Cathepsin L2

Overview
NameCathepsin L2
Smed IDSMED30002704
Length (bp)1178
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cathepsin L2 (SMED30002704) t-SNE clustered cells

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30002704) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30002704

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 37

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30002704h1SMcG0007334 Contig1337GPL15192PMID:23079596
Forsthoefel et al., 2012
whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30002704h1SMcG0007334 Contig1337GPL15192PMID:23079596
Forsthoefel et al., 2012
whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30002704h1SMcG0007334 Contig1337GPL15192PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30002704h1SMcG0007334 Contig7289newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30002704h1SMcG0007334 Contig7289uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
non-ciliated neuronSMED30002704h1SMcG0007335 dd_Smed_v4_73979_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30002704h1SMcG0007334 dd_Smed_v4_73979_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig32941newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig32941uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig4189uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig4189newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig32104newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig32104uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig9364newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig9364uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
copulatory apparatusSMED30002704h1SMcG0007334 PL030013A20C10smed_ncbi_20240424PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
copulatory apparatusSMED30002704h1SMcG0007334 PL03018A1A09smed_ncbi_20240424PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
reproductive organSMED30002704h1SMcG0007335 Contig13376uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007335 Contig13376newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig12527uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig12527newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig10350uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig10350newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
copulatory apparatusSMED30002704h1SMcG0007334 Contig1337GPL15192PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
reproductive organSMED30002704h1SMcG0007334 Contig8763newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig8763uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig7289newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig7289uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig6059newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig6059uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig18253newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig18253uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig26832newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig26832uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
copulatory apparatusSMED30002704h1SMcG0007334 Contig1344GPL15192PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
reproductive organSMED30002704h1SMcG0007334 Contig19864newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30002704h1SMcG0007334 Contig19864uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 319.701 bits (818), Expect = 4.994e-107
Identity = 170/338 (50.30%), Postives = 215/338 (63.61%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++L+ F + I +   +F  N  L+ +W  +KA   + Y    E  RR +WE+N+  I  HN EY  GKH +T+ +N + D+TN EF+ +++G   N    KG  F  P  +  LP SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTGKL+SLSEQ LVDCSRP GN GC GGF  +AF YV +  G++SE+ Y Y   +  C Y     VAN T +T      E  L  AVATVGP+SV +DA     Q+YK+GIY  P+CSS+ L H VLVVGYG    + N   YW+VKNSWG ++G  GY+ ++KDK+N CGIAT A YP V
Sbjct:    1 MNLSLVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 319.701 bits (818), Expect = 4.994e-107
Identity = 170/338 (50.30%), Postives = 215/338 (63.61%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++L+ F + I +   +F  N  L+ +W  +KA   + Y    E  RR +WE+N+  I  HN EY  GKH +T+ +N + D+TN EF+ +++G   N    KG  F  P  +  LP SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTGKL+SLSEQ LVDCSRP GN GC GGF  +AF YV +  G++SE+ Y Y   +  C Y     VAN T +T      E  L  AVATVGP+SV +DA     Q+YK+GIY  P+CSS+ L H VLVVGYG    + N   YW+VKNSWG ++G  GY+ ++KDK+N CGIAT A YP V
Sbjct:    1 MNLSLVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 308.531 bits (789), Expect = 1.098e-102
Identity = 170/338 (50.30%), Postives = 212/338 (62.72%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG--SLNGDN--YWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   +IL+ F + I +     T +  L  +W  +KA  ++ Y    E  RR +WE+N+  I  HN EY  GKHS+T+ +N + D+T+ EF+  + G + N    KG  F  P    A P SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTG+LISLSEQ LVDCS P GN GC GG    AF YV +  G++SE+ Y Y   E  C Y+    VAN T +    ++ E  L  AVATVGP+SV IDA      +YK GIY  P+CSSE + H VLVVGYG  S   DN  YW+VKNSWG ++G+GGY+ M+KD+ N CGIA+ A YP V
Sbjct:    1 MNPTLILAAFCLGIASA--TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ-NRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 308.531 bits (789), Expect = 1.098e-102
Identity = 170/338 (50.30%), Postives = 212/338 (62.72%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG--SLNGDN--YWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   +IL+ F + I +     T +  L  +W  +KA  ++ Y    E  RR +WE+N+  I  HN EY  GKHS+T+ +N + D+T+ EF+  + G + N    KG  F  P    A P SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTG+LISLSEQ LVDCS P GN GC GG    AF YV +  G++SE+ Y Y   E  C Y+    VAN T +    ++ E  L  AVATVGP+SV IDA      +YK GIY  P+CSSE + H VLVVGYG  S   DN  YW+VKNSWG ++G+GGY+ M+KD+ N CGIA+ A YP V
Sbjct:    1 MNPTLILAAFCLGIASA--TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ-NRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSK (cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536])

