Acid sphingomyelinase-like phosphodiesterase

Overview
NameAcid sphingomyelinase-like phosphodiesterase
Smed IDSMED30002811
Length (bp)1689
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Acid sphingomyelinase-like phosphodiesterase (SMED30002811) t-SNE clustered cells

Violin plots show distribution of expression levels for Acid sphingomyelinase-like phosphodiesterase (SMED30002811) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Acid sphingomyelinase-like phosphodiesterase (SMED30002811) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Acid sphingomyelinase-like phosphodiesterase (SMED30002811) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30002811

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30002811h1SMcG0005629 dd_Smed_v4_8403_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30002811h1SMcG0005629 dd_Smed_v6_17883_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
zeta neoblastSMED30002811h1SMcG0005629 dd_Smed_v4_17883_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416])

HSP 1 Score: 177.178 bits (448), Expect = 7.914e-49
Identity = 123/423 (29.08%), Postives = 199/423 (47.04%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327
            G FWHI D+HL+  + ++                D   +G+Y  DS +AL  SS+  MK     PDFI+  GD++ H  + D +L  +     +  +T  +R  FP T +  ++GNHD +P N     S+   N   + W+   P +SN  I  FKKG FY   +   +    I+VLN  L+Y  N+     +DP  QF WL+  L  A  +   V++V HV PG  E    K   F   FN+++LK+++ +  VI   FF H HTD+F+++Y+    P+  +F++P VTP+     G V    NP++R++ ++  T +      Y  +L   N      T  W+LEY     +  P+ SA S+    +     +         Y  +   +    C E  +C  + +C +R +D  +  +CL
Sbjct:   21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWK---PWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQG---TPRWELEYQLTEAYGVPDASAHSM---HTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDE--ACSMQHVCAMRQVDIDAYTTCL 429          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416])

HSP 1 Score: 167.162 bits (422), Expect = 7.214e-46
Identity = 101/314 (32.17%), Postives = 160/314 (50.96%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN 1009
            G FWHI D+HL+  + ++                D   +G+Y  DS +AL  SS+  MK     PDFI+  GD++ H  + D +L  +     +  +T  +R  FP T +  ++GNHD +P N     S+   N   + W+   P +SN  I  FKKG FY   +   +    I+VLN  L+Y  N+     +DP  QF WL+  L  A  +   V++V HV PG  E    K   F   FN+++LK+++ +  VI   FF H HTD+F+++Y+    P+  +F++P VTP+     G V    NP++R++ ++
Sbjct:   21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWK---PWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYD 328          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3A (sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol;Acc:HGNC:17389])

HSP 1 Score: 155.606 bits (392), Expect = 4.937e-41
Identity = 120/421 (28.50%), Postives = 206/421 (48.93%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDE-TCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
            G FWH+ D+HL+ ++ + D +                 +G+   DS + L  S+  F+K+S     F+I  GD+  H  + +   +  I   +N+T  ++  FP   + P++GNHD  P + + V +S   N     W+   P +    I T +KG FY+  + T N    II LN  L+Y  N      +DP NQF WL++ L  ++ +  KV+++AHV  G   S+          +N++ + + Q Y+DVI   F+ H H D+  ++ +    PV  LF++P+VTP  ++ +  + NP +RL+ ++          QY+ +L   N+  +S+   WKLEY+    +   +L  +SL G   +F++  S  F  +++Y      +D   TC +T  C+   IC I N+D  S   CL +
Sbjct:   38 GQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWK---PWLDEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQ-NITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESI---WKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVS--YDSSVTCDKT--CKAFQICAIMNLDNISYADCLKQ 446          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416])

HSP 1 Score: 132.88 bits (333), Expect = 3.317e-33
Identity = 107/417 (25.66%), Postives = 175/417 (41.97%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327
            G FWHI D+HL+  + ++                D   +G+Y  DS +AL  SS+  MK     PDFI+  GD++ H  + D +L  +               A+L  +                  +   K    V P            G FY   +   +    I+VLN  L+Y  N+     +DP  QF WL+  L  A  +   V++V HV PG  E    K   F   FN+++LK+++ +  VI   FF H HTD+F+++Y+    P+  +F++P VTP+     G V    NP++R++ ++  T +      Y  +L   N      T  W+LEY     +  P+ SA S+    +     +         Y  +   +    C E  +C  + +C +R +D  +  +CL
Sbjct:   21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEA---------------AVLEIV------------------ERLTKLIREVFP------------GAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQG---TPRWELEYQLTEAYGVPDASAHSM---HTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDE--ACSMQHVCAMRQVDIDAYTTCL 381          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3A (sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol;Acc:HGNC:17389])

HSP 1 Score: 130.183 bits (326), Expect = 5.040e-33
Identity = 98/331 (29.61%), Postives = 165/331 (49.85%), Query Frame = 2
Query:  371 VTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDE-TCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345
            +T  ++  FP   + P++GNHD  P + + V +S   N     W+   P +    I T +KG FY+  + T N    II LN  L+Y  N      +DP NQF WL++ L  ++ +  KV+++AHV  G   S+          +N++ + + Q Y+DVI   F+ H H D+  ++ +    PV  LF++P+VTP  ++ +  + NP +RL+ ++          QY+ +L   N+  +S+   WKLEY+    +   +L  +SL G   +F++  S  F  +++Y      +D   TC +T  C+   IC I N+D  S   CL +   K
Sbjct:    1 MTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWK---PWLDEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQ-NITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESI---WKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVS--YDSSVTCDKT--CKAFQICAIMNLDNISYADCLKQLYIK 319          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186012:10190157:-1 gene:WBGene00014106.1 transcript:ZK856.5.3 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5)

HSP 1 Score: 124.02 bits (310), Expect = 2.591e-30
Identity = 96/311 (30.87%), Postives = 145/311 (46.62%), Query Frame = 2
Query:  158 HICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRL-HFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVN-SYVK-TNS-DPLNQFMWLKTKLQLARASMMK--------VFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF--NLWQLGSVNPSVRLY 1000
            H+ D HL+  + +N  N+                YG+Y  D+   L Q ++      +  PD II  GDN  H     +++     N T  L    FP   ILP+ GNHD  P+N     SS     ++ W+  L    + +  TF KG +Y + +    +    +VLN  L+Y  N +YV  TN  DP +QF +L+ +L  A     +        V +VAH+ PG  E  P  F  F  ++N+RFL L   YA+ I    F H HTD F ++ +S    V    ++P+VTP+  +L   G+ NP+ R+Y
Sbjct:   25 HLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESESSLYTKTWELWKGKL---GDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFEKTP-NFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVY 327          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186023:10190366:-1 gene:WBGene00014106.1 transcript:ZK856.5.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5)

HSP 1 Score: 124.02 bits (310), Expect = 2.591e-30
Identity = 96/311 (30.87%), Postives = 145/311 (46.62%), Query Frame = 2
Query:  158 HICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRL-HFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVN-SYVK-TNS-DPLNQFMWLKTKLQLARASMMK--------VFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF--NLWQLGSVNPSVRLY 1000
            H+ D HL+  + +N  N+                YG+Y  D+   L Q ++      +  PD II  GDN  H     +++     N T  L    FP   ILP+ GNHD  P+N     SS     ++ W+  L    + +  TF KG +Y + +    +    +VLN  L+Y  N +YV  TN  DP +QF +L+ +L  A     +        V +VAH+ PG  E  P  F  F  ++N+RFL L   YA+ I    F H HTD F ++ +S    V    ++P+VTP+  +L   G+ NP+ R+Y
Sbjct:   25 HLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESESSLYTKTWELWKGKL---GDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFEKTP-NFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVY 327          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186023:10190131:-1 gene:WBGene00014106.1 transcript:ZK856.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5)

HSP 1 Score: 124.02 bits (310), Expect = 2.591e-30
Identity = 96/311 (30.87%), Postives = 145/311 (46.62%), Query Frame = 2
Query:  158 HICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRL-HFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVN-SYVK-TNS-DPLNQFMWLKTKLQLARASMMK--------VFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF--NLWQLGSVNPSVRLY 1000
            H+ D HL+  + +N  N+                YG+Y  D+   L Q ++      +  PD II  GDN  H     +++     N T  L    FP   ILP+ GNHD  P+N     SS     ++ W+  L    + +  TF KG +Y + +    +    +VLN  L+Y  N +YV  TN  DP +QF +L+ +L  A     +        V +VAH+ PG  E  P  F  F  ++N+RFL L   YA+ I    F H HTD F ++ +S    V    ++P+VTP+  +L   G+ NP+ R+Y
Sbjct:   25 HLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESESSLYTKTWELWKGKL---GDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFEKTP-NFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVY 327          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: asm-3 (Putative sphingomyelin phosphodiesterase asm-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9UAY4])

HSP 1 Score: 75.8702 bits (185), Expect = 3.096e-14
Identity = 90/404 (22.28%), Postives = 167/404 (41.34%), Query Frame = 2
Query:  230 DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS---ISNVTGELRLHFPATAILPSMGNHDINPANFIS-------VNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXY--HLSGQPHDDETCPETSSCRCRFICGIRNIDYTS-----LDSCLTKCASKERKY 1357
            D+ + L  + +  + S+    D+I+V+GD   H  +  Y        + N++  +R +FP T +  ++GNH+  P + I+        +  W  +     W+  +P      +E    GC+     D       +I LN +   ++N ++  N +DP     WL  +LQ A     KV +VAH+     E+      N++        K+I  YA+ +   FF H H++ F ++Y + ++    P   ++ +PSVTP++ +      P+ R+Y  +G   GS Y      ++  +L + N N  +V  +W++ Y S  +   L  +    +        +        Y  H     +D         CR  ++C  R    T      L+  + K   K+ KY
Sbjct:  145 DTPYWLLTNMLQNIASTAGKLDYIMVSGDLVSH-TVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEY--NGCYMKKIYDGLR----MISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYY--------KIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDY-----FPAYRIYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNV--KWEVLYQSANMEYGLKGQIPTEYNQMIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQTQQLCTDLEGGIQKPEPKKNKY 526          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: asm-3 (Putative sphingomyelin phosphodiesterase asm-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9UAY4])

HSP 1 Score: 75.485 bits (184), Expect = 4.154e-14
Identity = 90/404 (22.28%), Postives = 167/404 (41.34%), Query Frame = 2
Query:  230 DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS---ISNVTGELRLHFPATAILPSMGNHDINPANFIS-------VNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXY--HLSGQPHDDETCPETSSCRCRFICGIRNIDYTS-----LDSCLTKCASKERKY 1357
            D+ + L  + +  + S+    D+I+V+GD   H  +  Y        + N++  +R +FP T +  ++GNH+  P + I+        +  W  +     W+  +P      +E    GC+     D       +I LN +   ++N ++  N +DP     WL  +LQ A     KV +VAH+     E+      N++        K+I  YA+ +   FF H H++ F ++Y + ++    P   ++ +PSVTP++ +      P+ R+Y  +G   GS Y      ++  +L + N N  +V  +W++ Y S  +   L  +    +        +        Y  H     +D         CR  ++C  R    T      L+  + K   K+ KY
Sbjct:  189 DTPYWLLTNMLQNIASTAGKLDYIMVSGDLVSH-TVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEY--NGCYMKKIYDGLR----MISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYY--------KIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDY-----FPAYRIYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNV--KWEVLYQSANMEYGLKGQIPTEYNQMIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQTQQLCTDLEGGIQKPEPKKNKY 570          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0347598)

