Acid sphingomyelinase-like phosphodiesterase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002811 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416]) HSP 1 Score: 177.178 bits (448), Expect = 7.914e-49 Identity = 123/423 (29.08%), Postives = 199/423 (47.04%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327 G FWHI D+HL+ + ++ D +G+Y DS +AL SS+ MK PDFI+ GD++ H + D +L + + +T +R FP T + ++GNHD +P N S+ N + W+ P +SN I FKKG FY + + I+VLN L+Y N+ +DP QF WL+ L A + V++V HV PG E K F FN+++LK+++ + VI FF H HTD+F+++Y+ P+ +F++P VTP+ G V NP++R++ ++ T + Y +L N T W+LEY + P+ SA S+ + + Y + + C E +C + +C +R +D + +CL Sbjct: 21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWK---PWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQG---TPRWELEYQLTEAYGVPDASAHSM---HTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDE--ACSMQHVCAMRQVDIDAYTTCL 429
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416]) HSP 1 Score: 167.162 bits (422), Expect = 7.214e-46 Identity = 101/314 (32.17%), Postives = 160/314 (50.96%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN 1009 G FWHI D+HL+ + ++ D +G+Y DS +AL SS+ MK PDFI+ GD++ H + D +L + + +T +R FP T + ++GNHD +P N S+ N + W+ P +SN I FKKG FY + + I+VLN L+Y N+ +DP QF WL+ L A + V++V HV PG E K F FN+++LK+++ + VI FF H HTD+F+++Y+ P+ +F++P VTP+ G V NP++R++ ++ Sbjct: 21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWK---PWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYD 328
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3A (sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol;Acc:HGNC:17389]) HSP 1 Score: 155.606 bits (392), Expect = 4.937e-41 Identity = 120/421 (28.50%), Postives = 206/421 (48.93%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDE-TCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G FWH+ D+HL+ ++ + D + +G+ DS + L S+ F+K+S F+I GD+ H + + + I +N+T ++ FP + P++GNHD P + + V +S N W+ P + I T +KG FY+ + T N II LN L+Y N +DP NQF WL++ L ++ + KV+++AHV G S+ +N++ + + Q Y+DVI F+ H H D+ ++ + PV LF++P+VTP ++ + + NP +RL+ ++ QY+ +L N+ +S+ WKLEY+ + +L +SL G +F++ S F +++Y +D TC +T C+ IC I N+D S CL + Sbjct: 38 GQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWK---PWLDEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQ-NITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESI---WKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVS--YDSSVTCDKT--CKAFQICAIMNLDNISYADCLKQ 446
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416]) HSP 1 Score: 132.88 bits (333), Expect = 3.317e-33 Identity = 107/417 (25.66%), Postives = 175/417 (41.97%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327 G FWHI D+HL+ + ++ D +G+Y DS +AL SS+ MK PDFI+ GD++ H + D +L + A+L + + K V P G FY + + I+VLN L+Y N+ +DP QF WL+ L A + V++V HV PG E K F FN+++LK+++ + VI FF H HTD+F+++Y+ P+ +F++P VTP+ G V NP++R++ ++ T + Y +L N T W+LEY + P+ SA S+ + + Y + + C E +C + +C +R +D + +CL Sbjct: 21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEA---------------AVLEIV------------------ERLTKLIREVFP------------GAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQG---TPRWELEYQLTEAYGVPDASAHSM---HTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDE--ACSMQHVCAMRQVDIDAYTTCL 381
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3A (sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol;Acc:HGNC:17389]) HSP 1 Score: 130.183 bits (326), Expect = 5.040e-33 Identity = 98/331 (29.61%), Postives = 165/331 (49.85%), Query Frame = 2 Query: 371 VTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDE-TCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345 +T ++ FP + P++GNHD P + + V +S N W+ P + I T +KG FY+ + T N II LN L+Y N +DP NQF WL++ L ++ + KV+++AHV G S+ +N++ + + Q Y+DVI F+ H H D+ ++ + PV LF++P+VTP ++ + + NP +RL+ ++ QY+ +L N+ +S+ WKLEY+ + +L +SL G +F++ S F +++Y +D TC +T C+ IC I N+D S CL + K Sbjct: 1 MTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWK---PWLDEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQ-NITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESI---WKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVS--YDSSVTCDKT--CKAFQICAIMNLDNISYADCLKQLYIK 319
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186012:10190157:-1 gene:WBGene00014106.1 transcript:ZK856.5.3 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5) HSP 1 Score: 124.02 bits (310), Expect = 2.591e-30 Identity = 96/311 (30.87%), Postives = 145/311 (46.62%), Query Frame = 2 Query: 158 HICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRL-HFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVN-SYVK-TNS-DPLNQFMWLKTKLQLARASMMK--------VFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF--NLWQLGSVNPSVRLY 1000 H+ D HL+ + +N N+ YG+Y D+ L Q ++ + PD II GDN H +++ N T L FP ILP+ GNHD P+N SS ++ W+ L + + TF KG +Y + + + +VLN L+Y N +YV TN DP +QF +L+ +L A + V +VAH+ PG E P F F ++N+RFL L YA+ I F H HTD F ++ +S V ++P+VTP+ +L G+ NP+ R+Y Sbjct: 25 HLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESESSLYTKTWELWKGKL---GDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFEKTP-NFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVY 327
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186023:10190366:-1 gene:WBGene00014106.1 transcript:ZK856.5.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5) HSP 1 Score: 124.02 bits (310), Expect = 2.591e-30 Identity = 96/311 (30.87%), Postives = 145/311 (46.62%), Query Frame = 2 Query: 158 HICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRL-HFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVN-SYVK-TNS-DPLNQFMWLKTKLQLARASMMK--------VFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF--NLWQLGSVNPSVRLY 1000 H+ D HL+ + +N N+ YG+Y D+ L Q ++ + PD II GDN H +++ N T L FP ILP+ GNHD P+N SS ++ W+ L + + TF KG +Y + + + +VLN L+Y N +YV TN DP +QF +L+ +L A + V +VAH+ PG E P F F ++N+RFL L YA+ I F H HTD F ++ +S V ++P+VTP+ +L G+ NP+ R+Y Sbjct: 25 HLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESESSLYTKTWELWKGKL---GDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFEKTP-NFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVY 327
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186023:10190131:-1 gene:WBGene00014106.1 transcript:ZK856.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5) HSP 1 Score: 124.02 bits (310), Expect = 2.591e-30 Identity = 96/311 (30.87%), Postives = 145/311 (46.62%), Query Frame = 2 Query: 158 HICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRL-HFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVN-SYVK-TNS-DPLNQFMWLKTKLQLARASMMK--------VFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF--NLWQLGSVNPSVRLY 1000 H+ D HL+ + +N N+ YG+Y D+ L Q ++ + PD II GDN H +++ N T L FP ILP+ GNHD P+N SS ++ W+ L + + TF KG +Y + + + +VLN L+Y N +YV TN DP +QF +L+ +L A + V +VAH+ PG E P F F ++N+RFL L YA+ I F H HTD F ++ +S V ++P+VTP+ +L G+ NP+ R+Y Sbjct: 25 HLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESESSLYTKTWELWKGKL---GDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFEKTP-NFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVY 327
