Cyclin-dependent kinase 12
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002908 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK12 (cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]) HSP 1 Score: 479.174 bits (1232), Expect = 3.113e-151 Identity = 224/351 (63.82%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 699 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1048
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK12 (cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]) HSP 1 Score: 479.559 bits (1233), Expect = 5.958e-149 Identity = 224/351 (63.82%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 700 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1049
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK12 (cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]) HSP 1 Score: 478.789 bits (1231), Expect = 1.076e-148 Identity = 224/351 (63.82%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 700 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1049
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK13 (cyclin dependent kinase 13 [Source:HGNC Symbol;Acc:HGNC:1733]) HSP 1 Score: 472.626 bits (1215), Expect = 1.224e-146 Identity = 219/351 (62.39%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKR--SATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDE-QVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R ++ WG+R V F I +GEGTYG V+KA D TGE+ ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDFKKDKGAFYLVF+YMDHDL G+LES V +E + S +QL+EG+ YCH +NFLHRDIKCSNIL+NNRG+IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+R+LRE + +P+ ALDL D+ML LDP KRCTA QAL+ ++LR+V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 678 RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRR 1027
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK13 (cyclin dependent kinase 13 [Source:HGNC Symbol;Acc:HGNC:1733]) HSP 1 Score: 473.396 bits (1217), Expect = 1.898e-146 Identity = 219/351 (62.39%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKR--SATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDE-QVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R ++ WG+R V F I +GEGTYG V+KA D TGE+ ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDFKKDKGAFYLVF+YMDHDL G+LES V +E + S +QL+EG+ YCH +NFLHRDIKCSNIL+NNRG+IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+R+LRE + +P+ ALDL D+ML LDP KRCTA QAL+ ++LR+V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 678 RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRR 1027
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-12 (Cyclin-dependent kinase 12 [Source:UniProtKB/Swiss-Prot;Acc:P46551]) HSP 1 Score: 395.971 bits (1016), Expect = 5.563e-125 Identity = 189/367 (51.50%), Postives = 264/367 (71.93%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT----WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVI--TDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHY-CTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKA 2099
+ +P I +R N + W + +++ + +D++GEGTYG V+KA + TGE ALK+VRLENEKEGFPITAIREIKIL QL H NIV L +IV D + + K+ + FYLVF+Y+DHDL G+LESK ++ +Q+ S+FKQLLEG+ Y H+ FLHRDIKCSNILVNN+GE+K+AD GLARL+ + + R YTN+VITLWYRPPELLLG+E Y PAID+WS GC+LGELFT + +F + E Q+E ISKVCG PNV++WP++T L + +++ + Y+RR+RE + +P A+DLLD ML L+PEKR +A +AL W+R+++ ++P P+ +DCHE+ SKK++K R ++ +
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLW--EKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEMWSKKQKKSARLGRQAEG 644
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-12 (Cyclin-dependent kinase 12 [Source:UniProtKB/Swiss-Prot;Acc:P46551]) HSP 1 Score: 395.971 bits (1016), Expect = 6.360e-125 Identity = 189/367 (51.50%), Postives = 264/367 (71.93%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT----WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVI--TDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHY-CTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKA 2099
+ +P I +R N + W + +++ + +D++GEGTYG V+KA + TGE ALK+VRLENEKEGFPITAIREIKIL QL H NIV L +IV D + + K+ + FYLVF+Y+DHDL G+LESK ++ +Q+ S+FKQLLEG+ Y H+ FLHRDIKCSNILVNN+GE+K+AD GLARL+ + + R YTN+VITLWYRPPELLLG+E Y PAID+WS GC+LGELFT + +F + E Q+E ISKVCG PNV++WP++T L + +++ + Y+RR+RE + +P A+DLLD ML L+PEKR +A +AL W+R+++ ++P P+ +DCHE+ SKK++K R ++ +
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLW--EKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEMWSKKQKKSARLGRQAEG 644
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-12 (Cyclin-dependent kinase 12 [Source:UniProtKB/Swiss-Prot;Acc:P46551]) HSP 1 Score: 395.586 bits (1015), Expect = 6.826e-125 Identity = 189/367 (51.50%), Postives = 264/367 (71.93%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT----WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVI--TDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHY-CTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKA 2099
+ +P I +R N + W + +++ + +D++GEGTYG V+KA + TGE ALK+VRLENEKEGFPITAIREIKIL QL H NIV L +IV D + + K+ + FYLVF+Y+DHDL G+LESK ++ +Q+ S+FKQLLEG+ Y H+ FLHRDIKCSNILVNN+GE+K+AD GLARL+ + + R YTN+VITLWYRPPELLLG+E Y PAID+WS GC+LGELFT + +F + E Q+E ISKVCG PNV++WP++T L + +++ + Y+RR+RE + +P A+DLLD ML L+PEKR +A +AL W+R+++ ++P P+ +DCHE+ SKK++K R ++ +
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLW--EKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEMWSKKQKKSARLGRQAEG 644
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-9 (Probable cyclin-dependent kinase 9 [Source:UniProtKB/Swiss-Prot;Acc:Q9TVL3]) HSP 1 Score: 244.202 bits (622), Expect = 1.319e-71 Identity = 126/334 (37.72%), Postives = 189/334 (56.59%), Query Frame = 3
Query: 1086 RSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKK---RP-YTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYK-------PRHNYK-----------------------RRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
R VS + ++K+G+GT+G VFKA TG + ALKK+ +ENEKEGFPITA+RE+K+L QL H NI +L E+ + KD+ FYLV HDL G+L + + ++ + ++ K L+ G+ H LHRD+K +N+L++ G +KLADFGLAR ++ + RP YTN+V+TLWYRPPELLLG+ Y ID+W GCI+ E++T Q + E +Q++ IS +CG N + WP +PL+ + P+ Y+ + +++H AL LL+ +L +DP+KR T+ +A W
Sbjct: 80 RDVSTYEKLNKIGQGTFGEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF 413
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-9 (Probable cyclin-dependent kinase 9 [Source:UniProtKB/Swiss-Prot;Acc:Q9TVL3]) HSP 1 Score: 244.973 bits (624), Expect = 1.667e-71 Identity = 126/334 (37.72%), Postives = 189/334 (56.59%), Query Frame = 3
Query: 1086 RSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKK---RP-YTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYK-------PRHNYK-----------------------RRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
R VS + ++K+G+GT+G VFKA TG + ALKK+ +ENEKEGFPITA+RE+K+L QL H NI +L E+ + KD+ FYLV HDL G+L + + ++ + ++ K L+ G+ H LHRD+K +N+L++ G +KLADFGLAR ++ + RP YTN+V+TLWYRPPELLLG+ Y ID+W GCI+ E++T Q + E +Q++ IS +CG N + WP +PL+ + P+ Y+ + +++H AL LL+ +L +DP+KR T+ +A W
Sbjct: 80 RDVSTYEKLNKIGQGTFGEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF 413
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk12 (gene:FBgn0037093 transcript:FBtr0078357) HSP 1 Score: 449.514 bits (1155), Expect = 1.136e-140 Identity = 224/357 (62.75%), Postives = 278/357 (77.87%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT-WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKE 2090
++P I +R +RNNV WGER V F I ++GEGTYG V+KA D T ++ ALKKVRLE+EKEGFPITA+REIKIL QL H NIVNL EIVTD +A++F+KDKG+FYLVF+YMDHDL G+LES V +E ASI KQLL+G+ YCH +NFLHRDIKCSNIL+NNRG++KLADFGLARLY ADD++RPYTNKVITLWYRPPELLLGEE Y P+ID+WS GCILGELF + +F A+ EM Q+E+ISK+CG P WP V +LPLF + K + ++RRLRE + +P+ ALDLLD ML LDP+KR TA AL+S WLR ++ ++ P P +DCHEL SKKRR+ MR+++E