HSP 1 Score: 119.013 bits (297), Expect = 3.026e-28
Identity = 119/493 (24.14%), Postives = 199/493 (40.37%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSF-ILNDINR------------------------YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGK--IQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDP---------------------------------LNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN---FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEY--VSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSG--QPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK--CASKERK------YDWAWLAVPIVLF 1393
            G FWHI D+HL+  +    DI R                        +G+Y  DS + L +S+V  MK+      +F++  GD   H    + + + +  + N+T  L   F +  I P +G+ D          S   +   + W   LP+ +   + TF +G +Y  SI+   S+  I+ LN        ++++ + DP                                   Q++WL+  L  ++     V++V H+ PG  E +    HN   F  + NQR+L +++ +A VI   FF H H+D F+++Y++   P+  L ++PS+ P       S NP++RLY ++ G+     Y Q+   LP  N  ++     W+ EY        P +SA +L          +      F  YH +   + H    CP    C     C I  +DY     CL K   A + R         W+WL   + +F
Sbjct:   26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGSYRRLGELWRHWLPSEA---LVTFDQGGYY--SIEQTKSRLRIVALN-------TNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPT---WQPEYNLTHYYALPEISAVALHN---FAERFTGTDLSWFTRYHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVF 489          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0347599)

HSP 1 Score: 119.013 bits (297), Expect = 3.026e-28
Identity = 119/493 (24.14%), Postives = 199/493 (40.37%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSF-ILNDINR------------------------YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGK--IQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDP---------------------------------LNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN---FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEY--VSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSG--QPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK--CASKERK------YDWAWLAVPIVLF 1393
            G FWHI D+HL+  +    DI R                        +G+Y  DS + L +S+V  MK+      +F++  GD   H    + + + +  + N+T  L   F +  I P +G+ D          S   +   + W   LP+ +   + TF +G +Y  SI+   S+  I+ LN        ++++ + DP                                   Q++WL+  L  ++     V++V H+ PG  E +    HN   F  + NQR+L +++ +A VI   FF H H+D F+++Y++   P+  L ++PS+ P       S NP++RLY ++ G+     Y Q+   LP  N  ++     W+ EY        P +SA +L          +      F  YH +   + H    CP    C     C I  +DY     CL K   A + R         W+WL   + +F
Sbjct:   26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGSYRRLGELWRHWLPSEA---LVTFDQGGYY--SIEQTKSRLRIVALN-------TNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPT---WQPEYNLTHYYALPEISAVALHN---FAERFTGTDLSWFTRYHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVF 489          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0332818)

HSP 1 Score: 119.013 bits (297), Expect = 3.026e-28
Identity = 119/493 (24.14%), Postives = 199/493 (40.37%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSF-ILNDINR------------------------YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGK--IQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDP---------------------------------LNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN---FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEY--VSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSG--QPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK--CASKERK------YDWAWLAVPIVLF 1393
            G FWHI D+HL+  +    DI R                        +G+Y  DS + L +S+V  MK+      +F++  GD   H    + + + +  + N+T  L   F +  I P +G+ D          S   +   + W   LP+ +   + TF +G +Y  SI+   S+  I+ LN        ++++ + DP                                   Q++WL+  L  ++     V++V H+ PG  E +    HN   F  + NQR+L +++ +A VI   FF H H+D F+++Y++   P+  L ++PS+ P       S NP++RLY ++ G+     Y Q+   LP  N  ++     W+ EY        P +SA +L          +      F  YH +   + H    CP    C     C I  +DY     CL K   A + R         W+WL   + +F
Sbjct:   26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHED---------GSGSYRRLGELWRHWLPSEA---LVTFDQGGYY--SIEQTKSRLRIVALN-------TNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPT---WQPEYNLTHYYALPEISAVALHN---FAERFTGTDLSWFTRYHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVF 489          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG3376 (gene:FBgn0034997 transcript:FBtr0072265)

HSP 1 Score: 82.0333 bits (201), Expect = 5.843e-16
Identity = 73/285 (25.61%), Postives = 125/285 (43.86%), Query Frame = 2
Query:  206 NRYGNYKD-DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANF--------ISVNSSWCQNFYKF-WESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG 1012
             ++G+Y+  D+        +  +  ++   D+I+  GD   H    + ++  L A I +   ++   FP   I P++GNH+  P N         + ++ SW  +     W   LP    S   T ++G FY+  +        II LN       N ++  NS DP  +  W   +LQ A  S  KV ++ H+ PG ++   V   NF+        K+I  Y   + A F+ H H D F++ Y+ +  N P    ++ PSV+P+       +NP  R+Y  +G
Sbjct:  313 GKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENL-AIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQ---SVTHTVRRGAFYSVLV---RPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFY--------KIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYY-----DLNPGYRIYYVDG 577          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG3376 (gene:FBgn0034997 transcript:FBtr0072266)

HSP 1 Score: 81.6481 bits (200), Expect = 6.286e-16
Identity = 73/285 (25.61%), Postives = 125/285 (43.86%), Query Frame = 2
Query:  206 NRYGNYKD-DSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANF--------ISVNSSWCQNFYKF-WESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG 1012
             ++G+Y+  D+        +  +  ++   D+I+  GD   H    + ++  L A I +   ++   FP   I P++GNH+  P N         + ++ SW  +     W   LP    S   T ++G FY+  +        II LN       N ++  NS DP  +  W   +LQ A  S  KV ++ H+ PG ++   V   NF+        K+I  Y   + A F+ H H D F++ Y+ +  N P    ++ PSV+P+       +NP  R+Y  +G
Sbjct:  313 GKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENL-AIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQ---SVTHTVRRGAFYSVLV---RPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFY--------KIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYY-----DLNPGYRIYYVDG 577          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:ZFIN;Acc:ZDB-GENE-041008-132])

HSP 1 Score: 180.644 bits (457), Expect = 2.781e-50
Identity = 130/427 (30.44%), Postives = 201/427 (47.07%), Query Frame = 2
Query:  140 FQGTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFIS-VNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
              G FWHI D+H + S+ L+                   RYG+Y  DS ++L  SS+  M+     PDFI+  GD++ H  + D QL        I N+T  ++  FP T +  +MGNHD +P N +    S+  +     W   L   S    ETFK G +YT  +  +   + +IVLN  L+Y  N   +   DP +QF W    LQ A  +  KV+L+ HV PG  E    K   F  +FN+R+++LIQ ++ VI   FF H HTD+F++ YNS   P+  ++L+P VTP+     G +    NP +R++ ++  +   +    Y+ +L   NI        W+ EY     F  P+ S  S+          SS        + L+   +D   C   + CR   +C +R +DY + + C+ K
Sbjct:   21 LTGYFWHISDLHWDPSYDLSSSSQSKCASSGGRPTPHAGRYGDYVCDSPWSLINSSLTAMREILPDPDFIMWTGDDTPH--VPDDQLGEQAVLRIIGNLTNIIKSTFPKTKVYSAMGNHDYHPKNQMPPAKSTIYEQTANLWRDWLHTASQ---ETFKTGGYYTEKLLNQTGLR-VIVLNTNLYYDQNKLTEKVKDPADQFSWADKVLQDAAKNNEKVYLIGHVPPGLFEKKRDKGW-FRKEFNKRYIELIQKHSAVIMGQFFGHHHTDSFRMFYNSKGSPISAMYLTPGVTPWITTLPGVIDGGNNPGIRIFEYDTKTLLVKDIITYYLNLTYANI----ARARWEKEYRLTEAFRVPDASPASM---HRVMERISSEKCSLQKYFELNSVSYDLSEC--HADCRVDHVCALREVDYDAYEKCVLK 431          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:ZFIN;Acc:ZDB-GENE-050327-61])

HSP 1 Score: 146.362 bits (368), Expect = 5.104e-38
Identity = 100/350 (28.57%), Postives = 175/350 (50.00%), Query Frame = 2
Query:  152 FWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPAN-FISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGA---AESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126
            FWHI D+HL+ ++ +                 D   +G++  DS + L  S+  +MK     P+FII  GD+  H   ++   +  I   +N+T  ++  FP   + P++GNHD  P + F +  ++      K W    P ++ + + T +KG FY+  I        ++ LN  L+Y  N      SDP  QF WL+  L+L+R SM KV+++AHV  G    A++      N    +N++ +K+ ++Y++V++  F+ H H D+  ++ +   +PV  +F++P+VTP  +  +  S NP VR Y++   S       Q++ +L   N+  +S    WKLEY+    F
Sbjct:   36 FWHISDLHLDPTYHVTEDHTKVCFSSKGVPALDPGVFGDFLCDSPYQLILSAFSYMKQVDLQPEFIIWTGDSPPHVPKEELSTDVVINVIANMTRTIQQFFPQIPVYPALGNHDYWPQDQFPTSENAIYDAVAKLWS---PWLNPAAVATLQKGGFYSLVI---KPGLRLLSLNTNLYYSPNEVTVNMSDPAGQFQWLQETLELSRQSMEKVYVIAHVPIGYLPFAKNTTAMREN----YNEQLVKIFRNYSEVVEGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSQIEPFSNNPGVRAYLYQPDSYTLLDIWQFYLNLTEANLEQRS---GWKLEYIMTEAF 372          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:ZFIN;Acc:ZDB-GENE-050327-61])

HSP 1 Score: 90.5077 bits (223), Expect = 2.377e-20
Identity = 52/162 (32.10%), Postives = 91/162 (56.17%), Query Frame = 2
Query:  656 SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGA---AESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126
            SDP  QF WL+  L+L+R SM KV+++AHV  G    A++      N+    N++ +K+ ++Y++V++  F+ H H D+  ++ +   +PV  +F++P+VTP  +  +  S NP VR Y++   S       Q++ +L   N+  +S    WKLEY+    F
Sbjct:    3 SDPAGQFQWLQETLELSRQSMEKVYVIAHVPIGYLPFAKNTTAMRENY----NEQLVKIFRNYSEVVEGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSQIEPFSNNPGVRAYLYQPDSYTLLDIWQFYLNLTEANLEQRS---GWKLEYIMTEAF 157          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc:ZDB-GENE-110411-222])

HSP 1 Score: 79.337 bits (194), Expect = 5.052e-15
Identity = 67/255 (26.27%), Postives = 116/255 (45.49%), Query Frame = 2
Query:  293 DFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPA-TAILPSMGNHDINPAN-----FISVN--SSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG 1012
            D++   GD   H    + ++ QLN  ++ ++  +  H      + P++GNH+  P N     F+  N  S W  +   K W   LP  +   +ET ++G FY+  ++       ++ LN     + N ++  NS DP +Q  WL   LQ +     KV ++ H+ PG   S+          ++  +  ++  Y   I   FF H HTD F++ Y+      P+   F++PSVT F      ++NP  R+Y  +G
Sbjct:  322 DWVYWTGDIPAHNVWSQTRNQQLNELVT-ISRLIHKHLGRNVTVYPAVGNHESTPVNSFPPPFVHGNHSSRWLYETMAKEWAPWLPEEA---LETIRRGGFYSVEVE---PGLRLVSLNMNFCSRENYWLMVNSTDPADQLQWLIQILQESENKGEKVHIIGHIPPGFCLSS----------WSWNYYHIVNRYESTITGQFFGHTHTDEFQMFYDEETLTRPLSVAFIAPSVTTFV-----NLNPGYRVYYVDG 554          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: ak9 (adenylate kinase 9 [Source:Xenbase;Acc:XB-GENE-994660])