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: asm-3 (Putative sphingomyelin phosphodiesterase asm-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9UAY4]) HSP 1 Score: 75.8702 bits (185), Expect = 3.096e-14 Identity = 90/404 (22.28%), Postives = 167/404 (41.34%), Query Frame = 2 Query: 230 DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS---ISNVTGELRLHFPATAILPSMGNHDINPANFIS-------VNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXY--HLSGQPHDDETCPETSSCRCRFICGIRNIDYTS-----LDSCLTKCASKERKY 1357 D+ + L + + + S+ D+I+V+GD H + Y + N++ +R +FP T + ++GNH+ P + I+ + W + W+ +P +E GC+ D +I LN + ++N ++ N +DP WL +LQ A KV +VAH+ E+ N++ K+I YA+ + FF H H++ F ++Y + ++ P ++ +PSVTP++ + P+ R+Y +G GS Y ++ +L + N N +V +W++ Y S + L + + + Y H +D CR ++C R T L+ + K K+ KY Sbjct: 145 DTPYWLLTNMLQNIASTAGKLDYIMVSGDLVSH-TVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEY--NGCYMKKIYDGLR----MISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYY--------KIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDY-----FPAYRIYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNV--KWEVLYQSANMEYGLKGQIPTEYNQMIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQTQQLCTDLEGGIQKPEPKKNKY 526
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: asm-3 (Putative sphingomyelin phosphodiesterase asm-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9UAY4]) HSP 1 Score: 75.485 bits (184), Expect = 4.154e-14 Identity = 90/404 (22.28%), Postives = 167/404 (41.34%), Query Frame = 2 Query: 230 DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS---ISNVTGELRLHFPATAILPSMGNHDINPANFIS-------VNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXY--HLSGQPHDDETCPETSSCRCRFICGIRNIDYTS-----LDSCLTKCASKERKY 1357 D+ + L + + + S+ D+I+V+GD H + Y + N++ +R +FP T + ++GNH+ P + I+ + W + W+ +P +E GC+ D +I LN + ++N ++ N +DP WL +LQ A KV +VAH+ E+ N++ K+I YA+ + FF H H++ F ++Y + ++ P ++ +PSVTP++ + P+ R+Y +G GS Y ++ +L + N N +V +W++ Y S + L + + + Y H +D CR ++C R T L+ + K K+ KY Sbjct: 189 DTPYWLLTNMLQNIASTAGKLDYIMVSGDLVSH-TVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEY--NGCYMKKIYDGLR----MISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYY--------KIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDY-----FPAYRIYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNV--KWEVLYQSANMEYGLKGQIPTEYNQMIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQTQQLCTDLEGGIQKPEPKKNKY 570
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0347598) HSP 1 Score: 119.013 bits (297), Expect = 3.026e-28 Identity = 119/493 (24.14%), Postives = 199/493 (40.37%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSF-ILNDINR------------------------YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGK--IQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDP---------------------------------LNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN---FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEY--VSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSG--QPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK--CASKERK------YDWAWLAVPIVLF 1393 G FWHI D+HL+ + DI R +G+Y DS + L +S+V MK+ +F++ GD H + + + + + N+T L F + I P +G+ D S + + W LP+ + + TF +G +Y SI+ S+ I+ LN ++++ + DP Q++WL+ L ++ V++V H+ PG E + HN F + NQR+L +++ +A VI FF H H+D F+++Y++ P+ L ++PS+ P S NP++RLY ++ G+ Y Q+ LP N ++ W+ EY P +SA +L + F YH + + H CP C C I +DY CL K A + R W+WL + +F Sbjct: 26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGSYRRLGELWRHWLPSEA---LVTFDQGGYY--SIEQTKSRLRIVALN-------TNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPT---WQPEYNLTHYYALPEISAVALHN---FAERFTGTDLSWFTRYHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVF 489
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0347599) HSP 1 Score: 119.013 bits (297), Expect = 3.026e-28 Identity = 119/493 (24.14%), Postives = 199/493 (40.37%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSF-ILNDINR------------------------YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGK--IQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDP---------------------------------LNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN---FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEY--VSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSG--QPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK--CASKERK------YDWAWLAVPIVLF 1393 G FWHI D+HL+ + DI R +G+Y DS + L +S+V MK+ +F++ GD H + + + + + N+T L F + I P +G+ D S + + W LP+ + + TF +G +Y SI+ S+ I+ LN ++++ + DP Q++WL+ L ++ V++V H+ PG E + HN F + NQR+L +++ +A VI FF H H+D F+++Y++ P+ L ++PS+ P S NP++RLY ++ G+ Y Q+ LP N ++ W+ EY P +SA +L + F YH + + H CP C C I +DY CL K A + R W+WL + +F Sbjct: 26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGSYRRLGELWRHWLPSEA---LVTFDQGGYY--SIEQTKSRLRIVALN-------TNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPT---WQPEYNLTHYYALPEISAVALHN---FAERFTGTDLSWFTRYHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVF 489
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0332818) HSP 1 Score: 119.013 bits (297), Expect = 3.026e-28 Identity = 119/493 (24.14%), Postives = 199/493 (40.37%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSF-ILNDINR------------------------YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGK--IQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDP---------------------------------LNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN---FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEY--VSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSG--QPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK--CASKERK------YDWAWLAVPIVLF 1393 G FWHI D+HL+ + DI R +G+Y DS + L +S+V MK+ +F++ GD H + + + + + N+T L F + I P +G+ D S + + W LP+ + + TF +G +Y SI+ S+ I+ LN ++++ + DP Q++WL+ L ++ V++V H+ PG E + HN F + NQR+L +++ +A VI FF H H+D F+++Y++ P+ L ++PS+ P S NP++RLY ++ G+ Y Q+ LP N ++ W+ EY P +SA +L + F YH + + H CP C C I +DY CL K A + R W+WL + +F Sbjct: 26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGSYRRLGELWRHWLPSEA---LVTFDQGGYY--SIEQTKSRLRIVALN-------TNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPT---WQPEYNLTHYYALPEISAVALHN---FAERFTGTDLSWFTRYHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVF 489
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG3376 (gene:FBgn0034997 transcript:FBtr0072265) HSP 1 Score: 82.0333 bits (201), Expect = 5.843e-16 Identity = 73/285 (25.61%), Postives = 125/285 (43.86%), Query Frame = 2 Query: 206 NRYGNYKD-DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANF--------ISVNSSWCQNFYKF-WESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG 1012 ++G+Y+ D+ + + ++ D+I+ GD H + ++ L A I + ++ FP I P++GNH+ P N + ++ SW + W LP S T ++G FY+ + II LN N ++ NS DP + W +LQ A S KV ++ H+ PG ++ V NF+ K+I Y + A F+ H H D F++ Y+ + N P ++ PSV+P+ +NP R+Y +G Sbjct: 313 GKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENL-AIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQ---SVTHTVRRGAFYSVLV---RPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFY--------KIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYY-----DLNPGYRIYYVDG 577