Sbjct: 779 QRPVILNRRD-SRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQE 1134
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk12 (gene:FBgn0037093 transcript:FBtr0332716) HSP 1 Score: 449.514 bits (1155), Expect = 1.136e-140 Identity = 224/357 (62.75%), Postives = 278/357 (77.87%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT-WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKE 2090
++P I +R +RNNV WGER V F I ++GEGTYG V+KA D T ++ ALKKVRLE+EKEGFPITA+REIKIL QL H NIVNL EIVTD +A++F+KDKG+FYLVF+YMDHDL G+LES V +E ASI KQLL+G+ YCH +NFLHRDIKCSNIL+NNRG++KLADFGLARLY ADD++RPYTNKVITLWYRPPELLLGEE Y P+ID+WS GCILGELF + +F A+ EM Q+E+ISK+CG P WP V +LPLF + K + ++RRLRE + +P+ ALDLLD ML LDP+KR TA AL+S WLR ++ ++ P P +DCHEL SKKRR+ MR+++E
Sbjct: 779 QRPVILNRRD-SRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQE 1134
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk12 (gene:FBgn0037093 transcript:FBtr0078358) HSP 1 Score: 449.514 bits (1155), Expect = 1.136e-140 Identity = 224/357 (62.75%), Postives = 278/357 (77.87%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT-WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKE 2090
++P I +R +RNNV WGER V F I ++GEGTYG V+KA D T ++ ALKKVRLE+EKEGFPITA+REIKIL QL H NIVNL EIVTD +A++F+KDKG+FYLVF+YMDHDL G+LES V +E ASI KQLL+G+ YCH +NFLHRDIKCSNIL+NNRG++KLADFGLARLY ADD++RPYTNKVITLWYRPPELLLGEE Y P+ID+WS GCILGELF + +F A+ EM Q+E+ISK+CG P WP V +LPLF + K + ++RRLRE + +P+ ALDLLD ML LDP+KR TA AL+S WLR ++ ++ P P +DCHEL SKKRR+ MR+++E
Sbjct: 779 QRPVILNRRD-SRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQE 1134
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk9 (gene:FBgn0019949 transcript:FBtr0071937) HSP 1 Score: 235.728 bits (600), Expect = 7.688e-69 Identity = 116/259 (44.79%), Postives = 170/259 (65.64%), Query Frame = 3
Query: 1110 IDKVGEGTYGHVFKAEDIQTGE-LKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYI--ADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLRE 1874
+ K+G+GT+G VFKA + + + A+KKV ++NEKEGFPITA+REI+IL L H N+VNL EI A + + FYLVFD+ +HDL G+L + +V + ++ + +QLL G+ Y HS LHRD+K +N+L+ G +KLADFGLAR + ++ K YTN+V+TLWYRPPELLLG+ Y P +D+W GCI+ E++T + + E +Q+ IS++CG + WP V L L++S + N KRR++E
Sbjct: 53 VAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATN--GYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKE 309
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk2 (gene:FBgn0004107 transcript:FBtr0083922) HSP 1 Score: 226.868 bits (577), Expect = 9.264e-67 Identity = 125/301 (41.53%), Postives = 183/301 (60.80%), Query Frame = 3
Query: 1101 FRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKS-VITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPR---HNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNV 1991
F+ +K+GEGTYG V+KA TG+ ALKK+RLE E EG P TAIREI +L L H N+V L ++V +N Y++F+Y++ DL +++ K V T + + S Q+L+ + +CH+ LHRD+K N+LV+ G+IKLADFGLAR + + R YT++V+TLWYR PE+LLG + YS +DIWSLGCI E+ +++F E++Q+ I + P+ +WP VT+LP F++ PR N + + EH A +L+ ML DP R +A AL+ + RNV
Sbjct: 8 FQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGNN----------LYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAF--NVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQPITEH------EAHELIMSMLCYDPNLRISAKDALQHAYFRNV 290
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk12 (cyclin-dependent kinase 12 [Source:ZFIN;Acc:ZDB-GENE-081104-294]) HSP 1 Score: 475.322 bits (1222), Expect = 4.386e-149 Identity = 226/354 (63.84%), Postives = 271/354 (76.55%), Query Frame = 3
Query: 1017 SLMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
S K+P IC+ R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V + E V S +QL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE YSPAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V RLP F + +P+ Y+RRLRE + LP+ ALDLLD ML LDP +RCTA QAL S +L +V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 645 SFKKRPKICSPRYGERKQTQTDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVSFSHEHVQSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAAWPDVIRLPYFNTMRPKKQYRRRLREEFSFLPTPALDLLDHMLTLDPSRRCTAEQALASQFLCDVEPNKMPPPDLPHWQDCHELWSKKRRR 997
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk13 (cyclin-dependent kinase 13 [Source:ZFIN;Acc:ZDB-GENE-030131-4975]) HSP 1 Score: 470.315 bits (1209), Expect = 2.825e-147 Identity = 225/363 (61.98%), Postives = 273/363 (75.21%), Query Frame = 3
Query: 1026 KKPGICAKRSA--TRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHK 2105
++P IC R + WG+R V F I GEGTYG V+KA+D T EL ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDFK DKGAFYLVF+YMDHDL G+LES V + + S +QLLEG+ YCH +NFLHRDIKCSNIL+NN+G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P ALDL D ML LDP KRCTA QAL SD+LR+VD K+ PPD P +DCHEL SKKRR+ + +EL A K
Sbjct: 567 RRPKICGPRFGEIKETEIDWGKRCVDKFEIIGITGEGTYGQVYKAKDKDTAELVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALDFKNDKGAFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFAFIPLMALDLFDHMLALDPSKRCTAEQALNSDFLRDVDPAKMPPPDLPLWQDCHELWSKKRRRQKQMPEELTAPK 928
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 257.299 bits (656), Expect = 4.258e-77 Identity = 135/303 (44.55%), Postives = 189/303 (62.38%), Query Frame = 3
Query: 1095 SAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLY--IADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKV-TRLPLFESYKPRHNYKRRLREH---YCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
S + + K+G+GT+G VFKA+ QTG+ ALKKV +ENEKEGFPITA+REIKIL L H N+VNL EI A F + KG+ YLVFD+ +HDL G+L + +V T ++ + + LL G+ Y H LHRD+K +N+L+ G +KLADFGLAR + + + YTN+V+TLWYRPPELLLGE Y P ID+W GCI+ E++T + + E Q+ IS++CG WP V + L++ + KR++++ Y P ALDL+D +L LDP +R + AL D+
Sbjct: 17 SKYEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKGEATQFNRYKGSIYLVFDFCEHDLAGLLSNANVKFTLAEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQGNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKDPY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 318
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 254.603 bits (649), Expect = 9.020e-76 Identity = 135/303 (44.55%), Postives = 189/303 (62.38%), Query Frame = 3
Query: 1095 SAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLY--IADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKV-TRLPLFESYKPRHNYKRRLREH---YCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
S + + K+G+GT+G VFKA+ QTG+ ALKKV +ENEKEGFPITA+REIKIL L H N+VNL EI A F + KG+ YLVFD+ +HDL G+L + +V T ++ + + LL G+ Y H LHRD+K +N+L+ G +KLADFGLAR + + + YTN+V+TLWYRPPELLLGE Y P ID+W GCI+ E++T + + E Q+ IS++CG WP V + L++ + KR++++ Y P ALDL+D +L LDP +R + AL D+
Sbjct: 38 SKYEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR--TKATQFNRYKGSIYLVFDFCEHDLAGLLSNANVKFTLAEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQGNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKDPY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 337
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 254.603 bits (649), Expect = 9.020e-76 Identity = 135/303 (44.55%), Postives = 189/303 (62.38%), Query Frame = 3
Query: 1095 SAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLY--IADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKV-TRLPLFESYKPRHNYKRRLREH---YCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
S + + K+G+GT+G VFKA+ QTG+ ALKKV +ENEKEGFPITA+REIKIL L H N+VNL EI A F + KG+ YLVFD+ +HDL G+L + +V T ++ + + LL G+ Y H LHRD+K +N+L+ G +KLADFGLAR + + + YTN+V+TLWYRPPELLLGE Y P ID+W GCI+ E++T + + E Q+ IS++CG WP V + L++ + KR++++ Y P ALDL+D +L LDP +R + AL D+