HSP 1 Score: 288.115 bits (736), Expect = 9.432e-95
Identity = 154/334 (46.11%), Postives = 208/334 (62.28%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYE-PLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFM-VPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYP 1107
            M    +L L +V+    P        L+  WE++K    KQY   + E+ RR+IWE+NL +I  HNLE  LG H+Y L +N   D+T+ E   K+ G ++  S+S+ ++ + +PE  G  P SVD+R KGYVTPVKNQ  CGSCWAFS+ GALEGQ  +KTGKL++LS Q LVDC     N GCGGG+   AF YV K  G++SED Y Y  +E  C+Y+ +   A    Y    + NE  L  AVA VGP+SV IDA     Q+Y  G+Y + +C+S+ L H VL VGYG   G+ +WI+KNSWG ++G  GYILM+++K+N CGIA  A +P
Sbjct:    1 MWGLKVLLLPVVSFALYPEEI-----LDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 270.396 bits (690), Expect = 3.999e-88
Identity = 143/311 (45.98%), Postives = 202/311 (64.95%), Query Frame = 1
Query:  199 EEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSK---GSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS--LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            E+W+ +K  F K+Y    E      + +N+  I  HN ++ LG+ ++ +GLN  +DL  ++++ KL G R    +S+    S F+ P N+  +P  VDWR    VT VKNQ  CGSCWAFSATGALEGQ+ RK G+L+SLSEQ LVDCS  YGN GC GG   QAF+Y+ + +G+++E+ Y Y+ ++ KC ++K  V A+   Y  T + +E  L  AVAT GP+S+ IDA     Q YK G+Y +  CSSE L H VL+VGYG+   +GD YWIVKNSWG  +G  GYI ++++++N CG+AT+A YP+V
Sbjct:   30 EKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYR-KLNGYRRLFGDSRIKNSSSFLAPFNV-QVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 209.92 bits (533), Expect = 2.117e-66
Identity = 105/198 (53.03%), Postives = 141/198 (71.21%), Query Frame = 1
Query:  529 CGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS--LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            CGSCWAFSATGALEGQ+ RK G+L+SLSEQ LVDCS  YGN GC GG   QAF+Y+ + +G+++E+ Y Y+ ++ KC ++K  V A+   Y  T + +E  L  AVAT GP+S+ IDA     Q YK G+Y +  CSSE L H VL+VGYG+   +GD YWIVKNSWG  +G  GYI ++++++N CG+AT+A YP+V
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 209.92 bits (533), Expect = 2.117e-66
Identity = 105/198 (53.03%), Postives = 141/198 (71.21%), Query Frame = 1
Query:  529 CGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS--LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            CGSCWAFSATGALEGQ+ RK G+L+SLSEQ LVDCS  YGN GC GG   QAF+Y+ + +G+++E+ Y Y+ ++ KC ++K  V A+   Y  T + +E  L  AVAT GP+S+ IDA     Q YK G+Y +  CSSE L H VL+VGYG+   +GD YWIVKNSWG  +G  GYI ++++++N CG+AT+A YP+V
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 172.555 bits (436), Expect = 5.821e-49
Identity = 117/328 (35.67%), Postives = 176/328 (53.66%), Query Frame = 1
Query:  166 PRRFTV-NSELNEEWEIFKAQFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNR-------LNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPN--CSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            PR + + NS L+     F  +  K+Y    EV++R  ++++N   IR+   + + G   Y  G  ++SD+T  EFK  +L  +       +  +N +  +  + E    LP S DWR KG VT VKNQ  CGSCWAFS TG +EG +F    KL+SLSEQ+LVDC     + GC GG P  A+  + +  G+E ED Y Y  +   C +   K +A + + +     +E ++   + T GP+S+G++A    LQ+Y++G+ +     C    L H VL+VGYG      YWIVKNSWG ++G  GY  + + K N CG+   A   +V
Sbjct:  165 PRDYVIWNSFLD-----FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQ-KNEQGTAVY--GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEE--DLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDS--MDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETC-HLVRKDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNANT--LQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597469:1 gene:WBGene00007055.1 transcript:F41E6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 172.555 bits (436), Expect = 5.821e-49
Identity = 117/328 (35.67%), Postives = 176/328 (53.66%), Query Frame = 1
Query:  166 PRRFTV-NSELNEEWEIFKAQFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNR-------LNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPN--CSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            PR + + NS L+     F  +  K+Y    EV++R  ++++N   IR+   + + G   Y  G  ++SD+T  EFK  +L  +       +  +N +  +  + E    LP S DWR KG VT VKNQ  CGSCWAFS TG +EG +F    KL+SLSEQ+LVDC     + GC GG P  A+  + +  G+E ED Y Y  +   C +   K +A + + +     +E ++   + T GP+S+G++A    LQ+Y++G+ +     C    L H VL+VGYG      YWIVKNSWG ++G  GY  + + K N CG+   A   +V
Sbjct:  165 PRDYVIWNSFLD-----FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQ-KNEQGTAVY--GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEE--DLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDS--MDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETC-HLVRKDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNANT--LQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592)

HSP 1 Score: 284.648 bits (727), Expect = 1.505e-93
Identity = 150/316 (47.47%), Postives = 205/316 (64.87%), Query Frame = 1
Query:  199 EEWEIFKAQFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKL------LGNRLNGSNS--KGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS-LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            EEW  FK +  K Y+  TE   R+ I+ EN   I +HN  +  GK S+ L +N+Y+DL + EF+  +      L  +L  ++   KG  F+ P ++  LP SVDWRTKG VT VK+Q  CGSCWAFS+TGALEGQ+FRK+G L+SLSEQ LVDCS  YGN GC GG    AF Y+ +  G+++E  Y Y   ++ C ++K  V A    +T   Q +E  +A AVATVGP+SV IDA     Q+Y  G+YN P C ++ L H VLVVG+G+  +G++YW+VKNSWGT +G  G+I M ++K+NQCGIA+ + YP+V
Sbjct:   27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593)

HSP 1 Score: 285.419 bits (729), Expect = 2.197e-93
Identity = 150/316 (47.47%), Postives = 205/316 (64.87%), Query Frame = 1
Query:  199 EEWEIFKAQFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKL------LGNRLNGSNS--KGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS-LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            EEW  FK +  K Y+  TE   R+ I+ EN   I +HN  +  GK S+ L +N+Y+DL + EF+  +      L  +L  ++   KG  F+ P ++  LP SVDWRTKG VT VK+Q  CGSCWAFS+TGALEGQ+FRK+G L+SLSEQ LVDCS  YGN GC GG    AF Y+ +  G+++E  Y Y   ++ C ++K  V A    +T   Q +E  +A AVATVGP+SV IDA     Q+Y  G+YN P C ++ L H VLVVG+G+  +G++YW+VKNSWGT +G  G+I M ++K+NQCGIA+ + YP+V
Sbjct:   57 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955)

HSP 1 Score: 272.707 bits (696), Expect = 5.818e-89
Identity = 145/308 (47.08%), Postives = 200/308 (64.94%), Query Frame = 1
Query:  223 QFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKL------LGNRLNGSNS--KGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS-LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            +  K Y+  TE   R+ I+ EN   I +HN  +  GK S+ L +N+Y+DL + EF+  +      L  +L  ++   KG  F+ P ++  LP SVDWRTKG VT VK+Q  CGSCWAFS+TGALEGQ+FRK+G L+SLSEQ LVDCS  YGN GC GG    AF Y+ +  G+++E  Y Y   ++ C ++K  V A    +T   Q +E  +A AVATVGP+SV IDA     Q+Y  G+YN P C ++ L H VLVVG+G+  +G++YW+VKNSWGT +G  G+I M ++K+NQCGIA+ + YP+V
Sbjct:   32 EHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021)

HSP 1 Score: 245.358 bits (625), Expect = 1.779e-79
Identity = 122/231 (52.81%), Postives = 161/231 (69.70%), Query Frame = 1
Query:  427 KGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGS-LNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            KG  F+ P ++  LP SVDWRTKG VT VK+Q  CGSCWAFS+TGALEGQ+FRK+G L+SLSEQ LVDCS  YGN GC GG    AF Y+ +  G+++E  Y Y   ++ C ++K  V A    +T   Q +E  +A AVATVGP+SV IDA     Q+Y  G+YN P C ++ L H VLVVG+G+  +G++YW+VKNSWGT +G  G+I M ++K+NQCGIA+ + YP+V
Sbjct:   20 KGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG5367 (gene:FBgn0032228 transcript:FBtr0080055)

HSP 1 Score: 212.616 bits (540), Expect = 1.733e-65
Identity = 119/311 (38.26%), Postives = 181/311 (58.20%), Query Frame = 1
Query:  202 EWEIFKAQFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGA-----LPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            E+E FK   +++Y    + MR    +EEN   I +HN  Y  G+ S+ L  N ++D++   +    L  RL  SN + S   + E +G+     +P S+DWR+KG++TP  NQ +CGSC+AFS   ++ GQ F++TGK++SLS+QQ+VDCS  +GN GC GG       Y+    G+  + DY Y  ++ KC +     V N TS+     R+E  + AAV  +GP+++ I+A     Q Y +GIY++P CSS  + H ++V+G+G     +YWI+KN WG ++G  GYI + K   N CGIA  A Y +V
Sbjct:   35 EFEKFKNNNNRKYLRTYDEMRSYKAFEENFKVIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFL--RLLKSNIEDSADNMAEIVGSPLMANVPESLDWRSKGFITPPYNQLSCGSCYAFSIAESIMGQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVARKGKCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDDPLCSSASVNHAMVVIGFGK----DYWILKNWWGQNWGENGYIRIRKGV-NMCGIANYAAYAIV 338          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52])