HSP 1 Score: 179.874 bits (455), Expect = 6.208e-50
Identity = 130/449 (28.95%), Postives = 216/449 (48.11%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSF----------------ILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISV-NSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLW----QLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKER---KYDWAWLAVPIVLFLF 1399
            G FWH+ D+HL+ ++                ++ D  ++GNY  DS   L  SS+  MKS    PDFI+  GD++ H  + + QL        I  +T  ++  FP T +  ++GNHD +P + +   N+S      +FW    P + N  + +F+KG +Y+  +    +   +IVLN  L+Y  NS      DP +QF WL+ +L  A     KV++V HV PG  E    K   F  +FN+R++++IQ +  VI   FF H HTD+F++ Y+ +  PV  +F++P VTP+       + G+ NP +R+  ++  +       Y+ +L   N     V+  W+ EY     +  P+ SA+S+          S+ S      Y  +   +D E C +T  CR   +C IR +D+     C+   +S  R   +    ++ +P+  F F
Sbjct:   21 GYFWHLTDLHLDPNYSVTSDPRKVCPSAGDQLVPDAGQWGNYLCDSPRILINSSINAMKSILPNPDFILWTGDDTPH--VPNEQLGEDAVLEIIRWLTNLIQQTFPTTKVYSALGNHDFHPKSQLPPHNNSIYDRISEFWS---PWLKNESLPSFRKGAYYSEELKDVGAAGRMIVLNTNLYYDSNSLTANMKDPGDQFQWLEDQLNNANLKGEKVYIVGHVPPGYFEKKRDKPW-FREEFNKRYIEIIQKHHRVIQGQFFGHHHTDSFRMFYSDSGTPVSSMFIAPGVTPWKTTLPGVENGANNPGIRVVEYDRQNLQDIV-TYYLNLTYAN----KVSPRWEKEYRLTEAYQIPDCSAQSM---HDVVKKISNDSCYLQKYYKYNSVSYDLEACNKT--CRVDHVCAIREVDFNKYKECVKTESSSIRHMFELTVLFIVMPVYFFTF 453          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: smpdl3a (sphingomyelin phosphodiesterase acid-like 3A [Source:NCBI gene;Acc:595006])

HSP 1 Score: 164.851 bits (416), Expect = 2.324e-44
Identity = 128/437 (29.29%), Postives = 210/437 (48.05%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSF-ILNDINR---------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQ--MIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQ----FNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERK 1354
            G FWHI D+HL+ S+ I  D  +               +G++  DS + L  S++ ++K S+   DF+I  GD+  H  +++      I    N+T  +R   P   + P++GNHD  P + + V  S       +FW+   P ++   + TF+KG +Y+    +  S     II LN  L+Y  N      +DP NQF WL+  L+++R +  KV+++AHV  G      + F    P     FN+R +K+ ++Y+DVI A F+ H H D+  ++ +   +PV  +F++P+VTP  +  +  S NP  RLY ++ T     YH      Y  +L   N+ ++S    W LEY+    +   +L  +SL+G V  F    S  F  ++  +L      D        C+ + IC I+ +D  S   C+    SKE K
Sbjct:   34 GQFWHISDLHLDFSYHITEDRTKVCLSSKGAKASNPGIFGDFVCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTSTIRSLLPDLLVFPALGNHDYWPQDQLPVKESEVYTAVAEFWK---PWLTEEALSTFRKGGYYSQIYKSNKSAHSLRIISLNTNLYYTPNKVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGY-----LPFARLTPAMRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFVTPAVTPIRSALETDSNNPGFRLYQYDTTD----YHLLDLWHYFLNLTEANLKNES---SWNLEYIMTKTYQIKDLQPESLEGLVKRFQQPESIEFLYYYKNYLVSF---DSRVGCDPLCKLQQICAIQYVDEESYTKCI--IGSKEFK 450          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: smpdl3a (sphingomyelin phosphodiesterase acid-like 3A [Source:NCBI gene;Acc:595006])

HSP 1 Score: 162.155 bits (409), Expect = 1.242e-43
Identity = 127/434 (29.26%), Postives = 208/434 (47.93%), Query Frame = 2
Query:  152 FWHICDIHLNNSF-ILNDINR---------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQ--MIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGA---AESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAGSRYH-----QYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERK 1354
            FWHI D+HL+ S+ I  D  +               +G++  DS + L  S++ ++K S+   DF+I  GD+  H  +++      I    N+T  +R   P   + P++GNHD  P + + V  S       +FW+   P ++   + TF+KG +Y+    +  S     II LN  L+Y  N      +DP NQF WL+  L+++R +  KV+++AHV  G    A   P         FN+R +K+ ++Y+DVI A F+ H H D+  ++ +   +PV  +F++P+VTP  +  +  S NP  RLY ++ T     YH      Y  +L   N+ ++S    W LEY+    +   +L  +SL+G V  F    S  F  ++  +L      D        C+ + IC I+ +D  S   C+    SKE K
Sbjct:   12 FWHISDLHLDFSYHITEDRTKVCLSSKGAKASNPGIFGDFVCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTSTIRSLLPDLLVFPALGNHDYWPQDQLPVKESEVYTAVAEFWK---PWLTEEALSTFRKGGYYSQIYKSNKSAHSLRIISLNTNLYYTPNKVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGYLPFARLTPA----MRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFVTPAVTPIRSALETDSNNPGFRLYQYDTTD----YHLLDLWHYFLNLTEANLKNES---SWNLEYIMTKTYQIKDLQPESLEGLVKRFQQPESIEFLYYYKNYLVSF---DSRVGCDPLCKLQQICAIQYVDEESYTKCI--IGSKEFK 426          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: SMPD1 (sphingomyelin phosphodiesterase 1 [Source:NCBI gene;Acc:100487433])

HSP 1 Score: 84.3445 bits (207), Expect = 1.257e-16
Identity = 87/342 (25.44%), Postives = 140/342 (40.94%), Query Frame = 2
Query:  347 QLNASISNVTGELRLHFPATAILPSMGNHDINPANFI-------SVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSR-----YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSC 1324
            QL+A +  +TG +R +  A  + P++GNH+  P N         +++S W   +  + W   LP    S + T +   FYT  I     +  ++ LN       N ++  N +DP  Q  WL   LQ A     KV ++ H+ PG    +          ++  + +++  Y   I A FF H H D F++ Y+      PV   F+SPSVT F      ++NP  R+Y  +G    S      +  Y  +L   N         W L Y +   +   SA   D  +              F Y L  + H DE C E  +C+   +C +R+   +  + C
Sbjct:  179 QLDA-LRTLTGLIRKYLGAVPVYPAVGNHESTPVNSFPPPYVQGNLSSHWLYHSMAQEWHHWLPQ---SALSTLRTAGFYTVPI---GPRLRLVSLNMNFCDLGNFWLLINYTDPAGQLQWLVEVLQEAEEKGEKVHIIGHIPPGLCLKS----------WSWNYYRIVNRYESTIAAQFFGHTHLDEFEMFYDEETLTRPVSVAFISPSVTTFI-----NLNPGYRVYQIDGEYPESSHMVLDHETYILNLTEANARPGQ-DPRWTLLYRALETYGMKSAFPADWELLTRRFLQDERLFQTFWY-LHHKGHVDEVCQE--NCKTTLLCALRSGRSSDPELC 494          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpdl3b (sphingomyelin phosphodiesterase, acid-like 3B [Source:MGI Symbol;Acc:MGI:1916022])

HSP 1 Score: 168.318 bits (425), Expect = 9.980e-46
Identity = 119/427 (27.87%), Postives = 199/427 (46.60%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345
            G FWHI D+HL+ ++ ++                +   +G+Y  DS +AL  SS+  MK     PDFI+  GD++ H     + +  + A +  +T  ++  FP T +  ++GNHD +P N     S+   N   + W    P +SN     FK+G FY+  +   +    ++VLN  L+Y  N      +DP  QF WL   L  A      V+++ HV PG  E    K   F   FN+ +LK+IQ +  VI   FF H HTD+F++ Y++   P+  +FL+P VTP+     G V    NP +R++ ++  +   +    Y  +L   N+     T  W+ EY     +  P+ S  S+    +  +  +S        Y  +   ++  TC +  SCR   +C I+++ + +  +CL    +K
Sbjct:   21 GRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWR---PWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAW-FRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQE---TPRWEQEYRLTEAYQVPDASVSSMH---TALTRIASEPHILQRYYVYNSVSYNHLTCED--SCRIEHVCAIQHVAFNTYATCLHGLGAK 435          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpdl3a (sphingomyelin phosphodiesterase, acid-like 3A [Source:MGI Symbol;Acc:MGI:1931437])

HSP 1 Score: 146.747 bits (369), Expect = 4.984e-38
Identity = 119/424 (28.07%), Postives = 197/424 (46.46%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFIS-VNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVS----PGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
            G FWH+ D+HL+ ++ + D                   +G+   DS + L  S+  F+K+S     F+I  GD+  H  + +      I   +N+T  ++  FP   + P++GNHD  P + +  V S         W+   P +    I T KKG FY+  +   N    II LN  L+Y  N      +DP NQF WL+  L  +  +  KV+++AHV     P A ++  ++ +     +N++ L + + Y+ VI   F+ H H D+  ++ + N  P+  +F++P+VTP   + Q  + NP VRL+ +  G        QY+ +L   N+  +S    W LEYV    +   +L  KSL   V +F+   S  F  ++ Y+         TC +   C+   +C I N+D  S D CL +
Sbjct:   35 GQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWK---PWLGEEAISTLKKGGFYSQKV-ASNPGLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQY-----YNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYKPGDYTLLDMVQYYLNLTEANLKGES---NWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSY-DSSATCDQ--HCKTLQVCAIMNLDSMSYDDCLKQ 443          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpd1 (sphingomyelin phosphodiesterase 1, acid lysosomal [Source:MGI Symbol;Acc:MGI:98325])

HSP 1 Score: 84.7297 bits (208), Expect = 1.023e-16
Identity = 78/295 (26.44%), Postives = 125/295 (42.37%), Query Frame = 2
Query:  293 DFIIVNGDNSYHGKIQDYQLNA--SISNVTGELRLHFPATAILPSMGNHDINPAN-----FISVNSS--WC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRY----HQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126
            + +   GD   H   Q  + +   +++ +T  +R       + P++GNH+  P N     FI  N S  W  +   K WE  LP  +   + T + G FY     T      +I LN     + N ++  NS DP  Q  WL  +LQ A     KV ++ H+ PG    +          ++  + K+I  Y + +   FF H H D F+I Y+    + P+   FL+PS T F      ++NP  R+Y  +G   GS +    H+ +  L     N+   T  WK  Y +   +
Sbjct:  269 EMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADA---LHTLRIGGFYAL---TPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKS----------WSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFI-----NLNPGYRVYQIDGNYPGSSHVVLDHETYI-LNLTQANAAGGTPSWKRLYRARETY 541          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q54SR8|SGMC_DICDI (Sphingomyelinase phosphodiesterase C OS=Dictyostelium discoideum OX=44689 GN=sgmC PE=3 SV=1)