Sbjct: 38 SKYEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR--TKATQFNRYKGSIYLVFDFCEHDLAGLLSNANVKFTLAEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQGNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKDPY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 337
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 474.937 bits (1221), Expect = 2.243e-152 Identity = 224/353 (63.46%), Postives = 274/353 (77.62%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
L K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P+ ALDLLD ML LDP KRCTA Q L+SD+L++VD K+ PD P +DCHEL SKKRR+
Sbjct: 405 LKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRR 756
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 474.552 bits (1220), Expect = 2.602e-150 Identity = 224/353 (63.46%), Postives = 274/353 (77.62%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
L K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P+ ALDLLD ML LDP KRCTA Q L+SD+L++VD K+ PD P +DCHEL SKKRR+
Sbjct: 681 LKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRR 1032
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 477.248 bits (1227), Expect = 3.701e-150 Identity = 224/353 (63.46%), Postives = 274/353 (77.62%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
L K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P+ ALDLLD ML LDP KRCTA Q L+SD+L++VD K+ PD P +DCHEL SKKRR+
Sbjct: 681 LKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRR 1032
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 476.863 bits (1226), Expect = 1.575e-149 Identity = 224/353 (63.46%), Postives = 274/353 (77.62%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
L K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P+ ALDLLD ML LDP KRCTA Q L+SD+L++VD K+ PD P +DCHEL SKKRR+
Sbjct: 681 LKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRR 1032
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 475.322 bits (1222), Expect = 1.055e-148 Identity = 224/353 (63.46%), Postives = 274/353 (77.62%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
L K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P+ ALDLLD ML LDP KRCTA Q L+SD+L++VD K+ PD P +DCHEL SKKRR+
Sbjct: 681 LKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRR 1032
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk13 (cyclin-dependent kinase 13 [Source:MGI Symbol;Acc:MGI:1916812]) HSP 1 Score: 468.003 bits (1203), Expect = 5.295e-151 Identity = 219/351 (62.39%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKRSAT--RNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDE-QVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R ++ WG+R V F I +GEGTYG V+KA D TGE+ ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDFKKDKGAFYLVF+YMDHDL G+LES V +E + S +QL+EG+ YCH +NFLHRDIKCSNIL+NNRG+IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+R+LRE + +P+ ALDL D+ML LDP KRCTA QAL+ ++LR+V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 64 RRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRR 413
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk12 (cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]) HSP 1 Score: 478.019 bits (1229), Expect = 2.196e-150 Identity = 225/351 (64.10%), Postives = 272/351 (77.49%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QLVH ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1045
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk12 (cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]) HSP 1 Score: 477.633 bits (1228), Expect = 1.502e-148 Identity = 225/351 (64.10%), Postives = 272/351 (77.49%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QLVH ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1045
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk12 (cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]) HSP 1 Score: 477.248 bits (1227), Expect = 2.916e-148 Identity = 225/351 (64.10%), Postives = 272/351 (77.49%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QLVH ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1045
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk13 (cyclin-dependent kinase 13 [Source:MGI Symbol;Acc:MGI:1916812]) HSP 1 Score: 472.241 bits (1214), Expect = 1.026e-146 Identity = 219/351 (62.39%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKRSA--TRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDE-QVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R ++ WG+R V F I +GEGTYG V+KA D TGE+ ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDFKKDKGAFYLVF+YMDHDL G+LES V +E + S +QL+EG+ YCH +NFLHRDIKCSNIL+NNRG+IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+R+LRE + +P+ ALDL D+ML LDP KRCTA QAL+ ++LR+V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 678 RRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRR 1027
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|B5DE93|CDK12_XENTR (Cyclin-dependent kinase 12 OS=Xenopus tropicalis OX=8364 GN=cdk12 PE=2 SV=1) HSP 1 Score: 476.093 bits (1224), Expect = 5.570e-149 Identity = 224/353 (63.46%), Postives = 274/353 (77.62%), Query Frame = 3
Query: 1020 LMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
L K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P+ ALDLLD ML LDP KRCTA Q L+SD+L++VD K+ PD P +DCHEL SKKRR+
Sbjct: 681 LKKRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHELWSKKRRR 1032
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|Q9NYV4|CDK12_HUMAN (Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2) HSP 1 Score: 478.789 bits (1231), Expect = 5.168e-148 Identity = 224/351 (63.82%), Postives = 273/351 (77.78%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG++YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 700 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1049
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|Q14AX6|CDK12_MOUSE (Cyclin-dependent kinase 12 OS=Mus musculus OX=10090 GN=Cdk12 PE=1 SV=2) HSP 1 Score: 477.248 bits (1227), Expect = 2.040e-147 Identity = 225/351 (64.10%), Postives = 272/351 (77.49%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QLVH ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1045
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|Q3MJK5|CDK12_RAT (Cyclin-dependent kinase 12 OS=Rattus norvegicus OX=10116 GN=Cdk12 PE=1 SV=1) HSP 1 Score: 476.863 bits (1226), Expect = 2.666e-147 Identity = 225/351 (64.10%), Postives = 272/351 (77.49%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QLVH ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR 1045
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|D2H526|CDK12_AILME (Cyclin-dependent kinase 12 OS=Ailuropoda melanoleuca OX=9646 GN=CDK12 PE=3 SV=1) HSP 1 Score: 476.093 bits (1224), Expect = 5.953e-147 Identity = 224/351 (63.82%), Postives = 272/351 (77.49%), Query Frame = 3
Query: 1026 KKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P IC R R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL+H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A+ E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +PS ALDLLD ML LDP KRCTA Q L+SD+L++V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 701 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMDPPDLPHWQDCHELWSKKRRR 1050
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A0X3PWT4 (Protein kinase domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR154445 PE=4 SV=1) HSP 1 Score: 560.066 bits (1442), Expect = 0.000e+0 Identity = 272/455 (59.78%), Postives = 339/455 (74.51%), Query Frame = 3
Query: 804 IPNNLPLPKIGSSVYENHINHKSEKSKNY-CKPT-------------LPLP-NIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDL 2120
