Dual specificity tyrosine-phosphorylation-regulated kinase 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002728 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 615.15 bits (1585), Expect = 0.000e+0 Identity = 293/469 (62.47%), Postives = 352/469 (75.05%), Query Frame = 2
Query: 317 YRESDNKNVFLDT-----SQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ ++ NK L T + + G PVV L DS +Q +S SM G + P+ E AMK YM KLT+FEHHEIFSYPEIYF+G NAKKR G+ GG +N GYDD+Q SYV V HDH+AYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD + N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L++ SKRAK F++S+GYPRYC + +DG ++L G RS+RGK RGPP ++ + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 94 FEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQL---------DSIHRRQGSSTSLKSMEG-------------MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP 540
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 613.609 bits (1581), Expect = 0.000e+0 Identity = 293/469 (62.47%), Postives = 352/469 (75.05%), Query Frame = 2
Query: 317 YRESDNKNVFLDT-----SQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ ++ NK L T + + G PVV L DS +Q +S SM G + P+ E AMK YM KLT+FEHHEIFSYPEIYF+G NAKKR G+ GG +N GYDD+Q SYV V HDH+AYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD + N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L++ SKRAK F++S+GYPRYC + +DG ++L G RS+RGK RGPP ++ + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 21 FEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQL---------DSIHRRQGSSTSLKSMEG-------------MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP 467
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 276/448 (61.61%), Postives = 337/448 (75.22%), Query Frame = 2
Query: 413 RTKNMVDSKPLKQS-RGSSTISMTASFTKDSLTNVSRRAGSYEKN--PINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVD 1747
R N + S + S + S T+S S D L V + S P+ E A+K Y + LT++E EI +YPEIYFVG NAKKR+GV+GG +N GYDD +Y++V DH+AYR+EV+KI+GKGSFGQV + YDHK YVALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNHVCM FELL+I+LYELIKKNKFQGFS+QLVRKFA SIL LD LH+NK+IHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILGS Y+ ID+WSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP L+E SKRAK FINS+G PRYC++ DG ++L G RS+RGK RGPPG+K + LK C D+ F+ FLKRCL W P R+TP +AL+ W+ + P P T +D
Sbjct: 75 RKSNTIQSDGISDSEKCSPTVSQGKS--SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR------PLTTID 514
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 276/448 (61.61%), Postives = 337/448 (75.22%), Query Frame = 2
Query: 413 RTKNMVDSKPLKQS-RGSSTISMTASFTKDSLTNVSRRAGSYEKN--PINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVD 1747
R N + S + S + S T+S S D L V + S P+ E A+K Y + LT++E EI +YPEIYFVG NAKKR+GV+GG +N GYDD +Y++V DH+AYR+EV+KI+GKGSFGQV + YDHK YVALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNHVCM FELL+I+LYELIKKNKFQGFS+QLVRKFA SIL LD LH+NK+IHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILGS Y+ ID+WSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP L+E SKRAK FINS+G PRYC++ DG ++L G RS+RGK RGPPG+K + LK C D+ F+ FLKRCL W P R+TP +AL+ W+ + P P T +D
Sbjct: 75 RKSNTIQSDGISDSEKCSPTVSQGKS--SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR------PLTTID 514
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 276/448 (61.61%), Postives = 337/448 (75.22%), Query Frame = 2
Query: 413 RTKNMVDSKPLKQS-RGSSTISMTASFTKDSLTNVSRRAGSYEKN--PINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVD 1747
R N + S + S + S T+S S D L V + S P+ E A+K Y + LT++E EI +YPEIYFVG NAKKR+GV+GG +N GYDD +Y++V DH+AYR+EV+KI+GKGSFGQV + YDHK YVALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNHVCM FELL+I+LYELIKKNKFQGFS+QLVRKFA SIL LD LH+NK+IHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILGS Y+ ID+WSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP L+E SKRAK FINS+G PRYC++ DG ++L G RS+RGK RGPPG+K + LK C D+ F+ FLKRCL W P R+TP +AL+ W+ + P P T +D
Sbjct: 95 RKSNTIQSDGISDSEKCSPTVSQGKS--SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR------PLTTID 534
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 578.941 bits (1491), Expect = 0.000e+0 Identity = 270/419 (64.44%), Postives = 326/419 (77.80%), Query Frame = 2
Query: 557 ETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIGVHENFLM 1813
E A++ + KL FE +EI++Y ++FVG +AKK+ GV+GG +N GYDDE SY V HDHIAYR+EV+K++GKGSFGQV+KA+DHKY YVALK++RNEKRF RQA EEIRIL++L++QD HNI+H+L+ F FRNH C+TFELL+INLYELIK+NKFQGFSL LVRKFA+S+LLCLDLL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC++ QRIYTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLA IIELLG+PP +E +KRA+ FI S+GYPRYC DG ++L G RSKRGK RGPP ++S + LKN D FV FLKRCL W P+ RMTP +ALK +WLRR+ PN +D S D K+T T I + N LM
Sbjct: 396 EDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLADH-EKKTETLPNIDSNANILM 813
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0 Identity = 270/419 (64.44%), Postives = 326/419 (77.80%), Query Frame = 2
Query: 557 ETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIGVHENFLM 1813
E A++ + KL FE +EI++Y ++FVG +AKK+ GV+GG +N GYDDE SY V HDHIAYR+EV+K++GKGSFGQV+KA+DHKY YVALK++RNEKRF RQA EEIRIL++L++QD HNI+H+L+ F FRNH C+TFELL+INLYELIK+NKFQGFSL LVRKFA+S+LLCLDLL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC++ QRIYTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLA IIELLG+PP +E +KRA+ FI S+GYPRYC DG ++L G RSKRGK RGPP ++S + LKN D FV FLKRCL W P+ RMTP +ALK +WLRR+ PN +D S D K+T T I + N LM
Sbjct: 379 EDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLADH-EKKTETLPNIDSNANILM 796
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0 Identity = 263/399 (65.91%), Postives = 317/399 (79.45%), Query Frame = 2
Query: 557 ETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGD 1753
E A++ + KL FE +EI++Y ++FVG +AKK+ GV+GG +N GYDDE SY V HDHIAYR+EV+K++GKGSFGQV+KA+DHKY YVALK++RNEKRF RQA EEIRIL++L++QD HNI+H+L+ F FRNH C+TFELL+INLYELIK+NKFQGFSL LVRKFA+S+LLCLDLL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC++ QRIYTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLA IIELLG+PP +E +KRA+ FI S+GYPRYC DG ++L G RSKRGK RGPP ++S + LKN D FV FLKRCL W P+ RMTP +ALK +WLRR+ PN +D S D
Sbjct: 379 EDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLAD 777
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0 Identity = 263/399 (65.91%), Postives = 317/399 (79.45%), Query Frame = 2
Query: 557 ETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGD 1753
E A++ + KL FE +EI++Y ++FVG +AKK+ GV+GG +N GYDDE SY V HDHIAYR+EV+K++GKGSFGQV+KA+DHKY YVALK++RNEKRF RQA EEIRIL++L++QD HNI+H+L+ F FRNH C+TFELL+INLYELIK+NKFQGFSL LVRKFA+S+LLCLDLL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC++ QRIYTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLA IIELLG+PP +E +KRA+ FI S+GYPRYC DG ++L G RSKRGK RGPP ++S + LKN D FV FLKRCL W P+ RMTP +ALK +WLRR+ PN +D S D
Sbjct: 396 EDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLAD 794
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 573.548 bits (1477), Expect = 0.000e+0 Identity = 270/419 (64.44%), Postives = 326/419 (77.80%), Query Frame = 2
Query: 557 ETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIGVHENFLM 1813
E A++ + KL FE +EI++Y ++FVG +AKK+ GV+GG +N GYDDE SY V HDHIAYR+EV+K++GKGSFGQV+KA+DHKY YVALK++RNEKRF RQA EEIRIL++L++QD HNI+H+L+ F FRNH C+TFELL+INLYELIK+NKFQGFSL LVRKFA+S+LLCLDLL +N++IHCDLKPEN+LLKQQGRSGIKVIDFGSSC++ QRIYTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLA IIELLG+PP +E +KRA+ FI S+GYPRYC DG ++L G RSKRGK RGPP ++S + LKN D FV FLKRCL W P+ RMTP +ALK +WLRR+ PN +D S D K+T T I + N LM
Sbjct: 114 EDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLADH-EKKTETLPNIDSNANILM 531
