Lipase
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002769 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Lipase vs. Ensembl Human
Match: LIPM (lipase family member M [Source:HGNC Symbol;Acc:HGNC:23455]) HSP 1 Score: 143.28 bits (360), Expect = 3.588e-41 Identity = 69/120 (57.50%), Postives = 87/120 (72.50%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGL-KNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +++ EA MN+SEII+ GYP E + V TEDGYILS+ RIP GL + T SRPVVLLQHGL+ + ++SN P SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 40 AVDPEAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEM 159
BLAST of Lipase vs. Ensembl Human
Match: LIPA (lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617]) HSP 1 Score: 135.191 bits (339), Expect = 5.411e-40 Identity = 74/149 (49.66%), Postives = 94/149 (63.09%), Query Frame = 3 Query: 30 NLDFVGLSFFILFLGNGLLHAEPS------IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS-RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + F+GL ++ LH+E S ++ E MNVSEII +G+P E + V TEDGYIL L RIP+G KN S +PVV LQHGLL S +V+N SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 2 KMRFLGLVVCLVLW---TLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEM 147
BLAST of Lipase vs. Ensembl Human
Match: LIPA (lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617]) HSP 1 Score: 135.191 bits (339), Expect = 3.492e-39 Identity = 74/148 (50.00%), Postives = 94/148 (63.51%), Query Frame = 3 Query: 33 LDFVGLSFFILFLGNGLLHAEPS------IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS-RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + F+GL ++ LH+E S ++ E MNVSEII +G+P E + V TEDGYIL L RIP+G KN S +PVV LQHGLL S +V+N SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 3 MRFLGLVVCLVLW---TLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEM 147
BLAST of Lipase vs. Ensembl Human
Match: LIPF (lipase F, gastric type [Source:HGNC Symbol;Acc:HGNC:6622]) HSP 1 Score: 135.961 bits (341), Expect = 1.671e-38 Identity = 65/116 (56.03%), Postives = 84/116 (72.41%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 E MN+S++I +GYP E + V TEDGYIL + RIPYG KN+ +T RPVV LQHGLL S+ ++SN P SL FILAD G+DVWL NSRGN ++ ++ YS + EFW F++DEM Sbjct: 30 EVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEM 145
BLAST of Lipase vs. Ensembl Human
Match: LIPF (lipase F, gastric type [Source:HGNC Symbol;Acc:HGNC:6622]) HSP 1 Score: 135.961 bits (341), Expect = 1.941e-38 Identity = 65/116 (56.03%), Postives = 84/116 (72.41%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 E MN+S++I +GYP E + V TEDGYIL + RIPYG KN+ +T RPVV LQHGLL S+ ++SN P SL FILAD G+DVWL NSRGN ++ ++ YS + EFW F++DEM Sbjct: 40 EVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEM 155
BLAST of Lipase vs. Ensembl Celegans
Match: lipl-2 (Lipase [Source:UniProtKB/TrEMBL;Acc:Q20449]) HSP 1 Score: 137.502 bits (345), Expect = 1.712e-39 Identity = 67/148 (45.27%), Postives = 90/148 (60.81%), Query Frame = 3 Query: 18 FMKRNLDFVGLSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTS--TDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 F+ + + SF +L ++A P + E MN S+II+ +GY E+H+VTTEDGYIL +QRIPYG + + RPV+LLQHGLL + +V N P +S F+ AD GFDVWL N RG Y + K +E FW F+WDEM Sbjct: 3 FLAQITCLICTSFLLL----QTINAHPDDDPELNMNTSQIIERWGYKAEVHTVTTEDGYILQMQRIPYGKTSVTWPNGKRPVILLQHGLLACASDWVDNLPTQSAAFVFADAGFDVWLGNVRGTTYGRKNTKLDPSETAFWQFSWDEM 146
BLAST of Lipase vs. Ensembl Celegans
Match: lipl-6 (LIPase Like [Source:UniProtKB/TrEMBL;Acc:E2S7J2]) HSP 1 Score: 135.191 bits (339), Expect = 1.171e-37 Identity = 62/123 (50.41%), Postives = 83/123 (67.48%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS----RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +I+ EA M+V EII +GYP+E H V T DGYIL+L RIP+G TS + +PVV LQHGLL +S ++ N P +S G+I AD G+DVWL N RGN YS H + + ++ FW F+W+EM Sbjct: 173 TIDPEALMDVPEIITHWGYPVETHKVVTVDGYILTLHRIPHGKNETSKSASKTPKPVVFLQHGLLCTSSIWLLNLPRQSAGYIFADQGYDVWLGNMRGNTYSKEHTRMTSADRRFWKFSWEEM 295
BLAST of Lipase vs. Ensembl Celegans
Match: lipl-4 (Lipase [Source:UniProtKB/TrEMBL;Acc:A0A0K3AUZ3]) HSP 1 Score: 130.183 bits (326), Expect = 1.373e-36 Identity = 62/124 (50.00%), Postives = 90/124 (72.58%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLK-NTSTD---SRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQ-EFWDFTWDEM 455 S++ E ++ E+IKS+GY +E+++ TT+DG+IL L RIPYG + TS+D SRPV+ LQHG L SSF +V+N P +S GF+ AD GFDVWL N RGN YS H+ + ++ +FWD++WD++ Sbjct: 27 SVDLEFYLDTPELIKSWGYSVEIYNTTTKDGFILELHRIPYGREVPTSSDVNNSRPVIFLQHGFLCSSFDWVANSPHQSAGFVFADAGFDVWLGNFRGNTYSRKHVSLNPDKDPKFWDWSWDQI 150