HSP 1 Score: 182.57 bits (462), Expect = 3.173e-50
Identity = 134/371 (36.12%), Postives = 190/371 (51.21%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFI-------------------LNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNA-----SISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNN------EPVIPLFLSPSVTPFNLWQLGSV--NPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFP--NLSAKSL 1150
            G FWHI D H +  +I                       +  GNYK D++F L QSS  +M      PDFII  GD+  H  + + QLN      SI+N+T  ++ +FP   I PS+GNHD  P + I V  +W  +N  + W    P +SN  IETFK G +YT  +   +    II LN + +Y  N      +DP  Q +WL   L  A  +  +V+++ HV PG  E   V   NFH QFN  +L     Y+D+I+   + H+HTD F++ Y+  N      EP   +FLSPS+TP+    L ++  NP +RLY +N TS A   Y+Q+ T+L T NI S +  I+W+LEY +   F   NLS  S+
Sbjct:   32 GKFWHITDTHYDFMYIEGGDEDKQCREVTYKSKYEKGGASSIGNYKCDTSFELLQSSFEYMVKHEEKPDFIIWTGDDPPH--LGNSQLNETLVLQSITNMTNLIKGYFPDIPIFPSIGNHDSYPQHQIGVGPNWLFENVAQLWS---PFLSNDSIETFKLGGYYTELV---SEGFRIISLNTVFYYNENRQCLNLTDPAGQLLWLNETLANASLAGERVWIIGHVPPGYNEKYDV--FNFHKQFNDEYLFSFSQYSDIIEFHIYGHEHTDTFRLFYDDPNDHINDIEPTGIMFLSPSLTPWMNQFLPALPNNPGLRLYEYNITSFALLDYYQFWTNL-TDNIISGN--IDWQLEYRATEFFNTFNLSPVSM 389          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q92485|ASM3B_HUMAN (Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens OX=9606 GN=SMPDL3B PE=1 SV=2)

HSP 1 Score: 177.178 bits (448), Expect = 3.800e-48
Identity = 123/423 (29.08%), Postives = 199/423 (47.04%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327
            G FWHI D+HL+  + ++                D   +G+Y  DS +AL  SS+  MK     PDFI+  GD++ H  + D +L  +     +  +T  +R  FP T +  ++GNHD +P N     S+   N   + W+   P +SN  I  FKKG FY   +   +    I+VLN  L+Y  N+     +DP  QF WL+  L  A  +   V++V HV PG  E    K   F   FN+++LK+++ +  VI   FF H HTD+F+++Y+    P+  +F++P VTP+     G V    NP++R++ ++  T +      Y  +L   N      T  W+LEY     +  P+ SA S+    +     +         Y  +   +    C E  +C  + +C +R +D  +  +CL
Sbjct:   21 GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH--VPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWK---PWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW-FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQG---TPRWELEYQLTEAYGVPDASAHSM---HTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDE--ACSMQHVCAMRQVDIDAYTTCL 429          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|P58242|ASM3B_MOUSE (Acid sphingomyelinase-like phosphodiesterase 3b OS=Mus musculus OX=10090 GN=Smpdl3b PE=1 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 6.981e-45
Identity = 119/427 (27.87%), Postives = 199/427 (46.60%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345
            G FWHI D+HL+ ++ ++                +   +G+Y  DS +AL  SS+  MK     PDFI+  GD++ H     + +  + A +  +T  ++  FP T +  ++GNHD +P N     S+   N   + W    P +SN     FK+G FY+  +   +    ++VLN  L+Y  N      +DP  QF WL   L  A      V+++ HV PG  E    K   F   FN+ +LK+IQ +  VI   FF H HTD+F++ Y++   P+  +FL+P VTP+     G V    NP +R++ ++  +   +    Y  +L   N+     T  W+ EY     +  P+ S  S+    +  +  +S        Y  +   ++  TC +  SCR   +C I+++ + +  +CL    +K
Sbjct:   21 GRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWR---PWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAW-FRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQE---TPRWEQEYRLTEAYQVPDASVSSMH---TALTRIASEPHILQRYYVYNSVSYNHLTCED--SCRIEHVCAIQHVAFNTYATCLHGLGAK 435          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q92484|ASM3A_HUMAN (Acid sphingomyelinase-like phosphodiesterase 3a OS=Homo sapiens OX=9606 GN=SMPDL3A PE=1 SV=2)

HSP 1 Score: 155.606 bits (392), Expect = 2.371e-40
Identity = 120/421 (28.50%), Postives = 206/421 (48.93%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILNDINR----------------YGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDE-TCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
            G FWH+ D+HL+ ++ + D +                 +G+   DS + L  S+  F+K+S     F+I  GD+  H  + +   +  I   +N+T  ++  FP   + P++GNHD  P + + V +S   N     W+   P +    I T +KG FY+  + T N    II LN  L+Y  N      +DP NQF WL++ L  ++ +  KV+++AHV  G   S+          +N++ + + Q Y+DVI   F+ H H D+  ++ +    PV  LF++P+VTP  ++ +  + NP +RL+ ++          QY+ +L   N+  +S+   WKLEY+    +   +L  +SL G   +F++  S  F  +++Y      +D   TC +T  C+   IC I N+D  S   CL +
Sbjct:   38 GQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWK---PWLDEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQ-NITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESI---WKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVS--YDSSVTCDKT--CKAFQICAIMNLDNISYADCLKQ 446          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q3ZC91|ASM3A_BOVIN (Acid sphingomyelinase-like phosphodiesterase 3a OS=Bos taurus OX=9913 GN=SMPDL3A PE=2 SV=1)

HSP 1 Score: 151.754 bits (382), Expect = 5.538e-39
Identity = 121/431 (28.07%), Postives = 203/431 (47.10%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFIL----------------NDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISV-NSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPG-----AAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAG-SRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKER 1351
            G FWH+ D HL+ ++ +                +D   +G+   DS + L  S++ F+K+S     F+I  GD+  H  + +   +  I   +N+T  ++  FP   + P++GNHD  P + + V NS         W+   P ++   I T +KG FYT  + + N K  II LN  L+Y  NS     +DP NQF WL+  L +++ +  KV+++AHV  G        S   K+H      N++ + + + Y+D+I   F+ H H D+  ++ +   +PV  LF++P+VTP  ++ +  + NP VRL+ ++          QY+ +L   N+  +S    WKLEY     +   +L  KSL     +F++  S  F  ++ Y        D +      C+   IC I N+D  S   C  +   K R
Sbjct:   35 GQFWHVTDFHLDPTYHITGDHTKVCASSKGAEASDPGPFGDVMCDSPYRLIFSALDFIKNSGQKVSFMIWTGDSPPHVPVLELSTDKVINVTANITTTIQRLFPNLQVFPALGNHDYWPQDQLPVVNSKVYNAVANLWK---PWLTEDAITTLRKGGFYTQKV-SNNPKLRIISLNTNLYYGPNSVTLNQTDPANQFEWLENTLNISQQNKEKVYIIAHVPVGYLPYARGISAMRKYH------NEKLIDIFRKYSDIIAGQFYGHTHRDSIMVLSDKKGKPVNSLFVAPAVTPVRSVLERLTNNPGVRLFQYDPRDYKLLDMLQYYLNLTDANLKGES---NWKLEYNLTQAYDIQDLQPKSLYKLAKQFAIQESKQFIKYYKYFFVSY---DSSVICQGKCKIFQICAIMNLDVISYTDCFRQYHMKHR 449          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A5K3FBP9 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 244.202 bits (622), Expect = 7.667e-69
Identity = 151/459 (32.90%), Postives = 242/459 (52.72%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILNDIN-RYGNYKDDSTFALFQSSV-LFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPA---TAILPSMGNHDINPANFISVNS------SWCQNFY---KFWESVLPNISNSDIETFKKGCFYTHSI---DTKNSKQ---MIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSR---YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKCASK--------ERKYDW-AWLAVPIVLFLFVILFA 1414
            G FW + D+HL+  +  +  +  +G+   DS   L  S++    K +   PDF++ +GD++ H    +     ++  V   L+  FP+     ++PS+GNHD+ P + +SVN        WC       + W   +    ++D   F  GCF++  +    T N  Q   ++I LN +L+ + NS    N +DPL QF WL +KLQ AR    K  ++ H   GA E++PV+F + +  +N+R + ++ D+ADVI  G F HQH D+F++V++   +P++PLF SPSV+P  L  LGS NP +R Y +   SA  R   Y Q++       +N  +    W+LEY +   +   +LS +SL G +       +  + S++++ L GQPHD   CPE  S R CR +C +R++ Y+ LDSCL  C+SK         RK D  +W A+PIV  + +   A
Sbjct:   28 GHFWQLTDVHLDLDYERHGCSGDFGDCDCDSPRQLLVSALQATRKIAVAEPDFVVFSGDSTAHAIESETDFERAMKVVATSLKETFPSHRNIPVIPSLGNHDVFPESSMSVNEVDENRRRWCTRLGSDPELWADWVTGPKDADASRFSDGCFFSRLLRINSTANGTQKHLLVISLNGLLYSRRNSQADPNVTDPLGQFQWLLSKLQSARDEKQKAIIIMHFPLGAPENSPVQFRHMYDVYNERLIGILTDFADVISFGLFGHQHVDSFRVVFSKTGDPLLPLFYSPSVSPMYLNALGSFNPRIRFYNYTFGSATPRILDYQQFY-------VNISADQPSWRLEYAARQAYGLADLSPQSLAG-LLARLGDDAAIWCSYWNHELGGQPHDSGPCPELHSKRHCRHLCTMRHLSYSVLDSCLELCSSKPHVVMITSARKTDSDSWNALPIVALVIITFLA 478          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A0R3XA86 (Metallophos domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS10446 PE=4 SV=1)

HSP 1 Score: 230.335 bits (586), Expect = 1.049e-63
Identity = 146/464 (31.47%), Postives = 240/464 (51.72%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILNDINRY-GNYKDDSTFALFQSSVLFMKSS-YTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATA----------ILPSMGNHDINPANFISVNSS------WCQNFYK---FWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQ--MIIVLNAILWYQVNSYVK-TNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE-----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHT-HLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKCA------SKERKYDWA--WLAVPIVLFLFVILFA 1414
            G FWH+ DIH++  +  +      G+ + DS   L+QS++   +   +T PDF++ +GD+  HG I       ++  V   L+  FP+ +          ++ ++GNHD+ P N +SV +       WC         W   + N  ++D++ F  GCFY+H I    + Q   II LN + +   N     ++ DPL QF WL+ +L  AR    KV +V H   GA E++PVKF + +  +N R LK++ ++ADV+  G F HQHTD+F+ + +++ +     P+I LF +PS++P NL  LG+ NP +R++ ++ T    + H +H  +L   +I S +    W LEY +   +   +LSA+SL+  +      +   + +++ + L G  H    CPE  S R CR +C +RN+ YT+LD+CL  C       S     D A  W A+P+V  + V   A
Sbjct:   31 GLFWHLTDIHVDMDYEKHSCQGLLGDQECDSPLRLWQSALNATRQVLHTAPDFVVFSGDSVTHGNITQDAFERTMKIVASALKSVFPSDSSRQQQNNSVPVILTVGNHDVFPDNDMSVEAGDADRRQWCTRLGSSPTLWGDWIANAPDADVDKFNDGCFYSHRIQIGKTGQKLRIISLNGLPYSPRNRRSNLSDPDPLGQFEWLEAQLHSARHESQKVVIVMHFPLGAPENSPVKFRHLYGVYNHRLLKILTEFADVVAFGLFGHQHTDSFRFISSTSEDGTKRNPLISLFSTPSISPMNLTNLGAFNPRIRVFNYSVTPTSLQLHDFHQFYLNLSSITSVA-EAPWSLEYSATKAYNISDLSARSLEA-LMSRLEINQTLWCAYWDHELGGLNHSSGPCPELRSSRHCRHLCTMRNLHYTALDNCLRGCGDASSLVSARPGADQADSWNALPVVALVIVAFLA 492          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A0R3VUU4 (Metallophos domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS1120 PE=4 SV=1)