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100406) HSP 1 Score: 530.02 bits (1364), Expect = 2.931e-178 Identity = 246/387 (63.57%), Postives = 313/387 (80.88%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
++ + M LYMNKLT +E EI +YP+IYF+G NAKKR GV G +N YD+EQ +Y++V HDH+AYR+E++KI+GKGSFGQV+KAYDHK + +VALK++RNEKRF RQA EEIRIL +L++ D + NI+H+ + FTFRNH C+TFELL+INLYELIKKN F+GFSLQLVRKFAHS+L CLD L++N +IHCD+KPEN+LLKQQGRSGIKVIDFGSSC+E+QRIYTYIQSRFYRAPEVILG Y IDMWS GCILAEL +G LFPGE+E+DQLACIIE+LG+P K+++ +SKR+K F + +GYPRYC + +DG ++L G +S+RGK RGPP +KS+ L C D F++F++ CL+W R+TP EALK WLRR+ P
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYG-PNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLP 594
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100404) HSP 1 Score: 530.02 bits (1364), Expect = 2.931e-178 Identity = 246/387 (63.57%), Postives = 313/387 (80.88%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
++ + M LYMNKLT +E EI +YP+IYF+G NAKKR GV G +N YD+EQ +Y++V HDH+AYR+E++KI+GKGSFGQV+KAYDHK + +VALK++RNEKRF RQA EEIRIL +L++ D + NI+H+ + FTFRNH C+TFELL+INLYELIKKN F+GFSLQLVRKFAHS+L CLD L++N +IHCD+KPEN+LLKQQGRSGIKVIDFGSSC+E+QRIYTYIQSRFYRAPEVILG Y IDMWS GCILAEL +G LFPGE+E+DQLACIIE+LG+P K+++ +SKR+K F + +GYPRYC + +DG ++L G +S+RGK RGPP +KS+ L C D F++F++ CL+W R+TP EALK WLRR+ P
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYG-PNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLP 594
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100402) HSP 1 Score: 530.02 bits (1364), Expect = 2.931e-178 Identity = 246/387 (63.57%), Postives = 313/387 (80.88%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
++ + M LYMNKLT +E EI +YP+IYF+G NAKKR GV G +N YD+EQ +Y++V HDH+AYR+E++KI+GKGSFGQV+KAYDHK + +VALK++RNEKRF RQA EEIRIL +L++ D + NI+H+ + FTFRNH C+TFELL+INLYELIKKN F+GFSLQLVRKFAHS+L CLD L++N +IHCD+KPEN+LLKQQGRSGIKVIDFGSSC+E+QRIYTYIQSRFYRAPEVILG Y IDMWS GCILAEL +G LFPGE+E+DQLACIIE+LG+P K+++ +SKR+K F + +GYPRYC + +DG ++L G +S+RGK RGPP +KS+ L C D F++F++ CL+W R+TP EALK WLRR+ P
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYG-PNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLP 594
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0100447) HSP 1 Score: 429.098 bits (1102), Expect = 1.699e-140 Identity = 200/388 (51.55%), Postives = 276/388 (71.13%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRY---GVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLR 1696
P+ +K + N LT E E+ Y E+++ GQ+A K Y T N GYDD+ +Y + HDHIA+R+E+++++GKGSFGQV++A DHK N +VA+K+IRN+KRF QA E+ IL+ L+++D +HN++H+L+ FR H+C+TFEL+++NLYELIKKN + GFS+ L+R+F +SI+ CL LL++ +IHCDLKPENILLKQ+G S IKVIDFGSSCY ++IYTYIQSRFYR+PEVILG Y IDMWS GCILAEL+TG PLFPGE+E +QLACI+E+LG+PPK LI ++R ++F +SR PR + +G+ R PG+KS+ +L +C D F+ FL+RCL+W P +RMTP EA E+L+
Sbjct: 125 TPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCIT---------------NTKGRKRS-PGSKSLAHIL-HCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089289) HSP 1 Score: 429.098 bits (1102), Expect = 1.699e-140 Identity = 200/388 (51.55%), Postives = 276/388 (71.13%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRY---GVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLR 1696
P+ +K + N LT E E+ Y E+++ GQ+A K Y T N GYDD+ +Y + HDHIA+R+E+++++GKGSFGQV++A DHK N +VA+K+IRN+KRF QA E+ IL+ L+++D +HN++H+L+ FR H+C+TFEL+++NLYELIKKN + GFS+ L+R+F +SI+ CL LL++ +IHCDLKPENILLKQ+G S IKVIDFGSSCY ++IYTYIQSRFYR+PEVILG Y IDMWS GCILAEL+TG PLFPGE+E +QLACI+E+LG+PPK LI ++R ++F +SR PR + +G+ R PG+KS+ +L +C D F+ FL+RCL+W P +RMTP EA E+L+
Sbjct: 125 TPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCIT---------------NTKGRKRS-PGSKSLAHIL-HCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 593.578 bits (1529), Expect = 0.000e+0 Identity = 277/405 (68.40%), Postives = 335/405 (82.72%), Query Frame = 2
Query: 494 KDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ S T++ + P+ E AMK YM+KL+ FEH EI SY EIYF+G NAKKR GV+GG++N GYDD+Q SY++V HDHIAYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD S N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CL+ LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IE+LG+P + L+E+SKRAK FI+S+G+PRYC + D ++L G RS+RGK RGPPG++ V+ LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 123 QGSSTSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRLP 527
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0 Identity = 277/405 (68.40%), Postives = 335/405 (82.72%), Query Frame = 2
Query: 494 KDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ S T++ + P+ E AMK YM+KL+ FEH EI SY EIYF+G NAKKR GV+GG++N GYDD+Q SY++V HDHIAYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD S N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CL+ LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IE+LG+P + L+E+SKRAK FI+S+G+PRYC + D ++L G RS+RGK RGPPG++ V+ LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 113 QGSSTSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRLP 517
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 591.652 bits (1524), Expect = 0.000e+0 Identity = 277/405 (68.40%), Postives = 335/405 (82.72%), Query Frame = 2
Query: 494 KDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ S T++ + P+ E AMK YM+KL+ FEH EI SY EIYF+G NAKKR GV+GG++N GYDD+Q SY++V HDHIAYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD S N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CL+ LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IE+LG+P + L+E+SKRAK FI+S+G+PRYC + D ++L G RS+RGK RGPPG++ V+ LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 134 QGSSTSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRLP 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0 Identity = 262/389 (67.35%), Postives = 322/389 (82.78%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+P+ E A+K + ++T+ E EI +Y EIYF+G NAKKR V GGT+N GYDD+Q Y++V HDH+AYR+E +K++GKGSFGQV K YDHK +VALK++RNEKRF RQAAEEIRILE+LKKQD + + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ LHR+K+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP L+E +KRAK FI+S+G+PRYC + ++G I+L G+RS+RGK RG PG+K + LK C D +F+ FLK+CL W P RMTP +AL+ WL ++ P
Sbjct: 131 SPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVSTLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLP 519
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 582.408 bits (1500), Expect = 0.000e+0 Identity = 262/389 (67.35%), Postives = 322/389 (82.78%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+P+ E A+K + ++T+ E EI +Y EIYF+G NAKKR V GGT+N GYDD+Q Y++V HDH+AYR+E +K++GKGSFGQV K YDHK +VALK++RNEKRF RQAAEEIRILE+LKKQD + + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ LHR+K+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP L+E +KRAK FI+S+G+PRYC + ++G I+L G+RS+RGK RG PG+K + LK C D +F+ FLK+CL W P RMTP +AL+ WL ++ P
Sbjct: 130 SPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVSTLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLP 518
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:100485120]) HSP 1 Score: 613.994 bits (1582), Expect = 0.000e+0 Identity = 286/429 (66.67%), Postives = 341/429 (79.49%), Query Frame = 2
Query: 458 GSSTISMTASFTKDSLTNVSRRAGS------------YEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
G ST+ + + + L + RR GS + + + E AMK YM KLT+FEHHEIF+YPEIYF+G NAKKR GV+GG +N GYDD+Q SYV V HDH+AYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+LKKQD +N N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L++ SKR K F +S+GYPRYC + DG ++L G RS+RGK RGPPG++ V+ LK C D F+ FL +CL+W P RMTP +AL+ WLRR+ P