HSP 1 Score: 324.709 bits (831), Expect = 3.338e-109
Identity = 169/340 (49.71%), Postives = 225/340 (66.18%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLN-GSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKEN-KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++++L++ A+ A P   +++ +L++ W  +K+Q  K Y    EV RR+IWEENL  I QHN EY LG H++ +G+N++ D+TN EF+  + G + +    S+G  FM P+   A P  VDWR +GYVTPVK+Q  CGSCW+FS+TGALEGQ FRKTGKLIS+SEQ LVDCSRP+GN GC GG   QAF YV +  G++SE  Y Y  +++  C YD    VA  T +    + NE  L  AVA VGP+SV IDA    LQ+Y++GIY    C+S+ L H VLVVGYG     + G+ YWIVKNSW   +G  GYI M+KDK+N CGIAT A YP++
Sbjct:    1 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPKFFAA-PQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQ-LDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52])

HSP 1 Score: 324.709 bits (831), Expect = 3.338e-109
Identity = 169/340 (49.71%), Postives = 225/340 (66.18%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLN-GSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKEN-KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++++L++ A+ A P   +++ +L++ W  +K+Q  K Y    EV RR+IWEENL  I QHN EY LG H++ +G+N++ D+TN EF+  + G + +    S+G  FM P+   A P  VDWR +GYVTPVK+Q  CGSCW+FS+TGALEGQ FRKTGKLIS+SEQ LVDCSRP+GN GC GG   QAF YV +  G++SE  Y Y  +++  C YD    VA  T +    + NE  L  AVA VGP+SV IDA    LQ+Y++GIY    C+S+ L H VLVVGYG     + G+ YWIVKNSW   +G  GYI M+KDK+N CGIAT A YP++
Sbjct:    1 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPKFFAA-PQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQ-LDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctslb (cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285])

HSP 1 Score: 323.939 bits (829), Expect = 7.307e-109
Identity = 168/340 (49.41%), Postives = 220/340 (64.71%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLN-GSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKEN-KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++++L++ A+ A P   +++ +L++ W  +K+Q  K Y    EV RR+IWEENL  I QHN EY  G H++ +G+N++ D+TN EF+  + G   +    S+G  FM P    A P  VDWR +GYVTPVK+Q  CGSCW+FS+TGALEGQ FRKTGKLIS+SEQ LVDCSRP GN GC GG   QAF YV +  G++SE  Y Y  +++  C YD    VA  T +      NE  L  AVA VGP+SV IDA    LQ+Y++GIY    CSS  L H VLVVGYG     + G+ YWIVKNSW   +G  GYI M+KDK+N CG+AT+A YP++
Sbjct:    1 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYTHDPNQTSQGPLFMEPSFFAA-PQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPSGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATKASYPLM 336          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctslb (cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285])

HSP 1 Score: 323.939 bits (829), Expect = 1.210e-108
Identity = 168/340 (49.41%), Postives = 219/340 (64.41%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLG-NRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKEN-KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++++L++ A+ A P   +++ +L++ W  +K+Q  K Y    EV RR+IWEENL  I QHN EY  G H++ +G+N++ D+TN EF+  + G        S+G  FM P    A P  VDWR +GYVTPVK+Q  CGSCW+FS+TGALEGQ FRKTGKLIS+SEQ LVDCSRP GN GC GG   QAF YV +  G++SE  Y Y  +++  C YD    VA  T +      NE  L  AVA VGP+SV IDA    LQ+Y++GIY    CSS  L H VLVVGYG     + G+ YWIVKNSW   +G  GYI M+KDK+N CG+AT+A YP++
Sbjct:   17 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYTHDPNQTSQGPLFMEPSFFAA-PQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPSGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATKASYPLM 352          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: zgc:174153 (zgc:174153 [Source:ZFIN;Acc:ZDB-GENE-080215-7])

HSP 1 Score: 323.168 bits (827), Expect = 1.315e-108
Identity = 168/340 (49.41%), Postives = 219/340 (64.41%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLN-GSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKEN-KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   +I++L + A+   P   +++ +L++ W  +K+Q  K Y    EV RR+IWEENL  I QHN EY  G H++ +G+N++ D+TN EF+  + G + +    S+G  FM P    A P  VDWR +GYVTPVK+Q  CGSCW+FS+TGALEGQ FRKTGKLIS+SEQ LVDCSRP GN GC GG   QAF YV +  G++SE  Y Y  +++  C YD    VA  T +      NE  L  AVA VGP+SV IDA    LQ+Y++GIY    CSS  L H VLVVGYG     + G+ YWIVKNSW   +G  GYI M+KDK+N CG+AT+A YP++
Sbjct:    1 MMFALIITLCISAVFTAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNQTSQGPLFMEPSFFAA-PQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPSGNEPALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATKASYPLM 336          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 325.094 bits (832), Expect = 2.884e-109
Identity = 171/334 (51.20%), Postives = 218/334 (65.27%), Query Frame = 1
Query:  130 ILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENK-CIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            I ++ L  + A P   T +  L+  W ++K    K Y P  E  RR++WE+NL  I  HNLE+ LGKHS++LG+N++ D+TN EF+ +L+    N    +GS F+ P N  + P SVDWR KGYVTPVK+Q  CGSCWAFS TGALEGQ++R TGK+ISLSEQ LVDCSR  GN GC GG   QAF YV +  G++SED Y Y  K+++ C YD +   AN T +      +E DL  AVA+VGP+SV +DA     Q+YK+GIY  P CSSE L H VLVVGYG      +G  YWIVKNSW   +G  GYI ++KD+ N CGIAT A YP+V
Sbjct:    7 IAAICLTTVFAAP---TTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFR-QLMNGYKNQKKIRGSTFLAPNNFES-PKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 325.094 bits (832), Expect = 4.097e-109
Identity = 171/334 (51.20%), Postives = 218/334 (65.27%), Query Frame = 1
Query:  130 ILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENK-CIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            I ++ L  + A P   T +  L+  W ++K    K Y P  E  RR++WE+NL  I  HNLE+ LGKHS++LG+N++ D+TN EF+ +L+    N    +GS F+ P N  + P SVDWR KGYVTPVK+Q  CGSCWAFS TGALEGQ++R TGK+ISLSEQ LVDCSR  GN GC GG   QAF YV +  G++SED Y Y  K+++ C YD +   AN T +      +E DL  AVA+VGP+SV +DA     Q+YK+GIY  P CSSE L H VLVVGYG      +G  YWIVKNSW   +G  GYI ++KD+ N CGIAT A YP+V
Sbjct:   14 IAAICLTTVFAAP---TTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFR-QLMNGYKNQKKIRGSTFLAPNNFES-PKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ano1 (anoctamin 1, calcium activated chloride channel [Source:Xenbase;Acc:XB-GENE-5967576])