BLAST of Lipase vs. Ensembl Celegans
Match: lipl-5 (Lipase [Source:UniProtKB/TrEMBL;Acc:O61866]) HSP 1 Score: 125.561 bits (314), Expect = 5.830e-35 Identity = 59/125 (47.20%), Postives = 79/125 (63.20%), Query Frame = 3 Query: 87 HAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTS--TDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 H +P E M +II+ +GYP +++V T+DGYIL + RIP+G N + RPVV +QHGLL +S +V N P++S GF+ AD GFDVWL N RGN YS H + FWD++WDEM Sbjct: 20 HGDP----ELHMTTPQIIERWGYPAMIYTVATDDGYILEMHRIPFGKTNVTWPNGKRPVVFMQHGLLCASSDWVVNLPDQSAGFLFADAGFDVWLGNMRGNTYSMKHKDLKPSHSAFWDWSWDEM 140
BLAST of Lipase vs. Ensembl Celegans
Match: lipl-5 (Lipase [Source:UniProtKB/TrEMBL;Acc:O61866]) HSP 1 Score: 125.561 bits (314), Expect = 5.830e-35 Identity = 59/125 (47.20%), Postives = 79/125 (63.20%), Query Frame = 3 Query: 87 HAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTS--TDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 H +P E M +II+ +GYP +++V T+DGYIL + RIP+G N + RPVV +QHGLL +S +V N P++S GF+ AD GFDVWL N RGN YS H + FWD++WDEM Sbjct: 20 HGDP----ELHMTTPQIIERWGYPAMIYTVATDDGYILEMHRIPFGKTNVTWPNGKRPVVFMQHGLLCASSDWVVNLPDQSAGFLFADAGFDVWLGNMRGNTYSMKHKDLKPSHSAFWDWSWDEM 140
BLAST of Lipase vs. Ensembl Fly
Match: Lip4 (gene:FBgn0032264 transcript:FBtr0304119) HSP 1 Score: 131.339 bits (329), Expect = 6.472e-37 Identity = 63/125 (50.40%), Postives = 85/125 (68.00%), Query Frame = 3 Query: 90 AEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRP---VVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +P+I+E++ +N +IK YGYP E H++ T+DGYIL+L RI +RP VLL HGLLDSS T+V GP K LG++L D G+DVW++N RGN YS H+KYS + +FWDFT+ EM Sbjct: 59 VDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRI----------ARPGATPVLLVHGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEM 173
BLAST of Lipase vs. Ensembl Fly
Match: Lip4 (gene:FBgn0032264 transcript:FBtr0080093) HSP 1 Score: 131.339 bits (329), Expect = 7.395e-37 Identity = 63/125 (50.40%), Postives = 85/125 (68.00%), Query Frame = 3 Query: 90 AEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRP---VVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +P+I+E++ +N +IK YGYP E H++ T+DGYIL+L RI +RP VLL HGLLDSS T+V GP K LG++L D G+DVW++N RGN YS H+KYS + +FWDFT+ EM Sbjct: 59 VDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRI----------ARPGATPVLLVHGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEM 173
BLAST of Lipase vs. Ensembl Fly
Match: Lip4 (gene:FBgn0032264 transcript:FBtr0331672) HSP 1 Score: 131.724 bits (330), Expect = 7.782e-37 Identity = 71/155 (45.81%), Postives = 98/155 (63.23%), Query Frame = 3 Query: 9 LFNFMKRNLDFVGLSFFI---LFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRP---VVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 LFN + F+G S + + L N + +P+I+E++ +N +IK YGYP E H++ T+DGYIL+L RI +RP VLL HGLLDSS T+V GP K LG++L D G+DVW++N RGN YS H+KYS + +FWDFT+ EM Sbjct: 46 LFNVNFKTPTFLGRSVAVDSNVRLENDV---DPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRI----------ARPGATPVLLVHGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEM 187
BLAST of Lipase vs. Ensembl Fly
Match: mag (gene:FBgn0036996 transcript:FBtr0078196) HSP 1 Score: 125.946 bits (315), Expect = 4.485e-35 Identity = 61/125 (48.80%), Postives = 85/125 (68.00%), Query Frame = 3 Query: 102 IEEEAKMNVSEIIKS------YGYPLEMHSVTTEDGYILSLQRIPYGLK-NTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + E++ +SEI+KS +GYP E H VTT+DGY+L+L RIPY K + RP +LLQHGL +S ++S+GP+ SL ++LAD G+DVWL N+RGNIYS ++I S N +FW F W E+ Sbjct: 18 LAEKSDYCLSEIVKSDERIRSHGYPTETHEVTTQDGYVLTLFRIPYSHKLKNQNEKRPPILLQHGLFSNSDCWLSSGPDNSLAYLLADAGYDVWLGNARGNIYSRNNIIISLNSHKFWHFDWHEI 142
BLAST of Lipase vs. Ensembl Fly
Match: CG18302 (gene:FBgn0032266 transcript:FBtr0080095) HSP 1 Score: 123.635 bits (309), Expect = 3.783e-34 Identity = 60/139 (43.17%), Postives = 86/139 (61.87%), Query Frame = 3 Query: 39 FVGLSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + L F L+ + +I E+A + ++IK YGYP E H + +DG++L+ RIP +PV LL HGLLDSS YV GPE+SLGF+L+D G+DVWL N+RGN YS H +Y + + +FWDF++ E+ Sbjct: 14 LISLFIFCDTASGDLIKVDKTILEDANLITPDLIKKYGYPAETHKIQAKDGFVLTAHRIP------KPGGQPV-LLVHGLLDSSVAYVILGPERSLGFLLSDMGYDVWLLNTRGNRYSRKHKRYHRYQPQFWDFSFHEL 145