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG3376 (gene:FBgn0034997 transcript:FBtr0072266) HSP 1 Score: 81.6481 bits (200), Expect = 6.286e-16 Identity = 73/285 (25.61%), Postives = 125/285 (43.86%), Query Frame = 2 Query: 206 NRYGNYKD-DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANF--------ISVNSSWCQNFYKF-WESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG 1012 ++G+Y+ D+ + + ++ D+I+ GD H + ++ L A I + ++ FP I P++GNH+ P N + ++ SW + W LP S T ++G FY+ + II LN N ++ NS DP + W +LQ A S KV ++ H+ PG ++ V NF+ K+I Y + A F+ H H D F++ Y+ + N P ++ PSV+P+ +NP R+Y +G Sbjct: 313 GKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENL-AIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQ---SVTHTVRRGAFYSVLV---RPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFY--------KIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYY-----DLNPGYRIYYVDG 577
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:ZFIN;Acc:ZDB-GENE-041008-132]) HSP 1 Score: 180.644 bits (457), Expect = 2.781e-50 Identity = 130/427 (30.44%), Postives = 201/427 (47.07%), Query Frame = 2 Query: 140 FQGTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFIS-VNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G FWHI D+H + S+ L+ RYG+Y DS ++L SS+ M+ PDFI+ GD++ H + D QL I N+T ++ FP T + +MGNHD +P N + S+ + W L S ETFK G +YT + + + +IVLN L+Y N + DP +QF W LQ A + KV+L+ HV PG E K F +FN+R+++LIQ ++ VI FF H HTD+F++ YNS P+ ++L+P VTP+ G + NP +R++ ++ + + Y+ +L NI W+ EY F P+ S S+ SS + L+ +D C + CR +C +R +DY + + C+ K Sbjct: 21 LTGYFWHISDLHWDPSYDLSSSSQSKCASSGGRPTPHAGRYGDYVCDSPWSLINSSLTAMREILPDPDFIMWTGDDTPH--VPDDQLGEQAVLRIIGNLTNIIKSTFPKTKVYSAMGNHDYHPKNQMPPAKSTIYEQTANLWRDWLHTASQ---ETFKTGGYYTEKLLNQTGLR-VIVLNTNLYYDQNKLTEKVKDPADQFSWADKVLQDAAKNNEKVYLIGHVPPGLFEKKRDKGW-FRKEFNKRYIELIQKHSAVIMGQFFGHHHTDSFRMFYNSKGSPISAMYLTPGVTPWITTLPGVIDGGNNPGIRIFEYDTKTLLVKDIITYYLNLTYANI----ARARWEKEYRLTEAFRVPDASPASM---HRVMERISSEKCSLQKYFELNSVSYDLSEC--HADCRVDHVCALREVDYDAYEKCVLK 431
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:ZFIN;Acc:ZDB-GENE-050327-61]) HSP 1 Score: 146.362 bits (368), Expect = 5.104e-38 Identity = 100/350 (28.57%), Postives = 175/350 (50.00%), Query Frame = 2 Query: 152 FWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPAN-FISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGA---AESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126 FWHI D+HL+ ++ + D +G++ DS + L S+ +MK P+FII GD+ H ++ + I +N+T ++ FP + P++GNHD P + F + ++ K W P ++ + + T +KG FY+ I ++ LN L+Y N SDP QF WL+ L+L+R SM KV+++AHV G A++ N +N++ +K+ ++Y++V++ F+ H H D+ ++ + +PV +F++P+VTP + + S NP VR Y++ S Q++ +L N+ +S WKLEY+ F Sbjct: 36 FWHISDLHLDPTYHVTEDHTKVCFSSKGVPALDPGVFGDFLCDSPYQLILSAFSYMKQVDLQPEFIIWTGDSPPHVPKEELSTDVVINVIANMTRTIQQFFPQIPVYPALGNHDYWPQDQFPTSENAIYDAVAKLWS---PWLNPAAVATLQKGGFYSLVI---KPGLRLLSLNTNLYYSPNEVTVNMSDPAGQFQWLQETLELSRQSMEKVYVIAHVPIGYLPFAKNTTAMREN----YNEQLVKIFRNYSEVVEGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSQIEPFSNNPGVRAYLYQPDSYTLLDIWQFYLNLTEANLEQRS---GWKLEYIMTEAF 372
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:ZFIN;Acc:ZDB-GENE-050327-61]) HSP 1 Score: 90.5077 bits (223), Expect = 2.377e-20 Identity = 52/162 (32.10%), Postives = 91/162 (56.17%), Query Frame = 2 Query: 656 SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGA---AESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126 SDP QF WL+ L+L+R SM KV+++AHV G A++ N+ N++ +K+ ++Y++V++ F+ H H D+ ++ + +PV +F++P+VTP + + S NP VR Y++ S Q++ +L N+ +S WKLEY+ F Sbjct: 3 SDPAGQFQWLQETLELSRQSMEKVYVIAHVPIGYLPFAKNTTAMRENY----NEQLVKIFRNYSEVVEGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSQIEPFSNNPGVRAYLYQPDSYTLLDIWQFYLNLTEANLEQRS---GWKLEYIMTEAF 157
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc:ZDB-GENE-110411-222]) HSP 1 Score: 79.337 bits (194), Expect = 5.052e-15 Identity = 67/255 (26.27%), Postives = 116/255 (45.49%), Query Frame = 2 Query: 293 DFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPA-TAILPSMGNHDINPAN-----FISVN--SSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG 1012 D++ GD H + ++ QLN ++ ++ + H + P++GNH+ P N F+ N S W + K W LP + +ET ++G FY+ ++ ++ LN + N ++ NS DP +Q WL LQ + KV ++ H+ PG S+ ++ + ++ Y I FF H HTD F++ Y+ P+ F++PSVT F ++NP R+Y +G Sbjct: 322 DWVYWTGDIPAHNVWSQTRNQQLNELVT-ISRLIHKHLGRNVTVYPAVGNHESTPVNSFPPPFVHGNHSSRWLYETMAKEWAPWLPEEA---LETIRRGGFYSVEVE---PGLRLVSLNMNFCSRENYWLMVNSTDPADQLQWLIQILQESENKGEKVHIIGHIPPGFCLSS----------WSWNYYHIVNRYESTITGQFFGHTHTDEFQMFYDEETLTRPLSVAFIAPSVTTFV-----NLNPGYRVYYVDG 554
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: ak9 (adenylate kinase 9 [Source:Xenbase;Acc:XB-GENE-994660]) HSP 1 Score: 179.874 bits (455), Expect = 6.208e-50 Identity = 130/449 (28.95%), Postives = 216/449 (48.11%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSF----------------ILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISV-NSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLW----QLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKER---KYDWAWLAVPIVLFLF 1399 G FWH+ D+HL+ ++ ++ D ++GNY DS L SS+ MKS PDFI+ GD++ H + + QL I +T ++ FP T + ++GNHD +P + + N+S +FW P + N + +F+KG +Y+ + + +IVLN L+Y NS DP +QF WL+ +L A KV++V HV PG E K F +FN+R++++IQ + VI FF H HTD+F++ Y+ + PV +F++P VTP+ + G+ NP +R+ ++ + Y+ +L N V+ W+ EY + P+ SA+S+ S+ S Y + +D E C +T CR +C IR +D+ C+ +S R + ++ +P+ F F Sbjct: 21 GYFWHLTDLHLDPNYSVTSDPRKVCPSAGDQLVPDAGQWGNYLCDSPRILINSSINAMKSILPNPDFILWTGDDTPH--VPNEQLGEDAVLEIIRWLTNLIQQTFPTTKVYSALGNHDFHPKSQLPPHNNSIYDRISEFWS---PWLKNESLPSFRKGAYYSEELKDVGAAGRMIVLNTNLYYDSNSLTANMKDPGDQFQWLEDQLNNANLKGEKVYIVGHVPPGYFEKKRDKPW-FREEFNKRYIEIIQKHHRVIQGQFFGHHHTDSFRMFYSDSGTPVSSMFIAPGVTPWKTTLPGVENGANNPGIRVVEYDRQNLQDIV-TYYLNLTYAN----KVSPRWEKEYRLTEAYQIPDCSAQSM---HDVVKKISNDSCYLQKYYKYNSVSYDLEACNKT--CRVDHVCAIREVDFNKYKECVKTESSSIRHMFELTVLFIVMPVYFFTF 453
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: smpdl3a (sphingomyelin phosphodiesterase acid-like 3A [Source:NCBI gene;Acc:595006]) HSP 1 Score: 164.851 bits (416), Expect = 2.324e-44 Identity = 128/437 (29.29%), Postives = 210/437 (48.05%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSF-ILNDINR---------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQ--MIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQ----FNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERK 1354 G FWHI D+HL+ S+ I D + +G++ DS + L S++ ++K S+ DF+I GD+ H +++ I N+T +R P + P++GNHD P + + V S +FW+ P ++ + TF+KG +Y+ + S II LN L+Y N +DP NQF WL+ L+++R + KV+++AHV G + F P FN+R +K+ ++Y+DVI A F+ H H D+ ++ + +PV +F++P+VTP + + S NP RLY ++ T YH Y +L N+ ++S W LEY+ + +L +SL+G V F S F ++ +L D C+ + IC I+ +D S C+ SKE K Sbjct: 34 GQFWHISDLHLDFSYHITEDRTKVCLSSKGAKASNPGIFGDFVCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTSTIRSLLPDLLVFPALGNHDYWPQDQLPVKESEVYTAVAEFWK---PWLTEEALSTFRKGGYYSQIYKSNKSAHSLRIISLNTNLYYTPNKVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGY-----LPFARLTPAMRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFVTPAVTPIRSALETDSNNPGFRLYQYDTTD----YHLLDLWHYFLNLTEANLKNES---SWNLEYIMTKTYQIKDLQPESLEGLVKRFQQPESIEFLYYYKNYLVSF---DSRVGCDPLCKLQQICAIQYVDEESYTKCI--IGSKEFK 450