Sbjct: 139 GKSTLPVVS---ERQLESTHRRQGSSSSLKSAEGITKLKSSSLTPEQAMKQYMQKLTAFEHHEIFNYPEIYFLGPNAKKRQGVIGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRRLP 564
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 565.074 bits (1455), Expect = 0.000e+0 Identity = 270/415 (65.06%), Postives = 330/415 (79.52%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIG 1792
+ + A+K Y ++L+++E EI S+ EIYFVG NAKKR GV+GG +N GYDD+Q Y V HDH+AYR+EV+K++GKGSFGQV K YDHK + ++ALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNH+CMTFELL++NLYELIK+NKFQGFSLQLVRKFAHSIL CL+ L+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCIL EL TG PLFPGEDE DQLAC++ELLG PP L+E +KRAK FINS+GYPRYC + +G +L G+RS+RGK RG PG+K V+ LK C D F+ FLK CL W P RMTP +AL+ +W+ ++ P S + G I +T++ IG
Sbjct: 122 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSV----TEKASGKRISSQTSSFPGIG 532
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 565.074 bits (1455), Expect = 0.000e+0 Identity = 270/415 (65.06%), Postives = 330/415 (79.52%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIG 1792
+ + A+K Y ++L+++E EI S+ EIYFVG NAKKR GV+GG +N GYDD+Q Y V HDH+AYR+EV+K++GKGSFGQV K YDHK + ++ALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNH+CMTFELL++NLYELIK+NKFQGFSLQLVRKFAHSIL CL+ L+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCIL EL TG PLFPGEDE DQLAC++ELLG PP L+E +KRAK FINS+GYPRYC + +G +L G+RS+RGK RG PG+K V+ LK C D F+ FLK CL W P RMTP +AL+ +W+ ++ P S + G I +T++ IG
Sbjct: 100 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSV----TEKASGKRISSQTSSFPGIG 510
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 563.918 bits (1452), Expect = 0.000e+0 Identity = 270/415 (65.06%), Postives = 330/415 (79.52%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIG 1792
+ + A+K Y ++L+++E EI S+ EIYFVG NAKKR GV+GG +N GYDD+Q Y V HDH+AYR+EV+K++GKGSFGQV K YDHK + ++ALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNH+CMTFELL++NLYELIK+NKFQGFSLQLVRKFAHSIL CL+ L+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCIL EL TG PLFPGEDE DQLAC++ELLG PP L+E +KRAK FINS+GYPRYC + +G +L G+RS+RGK RG PG+K V+ LK C D F+ FLK CL W P RMTP +AL+ +W+ ++ P S + G I +T++ IG
Sbjct: 93 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSV----TEKASGKRISSQTSSFPGIG 503
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 563.918 bits (1452), Expect = 0.000e+0 Identity = 270/415 (65.06%), Postives = 330/415 (79.52%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIG 1792
+ + A+K Y ++L+++E EI S+ EIYFVG NAKKR GV+GG +N GYDD+Q Y V HDH+AYR+EV+K++GKGSFGQV K YDHK + ++ALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNH+CMTFELL++NLYELIK+NKFQGFSLQLVRKFAHSIL CL+ L+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCIL EL TG PLFPGEDE DQLAC++ELLG PP L+E +KRAK FINS+GYPRYC + +G +L G+RS+RGK RG PG+K V+ LK C D F+ FLK CL W P RMTP +AL+ +W+ ++ P S + G I +T++ IG
Sbjct: 83 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSV----TEKASGKRISSQTSSFPGIG 493
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:MGI Symbol;Acc:MGI:1330301]) HSP 1 Score: 614.379 bits (1583), Expect = 0.000e+0 Identity = 285/434 (65.67%), Postives = 343/434 (79.03%), Query Frame = 2
Query: 449 QSRGSSTISMTA--SFTKDSLTNVSRRAGS------------YEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
Q G +T+ T + L ++ RR GS + +P+ E AMK YM KLT+FEHHEIFSYPEIYF+G NAKKR G+ GG +N GYDD+Q SYV V HDH+AYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD + N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRS IKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L++ SKRAK F++S+GYPRYC + +DG ++L G RS+RGK RGPP ++ + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 105 QPNGLTTVGKTGLPGVPERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:MGI Symbol;Acc:MGI:1330300]) HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0 Identity = 276/445 (62.02%), Postives = 335/445 (75.28%), Query Frame = 2
Query: 413 RTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNH-SQDNCPSTAV 1744
R N + S + S SS S S S + + + P+ E A+K Y + LT++E EI SYPEIYFVG NAKKR GV+GG +N GYDD +Y++V DH+AYR+EV+KI+GKGSFGQV + YDHK YVALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNHVCM FELL+I+LYELIKKNKFQGFS+QLVRKFA SIL LD LH+NK+IHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILG Y+ ID+WSFGCILAEL TG PLFPGEDE DQLAC+IELLG+PP+ L+E SKRAK FINS+G PRYC++ TDG ++L G RS+RGK RGPPG+K + LK C D+ F+ FLKRCLQW P R+TP +AL+ W+ + P + D P V
Sbjct: 95 RRSNTLQSDGISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTMDKVPGKRV 539
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:MGI Symbol;Acc:MGI:1330292]) HSP 1 Score: 437.958 bits (1125), Expect = 6.715e-145 Identity = 205/385 (53.25%), Postives = 272/385 (70.65%), Query Frame = 2
Query: 539 KNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
K P+ A+K + N+L+ +E EI Y E++F+G AKK V +DDE SY+ V HDHIAYR+EV++++GKGSFGQV K DHK N VALK+IRN+KRF QA E++ILE L+++D +NHN+VH+ + F FRNH+C+TFELL INLYEL+K N F GF+L +VR+F SIL CL +L+ K+IHCDLKPENI+L Q+G+ +KVIDFGSSCYEHQ++YTYIQSRFYR+PEVILG PYNM IDMWS GCI+AEL+TG PLFPGE+E +QLACI+E+LG+PP + + R ++F +S+G P+ N + RG R P + ++++ D SF+ FL+RCL W P RMTP +ALK W+
Sbjct: 148 KVPLTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNIN---------------NNRGGKRYP--DSKDLTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWI 515
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 293.893 bits (751), Expect = 1.466e-89 Identity = 152/356 (42.70%), Postives = 214/356 (60.11%), Query Frame = 2
Query: 686 NCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKM--IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGP---------------PGNKSIVSLLKNCSDH-SFVSFLKRCLQWLPQDRMTPREALKQEWLRR 1699
N GYDD+ + Y+ + R+E+ ++GKGSFGQVVKAYDH+ VA+K+I+N+K F QA E+R+LE + + D + IVH+ F FRNH+C+ FELL+ NLY+L++ F+G SL L RK A + L L ++ IHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG+PY++ IDMWS GCIL E+ TG PLF G +E DQ++ I+E+LGIPP ++E + +A+ + E G L+ + R Y+GP PG + + +D+ F + R L++ P R++P AL+ + RR
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKY-----------FERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRR 433
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 294.278 bits (752), Expect = 4.371e-89 Identity = 152/356 (42.70%), Postives = 214/356 (60.11%), Query Frame = 2
Query: 686 NCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKM--IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGP---------------PGNKSIVSLLKNCSDH-SFVSFLKRCLQWLPQDRMTPREALKQEWLRR 1699
N GYDD+ + Y+ + R+E+ ++GKGSFGQVVKAYDH+ VA+K+I+N+K F QA E+R+LE + + D + IVH+ F FRNH+C+ FELL+ NLY+L++ F+G SL L RK A + L L ++ IHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG+PY++ IDMWS GCIL E+ TG PLF G +E DQ++ I+E+LGIPP ++E + +A+ + E G L+ + R Y+GP PG + + +D+ F + R L++ P R++P AL+ + RR
Sbjct: 149 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKY-----------FERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRR 493
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q92630|DYRK2_HUMAN (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3) HSP 1 Score: 615.15 bits (1585), Expect = 0.000e+0 Identity = 293/469 (62.47%), Postives = 352/469 (75.05%), Query Frame = 2
Query: 317 YRESDNKNVFLDT-----SQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ ++ NK L T + + G PVV L DS +Q +S SM G + P+ E AMK YM KLT+FEHHEIFSYPEIYF+G NAKKR G+ GG +N GYDD+Q SYV V HDH+AYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD + N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L++ SKRAK F++S+GYPRYC + +DG ++L G RS+RGK RGPP ++ + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 94 FEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQL---------DSIHRRQGSSTSLKSMEG-------------MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP 540