BLAST of Lipase vs. Ensembl Zebrafish
Match: lipf (lipase, gastric [Source:ZFIN;Acc:ZDB-GENE-040426-2737]) HSP 1 Score: 142.895 bits (359), Expect = 2.262e-41 Identity = 63/118 (53.39%), Postives = 85/118 (72.03%), Query Frame = 3 Query: 102 IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 ++ E MN+SEII+ +GYP E V TEDGYILS+ RIP+G+KN + + +PVV LQHGLL + +V+N P SLGF+LAD GFDVW+ NSRGN +S H+ ++E+W F+ DEM Sbjct: 28 LDPEVNMNISEIIRHWGYPAEEFEVVTEDGYILSINRIPHGVKNKNEEVKPVVFLQHGLLAAGSNWVTNLPNNSLGFVLADAGFDVWIGNSRGNTWSCKHVSLDPRQKEYWKFSHDEM 145
BLAST of Lipase vs. Ensembl Zebrafish
Match: lipf (lipase, gastric [Source:ZFIN;Acc:ZDB-GENE-040426-2737]) HSP 1 Score: 142.895 bits (359), Expect = 2.262e-41 Identity = 63/118 (53.39%), Postives = 85/118 (72.03%), Query Frame = 3 Query: 102 IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 ++ E MN+SEII+ +GYP E V TEDGYILS+ RIP+G+KN + + +PVV LQHGLL + +V+N P SLGF+LAD GFDVW+ NSRGN +S H+ ++E+W F+ DEM Sbjct: 28 LDPEVNMNISEIIRHWGYPAEEFEVVTEDGYILSINRIPHGVKNKNEEVKPVVFLQHGLLAAGSNWVTNLPNNSLGFVLADAGFDVWIGNSRGNTWSCKHVSLDPRQKEYWKFSHDEM 145
BLAST of Lipase vs. Ensembl Xenopus
Match: lipa (lipase A, lysosomal acid, cholesterol esterase [Source:NCBI gene;Acc:548564]) HSP 1 Score: 136.346 bits (342), Expect = 2.621e-38 Identity = 64/119 (53.78%), Postives = 84/119 (70.59%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 S + EA MN+SE+I+ GYP E + V TEDGYILS+ RIP+G+K S +PVV LQHGLL +V+N SLGFILAD G+DVW+ NSRGN +S H S +++EFW F++DE+ Sbjct: 82 SADPEATMNISELIRYRGYPSEEYEVLTEDGYILSVNRIPHGVKYASEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYDVWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDEL 200
BLAST of Lipase vs. Ensembl Xenopus
Match: lipa (lipase A, lysosomal acid, cholesterol esterase [Source:NCBI gene;Acc:548564]) HSP 1 Score: 125.946 bits (315), Expect = 6.144e-35 Identity = 60/116 (51.72%), Postives = 81/116 (69.83%), Query Frame = 3 Query: 111 EAKMNV-SEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + +M+ SE+I+ GYP E + V TEDGYILS+ RIP+G+K S +PVV LQHGLL +V+N SLGFILAD G+DVW+ NSRGN +S H S +++EFW F++DE+ Sbjct: 3 DCRMHCPSELIRYRGYPSEEYEVLTEDGYILSVNRIPHGVKYASEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYDVWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDEL 118
BLAST of Lipase vs. Ensembl Xenopus
Match: lipa (lipase A, lysosomal acid, cholesterol esterase [Source:NCBI gene;Acc:548564]) HSP 1 Score: 125.561 bits (314), Expect = 8.188e-35 Identity = 59/114 (51.75%), Postives = 78/114 (68.42%), Query Frame = 3 Query: 114 AKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 A + E+I+ GYP E + V TEDGYILS+ RIP+G+K S +PVV LQHGLL +V+N SLGFILAD G+DVW+ NSRGN +S H S +++EFW F++DE+ Sbjct: 7 ASYQIFELIRYRGYPSEEYEVLTEDGYILSVNRIPHGVKYASEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYDVWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDEL 120
BLAST of Lipase vs. Ensembl Xenopus
Match: lipa (lipase A, lysosomal acid, cholesterol esterase [Source:NCBI gene;Acc:548564]) HSP 1 Score: 125.561 bits (314), Expect = 1.144e-34 Identity = 59/112 (52.68%), Postives = 79/112 (70.54%), Query Frame = 3 Query: 120 MNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 ++ SE+I+ GYP E + V TEDGYILS+ RIP+G+K S +PVV LQHGLL +V+N SLGFILAD G+DVW+ NSRGN +S H S +++EFW F++DE+ Sbjct: 30 ISSSELIRYRGYPSEEYEVLTEDGYILSVNRIPHGVKYASEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYDVWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDEL 141
BLAST of Lipase vs. Ensembl Xenopus
Match: lipa (lipase A, lysosomal acid, cholesterol esterase [Source:NCBI gene;Acc:548564]) HSP 1 Score: 124.02 bits (310), Expect = 2.339e-34 Identity = 58/108 (53.70%), Postives = 76/108 (70.37%), Query Frame = 3 Query: 132 EIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 E+I+ GYP E + V TEDGYILS+ RIP+G+K S +PVV LQHGLL +V+N SLGFILAD G+DVW+ NSRGN +S H S +++EFW F++DE+ Sbjct: 3 ELIRYRGYPSEEYEVLTEDGYILSVNRIPHGVKYASEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYDVWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDEL 110
BLAST of Lipase vs. Ensembl Mouse