+P+N P P+ G+ Y + H N PT LPLP +++ I RS ++ + KS + +++++P IC +RS TRNNVTWGERSV+AF +++VGEGTYGHV+KA D TGE KALKKVRLENE+EGFPITA+REIKIL QL H NIVNLCEIVTD D+A DFKKD+GAF+LVFDYMDHDL+G+LES V T+ VAS+ KQL+ G+ YCHSRNFLHRDIKCSNIL+NNRG++KLADFGLARLYIADDK+RPYTNKVITLWYRPPELLLGEE Y PA+DIWS GCILGELFT + MF A+EEMEQ+E I +VCG P+ WP V LP++ +++P+ YKRRLR++Y LP+ ALDLLD ML LDP KRC+A +AL WLRN+D I PP+ P ++ CHE+ SKKRRK+MR E+E+KA K+G+++
Sbjct: 202 LPSNPPKPQ-GTKRYRDSTPHLPSADPNLPSGPTSIKECSKRTTLVDLPLPPGFDASTMSDIARSQFPNTQASSNPRKSVR----STVLQRPKICEQRSKTRNNVTWGERSVTAFETLEQVGEGTYGHVYKARDRITGEFKALKKVRLENEREGFPITAVREIKILRQLRHENIVNLCEIVTDKDDATDFKKDRGAFFLVFDYMDHDLYGLLESGLVTFTEAHVASLMKQLMLGLHYCHSRNFLHRDIKCSNILINNRGQLKLADFGLARLYIADDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGELFTRKPMFAANEEMEQLEVICRVCGYPDNLTWPDVDHLPMYSTFRPKQLYKRRLRQNYKFLPTLALDLLDSMLYLDPRKRCSAREALDCPWLRNIDPTAIPPPNMPTNQHCHEMWSKKRRKVMRHEQEIKAQKLGIEM 651
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A0X3PU84 (Protein kinase domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR154445 PE=4 SV=1) HSP 1 Score: 560.066 bits (1442), Expect = 0.000e+0 Identity = 272/455 (59.78%), Postives = 339/455 (74.51%), Query Frame = 3
Query: 804 IPNNLPLPKIGSSVYENHINHKSEKSKNY-CKPT-------------LPLP-NIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDL 2120
+P+N P P+ G+ Y + H N PT LPLP +++ I RS ++ + KS + +++++P IC +RS TRNNVTWGERSV+AF +++VGEGTYGHV+KA D TGE KALKKVRLENE+EGFPITA+REIKIL QL H NIVNLCEIVTD D+A DFKKD+GAF+LVFDYMDHDL+G+LES V T+ VAS+ KQL+ G+ YCHSRNFLHRDIKCSNIL+NNRG++KLADFGLARLYIADDK+RPYTNKVITLWYRPPELLLGEE Y PA+DIWS GCILGELFT + MF A+EEMEQ+E I +VCG P+ WP V LP++ +++P+ YKRRLR++Y LP+ ALDLLD ML LDP KRC+A +AL WLRN+D I PP+ P ++ CHE+ SKKRRK+MR E+E+KA K+G+++
Sbjct: 206 LPSNPPKPQ-GTKRYRDSTPHLPSADPNLPSGPTSIKECSKRTTLVDLPLPPGFDASTMSDIARSQFPNTQASSNPRKSVR----STVLQRPKICEQRSKTRNNVTWGERSVTAFETLEQVGEGTYGHVYKARDRITGEFKALKKVRLENEREGFPITAVREIKILRQLRHENIVNLCEIVTDKDDATDFKKDRGAFFLVFDYMDHDLYGLLESGLVTFTEAHVASLMKQLMLGLHYCHSRNFLHRDIKCSNILINNRGQLKLADFGLARLYIADDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGELFTRKPMFAANEEMEQLEVICRVCGYPDNLTWPDVDHLPMYSTFRPKQLYKRRLRQNYKFLPTLALDLLDSMLYLDPRKRCSAREALDCPWLRNIDPTAIPPPNMPTNQHCHEMWSKKRRKVMRHEQEIKAQKLGIEM 655
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A183SXW5 (Protein kinase domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS9063 PE=4 SV=1) HSP 1 Score: 560.066 bits (1442), Expect = 0.000e+0 Identity = 272/455 (59.78%), Postives = 339/455 (74.51%), Query Frame = 3
Query: 804 IPNNLPLPKIGSSVYENHINHKSEKSKNY-CKPT-------------LPLP-NIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDL 2120
+P+N P P+ G+ Y + H N PT LPLP +++ I RS ++ + KS + +++++P IC +RS TRNNVTWGERSV+AF +++VGEGTYGHV+KA D TGE KALKKVRLENE+EGFPITA+REIKIL QL H NIVNLCEIVTD D+A DFKKD+GAF+LVFDYMDHDL+G+LES V T+ VAS+ KQL+ G+ YCHSRNFLHRDIKCSNIL+NNRG++KLADFGLARLYIADDK+RPYTNKVITLWYRPPELLLGEE Y PA+DIWS GCILGELFT + MF A+EEMEQ+E I +VCG P+ WP V LP++ +++P+ YKRRLR++Y LP+ ALDLLD ML LDP KRC+A +AL WLRN+D I PP+ P ++ CHE+ SKKRRK+MR E+E+KA K+G+++
Sbjct: 127 LPSNPPKPQ-GTKRYRDSTPHLPSADPNLPSGPTSIKECSKRTTLVDLPLPPGFDASTMSDIARSQFPNTQASSNPRKSVR----STVLQRPKICEQRSKTRNNVTWGERSVTAFETLEQVGEGTYGHVYKARDRITGEFKALKKVRLENEREGFPITAVREIKILRQLRHENIVNLCEIVTDKDDATDFKKDRGAFFLVFDYMDHDLYGLLESGLVTFTEAHVASLMKQLMLGLHYCHSRNFLHRDIKCSNILINNRGQLKLADFGLARLYIADDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGELFTRKPMFAANEEMEQLEVICRVCGYPDNLTWPDVDHLPMYSTFRPKQLYKRRLRQNYKFLPTLALDLLDSMLYLDPRKRCSAREALDCPWLRNIDPTAIPPPNMPTNQHCHEMWSKKRRKVMRHEQEIKAQKLGIEM 576
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A0X3P5G7 (Protein kinase domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR154445 PE=4 SV=1) HSP 1 Score: 559.681 bits (1441), Expect = 0.000e+0 Identity = 272/455 (59.78%), Postives = 339/455 (74.51%), Query Frame = 3
Query: 804 IPNNLPLPKIGSSVYENHINHKSEKSKNY-CKPT-------------LPLP-NIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDL 2120
+P+N P P+ G+ Y + H N PT LPLP +++ I RS ++ + KS + +++++P IC +RS TRNNVTWGERSV+AF +++VGEGTYGHV+KA D TGE KALKKVRLENE+EGFPITA+REIKIL QL H NIVNLCEIVTD D+A DFKKD+GAF+LVFDYMDHDL+G+LES V T+ VAS+ KQL+ G+ YCHSRNFLHRDIKCSNIL+NNRG++KLADFGLARLYIADDK+RPYTNKVITLWYRPPELLLGEE Y PA+DIWS GCILGELFT + MF A+EEMEQ+E I +VCG P+ WP V LP++ +++P+ YKRRLR++Y LP+ ALDLLD ML LDP KRC+A +AL WLRN+D I PP+ P ++ CHE+ SKKRRK+MR E+E+KA K+G+++
Sbjct: 210 LPSNPPKPQ-GTKRYRDSTPHLPSADPNLPSGPTSIKECSKRTTLVDLPLPPGFDASTMSDIARSQFPNTQASSNPRKSVR----STVLQRPKICEQRSKTRNNVTWGERSVTAFETLEQVGEGTYGHVYKARDRITGEFKALKKVRLENEREGFPITAVREIKILRQLRHENIVNLCEIVTDKDDATDFKKDRGAFFLVFDYMDHDLYGLLESGLVTFTEAHVASLMKQLMLGLHYCHSRNFLHRDIKCSNILINNRGQLKLADFGLARLYIADDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGELFTRKPMFAANEEMEQLEVICRVCGYPDNLTWPDVDHLPMYSTFRPKQLYKRRLRQNYKFLPTLALDLLDSMLYLDPRKRCSAREALDCPWLRNIDPTAIPPPNMPTNQHCHEMWSKKRRKVMRHEQEIKAQKLGIEM 659
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A0X3NHI9 (Protein kinase domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR154445 PE=4 SV=1) HSP 1 Score: 559.681 bits (1441), Expect = 0.000e+0 Identity = 272/455 (59.78%), Postives = 339/455 (74.51%), Query Frame = 3
Query: 804 IPNNLPLPKIGSSVYENHINHKSEKSKNY-CKPT-------------LPLP-NIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDL 2120
+P+N P P+ G+ Y + H N PT LPLP +++ I RS ++ + KS + +++++P IC +RS TRNNVTWGERSV+AF +++VGEGTYGHV+KA D TGE KALKKVRLENE+EGFPITA+REIKIL QL H NIVNLCEIVTD D+A DFKKD+GAF+LVFDYMDHDL+G+LES V T+ VAS+ KQL+ G+ YCHSRNFLHRDIKCSNIL+NNRG++KLADFGLARLYIADDK+RPYTNKVITLWYRPPELLLGEE Y PA+DIWS GCILGELFT + MF A+EEMEQ+E I +VCG P+ WP V LP++ +++P+ YKRRLR++Y LP+ ALDLLD ML LDP KRC+A +AL WLRN+D I PP+ P ++ CHE+ SKKRRK+MR E+E+KA K+G+++
Sbjct: 206 LPSNPPKPQ-GTKRYRDSTPHLPSADPNLPSGPTSIKECSKRTTLVDLPLPPGFDASTMSDIARSQFPNTQASSNPRKSVR----STVLQRPKICEQRSKTRNNVTWGERSVTAFETLEQVGEGTYGHVYKARDRITGEFKALKKVRLENEREGFPITAVREIKILRQLRHENIVNLCEIVTDKDDATDFKKDRGAFFLVFDYMDHDLYGLLESGLVTFTEAHVASLMKQLMLGLHYCHSRNFLHRDIKCSNILINNRGQLKLADFGLARLYIADDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGELFTRKPMFAANEEMEQLEVICRVCGYPDNLTWPDVDHLPMYSTFRPKQLYKRRLRQNYKFLPTLALDLLDSMLYLDPRKRCSAREALDCPWLRNIDPTAIPPPNMPTNQHCHEMWSKKRRKVMRHEQEIKAQKLGIEM 655
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk12 (cyclin dependent kinase 12 [Source:NCBI gene;Acc:103040863]) HSP 1 Score: 472.626 bits (1215), Expect = 4.813e-148 Identity = 224/351 (63.82%), Postives = 271/351 (77.21%), Query Frame = 3
Query: 1026 KKPGICAKRSATR--NNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P C+ R R + WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V + E + S +QL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE YSPAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + LP+ ALDLLD ML LDP +RCTA QAL+S +L +VD K+ PPD P +DCHEL SKKRR+
Sbjct: 647 KRPKFCSPRFGERRQTQIDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVSFSQEHIRSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFLPTPALDLLDRMLTLDPSRRCTAEQALESQFLCDVDPSKMSPPDLPHWQDCHELWSKKRRR 996
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk12 (cyclin dependent kinase 12 [Source:NCBI gene;Acc:103040863]) HSP 1 Score: 472.626 bits (1215), Expect = 5.539e-148 Identity = 224/351 (63.82%), Postives = 271/351 (77.21%), Query Frame = 3
Query: 1026 KKPGICAKRSATR--NNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
K+P C+ R R + WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V + E + S +QL+EG+ YCH +NFLHRDIKCSNIL+NN G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE YSPAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + LP+ ALDLLD ML LDP +RCTA QAL+S +L +VD K+ PPD P +DCHEL SKKRR+
Sbjct: 658 KRPKFCSPRFGERRQTQIDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVSFSQEHIRSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFLPTPALDLLDRMLTLDPSRRCTAEQALESQFLCDVDPSKMSPPDLPHWQDCHELWSKKRRR 1007