HSP 1 Score: 231.106 bits (588), Expect = 1.075e-63
Identity = 145/461 (31.45%), Postives = 238/461 (51.63%), Query Frame = 2
Query:  152 FWHICDIHLNNSFILNDINR-YGNYKDDSTFALFQSSVLFMKSS-YTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPA----------TAILPSMGNHDINPANFISVNSS------WCQNFY---KFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQM--IIVLNAILWYQVNSYV-KTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE-----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKC------ASKERKYDW--AWLAVPIVLFLFVILFA 1414
            FWH+ D+H++  +  +      G+ K DS  +L+ S++   +   +T PDF++ +GD+  HG I   +   ++  V   LR+ FP+            ++ ++GNHD+ P N +SV ++      WC       + W   + N S +D+  F  GCFY+  +    + Q   I+ LN +L+   N     +N DPL QF WL T+LQ AR+   KV +V H   GA E++PV + + H  +NQR L +  ++ADV+  G F HQHTD+F+ + ++  E     P+I LF +PS++P NL  LG+ NP VR++ ++ TS     + +H      +  + S  + W LEY +   +   +LSA SL   +      +   + +++++ L G  H    CP+  S R CR IC +R++ YT+LD+CL  C      AS     D   +W A+P+V  + V   A
Sbjct:   26 FWHLTDVHVDLDYEKHACRGPLGDQKCDSPLSLWLSALNATRQVLHTAPDFVVFSGDSVTHGNIARDEFERTMEKVASALRVVFPSGNSNAQQRNSIPVIVTVGNHDVYPDNEMSVKANDADRRRWCTRLGSSPRLWGDWVANASGADVARFNDGCFYSVRLHIGEAGQTLRIVSLNGLLYSLRNRQSNSSNPDPLGQFQWLTTQLQSARSESQKVIVVMHFPLGAPENSPVDYRHLHDVYNQRLLNIFTEFADVVAFGLFGHQHTDSFRFISSTPKEGTKSNPLISLFNTPSISPMNLTNLGAFNPRVRVFNYSITSTSLHLNDFHQFRINLSKTTPSTKVPWSLEYSATRAYNISDLSAGSL-ASLLTRLEVNHTLWCAYWNHELGGPDHSSGPCPKLHSSRHCRHICTMRHLHYTALDACLHDCDDASSLASARTSTDQVDSWNALPVVALVIVAFLA 485          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A068WK10 (Acid sphingomyelinase phosphodiesterase 3b OS=Echinococcus granulosus OX=6210 GN=EgrG_001109500 PE=4 SV=1)

HSP 1 Score: 218.009 bits (554), Expect = 3.082e-59
Identity = 142/473 (30.02%), Postives = 242/473 (51.16%), Query Frame = 2
Query:  131 DSNFQGTFWHICDIHLNNSFILNDINR-YGNYKDDSTFALFQSSVLFMKSSYT-YPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPAT----------AILPSMGNHDINPANFISVN------SSWCQNF---YKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQM--IIVLNAILWYQVNSYVKTNS---DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE-----PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYH---QYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKCA------SKERKYDW--AWLAVPIVLFLFVILFA 1414
            D+   G FW + D+H++ ++  +      G+   DS  +L+ S++   +   +  PDF++ +GD+  HG I  +    ++  V   L+  FP+            ++ ++GNHD+ P N +SV         WC         W   + N S++D++ F  GCFY+  +    + +   II LN + +   N   ++NS   DPL QF WL  +LQ AR    K  ++ H   GA E++PV+FH+ +  +NQR L++  ++ DV+  G F HQHTD+F+ + + + E     P+IPLF  PS++P N   LG+ NP VR++ ++ TS     H   Q++T L + + ++K+    W LEY +   +  P+LSA+SL+  +      +   + +++++ L G  H    CPE  S R CR +C +R++ Y +LD+CL  C       S     D   +W A+P+V  + V   A
Sbjct:   23 DNIHTGLFWQLTDVHVDLNYEKHACQGPLGDPNCDSPLSLWLSALNATRQVLSSTPDFVVFSGDSVSHGNITQHDFERTMETVASALKAVFPSERSKQQPRSSIPVIVTLGNHDVFPDNDMSVEMDDADRRRWCTRLGSSSTLWGDWIANASDADVDGFNDGCFYSLRLRVGETGKALRIISLNGLFYTPRNR--RSNSSIPDPLGQFQWLTKQLQSARRERQKAIIIMHFPLGAPENSPVEFHHLYEIYNQRLLQIFTEFVDVVAFGLFGHQHTDSFRFISSISEEGAKFVPLIPLFNMPSISPMNFTNLGAFNPRVRVFNYSITSTSIHLHDFYQFYTDLSSTSPDTKA---PWSLEYSATKAYNIPDLSARSLEN-LLTRLKVNRTLWCAYWNHELGGLEHSSGPCPELHSFRHCRHLCTMRHLYYGALDACLRGCGGAPSPTSVRTSTDQVDSWNALPVVALVLVAFLA 489          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A564YHC8 (Metallophos domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6575 PE=4 SV=1)

HSP 1 Score: 216.853 bits (551), Expect = 9.931e-59
Identity = 144/461 (31.24%), Postives = 233/461 (50.54%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFI-LNDINRYGNYKDDSTFALFQSSV-LFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFP-----ATAILPSMGNHDINPANFISV------NSSWCQNF---YKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQM-IIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSR---------YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCR-CRFICGIRNIDYTSLDSCLTKC--------ASKERKYDWAWLAVPIVLFLFVILFA 1414
            G FWH  D+H++  +   N    YG+   DS   L+ S++    K   T PDF+I +GD+  H         A++  V   L++ FP     +  ++ S+GNHD+ P N +SV        SWC       KFW   + N + +D   F  GCFY+H I   N   + II LN +L+ + N+    + SDPL QF WL  +L+ AR    KV +V H   GA E++PV F + H  +N R LK+  +++DVI  G F HQHTD+++++   + + ++PLF  PS++P     LG   P +R++ ++  ++ +          +HQ++      NI+S S +  W LEYV+   +   +LS  S+ G +  F          +++    G  H+   CP+  S R CR +C +R++ + +LD CL+ C        AS  +K D  W A+P+++ + V   A
Sbjct:   28 GLFWHFSDVHVDLDYTNHNCKGPYGDLDCDSPLRLWISALNASRKMVPTRPDFVIFSGDSVAHTTSTLEAFEATMETVASALKVAFPPNREDSIPVILSLGNHDVFPDNRMSVKNDDPIRKSWCTRLGSSTKFWGDWIANETEADSNRFSDGCFYSHFIQVGNRTSLRIISLNGLLYARRNTLGNPSLSDPLGQFAWLIEQLKSARQQNQKVLIVMHFPIGAPENSPVVFRHLHDVYNARILKIFSEFSDVISLGLFGHQHTDSYRVLEVQSGK-MVPLFFIPSISPLYFQNLGGFLPRIRIFNYSVNTSDNSLPPSFEIRDFHQFY-----ANISSTSKS-PWDLEYVATKAYNLSDLSGISMKGLLDSFGNDQELWCSYWYNELGIGMAHESGPCPQLYSKRHCRHMCSLRHVHFPALDECLSICDKIDDSTVASPRKKSDDNWNALPVIVLVIVAFLA 481          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:NCBI gene;Acc:103027922])

HSP 1 Score: 181.8 bits (460), Expect = 7.666e-51
Identity = 129/428 (30.14%), Postives = 206/428 (48.13%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILN----------------DINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS---ISNVTGELRLHFPATAILPSMGNHDINP-ANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHN--FHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQL-------GSVNPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
            G+FWHI D+H + ++ LN                D  ++G+Y  DS + L  SS+  M+     PDFII  GD++ H   +D    A    I N+T  ++  FP+T +  ++GNHD +P +      +S  +   K WES L   S    +TFKKG +YT  +  +   + ++VLN  L+Y  N   +  +DP +QF W    L  A  +M KV++V HV PG  E    K H   F PQFN+ +L+LIQ + D+I   FF H HTD+F++ Y+    P+  +FL+P VTP   W+        G+ NP +R++ ++  +   +    Y+ +L   NI        W+ EY     F  P+ S  S+          +  +      Y  +   +D   C   + CR   +C +R +D+ + + C+ K
Sbjct:   24 GSFWHITDLHWDPTYSLNGNSASVCNSSGNRPTPDAGKFGDYLCDSPWDLINSSMHAMRDILPDPDFIIWTGDDTPHVPNEDLGEEAVLRIIGNLTQIIKELFPSTKVYSALGNHDYHPKSQLPPEQNSIYEQIQKQWESWLDPASR---DTFKKGGYYTEKLLNQTGLR-VLVLNTNLYYDQNKITENINDPADQFRWADQVLSEAAKNMEKVYIVGHVPPGFFEK---KRHKPWFRPQFNKHYLELIQKHHDIIIGQFFGHHHTDSFRLFYDKAGIPISAMFLTPGVTP---WKTTLPGVDDGANNPGIRVFEYDEKTLLVKDMITYYLNLTHANI----ARARWEKEYRLTEAFGVPDASPASM---HHVLEQIAGDNCYLQKYYDFNSVNYDRTAC--GADCRVDHVCAMREVDFDAYELCVVK 432          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:NCBI gene;Acc:103046912])

HSP 1 Score: 148.673 bits (374), Expect = 9.484e-39
Identity = 114/424 (26.89%), Postives = 200/424 (47.17%), Query Frame = 2
Query:  146 GTFWHICDIHLN----------------NSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASIS---NVTGELRLHFPATAILPSMGNHDINPANFISVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVS----PGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTSAGSR-YHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFP--NLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
            G FWHI D+HL+                  F + +   +G++  DS + L  S+   MK     P+FII  GD+  H   ++   +A IS   N+T  +R  FP   + P++GNHD  P + +   ++   +   K W    P +S+  + T ++G FY+  I        ++ LN   +Y  N   +  +DP  QF WL+  L+L++ S+ KV+++AHV     P A ++  ++ H+     N++ + + + Y+ +I   F+ H H D+  ++ +   +PV  +F++P+VTP  +  +  S NP VR+Y+++    G +   QY+ +L   N   K     W LEY     F   ++  +SL     +F    S  F+ +F+ H      D  TC     C+   +C +  +D  S   C+ K
Sbjct:   37 GKFWHISDLHLDPTYHITTDPSKVCFSSKGFPVKNPGLFGDFLCDSPYQLILSAFSHMKHVEQQPEFIIWTGDSPPHVPPEELSTDAVISVTSNMTHTIRQFFPQLPVYPALGNHDYWPQDQLPAKTNAVYEAVAKLWA---PWLSSEALATLREGGFYSQLI---KPGLRVVSLNTNFYYTPNKATENLTDPGGQFKWLQDTLELSKQSLEKVYVIAHVPIGYLPYAKDTTAMREHH-----NEKLVDIFRSYSSIIQGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSPGEPFSNNPGVRMYLFDTQDYGLQDLWQYYLNLTEAN---KKEQPNWSLEYTMTEAFAIKDIQPQSLHELALKFEAPQSKDFQKYFT-HFMVSYSDTITC--EGVCKMVQVCSVHYLDRDSYSQCMKK 443          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:ZFIN;Acc:ZDB-GENE-041008-132])