HSP 1 Score: 298.13 bits (762), Expect = 1.143e-98
Identity = 152/338 (44.97%), Postives = 212/338 (62.72%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYE-PLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENI---GALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MK+ I L+  L AI     +  +N  L+  W ++K   +K YE  + ++ RRI WE+NL+ +  HNLEY +G H+Y LG+N  +D+T+ E K+KL G  L   + + + F   +N    G +P S+DWR KG V+ VKNQ  CGSCWAFSA GALEGQ   KTGKL+SLS Q LVDCS  YGN GCGGGF  QAF YV +  G++S+  Y Y   + KC YD +   +    YT      E +L  A+ ++GP+SV ID        Y++G+Y++P CS E + H VL VGYG+LNG ++W++KNSWGT YG  GY+ ++++K N CG+A+   YP +
Sbjct:    1 MKSLIFLATVLAAI----VKARINPALDNHWLLWKNTHNKDYEDEIEDLQRRITWEKNLNLVNMHNLEYSMGMHTYELGMNHLADMTSEEIKSKLTGLILPPQSERQATFSSQKNSTFGGKVPDSIDWRDKGCVSDVKNQGGCGSCWAFSAVGALEGQLMLKTGKLVSLSPQNLVDCSSKYGNKGCGGGFMTQAFQYVIDNKGIDSDSYYPYHAMDEKCHYDPTGKASTCAKYTEIVPGTEDNLKQALGSIGPISVAIDGTRPSFFLYRSGVYSDPTCSHE-VNHGVLAVGYGNLNGQDFWLLKNSWGTKYGDQGYVRIARNKGNLCGVASYTCYPEI 333          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433])

HSP 1 Score: 287.73 bits (735), Expect = 1.438e-94
Identity = 147/320 (45.94%), Postives = 201/320 (62.81%), Query Frame = 1
Query:  184 NSELNEEWEIFKAQFHKQYE-PLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGA--------LPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            N  L+ EWEI+K  +HK Y+  + E+MRR+IWE+NL+ IR HNLE+  G H+Y LG+N++ D+T+ E    + G +++         M P N+ +        +P+S+D+R KGYVTP+++Q  CGSCWAFS  GALEGQ  +KTGKL+ +S Q LVDC +   N GCGGG+   AF YV K  G++SE+ Y Y   + KC Y+ S   A    +   K+ +E+ L  AV  VGP+SVGIDA       YK GIY + +C  + + H VL VGYG      YWI+KNSWG D+G  GYILM+++K N CGIA  A YPV+
Sbjct:   21 NGTLDSEWEIWKTTYHKHYDNKIHELMRRLIWEKNLNIIRSHNLEFTQGLHTYELGMNKFGDMTSEEVVRMMTGLKVHTG-------MGPTNLTSDEDEASQRIPNSIDYRKKGYVTPIRDQGECGSCWAFSTVGALEGQLMKKTGKLVGISPQNLVDCVKD--NFGCGGGYMTTAFKYVKKNKGIDSEEAYPYVGMDQKCKYNVSGRAAEIKGFKEVKKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYPVM 331          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216])

HSP 1 Score: 275.404 bits (703), Expect = 7.908e-90
Identity = 146/335 (43.58%), Postives = 206/335 (61.49%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYE-PLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M  F +LS  L  ++ G       S L+ +WE++K  +H+QY   L E+ RR IWE+NL+ I QHN E+  G H+Y L +N   D+T+ E   K++G ++   N + +   +PE    +P  +D+R KGYVTPV NQ  CGSCWAFS+ GALEGQ  +KTGKL+SLS Q LVDC     N GC GG+   AF YV +  G++S+ +Y Y  ++  C Y+ +   A    Y      +E  L  AVA VGP+SV IDA     Q+YK G+Y + +C+ + + H VLVVGYG+  G  +WI+KNSWG  +G  GY+L+++DK N CGIA+ A +PV+
Sbjct:    1 MWWFSLLSFALSLVKIG---LCQESNLDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVP-PNHRPNNTYIPEWNSRIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCDT--DNYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGIASLASFPVM 329          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452])

HSP 1 Score: 295.819 bits (756), Expect = 6.245e-98
Identity = 157/332 (47.29%), Postives = 201/332 (60.54%), Query Frame = 1
Query:  124 FIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG-SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            F++ +L L  + A P     N  L+  WE +K +  K Y    E  +R +WE N   I  HN +Y  GKH ++L +N + DLTN EF+  + G +   +      F  P  +G +P SVDWR  GYVTPVK+Q +CGSCWAFSA G+LEGQ FRKTGKL+ LS Q LVDCS   GN GC GG P  AF YV +  G+++   Y Y      C Y+     A  T +    Q +E  L  AVATVGP+SVGID +    Q+YK G+Y  P+CSS  L H VLVVGYG   +G  YW+VKNSWG D+G+ GYI M+KD++N CGIA+ A YPVV
Sbjct:    5 FLLATLCLGVVSAAPAH---NPSLDAVWEEWKTKHKKTYNMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMKVFQEPL-LGDVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFV-NVQSSEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: BC051665 (cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:2682300])

HSP 1 Score: 295.049 bits (754), Expect = 1.364e-97
Identity = 155/332 (46.69%), Postives = 204/332 (61.45%), Query Frame = 1
Query:  124 FIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG-SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            F++ +L L  + A P     +  L+  WE +K +  K Y    E  +R +WE N+  I  HN +Y  GKH + L +N + DLTN EF+  + G +  G + + + F  P  +G +P SVDWR  GYVTPVK+Q  CGSCWAFSA G+LEGQ FRKTGKL+ LSEQ L+DCS  YGN+GC GG    AF YV +  G+++ + Y Y   +  C YD      N T +      +E  L  AVA+VGP+SVGID      ++Y+ G Y  P+CSS  L H VLVVGYG   +G  YW+VKNSWG D+G+ GYI M+KD+DN CGIAT A+YP V
Sbjct:    5 FLLATLCLGVVSAAPAH---DPSLDAVWEEWKTKHRKTYNMNEEAQKRAVWENNMKMIGLHNEDYLKGKHGFNLEMNAFGDLTNTEFRELMTGFQSMG-HKEMTIFQEPL-LGDVPKSVDWRDHGYVTPVKDQGHCGSCWAFSAVGSLEGQIFRKTGKLVPLSEQNLMDCSWSYGNVGCNGGLMELAFQYVKENRGLDTRESYAYEAWDGPCRYDPKYSAVNITGFVKVP-LSEDALMNAVASVGPVSVGIDTHHHSFRFYRGGTYYEPDCSSTNLDHAVLVVGYGEESDGRKYWLVKNSWGEDWGMDGYIKMAKDRDNNCGIATYAIYPTV 330          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 294.278 bits (752), Expect = 2.671e-97
Identity = 156/312 (50.00%), Postives = 201/312 (64.42%), Query Frame = 1
Query:  193 LNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
             + EW  +K+   + Y    E  RR IWE+N+  I+ HN EY  G+H +++ +N + D+TN EF+  + G R +  + KG  F  P  +  +P SVDWR KG VTPVKNQ  CGSCWAFSA+G LEGQ F KTGKLISLSEQ LVDCS   GN GC GG    AF Y+ +  G++SE+ Y Y  K+  C Y     VAN T +    Q+ E  L  AVATVGP+SV +DA    LQ+Y +GIY  PNCSS+ L H VL+VGYG      N + YW+VKNSWG+++G+ GYI ++KD+DN CG+AT A YPVV
Sbjct:   25 FSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYR-HQKHKKGRLFQEPLML-KIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 294.278 bits (752), Expect = 2.671e-97
Identity = 156/312 (50.00%), Postives = 201/312 (64.42%), Query Frame = 1
Query:  193 LNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
             + EW  +K+   + Y    E  RR IWE+N+  I+ HN EY  G+H +++ +N + D+TN EF+  + G R +  + KG  F  P  +  +P SVDWR KG VTPVKNQ  CGSCWAFSA+G LEGQ F KTGKLISLSEQ LVDCS   GN GC GG    AF Y+ +  G++SE+ Y Y  K+  C Y     VAN T +    Q+ E  L  AVATVGP+SV +DA    LQ+Y +GIY  PNCSS+ L H VL+VGYG      N + YW+VKNSWG+++G+ GYI ++KD+DN CG+AT A YPVV
Sbjct:   25 FSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYR-HQKHKKGRLFQEPLML-KIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Cts8 (cathepsin 8 [Source:MGI Symbol;Acc:MGI:1860275])