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5U4C9|DYRK2_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Mus musculus OX=10090 GN=Dyrk2 PE=2 SV=1) HSP 1 Score: 614.379 bits (1583), Expect = 0.000e+0 Identity = 285/434 (65.67%), Postives = 343/434 (79.03%), Query Frame = 2
Query: 449 QSRGSSTISMTA--SFTKDSLTNVSRRAGS------------YEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
Q G +T+ T + L ++ RR GS + +P+ E AMK YM KLT+FEHHEIFSYPEIYF+G NAKKR G+ GG +N GYDD+Q SYV V HDH+AYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD + N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRS IKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L++ SKRAK F++S+GYPRYC + +DG ++L G RS+RGK RGPP ++ + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 105 QPNGLTTVGKTGLPGVPERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP 538
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5ZIU3|DYRK2_CHICK (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Gallus gallus OX=9031 GN=DYRK2 PE=2 SV=1) HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0 Identity = 279/395 (70.63%), Postives = 331/395 (83.80%), Query Frame = 2
Query: 524 AGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
G + + + E AMK YM KLT+FEH+EIF Y EIYF+G NAKKR GV+GG +NCGYDD+Q SY+ V HDHIAYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD +N N++H+LE+FTFR+H+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILG+ Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P L+++SKRAK F++S+GYPRYC I +DG IIL G RS+RGK RGPP ++ + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 71 TGKVKASVMTPEQAMKQYMQKLTTFEHNEIFGYTEIYFLGPNAKKRQGVIGGPNNCGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKMHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNNMNVIHMLENFTFRSHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSPKLLDSSKRAKNFVSSKGYPRYCTITTLSDGSIILNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAIRMTPSQALRHPWLRRRLP 465
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q922Y0|DYRK3_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Mus musculus OX=10090 GN=Dyrk3 PE=1 SV=1) HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0 Identity = 276/445 (62.02%), Postives = 335/445 (75.28%), Query Frame = 2
Query: 413 RTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNH-SQDNCPSTAV 1744
R N + S + S SS S S S + + + P+ E A+K Y + LT++E EI SYPEIYFVG NAKKR GV+GG +N GYDD +Y++V DH+AYR+EV+KI+GKGSFGQV + YDHK YVALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNHVCM FELL+I+LYELIKKNKFQGFS+QLVRKFA SIL LD LH+NK+IHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILG Y+ ID+WSFGCILAEL TG PLFPGEDE DQLAC+IELLG+PP+ L+E SKRAK FINS+G PRYC++ TDG ++L G RS+RGK RGPPG+K + LK C D+ F+ FLKRCLQW P R+TP +AL+ W+ + P + D P V
Sbjct: 95 RRSNTLQSDGISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTMDKVPGKRV 539
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q4V8A3|DYRK3_RAT (Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Rattus norvegicus OX=10116 GN=Dyrk3 PE=2 SV=1) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 275/434 (63.36%), Postives = 332/434 (76.50%), Query Frame = 2
Query: 413 RTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKN--PINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
R + + S + S SS S S DSL V S P+ E A+K Y + LT++E EI SYPEIYFVG NAKKR GV+GG +N GYDD +Y++V DH+AYR+EV+KI+GKGSFGQV + YDHK YVALKM+RNEKRF RQAAEEIRILE+LKKQD + + N++H+LESFTFRNHVCM FELL+I+LYELIKKNKFQGFS+QLVRKFA SIL LD LH+NK+IHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILG Y+ ID+WSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP+ L+E SKRAK FINS+G PRYC++ TDG ++L G RS+RGK RGPPG+K + LK C D+ F+ FLKRCLQW P R+TP +AL+ W+ + P
Sbjct: 95 RRTSTLQSDGVSNSEKSSPASQGKS--SDSLGTVKCSLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVTTQTDGRVVLLGGRSRRGKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSAP 526
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A1I8JL07 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 644.04 bits (1660), Expect = 0.000e+0 Identity = 281/387 (72.61%), Postives = 331/387 (85.53%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ ETAMKLYM KL++FEHHEIFS+P++YFVGQNA KR GV+GG +N GYDDEQ SY + HDHI+YR+EV+KI+GKGSFGQV+K +DHK N VALKM+RNEKRFTRQA+EEIRILE L +QD ++HN+VHILE FTFRNHVC+TFELL++NLYELIKKNKFQGFSLQLVRKFAHSIL CLD+LHRNK+IHCDLKPENILLK QGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILG Y M IDMWS GCILAEL+TG P+FPGEDE DQLAC +E+LG PP L+E SKR ++F +SRG+PRYC++E D DG LKG RS+RGK+RGPPG+K++ + L+ C D F+ FL RCL W P +RMTP EAL+ +WL+R+ P
Sbjct: 1237 MTPETAMKLYMQKLSTFEHHEIFSFPQVYFVGQNANKRQGVVGGPNNSGYDDEQGSYQHTAHDHISYRYEVLKIIGKGSFGQVLKCHDHKTNSQVALKMVRNEKRFTRQASEEIRILEQLLRQDRDNSHNVVHILEHFTFRNHVCITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDMLHRNKIIHCDLKPENILLKCQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELYTGVPIFPGEDEGDQLACAMEVLGAPPTRLLEASKRTRVFFSSRGHPRYCSVETDADGATQLKGGRSRRGKFRGPPGSKTLSTALRGCEDRHFLDFLTRCLHWAPDERMTPHEALRHDWLKRRLP 1623
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A183ARR5 (Protein kinase domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS9651 PE=4 SV=1) HSP 1 Score: 629.017 bits (1621), Expect = 0.000e+0 Identity = 292/431 (67.75%), Postives = 346/431 (80.28%), Query Frame = 2
Query: 464 STISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFIN-SRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRR---KPPNHSQDNCPSTAV 1744
ST + + + S+ N+ GS N + E AMKLY++KLT +EHHEIF YP+IYFVG NAKKR GV+G +N GYDD+Q SY+ HDH+AYR+EV+KILGKGSFGQVVKAYDHK YVALKM+RNEKRFT QAAEEIRILE LK+QD + N+VH+LE FTFRNHVCMTFELL++NLYELIK++KFQGF LQLVRKFAHSIL+CLD+LHRNK+IHCDLKPENILLKQQGRSGIKVIDFGSSCYE QRIYTYIQSRFYRAPEVILG Y ID+WSFGCILAEL TG PLFPGEDE DQLACIIELLG+PP+ L+E +R K F + + GYPRYC + D DG ++L+ ++SKRGK RG PG++S+V+ L C D +F+ FL+RCLQWLP++RMTPREA + EWLRR KPP +T+V
Sbjct: 168 STTTHCPTSSSVSVPNLLPNGGS--GNGLTPEMAMKLYVHKLTPYEHHEIFGYPQIYFVGHNAKKRSGVLGAPNNGGYDDDQGSYLNTAHDHVAYRYEVLKILGKGSFGQVVKAYDHKTGTYVALKMVRNEKRFTHQAAEEIRILEQLKQQDKDNTRNVVHMLEHFTFRNHVCMTFELLSMNLYELIKRSKFQGFPLQLVRKFAHSILVCLDMLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYESQRIYTYIQSRFYRAPEVILGFKYGSAIDIWSFGCILAELLTGAPLFPGEDEGDQLACIIELLGMPPQKLLEQCRRVKHFFSTTHGYPRYC-MATDADGRVVLRPSKSKRGKLRGTPGSRSLVTALNGCEDAAFLDFLRRCLQWLPEERMTPREAFRHEWLRRRLPKPPATGNTTSSATSV 595
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A3Q1JSB3 (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 OS=Anabas testudineus OX=64144 PE=4 SV=1) HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0 Identity = 307/514 (59.73%), Postives = 376/514 (73.15%), Query Frame = 2
Query: 317 YRESDNKNVFLDTSQI--------INPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIGVHENFLMNNACLVP 1834
Y E+ NK L TSQ PG P+ + A S+P + R S S ++ +K + NP+++E MK +M+K++SFEHHE+FS+PEIYFVG NAKKR GVMGG +N GYDD+Q SY++V HDHIAYR+EV+K++GKGSFGQVVKA+DHK +VALKM+RNEKRF RQAAEEIRILE+L+KQD S+ N++H++E+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLDLLHR ++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILGS Y M IDMWS GCILAEL TG PL PGEDEADQLACIIELLG+P + L+E SKRAK F++S+GYPRYC + D +L G RS+RGK RGPPG+K + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P P T G ++T++ R +E+ + + + L P
Sbjct: 73 YEENTNKRPVL-TSQPNGLAPLNSSRPGLPLPDRQSSA---------SEPAQHCRQGSATSNKSTDSKPKV------------NPMSAEQVMKQFMSKMSSFEHHEVFSFPEIYFVGPNAKKRSGVMGGANNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKLQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSSMNVIHMMENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDLLHRTRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLEGSKRAKNFVSSKGYPRYCTVTTLPDSSTVLNGGRSRRGKVRGPPGSKDWSAALKGCDDPLFLDFLKQCLEWDPALRMTPSQALRHPWLRRRLPK------PPT---GTTTGEKTSSSKRGTANESAISSISKLAP 555