Match: Lipm (lipase, family member M [Source:MGI Symbol;Acc:MGI:1926003]) HSP 1 Score: 139.043 bits (349), Expect = 9.739e-40 Identity = 70/120 (58.33%), Postives = 84/120 (70.00%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTD-SRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + + EA MNVSEIIK GYP E + V TEDGYILS+ RIP G + SRPVVLLQHGLL + ++SN P SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 40 AADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEM 159
BLAST of Lipase vs. Ensembl Mouse
Match: Lipf (lipase, gastric [Source:MGI Symbol;Acc:MGI:1914967]) HSP 1 Score: 134.035 bits (336), Expect = 6.005e-38 Identity = 64/116 (55.17%), Postives = 83/116 (71.55%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 EA MNVS++I +GYP E + V TEDGYIL + RIPYG KN+ + RPV LQHGL+ S+ +++N P SL FILAD G+DVWL NSRGN +S ++ YS + EFW F++DEM Sbjct: 29 EANMNVSQMITYWGYPSEEYEVVTEDGYILGVYRIPYGKKNSENIGKRPVAYLQHGLIASATNWITNLPNNSLAFILADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFDEM 144
BLAST of Lipase vs. Ensembl Mouse
Match: Lipa (lysosomal acid lipase A [Source:MGI Symbol;Acc:MGI:96789]) HSP 1 Score: 132.494 bits (332), Expect = 2.493e-37 Identity = 67/120 (55.83%), Postives = 82/120 (68.33%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +++ E MNV+EII +GYP E HSV T DGYILS+ RIP G KN RPVV LQHGLL S +V+N SLGF+LAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 26 AVDPEVNMNVTEIIMRWGYPGEEHSVLTGDGYILSIHRIPRGRKNHFGKGPRPVVYLQHGLLADSSNWVTNIDNSSLGFLLADAGFDVWMGNSRGNTWSLKHKTLSVSQDEFWAFSFDEM 145
BLAST of Lipase vs. Ensembl Mouse
Match: Lipa (lysosomal acid lipase A [Source:MGI Symbol;Acc:MGI:96789]) HSP 1 Score: 132.494 bits (332), Expect = 2.493e-37 Identity = 67/120 (55.83%), Postives = 82/120 (68.33%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +++ E MNV+EII +GYP E HSV T DGYILS+ RIP G KN RPVV LQHGLL S +V+N SLGF+LAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 26 AVDPEVNMNVTEIIMRWGYPGEEHSVLTGDGYILSIHRIPRGRKNHFGKGPRPVVYLQHGLLADSSNWVTNIDNSSLGFLLADAGFDVWMGNSRGNTWSLKHKTLSVSQDEFWAFSFDEM 145
BLAST of Lipase vs. Ensembl Mouse
Match: Lipk (lipase, family member K [Source:MGI Symbol;Acc:MGI:2679259]) HSP 1 Score: 131.724 bits (330), Expect = 4.334e-37 Identity = 62/117 (52.99%), Postives = 81/117 (69.23%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRP--VVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 EA MN+SE+I +GYP E H V TEDGYIL RIP+G K S + P VV LQHGL+ S+ ++ N P SL F+LAD+G+DVWL NSRGN +S +H++ S ++W F+WDEM Sbjct: 29 EANMNISELISYWGYPYEKHDVITEDGYILGTYRIPHG-KGCSRKTAPKAVVYLQHGLIASANNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRNHLRLSPKSPQYWAFSWDEM 144
BLAST of Lipase vs. UniProt/SwissProt
Match: sp|Q5VYY2|LIPM_HUMAN (Lipase member M OS=Homo sapiens OX=9606 GN=LIPM PE=2 SV=2) HSP 1 Score: 143.28 bits (360), Expect = 1.723e-40 Identity = 69/120 (57.50%), Postives = 87/120 (72.50%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGL-KNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +++ EA MN+SEII+ GYP E + V TEDGYILS+ RIP GL + T SRPVVLLQHGL+ + ++SN P SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 40 AVDPEAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEM 159
BLAST of Lipase vs. UniProt/SwissProt
Match: sp|Q29458|LIPG_BOVIN (Gastric triacylglycerol lipase OS=Bos taurus OX=9913 GN=LIPF PE=1 SV=1) HSP 1 Score: 140.584 bits (353), Expect = 1.284e-39 Identity = 66/116 (56.90%), Postives = 84/116 (72.41%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTS-TDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 EA MNVS++I +GYP EMH V T DGYIL + RIP+G N + RPVV LQHGLL S+ ++SN P+ SLGF+LAD G+DVWL NSRGN ++ H+ YS + EFW F++DEM Sbjct: 29 EASMNVSQMISYWGYPSEMHKVITADGYILQVYRIPHGKNNANHLGQRPVVFLQHGLLGSATNWISNLPKNSLGFLLADAGYDVWLGNSRGNTWAQEHLYYSPDSPEFWAFSFDEM 144
BLAST of Lipase vs. UniProt/SwissProt
Match: sp|Q8K2A6|LIPM_MOUSE (Lipase member M OS=Mus musculus OX=10090 GN=Lipm PE=2 SV=1) HSP 1 Score: 139.043 bits (349), Expect = 6.812e-39 Identity = 70/120 (58.33%), Postives = 84/120 (70.00%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTD-SRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + + EA MNVSEIIK GYP E + V TEDGYILS+ RIP G + SRPVVLLQHGLL + ++SN P SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 40 AADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEM 159
BLAST of Lipase vs. UniProt/SwissProt