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: smpdl3a (sphingomyelin phosphodiesterase acid-like 3A [Source:NCBI gene;Acc:595006]) HSP 1 Score: 162.155 bits (409), Expect = 1.242e-43 Identity = 127/434 (29.26%), Postives = 208/434 (47.93%), Query Frame = 2 Query: 152 FWHICDIHLNNSF-ILNDINR---------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQ--MIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGA---AESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERK 1354 FWHI D+HL+ S+ I D + +G++ DS + L S++ ++K S+ DF+I GD+ H +++ I N+T +R P + P++GNHD P + + V S +FW+ P ++ + TF+KG +Y+ + S II LN L+Y N +DP NQF WL+ L+++R + KV+++AHV G A P FN+R +K+ ++Y+DVI A F+ H H D+ ++ + +PV +F++P+VTP + + S NP RLY ++ T YH Y +L N+ ++S W LEY+ + +L +SL+G V F S F ++ +L D C+ + IC I+ +D S C+ SKE K Sbjct: 12 FWHISDLHLDFSYHITEDRTKVCLSSKGAKASNPGIFGDFVCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTSTIRSLLPDLLVFPALGNHDYWPQDQLPVKESEVYTAVAEFWK---PWLTEEALSTFRKGGYYSQIYKSNKSAHSLRIISLNTNLYYTPNKVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGYLPFARLTPA----MRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFVTPAVTPIRSALETDSNNPGFRLYQYDTTD----YHLLDLWHYFLNLTEANLKNES---SWNLEYIMTKTYQIKDLQPESLEGLVKRFQQPESIEFLYYYKNYLVSF---DSRVGCDPLCKLQQICAIQYVDEESYTKCI--IGSKEFK 426
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: SMPD1 (sphingomyelin phosphodiesterase 1 [Source:NCBI gene;Acc:100487433]) HSP 1 Score: 84.3445 bits (207), Expect = 1.257e-16 Identity = 87/342 (25.44%), Postives = 140/342 (40.94%), Query Frame = 2 Query: 347 QLNASISNVTGELRLHFPATAILPSMGNHDINPANFI-------SVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSR-----YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSC 1324 QL+A + +TG +R + A + P++GNH+ P N +++S W + + W LP S + T + FYT I + ++ LN N ++ N +DP Q WL LQ A KV ++ H+ PG + ++ + +++ Y I A FF H H D F++ Y+ PV F+SPSVT F ++NP R+Y +G S + Y +L N W L Y + + SA D + F Y L + H DE C E +C+ +C +R+ + + C Sbjct: 179 QLDA-LRTLTGLIRKYLGAVPVYPAVGNHESTPVNSFPPPYVQGNLSSHWLYHSMAQEWHHWLPQ---SALSTLRTAGFYTVPI---GPRLRLVSLNMNFCDLGNFWLLINYTDPAGQLQWLVEVLQEAEEKGEKVHIIGHIPPGLCLKS----------WSWNYYRIVNRYESTIAAQFFGHTHLDEFEMFYDEETLTRPVSVAFISPSVTTFI-----NLNPGYRVYQIDGEYPESSHMVLDHETYILNLTEANARPGQ-DPRWTLLYRALETYGMKSAFPADWELLTRRFLQDERLFQTFWY-LHHKGHVDEVCQE--NCKTTLLCALRSGRSSDPELC 494
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpdl3b (sphingomyelin phosphodiesterase, acid-like 3B [Source:MGI Symbol;Acc:MGI:1916022]) HSP 1 Score: 168.318 bits (425), Expect = 9.980e-46 Identity = 119/427 (27.87%), Postives = 199/427 (46.60%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345 G FWHI D+HL+ ++ ++ + +G+Y DS +AL SS+ MK PDFI+ GD++ H + + + A + +T ++ FP T + ++GNHD +P N S+ N + W P +SN FK+G FY+ + + ++VLN L+Y N +DP QF WL L A V+++ HV PG E K F FN+ +LK+IQ + VI FF H HTD+F++ Y++ P+ +FL+P VTP+ G V NP +R++ ++ + + Y +L N+ T W+ EY + P+ S S+ + + +S Y + ++ TC + SCR +C I+++ + + +CL +K Sbjct: 21 GRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWR---PWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAW-FRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQE---TPRWEQEYRLTEAYQVPDASVSSMH---TALTRIASEPHILQRYYVYNSVSYNHLTCED--SCRIEHVCAIQHVAFNTYATCLHGLGAK 435
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpdl3a (sphingomyelin phosphodiesterase, acid-like 3A [Source:MGI Symbol;Acc:MGI:1931437]) HSP 1 Score: 146.747 bits (369), Expect = 4.984e-38 Identity = 119/424 (28.07%), Postives = 197/424 (46.46%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFIS-VNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVS----PGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G FWH+ D+HL+ ++ + D +G+ DS + L S+ F+K+S F+I GD+ H + + I +N+T ++ FP + P++GNHD P + + V S W+ P + I T KKG FY+ + N II LN L+Y N +DP NQF WL+ L + + KV+++AHV P A ++ ++ + +N++ L + + Y+ VI F+ H H D+ ++ + N P+ +F++P+VTP + Q + NP VRL+ + G QY+ +L N+ +S W LEYV + +L KSL V +F+ S F ++ Y+ TC + C+ +C I N+D S D CL + Sbjct: 35 GQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWK---PWLGEEAISTLKKGGFYSQKV-ASNPGLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQY-----YNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYKPGDYTLLDMVQYYLNLTEANLKGES---NWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSY-DSSATCDQ--HCKTLQVCAIMNLDSMSYDDCLKQ 443
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpd1 (sphingomyelin phosphodiesterase 1, acid lysosomal [Source:MGI Symbol;Acc:MGI:98325]) HSP 1 Score: 84.7297 bits (208), Expect = 1.023e-16 Identity = 78/295 (26.44%), Postives = 125/295 (42.37%), Query Frame = 2 Query: 293 DFIIVNGDNSYHGKIQDYQLNA--SISNVTGELRLHFPATAILPSMGNHDINPAN-----FISVNSS--WC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRY----HQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126 + + GD H Q + + +++ +T +R + P++GNH+ P N FI N S W + K WE LP + + T + G FY T +I LN + N ++ NS DP Q WL +LQ A KV ++ H+ PG + ++ + K+I Y + + FF H H D F+I Y+ + P+ FL+PS T F ++NP R+Y +G GS + H+ + L N+ T WK Y + + Sbjct: 269 EMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADA---LHTLRIGGFYAL---TPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKS----------WSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFI-----NLNPGYRVYQIDGNYPGSSHVVLDHETYI-LNLTQANAAGGTPSWKRLYRARETY 541
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q54SR8|SGMC_DICDI (Sphingomyelinase phosphodiesterase C OS=Dictyostelium discoideum OX=44689 GN=sgmC PE=3 SV=1) HSP 1 Score: 182.57 bits (462), Expect = 3.173e-50 Identity = 134/371 (36.12%), Postives = 190/371 (51.21%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFI-------------------LNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNA-----SISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNN------EPVIPLFLSPSVTPFNLWQLGSV--NPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFP--NLSAKSL 1150 G FWHI D H + +I + GNYK D++F L QSS +M PDFII GD+ H + + QLN SI+N+T ++ +FP I PS+GNHD P + I V +W +N + W P +SN IETFK G +YT + + II LN + +Y N +DP Q +WL L A + +V+++ HV PG E V NFH QFN +L Y+D+I+ + H+HTD F++ Y+ N EP +FLSPS+TP+ L ++ NP +RLY +N TS A Y+Q+ T+L T NI S + I+W+LEY + F NLS S+ Sbjct: 32 GKFWHITDTHYDFMYIEGGDEDKQCREVTYKSKYEKGGASSIGNYKCDTSFELLQSSFEYMVKHEEKPDFIIWTGDDPPH--LGNSQLNETLVLQSITNMTNLIKGYFPDIPIFPSIGNHDSYPQHQIGVGPNWLFENVAQLWS---PFLSNDSIETFKLGGYYTELV---SEGFRIISLNTVFYYNENRQCLNLTDPAGQLLWLNETLANASLAGERVWIIGHVPPGYNEKYDV--FNFHKQFNDEYLFSFSQYSDIIEFHIYGHEHTDTFRLFYDDPNDHINDIEPTGIMFLSPSLTPWMNQFLPALPNNPGLRLYEYNITSFALLDYYQFWTNL-TDNIISGN--IDWQLEYRATEFFNTFNLSPVSM 389
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q92485|ASM3B_HUMAN (Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens OX=9606 GN=SMPDL3B PE=1 SV=2) HSP 1 Score: 177.178 bits (448), Expect = 3.800e-48 Identity = 123/423 (29.08%), Postives = 199/423 (47.04%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327 G FWHI D+HL+ + ++ D +G+Y DS +AL SS+ MK PDFI+ GD++ H + D +L + + +T +R FP T + ++GNHD +P N S+ N + W+ P +SN I FKKG FY + + I+VLN L+Y N+ +DP QF WL+ L A + V++V HV PG E K F FN+++LK+++ + VI FF H HTD+F+++Y+ P+ +F++P VTP+ G V NP++R++ ++ T + Y +L N T W+LEY + P+ SA S+ + + Y + + C E +C + +C +R +D + +CL Sbjct: 21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWK---PWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQG---TPRWELEYQLTEAYGVPDASAHSM---HTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDE--ACSMQHVCAMRQVDIDAYTTCL 429