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: I3KNL6 (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 OS=Oreochromis niloticus OX=8128 GN=dyrk2 PE=4 SV=1) HSP 1 Score: 626.706 bits (1615), Expect = 0.000e+0 Identity = 300/468 (64.10%), Postives = 359/468 (76.71%), Query Frame = 2
Query: 317 YRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRR---KPPN 1711
Y E+ NK L TSQ N P+ + + + S+P R SS S ++ K + NP+ E AMK +M+K++SFEHHE+FSYPE+YFVGQNAKKR GV+GG +N GYDD+Q SY++V HDHIAYR+EV+K++GKGSFGQVVKA+DHK +VALKM+RNEKRF RQAAEEIRILE+LKKQD S+ N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILGS Y M IDMWS GCILAEL TG PL PGEDEADQLACIIELLG+P + L++ SKRAK F++S+GYPRYC + DG +L RS+RGK RGPPG+K + LK C D F+ FLK+CL+W P R+TP AL+ WLRR KPP+
Sbjct: 73 YEENTNKRPVL-TSQP-NGLAPISSSRPGLPLPDRQTSASEPAHHHRQSSAASNKSTDNKPKV------------NPMTPEQAMKQFMSKISSFEHHEVFSYPEVYFVGQNAKKRQGVIGGANNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLDGSKRAKNFVSSKGYPRYCTVTTLPDGTTVLNSGRSRRGKMRGPPGSKDWSTALKGCDDAHFIDFLKQCLEWDPALRITPNHALRHPWLRRRLPKPPS 526
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A267DM35 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033881g1 PE=4 SV=1) HSP 1 Score: 626.706 bits (1615), Expect = 0.000e+0 Identity = 281/389 (72.24%), Postives = 332/389 (85.35%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+ + ETAMKLYM KL++FEHHEIFS+P++YFVGQNA KR GV+GG +N GYDDEQ SY + HDHI+YR+EV+KI+GKGSFGQV+K +DHK N VALKM+RNEKRFTRQA+EEIRILE L +QD ++HN+VHILE FTFRNHVC+TFELL++NLYELIKKNKFQGFSLQLVRKFAHSIL CLD+LHRNK+IHCDLKPENILLK QGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILG Y M IDMWS GCILAEL+TG P+FPGEDE DQLAC +E+LG PP L+E SKR ++F +SRG+PRYC++E D DG LKG RS+RGK+RGPPG+K++ + L+ C D F+ FL RCL W P +RMTP EAL+ +WL+R+ P
Sbjct: 142 HAMTPETAMKLYMQKLSTFEHHEIFSFPQVYFVGQNANKRQGVVGGPNNSGYDDEQGSYQHTAHDHISYRYEVLKIIGKGSFGQVLKCHDHKTNSQVALKMVRNEKRFTRQASEEIRILEQLLRQDRDNSHNVVHILEHFTFRNHVCITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDMLHRNKIIHCDLKPENILLKCQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELYTGVPIFPGEDEGDQLACAMEVLGAPPTRLLEASKRTRVFFSSRGHPRYCSVETDADGATQLKGGRSRRGKFRGPPGSKTLSTALRGCEDRHFLDFLTRCLHWAPDERMTPHEALRHDWLKRRLP 530
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:103042530]) HSP 1 Score: 600.127 bits (1546), Expect = 0.000e+0 Identity = 283/410 (69.02%), Postives = 339/410 (82.68%), Query Frame = 2
Query: 479 TASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
T + S T++ + P+ E AMK Y++KL++FEH EIF+YPEI+FVG NAKKR GV+GG++N GYDD+Q SY++V HDHIAYR+EV+K++GKGSFGQVVKAYDHK + +VALKM+RNEKRF RQAAEEIRILE+L+KQD S N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR+YTYIQSRFYRAPEVILGS Y M IDMWS GCILAEL TG PL PGEDE DQLAC+IELLG+P + L+++SKRAK FI+S+GYPRYC + DG + L G RS+RGK RGPPG+K V+ LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P
Sbjct: 116 TTQCRQGSSTSIKSTDSKPKPAPLTPEQAMKQYLSKLSTFEHQEIFNYPEIFFVGPNAKKRPGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKTHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIELLGMPSQKLLDSSKRAKNFISSKGYPRYCTVTSLPDGTVALNGGRSRRGKLRGPPGSKDWVTALKGCDDPLFLDFLKQCLEWDPTLRMTPSQALRHPWLRRRLP 525
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 264/389 (67.87%), Postives = 325/389 (83.55%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
P+ +E A+K Y +LT+ E E+ +Y EI+FVG NAKKR V GG++NCGYDD+Q Y++V HDHIAYR+E +K++GKGSFGQV K YDHK + ++ALKM+RNEKRF RQAAEEIRILE+LKKQD + + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ L R+K+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP+ L+E +KRAK FINS+G+PRYC + ++G ++L G+RS+RGK RGPPG+K V+ LK C D +F+ FL++CL W P RMTP AL+ WL ++ P
Sbjct: 134 GPLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTTLSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKRLP 522
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0 Identity = 264/389 (67.87%), Postives = 325/389 (83.55%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
P+ +E A+K Y +LT+ E E+ +Y EI+FVG NAKKR V GG++NCGYDD+Q Y++V HDHIAYR+E +K++GKGSFGQV K YDHK + ++ALKM+RNEKRF RQAAEEIRILE+LKKQD + + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ L R+K+IHCDLKPENILLKQQGRSGIKVIDFGSSC++HQR+YTYIQSRFYRAPEVILGS Y M IDMWSFGCILAEL TG PLFPGEDE DQLAC++ELLG+PP+ L+E +KRAK FINS+G+PRYC + ++G ++L G+RS+RGK RGPPG+K V+ LK C D +F+ FL++CL W P RMTP AL+ WL ++ P
Sbjct: 126 GPLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTTLSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKRLP 514
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 465.307 bits (1196), Expect = 9.669e-156 Identity = 218/414 (52.66%), Postives = 298/414 (71.98%), Query Frame = 2
Query: 458 GSSTISMTASFTKDSLTNVSRRAGSYE--KNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
GSS +++ S T+ S+ N + +YE + P++ A+K + ++LT +E EI Y EI+++G + KK G G N GYDDE SY+ V HDHIAYR+EV++++GKGSFGQV+K DHK N VA+K+IRN+KRF +QA E++IL+ ++++D S HN++H+ E F FRNH+C++FELL NLYELIKKN FQGFSL L+R+FAHS+L CL +LHR K+IHCDLKPENILL Q+G+ IKV+DFGSSCYE QR+YTYIQSRFYR+PEVILG PY+M IDMWS GCILAEL+TG PLFPGE E +Q+ACI+E++G+PP ++ + R ++F +S+G PR + +GK R P +K + S+LK +D F+ F++RCL W P RMTP E ++ EW+
Sbjct: 100 GSSVDNISESLTR-SIINKFEKIRTYEGQRLPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVT---------------NSKGKKRR-PNSKELASVLKT-NDPLFLDFIRRCLVWDPTKRMTPDEGMQHEWI 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 466.463 bits (1199), Expect = 9.999e-156 Identity = 243/527 (46.11%), Postives = 334/527 (63.38%), Query Frame = 2
Query: 128 GNNNLTNAKSDPQLAAKRNFGNIQNFQYNNINDEMSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQ--SR-GSSTISMTASFTKDSLTNVSRRAGSYE--KNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
G+ N N + P+ A F + Q Q E + N N S K G GT + L S I P + L+ V+ +P Q +R GSS +++ S T+ S+ N + +YE + P++ A+K + ++LT +E EI Y EI+++G + KK G G N GYDDE SY+ V HDHIAYR+EV++++GKGSFGQV+K DHK N VA+K+IRN+KRF +QA E++IL+ ++++D S HN++H+ E F FRNH+C++FELL NLYELIKKN FQGFSL L+R+FAHS+L CL +LHR K+IHCDLKPENILL Q+G+ IKV+DFGSSCYE QR+YTYIQSRFYR+PEVILG PY+M IDMWS GCILAEL+TG PLFPGE E +Q+ACI+E++G+PP ++ + R ++F +S+G PR + +GK R P +K + S+LK +D F+ F++RCL W P RMTP E ++ EW+
Sbjct: 21 GSQNRRNRRVQPEAARPEAFPHPQRLQA-----ESTRLGTNRNYSQKC-GTETGTLPQLDPPVKPVVVPNGKLLHQSDGI---LPNIVKQLVQNVQQSQEERERPRPQFPARFGSSVDNISESLTR-SIINKFEKIRTYEGQRLPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVT---------------NSKGKKRR-PNSKELASVLKT-NDPLFLDFIRRCLVWDPTKRMTPDEGMQHEWI 520
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 588.571 bits (1516), Expect = 0.000e+0 Identity = 259/380 (68.16%), Postives = 317/380 (83.42%), Query Frame = 2
Query: 551 NSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEW 1690
+ + A++LY KLT++EH EI++Y EIYFVG NAKKR GV+GG NCGYDDEQ SYV+V HDH+AYR+EV+K++GKGSFGQVVKA+DHK +VALKM+RNEKRF RQAAEEIRILE+L+KQD ++ NI+H+LESFTFR HVCMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LHRN++IHCDLKPENILLKQ GRSGIKVIDFGSSC+EHQR+YTYIQSRFYRAPEV+LG+ Y IDMWS GCILAEL TG+PL PGEDE DQLAC +ELLG+PP+ L+ KR++ F++SRG+PRYC + DG ++L RS+RGK RGPPG++ + + L+ C D + FL+ CL+W P +R+TP +AL+ W
Sbjct: 95 SPDQAVRLYGQKLTAYEHQEIYNYAEIYFVGHNAKKRPGVVGGASNCGYDDEQGSYVHVAHDHVAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRENSMNIIHLLESFTFRGHVCMTFELLSMNLYELIKKNKFQGFSLALVRKFAHSILQCLDTLHRNRIIHCDLKPENILLKQPGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVVLGARYGPPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELLGMPPQRLLAQGKRSRNFVSSRGHPRYCGVTEAPDGAVVLNAGRSRRGKPRGPPGSRELPAALRGCDDPLLLDFLRGCLEWEPSERLTPAQALRHPW 474