HSP 1 Score: 288.5 bits (737), Expect = 5.204e-95
Identity = 147/338 (43.49%), Postives = 209/338 (61.83%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++L++  + +    +  + +  L+ EW+ +K +F+K Y    E  +R +WEEN+  ++QHN+EYD GK ++T+ +N + D+T  E++  L    +   N +  + +     G LP  VDWR +G VTPVKNQ TC SCWAFSA GA+EGQ FRKTGKL+ LS Q LVDCSR  GN GC  G  + A  YV K  G+E+E  Y Y+  +  C Y   +  A  TS++F    +E DL  AVAT+GP+SVGIDAR    + Y+ GIY  P CSS  + H VLVVGYG      +G+ YW++KNS G  +G+ GY+ +++ ++N CGIA+ AVYP V
Sbjct:    1 MGPAVLLAILCLGVAEVTQ--SSDPSLDSEWQEWKRKFNKNYSMEEEGQKRAVWEENMKLVKQHNIEYDQGKKNFTMDVNAFGDMTGEEYRKML--TDIPVPNFRKKKSIHQPIAGYLPKFVDWRKRGCVTPVKNQGTCNSCWAFSAAGAIEGQMFRKTGKLVPLSTQNLVDCSRLEGNFGCFKGSTFLALKYVWKNRGLEAESTYPYKGTDGHCRYHPERSAARITSFSFVSN-SEKDLMRAVATIGPISVGIDARHKSFRLYREGIYYEPKCSSNIINHSVLVVGYGYEGKESDGNKYWLIKNSHGEQWGMNGYMKLARGRNNHCGIASYAVYPRV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|O60911|CATL2_HUMAN (Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 SV=2)

HSP 1 Score: 319.701 bits (818), Expect = 2.398e-106
Identity = 170/338 (50.30%), Postives = 215/338 (63.61%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   ++L+ F + I +   +F  N  L+ +W  +KA   + Y    E  RR +WE+N+  I  HN EY  GKH +T+ +N + D+TN EF+ +++G   N    KG  F  P  +  LP SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTGKL+SLSEQ LVDCSRP GN GC GGF  +AF YV +  G++SE+ Y Y   +  C Y     VAN T +T      E  L  AVATVGP+SV +DA     Q+YK+GIY  P+CSS+ L H VLVVGYG    + N   YW+VKNSWG ++G  GY+ ++KDK+N CGIAT A YP V
Sbjct:    1 MNLSLVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1)

HSP 1 Score: 309.686 bits (792), Expect = 1.899e-102
Identity = 171/338 (50.59%), Postives = 210/338 (62.13%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG--SLNGDN--YWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M    IL+   + I +     T N  L  +W  +KA  ++ Y    E  RR +WE+N+  I  HN EY  GKHS+T+ +N + D+T+ EF+  + G + N    KG  F  P    A P SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTGKL+SLSEQ LVDCS P GN GC GG    AF YV +  G++SE+ Y Y   E  C Y+    VAN T +    ++ E  L  AVATVGP+SV IDA      +YK GIY  P+CSSE + H VLVVGYG  S   DN  YW+VKNSWG ++G+GGYI M+KD+ N CGIA+ A YP V
Sbjct:    1 MNPTFILAALCLGIASA--TLTFNHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQ-NRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2)

HSP 1 Score: 308.531 bits (789), Expect = 5.271e-102
Identity = 170/338 (50.30%), Postives = 212/338 (62.72%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG--SLNGDN--YWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   +IL+ F + I +     T +  L  +W  +KA  ++ Y    E  RR +WE+N+  I  HN EY  GKHS+T+ +N + D+T+ EF+  + G + N    KG  F  P    A P SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTG+LISLSEQ LVDCS P GN GC GG    AF YV +  G++SE+ Y Y   E  C Y+    VAN T +    ++ E  L  AVATVGP+SV IDA      +YK GIY  P+CSSE + H VLVVGYG  S   DN  YW+VKNSWG ++G+GGY+ M+KD+ N CGIA+ A YP V
Sbjct:    1 MNPTLILAAFCLGIASA--TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ-NRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GL24|CATL1_CANLF (Cathepsin L1 OS=Canis lupus familiaris OX=9615 GN=CTSL PE=2 SV=1)

HSP 1 Score: 306.22 bits (783), Expect = 4.480e-101
Identity = 166/338 (49.11%), Postives = 212/338 (62.72%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENK-CIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDN---YWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M   + L+   + I +   +F  +  LN +W  +KA   + Y    E  RR +WE+N+  I  HN EY  GKH +T+ +N + D+TN EF+  + G + N  + KG  F  P     +P SVDWR KGYVTPVKNQ  CGSCWAFSATGALEGQ FRKTGKL+SLSEQ LVDCSR  GN GC GG    AF YV +  G++SE+ Y Y  ++ + C Y      AN T +    QR E  L  AVAT+GP+SV IDA     Q+YK+GIY +P+CSS+ L H VLVVGYG    D+   +WIVKNSWG ++G  GY+ M+KD++N CGIAT A YP V
Sbjct:    1 MNPSLFLTALCLGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQ-NQKHKKGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQR-EKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q28944|CATL1_PIG (Cathepsin L1 OS=Sus scrofa OX=9823 GN=CTSL PE=2 SV=1)

HSP 1 Score: 303.908 bits (777), Expect = 4.196e-100
Identity = 165/339 (48.67%), Postives = 211/339 (62.24%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKE-NKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MK  + L+   + I +   +   N  L+ +W  +KA   + Y    E  RR +WE+N+  I  HN EY  GKH +++ +N + D+TN EF+  + G + N  + KG  F     +  +P SVDWR KGYVT VKNQ  CGSCWAFSATGALEGQ FRKTGKL+SLSEQ LVDCSRP GN GC GG    AF YV +  G+++E+ Y Y  +E N C Y      AN T +    QR E  L  AVATVGP+SV IDA     Q+YK+GIY +P+CSS+ L H VLVVGYG      N   +WIVKNSWG ++G  GY+ M+KD++N CGI+T A YP V
Sbjct:    1 MKPSLFLTALCLGIASAAPKLDQN--LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQ-NQKHKKGKVFH-ESLVLEVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQR-EKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 435.261 bits (1118), Expect = 2.587e-149
Identity = 203/333 (60.96%), Postives = 252/333 (75.68%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MK  ++ S+FLV I+A P +FT+NSELN+EWE++K +F K+YE L E+ RRIIWE NL FI+QHN+EYDLGKH+Y LGLNE++D+T+ EFKAK LG +    N   S F++PENIG LP+ +DWRTKGYVTPVKNQ  CGSCWAFS TG+LEGQ+FRK+GKL+S SEQQLVDCSR + NLGC GG    AF Y+ K+G+E+E  Y Y   +  C YDK+K+V   T +   K  NE+DL AAVAT GP+SV IDA +   Q+Y+ GIYN P+CSS+ L H VL +GYGS N +NYWIVKNSW   +G+ GYI MSKDK NQCGIAT A YP+V
Sbjct:    1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYETLNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLGLKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKFGIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYPLV 333          
BLAST of Cathepsin L2 vs. TrEMBL
Match: I3SRD7 (Uncharacterized protein OS=Lotus japonicus OX=34305 PE=2 SV=1)