Match: sp|P07098|LIPG_HUMAN (Gastric triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPF PE=1 SV=1) HSP 1 Score: 135.961 bits (341), Expect = 8.024e-38 Identity = 65/116 (56.03%), Postives = 84/116 (72.41%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 E MN+S++I +GYP E + V TEDGYIL + RIPYG KN+ +T RPVV LQHGLL S+ ++SN P SL FILAD G+DVWL NSRGN ++ ++ YS + EFW F++DEM Sbjct: 30 EVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEM 145
BLAST of Lipase vs. UniProt/SwissProt
Match: sp|Q4R4S5|LICH_MACFA (Lysosomal acid lipase/cholesteryl ester hydrolase OS=Macaca fascicularis OX=9541 GN=LIPA PE=2 SV=1) HSP 1 Score: 134.806 bits (338), Expect = 2.152e-37 Identity = 75/148 (50.68%), Postives = 94/148 (63.51%), Query Frame = 3 Query: 33 LDFVGLSFFILFLGNGLLHAEPS------IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS-RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + F+GL ++ L LH+E S + E MNVSEII +G+P E + V TEDGYIL L RIP+G KN S +PVV LQHGLL S +V+N SLGFILAD GFDVW+ NSRGN +S H S ++ EFW F++DEM Sbjct: 3 MRFLGL---VVCLVLWTLHSEASGGKLTAVNPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEM 147
BLAST of Lipase vs. TrEMBL
Match: A0A212CNN2 (Uncharacterized protein (Fragment) OS=Cervus elaphus hippelaphus OX=46360 GN=Celaphus_00008443 PE=4 SV=1) HSP 1 Score: 145.591 bits (366), Expect = 6.458e-41 Identity = 73/137 (53.28%), Postives = 95/137 (69.34%), Query Frame = 3 Query: 57 FILFLG--NGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS--RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 FIL LG +G + S+ EA MN+S+II +GYP E + +TTEDGYILSL RIPYG N+ +S R VV LQHGLL S+ +++SN P SLGF+LAD G+DVW+ NSRG +S H+ N +EFW F++DEM Sbjct: 3 FILILGTTHGAFRKQRSVNPEASMNISQIISYWGYPDEEYDITTEDGYILSLYRIPYGKTNSENNSVQRLVVYLQHGLLTSASSWISNLPNNSLGFLLADAGYDVWMGNSRGTTWSRKHLYLKTNSKEFWAFSFDEM 139
BLAST of Lipase vs. TrEMBL
Match: A0A5N5T4Y3 (Lipase 1 OS=Armadillidium nasatum OX=96803 GN=Lip1 PE=4 SV=1) HSP 1 Score: 144.821 bits (364), Expect = 7.126e-41 Identity = 66/121 (54.55%), Postives = 91/121 (75.21%), Query Frame = 3 Query: 99 SIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSK--NEQEFWDFTWDEM 455 SI + ++ V EII+S+GYP E H VTTEDGYIL L RIPYG+ S ++RPV LLQHGLL SSF ++S+ P+++L ++LAD G+DVWL N+RGN+YS +H +++EFW FT+DE+ Sbjct: 23 SIYDYEELTVPEIIQSFGYPAETHHVTTEDGYILELHRIPYGIDGPSEEARPVALLQHGLLVSSFDWISDRPDRALAYMLADAGYDVWLMNARGNLYSRNHTTLDPDVDKEEFWGFTYDEI 143
BLAST of Lipase vs. TrEMBL
Match: A0A2J7QG21 (Lipase 3 OS=Cryptotermes secundus OX=105785 GN=Lip3_3 PE=4 SV=1) HSP 1 Score: 147.902 bits (372), Expect = 2.028e-40 Identity = 67/130 (51.54%), Postives = 92/130 (70.77%), Query Frame = 3 Query: 81 LLHAEPSIE-----EEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 LL+ PS+E + +N E+I+ YGYP E+H+VTTED YIL++ RIPY K+ + ++PVV LQHG+L SS ++ GPE SLG++LAD GFDVWL N+RGN YS H+ S ++ +FWDF+W EM Sbjct: 51 LLNLIPSLENNNGNPDQYLNTPELIEKYGYPAEIHTVTTEDSYILTVHRIPYSPKSPAAPNKPVVFLQHGILSSSADWIILGPENSLGYLLADAGFDVWLGNARGNTYSKKHLSLSTSDSKFWDFSWHEM 180
BLAST of Lipase vs. TrEMBL
Match: A0A016WCI6 (Abhydro_lipase domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0783.g2328 PE=4 SV=1) HSP 1 Score: 146.362 bits (368), Expect = 2.639e-40 Identity = 70/137 (51.09%), Postives = 89/137 (64.96%), Query Frame = 3 Query: 48 LSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTS-TDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 L F++ L +A + E KM +II+ +GYP E+++VTTEDGYIL L RIPYG + T RPVV +QHGL SS +V+N P++S GFI AD GFDVWL N RGN YS HI S +FW++TWDEM Sbjct: 3 LCSFLVALAAITTYARKHEDPECKMTTPQIIEHWGYPAEIYTVTTEDGYILELHRIPYGKNDAKPTSPRPVVFMQHGLECSSSNWVTNLPDESAGFIFADAGFDVWLGNMRGNTYSTKHINLSPKHDKFWEWTWDEM 139
BLAST of Lipase vs. TrEMBL
Match: A0A5N5T4S5 (Lipase 3 (Fragment) OS=Armadillidium nasatum OX=96803 GN=Lip3_4 PE=4 SV=1) HSP 1 Score: 145.206 bits (365), Expect = 2.659e-40 Identity = 64/114 (56.14%), Postives = 89/114 (78.07%), Query Frame = 3 Query: 120 MNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYS--KNEQEFWDFTWDEM 455 + V EII+S+GYP+E+H VTTEDGYIL L RIPYG+ +S ++RPV LLQHGLL SSF ++S+ P+++L ++LAD G+DVWL N+RGN YS +H +++EFW FT+DE+ Sbjct: 6 LTVPEIIQSFGYPVEIHHVTTEDGYILELHRIPYGIDGSSEEARPVALLQHGLLVSSFDWISDRPDRALAYLLADAGYDVWLMNARGNYYSRNHTTLDPVADKEEFWAFTYDEI 119
BLAST of Lipase vs. Ensembl Cavefish