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 571.622 bits (1472), Expect = 0.000e+0 Identity = 258/389 (66.32%), Postives = 317/389 (81.49%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIK-VIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPN 1711
++ E AM+ YM++L+ FEHHEIF+Y E+YFVG +AKKR + G +N G+DDEQ SY++V HDH+AYR+EV++++GKGSFGQVVKAYDH+ + YVALKM+RNEKRF RQAAEEIRILE+LKKQD + N++H+LESF FRNH+CMTFELL++NLYELIKKNKFQGFSLQ+VRKFAHSILLCL+ LH+N++IHCDLKPENILL+QQGRSGIK +IDFGSSCYEHQR+YTYIQSRFYRAP G Y + IDMWS GCILAEL TG+PL PGEDE DQLAC +EL G PP L+E SKRA+ F +S G+PRYC + G ++L G R++RGK RGPP ++ + LK C DH F+ FLK+CL W P R+TP +ALK WLRR+P N
Sbjct: 104 MSPEQAMRKYMHRLSMFEHHEIFNYHEVYFVGPSAKKRQATLSGVNNNGFDDEQGSYIHVPHDHVAYRYEVLRVIGKGSFGQVVKAYDHRTHQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKENTMNVIHMLESFNFRNHICMTFELLSMNLYELIKKNKFQGFSLQVVRKFAHSILLCLNALHKNRIIHCDLKPENILLRQQGRSGIKIIIDFGSSCYEHQRVYTYIQSRFYRAP----GGRYGLPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELTGSPPARLLEQSKRARQFFSSLGHPRYCTVTTLPGGPVVLNGGRTRRGKLRGPPSSRDWTTALKGCDDHLFIDFLKKCLDWDPATRLTPSQALKHPWLRRRPLN 488
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk1aa (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Source:ZFIN;Acc:ZDB-GENE-050302-29]) HSP 1 Score: 287.73 bits (735), Expect = 1.275e-86 Identity = 145/335 (43.28%), Postives = 206/335 (61.49%), Query Frame = 2
Query: 749 RFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKM--IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYR---------------GPPGNKSIVSLLKNCSDH-SFVSFLKRCLQWLPQDRMTPREALKQEWLRR 1699
R+E+ ++GKGSFGQVVKAYDH+ +VA+K+I+N+K F QA E+R+LE + K D + IVH+ F FRNH+C+ FELL+ NLY+L++ F+G SL L RKFA + L L ++ IHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG PY++ IDMWS GCIL E+ TG PLF G +E DQ+ I+E+LG+PP ++E + +A+ + E +DG +K + + +Y+ G PG + + +D+ F + R L + P+ R+TP AL+ + ++
Sbjct: 161 RYEIDSLIGKGSFGQVVKAYDHQEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTDMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGLPPTHMLEQAPKARKY-----------FERLSDGSWTVKKTKDSKREYKTAGSRKLHDIIGVESGGPGGRRMGEAGHTVADYLKFKDLILRMLDYDPKTRITPFYALQHNFFKK 484
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007952.1 (pep scaffold:Pmarinus_7.0:GL476685:157428:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007952.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 246.514 bits (628), Expect = 3.229e-76 Identity = 138/331 (41.69%), Postives = 195/331 (58.91%), Query Frame = 2
Query: 725 VGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQA-AEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLR--RKPP 1708
V H+H+ YR+EV+++LG+GSFG+V+K DHK +VA+K++ N RF EI IL+ L+ SS I+ ++E F+FR C+ FELLN NL +K QGF L++VR FA S+L L+ L +IH DLKP NI + +K+ DFG SC++H+ +T IQ+R YRAPEVIL Y+ DMWS GC LAEL +G LFPG DQL I+E+ G+PP+ +IE S+ F + + N+ R RG R PG++++ L+ +H F F++ CLQW P+ R+TP A+ EW+R R PP
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHRREIEILKRLQTARESSK--IIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFACKDFS--SNV-------------RLNRGLVR-VPGSRALPLALRTTDEH-FTDFIRSCLQWDPEWRLTPHGAMDHEWVRAPRMPP 312
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007958.1 (pep scaffold:Pmarinus_7.0:GL476685:157443:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007958.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 243.817 bits (621), Expect = 3.068e-75 Identity = 135/325 (41.54%), Postives = 194/325 (59.69%), Query Frame = 2
Query: 725 VGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQA-AEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLR 1696
V H+H+ YR+EV+++LG+GSFG+V+K DHK +VA+K++ N RF EI IL+ L+ SS I+ ++E F+FR C+ FELLN NL +K QGF L++VR FA S+L L+ L +IH DLKP NI + +K+ DFG SC++H+ +T IQ+R YRAPEVIL Y+ DMWS GC LAEL +G LFPG DQL I+E+ G+PP+ +IE S R ++ + P + +I + RG R PG++++ L+ +H F F++ CLQW P+ R+TP A+ EW+R
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHRREIEILKRLQTARESSK--IIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEES-RVQLGFFAITKPTHWDIN-------------NHRGLVR-VPGSRALPLALRTTDEH-FTDFIRSCLQWDPEWRLTPHGAMDHEWVR 307
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: YAK1 (Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]) HSP 1 Score: 259.225 bits (661), Expect = 4.671e-76 Identity = 141/347 (40.63%), Postives = 207/347 (59.65%), Query Frame = 2
Query: 449 QSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSY----PEIYFVGQNAKKRYGVMGGTHNC--GYDDEQNSYVYVGHDHIAY----RFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENL-KKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFI 1456
Q + S M +K+ L V + + +NS+T ++ L S I +Y PE + KR C G+D+ + Y+ +D + ++ V+ ILG+G+FGQVVK + +A+K++++ + Q+ E +ILE L +K DP++ H+ + + +SF +NH+C+ FELL+ NLYEL+K+NKF G S+QL+R F IL L +L +K+IHCDLKPENILL + +K+IDFGSSC E + +YTYIQSRFYRAPE+ILG PY+ IDMWS GCI+AEL+ G P+FPG E +QL II+ LG PP +I+ K + F+
Sbjct: 263 QGQKLSIPQMQLCNSKNDLQPVLNATPKFRRASLNSKT-----ISPLVSVTKSLITTYSLCSPEFTYQTSKNPKRVLTKPSEGKCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFM 604
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: KNS1 (Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation [Source:SGD;Acc:S000003942]) HSP 1 Score: 150.599 bits (379), Expect = 1.747e-38 Identity = 90/289 (31.14%), Postives = 146/289 (50.52%), Query Frame = 2
Query: 701 DEQNSYVYVGHDHIAY--RFEVVKILGKGSFGQVVKAYDHKYNI-YVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILL---------------------KQQGRSG---------IKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIP-PKSLIENSKRAKMFINSR 1465
D+ YVY +D RF V +LG+G+FG+V+K D+KY YVA+K+IR R+ A E+RIL+ + DP + + E F ++NH+C+ +L ++Y+ + N F ++ A ++ + LH +IH DLKPENIL+ +++ G IK+IDFGS+ + ++ I +R YRAPE++LG ++ D+WS C+L EL G L+P + + +A + + G P P +I+ KMF S+
Sbjct: 294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIID-----KMFYKSK 577
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 135.576 bits (340), Expect = 7.034e-36 Identity = 97/328 (29.57%), Postives = 168/328 (51.22%), Query Frame = 2
Query: 749 RFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIR--NEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKK----NKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTY---IQSRFYRAPEVILGS-PYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRY-CNIEVDTDGHIILKGNRSKRGKYRGPPGN--KSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
+F+ ++ LG G++ V K + +YVALK ++ +E+ A EI +++ LK + NIV + + N + + FE ++ +L + + N +G L LV+ F +L L H NK++H DLKP+N+L+ ++G+ +K+ DFG + + T+ + + +YRAP+V++GS Y+ ID+WS GCILAE+ TG PLFPG ++ +QL I +++G P +SL + + P+Y NI+ + PP + + + K D + + FL LQ P R++ ++AL W
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE------NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK---------LPKYNPNIQ-------------------QRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 124.02 bits (310), Expect = 2.870e-31 Identity = 102/340 (30.00%), Postives = 164/340 (48.24%), Query Frame = 2
Query: 740 IAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIR--NEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILE-----SFTFRNHVCMTFELLNINLYELI--KKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFG-SSCYEHQR---------IYTYIQSRFYRAPEVILG-SPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIEN--SKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
I ++++V ++G+G++G V A I VA+K I+ ++K F + EI++L + + NI+ IL+ S N V + EL+ +L ++I + + F S V+ F + IL L +H ++IH D+KP N+LL +KV DFG + C + Y+ +R+YRAPE++L Y +D+WS GCILAE+ +G PLFPG D QL I+E+LG P SKRAK +I N+ + R P +++ S K + + L + LQ+ P R++ EAL+ +L
Sbjct: 9 IPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLL--NSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYI--------ANLPM------------------RPPLPWETVWS--KTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYL 313
