAATTATATAGGCTATCTTTTTTCATTTTTTAATTCATTA
TGACTTATTTATTTATTTATGGTTTAATGAAACGAGGTGAAAGTTGTCAC
AATTTATTACCAATAGAAGAATTGACATATATTGGTGAAGGAATATTATC
TAAAATAAGACCATTAATTATTGCATCAAAATATAATTACCCTTTCTTAT
TGGACACTACAAGTTGTGGACTGCATGTTAGAGGTGAAATTTATATAATA
AATAATGACTCTGTTCTTTCGAAATTGGATAAATTGGAACATCATCCTGA
ATTAAATGAAAGAAAATTATGTTCTGTGTTGAGTGCACTTGGTAATCAAA
AGATATTTGAGTGTTGGACTTATTTGCTAACTGATTTCAAAGGAGAATAT
ATTGGGTATCCATGCCTAGAAGAATATTATAATGGTCGATTAAATAAATA
TGCGAATGTTTTGAATTATAATGAAAATATTTTGGATGAAGTTAAACATA
TTTAAATTTTTTGAATCTCACTTAGATGTCTAACAATATATTTAACATGT
TCGATTTTGCCTTCGTATTATTAAAA

protein sequence of SMED30002944-orf-1

>SMED30002944-orf-1 ID=SMED30002944-orf-1|Name=SMED30002944-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=152bp
MTYLFIYGLMKRGESCHNLLPIEELTYIGEGILSKIRPLIIASKYNYPFL
LDTTSCGLHVRGEIYIINNDSVLSKLDKLEHHPELNERKLCSVLSALGNQ
KIFECWTYLLTDFKGEYIGYPCLEEYYNGRLNKYANVLNYNENILDEVKH
I*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR039126	GGACT
IPR036568	GGCT-like_sf
IPR013024	GGCT-like
IPR009288	AIG2-like

Vocabulary: **molecular function**
Term	Definition
GO:0016740	transferase activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR009288	Gamma-glutamylcyclotransferase, AIG2-like	PFAM	PF06094	GGACT	coord: 4..112 e-value: 1.1E-12 score: 48.6
None	No IPR available	GENE3D	G3DSA:3.10.490.10		coord: 1..142 e-value: 6.7E-26 score: 92.9
None	No IPR available	PANTHER	PTHR12510:SF4	GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE	coord: 1..118
IPR039126	Gamma-glutamylaminecyclotransferase	PANTHER	PTHR12510	TROPONIN C-AKIN-1 PROTEIN	coord: 1..118
IPR013024	Gamma-glutamyl cyclotransferase-like	CDD	cd06661	GGCT_like	coord: 4..110 e-value: 2.02905E-9 score: 49.6506
IPR036568	Gamma-glutamyl cyclotransferase-like superfamily	SUPERFAMILY	SSF110857	Gamma-glutamyl cyclotransferase-like	coord: 1..131

Main menu

GGACT domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Owlery

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