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|P58242|ASM3B_MOUSE (Acid sphingomyelinase-like phosphodiesterase 3b OS=Mus musculus OX=10090 GN=Smpdl3b PE=1 SV=1) HSP 1 Score: 168.318 bits (425), Expect = 6.981e-45 Identity = 119/427 (27.87%), Postives = 199/427 (46.60%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345 G FWHI D+HL+ ++ ++ + +G+Y DS +AL SS+ MK PDFI+ GD++ H + + + A + +T ++ FP T + ++GNHD +P N S+ N + W P +SN FK+G FY+ + + ++VLN L+Y N +DP QF WL L A V+++ HV PG E K F FN+ +LK+IQ + VI FF H HTD+F++ Y++ P+ +FL+P VTP+ G V NP +R++ ++ + + Y +L N+ T W+ EY + P+ S S+ + + +S Y + ++ TC + SCR +C I+++ + + +CL +K Sbjct: 21 GRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWR---PWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAW-FRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQE---TPRWEQEYRLTEAYQVPDASVSSMH---TALTRIASEPHILQRYYVYNSVSYNHLTCED--SCRIEHVCAIQHVAFNTYATCLHGLGAK 435
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q92484|ASM3A_HUMAN (Acid sphingomyelinase-like phosphodiesterase 3a OS=Homo sapiens OX=9606 GN=SMPDL3A PE=1 SV=2) HSP 1 Score: 155.606 bits (392), Expect = 2.371e-40 Identity = 120/421 (28.50%), Postives = 206/421 (48.93%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDE-TCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G FWH+ D+HL+ ++ + D + +G+ DS + L S+ F+K+S F+I GD+ H + + + I +N+T ++ FP + P++GNHD P + + V +S N W+ P + I T +KG FY+ + T N II LN L+Y N +DP NQF WL++ L ++ + KV+++AHV G S+ +N++ + + Q Y+DVI F+ H H D+ ++ + PV LF++P+VTP ++ + + NP +RL+ ++ QY+ +L N+ +S+ WKLEY+ + +L +SL G +F++ S F +++Y +D TC +T C+ IC I N+D S CL + Sbjct: 38 GQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWK---PWLDEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQ-NITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESI---WKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVS--YDSSVTCDKT--CKAFQICAIMNLDNISYADCLKQ 446
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q3ZC91|ASM3A_BOVIN (Acid sphingomyelinase-like phosphodiesterase 3a OS=Bos taurus OX=9913 GN=SMPDL3A PE=2 SV=1) HSP 1 Score: 151.754 bits (382), Expect = 5.538e-39 Identity = 121/431 (28.07%), Postives = 203/431 (47.10%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFIL----------------NDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISV-NSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPG-----AAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKER 1351 G FWH+ D HL+ ++ + +D +G+ DS + L S++ F+K+S F+I GD+ H + + + I +N+T ++ FP + P++GNHD P + + V NS W+ P ++ I T +KG FYT + + N K II LN L+Y NS +DP NQF WL+ L +++ + KV+++AHV G S K+H N++ + + + Y+D+I F+ H H D+ ++ + +PV LF++P+VTP ++ + + NP VRL+ ++ QY+ +L N+ +S WKLEY + +L KSL +F++ S F ++ Y D + C+ IC I N+D S C + K R Sbjct: 35 GQFWHVTDFHLDPTYHITGDHTKVCASSKGAEASDPGPFGDVMCDSPYRLIFSALDFIKNSGQKVSFMIWTGDSPPHVPVLELSTDKVINVTANITTTIQRLFPNLQVFPALGNHDYWPQDQLPVVNSKVYNAVANLWK---PWLTEDAITTLRKGGFYTQKV-SNNPKLRIISLNTNLYYGPNSVTLNQTDPANQFEWLENTLNISQQNKEKVYIIAHVPVGYLPYARGISAMRKYH------NEKLIDIFRKYSDIIAGQFYGHTHRDSIMVLSDKKGKPVNSLFVAPAVTPVRSVLERLTNNPGVRLFQYDPRDYKLLDMLQYYLNLTDANLKGES---NWKLEYNLTQAYDIQDLQPKSLYKLAKQFAIQESKQFIKYYKYFFVSY---DSSVICQGKCKIFQICAIMNLDVISYTDCFRQYHMKHR 449
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A5K3FBP9 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 244.202 bits (622), Expect = 7.667e-69 Identity = 151/459 (32.90%), Postives = 242/459 (52.72%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILNDIN-RYGNYKDDSTFALFQSSV-LFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPA---TAILPSMGNHDINPANFISVNS------SWCQNFY---KFWESVLPNISNSDIETFKKGCFYTHSI---DTKNSKQ---MIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSR---YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKCASK--------ERKYDW-AWLAVPIVLFLFVILFA 1414 G FW + D+HL+ + + + +G+ DS L S++ K + PDF++ +GD++ H + ++ V L+ FP+ ++PS+GNHD+ P + +SVN WC + W + ++D F GCF++ + T N Q ++I LN +L+ + NS N +DPL QF WL +KLQ AR K ++ H GA E++PV+F + + +N+R + ++ D+ADVI G F HQH D+F++V++ +P++PLF SPSV+P L LGS NP +R Y + SA R Y Q++ +N + W+LEY + + +LS +SL G + + + S++++ L GQPHD CPE S R CR +C +R++ Y+ LDSCL C+SK RK D +W A+PIV + + A Sbjct: 28 GHFWQLTDVHLDLDYERHGCSGDFGDCDCDSPRQLLVSALQATRKIAVAEPDFVVFSGDSTAHAIESETDFERAMKVVATSLKETFPSHRNIPVIPSLGNHDVFPESSMSVNEVDENRRRWCTRLGSDPELWADWVTGPKDADASRFSDGCFFSRLLRINSTANGTQKHLLVISLNGLLYSRRNSQADPNVTDPLGQFQWLLSKLQSARDEKQKAIIIMHFPLGAPENSPVQFRHMYDVYNERLIGILTDFADVISFGLFGHQHVDSFRVVFSKTGDPLLPLFYSPSVSPMYLNALGSFNPRIRFYNYTFGSATPRILDYQQFY-------VNISADQPSWRLEYAARQAYGLADLSPQSLAG-LLARLGDDAAIWCSYWNHELGGQPHDSGPCPELHSKRHCRHLCTMRHLSYSVLDSCLELCSSKPHVVMITSARKTDSDSWNALPIVALVIITFLA 478
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A0R3XA86 (Metallophos domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS10446 PE=4 SV=1) HSP 1 Score: 230.335 bits (586), Expect = 1.049e-63 Identity = 146/464 (31.47%), Postives = 240/464 (51.72%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILNDINRY-GNYKDDSTFALFQSSVLFMKSS-YTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATA----------ILPSMGNHDINPANFISVNSS------WCQNFYK---FWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQ--MIIVLNAILWYQVNSYVK-TNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE-----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHT-HLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKCA------SKERKYDWA--WLAVPIVLFLFVILFA 1414 G FWH+ DIH++ + + G+ + DS L+QS++ + +T PDF++ +GD+ HG I ++ V L+ FP+ + ++ ++GNHD+ P N +SV + WC W + N ++D++ F GCFY+H I + Q II LN + + N ++ DPL QF WL+ +L AR KV +V H GA E++PVKF + + +N R LK++ ++ADV+ G F HQHTD+F+ + +++ + P+I LF +PS++P NL LG+ NP +R++ ++ T + H +H +L +I S + W LEY + + +LSA+SL+ + + + +++ + L G H CPE S R CR +C +RN+ YT+LD+CL C S D A W A+P+V + V A Sbjct: 31 GLFWHLTDIHVDMDYEKHSCQGLLGDQECDSPLRLWQSALNATRQVLHTAPDFVVFSGDSVTHGNITQDAFERTMKIVASALKSVFPSDSSRQQQNNSVPVILTVGNHDVFPDNDMSVEAGDADRRQWCTRLGSSPTLWGDWIANAPDADVDKFNDGCFYSHRIQIGKTGQKLRIISLNGLPYSPRNRRSNLSDPDPLGQFEWLEAQLHSARHESQKVVIVMHFPLGAPENSPVKFRHLYGVYNHRLLKILTEFADVVAFGLFGHQHTDSFRFISSTSEDGTKRNPLISLFSTPSISPMNLTNLGAFNPRIRVFNYSVTPTSLQLHDFHQFYLNLSSITSVA-EAPWSLEYSATKAYNISDLSARSLEA-LMSRLEINQTLWCAYWDHELGGLNHSSGPCPELRSSRHCRHLCTMRNLHYTALDNCLRGCGDASSLVSARPGADQADSWNALPVVALVIVAFLA 492
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A0R3VUU4 (Metallophos domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS1120 PE=4 SV=1) HSP 1 Score: 231.106 bits (588), Expect = 1.075e-63 Identity = 145/461 (31.45%), Postives = 238/461 (51.63%), Query Frame = 2 Query: 152 FWHICDIHLNNSFILNDINR-YGNYKDDSTFALFQSSVLFMKSS-YTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPA----------TAILPSMGNHDINPANFISVNSS------WCQNFY---KFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQM--IIVLNAILWYQVNSYV-KTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE-----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKC------ASKERKYDW--AWLAVPIVLFLFVILFA 1414 FWH+ D+H++ + + G+ K DS +L+ S++ + +T PDF++ +GD+ HG I + ++ V LR+ FP+ ++ ++GNHD+ P N +SV ++ WC + W + N S +D+ F GCFY+ + + Q I+ LN +L+ N +N DPL QF WL T+LQ AR+ KV +V H GA E++PV + + H +NQR L + ++ADV+ G F HQHTD+F+ + ++ E P+I LF +PS++P NL LG+ NP VR++ ++ TS + +H + + S + W LEY + + +LSA SL + + + +++++ L G H CP+ S R CR IC +R++ YT+LD+CL C AS D +W A+P+V + V A Sbjct: 26 FWHLTDVHVDLDYEKHACRGPLGDQKCDSPLSLWLSALNATRQVLHTAPDFVVFSGDSVTHGNIARDEFERTMEKVASALRVVFPSGNSNAQQRNSIPVIVTVGNHDVYPDNEMSVKANDADRRRWCTRLGSSPRLWGDWVANASGADVARFNDGCFYSVRLHIGEAGQTLRIVSLNGLLYSLRNRQSNSSNPDPLGQFQWLTTQLQSARSESQKVIVVMHFPLGAPENSPVDYRHLHDVYNQRLLNIFTEFADVVAFGLFGHQHTDSFRFISSTPKEGTKSNPLISLFNTPSISPMNLTNLGAFNPRVRVFNYSITSTSLHLNDFHQFRINLSKTTPSTKVPWSLEYSATRAYNISDLSAGSL-ASLLTRLEVNHTLWCAYWNHELGGPDHSSGPCPKLHSSRHCRHICTMRHLHYTALDACLHDCDDASSLASARTSTDQVDSWNALPVVALVIVAFLA 485