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 124.02 bits (310), Expect = 9.265e-31 Identity = 77/234 (32.91%), Postives = 127/234 (54.27%), Query Frame = 2
Query: 740 IAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIR---NEKRFTRQAAEEIRILENLKKQDPSSNHNI-VHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILG-SPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLI 1426
I R+ + +G G+FG V A D + VA+K I + ++ E+++L++L+ ++ +I + LE F EL +L+ L++ + Q V+ F + IL L +H +IH DLKP NIL+ + +K+ DFG + + ++ Y+ +R+YRAPE++L Y++ +D+WS GCI AE+ G PLFPG+D Q + I +LLG PPK +I
Sbjct: 19 ITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVT------ELQGTDLHRLLQTRPLEK---QFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINEN--CDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVI 241
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO46144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQP1]) HSP 1 Score: 613.994 bits (1582), Expect = 0.000e+0 Identity = 292/428 (68.22%), Postives = 337/428 (78.74%), Query Frame = 2
Query: 434 SKPLKQSRGSSTISMTASFTKDSLTNVSRR-----AGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRK 1702
S P+ G ++S T S + + RR GS + +E AMK YM+KL+ +E HEIF+Y +IYFVG+ AKKR GV+GG +NCGYDDEQ SY++V DHIAYR+EV+KI+GKGSFGQVVKA DHK N +VALKM+RNEKRF RQA EEIRILE+LKKQD + HNI+H+LE FTFRNHVCMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILG+ Y M IDMWSFGCILAEL TG PLFPGEDE DQLAC +ELLG P+ L E SKRAK FINS+GYPRYC I DG + + G RS+RGK RG P +K+ V LK C D F+ FLKRCL+W P RMTP +AL+ WLRR+
Sbjct: 60 SMPVVHDHGLPSVSRTGR----SPSVIERRQSSNSTGSQKSRSFTAEVAMKQYMHKLSGYETHEIFNYSQIYFVGEAAKKRQGVVGGANNCGYDDEQGSYIHVPKDHIAYRYEVLKIIGKGSFGQVVKALDHKTNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHMLEHFTFRNHVCMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACNMELLGYIPEKLRETSKRAKNFINSKGYPRYCTITTLPDGSVAVSGGRSRRGKTRGAPNSKTFVQALKGCDDAMFIDFLKRCLEWDPSARMTPSQALRHPWLRRR 483
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO36294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ45]) HSP 1 Score: 434.876 bits (1117), Expect = 2.026e-148 Identity = 203/353 (57.51%), Postives = 273/353 (77.34%), Query Frame = 2
Query: 581 NKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQ 1639
+++T+FE EI YPE++F+G +AKK GV G N YDD+ SY+ HDH+AYR+EV+++LGKGSFGQVVKA DHK +VA+K+IRN+KRF +QA E++IL+NL+K+D + HN++H++E F FRNH+C+TFEL+ +NLYELIKKN FQGFSL L+R+FA ++L CL ++H+ K+IHCDLKPENILL+Q+G++ IKVIDFGSSCYEHQR+YTYIQSRFYR+PEVILG PY+M IDMWSFGCILAEL+TG PLFPGE+E +QLACI+E+LG+P LIE++ R ++F +S+G PR + +GK R P ++ I + LK +D F+ FLK+CL+
Sbjct: 3 DRITTFEQSEILDYPEVWFLGLDAKKIDGVPGAPQNNNYDDDNGSYLKALHDHLAYRYEVLEVLGKGSFGQVVKALDHKTGQHVAVKIIRNKKRFHQQALVEVKILDNLRKKDKDNTHNLIHMIEHFYFRNHLCITFELMGMNLYELIKKNNFQGFSLALIRRFAFALLHCLKVIHKEKIIHCDLKPENILLRQRGQTSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPSPKLIESASRRRLFFDSKGIPRCIT---------------NSKGKKR-RPSSRDISAALKT-NDALFLDFLKQCLE 338
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO45187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTC8]) HSP 1 Score: 285.804 bits (730), Expect = 2.677e-89 Identity = 154/365 (42.19%), Postives = 218/365 (59.73%), Query Frame = 2
Query: 683 HNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKM--IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEV-DTDGHIILKGNRSKR---GKYRGPPGNKSIVSLLKNCSDH-SFVSFLKRCLQWLPQDRMTPREALKQEWLRRKP-----PNHSQDNCPSTA 1741
+N GYDDE Y+ + R+E+ ++GKGSFGQV KAYDH+ ++A+K+I+N+K F QA E+++LE + K DP + IV + F +RNH+C+ FELL+ NLY+L++ F+G SL L RKFA + L L ++ IHCDLKPENILL RS IK++DFGSSC QRIY YIQSRFYR+PEV+LG PYN+ IDMWS GCIL E+ TG PLF G +E DQ+ I+E+LG+PPK +++N+ +A+ F + Y ++V D + G+R G G PG + + D+ F + R L + + R+ P AL + ++ HS N P+
Sbjct: 56 YNDGYDDENYDYIVKAGEKWFDRYEIESLIGKGSFGQVCKAYDHQEKEHIAVKIIKNKKPFLNQAQIEVKLLELMNKNDPDGKYYIVRLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLCSPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQIGQRIYQYIQSRFYRSPEVLLGIPYNLAIDMWSLGCILVEMHTGEPLFSGANEFDQMMKIVEVLGMPPKDILDNAPKARKFFDRLPDGSYQCLKVKDGVKEYLSPGSRKLHDILGCETGGPGGRRLGEAGHTLQDYLKFKDLILRMLDYDRKTRIVPYAALHHCFFKKTAEEGTNTTHSATNSPAMG 420
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO49238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGV4]) HSP 1 Score: 205.297 bits (521), Expect = 4.979e-60 Identity = 124/337 (36.80%), Postives = 183/337 (54.30%), Query Frame = 2
Query: 758 VVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILL----KQQGRSGIKVIDFGSSCYEHQRI-YTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKR-GKYRGPPGNKSIVSLLKNCSD-------------------HSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
V++ LG+G+FGQVVK + N VA+K++++ + RQ EI IL L ++ S +N V +E F +NH C+ FE+L NLY+ +K++KF L+ +R +L+ L L +IH DLKPENI+L KQ R +KVIDFGS+ + + + TY+QSR+YRAPEVILG P+ IDMWS GC++AEL+ G PL+PG E DQ+ II+ G+P L+ N+ + SR + + N + N +R K K I + L + + + FVS LKR L + R+TP EAL +++
Sbjct: 1 VLEFLGRGTFGQVVKCWKKGTNELVAIKILKDHPSYARQGQIEISILAKLSAEN-SEAYNFVRAIECFQHKNHTCLVFEMLQQNLYDYLKQSKFNPLPLKHIRPIVQQVLVALSKLRTLGLIHADLKPENIMLVDPDKQPFR--VKVIDFGSATHVSKVVCSTYLQSRYYRAPEVILGLPFCESIDMWSLGCVIAELFLGWPLYPGSSEFDQIRYIIQTQGLPYDHLLNNATK-----TSRFFKKAINTHTGVLEWKLKNANEHERETKIPSKEARKYIFNSLDDIAQVNLSSSLTGNERIAEKIDRYEFVSLLKRMLTIDQEKRITPEEALSHQFV 329
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO33758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR83]) HSP 1 Score: 183.726 bits (465), Expect = 5.221e-51 Identity = 105/350 (30.00%), Postives = 184/350 (52.57%), Query Frame = 2
Query: 698 DDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILL-------------KQQGR----SGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHS-FVSFLKRCLQWLPQDRMTPREALKQEWL 1693
DDE +Y D + R+EV +LG+G+FG+V++ YD K VA+K+I+N +++ A EI++LE + +++ + +L+ F H+C+ FE + +++++ +K N ++ + L VR ++ +++ + LH K+ H DLKPEN+L KQ R S +++IDFGS+ +EH+ T + +R YRAPEVIL ++ D+WS GCI+ EL+TG LF + + LA + ++G P + S++ K F + +E D +S GKY +L + H F + L L++ P+ R+T +EA++ +
Sbjct: 107 DDEDGHLIYHKGDQLHSRYEVHCLLGEGTFGKVLECYDKKTGDVVAVKVIKNIEKYREAAKLEIKVLEKINQKNRYGKSLCIKMLDWFNHHGHMCLVFEKMGLSVFDFMKDNNYEPYPLDQVRHISYQLIVAVKFLHEMKLTHTDLKPENMLFVNSDCDVFYNKDTKQDQRYVKSSHMRLIDFGSATFEHEHHSTTVSTRHYRAPEVILELGWSYPCDIWSIGCIMFELYTGFTLFQTHENREHLAMMERIIGPIPSDFAKKSRKTKYFYKGK-------LEWD---------EKSSSGKYVRENCKPLKKYMLSDSEGHQLFFNLLDYLLEYDPEKRITAKEAMQHPFF 440
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:101170635]) HSP 1 Score: 620.542 bits (1599), Expect = 0.000e+0 Identity = 283/421 (67.22%), Postives = 342/421 (81.24%), Query Frame = 2
Query: 473 SMTASFTKDSLTNVSRRAGSYEK-NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCP 1732
S A + S ++ A S K NP+ +E AMK +M+K++SFEHHE+FS+ E+YF+G +AKKR GV+GG +N GYDD+Q SY+ V HDHIAYR+EV+K++GKGSFGQVVKA+DHK +VALKM+RNEKRF RQAAEEIRILE+LKKQD S+ N++H+LE+FTFRNH+CMTFELL++NLYELIKKNKFQGFSL LVRKFAHSIL CLD LH+N++IHCDLKPENILLKQQGRSGIKVIDFGSSC+EHQR+YTYIQSRFYRAPEVILGS Y M IDMWS GCILAEL TG PL PGEDEADQLACIIELLG+P + +++ SKRAK F++S+GYPRYC + +DG +L G RS+RGK RGPPG+K + LK C D F+ FLK+CL+W P RMTP +AL+ WLRR+ P P
Sbjct: 99 SEAAQHGRQSSATSNKPADSKPKTNPLTAEQAMKQFMSKMSSFEHHEVFSFSEVYFIGPSAKKRSGVLGGPNNGGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKILDASKRAKNFVSSKGYPRYCTVTTLSDGTTVLNGGRSRRGKVRGPPGSKVWSTALKGCDDPLFLDFLKQCLEWDPAHRMTPSQALRHSWLRRRLPKPPTGTTP 519
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0 Identity = 261/395 (66.08%), Postives = 318/395 (80.51%), Query Frame = 2
Query: 524 AGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+GS P+ + A++LY ++L+ E EI SYP++YFVG NAKKR V GG++NCGYDDEQ Y++V HDH+AYR+E +KI+GKGSFGQV K YDHK ++ALKM+RNEKRF RQA EEIRILE+L KQD + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ L R+++IHCDLKPENILLKQQGRSGIKVIDFGSSC+EHQR+YTYIQSRFYRAPEVILGS Y + IDMWSFGCILAEL TG PLFPGEDE+DQLAC +ELLG+PP ++E +KRAK FINS+G+PRYC G +L G+RS+RGK RGPP +K LK C D +F+ F+K+CL W P R+TP +AL+ WL R+ P