HSP 1 Score: 112.079 bits (279), Expect = 8.610e-27
Identity = 104/427 (24.36%), Postives = 181/427 (42.39%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILND---------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNAS-----ISNVTGELRLHFPATAILPSMGNHDINPANFISV-NSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRF--LKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQL-------GSVNPSVRLYVWNGTSAGSRYHQYHTH-LPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCL 1327
            G FWHI D+H++ ++ + D                   G+Y+ D+ +AL  S++  MK     PDFI+  GD++ H  + D  L        I N+T  +   FP   +  ++GNHD +P N +   N+S        W+  +   +   + TF KG +Y+  +    + Q I+VLN  L+Y  N      +DP  QF WL   L  A A+  KVF++ HV PG                ++ +   +L         +G+   +     ++V  + N  V  + ++P +TP   W+        G+ NP +R++ ++   A  +     TH +     NS ++   W  EY     F  P+ S  +LD   S     ++        Y+ +   +D   C   ++CR    C I  +D+ + + C+
Sbjct:   22 GKFWHITDLHVDPAYQVTDNSTAVCPSSRDPVLNPGPLGHYQCDAPWALIHSALNNMKRILKNPDFILWTGDDTPH--VPDSALGEEAVLEIIKNLTDIITAAFPGVTVYSALGNHDFHPKNQLPPHNNSIYSRVGSMWQHWM---APESLGTFHKGAYYSEKL-VGRAGQRIVVLNTNLYYASNVQTAGLADPAGQFDWLDKVLTNASANKEKVFIIGHVPPGMXSETREGSGRRECYCDKHYSVARLPHRVTTSAQSGYT--RGGGRGELVRGAGNA-VSSMLIAPGITP---WKTTLPGVDDGANNPGIRVFEYD--KATLQLQDMLTHYIDLQTANSGNLDPVWSQEYSLRLDFSVPDASTAALD---SLLQKMNADPDLFQKYYNFNSVSYDKRAC--DAACRDDHYCAIGEVDFDAYEGCV 429          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc:ZDB-GENE-110411-222])

HSP 1 Score: 82.8037 bits (203), Expect = 4.751e-17
Identity = 85/342 (24.85%), Postives = 142/342 (41.52%), Query Frame = 2
Query:  347 QLNASISNVTGELRLHFPATAILPSMGNHDINPANFISV-------NSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTN-SDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNG-----TSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSC 1324
            QL A ++ VT  +R +   T + P++GNH+ +P N           +S+W  +   K W   LP+ +   + T + G FYT           ++ LN       N ++  N +DP  Q  W    LQ A  +  KV ++ H++PG               ++  +  +I  Y   I A FF H HTD F++ Y+    + P+   +LSPSVT +  W L   NP  R+Y  +G     T A   +H ++  L   N   +     W+L Y +   +   +    D       +    +  + F +HL  + H  E C     C+   +C +R+      + C
Sbjct:  181 QLQA-LTTVTELIRKYLGNTTVYPAVGNHESSPVNSFPPPSAPGHHSSAWLYDAMAKAWSHWLPSDA---LVTLRFGGFYT---ALAKPGLRVVSLNMNFCSVENFWLAINDTDPAGQLQWFVDVLQAAENNGEKVHVIGHIAPGLCRKT----------WSWNYYHIINRYESTIAAQFFGHVHTDQFEMFYDEETLSRPLGVAYLSPSVTTY--WDL---NPGYRVYEIDGDRKDSTRAVLDHHTFYLDLEEANRLDRPT---WRLLYSARKAYGMEALGPADWDALLHRMQDDDALFAIFWWHLH-KGHSSEPC--IGMCKVAMLCALRSGRSGDPEQC 494          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Yeast
Match: PPN1 (Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress [Source:SGD;Acc:S000002860])

HSP 1 Score: 64.6994 bits (156), Expect = 1.839e-11
Identity = 66/295 (22.37%), Postives = 118/295 (40.00%), Query Frame = 2
Query:  131 DSNFQGTFWHICDIHLNNSFILND-------INRYGNYKD------------DSTFALFQSSVLFMKSSYTYP-DFIIVNGDNSYHG--------KIQDYQLNASISNVTGELRLHFPA----------TAILPSMGNHDINPANFISVNSSW-CQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVK---TNSDPLNQ-FMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAF 886
            +    G F HI DIH +  ++            +    KD            DS   L + ++ ++K +     DF+I  GDN  H         + Q + +N  +++   EL   F A           +++PS+GN+D+ P N  ++  +   + +Y+ W++ +P       +  +   F T  I     K  ++ +N +  ++ N  V    +  +P  Q  +W    L+  R+  MKV+L  HV P A         NF      +F     +Y D+I  G + H + D F
Sbjct:   90 ERKLHGRFLHITDIHPDPYYVEGSSIDAVCHTGKPSKKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTEL---FSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFALGPTLQTREYYRIWKNFVPQQQQRTFD--RSASFLTEVIP---GKLAVLSINTLYLFKANPLVDNCNSKKEPGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAK--------NFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHF 368          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO31208 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYL6])

HSP 1 Score: 93.9745 bits (232), Expect = 5.381e-21
Identity = 84/292 (28.77%), Postives = 133/292 (45.55%), Query Frame = 2
Query:  281 YTYPDFIIVNGDNSYHGKIQDYQLNASISNVTG--ELRLHF-PATAILPSMGNHDINPANFISVNS-------SWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIV-LNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNE--PVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGT-SAGSRYHQYHTHLPTGNINSKSVTIEWKLEY 1108
            Y+  D+++  GD   H  I +   NA + ++    +L LH+ P   + P++GNH+ +P N     S       SW +N   K W + LP  + S   T KKG FY+  +    SK + IV +N      +N ++  +S DP  Q  WL   LQ +  +  KV ++ H+ PG+++            F+  +  +I  Y   + A FF H H+D F++ Y+      P+   FL PSVTP+        NP  R+Y  +G     SR    H       I +    ++W LEY
Sbjct:    1 YSQVDYVLWTGDIPPH-NIWNQSRNAQLKSLDNAVDLILHYLPGVKVFPAIGNHEGSPVNSFPPPSITDENSNSWLRNELAKDWGNWLPEYTMS---TIKKGAFYSVLV----SKGLRIVSINMNYCNNMNWWLLLDSIDPAGQLQWLVDTLQESEDNGEKVHIIGHIPPGSSDCLKA--------FSWNYYSIINRYQSTVTAQFFGHTHSDEFEVFYDEKTRRIPISFAFLGPSVTPYQF-----HNPGYRIYDIDGDYDNSSRVVLNHETYILDLIEANKGEVQWTLEY 271          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO46874 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNK9])

HSP 1 Score: 90.8929 bits (224), Expect = 2.475e-19
Identity = 86/342 (25.15%), Postives = 155/342 (45.32%), Query Frame = 2
Query:  230 DSTFALFQSSVLFMKSSYTY--PDFIIVNGDNSYHGKIQDY--------QLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSS---WCQNFYKFWESVL----------PNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSD-------PLNQFMWLKTKLQLARASMMKVFLVAHVSPG--AAESNPVKFHNFHPQFNQRFLKLIQD-YADVIDAGFFAHQHTDAFKIVYNSNNEPVIP---LFLSPSVTPFNLWQLGSVNPSVR-LYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAK 1144
            DS  +L  S +  MKS++     DF+++ GD + H   + Y        +L +SI ++T E+   FP   + P  GN+D  P N +  N     + Q    F   +L          P       ETF  G +Y   +D    + +++ LN++ WY V+++  + SD          QF WL+ +L+ A+    KV + +HV PG  +  +NP+   +     ++RF +L+   Y +V+ A  + H H D  ++     +E  +      L+PSV+P     + + NPS R  Y+         Y QY   +    + ++  + +W+L+Y  +  +P+ S +
Sbjct:  167 DSPMSLMTSWLKHMKSTHEKNPADFLLITGDFNAHRTDESYFPHGSGRQRLLSSIKSITLEIHNAFPDLPVFPLFGNNDFQPHNTLPSNEQDQFYSQALDLFLPMILCDKCSPDRNRPTTQQELRETFVNGGYY--KVDIAGGRMVLLALNSMYWY-VDAHSDSESDSTYIQTKAAQQFNWLEGQLEQAKQQGKKVIITSHVPPGIDSYSNNPLWLDD----ASRRFTELVAGRYHEVVAAQLYGHVHRDDIRLQAIQGDEESVNRSFALLTPSVSP-----IFANNPSYRQFYLHPDQLVLLDYDQYFMDIV---MATQFQSAQWQLDYRFSERYPSTSEQ 493          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO46993 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNV6])

HSP 1 Score: 80.8777 bits (198), Expect = 3.842e-16
Identity = 79/298 (26.51%), Postives = 128/298 (42.95%), Query Frame = 2
Query:  212 YGNYKDDSTFALFQSSVLFMKSSYTY--PDFIIVNGDNSYH---------GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLP-----NISNSDIE---------TFKKGCFYTHSIDTKNSKQMIIVLNAILW--YQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPG----AAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKI-VYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWN 1009
            YG    DS   L  S V  M+S Y     DF+I+ GD S H         GK  +  L+ +I   + ++   FP   + P +GN+D    +++  N+S  Q + K  E   P     N S  D           TF  G +Y   +   + + ++++LN++ W  Y V            Q  WL+ +L+ A+    KVF+  H+ PG      +  P    N   ++      ++  Y+D++   FFAH H D FK+ ++N++        L+ S T F L     +NPSV +   N
Sbjct:  129 YGRVGCDSPEILIDSLVKGMRSVYDEKGADFMIITGDMSSHKTDASYLPKGKTSERVLH-NIKLASAKIHNAFPKIPVFPMLGNNDFE-GHYVLPNTSHDQWYNKTLEVFAPMILCSNCSTQDTAATTMAELKTTFLDGGYY--KVHIADGRMILLILNSMYWNPYAVEKSYNVQVIAKRQLDWLEQQLEFAKKESKKVFIAGHIPPGIDPFGDKGTPFWMENCTARYTNM---IVGKYSDIVAGQFFAHIHQDDFKLQMFNTSQH------LTGSKTSFAL-----LNPSVSVVYAN 408          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:NCBI gene;Acc:101169562])