HSP 1 Score: 357.451 bits (916), Expect = 9.540e-119
Identity = 175/337 (51.93%), Postives = 230/337 (68.25%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSE---FMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKA   + LF V + + P   T N EL+  W +FK  F KQY    E+ RR+ WE N+  IRQHNLE+DLG H+YTLGLN Y+DLTNAEF   + G R+N S +K +    ++ P  +  LP+SVDWRTKGYVTP+K+Q  CGSCWAFS+TG+LEGQ+F KTG+L+SLSEQ L DCS+  GN+GC GG   QAF Y+ +  G+++E  Y Y+  + KC +  + V A  T YT   Q++E+ L +A+ATVGP+SV IDA     Q Y++G YN   CS+  L H VL VGY S +G +Y+IVKNSWGT +G  GYI M+++K+NQCGIAT + YP V
Sbjct:    1 MKAIAAICLFFVCVYSAP---TFNVELDSHWALFKTTFGKQYSTAEEITRRLAWEANVAIIRQHNLEHDLGLHTYTLGLNNYADLTNAEFNQVMNGLRVNASQTKSANRRTYVAPVGV-ELPTSVDWRTKGYVTPIKDQGQCGSCWAFSSTGSLEGQHFAKTGQLVSLSEQNLTDCSQKQGNMGCNGGLMDQAFTYIKENNGIDTESSYPYKAVDEKCHFKAADVGATDTGYTDIAQQDENALQSAIATVGPISVAIDASHSSFQLYRSGAYNERACSATQLDHGVLAVGYDSEDGKDYYIVKNSWGTSWGQKGYIWMTRNKNNQCGIATMSTYPTV 333          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A267H1I6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013052g1 PE=3 SV=1)

HSP 1 Score: 356.295 bits (913), Expect = 2.251e-118
Identity = 176/334 (52.69%), Postives = 230/334 (68.86%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKA  +++L LVA      +FT+  ELNEEWE +K+   K YE   E+MRR+IWE+NL  I++HNLEYD G HSYTLG+N++ DLT  EFKAK L + +  +  +GS F+   N+G+LP  VDWRTKGYVT VK+Q  CGSCWAFS TG+LEGQ+F+KTG L+SLSEQ LVDCS  +GN+GC GG     F Y+    G+++E  Y Y+ ++ KC +  S V A  + +     +NES L  AVAT+GP+SV IDA     Q YK+G+Y+   CS   L H VL VGYG+  G  YW+VKNSWGT +G+ GYI+MS++K NQCGIA+ A YP+V
Sbjct:    1 MKAAALIALCLVAAATAYPQFTL--ELNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYL-SPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1I8GVB7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 356.295 bits (913), Expect = 2.709e-118
Identity = 176/334 (52.69%), Postives = 230/334 (68.86%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKA  +++L LVA      +FT+  ELNEEWE +K+   K YE   E+MRR+IWE+NL  I++HNLEYD G HSYTLG+N++ DLT  EFKAK L + +  +  +GS F+   N+G+LP  VDWRTKGYVT VK+Q  CGSCWAFS TG+LEGQ+F+KTG L+SLSEQ LVDCS  +GN+GC GG     F Y+    G+++E  Y Y+ ++ KC +  S V A  + +     +NES L  AVAT+GP+SV IDA     Q YK+G+Y+   CS   L H VL VGYG+  G  YW+VKNSWGT +G+ GYI+MS++K NQCGIA+ A YP+V
Sbjct:    1 MKAAALIALCLVAAATAYPQFTL--ELNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYL-SPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: V4AF12 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_117223 PE=3 SV=1)

HSP 1 Score: 345.51 bits (885), Expect = 2.658e-114
Identity = 163/309 (52.75%), Postives = 219/309 (70.87%), Query Frame = 1
Query:  196 NEEWEIFKAQFHKQY--EPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVN-KYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            +EEWE FK+Q  K Y  +  TE  RR +WE+NL FI  HN++ D G HSY LG+N   D+T  E    L G  +  +NS G+ FM P N+G LP++VDWR +GYVTP+K+Q  CGSCW+FSATG+LEGQ+F+KTG+L+SLSEQ LVDCSRP GN+GC GG   QAF Y+    G+++E  Y Y  ++ KC ++++ V A    +T   + +E++L  AVATVGP+SV IDA      +YK+G+Y++P CSS  L H VL VGYG+  G +YW+VKNSWGT +G+ GYI+MS++K+NQCGIAT A YP+V
Sbjct:   12 DEEWEFFKSQHSKMYSDDSYTETYRRSVWEKNLQFINSHNMQADNGMHSYRLGMNHLGDMTREEINKMLNGYTMKTTNSTGATFMPPSNLGDLPTTVDWRKEGYVTPIKDQKQCGSCWSFSATGSLEGQHFKKTGQLVSLSEQNLVDCSRPEGNMGCAGGLMDQAFSYIKMNKGLDTEASYPYTARDGKCHFNRANVGATDVGFTDIPRFSEANLQQAVATVGPVSVAIDASRSTFHFYKSGVYSDPECSSTRLDHGVLAVGYGT-EGSDYWLVKNSWGTVWGMEGYIMMSRNKNNQCGIATSASYPLV 319          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700])

HSP 1 Score: 318.931 bits (816), Expect = 5.465e-107
Identity = 166/337 (49.26%), Postives = 219/337 (64.99%), Query Frame = 1
Query:  124 FIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLN-GSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENK-CIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
              + SL  +    G    +++ +L++ W+++K+   K Y    E  RR++WE+NL  +  HNLE+ +GKH+Y LG+N+++D+TN EF+  + G R N    SKGS F+ P  +  +P  VDWR KGYVTPVK+Q  CGSCWAFS+TGALEGQ+FRKTGKL+SLSEQ LVDCSRP GN GC GG   QAF YV +  G++SE+ Y Y  K+++ C YD +   AN T +       E  L  AVA VGP+SV IDA     Q+Y++GIY    CSSE L H VLVVGYG      +G  YWIVKNSW   +G  GYI M+KD+ N CGIA+ A YP++
Sbjct:    3 LTLASLLALCFCTGFTAPSLDRQLDDHWKLWKSWHSKSYHEKEEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEPSFL-EVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYPLM 338          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000042132.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 301.597 bits (771), Expect = 2.984e-100
Identity = 158/337 (46.88%), Postives = 213/337 (63.20%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLG--NRLNGSNSKGSEFMVPENIGA-LPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M+ F+ ++  +  + A     +++ E + E+  +K +  K Y P  E  R+I W  N   +  HN+  D G  +Y LG+  ++D+ N E++  L G     N + + G+   + +  GA LP++VDWRT+GYVT VKNQ  CGSCWAFSATGALEGQ FRK G L+ LSEQQLVDCSR YGN+GC GG+  QAF YV +  G+++ED Y Y   E  C Y    V A  + Y      +E  L  AVATVGP+SV ID   +  Q Y++G+Y+ P+CS+  LGH VL VGYGS  G +YW+VKNSWGT +G  GYI MS++K+NQCGIAT A YP+V
Sbjct:    1 MRVFLAVATLVAVVGAA----SISME-DLEFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000048039.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 301.597 bits (771), Expect = 2.984e-100
Identity = 158/337 (46.88%), Postives = 213/337 (63.20%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLG--NRLNGSNSKGSEFMVPENIGA-LPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M+ F+ ++  +  + A     +++ E + E+  +K +  K Y P  E  R+I W  N   +  HN+  D G  +Y LG+  ++D+ N E++  L G     N + + G+   + +  GA LP++VDWRT+GYVT VKNQ  CGSCWAFSATGALEGQ FRK G L+ LSEQQLVDCSR YGN+GC GG+  QAF YV +  G+++ED Y Y   E  C Y    V A  + Y      +E  L  AVATVGP+SV ID   +  Q Y++G+Y+ P+CS+  LGH VL VGYGS  G +YW+VKNSWGT +G  GYI MS++K+NQCGIAT A YP+V
Sbjct:    1 MRVFLAVATLVAVVGAA----SISME-DLEFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:103044830])