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk13 (cyclin dependent kinase 13 [Source:NCBI gene;Acc:103043281]) HSP 1 Score: 470.7 bits (1210), Expect = 2.401e-146 Identity = 222/362 (61.33%), Postives = 272/362 (75.14%), Query Frame = 3
Query: 1017 SLMKKPGICAKRSA--TRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKEL 2093
+L ++P IC R + WG+R V F + GEGTYG V+KA D T E+ ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDFK DKGAFYLVF+YMDHDL G+LES V + + S +QLLEG+ YCH +NFLHRDIKCSNIL+NN+G+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P ALDL D ML LDP KRCTA QAL SD+LR+VD K+ PPD P +DCHEL SKKRR+ + +EL
Sbjct: 609 TLRRRPKICGPRFGEIKETEIDWGKRCVDKFEILGITGEGTYGQVYKARDKDTAEMVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALDFKNDKGAFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFAFIPPTALDLFDHMLALDPSKRCTAEQALNSDFLRDVDPAKMPPPDLPLWQDCHELWSKKRRRQKQMPEEL 969
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 254.603 bits (649), Expect = 4.531e-75 Identity = 135/303 (44.55%), Postives = 189/303 (62.38%), Query Frame = 3
Query: 1095 SAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLY--IADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKV-TRLPLFESYKPRHNYKRRLREH---YCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
S + + K+G+GT+G VFKA+ QTG+ ALKKV +ENEKEGFPITA+REIKIL L H N+VNL EI A F + KG+ YLVFD+ +HDL G+L + +V T ++ + + LL G+ Y H LHRD+K +N+L+ G +KLADFGLAR + + + YTN+V+TLWYRPPELLLGE Y P ID+W GCI+ E++T + + E Q+ IS++CG WP V + L++ + KR++++ Y P ALDL+D +L LDP +R + AL D+
Sbjct: 102 SKYEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR--TKATQFNRYKGSIYLVFDFCEHDLAGLLSNANVKFTLAEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGILKLADFGLARAFSLAKNSQGNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGGGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITAEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKDPY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 401
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk10 (cyclin dependent kinase 10 [Source:NCBI gene;Acc:103043383]) HSP 1 Score: 249.595 bits (636), Expect = 1.799e-74 Identity = 127/320 (39.69%), Postives = 202/320 (63.12%), Query Frame = 3
Query: 1086 RSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILES-KSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRN--VDSKKIKPPDFPRDRD 2036
R+V F ++++GEGTYG V++A D +T E+ ALKKVR++ EK+G PI+++REI +L++L H NIV L E+V + + L+ + +LV Y + DL +LE+ +S ++ QV I QLL+G++Y H LHRD+K SN+L+ ++G +K+ADFGLAR+Y ++P T KV+TLWYR PELLLG + + A+D+W++GCIL EL + + + S E++Q++ I ++ G PN N WP +RLPL Y R L+ + L L LL+ + +P++R +A +L+S + + + + P FP R+
Sbjct: 31 RNVKEFEKLNRIGEGTYGIVYRARDTRTNEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVV--VGSHLE------SLFLVMSYCEQDLASLLENMQSPFSEAQVKCIVLQLLKGLEYLHHNFILHRDLKVSNLLMTDKGCVKIADFGLARVY--GVPQQPMTPKVVTLWYRAPELLLGTKTQTTALDMWAVGCILAELLAHKPLLSGSSEIQQLDLIVQLLGTPNENIWPGFSRLPLVGQYSLRKQPYNNLKNKFTWLSEAGLRLLNLLFMYNPQRRASAKDSLESSYFKEKPLPCEPELMPTFPHHRN 340
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000855.1 (pep scaffold:Pmarinus_7.0:GL480767:13986:34488:-1 gene:ENSPMAG00000000768.1 transcript:ENSPMAT00000000855.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 469.929 bits (1208), Expect = 1.094e-149 Identity = 224/351 (63.82%), Postives = 270/351 (76.92%), Query Frame = 3
Query: 1026 KKPGICAKRSA--TRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++A+DFKKDKGAFYLVFDYMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NNRG IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y PAID+WS GCILGELFT + +F A++EM Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + LP+ ALDL D L LDP KRCTA QAL+SD+LR++D K+ PPD P +DCHEL SKKRR+
Sbjct: 571 RRPKICGPRYGEIKGTEADWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSIINMKEIVTDKEDAIDFKKDKGAFYLVFDYMDHDLMGLLESGLVSFSEDHIKSFMKQLMEGLDYCHRKNFLHRDIKCSNILLNNRGHIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTRKPIFQANQEMAQLELISRLCGTPCPAVWPDVIKLPYFHTMKPKKQYRRRLREEFSMLPTAALDLFD-HLALDPSKRCTAEQALQSDFLRDIDPYKMPPPDLPLWQDCHELWSKKRRR 919
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000851.1 (pep scaffold:Pmarinus_7.0:GL480767:12807:33146:-1 gene:ENSPMAG00000000768.1 transcript:ENSPMAT00000000851.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 471.47 bits (1212), Expect = 1.342e-148 Identity = 225/351 (64.10%), Postives = 271/351 (77.21%), Query Frame = 3
Query: 1026 KKPGICAKRSA--TRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++A+DFKKDKGAFYLVFDYMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NNRG IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y PAID+WS GCILGELFT + +F A++EM Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + LP+ ALDL D ML LDP KRCTA QAL+SD+LR++D K+ PPD P +DCHEL SKKRR+
Sbjct: 529 RRPKICGPRYGEIKGTEADWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSIINMKEIVTDKEDAIDFKKDKGAFYLVFDYMDHDLMGLLESGLVSFSEDHIKSFMKQLMEGLDYCHRKNFLHRDIKCSNILLNNRGHIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTRKPIFQANQEMAQLELISRLCGTPCPAVWPDVIKLPYFHTMKPKKQYRRRLREEFSMLPTAALDLFD-MLALDPSKRCTAEQALQSDFLRDIDPYKMPPPDLPLWQDCHELWSKKRRR 877
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000850.1 (pep scaffold:Pmarinus_7.0:GL480767:12801:33146:-1 gene:ENSPMAG00000000768.1 transcript:ENSPMAT00000000850.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 471.47 bits (1212), Expect = 1.759e-148 Identity = 225/351 (64.10%), Postives = 271/351 (77.21%), Query Frame = 3
Query: 1026 KKPGICAKRSA--TRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++P IC R WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++A+DFKKDKGAFYLVFDYMDHDL G+LES V +++ + S KQL+EG+ YCH +NFLHRDIKCSNIL+NNRG IKLADFGLARLY + ++ RPYTNKVITLWYRPPELLLGEE Y PAID+WS GCILGELFT + +F A++EM Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + LP+ ALDL D ML LDP KRCTA QAL+SD+LR++D K+ PPD P +DCHEL SKKRR+
Sbjct: 528 RRPKICGPRYGEIKGTEADWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSIINMKEIVTDKEDAIDFKKDKGAFYLVFDYMDHDLMGLLESGLVSFSEDHIKSFMKQLMEGLDYCHRKNFLHRDIKCSNILLNNRGHIKLADFGLARLY-SSEESRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTRKPIFQANQEMAQLELISRLCGTPCPAVWPDVIKLPYFHTMKPKKQYRRRLREEFSMLPTAALDLFD-MLALDPSKRCTAEQALQSDFLRDIDPYKMPPPDLPLWQDCHELWSKKRRR 876
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741]) HSP 1 Score: 239.965 bits (611), Expect = 1.782e-72 Identity = 134/306 (43.79%), Postives = 186/306 (60.78%), Query Frame = 3
Query: 1101 FRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILE--SKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKP 2012
F+ ++K+GEGTYG V+KA + TGE ALKK+RL+ E EG P TAIREI +L +L H NIV L I+ + YLVF+ +D DL ++ + S I V S QLL+GI +CHS LHRD+K N+L+N G IKLADFGLAR + +R YT++V+TLWYR PE+LLG + YS ++D+WS+GCI E+ T + +F E++Q+ I + G P+ WP V++LP ++S PR + L + TL DLL ML+ DP +R TA AL + +NV K+I P
Sbjct: 4 FQKVEKIGEGTYGVVYKARNKLTGEAVALKKIRLDTETEGVPSTAIREISLLRELNHPNIVRLLTII----------HSEKKLYLVFELLDQDLKKFMDNATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAEGAIKLADFGLARAF--GVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVSQLPDYKSTFPRWA-NQELTKVVPTLNFEGRDLLALMLQYDPNQRVTANMALSHCFFQNV--KQIVP 294
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741]) HSP 1 Score: 228.409 bits (581), Expect = 3.168e-68 Identity = 124/300 (41.33%), Postives = 181/300 (60.33%), Query Frame = 3
Query: 1101 FRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKS--VITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVD 1994
F+ ++K+GEGTYG V+KA TG+ ALKK+RL+ E EG P TAIREI +L +L H NIV L +++ + YLVF+++D DL +++ I+ V S QLL+GI +CH++ LHRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR PE+LLG + YS A+D+WSLGCI E+ T + +F E++Q+ I + G P+ W +T+LP ++ PR + L + L + DLL ML+ DP +R +A AL + N++