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A068WK10 (Acid sphingomyelinase phosphodiesterase 3b OS=Echinococcus granulosus OX=6210 GN=EgrG_001109500 PE=4 SV=1) HSP 1 Score: 218.009 bits (554), Expect = 3.082e-59 Identity = 142/473 (30.02%), Postives = 242/473 (51.16%), Query Frame = 2 Query: 131 DSNFQGTFWHICDIHLNNSFILNDINR-YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPAT----------AILPSMGNHDINPANFISVN------SSWCQNF---YKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQM--IIVLNAILWYQVNSYVKTNS---DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE-----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYH---QYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKCA------SKERKYDW--AWLAVPIVLFLFVILFA 1414 D+ G FW + D+H++ ++ + G+ DS +L+ S++ + + PDF++ +GD+ HG I + ++ V L+ FP+ ++ ++GNHD+ P N +SV WC W + N S++D++ F GCFY+ + + + II LN + + N ++NS DPL QF WL +LQ AR K ++ H GA E++PV+FH+ + +NQR L++ ++ DV+ G F HQHTD+F+ + + + E P+IPLF PS++P N LG+ NP VR++ ++ TS H Q++T L + + ++K+ W LEY + + P+LSA+SL+ + + + +++++ L G H CPE S R CR +C +R++ Y +LD+CL C S D +W A+P+V + V A Sbjct: 23 DNIHTGLFWQLTDVHVDLNYEKHACQGPLGDPNCDSPLSLWLSALNATRQVLSSTPDFVVFSGDSVSHGNITQHDFERTMETVASALKAVFPSERSKQQPRSSIPVIVTLGNHDVFPDNDMSVEMDDADRRRWCTRLGSSSTLWGDWIANASDADVDGFNDGCFYSLRLRVGETGKALRIISLNGLFYTPRNR--RSNSSIPDPLGQFQWLTKQLQSARRERQKAIIIMHFPLGAPENSPVEFHHLYEIYNQRLLQIFTEFVDVVAFGLFGHQHTDSFRFISSISEEGAKFVPLIPLFNMPSISPMNFTNLGAFNPRVRVFNYSITSTSIHLHDFYQFYTDLSSTSPDTKA---PWSLEYSATKAYNIPDLSARSLEN-LLTRLKVNRTLWCAYWNHELGGLEHSSGPCPELHSFRHCRHLCTMRHLYYGALDACLRGCGGAPSPTSVRTSTDQVDSWNALPVVALVLVAFLA 489
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A564YHC8 (Metallophos domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6575 PE=4 SV=1) HSP 1 Score: 216.853 bits (551), Expect = 9.931e-59 Identity = 144/461 (31.24%), Postives = 233/461 (50.54%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFI-LNDINRYGNYKDDSTFALFQSSV-LFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFP-----ATAILPSMGNHDINPANFISV------NSSWCQNF---YKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQM-IIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSR---------YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKC--------ASKERKYDWAWLAVPIVLFLFVILFA 1414 G FWH D+H++ + N YG+ DS L+ S++ K T PDF+I +GD+ H A++ V L++ FP + ++ S+GNHD+ P N +SV SWC KFW + N + +D F GCFY+H I N + II LN +L+ + N+ + SDPL QF WL +L+ AR KV +V H GA E++PV F + H +N R LK+ +++DVI G F HQHTD+++++ + + ++PLF PS++P LG P +R++ ++ ++ + +HQ++ NI+S S + W LEYV+ + +LS S+ G + F +++ G H+ CP+ S R CR +C +R++ + +LD CL+ C AS +K D W A+P+++ + V A Sbjct: 28 GLFWHFSDVHVDLDYTNHNCKGPYGDLDCDSPLRLWISALNASRKMVPTRPDFVIFSGDSVAHTTSTLEAFEATMETVASALKVAFPPNREDSIPVILSLGNHDVFPDNRMSVKNDDPIRKSWCTRLGSSTKFWGDWIANETEADSNRFSDGCFYSHFIQVGNRTSLRIISLNGLLYARRNTLGNPSLSDPLGQFAWLIEQLKSARQQNQKVLIVMHFPIGAPENSPVVFRHLHDVYNARILKIFSEFSDVISLGLFGHQHTDSYRVLEVQSGK-MVPLFFIPSISPLYFQNLGGFLPRIRIFNYSVNTSDNSLPPSFEIRDFHQFY-----ANISSTSKS-PWDLEYVATKAYNLSDLSGISMKGLLDSFGNDQELWCSYWYNELGIGMAHESGPCPQLYSKRHCRHMCSLRHVHFPALDECLSICDKIDDSTVASPRKKSDDNWNALPVIVLVIVAFLA 481
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:NCBI gene;Acc:103027922]) HSP 1 Score: 181.8 bits (460), Expect = 7.666e-51 Identity = 129/428 (30.14%), Postives = 206/428 (48.13%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS---ISNVTGELRLHFPATAILPSMGNHDINP-ANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN--FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQL-------GSVNPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G+FWHI D+H + ++ LN D ++G+Y DS + L SS+ M+ PDFII GD++ H +D A I N+T ++ FP+T + ++GNHD +P + +S + K WES L S +TFKKG +YT + + + ++VLN L+Y N + +DP +QF W L A +M KV++V HV PG E K H F PQFN+ +L+LIQ + D+I FF H HTD+F++ Y+ P+ +FL+P VTP W+ G+ NP +R++ ++ + + Y+ +L NI W+ EY F P+ S S+ + + Y + +D C + CR +C +R +D+ + + C+ K Sbjct: 24 GSFWHITDLHWDPTYSLNGNSASVCNSSGNRPTPDAGKFGDYLCDSPWDLINSSMHAMRDILPDPDFIIWTGDDTPHVPNEDLGEEAVLRIIGNLTQIIKELFPSTKVYSALGNHDYHPKSQLPPEQNSIYEQIQKQWESWLDPASR---DTFKKGGYYTEKLLNQTGLR-VLVLNTNLYYDQNKITENINDPADQFRWADQVLSEAAKNMEKVYIVGHVPPGFFEK---KRHKPWFRPQFNKHYLELIQKHHDIIIGQFFGHHHTDSFRLFYDKAGIPISAMFLTPGVTP---WKTTLPGVDDGANNPGIRVFEYDEKTLLVKDMITYYLNLTHANI----ARARWEKEYRLTEAFGVPDASPASM---HHVLEQIAGDNCYLQKYYDFNSVNYDRTAC--GADCRVDHVCAMREVDFDAYELCVVK 432
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:NCBI gene;Acc:103046912]) HSP 1 Score: 148.673 bits (374), Expect = 9.484e-39 Identity = 114/424 (26.89%), Postives = 200/424 (47.17%), Query Frame = 2 Query: 146 GTFWHICDIHLN----------------NSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASIS---NVTGELRLHFPATAILPSMGNHDINPANFISVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVS----PGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFP--NLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G FWHI D+HL+ F + + +G++ DS + L S+ MK P+FII GD+ H ++ +A IS N+T +R FP + P++GNHD P + + ++ + K W P +S+ + T ++G FY+ I ++ LN +Y N + +DP QF WL+ L+L++ S+ KV+++AHV P A ++ ++ H+ N++ + + + Y+ +I F+ H H D+ ++ + +PV +F++P+VTP + + S NP VR+Y+++ G + QY+ +L N K W LEY F ++ +SL +F S F+ +F+ H D TC C+ +C + +D S C+ K Sbjct: 37 GKFWHISDLHLDPTYHITTDPSKVCFSSKGFPVKNPGLFGDFLCDSPYQLILSAFSHMKHVEQQPEFIIWTGDSPPHVPPEELSTDAVISVTSNMTHTIRQFFPQLPVYPALGNHDYWPQDQLPAKTNAVYEAVAKLWA---PWLSSEALATLREGGFYSQLI---KPGLRVVSLNTNFYYTPNKATENLTDPGGQFKWLQDTLELSKQSLEKVYVIAHVPIGYLPYAKDTTAMREHH-----NEKLVDIFRSYSSIIQGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSPGEPFSNNPGVRMYLFDTQDYGLQDLWQYYLNLTEAN---KKEQPNWSLEYTMTEAFAIKDIQPQSLHELALKFEAPQSKDFQKYFT-HFMVSYSDTITC--EGVCKMVQVCSVHYLDRDSYSQCMKK 443
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:ZFIN;Acc:ZDB-GENE-041008-132]) HSP 1 Score: 112.079 bits (279), Expect = 8.610e-27 Identity = 104/427 (24.36%), Postives = 181/427 (42.39%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILND---------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISV-NSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRF--LKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQL-------GSVNPSVRLYVWNGTSAGSRYHQYHTH-LPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327 G FWHI D+H++ ++ + D G+Y+ D+ +AL S++ MK PDFI+ GD++ H + D L I N+T + FP + ++GNHD +P N + N+S W+ + + + TF KG +Y+ + + Q I+VLN L+Y N +DP QF WL L A A+ KVF++ HV PG ++ + +L +G+ + ++V + N V + ++P +TP W+ G+ NP +R++ ++ A + TH + NS ++ W EY F P+ S +LD S ++ Y+ + +D C ++CR C I +D+ + + C+ Sbjct: 22 GKFWHITDLHVDPAYQVTDNSTAVCPSSRDPVLNPGPLGHYQCDAPWALIHSALNNMKRILKNPDFILWTGDDTPH--VPDSALGEEAVLEIIKNLTDIITAAFPGVTVYSALGNHDFHPKNQLPPHNNSIYSRVGSMWQHWM---APESLGTFHKGAYYSEKL-VGRAGQRIVVLNTNLYYASNVQTAGLADPAGQFDWLDKVLTNASANKEKVFIIGHVPPGMXSETREGSGRRECYCDKHYSVARLPHRVTTSAQSGYT--RGGGRGELVRGAGNA-VSSMLIAPGITP---WKTTLPGVDDGANNPGIRVFEYD--KATLQLQDMLTHYIDLQTANSGNLDPVWSQEYSLRLDFSVPDASTAALD---SLLQKMNADPDLFQKYYNFNSVSYDKRAC--DAACRDDHYCAIGEVDFDAYEGCV 429