HSP 1 Score: 300.827 bits (769), Expect = 5.136e-100
Identity = 156/331 (47.13%), Postives = 208/331 (62.84%), Query Frame = 1
Query:  127 IILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVM-RRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            ++  LFL  +  G      +  L++ W+++K + +K Y    E M RR IWE NL  I  HNLE  +  H+Y L +N   DLT  E    + G R+     K S F+    +  +P SVDWR KGYVT VK Q  CGSCWAFSA GALEGQ  R TG+L+SLS Q LVDCS  YGN GC GGF  +AF YV +  G++S+  Y Y   + +C Y+ S   AN TSY+F  + NE  L  AVAT+GP+SV IDA   +   Y++G+Y +P+C+   + H VLVVGYG+LNG++YW+VKNSWGT +G GGYI M+++K N CGIA+   YP++
Sbjct:    1 MLRGLFLTLL-CGAAVALSDPNLDQHWQLWKKKHYKSYSTEVEEMGRREIWERNLQLISLHNLEASMDIHTYDLAMNHMGDLTREEILDMMAGTRVPSHLKKRSSFVSFAGV-QVPDSVDWREKGYVTNVKQQGACGSCWAFSAAGALEGQLMRTTGQLVSLSPQNLVDCSSKYGNKGCHGGFMSRAFQYVIDNGGIDSDASYPYNGMDGQCKYNPSDRAANCTSYSFLPEGNEEALKTAVATIGPVSVAIDATRPQFILYRSGVYYDPSCTKN-VNHGVLVVGYGTLNGEDYWLVKNSWGTGFGDGGYIRMARNKGNMCGIASYCCYPIM 328          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsla (cathepsin L1-like [Source:NCBI gene;Acc:103043056])

HSP 1 Score: 295.819 bits (756), Expect = 5.341e-98
Identity = 164/336 (48.81%), Postives = 205/336 (61.01%), Query Frame = 1
Query:  133 LSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENK-CIY---DKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            L+ F V          ++ +L+  WE FK    K+Y+   E  RR IWE N   I  HN+   LG   Y LG+N + D+TN EFK    G +      + S F+VP+   A P+ VDWR KGYVTPVK+Q  CGSCWAFS TGALEGQ F+KTGKL+SLSEQ LVDCSRP GN GC GG    AF Y+ N+ G+ SE  Y Y   +++ C Y   D S V+ N   +       E+DL   VA +GP+SV IDA     Q+Y++GIYN  +CSS+ L H VLVVGYG     + G  YWIVKNSWG D+G  GYI M+KD+ NQCGIAT A YP++
Sbjct:    3 LAFFAVCFSTVFAASGLDHDLDNNWEQFKKINSKKYQEKEEGWRRGIWENNFKKIVMHNINNSLGIVPYRLGMNRFGDMTNEEFKQIRNGFKQINEKVRRSVFIVPD-FPAAPAQVDWREKGYVTPVKDQGDCGSCWAFSTTGALEGQQFKKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMNLAFQYIQNRGGLNSEGSYPYLGTDDQPCNYNPNDNSAVINN--GFVDISSGTENDLMKTVAAIGPVSVAIDAGHESFQFYQSGIYNEKDCSSDELNHGVLVVGYGFQGEDVEGKRYWIVKNSWGKDWGDDGYIYMAKDQQNQCGIATAASYPLI 335          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 316.62 bits (810), Expect = 1.040e-106
Identity = 171/339 (50.44%), Postives = 219/339 (64.60%), Query Frame = 1
Query:  127 IILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSN----SKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKE-NKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            ++ +L  V   A P     +  L+EEW  +K    K YEP  E  RR+IWE+NL+ I+ HNLE+ LGKH++ +G+N + D+TN EF+ K+  N  +G      SKGS F+VP+N  A P +VDWR KG VT VK+Q  CGSCWAFS TGALEGQ+ RK G+L+SLSEQ LVDCSR  GN GCGGG   QAF YV +  G++SE  Y Y   + +KC YD     AN T +      +E  L  AVA+VGP+SV IDA     Q+Y++G+Y  P+CSS+ L H VLVVGYG      NG  YWIVKNSW   +G  GY+LM+++K N CGIAT A YP+V
Sbjct:    7 LVPALLAVMASATPIH---DPMLDEEWGSWKGFHQKLYEPKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQKM--NGYHGVQPHKVSKGSTFLVPQNYEA-PPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 288.5 bits (737), Expect = 3.065e-96
Identity = 156/301 (51.83%), Postives = 197/301 (65.45%), Query Frame = 1
Query:  232 KQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSN-----SKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGD-NYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            K Y+   E  RR+IWE+NL  I  HNLE+ +GKH++ +G+N + D+T  EF+  +LG  L GSN     S+G+ FM P    A P SVDWR +GYVT VK+Q  CGSCWAFS TG+LEGQ+ RKTG L+SLSEQ LVDCS   GN GC GG    AF Y+ K  G++SE  Y Y  K+  C Y+     A  T +      NE  L  AVA+VGP+S+GIDA     Q Y +GIY++ +CS+  L H VLVVGYG  + +  +WIVKNSWGT +G  GYILM++DKDN CGIAT A YP+V
Sbjct:    1 KTYDQNEEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLG--LRGSNDTSKASRGATFMAPAFFKA-PESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSNN-LDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 280.026 bits (715), Expect = 4.607e-93
Identity = 146/292 (50.00%), Postives = 192/292 (65.75%), Query Frame = 1
Query:  253 EVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNR-LNGSNS--KGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG-SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            E  RRIIWE+NL  I  HNLE+ +GKH++ +G+N++SD+T  EF+  +LG R  NG++   +G+ FM P    A P SVDWR +GYVT +KNQ  CGSCW+FS TG+LEGQ+ RKTG L+SLSEQ LVDCS   GN GC GG    AF+Y+ K  G++SE+ Y Y+ +   C YD     A  T Y    + +E  L  AVA+VGP+SV IDA     Q Y +GIY +  C S ++ H VLVVGYG    G  +W+VKNSWG  +G  GY+ M++D +N CGIAT + YP+V
Sbjct:    4 EGWRRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPAFFEA-PESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMC-SHHIDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYPLV 293          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007755.1 (pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 gene:ENSPMAG00000007008.1 transcript:ENSPMAT00000007755.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 276.559 bits (706), Expect = 4.602e-91
Identity = 144/310 (46.45%), Postives = 204/310 (65.81%), Query Frame = 1
Query:  202 EWEIFKAQFHKQYEPLTE-VMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLG---NRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDY-VNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTK-QRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            +W+ +K+ + K Y    E   RR ++E+NL  + QHNL  D G  S+ LG+N+YSDL   E+  K++G   N  NG+  +G+ F +  ++  LP  VDWR KGYVTPVK Q  CGS WAFSATG+LEGQ+F  TG L SLSEQQLVDC++ Y N GC GG   +A  Y ++  G++SE  Y Y + + KC +  + V    +SY F +   NE  L  AVA+VGP+++ ++A     ++YK+G++N P+C      H +LVVGYGSL+G+++WIVKNSWG D+G  GYI M ++KDNQCGIA+  +YP++
Sbjct:   26 QWDTWKSTYGKHYGSEQEDAHRRDVFEQNLKRVLQHNLLADEGNVSFHLGINKYSDLELHEYHEKVVGRFWNLRNGTRRRGAPFPL-RSMDNLPEQVDWRLKGYVTPVKEQGLCGSSWAFSATGSLEGQHFAATGNLTSLSEQQLVDCTKSYYNNGCNGGRSERALQYIIDNNGIDSELSYPYEHADGKCRFKPANVATKCSSYQFVEPSSNEEVLRQAVASVGPIAIAMNADLDTFKHYKSGLFNEPSCDKS-PNHAMLVVGYGSLSGNDFWIVKNSWGEDWGEKGYIYMIRNKDNQCGIASIGIYPII 333          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008535.1 (pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 gene:ENSPMAG00000007699.1 transcript:ENSPMAT00000008535.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 275.404 bits (703), Expect = 1.914e-90
Identity = 150/341 (43.99%), Postives = 204/341 (59.82%), Query Frame = 1
Query:   94 NRIIFHNMKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKL----LGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKE-NKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGI 1086
             R ++  + A     + LV   A  R    +  L+  WE +   F K Y     + RR+IWEEN+ F+ +HNLE+ LG HSYTLG+N  +DLT  EF+  +     G+R        S F+ PEN   +P S+DWR +G VTP+KNQ  CGSCWAFS+TGALEGQ+ R++G+L+ LSEQ L+DCSRP G  GCGGG+   AF YV ++ G++SE DY Y   + + C YD S++VA  + +    + +E DL  AVA+VGP+SV IDA     Q Y++GIY  P C+   L H VLVVG+G      NG  +WIVKN  G   G   Y+ ++ DK   CG+
Sbjct:    2 QRTVWSRVAAVFACLVALVGALAVSRP---DPALDGHWEAWTVYFKKAYTQTDGIKRRLIWEENMRFVDRHNLEHSLGLHSYTLGMNHLADLTVDEFRKTMNGYRRGSRERHEGHHTSTFLAPENY-EVPQSMDWRDQGLVTPIKNQGQCGSCWAFSSTGALEGQWKRRSGELVPLSEQNLLDCSRPEGTEGCGGGWMDDAFQYVLDQGGIDSESDYPYTATDVDSCHYDPSRMVARISGFVDIHKGSEKDLITAVASVGPVSVAIDAGHQSFQLYESGIYYEPECNCTELDHAVLVVGFGVKGRGENGKKFWIVKNRRGLQCGGEIYLEVAVDKRCFCGL 338          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5])