Sbjct: 4 FQKVEKIGEGTYGVVYKARHKMTGDTVALKKIRLDTETEGVPSTAIREIALLRELNHPNIVRLLDVI----------HSETKLYLVFEFLDQDLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADGAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDETVWQGITQLPDYKPSFPRWC-AQDLTKVVPLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHNLE 290
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: CTK1 (Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 [Source:SGD;Acc:S000001622]) HSP 1 Score: 268.47 bits (685), Expect = 2.866e-80 Identity = 146/337 (43.32%), Postives = 203/337 (60.24%), Query Frame = 3
Query: 1083 ERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHN--YKRRLREHY-CTLP-SRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMR 2078
+RS S + I +VGEGTYG V+KA++ T +L ALKK+RL+ E+EGFPIT+IREIK+L H N+ + EI+ + + Y++F+Y D+DL G+L +K V I+ Q +FKQLL G++Y H LHRD+K SNIL++N+G +K+ DFGLAR + + YTN+VITLWYRPPELLLG Y +D+W GC+L ELF +F S E+EQ+ESI K+ G P +N WP + +P F P+ Y E + LP S+ L L +L D KR +AT+AL+SD+ + + K +P CHE K RK R
Sbjct: 177 QRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVE---------SQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLAR---KMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFK--EEPKPEPLVLDGLVSCHEYEVKLARKQKR 499
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: CDC28 (Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant [Source:SGD;Acc:S000000364]) HSP 1 Score: 219.164 bits (557), Expect = 5.329e-65 Identity = 122/297 (41.08%), Postives = 177/297 (59.60%), Query Frame = 3
Query: 1092 VSAFRFIDKVGEGTYGHVFKAEDIQTGE---LKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILES---KSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQA 1964
++ ++ ++KVGEGTYG V+KA D++ G+ + ALKK+RLE+E EG P TAIREI +L +L NIV L +IV D YLVF+++D DL +E + + V QL +GI YCHS LHRD+K N+L+N G +KL DFGLAR + R YT++++TLWYR PE+LLG + YS +D WS+GCI E+ + +F+ E++Q+ I +V G PN WP + LP F+ P+ ++ L + +L R +DLLD +L DP R +A +A
Sbjct: 5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIV---------HSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGV--PLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWR-RKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRA 289
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 217.624 bits (553), Expect = 1.793e-64 Identity = 120/308 (38.96%), Postives = 187/308 (60.71%), Query Frame = 3
Query: 1089 SVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQ-----VASIFK-QLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFE---SYKPRHNYKRRLREHYCT-LPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
S S F+ ++K+G GTY V+K + TG ALK+V+L++E EG P TAIREI ++ +L H NIV L +++ +N L LVF++MD+DL ++S++V + + F+ QLL+G+ +CH LHRD+K N+L+N RG++KL DFGLAR + ++++V+TLWYR P++L+G YS +IDIWS GCIL E+ TG+ +F + + EQ++ I + G PN + WP VT+LP + +P + ++ L+ H L +D L +L+L+P+ R +A QAL W
Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENIVRLYDVI-HTENKLT---------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: SGV1 (Cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation; phosphorylates the carboxy-terminal domain (CTD) of Rpo21p and the C-terminal repeat domain of Spt5p; recruits Spt6p to the CTD at the onset of transcription; regulated by Cak1p; similar to metazoan CDK9 proteins [Source:SGD;Acc:S000006365]) HSP 1 Score: 223.016 bits (567), Expect = 1.022e-62 Identity = 133/345 (38.55%), Postives = 191/345 (55.36%), Query Frame = 3
Query: 1101 FRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIV----TDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDE-QVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIA--DDKKRP--------YTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCT-LPSRALDLLDWMLRLDPEKRCTATQALKSDWLRN--VDSKKIKPPDFPRDRDCHELSSKKRRKLMRQ 2081
+R +K+G+GT+G V+K ++T A+KK+ + EK+ FPITA REI IL +L H NI+ L E+V DI NA K +FY++ YM DL G+L + + + + ++ Q+LEG+ Y H F+HRDIK +NIL+++ G +KLADFGLARLY + K P YT+ V+T WYR PEL+LG++ Y+ A+DIW +GC+ E F + + +++Q I K+ G P DW LP E NYK LRE + L LD L +L LDP KR TA A W + + S+KI P + HE K+ ++ M Q
Sbjct: 60 YREDEKLGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPITAQREITILKRLNHKNIIKLIEMVYDHSPDITNAASSNLHK-SFYMILPYMVADLSGVLHNPRINLEMCDIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYPGGAGSGAKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKKPILQGKTDIDQGHVIFKLLGTPTEEDWAVARYLPGAELTTT--NYKPTLRERFGKYLSETGLDFLGQLLALDPYKRLTAMSAKHHPWFKEDPLPSEKITLP----TEESHEADIKRYKEEMHQ 397
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: KIN28 (Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002266]) HSP 1 Score: 186.037 bits (471), Expect = 4.708e-53 Identity = 109/308 (35.39%), Postives = 165/308 (53.57%), Query Frame = 3
Query: 1116 KVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVI-TDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNY----KRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFP 2024
KVGEGTY V+ TG A+K+++ K+G ++AIRE+K L ++ H N++ L +I DN LV +++ DL +++ KS++ T + + L G+ +CH LHRD+K +N+L + G+IK+ADFGLAR A + T+ V+T WYR PELL G + Y+ AIDIWS+G I EL +++QME + G P DWP+V+ F +Y Y + LR+ + ALD + ML ++P+KR TA Q L+SD+ K++ PP P
Sbjct: 12 KVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDN----------LNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEI--LTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSS---FMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYF-----KELPPPSDP 299
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO46173 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQW1]) HSP 1 Score: 400.593 bits (1028), Expect = 7.876e-133 Identity = 194/295 (65.76%), Postives = 233/295 (78.98%), Query Frame = 3
Query: 1101 FRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
F I+++GEGTYG V+KA+D TGEL LKKVR +NEKEGFPITA+REIKIL QL H NI+NL EIVTD NALDF+KDKGAFYLVF+YMDHDL G+LES V +T++ + S +QLL+G+ YCH +NFLHRDIKCSNIL+NN+GEIKLADFGLARLY AD++ RPYTNKVITLWYRPPELLLGEE Y P IDIWS+GCIL ELFT + +F A +E+ Q+E IS+VCG P WP + LP F S KP+ Y+RR+RE + LP ALDL D ML LDP +R TA +AL+ +L
Sbjct: 2 FDIIEQIGEGTYGQVYKAKDKITGELVGLKKVRTDNEKEGFPITAVREIKILCQLNHPNIINLKEIVTDKPNALDFRKDKGAFYLVFEYMDHDLMGLLESGLVHLTEDHIKSFIRQLLDGLNYCHKKNFLHRDIKCSNILLNNKGEIKLADFGLARLYEADER-RPYTNKVITLWYRPPELLLGEERYGPGIDIWSVGCILAELFTKKPIFPAYQEIGQLELISRVCGTPTPAVWPSIINLPHFHSIKPKRQYRRRIREEFNFLPEDALDLFDAMLTLDPSQRITAEKALEHPFL 295
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO28453 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T6F2]) HSP 1 Score: 350.903 bits (899), Expect = 4.287e-114 Identity = 176/287 (61.32%), Postives = 215/287 (74.91%), Query Frame = 3
Query: 1170 GELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPR 2027
GEL LKKVR +NEKEGFPITA+REIKIL QL H NI+NL EIVTD NALDF+KDKGAFYLVF+YMDHDL G+LES V +T++ + S +QLL+G+ YCH +NFLHRDIKCSNIL+NN+GEIKLADFGLARLY AD+ +RPYTNKVITLWYRPPELLLGEE Y P IDIWS LGE+ + + ++ +E+ S+ +VCG P WP + LP F S KP+ Y+RR+RE + LP ALDL D ML LDP +R TA +AL+ +L +V+ I PP + R
Sbjct: 1 GELVGLKKVRTDNEKEGFPITAVREIKILCQLNHPNIINLKEIVTDKPNALDFRKDKGAFYLVFEYMDHDLMGLLESGLVHLTEDHIKSFIRQLLDGLNYCHKKNFLHRDIKCSNILLNNKGEIKLADFGLARLYEADE-RRPYTNKVITLWYRPPELLLGEERYGPGIDIWS---CLGEM-SSAIIVSSGDELSHY-SVYRVCGTPTPAVWPSIINLPHFHSIKPKRQYRRRIREEFNFLPEDALDLFDAMLTLDPSQRITAEKALEHPFLTDVNPHNIIPPRYSR 281
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO34765 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNE8]) HSP 1 Score: 253.062 bits (645), Expect = 5.408e-76 Identity = 136/302 (45.03%), Postives = 189/302 (62.58%), Query Frame = 3
Query: 1092 VSAFRFIDKVGEGTYGHVFKAEDIQT-GELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLAR-LYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLRE--HYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