Match: lipf (lysosomal acid lipase/cholesteryl ester hydrolase-like [Source:NCBI gene;Acc:103040858]) HSP 1 Score: 147.132 bits (370), Expect = 4.313e-43 Identity = 67/120 (55.83%), Postives = 88/120 (73.33%), Query Frame = 3 Query: 102 IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS--RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 ++ E MN+SEII+ +GYP E + V TEDGYILS+ RIPYG+KN + + RPVV LQHGLL + +V+N P SLGF+LAD GFDVWL NSRGN +S H+ S ++ E+W+F+ DEM Sbjct: 26 VDPEVNMNISEIIRYWGYPAEEYEVVTEDGYILSINRIPYGVKNKDSQAAPRPVVFLQHGLLAAGSNWVTNLPNTSLGFVLADAGFDVWLGNSRGNTWSRKHVSLSPDQNEYWEFSHDEM 145
BLAST of Lipase vs. Ensembl Cavefish
Match: lipf (lysosomal acid lipase/cholesteryl ester hydrolase-like [Source:NCBI gene;Acc:103023710]) HSP 1 Score: 146.362 bits (368), Expect = 9.356e-43 Identity = 67/131 (51.15%), Postives = 93/131 (70.99%), Query Frame = 3 Query: 69 LGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKN--TSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 L +G L ++ E MN+SEII+ +GYP E + V TEDGYILS+ RIP+G+KN + D +PVV LQHGLL ++ +V+N P SLG++LAD GFDVWL NSRGN +S H+ S+++ E+W F+ DE+ Sbjct: 15 LAHGWLFWRRRVDPEIHMNISEIIRYWGYPAEEYEVVTEDGYILSINRIPHGIKNQDSRADPKPVVFLQHGLLAAASNWVTNLPNTSLGYLLADAGFDVWLGNSRGNTWSRKHVSLSRDQNEYWRFSRDEL 145
BLAST of Lipase vs. Ensembl Sea Lamprey
Match: lipf (lipase, gastric [Source:ZFIN;Acc:ZDB-GENE-040426-2737]) HSP 1 Score: 128.257 bits (321), Expect = 1.801e-36 Identity = 69/160 (43.12%), Postives = 96/160 (60.00%), Query Frame = 3 Query: 6 ILFNFMKRNLDFVGLSFFILFLGNGLL--------HAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTS--TDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 + F ++ + V L +L G G + H + + E MN+SE+I S GYP + V T DG+ILS+ RIP GLK+ + T RP VLLQHGLL +VSN SLGFILAD G+DVW+ NSRGN +S+ H + +++EFW +++DEM Sbjct: 1 LCFVLIRNMVLIVALHVTLLLFGVGFVSGRMLPDQHNDLRSDPEIYMNISELISSKGYPNVEYKVETADGFILSVNRIPRGLKDNTAGTAVRPAVLLQHGLLAGGSNWVSNFAHDSLGFILADAGYDVWIGNSRGNTWSHHHRTLTPDQEEFWAWSYDEM 160
BLAST of Lipase vs. Ensembl Sea Lamprey
Match: lipf (lipase, gastric [Source:ZFIN;Acc:ZDB-GENE-040426-2737]) HSP 1 Score: 117.857 bits (294), Expect = 1.586e-33 Identity = 59/120 (49.17%), Postives = 80/120 (66.67%), Query Frame = 3 Query: 84 LHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFT 443 +H + + E MN+SE+I S GYP + V T DG+ILS+ RIP GLK+++ RP VLLQHGLL +VSN SLGFILAD G+DVW+ NSRGN S+ H + +++EFW ++ Sbjct: 15 VHNDLRSDPEMYMNISELISSKGYPNVEYKVETADGFILSVNRIPRGLKHSTAAVRPAVLLQHGLLAGGSNWVSNFAHDSLGFILADAGYDVWIGNSRGNT-SHHHRALTPDQEEFWAWS 133
BLAST of Lipase vs. Ensembl Yeast
Match: TGL1 (Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes [Source:SGD;Acc:S000001623]) HSP 1 Score: 86.6557 bits (213), Expect = 4.191e-21 Identity = 50/121 (41.32%), Postives = 69/121 (57.02%), Query Frame = 3 Query: 99 SIEEEAKM--NVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSN-GPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDE 452 +IEE+ + + E+ + +E H V TED YIL+L RIP KN + VV L HGLL S + N K+L F+L D G+DVW+ N+RGN YS +H+ +FWDF+ DE Sbjct: 55 TIEEKLRSAPTIHEMCAIFDISVEDHLVRTEDNYILTLHRIPPISKNRFNNK--VVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLGYDVWMGNNRGNKYSTAHLNKPPKSNKFWDFSIDE 173
BLAST of Lipase vs. Ensembl Yeast
Match: YEH1 (Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication [Source:SGD;Acc:S000003935]) HSP 1 Score: 60.4622 bits (145), Expect = 5.245e-12 Identity = 31/80 (38.75%), Postives = 48/80 (60.00%), Query Frame = 3 Query: 144 SYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS--RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSR 377 Y +E + TEDG+++ L + + T +D RP +L+ HGLL SS ++ SNG KSL + L +G+D+WL N+R Sbjct: 184 QYNIQIEEFRLETEDGFVIDLWHLIPKYRTTDSDKKKRPPILMLHGLLQSSGSFASNG-RKSLAYFLYQSGYDIWLGNNR 262
BLAST of Lipase vs. Ensembl Yeast
Match: YEH2 (Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication [Source:SGD;Acc:S000004010]) HSP 1 Score: 60.077 bits (144), Expect = 6.985e-12 Identity = 38/107 (35.51%), Postives = 59/107 (55.14%), Query Frame = 3 Query: 141 KSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTD-SRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQ-EFWDFTWDEM 455 K YG +E V T+DG+I+ L L + + R +LL HGLL S + S+G KSL + L ++GFDVWL N+R + + ++K N+ + WD+ +M Sbjct: 155 KEYGIDIEEFEVETDDGFIIDLWHFKSRLNDGVEEVKREPILLLHGLLQSCGAFASSG-RKSLAYFLYESGFDVWLGNNRCGLNAKWNMKKLGNDHSKKWDWDMHQM 260
BLAST of Lipase vs. Ensembl Nematostella