Sbjct: 142 SGSKMCGPLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRLP 536
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0 Identity = 261/395 (66.08%), Postives = 318/395 (80.51%), Query Frame = 2
Query: 524 AGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPP 1708
+GS P+ + A++LY ++L+ E EI SYP++YFVG NAKKR V GG++NCGYDDEQ Y++V HDH+AYR+E +KI+GKGSFGQV K YDHK ++ALKM+RNEKRF RQA EEIRILE+L KQD + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ L R+++IHCDLKPENILLKQQGRSGIKVIDFGSSC+EHQR+YTYIQSRFYRAPEVILGS Y + IDMWSFGCILAEL TG PLFPGEDE+DQLAC +ELLG+PP ++E +KRAK FINS+G+PRYC G +L G+RS+RGK RGPP +K LK C D +F+ F+K+CL W P R+TP +AL+ WL R+ P
Sbjct: 142 SGSKMCGPLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRLP 536
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0 Identity = 271/456 (59.43%), Postives = 336/456 (73.68%), Query Frame = 2
Query: 524 AGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL-RRKP-----------------PNHSQDNCPSTAVDGDLIYKETATGDRIGVHENFLMNNACLVPV 1837
+GS P+ + A++LY ++L+ E EI SYP++YFVG NAKKR V GG++NCGYDDEQ Y++V HDH+AYR+E +KI+GKGSFGQV K YDHK ++ALKM+RNEKRF RQA EEIRILE+L KQD + N+VH+LE+FTFRNH+CMTFELL++NLYELIK+NKFQGFSL LVRKFAHSIL CL+ L R+++IHCDLKPENILLKQQGRSGIKVIDFGSSC+EHQR+YTYIQSRFYRAPEVILGS Y + IDMWSFGCILAEL TG PLFPGEDE+DQLAC +ELLG+PP ++E +KRAK FINS+G+PRYC G +L G+RS+RGK RGPP +K LK C D +F+ F+K+CL W P R+TP +AL+ WL RR P P+H + PS G T +++ N L ++ +P+
Sbjct: 84 SGSKMCGPLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRLPKPLAVTEKNQGAPVKRLPDHHSTSFPSILAKGGPALGSTPASNKL--RSNMLGDSGEAIPL 537
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk4 (dual specificity tyrosine-phosphorylation-regulated kinase 4 [Source:NCBI gene;Acc:101159741]) HSP 1 Score: 460.299 bits (1183), Expect = 6.993e-154 Identity = 215/391 (54.99%), Postives = 284/391 (72.63%), Query Frame = 2
Query: 521 RAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWL 1693
+A ++ P++ A+ + +LT FE EI +Y E++F+G ++K G G HN GYDDE SY+ V HDHIAYRFEV++++GKGSFGQV+K DHK N VA+KMIRN+KRF QA E++ILE +KK+D + HN++H+ E F FRNH+C++FELL +NLYELIKKN FQGFSL L+R+FAH++L CL +LH+ K+IHCDLKPENILL Q+G IKV+DFGSSCYE QR+YTYIQSRFYR+PEVILG PY+M IDMWS GCILAEL TG PLFPGE E +Q+ACI+E+LG+PP ++++ R K+F +S+G PR NI + +GK R P +K + + LK +D F+ F+K CL W P RMTP E L+ +W+
Sbjct: 123 KACEGQRLPMSPSEALNNFQERLTEFEQEEINAYAEVWFLGLGSQKIEGSQGAPHNSGYDDEHGSYIRVLHDHIAYRFEVLEVIGKGSFGQVLKCLDHKTNELVAIKMIRNKKRFHHQALVELKILEVIKKKDKDNLHNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSLALIRRFAHALLRCLQMLHKEKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELHTGYPLFPGESEVEQIACIMEVLGMPPNDFVQSASRRKLFFDSKGNPR--NI-------------TNSKGKKRR-PNSKELSAALKT-TDPLFLEFIKGCLTWDPTKRMTPDEGLQHQWI 496
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000042409.1 (SMESG000042409.1) HSP 1 Score: 1194.87 bits (3090), Expect = 0.000e+0 Identity = 568/571 (99.47%), Postives = 568/571 (99.47%), Query Frame = 2
Query: 92 MDKNIYLPWINSGNNNLTNAKSDPQLAAKRNFGNIQNFQYNNINDEMSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIGVHEN 1804
MDKNIYLPWINSGNNNLTNAKSDPQLAAKRNFGNIQNFQYNNINDEMSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNH QDNCPSTAVDGDLIYKETATGDRIG EN
Sbjct: 1 MDKNIYLPWINSGNNNLTNAKSDPQLAAKRNFGNIQNFQYNNINDEMSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHFQDNCPSTAVDGDLIYKETATGDRIGAREN 571
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000042409.1 (SMESG000042409.1) HSP 1 Score: 1100.5 bits (2845), Expect = 0.000e+0 Identity = 522/525 (99.43%), Postives = 522/525 (99.43%), Query Frame = 2
Query: 230 MSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDNCPSTAVDGDLIYKETATGDRIGVHEN 1804
MSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNH QDNCPSTAVDGDLIYKETATGDRIG EN
Sbjct: 1 MSGEIINNNLSCKLNGDINGTNHNTNVLKYRESDNKNVFLDTSQIINPGFPVVENNLLAKVRTKNMVDSKPLKQSRGSSTISMTASFTKDSLTNVSRRAGSYEKNPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHFQDNCPSTAVDGDLIYKETATGDRIGAREN 525
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0 Identity = 289/403 (71.71%), Postives = 338/403 (83.87%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRK--PPNHSQDNCPSTAVDG 1750
++ ++AM+ +M+KLT++EHHEIFSYP I+FVG NAKKR GV+GGT+NCGYDD+QNSY++V HDHIAYR+EV+K+LGKGSFGQVVKA DHK VA+KM+RNEKRFTRQAAEEIR+LE LKKQDP SN N++HI++ F FRNHVCMTFELL+INLYELIKKNKFQGFSLQLVRKFA+SILLCL+LL+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILG Y M IDMWSFGCILAEL+TG P+FPGEDE DQLACI+E+LG PP L + KR K+F S+ YPRYC D DG +ILKG RSKRG++RGPP +K++ + LKNC D F+ F RCL W+P+ RMTP+EALK WLRRK P N S +DG
Sbjct: 150 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 552
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0 Identity = 289/403 (71.71%), Postives = 338/403 (83.87%), Query Frame = 2
Query: 548 INSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTDGHIILKGNRSKRGKYRGPPGNKSIVSLLKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRK--PPNHSQDNCPSTAVDG 1750
++ ++AM+ +M+KLT++EHHEIFSYP I+FVG NAKKR GV+GGT+NCGYDD+QNSY++V HDHIAYR+EV+K+LGKGSFGQVVKA DHK VA+KM+RNEKRFTRQAAEEIR+LE LKKQDP SN N++HI++ F FRNHVCMTFELL+INLYELIKKNKFQGFSLQLVRKFA+SILLCL+LL+RNK+IHCDLKPENILLKQQGRSGIKVIDFGSSC EHQRIYTYIQSRFYRAPEVILG Y M IDMWSFGCILAEL+TG P+FPGEDE DQLACI+E+LG PP L + KR K+F S+ YPRYC D DG +ILKG RSKRG++RGPP +K++ + LKNC D F+ F RCL W+P+ RMTP+EALK WLRRK P N S +DG
Sbjct: 147 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDG 549
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000064198.1 (SMESG000064198.1) HSP 1 Score: 588.956 bits (1517), Expect = 0.000e+0 Identity = 279/424 (65.80%), Postives = 339/424 (79.95%), Query Frame = 2
Query: 542 NPINSETAMKLYMNKLTSFEHHEIFSYPEIYFVGQNAKKRYGVMGGTHNCGYDDEQNSYVYVGHDHIAYRFEVVKILGKGSFGQVVKAYDHKYNIYVALKMIRNEKRFTRQAAEEIRILENLKKQDPSSNHNIVHILESFTFRNHVCMTFELLNINLYELIKKNKFQGFSLQLVRKFAHSILLCLDLLHRNKMIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGSPYNMMIDMWSFGCILAELWTGTPLFPGEDEADQLACIIELLGIPPKSLIENSKRAKMFINSRGYPRYCNIEVDTD---GHII-------LKGNRSKRGKYRGPPGNKSIVSL-------------------LKNCSDHSFVSFLKRCLQWLPQDRMTPREALKQEWLRRKPPNHSQDN 1726
+P+ + AMKLYM++L++FEHHEIF+YP+IYFVG NAKK++G+ G +N GYDDE SY +V HDH++YR+E++KILGKGSFGQVVKAYDHK ++VALKM+RNEKRF +QA EEI+ILE LK QD +N NIVHILE FTFRNHVCMTFELLNINLY LIKKNKFQGFSL LV+KFA+SIL+CLDLLH+NK+IHCDLKPENILLKQQGRSGIKVIDFGSSCY+HQRIYTYIQSRFYRAPEVILG Y++ IDMWSFGCIL E+ TG PLFPGEDE DQLACIIE+LG+PP++ ++ KR+K F S+GYPRYC +E +T+ G I LKG +SKRGKYRG PG+KS+ S+ LK+ ++ F++FL +CL+W+P DR TP+EAL+ EWLRRK P +N
Sbjct: 76 SPLTPDQAMKLYMHRLSTFEHHEIFNYPQIYFVGHNAKKKHGISVGANNNGYDDEHGSYQHVAHDHVSYRYEILKILGKGSFGQVVKAYDHKTGMFVALKMVRNEKRFAKQALEEIKILEQLKIQDKDNNKNIVHILEHFTFRNHVCMTFELLNINLYSLIKKNKFQGFSLLLVKKFAYSILVCLDLLHKNKVIHCDLKPENILLKQQGRSGIKVIDFGSSCYDHQRIYTYIQSRFYRAPEVILGGKYSVQIDMWSFGCILVEMLTGYPLFPGEDEMDQLACIIEVLGMPPQNFLDQCKRSKEFFCSKGYPRYCQLETETETQSGKTIINGVVFYLKGCKSKRGKYRGSPGSKSLASIVNAMNPDLNSDANIDSEIQLKDFTN--FINFLLKCLEWVPDDRFTPKEALRHEWLRRKLPRPPDNN 497 The following BLAST results are available for this feature:
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002728 ID=SMED30002728|Name=Dual specificity tyrosine-phosphorylation-regulated kinase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2101bpback to top protein sequence of SMED30002728-orf-1 >SMED30002728-orf-1 ID=SMED30002728-orf-1|Name=SMED30002728-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=583bp MDKNIYLPWINSGNNNLTNAKSDPQLAAKRNFGNIQNFQYNNINDEMSGEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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