VS + K+G+GT+G VFKA++ + E+ ALKKV ++NEKEGFPITA+REIKIL L H N+V L EI A F ++K + YLVF++ +HDL G+L +++V + ++ I + LL + + HS LHRD+K +NIL+ G +KLA+FGLAR ++I ++K+ YTN+V+TLWYRPPELLLGE Y P ID+W GCI+ EL+T + + E Q+ IS +CG WP V +L LF+ KRR++E ALDL+D ML LDP R A AL D+
Sbjct: 14 VSKYERQAKIGQGTFGEVFKAKNRKNPKEIVALKKVLMDNEKEGFPITALREIKILQLLNHENVVKLLEICRT--KAQPFNRNKASIYLVFEFCEHDLAGLLNNQAVKFSPPEMKKIMQMLLNALYFIHSNKILHRDMKAANILITKNGVLKLAEFGLARAIHINKEQKQRYTNRVVTLWYRPPELLLGERNYGPPIDLWGAGCIMAELWTRTPIMQGNTEQHQLTLISHLCGSITPEVWPGVDKLELFDKMVLPSGQKRRVKERLRMYVKDHNALDLIDKMLSLDPGPRIDADSALNHDYF 313
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO29995 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T226]) HSP 1 Score: 243.047 bits (619), Expect = 2.626e-72 Identity = 130/347 (37.46%), Postives = 204/347 (58.79%), Query Frame = 3
Query: 1086 RSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRN----VDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMG 2111
R V+ F ++++GEGTYG V++A+D ++G++ ALKKVR+E E++G PI+ +REI +L+ L H NIV L E+V + LD + +L +Y + D+ +L++ S ++ Q+ + QLLEG +Y H +HRD+K SN+L+ +G +K+ADFGLAR + +P T V+TLWYR PELLLG + ++ A+D+W++GCI GEL + + E+ Q++ I + G PN + WP + LP +S +H L+ + + L LL++ML DP KR TA ++L+S + VD+ + P FP R+ K R EK+ KAH G
Sbjct: 31 RPVAEFEKLNRIGEGTYGIVYRAKDTKSGKIVALKKVRMEQERDGIPISGLREITLLLNLRHENIVQLLEVV--VGKHLD------SLFLSMEYCEQDIASLLDNMSCPFSEAQIKCLMIQLLEGTKYLHEHFIVHRDLKVSNLLLTGKGVLKIADFGLARTF--GYPYKPMTPVVVTLWYRSPELLLGAKVHTTAVDMWAVGCIFGELLGNKPLLAGKSEINQLQLIVDLLGTPNDHIWPGYSSLPGVKSISLKHQPYNNLKHKFSWVSQAGLSLLNYMLMYDPCKRATAAESLQSSYFVEKPLPVDADMM--PTFPEHRNF-----KNRSPTEGVEKKDKAHSRG 360
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO41403 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4F0]) HSP 1 Score: 235.728 bits (600), Expect = 1.147e-70 Identity = 123/302 (40.73%), Postives = 182/302 (60.26%), Query Frame = 3
Query: 1101 FRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILES--KSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSK 2000
F ++K+GEGTYG V+KA D TG + ALKK+RL+ E EG P TAIREI +L +L H N+V+L ++V ++ + YLVF+++ DL ++ S I+ + S QLL G+ YCHS LHRD+K N+L++ G IKLADFGLAR + R YT++V+TLWYR PE+LLG Y+ +D+WS+GCI E+ T + +F E++Q+ I + G P+ WP V+ LP +++ P+ + +R TL + A+DLL ML P R +A AL ++ ++V K
Sbjct: 4 FEKVEKIGEGTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVV----------HNQKSLYLVFEFLSQDLKKYMDCLPPSGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAIKLADFGLARAF--GVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVSELPDYKTSFPKWPVQ-SIRHVLPTLDNTAIDLLQKMLTYQPNARISAKAALSHEFFKDVQRK 292
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:101169207]) HSP 1 Score: 479.174 bits (1232), Expect = 4.164e-150 Identity = 229/355 (64.51%), Postives = 275/355 (77.46%), Query Frame = 3
Query: 1014 VSLMKKPGICAKRSATR--NNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRK 2069
++L K+P IC R R N WG+R V F I +GEGTYG V+KA+D TGEL ALKKVRL+NEKEGFPITAIREIKIL QL H ++VN+ EIVTD +ALDFKKDKGAFYLVF+YMDHDL G+LES V + E V S +QL+EG+ YCH NFLHRDIKCSNIL+NNRG+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE YSPAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LPLF + KP+ Y+RRLRE + LP+ ALDLLD ML LDP +RCT+ QAL SD+L +V+ K+ PPD P +DCHEL SKKRR+
Sbjct: 672 MTLKKRPKICCPRYGERKHNLSDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLKHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSHEHVRSFMRQLMEGLDYCHKNNFLHRDIKCSNILLNNRGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAVWPDVIKLPLFNTMKPKKQYRRRLREEFAFLPTPALDLLDRMLTLDPARRCTSEQALTSDFLCDVEPSKMPPPDLPHHQDCHELWSKKRRR 1025
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk13 (cyclin dependent kinase 13 [Source:NCBI gene;Acc:101169150]) HSP 1 Score: 470.315 bits (1209), Expect = 1.712e-146 Identity = 226/383 (59.01%), Postives = 282/383 (73.63%), Query Frame = 3
Query: 999 QLSSDVSLMKKPGICAKRSATRNNVT--WGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHK-----MGVDLS 2123
+L + ++P IC R + WG+R V F I GEGTYG V+KA+D TGE+ ALKKVRL+NEKEGFPITAIREIKIL QL H +I+N+ EIVTD ++ALDF+ DKGAFYLVF+YMDHDL G+LES V + + S +QLLEG+ YCH +NFLHRDIKCSNIL+NNRG+IKLADFGLARLY +++ RPYTNKVITLWYRPPELLLGEE Y+PAID+WS GCILGELFT + +F A++E+ Q+E IS++CG P WP V +LP F + KP+ Y+RRLRE + +P ALDL D ML LDP +RCTA QAL S++L++VD K+ PPD P +DCHEL SKKRR+ + +EL A K +G+D S
Sbjct: 600 KLEKSQTFRRRPKICGPRFGEIKEIEIDWGKRCVDKFEIIGITGEGTYGQVYKAKDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALDFRNDKGAFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYNSEES-RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPFFNTMKPKKQYRRRLREEFAFIPPAALDLFDHMLNLDPGRRCTAEQALSSEFLKDVDPDKMPPPDLPLWQDCHELWSKKRRRQKQMPEELVAPKAPRKELGLDDS 981
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk9 (cyclin dependent kinase 9 [Source:NCBI gene;Acc:101158180]) HSP 1 Score: 253.062 bits (645), Expect = 2.747e-75 Identity = 132/302 (43.71%), Postives = 187/302 (61.92%), Query Frame = 3
Query: 1095 SAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLY--IADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKV-TRLPLFESYKPRHNYKRRLREHYCTL--PSRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
S + + K+G+GT+G VFKA+ TG+ ALKKV +ENEKEGFPITA+REIKIL L H N+VNL EI A F + KG+ YLVFD+ +HDL G+L + +V T ++ + + LL G+ Y H LHRD+K +N+L+ G +KLADFGLAR + + + YTN+V+TLWYRPPELLLGE Y P ID+W GCI+ E++T + + E Q+ IS++CG WP V + L++ + KR++++ + ALDL+D +L LDP +R + AL D+
Sbjct: 38 SKYEKMAKIGQGTFGEVFKAKHRTTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRT--KATQFNRYKGSIYLVFDFCEHDLAGLLSNANVKFTLAEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQGNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITAEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKDAYALDLIDKLLVLDPAQRIDSDDALNHDFF 337
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk2 (cyclin dependent kinase 2 [Source:NCBI gene;Acc:101161880]) HSP 1 Score: 239.58 bits (610), Expect = 1.512e-71 Identity = 131/302 (43.38%), Postives = 187/302 (61.92%), Query Frame = 3
Query: 1092 VSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV--ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNV 1991
+ F+ ++K+GEGTYG V+KA++ TGE ALKK+RL+ E EG P TAIREI +L +L H NIV L +++ +N L YLVF+++ DL ++S SV I V S QLL+G+ +CHS LHRD+K N+L+N +GEIKLADFGLAR + R YT++V+TLWYR PE+LLG + YS A+D+WSLGCI E+ T + +F E++Q+ I + G P+ WP VT +P ++ P+ ++ L + L +LL ML+ DP KR +A AL + R+V
Sbjct: 1 MDTFQKVEKIGEGTYGVVYKAKNKLTGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNIVKLQDVI-HTENKL---------YLVFEFLHQDLKKFMDSSSVTGIPLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGV--PVRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDETAWPGVTSMPDYKPSFPKWA-RQDLSKVVPLLDEDGRELLGEMLKYDPNKRLSAKNALVHRFFRDV 289
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk10 (cyclin dependent kinase 10 [Source:NCBI gene;Acc:101169200]) HSP 1 Score: 231.876 bits (590), Expect = 5.051e-68 Identity = 120/320 (37.50%), Postives = 196/320 (61.25%), Query Frame = 3
Query: 1086 RSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILES-KSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRN--VDSKKIKPPDFPRDRD 2036
RSV F ++++GEGTYG V++A D ++ E+ ALKKVR++ EK+G PI+++REI +L++L H NIV L E+V + + L+ + +LV Y + DL +LE+ ++ ++ QV I QLL+G++Y H +HRD+K SN+L+ ++G +K+ADFGLAR+Y + T +V+TLWYR PE+LLG + + A+D+W++GCIL EL + + + E++Q++ I ++ G PN N WP ++LPL Y R L+ + L LL+ + +P +R TA L+S + + + + P FP R+
Sbjct: 35 RSVREFEKLNRIGEGTYGIVYRARDTRSNEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVV--VGSQLE------SLFLVMSYCEQDLASLLENMQTPFSETQVKCIVLQLLKGLEYLHHNFIIHRDLKVSNLLMTDKGYVKIADFGLARMY--GIPQPLMTPRVVTLWYRAPEVLLGTKIQTTALDMWAVGCILAELLAHKPLLPGTSEIQQVDLIVQLLGTPNENIWPGFSQLPLIGQYSLRKQPYNNLKNKFTWLSDAGHRLLNLLFMYNPLRRATAKDCLESSYFKEKPLPCEPELMPTFPHHRN 344