Match: EDO38398 (Lipase [Source:UniProtKB/TrEMBL;Acc:A7SCY7]) HSP 1 Score: 138.272 bits (347), Expect = 5.122e-40 Identity = 70/146 (47.95%), Postives = 94/146 (64.38%), Query Frame = 3 Query: 42 VGLSFFILFLGNGLLH-----AEPS---IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNT-STDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDE 452 V ++ LGN L P ++ + NVS++I + G+P+E H V T+DGYILS+QRIP+G K S RPVV LQHGLL S +V + SLG+ILADNG+DVWL N RGN YS SH+KY+ ++EFWDF+++E Sbjct: 3 VSFCLLVVLLGNQLCCLLAKGTRPKWGPVDPDVNRNVSQLIHNRGFPVEEHDVITKDGYILSVQRIPHGRKGRESPGPRPVVFLQHGLLADSSCFVQSWEYDSLGYILADNGYDVWLGNIRGNRYSRSHVKYNHKQREFWDFSFEE 148
BLAST of Lipase vs. Ensembl Nematostella
Match: EDO40744 (Lipase [Source:UniProtKB/TrEMBL;Acc:A7S6G4]) HSP 1 Score: 138.272 bits (347), Expect = 6.841e-40 Identity = 65/123 (52.85%), Postives = 86/123 (69.92%), Query Frame = 3 Query: 93 EPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDS--RPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 EP + + N S++I++ GYP+E H VTT DG+IL+LQRIP+G S +PVV LQHGLL S +V N P SLG+ILAD GFDVWL N RGN YS +H+K++K+ +FWD+TW +M Sbjct: 27 EPPRDPDIDRNASQLIRNRGYPVEEHYVTTSDGFILNLQRIPHGRNELREGSGRKPVVFLQHGLLMDSTNWVLNSPHDSLGYILADKGFDVWLGNIRGNEYSAAHVKWNKDSSKFWDWTWQQM 149
BLAST of Lipase vs. Ensembl Nematostella
Match: EDO41646 (Lipase [Source:UniProtKB/TrEMBL;Acc:A7S3Q1]) HSP 1 Score: 137.117 bits (344), Expect = 7.503e-40 Identity = 63/118 (53.39%), Postives = 84/118 (71.19%), Query Frame = 3 Query: 105 EEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTD--SRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDE 452 + E MNVS++I+ +GYP+E + V T+DGYI+S+QRIP+G D ++PV+ +QHGLL SS +V+N P +SL FILADN FDVWL N RGNIY H+ S + FWDF+WDE Sbjct: 5 DPEINMNVSQMIQYHGYPVENYDVITKDGYIISIQRIPFGQNGKCKDVPNKPVIFVQHGLLCSSTNWVANLPNESLAFILADNCFDVWLGNVRGNIYGMRHVNVSIHSDAFWDFSWDE 122
BLAST of Lipase vs. Ensembl Nematostella
Match: EDO35549 (Lipase [Source:UniProtKB/TrEMBL;Acc:A7SL62]) HSP 1 Score: 132.88 bits (333), Expect = 7.682e-38 Identity = 64/117 (54.70%), Postives = 80/117 (68.38%), Query Frame = 3 Query: 111 EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGL--KNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 E MNV+++I+ GYP+E + VTTEDGYILS+QRIPYG K +PVV LQHGLL S+ +V+N +S GFILAD FDVWL N RGN Y H+K + FWDF++DEM Sbjct: 46 EVHMNVTQLIQYNGYPVEDYDVTTEDGYILSVQRIPYGREGKCKGVKDKPVVFLQHGLLCSATNWVTNLYNESFGFILADQCFDVWLGNVRGNTYGKRHVKLPVDSDAFWDFSFDEM 162
BLAST of Lipase vs. Ensembl Nematostella
Match: EDO29518 (Lipase [Source:UniProtKB/TrEMBL;Acc:A7T3E6]) HSP 1 Score: 129.028 bits (323), Expect = 1.324e-36 Identity = 65/129 (50.39%), Postives = 84/129 (65.12%), Query Frame = 3 Query: 75 NGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGL--KNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 N LL + ++ E M +++I+ GYP+E + VTTEDGYILS+QRIPYG K +PVV LQHGLL S+ +V+N +S GFILAD FDVWL N RGN Y H+K + FWDF++DEM Sbjct: 8 NCLL--QKCLKPETNMIFTQLIQYNGYPVEDYDVTTEDGYILSVQRIPYGREGKCKGVKDKPVVFLQHGLLCSATNWVTNLYNESFGFILADQCFDVWLGNVRGNTYGKRHVKLPVDSDAFWDFSFDEM 134
BLAST of Lipase vs. Ensembl Medaka
Match: lipf (lysosomal acid lipase/cholesteryl ester hydrolase-like [Source:NCBI gene;Acc:101156001]) HSP 1 Score: 143.665 bits (361), Expect = 1.305e-41 Identity = 64/118 (54.24%), Postives = 86/118 (72.88%), Query Frame = 3 Query: 102 IEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 ++ E MN+SEII+ +GYP E H V TEDGYILS+ RIP GLK T+ +P VLLQHGLL + +V+N P SLGF+LAD G+DVW+ NSRGN +S H + ++++FW F++DEM Sbjct: 36 LDPEVNMNISEIIRRWGYPAEEHEVVTEDGYILSVNRIPSGLKRTA-GPKPAVLLQHGLLAAGSNWVTNPPSSSLGFVLADAGYDVWIGNSRGNTWSKRHRTLTPDQEDFWKFSYDEM 152
BLAST of Lipase vs. Ensembl Medaka
Match: lipf (lysosomal acid lipase/cholesteryl ester hydrolase-like [Source:NCBI gene;Acc:101156001]) HSP 1 Score: 135.191 bits (339), Expect = 1.634e-38 Identity = 61/109 (55.96%), Postives = 80/109 (73.39%), Query Frame = 3 Query: 129 SEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 SEII+ +GYP E H V TEDGYILS+ RIP GLK T+ +P VLLQHGLL + +V+N P SLGF+LAD G+DVW+ NSRGN +S H + ++++FW F++DEM Sbjct: 34 SEIIRRWGYPAEEHEVVTEDGYILSVNRIPSGLKRTA-GPKPAVLLQHGLLAAGSNWVTNPPSSSLGFVLADAGYDVWIGNSRGNTWSKRHRTLTPDQEDFWKFSYDEM 141
BLAST of Lipase vs. Ensembl Medaka
Match: lipf (lysosomal acid lipase/cholesteryl ester hydrolase-like [Source:NCBI gene;Acc:101156001]) HSP 1 Score: 133.265 bits (334), Expect = 4.961e-38 Identity = 60/108 (55.56%), Postives = 79/108 (73.15%), Query Frame = 3 Query: 132 EIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 EII+ +GYP E H V TEDGYILS+ RIP GLK T+ +P VLLQHGLL + +V+N P SLGF+LAD G+DVW+ NSRGN +S H + ++++FW F++DEM Sbjct: 10 EIIRRWGYPAEEHEVVTEDGYILSVNRIPSGLKRTA-GPKPAVLLQHGLLAAGSNWVTNPPSSSLGFVLADAGYDVWIGNSRGNTWSKRHRTLTPDQEDFWKFSYDEM 116