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc:ZDB-GENE-110411-222]) HSP 1 Score: 82.8037 bits (203), Expect = 4.751e-17 Identity = 85/342 (24.85%), Postives = 142/342 (41.52%), Query Frame = 2 Query: 347 QLNASISNVTGELRLHFPATAILPSMGNHDINPANFISV-------NSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG-----TSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSC 1324 QL A ++ VT +R + T + P++GNH+ +P N +S+W + K W LP+ + + T + G FYT ++ LN N ++ N +DP Q W LQ A + KV ++ H++PG ++ + +I Y I A FF H HTD F++ Y+ + P+ +LSPSVT + W L NP R+Y +G T A +H ++ L N + W+L Y + + + D + + + F +HL + H E C C+ +C +R+ + C Sbjct: 181 QLQA-LTTVTELIRKYLGNTTVYPAVGNHESSPVNSFPPPSAPGHHSSAWLYDAMAKAWSHWLPSDA---LVTLRFGGFYT---ALAKPGLRVVSLNMNFCSVENFWLAINDTDPAGQLQWFVDVLQAAENNGEKVHVIGHIAPGLCRKT----------WSWNYYHIINRYESTIAAQFFGHVHTDQFEMFYDEETLSRPLGVAYLSPSVTTY--WDL---NPGYRVYEIDGDRKDSTRAVLDHHTFYLDLEEANRLDRPT---WRLLYSARKAYGMEALGPADWDALLHRMQDDDALFAIFWWHLH-KGHSSEPC--IGMCKVAMLCALRSGRSGDPEQC 494
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Yeast
Match: PPN1 (Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress [Source:SGD;Acc:S000002860]) HSP 1 Score: 64.6994 bits (156), Expect = 1.839e-11 Identity = 66/295 (22.37%), Postives = 118/295 (40.00%), Query Frame = 2 Query: 131 DSNFQGTFWHICDIHLNNSFILND-------INRYGNYKD------------DSTFALFQSSVLFMKSSYTYP-DFIIVNGDNSYHG--------KIQDYQLNASISNVTGELRLHFPA----------TAILPSMGNHDINPANFISVNSSW-CQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVK---TNSDPLNQ-FMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAF 886 + G F HI DIH + ++ + KD DS L + ++ ++K + DF+I GDN H + Q + +N +++ EL F A +++PS+GN+D+ P N ++ + + +Y+ W++ +P + + F T I K ++ +N + ++ N V + +P Q +W L+ R+ MKV+L HV P A NF +F +Y D+I G + H + D F Sbjct: 90 ERKLHGRFLHITDIHPDPYYVEGSSIDAVCHTGKPSKKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTEL---FSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFALGPTLQTREYYRIWKNFVPQQQQRTFD--RSASFLTEVIP---GKLAVLSINTLYLFKANPLVDNCNSKKEPGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAK--------NFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHF 368
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO31208 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYL6]) HSP 1 Score: 93.9745 bits (232), Expect = 5.381e-21 Identity = 84/292 (28.77%), Postives = 133/292 (45.55%), Query Frame = 2 Query: 281 YTYPDFIIVNGDNSYHGKIQDYQLNASISNVTG--ELRLHF-PATAILPSMGNHDINPANFISVNS-------SWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIV-LNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE--PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGT-SAGSRYHQYHTHLPTGNINSKSVTIEWKLEY 1108 Y+ D+++ GD H I + NA + ++ +L LH+ P + P++GNH+ +P N S SW +N K W + LP + S T KKG FY+ + SK + IV +N +N ++ +S DP Q WL LQ + + KV ++ H+ PG+++ F+ + +I Y + A FF H H+D F++ Y+ P+ FL PSVTP+ NP R+Y +G SR H I + ++W LEY Sbjct: 1 YSQVDYVLWTGDIPPH-NIWNQSRNAQLKSLDNAVDLILHYLPGVKVFPAIGNHEGSPVNSFPPPSITDENSNSWLRNELAKDWGNWLPEYTMS---TIKKGAFYSVLV----SKGLRIVSINMNYCNNMNWWLLLDSIDPAGQLQWLVDTLQESEDNGEKVHIIGHIPPGSSDCLKA--------FSWNYYSIINRYQSTVTAQFFGHTHSDEFEVFYDEKTRRIPISFAFLGPSVTPYQF-----HNPGYRIYDIDGDYDNSSRVVLNHETYILDLIEANKGEVQWTLEY 271
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO46874 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNK9]) HSP 1 Score: 90.8929 bits (224), Expect = 2.475e-19 Identity = 86/342 (25.15%), Postives = 155/342 (45.32%), Query Frame = 2 Query: 230 DSTFALFQSSVLFMKSSYTY--PDFIIVNGDNSYHGKIQDY--------QLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSS---WCQNFYKFWESVL----------PNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSD-------PLNQFMWLKTKLQLARASMMKVFLVAHVSPG--AAESNPVKFHNFHPQFNQRFLKLIQD-YADVIDAGFFAHQHTDAFKIVYNSNNEPVIP---LFLSPSVTPFNLWQLGSVNPSVR-LYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAK 1144 DS +L S + MKS++ DF+++ GD + H + Y +L +SI ++T E+ FP + P GN+D P N + N + Q F +L P ETF G +Y +D + +++ LN++ WY V+++ + SD QF WL+ +L+ A+ KV + +HV PG + +NP+ + ++RF +L+ Y +V+ A + H H D ++ +E + L+PSV+P + + NPS R Y+ Y QY + + ++ + +W+L+Y + +P+ S + Sbjct: 167 DSPMSLMTSWLKHMKSTHEKNPADFLLITGDFNAHRTDESYFPHGSGRQRLLSSIKSITLEIHNAFPDLPVFPLFGNNDFQPHNTLPSNEQDQFYSQALDLFLPMILCDKCSPDRNRPTTQQELRETFVNGGYY--KVDIAGGRMVLLALNSMYWY-VDAHSDSESDSTYIQTKAAQQFNWLEGQLEQAKQQGKKVIITSHVPPGIDSYSNNPLWLDD----ASRRFTELVAGRYHEVVAAQLYGHVHRDDIRLQAIQGDEESVNRSFALLTPSVSP-----IFANNPSYRQFYLHPDQLVLLDYDQYFMDIV---MATQFQSAQWQLDYRFSERYPSTSEQ 493
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO46993 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNV6]) HSP 1 Score: 80.8777 bits (198), Expect = 3.842e-16 Identity = 79/298 (26.51%), Postives = 128/298 (42.95%), Query Frame = 2 Query: 212 YGNYKDDSTFALFQSSVLFMKSSYTY--PDFIIVNGDNSYH---------GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLP-----NISNSDIE---------TFKKGCFYTHSIDTKNSKQMIIVLNAILW--YQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPG----AAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKI-VYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN 1009 YG DS L S V M+S Y DF+I+ GD S H GK + L+ +I + ++ FP + P +GN+D +++ N+S Q + K E P N S D TF G +Y + + + ++++LN++ W Y V Q WL+ +L+ A+ KVF+ H+ PG + P N ++ ++ Y+D++ FFAH H D FK+ ++N++ L+ S T F L +NPSV + N Sbjct: 129 YGRVGCDSPEILIDSLVKGMRSVYDEKGADFMIITGDMSSHKTDASYLPKGKTSERVLH-NIKLASAKIHNAFPKIPVFPMLGNNDFE-GHYVLPNTSHDQWYNKTLEVFAPMILCSNCSTQDTAATTMAELKTTFLDGGYY--KVHIADGRMILLILNSMYWNPYAVEKSYNVQVIAKRQLDWLEQQLEFAKKESKKVFIAGHIPPGIDPFGDKGTPFWMENCTARYTNM---IVGKYSDIVAGQFFAHIHQDDFKLQMFNTSQH------LTGSKTSFAL-----LNPSVSVVYAN 408
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:NCBI gene;Acc:101169562]) HSP 1 Score: 177.563 bits (449), Expect = 3.219e-49 Identity = 131/423 (30.97%), Postives = 197/423 (46.57%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333 G+FWHI D+H + ++ + D R+G+Y DS + L SSV MKS PDFII GD++ H +D A I SN+T + FP T + ++GNHD +P + + + N + W L S +TFKKG +YT + +N +M+ VLN L+Y N + DP +QF W L A A KV+++ HV PG E K F P++N+R+L LI+ + VI FF H HTD+F++ YN + P+ +FLSP VTP+ G V NP +R++ ++ T Y+ +L N + W+ EY F P+ S S+ ++ Y + +D C S CR +C R +D+ + CL K Sbjct: 21 GSFWHITDLHWDPTYEVTDQPELVCASSGKRPALSAGRFGDYVCDSPWHLINSSVYAMKSILPDPDFIIWTGDDTPHVPNEDLGEEAVINIISNLTSAITEIFPHTKVYSALGNHDFHPKSQLPAGPNTIYNRTAELWNHWLELESK---QTFKKGGYYTEKLLNRNGYRML-VLNTNLYYDQNQVTQNMDDPADQFNWADQILTEAAAIKEKVYIIGHVPPGFFEKKRSKPW-FAPKYNRRYLDLIEKHHSVILGQFFGHHHTDSFRMFYNKDRLPISTMFLSPGVTPWETTLPGVVNGANNPGIRVFEYDTDTLLVKDVVTYYLNLTHAN----AARGRWEKEYRLTESFRVPDASPASM---HQTLERLANEHCYLQKYYEFNSVSYDLTDC--GSDCRVDHVCAAREVDFDRYEDCLVK 429