HSP 1 Score: 177.563 bits (449), Expect = 3.219e-49
Identity = 131/423 (30.97%), Postives = 197/423 (46.57%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASI---SNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQN-FYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSV----NPSVRLYVWN-GTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF--PNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTK 1333
            G+FWHI D+H + ++ + D                  R+G+Y  DS + L  SSV  MKS    PDFII  GD++ H   +D    A I   SN+T  +   FP T +  ++GNHD +P + +    +   N   + W   L   S    +TFKKG +YT  +  +N  +M+ VLN  L+Y  N   +   DP +QF W    L  A A   KV+++ HV PG  E    K   F P++N+R+L LI+ +  VI   FF H HTD+F++ YN +  P+  +FLSP VTP+     G V    NP +R++ ++  T        Y+ +L   N    +    W+ EY     F  P+ S  S+          ++        Y  +   +D   C   S CR   +C  R +D+   + CL K
Sbjct:   21 GSFWHITDLHWDPTYEVTDQPELVCASSGKRPALSAGRFGDYVCDSPWHLINSSVYAMKSILPDPDFIIWTGDDTPHVPNEDLGEEAVINIISNLTSAITEIFPHTKVYSALGNHDFHPKSQLPAGPNTIYNRTAELWNHWLELESK---QTFKKGGYYTEKLLNRNGYRML-VLNTNLYYDQNQVTQNMDDPADQFNWADQILTEAAAIKEKVYIIGHVPPGFFEKKRSKPW-FAPKYNRRYLDLIEKHHSVILGQFFGHHHTDSFRMFYNKDRLPISTMFLSPGVTPWETTLPGVVNGANNPGIRVFEYDTDTLLVKDVVTYYLNLTHAN----AARGRWEKEYRLTESFRVPDASPASM---HQTLERLANEHCYLQKYYEFNSVSYDLTDC--GSDCRVDHVCAAREVDFDRYEDCLVK 429          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:NCBI gene;Acc:101171626])

HSP 1 Score: 149.828 bits (377), Expect = 2.229e-39
Identity = 102/351 (29.06%), Postives = 169/351 (48.15%), Query Frame = 2
Query:  146 GTFWHICDIHLNNSFILND----------------INRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWC-QNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAE--SNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPF-NLWQLGSVNPSVRLYVWNGTS-AGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLF 1126
            G FWHI D+HL+ ++ L                     YG++  DS ++L QS+   M       DFII  GD+  H    ++    +   I N+T  +R HFP   + P++GNHD  P + +  +++   +   + W+   P + +  + T  +G FY+  +        ++ LN IL+Y  +   K  SDP  QF WL+  L+ A  ++ K++++ HV  G      N       H   N+R + + + YA VI   F+ H H D+  ++ +   +PV  LF+SP+VTP  N+ +L S NP  R+Y++N    +     QY+ +L   N   KS   +W+LEY+    F
Sbjct:   32 GRFWHITDLHLDPTYHLAPDPTKVCFSSKGVPAAHAGIYGDFLCDSPYSLIQSAFAHMAPLTQPQDFIIWTGDSPPHVPPDELSTDMVIQVIGNMTHTIREHFPNLTVYPALGNHDYWPQDQMPASTNAIYKAAAELWK---PWLQSEALLTLSEGGFYSQLV---KPGLRLVSLNTILYYGPDQVTKNMSDPAGQFQWLQETLESAAQNLEKIYIIGHVPVGYLPFVKNTTAIQKRH---NERLVSIFRKYAHVIAGHFYGHTHRDSIMVLLDQRGKPVNSLFVSPAVTPIKNVLELYSNNPGFRMYLYNSQDYSMLDIWQYYLNLTEANEKQKS---DWRLEYIMTEAF 370          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:NCBI gene;Acc:101174765])

HSP 1 Score: 79.337 bits (194), Expect = 3.219e-15
Identity = 67/257 (26.07%), Postives = 111/257 (43.19%), Query Frame = 2
Query:  293 DFIIVNGDNSYH---GKIQDYQLNASISNVTGELRLHF-PATAILPSMGNHDINPAN-----FISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNS-DPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSN--NEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGS 1027
            D++   GD   H    + +D QL   ++ ++  +  H  P   + P++GNH+  P N     FI  N S    +    E   P +    ++T + G FYT  I        ++ LN     + N ++  NS DP NQ  WL   LQ +     KV ++ H+ PG    +          ++  +  +I  Y   +   FF H H D F++ Y+       V   F++PSVT +      ++NP  R+Y+ +G   GS
Sbjct:  243 DWVYWTGDIPAHNIWSQTRDQQL-MELTVISRLVHKHLGPNVTVYPAVGNHESTPVNSFPPPFIHGNRSSGWLYAAMAEEWAPWLPEPALKTLRYGGFYTVEI---QPGLRVVSLNMNFCARENFWLMVNSTDPANQLQWLVHILQDSEEKGEKVHIIGHIPPGLCLGS----------WSWNYYHIINRYESTVTGQFFGHTHLDEFQMFYDEETMTRAVGVAFVAPSVTTYV-----NLNPGYRVYIVDGNYKGS 480          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000024647.1 (SMESG000024647.1)

HSP 1 Score: 855.514 bits (2209), Expect = 0.000e+0
Identity = 450/452 (99.56%), Postives = 451/452 (99.78%), Query Frame = 2
Query:  125 NVDSNFQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHL-PTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFVILFATXXXXXXXXXXXXXNPRYESF 1477
            NVDSNFQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHL PTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGFVSEFSLSSSPSFKSFFSYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLF+ILFATFVFRRFYFLRRRLNPRYESF
Sbjct:   19 NVDSNFQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGFVSEFSLSSSPSFKSFFSYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFIILFATFVFRRFYFLRRRLNPRYESF 470          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000078127.1 (SMESG000078127.1)

HSP 1 Score: 404.06 bits (1037), Expect = 4.609e-135
Identity = 206/405 (50.86%), Postives = 271/405 (66.91%), Query Frame = 2
Query:  140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKT---NSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASK 1345
            F+G FWH+CD+HLN S+      ++G+YK DS F+L +S+   MK  Y  PDFII+NGDN  H  +     N S+++V+ EL  +FP++ ILPS+GNHD+NPANF    S WC+   + W     N S  +I+TF KGC+Y+  I   N    +I+LN ++WY  NS+  T   + DPLNQF WL  +L  +R S  KVFL+ H+ PGA+E +P  F +  P FN +FLK++QD+AD+IDAGFFAHQHTDAFKIVY+ N++PVIPLF+SPS++PF L  LGSVNPSVRLY W    A  +Y QYH  L   ++ +K  T+ W LEY SN+L P LSA  L+  VS+F+   S  F  FF+YHLSG+PH+   C E+ SCRC  ICGI+NIDYT LDSCL  C  K
Sbjct:   19 FKGVFWHVCDVHLNLSYKSFGRKQFGDYKSDSPFSLVKSAFQQMKKIYPNPDFIILNGDNVRHRTVSQSDFNKSLTDVSDELLQNFPSSIILPSLGNHDVNPANFFDPKSQWCRILLEKWLKFFSNNS-LEIQTFTKGCYYSRRITVNNITAKVIILNTMVWYSFNSHTFTTQNSDDPLNQFAWLNKELIESRNSATKVFLIGHIPPGASEYSPTVFRHLRPGFNMKFLKIMQDFADIIDAGFFAHQHTDAFKIVYDHNDKPVIPLFISPSISPFYLSGLGSVNPSVRLYHWRTDPADRKYEQYHAKL--NDVQTK--TLSWSLEYSSNSLIPGLSAFHLNELVSDFTKEDSKHFDKFFTYHLSGRPHEQNECSESISCRCNIICGIQNIDYTKLDSCLKNCPHK 418          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000055453.1 (SMESG000055453.1)

HSP 1 Score: 398.282 bits (1022), Expect = 7.761e-134
Identity = 201/425 (47.29%), Postives = 287/425 (67.53%), Query Frame = 2
Query:  140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFVILFA 1414
            F+G FWHI DIHLN SF L +   YG+YK+D++F L  S++  MK+ Y  P FII NGDN+YH          S+ NV+ E+R +FP   ILP++GNHD+NP++  + NS+WC+    FW+  + N S ++ + F KGCFY+ +I + N    IIVLN++LWY+ N  VK   DPL+QF WL  +L+ A     +VF+V+H+ PGA+E +P KF  FH +FN+RFL+++Q+Y+++IDAGFF HQH DAFKIVY++  +P IPLFLSPSV+P +L  LGS+NPS+RL+ WN + +  +Y QYHT +P    N+K+ T+ W LEY S TL+  LSA+ LD F  + S  +S  F+ FF+YHLSG+ H D      S+ RC+ +CG+RNIDYT+LD CL KC+ +   +   W+ + IV+  F++  A
Sbjct:   19 FEGIFWHISDIHLNVSFNLGNNRWYGDYKNDASFPLVHSAIKAMKTIYHNPLFIIWNGDNAYHRIANRSNFLESLKNVSSEIRFYFPNANILPTLGNHDVNPSSLFNANSTWCEELLIFWKDFV-NSSENETKRFLKGCFYSRTIKSGNDTVKIIVLNSMLWYRHNKLVKDERDPLSQFSWLMNELEEAAMKKQRVFVVSHIPPGASEFSPKKFRFFHSKFNKRFLEILQNYSNIIDAGFFGHQHVDAFKIVYDTQGKPKIPLFLSPSVSPLHLKGLGSINPSIRLFFWNSSLSNCKYQQYHTTIPNELNNTKNNTLNWILEYDSKTLYSGLSAEDLDNFSLDLSKDNSIYFERFFTYHLSGRSH-DSGASNNSTIRCQIVCGLRNIDYTNLDKCLVKCSDESSTF---WMIIGIVIASFLLALA 438          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000024635.1 (SMESG000024635.1)

HSP 1 Score: 351.288 bits (900), Expect = 6.426e-116
Identity = 188/430 (43.72%), Postives = 257/430 (59.77%), Query Frame = 2
Query:  140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERK----YDWAWLAVPIVLFLFVILFAT 1417
            F+G FW ICD+HLN S   +    +G+++ DS+  L +S+   MK  Y YPDFIIVNGDN YHG +             G L                   P + ++VNSS C  FYK W     N S S++ETF KGCFY+  + +K     I+ LN +LWY  N+YV+   DP NQF+WL+ KL++ R +  K FL+ HV PG  E +     + H Q+N++ L ++QDY DVIDAGFFAHQHTDAFK+V +S+ +P+IP+F SPSVTPFNL  +GS+NPS+RLY WN +SA S YHQYHT +P     SK+V + W LEY S +L   L+A+ L+  + +F   +S  F  FF YHLSGQ H + TCP  S CRC+FIC +++ID ++   C +KC  ++ K     D   L + + +    IL  T
Sbjct:   19 FEGAFWDICDLHLNISQPTDINGGFGDFRQDSSIGLIRSAFQEMKKIYPYPDFIIVNGDNVYHGNV-------------GFLE------------------PLHNVNVNSSSCDIFYKVWSVFFQNASQSEVETFIKGCFYSIKVKSKGGNINIVALNTMLWYGRNNYVRALKDPENQFIWLEEKLKIFRKNKEKAFLIGHVPPGILEHSTFIIKHLHSQYNEKLLWIMQDYVDVIDAGFFAHQHTDAFKLVLSSDKKPIIPIFHSPSVTPFNLRGIGSINPSIRLYYWNNSSAASYYHQYHTKIPIVTNISKNVDLSWSLEYNSKSLINGLTAEDLNNLLKDFDQENSKYFDLFFKYHLSGQDHYNLTCPWISKCRCQFICSMQDIDISTAVKCASKCVERDIKPNIESDLKLLKIILPVIFVAILIIT 417          
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000071517.1 (SMESG000071517.1)