BLAST of Lipase vs. Planmine SMEST
Match: SMESG000055087.1 (SMESG000055087.1) HSP 1 Score: 299.286 bits (765), Expect = 1.239e-105 Identity = 145/145 (100.00%), Postives = 145/145 (100.00%), Query Frame = 3 Query: 21 MKRNLDFVGLSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 MKRNLDFVGLSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM Sbjct: 1 MKRNLDFVGLSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 145
BLAST of Lipase vs. Planmine SMEST
Match: SMESG000074186.1 (SMESG000074186.1) HSP 1 Score: 195.667 bits (496), Expect = 5.956e-62 Identity = 94/143 (65.73%), Postives = 114/143 (79.72%), Query Frame = 3 Query: 48 LSFFILF------LGNGLLHAEPSIEE-EAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 +S ++LF L G L P+ ++ E KMNV+EII Y YP E H VTTEDGYILSLQRIP+GLKN S SRPVV LQHGL+DSSFT+V+NGP+KSLGF+LAD GFDVWLSN+RGN+YSNSHIKY+ +++ FWDFTWD+M Sbjct: 1 MSIYLLFIEYFISLSVGQLQPPPASQDSEIKMNVTEIILYYNYPCENHLVTTEDGYILSLQRIPFGLKNNSLQSRPVVFLQHGLVDSSFTWVANGPDKSLGFVLADKGFDVWLSNTRGNVYSNSHIKYTTSDRNFWDFTWDDM 143
BLAST of Lipase vs. Planmine SMEST
Match: SMESG000007797.1 (SMESG000007797.1) HSP 1 Score: 185.652 bits (470), Expect = 4.415e-58 Identity = 86/131 (65.65%), Postives = 104/131 (79.39%), Query Frame = 3 Query: 63 LFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 LF+ N L H + + E MNV+E+I Y YP E H VTTEDGYILS+QRIP+G+K +S+ RPVV LQHGLLDSSFT+V+N P+KSL FILADNGFDVWL+NSRGN+YSN HIKY + +FWDF+WDEM Sbjct: 12 LFITNALSHKYET-DPEIYMNVTEVINLYKYPCENHLVTTEDGYILSMQRIPFGIKMSSSSKRPVVFLQHGLLDSSFTWVNNAPDKSLAFILADNGFDVWLANSRGNVYSNKHIKYPTDSNKFWDFSWDEM 141
BLAST of Lipase vs. Planmine SMEST
Match: SMESG000007797.1 (SMESG000007797.1) HSP 1 Score: 185.652 bits (470), Expect = 4.705e-58 Identity = 86/131 (65.65%), Postives = 104/131 (79.39%), Query Frame = 3 Query: 63 LFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 LF+ N L H + + E MNV+E+I Y YP E H VTTEDGYILS+QRIP+G+K +S+ RPVV LQHGLLDSSFT+V+N P+KSL FILADNGFDVWL+NSRGN+YSN HIKY + +FWDF+WDEM Sbjct: 16 LFITNALSHKYET-DPEIYMNVTEVINLYKYPCENHLVTTEDGYILSMQRIPFGIKMSSSSKRPVVFLQHGLLDSSFTWVNNAPDKSLAFILADNGFDVWLANSRGNVYSNKHIKYPTDSNKFWDFSWDEM 145
BLAST of Lipase vs. Planmine SMEST
Match: SMESG000074187.1 (SMESG000074187.1) HSP 1 Score: 179.489 bits (454), Expect = 1.269e-55 Identity = 84/135 (62.22%), Postives = 99/135 (73.33%), Query Frame = 3 Query: 51 SFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGYPLEMHSVTTEDGYILSLQRIPYGLKNTSTDSRPVVLLQHGLLDSSFTYVSNGPEKSLGFILADNGFDVWLSNSRGNIYSNSHIKYSKNEQEFWDFTWDEM 455 I+ + GLL + E M+V+E+IK YGYPLE H VTTEDGYIL++QRIPYG ++ +PVV LQHGLLDSSFT+V+NGPEKSL FILAD GFDVWL NSRGN YS H K+S + FWDFTWDEM Sbjct: 11 CLLIVSINGGLLSPGIETDPEVTMDVNEVIKYYGYPLETHQVTTEDGYILTMQRIPYGRTSSPGIKKPVVFLQHGLLDSSFTWVNNGPEKSLAFILADRGFDVWLGNSRGNTYSRKHTKFSPFSKFFWDFTWDEM 145 The following BLAST results are available for this feature:
BLAST of Lipase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Lipase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Lipase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Lipase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of Lipase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Lipase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Lipase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Lipase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Lipase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Lipase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Lipase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 3
BLAST of Lipase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Lipase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of Lipase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002769 ID=SMED30002769|Name=Lipase|organism=Schmidtea mediterranea sexual|type=transcript|length=455bpback to top protein sequence of SMED30002769-orf-1 >SMED30002769-orf-1 ID=SMED30002769-orf-1|Name=SMED30002769-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=151bp EILFNFMKRNLDFVGLSFFILFLGNGLLHAEPSIEEEAKMNVSEIIKSYGback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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