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:NCBI gene;Acc:101171626]) HSP 1 Score: 149.828 bits (377), Expect = 2.229e-39 Identity = 102/351 (29.06%), Postives = 169/351 (48.15%), Query Frame = 2 Query: 146 GTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAE--SNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126 G FWHI D+HL+ ++ L YG++ DS ++L QS+ M DFII GD+ H ++ + I N+T +R HFP + P++GNHD P + + +++ + + W+ P + + + T +G FY+ + ++ LN IL+Y + K SDP QF WL+ L+ A ++ K++++ HV G N H N+R + + + YA VI F+ H H D+ ++ + +PV LF+SP+VTP N+ +L S NP R+Y++N + QY+ +L N KS +W+LEY+ F Sbjct: 32 GRFWHITDLHLDPTYHLAPDPTKVCFSSKGVPAAHAGIYGDFLCDSPYSLIQSAFAHMAPLTQPQDFIIWTGDSPPHVPPDELSTDMVIQVIGNMTHTIREHFPNLTVYPALGNHDYWPQDQMPASTNAIYKAAAELWK---PWLQSEALLTLSEGGFYSQLV---KPGLRLVSLNTILYYGPDQVTKNMSDPAGQFQWLQETLESAAQNLEKIYIIGHVPVGYLPFVKNTTAIQKRH---NERLVSIFRKYAHVIAGHFYGHTHRDSIMVLLDQRGKPVNSLFVSPAVTPIKNVLELYSNNPGFRMYLYNSQDYSMLDIWQYYLNLTEANEKQKS---DWRLEYIMTEAF 370
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:NCBI gene;Acc:101174765]) HSP 1 Score: 79.337 bits (194), Expect = 3.219e-15 Identity = 67/257 (26.07%), Postives = 111/257 (43.19%), Query Frame = 2 Query: 293 DFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHF-PATAILPSMGNHDINPAN-----FISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGS 1027 D++ GD H + +D QL ++ ++ + H P + P++GNH+ P N FI N S + E P + ++T + G FYT I ++ LN + N ++ NS DP NQ WL LQ + KV ++ H+ PG + ++ + +I Y + FF H H D F++ Y+ V F++PSVT + ++NP R+Y+ +G GS Sbjct: 243 DWVYWTGDIPAHNIWSQTRDQQL-MELTVISRLVHKHLGPNVTVYPAVGNHESTPVNSFPPPFIHGNRSSGWLYAAMAEEWAPWLPEPALKTLRYGGFYTVEI---QPGLRVVSLNMNFCARENFWLMVNSTDPANQLQWLVHILQDSEEKGEKVHIIGHIPPGLCLGS----------WSWNYYHIINRYESTVTGQFFGHTHLDEFQMFYDEETMTRAVGVAFVAPSVTTYV-----NLNPGYRVYIVDGNYKGS 480
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000024647.1 (SMESG000024647.1) HSP 1 Score: 855.514 bits (2209), Expect = 0.000e+0 Identity = 450/452 (99.56%), Postives = 451/452 (99.78%), Query Frame = 2 Query: 125 NVDSNFQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHL-PTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFVILFATXXXXXXXXXXXXXNPRYESF 1477 NVDSNFQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHL PTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGFVSEFSLSSSPSFKSFFSYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLF+ILFATFVFRRFYFLRRRLNPRYESF Sbjct: 19 NVDSNFQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGFVSEFSLSSSPSFKSFFSYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFIILFATFVFRRFYFLRRRLNPRYESF 470
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000078127.1 (SMESG000078127.1) HSP 1 Score: 404.06 bits (1037), Expect = 4.609e-135 Identity = 206/405 (50.86%), Postives = 271/405 (66.91%), Query Frame = 2 Query: 140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKT---NSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345 F+G FWH+CD+HLN S+ ++G+YK DS F+L +S+ MK Y PDFII+NGDN H + N S+++V+ EL +FP++ ILPS+GNHD+NPANF S WC+ + W N S +I+TF KGC+Y+ I N +I+LN ++WY NS+ T + DPLNQF WL +L +R S KVFL+ H+ PGA+E +P F + P FN +FLK++QD+AD+IDAGFFAHQHTDAFKIVY+ N++PVIPLF+SPS++PF L LGSVNPSVRLY W A +Y QYH L ++ +K T+ W LEY SN+L P LSA L+ VS+F+ S F FF+YHLSG+PH+ C E+ SCRC ICGI+NIDYT LDSCL C K Sbjct: 19 FKGVFWHVCDVHLNLSYKSFGRKQFGDYKSDSPFSLVKSAFQQMKKIYPNPDFIILNGDNVRHRTVSQSDFNKSLTDVSDELLQNFPSSIILPSLGNHDVNPANFFDPKSQWCRILLEKWLKFFSNNS-LEIQTFTKGCYYSRRITVNNITAKVIILNTMVWYSFNSHTFTTQNSDDPLNQFAWLNKELIESRNSATKVFLIGHIPPGASEYSPTVFRHLRPGFNMKFLKIMQDFADIIDAGFFAHQHTDAFKIVYDHNDKPVIPLFISPSISPFYLSGLGSVNPSVRLYHWRTDPADRKYEQYHAKL--NDVQTK--TLSWSLEYSSNSLIPGLSAFHLNELVSDFTKEDSKHFDKFFTYHLSGRPHEQNECSESISCRCNIICGIQNIDYTKLDSCLKNCPHK 418
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000055453.1 (SMESG000055453.1) HSP 1 Score: 398.282 bits (1022), Expect = 7.761e-134 Identity = 201/425 (47.29%), Postives = 287/425 (67.53%), Query Frame = 2 Query: 140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFVILFA 1414 F+G FWHI DIHLN SF L + YG+YK+D++F L S++ MK+ Y P FII NGDN+YH S+ NV+ E+R +FP ILP++GNHD+NP++ + NS+WC+ FW+ + N S ++ + F KGCFY+ +I + N IIVLN++LWY+ N VK DPL+QF WL +L+ A +VF+V+H+ PGA+E +P KF FH +FN+RFL+++Q+Y+++IDAGFF HQH DAFKIVY++ +P IPLFLSPSV+P +L LGS+NPS+RL+ WN + + +Y QYHT +P N+K+ T+ W LEY S TL+ LSA+ LD F + S +S F+ FF+YHLSG+ H D S+ RC+ +CG+RNIDYT+LD CL KC+ + + W+ + IV+ F++ A Sbjct: 19 FEGIFWHISDIHLNVSFNLGNNRWYGDYKNDASFPLVHSAIKAMKTIYHNPLFIIWNGDNAYHRIANRSNFLESLKNVSSEIRFYFPNANILPTLGNHDVNPSSLFNANSTWCEELLIFWKDFV-NSSENETKRFLKGCFYSRTIKSGNDTVKIIVLNSMLWYRHNKLVKDERDPLSQFSWLMNELEEAAMKKQRVFVVSHIPPGASEFSPKKFRFFHSKFNKRFLEILQNYSNIIDAGFFGHQHVDAFKIVYDTQGKPKIPLFLSPSVSPLHLKGLGSINPSIRLFFWNSSLSNCKYQQYHTTIPNELNNTKNNTLNWILEYDSKTLYSGLSAEDLDNFSLDLSKDNSIYFERFFTYHLSGRSH-DSGASNNSTIRCQIVCGLRNIDYTNLDKCLVKCSDESSTF---WMIIGIVIASFLLALA 438
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000024635.1 (SMESG000024635.1) HSP 1 Score: 351.288 bits (900), Expect = 6.426e-116 Identity = 188/430 (43.72%), Postives = 257/430 (59.77%), Query Frame = 2 Query: 140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERK----YDWAWLAVPIVLFLFVILFAT 1417 F+G FW ICD+HLN S + +G+++ DS+ L +S+ MK Y YPDFIIVNGDN YHG + G L P + ++VNSS C FYK W N S S++ETF KGCFY+ + +K I+ LN +LWY N+YV+ DP NQF+WL+ KL++ R + K FL+ HV PG E + + H Q+N++ L ++QDY DVIDAGFFAHQHTDAFK+V +S+ +P+IP+F SPSVTPFNL +GS+NPS+RLY WN +SA S YHQYHT +P SK+V + W LEY S +L L+A+ L+ + +F +S F FF YHLSGQ H + TCP S CRC+FIC +++ID ++ C +KC ++ K D L + + + IL T Sbjct: 19 FEGAFWDICDLHLNISQPTDINGGFGDFRQDSSIGLIRSAFQEMKKIYPYPDFIIVNGDNVYHGNV-------------GFLE------------------PLHNVNVNSSSCDIFYKVWSVFFQNASQSEVETFIKGCFYSIKVKSKGGNINIVALNTMLWYGRNNYVRALKDPENQFIWLEEKLKIFRKNKEKAFLIGHVPPGILEHSTFIIKHLHSQYNEKLLWIMQDYVDVIDAGFFAHQHTDAFKLVLSSDKKPIIPIFHSPSVTPFNLRGIGSINPSIRLYYWNNSSAASYYHQYHTKIPIVTNISKNVDLSWSLEYNSKSLINGLTAEDLNNLLKDFDQENSKYFDLFFKYHLSGQDHYNLTCPWISKCRCQFICSMQDIDISTAVKCASKCVERDIKPNIESDLKLLKIILPVIFVAILIIT 417
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000071517.1 (SMESG000071517.1) HSP 1 Score: 339.347 bits (869), Expect = 2.585e-111 Identity = 191/425 (44.94%), Postives = 260/425 (61.18%), Query Frame = 2 Query: 140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWL-AVPIVLFLFVILF 1411 FQG FW ICD+HLN S + + GNYK DST L +S+++ MKS Y+ P+FIIVNGDN +HG D + N +I V+ E+ F + ++PS+GNHDI P N I S WC +Y WE L N+ +IE KKGCFY+ +I +KN +++VLN +LWY N DP +QF WL+ ++Q A+ +K+FLV H+ PG +E + + + H FN R + ++Q + I AG FAHQH+DAFK+VYN N+PV+P+FL+PSVTPF L +GSVNPS RLY W+ T+ S Y QYH LP+ N + + W EY S +SA LD +S+F+ +S F FFSYHLSGQ HD+ CP S CR +FIC ++ +DY + SC K+ A L + I L L VILF Sbjct: 19 FQGYFWDICDLHLNISNLNYSLANLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHG---DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGNVLVVVLNTLLWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSN---EKQILAWTKEYSSLEFVAGISAGHLDKLLSDFASKNSTYFNKFFSYHLSGQSHDNAACPYDSQCRHQFICSMKYVDYPAFYSCW-----KQYSRGVALLFKIEISLILNVILF 432 The following BLAST results are available for this feature:
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 4
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 3
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002811 ID=SMED30002811|Name=Acid sphingomyelinase-like phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=1689bpback to top protein sequence of SMED30002811-orf-1 >SMED30002811-orf-1 ID=SMED30002811-orf-1|Name=SMED30002811-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=470bp MEIIKWKLIILIASLLILNVDSNFQGTFWHICDIHLNNSFILNDINRYGNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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