HSP 1 Score: 339.347 bits (869), Expect = 2.585e-111
Identity = 191/425 (44.94%), Postives = 260/425 (61.18%), Query Frame = 2
Query:  140 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGXXXXXXXXXXXXXXXXXXYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWL-AVPIVLFLFVILF 1411
            FQG FW ICD+HLN S +   +   GNYK DST  L +S+++ MKS Y+ P+FIIVNGDN +HG   D + N +I  V+ E+   F +  ++PS+GNHDI P N I   S WC  +Y  WE  L N+   +IE  KKGCFY+ +I +KN   +++VLN +LWY  N       DP +QF WL+ ++Q A+   +K+FLV H+ PG +E + +   + H  FN R + ++Q   + I AG FAHQH+DAFK+VYN  N+PV+P+FL+PSVTPF L  +GSVNPS RLY W+ T+  S Y QYH  LP+ N   +   + W  EY S      +SA  LD  +S+F+  +S  F  FFSYHLSGQ HD+  CP  S CR +FIC ++ +DY +  SC      K+     A L  + I L L VILF
Sbjct:   19 FQGYFWDICDLHLNISNLNYSLANLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHG---DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGNVLVVVLNTLLWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSN---EKQILAWTKEYSSLEFVAGISAGHLDKLLSDFASKNSTYFNKFFSYHLSGQSHDNAACPYDSQCRHQFICSMKYVDYPAFYSCW-----KQYSRGVALLFKIEISLILNVILF 432          
The following BLAST results are available for this feature:
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SMPDL3B7.914e-4929.08sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
SMPDL3B7.214e-4632.17sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
SMPDL3A4.937e-4128.50sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
SMPDL3B3.317e-3325.66sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
SMPDL3A5.040e-3329.61sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ZK856.52.591e-3030.87pep chromosome:WBcel235:V:10186012:10190157:-1 gen... [more]
ZK856.52.591e-3030.87pep chromosome:WBcel235:V:10186023:10190366:-1 gen... [more]
ZK856.52.591e-3030.87pep chromosome:WBcel235:V:10186023:10190131:-1 gen... [more]
asm-33.096e-1422.28Putative sphingomyelin phosphodiesterase asm-3 [S... [more]
asm-34.154e-1422.28Putative sphingomyelin phosphodiesterase asm-3 [S... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG320523.026e-2824.14gene:FBgn0044328 transcript:FBtr0347598[more]
CG320523.026e-2824.14gene:FBgn0044328 transcript:FBtr0347599[more]
CG320523.026e-2824.14gene:FBgn0044328 transcript:FBtr0332818[more]
CG33765.843e-1625.61gene:FBgn0034997 transcript:FBtr0072265[more]
CG33766.286e-1625.61gene:FBgn0034997 transcript:FBtr0072266[more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
smpdl3b2.781e-5030.44sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpdl3a5.104e-3828.57sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
smpdl3a2.377e-2032.10sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
smpd15.052e-1526.27sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ak96.208e-5028.95adenylate kinase 9 [Source:Xenbase;Acc:XB-GENE-994... [more]
smpdl3a2.324e-4429.29sphingomyelin phosphodiesterase acid-like 3A [Sour... [more]
smpdl3a1.242e-4329.26sphingomyelin phosphodiesterase acid-like 3A [Sour... [more]
SMPD11.257e-1625.44sphingomyelin phosphodiesterase 1 [Source:NCBI gen... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Smpdl3b9.980e-4627.87sphingomyelin phosphodiesterase, acid-like 3B [Sou... [more]
Smpdl3a4.984e-3828.07sphingomyelin phosphodiesterase, acid-like 3A [Sou... [more]
Smpd11.023e-1626.44sphingomyelin phosphodiesterase 1, acid lysosomal ... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q54SR8|SGMC_DICDI3.173e-5036.12Sphingomyelinase phosphodiesterase C OS=Dictyostel... [more]
sp|Q92485|ASM3B_HUMAN3.800e-4829.08Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
sp|P58242|ASM3B_MOUSE6.981e-4527.87Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
sp|Q92484|ASM3A_HUMAN2.371e-4028.50Acid sphingomyelinase-like phosphodiesterase 3a OS... [more]
sp|Q3ZC91|ASM3A_BOVIN5.538e-3928.07Acid sphingomyelinase-like phosphodiesterase 3a OS... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K3FBP97.667e-6932.90Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A0R3XA861.049e-6331.47Metallophos domain-containing protein OS=Hydatigen... [more]
A0A0R3VUU41.075e-6331.45Metallophos domain-containing protein OS=Taenia as... [more]
A0A068WK103.082e-5930.02Acid sphingomyelinase phosphodiesterase 3b OS=Echi... [more]
A0A564YHC89.931e-5931.24Metallophos domain-containing protein OS=Hymenolep... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
smpdl3b7.666e-5130.14sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpdl3a9.484e-3926.89sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
smpdl3b8.610e-2724.36sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpd14.751e-1724.85sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
PPN11.839e-1122.37Dual endo- and exopolyphosphatase with a role in p... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO312085.381e-2128.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO468742.475e-1925.15Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO469933.842e-1626.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
smpdl3b3.219e-4930.97sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpdl3a2.229e-3929.06sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
smpd13.219e-1526.07sphingomyelin phosphodiesterase 1 [Source:NCBI gen... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000024647.10.000e+099.56SMESG000024647.1[more]
SMESG000078127.14.609e-13550.86SMESG000078127.1[more]
SMESG000055453.17.761e-13447.29SMESG000055453.1[more]
SMESG000024635.16.426e-11643.72SMESG000024635.1[more]
SMESG000071517.12.585e-11144.94SMESG000071517.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002811 ID=SMED30002811|Name=Acid sphingomyelinase-like phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=1689bp
AAAAAATTATGTTTTCTAATTTGTTTTAAAGCATTAATTCTCACGGTATT
TTTAGGAAATATTTCAAATCATGGAGATAATAAAATGGAAATTAATTATA
TTAATTGCATCCTTACTGATTCTGAATGTCGATTCAAACTTTCAGGGCAC
ATTTTGGCATATCTGTGATATACATCTCAACAATTCCTTTATATTAAATG
ATATCAATCGCTATGGGAATTACAAAGATGATTCAACATTTGCTCTATTT
CAATCCTCAGTTCTTTTCATGAAAAGTTCTTATACTTATCCGGATTTTAT
TATTGTAAATGGAGACAATTCGTATCATGGGAAAATTCAGGATTACCAAC
TGAATGCATCAATTAGTAATGTTACAGGTGAATTACGGCTCCATTTTCCA
GCTACCGCCATATTGCCATCTATGGGCAATCACGATATAAACCCAGCCAA
CTTTATCAGTGTCAATTCAAGTTGGTGTCAAAACTTTTACAAATTCTGGG
AATCCGTCCTACCCAACATCTCAAACTCAGATATTGAAACGTTTAAAAAA
GGTTGTTTTTACACCCATTCGATTGACACAAAAAATTCCAAGCAAATGAT
AATTGTGCTAAACGCCATATTGTGGTACCAAGTAAATTCCTATGTAAAGA
CTAACTCAGATCCGTTAAATCAGTTTATGTGGTTGAAAACAAAGCTCCAA
CTCGCTAGGGCGAGTATGATGAAAGTATTCCTTGTTGCTCATGTTTCCCC
TGGTGCGGCAGAGTCAAATCCCGTAAAGTTTCATAACTTCCATCCCCAAT
TTAATCAGAGATTTTTGAAACTCATTCAAGATTATGCGGATGTTATTGAT
GCGGGATTCTTTGCCCACCAGCATACAGATGCCTTCAAGATTGTATATAA
CTCTAACAATGAACCTGTAATACCATTGTTTTTATCGCCCTCGGTTACTC
CATTCAATTTATGGCAACTTGGTTCTGTTAATCCGTCGGTTCGCCTGTAT
GTTTGGAATGGAACAAGTGCTGGAAGTAGATACCATCAATATCATACTCA
CTTGCCCACAGGAAATATCAATTCAAAATCTGTCACAATTGAATGGAAAT
TGGAATATGTTTCCAACACTTTATTTCCAAATTTATCAGCGAAAAGTTTA
GACGGTTTCGTTTCAGAATTTTCTCTTTCGAGTTCTCCTTCGTTTAAGTC
TTTCTTTTCGTATCACTTATCAGGTCAACCCCATGATGATGAGACATGTC
CAGAAACCAGTTCGTGTAGATGTCGATTCATTTGTGGGATCAGAAATATC
GATTACACCTCCCTTGATTCCTGTCTCACTAAATGTGCATCAAAAGAGAG
GAAATATGACTGGGCTTGGCTAGCTGTACCGATTGTTCTTTTTCTTTTTG
TTATTCTGTTCGCCACTTTTGTCTTTCGCAGATTTTATTTCCTCAGGCGT
AGACTCAATCCTCGATATGAATCCTTCTAGAGTTTTCTTTAAGCCGACTT
TTGAAATTTTTGTTGATTTTGAATTTATTGATTTTATTAATTTTTTACCT
TTAAAAGTTTCATTTTCAAATTTGTTTGTGTTTAAATTTTTGACTCAAGT
CGGATTAATAACAATTATTGATTTTCACTTCATATCTGACTGAAAGGTGC
TCCAAATATTCAAATAAAAACTCTCAAGATTAAAAAAAA
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protein sequence of SMED30002811-orf-1

>SMED30002811-orf-1 ID=SMED30002811-orf-1|Name=SMED30002811-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=470bp
MEIIKWKLIILIASLLILNVDSNFQGTFWHICDIHLNNSFILNDINRYGN
YKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISN
VTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNI
SNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLN
QFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLK
LIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQL
GSVNPSVRLYVWNGTSAGSRYHQYHTHLPTGNINSKSVTIEWKLEYVSNT
LFPNLSAKSLDGFVSEFSLSSSPSFKSFFSYHLSGQPHDDETCPETSSCR
CRFICGIRNIDYTSLDSCLTKCASKERKYDWAWLAVPIVLFLFVILFATF
VFRRFYFLRRRLNPRYESF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0004767sphingomyelin phosphodiesterase activity
GO:0046872metal ion binding
GO:0016787hydrolase activity
Vocabulary: cellular component
TermDefinition
GO:0005576extracellular region
GO:0005615extracellular space
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006685sphingomyelin catabolic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
Vocabulary: INTERPRO
TermDefinition
IPR029052Metallo-depent_PP-like
IPR004843Calcineurin-like_PHP_ApaH
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR029052Metallo-dependent phosphatase-likeGENE3DG3DSA:3.60.21.10coord: 27..295
e-value: 3.4E-7
score: 32.2
IPR004843Calcineurin-like phosphoesterase domain, ApaH typePFAMPF00149Metallophoscoord: 27..269
e-value: 8.7E-10
score: 39.4
NoneNo IPR availablePANTHERPTHR10340:SF13SPHINGOMYELINASE PHOSPHODIESTERASE Ccoord: 8..423
NoneNo IPR availablePANTHERPTHR10340SPHINGOMYELIN PHOSPHODIESTERASEcoord: 8..423
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..22
score: 0.778
NoneNo IPR availableSUPERFAMILYSSF56300Metallo-dependent phosphatasescoord: 27..316
NoneNo IPR availableTMHMMTMhelixcoord: 432..454