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000057162.1 (SMESG000057162.1) HSP 1 Score: 1367.44 bits (3538), Expect = 0.000e+0 Identity = 889/889 (100.00%), Postives = 889/889 (100.00%), Query Frame = 3
Query: 21 MNSKRKMCEPYDSESESTEKIXXXXXXXXXXXXDYSLSPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXINSNYKEDSTKFDSYPSEFMDKFKKQSGIMSELQKINCSNSLLSEIQKKFQXXXXXXXXXXXXXXXXATPNKSEKVITDTPPDEIKDEPNAELFDNMNIKLEDINLXXXXXXXXXXXXXXXXXXLNEXXXXXXXXXXXXXXXLIXXXXXXXXXXXXXXXXXXXXXXXXAVFGNTEFTKLSTIPNNLPLPKIGSSVYENHINHKSEKSKNYCKPTLPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDLSGEVKSSRTSSKITDXXXXXXXXXXXXXXXXXXXXXXXXXXKFDEXXXXXXXXXXXLINGDANDISEALSKLIPNAKDLIKNILEQLPKGTQFDPVKLNEALLPFVNXXXXXXXXXXXXXXXXXXXXXXXXXXXXDDNAKIDTGCNGPKKQSQPACISFDYNHGDNLLLPPDEKCLRQADQAIIRNQWR 2687
MNSKRKMCEPYDSESESTEKIRKSRKSHHRSSSDYSLSPKRVKLEKKLKKSKKHKSSKSHKYKHSHSAKSRSRSASKRKKINSNYKEDSTKFDSYPSEFMDKFKKQSGIMSELQKINCSNSLLSEIQKKFQKSENSNSSEKSTPTPSATPNKSEKVITDTPPDEIKDEPNAELFDNMNIKLEDINLPPEPEKPKKIIEEVKAEILNEPPPPPPLTPEMVPPPLIELEKPETESELSTLLPTKEETKTKAVFGNTEFTKLSTIPNNLPLPKIGSSVYENHINHKSEKSKNYCKPTLPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDLSGEVKSSRTSSKITDNNSKSHNSSSVPVSVGIGNNNNSSRNKFDEKSDKSDSYYDKLINGDANDISEALSKLIPNAKDLIKNILEQLPKGTQFDPVKLNEALLPFVNQINNASSSTSLSSSNSKPQQQQQQHVSNDDNAKIDTGCNGPKKQSQPACISFDYNHGDNLLLPPDEKCLRQADQAIIRNQWR
Sbjct: 1 MNSKRKMCEPYDSESESTEKIRKSRKSHHRSSSDYSLSPKRVKLEKKLKKSKKHKSSKSHKYKHSHSAKSRSRSASKRKKINSNYKEDSTKFDSYPSEFMDKFKKQSGIMSELQKINCSNSLLSEIQKKFQKSENSNSSEKSTPTPSATPNKSEKVITDTPPDEIKDEPNAELFDNMNIKLEDINLPPEPEKPKKIIEEVKAEILNEPPPPPPLTPEMVPPPLIELEKPETESELSTLLPTKEETKTKAVFGNTEFTKLSTIPNNLPLPKIGSSVYENHINHKSEKSKNYCKPTLPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDLSGEVKSSRTSSKITDNNSKSHNSSSVPVSVGIGNNNNSSRNKFDEKSDKSDSYYDKLINGDANDISEALSKLIPNAKDLIKNILEQLPKGTQFDPVKLNEALLPFVNQINNASSSTSLSSSNSKPQQQQQQHVSNDDNAKIDTGCNGPKKQSQPACISFDYNHGDNLLLPPDEKCLRQADQAIIRNQWR 889
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000057162.1 (SMESG000057162.1) HSP 1 Score: 1355.89 bits (3508), Expect = 0.000e+0 Identity = 883/883 (100.00%), Postives = 883/883 (100.00%), Query Frame = 3
Query: 39 MCEPYDSESESTEKIXXXXXXXXXXXXDYSLSPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXINSNYKEDSTKFDSYPSEFMDKFKKQSGIMSELQKINCSNSLLSEIQKKFQXXXXXXXXXXXXXXXXATPNKSEKVITDTPPDEIKDEPNAELFDNMNIKLEDINLXXXXXXXXXXXXXXXXXXLNEXXXXXXXXXXXXXXXLIXXXXXXXXXXXXXXXXXXXXXXXXAVFGNTEFTKLSTIPNNLPLPKIGSSVYENHINHKSEKSKNYCKPTLPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDLSGEVKSSRTSSKITDXXXXXXXXXXXXXXXXXXXXXXXXXXKFDEXXXXXXXXXXXLINGDANDISEALSKLIPNAKDLIKNILEQLPKGTQFDPVKLNEALLPFVNXXXXXXXXXXXXXXXXXXXXXXXXXXXXDDNAKIDTGCNGPKKQSQPACISFDYNHGDNLLLPPDEKCLRQADQAIIRNQWR 2687
MCEPYDSESESTEKIRKSRKSHHRSSSDYSLSPKRVKLEKKLKKSKKHKSSKSHKYKHSHSAKSRSRSASKRKKINSNYKEDSTKFDSYPSEFMDKFKKQSGIMSELQKINCSNSLLSEIQKKFQKSENSNSSEKSTPTPSATPNKSEKVITDTPPDEIKDEPNAELFDNMNIKLEDINLPPEPEKPKKIIEEVKAEILNEPPPPPPLTPEMVPPPLIELEKPETESELSTLLPTKEETKTKAVFGNTEFTKLSTIPNNLPLPKIGSSVYENHINHKSEKSKNYCKPTLPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDLSGEVKSSRTSSKITDNNSKSHNSSSVPVSVGIGNNNNSSRNKFDEKSDKSDSYYDKLINGDANDISEALSKLIPNAKDLIKNILEQLPKGTQFDPVKLNEALLPFVNQINNASSSTSLSSSNSKPQQQQQQHVSNDDNAKIDTGCNGPKKQSQPACISFDYNHGDNLLLPPDEKCLRQADQAIIRNQWR
Sbjct: 1 MCEPYDSESESTEKIRKSRKSHHRSSSDYSLSPKRVKLEKKLKKSKKHKSSKSHKYKHSHSAKSRSRSASKRKKINSNYKEDSTKFDSYPSEFMDKFKKQSGIMSELQKINCSNSLLSEIQKKFQKSENSNSSEKSTPTPSATPNKSEKVITDTPPDEIKDEPNAELFDNMNIKLEDINLPPEPEKPKKIIEEVKAEILNEPPPPPPLTPEMVPPPLIELEKPETESELSTLLPTKEETKTKAVFGNTEFTKLSTIPNNLPLPKIGSSVYENHINHKSEKSKNYCKPTLPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHKMGVDLSGEVKSSRTSSKITDNNSKSHNSSSVPVSVGIGNNNNSSRNKFDEKSDKSDSYYDKLINGDANDISEALSKLIPNAKDLIKNILEQLPKGTQFDPVKLNEALLPFVNQINNASSSTSLSSSNSKPQQQQQQHVSNDDNAKIDTGCNGPKKQSQPACISFDYNHGDNLLLPPDEKCLRQADQAIIRNQWR 883
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000078149.1 (SMESG000078149.1) HSP 1 Score: 488.804 bits (1257), Expect = 8.655e-162 Identity = 237/401 (59.10%), Postives = 295/401 (73.57%), Query Frame = 3
Query: 903 LPLPNIPTKSVNSIFRSSKSESKIDKSLSKSHQLSSDVSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHELSSKKRRKLMRQEKELKAHK 2105
LPLP +P S N+ ++ K E +I + K P IC RS +N ERSV +F+ I +VGEGTYGHVFKA D QT +KALKK+RLENE+EGFPIT +REIKIL +L H NI+ L E+VTD D+ + K KG FYLVF+YMDHDL+GIL+S + + Q+ASI KQ++ GI YCH R FLHRDIK SNILVNN+GE+K+ADFGLAR + AD+ KRPYTNKVITLWYR PELLLGEE Y AID+WS+GCI+GELF +TMFTAS EM+Q+E+ISKVCG PN WP VT+LPLF +++P+ NYKRRLRE+YCTLP AL++LDWML+LDP++RC+ QAL S WLR +D K+I PP FP D+D HELS K+R + + K+ K
Sbjct: 117 LPLPVVP--SNNTHVKNDKKEKEI---------------IFKMPKICESRSRIKNT----ERSVKSFKIIAEVGEGTYGHVFKAIDRQTNAMKALKKIRLENEREGFPITTVREIKILHKLNHPNIIYLNEVVTDYDSKSN-SKVKG-FYLVFEYMDHDLYGILDSGITLNENQIASIMKQIISGICYCHKRKFLHRDIKSSNILVNNKGEVKIADFGLARKFEADNSKRPYTNKVITLWYRAPELLLGEEIYGEAIDVWSIGCIMGELFVRRTMFTASNEMDQLETISKVCGTPNAGIWPNVTKLPLFATFRPKCNYKRRLREYYCTLPHSALEVLDWMLQLDPKRRCSTEQALNSYWLRKIDPKQIPPPAFPADKDYHELSCKRRHRQNHSDTGYKSSK 494
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000055046.1 (SMESG000055046.1) HSP 1 Score: 235.728 bits (600), Expect = 4.758e-68 Identity = 132/323 (40.87%), Postives = 194/323 (60.06%), Query Frame = 3
Query: 1080 GERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILES-KSVITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIADDKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESY------KPRHNYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPR 2027
G R +S + F++K+ EGTYG VF+A+D +T E+ ALK++++ENEK GFPIT++RE+ LM+ H NIV + E+V + N LD + YLV D+++HDL +++ +V + QLLE I + H +HRD+K SN+L+++ G +K+ADFGLAR Y + K YTN V+TLWYR PELLLG++ YS ID+WS+GCI GEL + +F EMEQ++ + + GVP WP V+ LP+ + KPR+ ++RL L + + +L PEKR TA +A K + I P FP+
Sbjct: 156 GCRFLSNYEFLNKIEEGTYGEVFRAKDKKTKEIVALKRLKMENEKYGFPITSLREVNTLMKAQHENIVTVREVV--VGNDLD------SIYLVMDFVEHDLKSLMKIINRAFEISEVKCLMLQLLEAIAHLHDNWIIHRDLKTSNLLLSHNGILKVADFGLAREYGSPLKS--YTNLVVTLWYRAPELLLGQKMYSTNIDMWSVGCIFGELLLNRALFAGKSEMEQIQILFRELGVPTEETWPGVSELPMMKKVNFKLKEKPRN--EKRLSNR---LSLGGKYVFNKLLTFCPEKRFTAEEAKKHYYFSET-PLPIHPQQFPK 462
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000028783.1 (SMESG000028783.1) HSP 1 Score: 232.261 bits (591), Expect = 6.356e-68 Identity = 134/305 (43.93%), Postives = 187/305 (61.31%), Query Frame = 3
Query: 1086 RSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDKGAFYLVFDYMDHDLFGILESKSV-ITDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIAD---DKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEEMEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRHNYKRRLREHYCTLP--SRALDLLDWMLRLDPEKRCTATQALKSDWL 1982
+ V + + K+G+GT+G VFK DIQT + ALK+++LE EKEGFPITA+REIKIL L H NIV L EI + K K FYL+FD DHDL G+L +++ + Q SI KQL GI Y H N +HRD+K +NIL+ G +K+ADFGLAR I D YT++V+T+WYRPPE+LL + Y ++D+W GCI+ EL+T + E+ Q++ I +CG N WP V++L F+ + R N+KR +R+ + A+DL+D +L LDP KR TA AL ++
Sbjct: 36 KHVDQYEKLQKIGQGTFGEVFKVRDIQTKKYYALKRIKLEQEKEGFPITALREIKILQSLNHPNIVCLREICC--SSPTKEKLYKPEFYLLFDLCDHDLAGLLSDQNMKFSLPQRKSIMKQLFTGIFYLHRNNVIHRDLKAANILIEKHGTLKIADFGLARYTIKSPKPDHPPKYTSRVVTMWYRPPEILLNDRHYDKSVDMWGAGCIMAELWTKYPIMQGESEIHQLKLIINLCGSINEESWPGVSKLEAFKRLE-RTNHKRFVRQQLLKVIDCHSAVDLIDKLLLLDPRKRLTADIALMHEFF 337 The following BLAST results are available for this feature:
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002908 ID=SMED30002908|Name=Cyclin-dependent kinase 12|organism=Schmidtea mediterranea sexual|type=transcript|length=2808bpback to top protein sequence of SMED30002908-orf-1 >SMED30002908-orf-1 ID=SMED30002908-orf-1|Name=SMED30002908-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=915bp MNSKRKMCEPYDSESESTEKIRKSRKSHHRSSSDYSLSPKRVKLEKKLKKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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