HSP 1 Score: 323.939 bits (829), Expect = 1.713e-109
Identity = 166/334 (49.70%), Postives = 222/334 (66.47%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKAF+   L  V I    + F+  S+ + +W  +K    K Y    E +RR IW +NL+ +++HN E     HSY L +N ++DLT  EFK + +G R   +++ GS F+   N+  LP+ VDWR KG+VT VKNQ  CGSCWAFS+TG+LEGQ+FRKTGKL+SLSEQ LVDCS+ YGN GC GG    AF Y+ N  G+++E  Y Y  ++ +C +    V A  T YT  ++ +E DL +AVATVGP+SV IDA     Q YK G+Y+ P+CSS  L H VL VGYG+ +G +YW+VKNSWG  +G+ GYI MS++KDNQCGIAT+A YP+V
Sbjct:    1 MKAFLACLLVAVLI---AQCFSELSQ-DRQWHAWKDFHGKTYTGEEEDLRRAIWNDNLEIVKKHNAE----NHSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTFLPLSNV-QLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6])

HSP 1 Score: 306.99 bits (785), Expect = 6.827e-103
Identity = 160/337 (47.48%), Postives = 220/337 (65.28%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRI-IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKG--SEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MK F++L + +    A  R ++V    + EW  +K+   K Y  + E   R+ IW++NL+ I++HN E     HSY + +N   DLT  EF+   LG R + +++K   + +M P N+  +PSSVDW  KGYVT VKNQ  CGSCWAFS TG++EGQ+FRKTG L+SLSEQ L+DCS  YGN GC GG    AF Y+ +  G+++E  Y Y  ++  C +  S V A  T Y    Q +E  L +AVATVGP+SV +DA  W  Q+Y +G+Y+NP CSS  L H VLV+GYG+ NG +YW+VKNSWG  +G+ GYI+MS++K+NQCGIA+ A YP+V
Sbjct:    1 MKVFLVLCVLV----ASSRGWSVRFGQDSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAE----DHSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWATYMPPSNV-KIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDASQW--QFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1])

HSP 1 Score: 304.294 bits (778), Expect = 8.308e-102
Identity = 158/336 (47.02%), Postives = 216/336 (64.29%), Query Frame = 1
Query:  124 FIILSLFLVAIEAGPRRFTVN-SELNEEWEIFKAQFHKQYEPLTEV-MRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSN---SKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYG-MESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
             ++ +  L A+ +G   F V   E  ++W+ +K    K+Y  +TE   R+ IW +NL  I++HN E     HS+TL +N   DLT  EF+    G R + SN    +GS F+ P ++  +P +VDWR +GYVTPVKNQ  CGSCWAFS TG+LEGQ F+KTGKL+SLSEQ LVDCS  YGN GC GG    AF Y+ + G +++E+ Y Y  + ++C + KS + A  T +      +E  L  A  TVGP+SV IDA     Q+Y +G+YNN  CSS  L H VLVVGYG+  G +YW+VKNSWG  +G+ GYI+MS++K+NQCG+AT+A YP+V
Sbjct:    3 LLVAACLLFAVASG---FVVKFDEDEQQWQAWKLFHTKKYTTVTEEGARKAIWRDNLKKIQKHNAE----GHSFTLAMNHLGDLTQDEFRYFYTGMRSHYSNYTKKQGSAFLAPSHV-QVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9])

HSP 1 Score: 285.804 bits (730), Expect = 1.472e-94
Identity = 151/338 (44.67%), Postives = 209/338 (61.83%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTE-VMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNG---SNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYG-MESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            M+A I     L+ I +      +    +  W+ +K+   K+Y    E  MR  IW+ NL  I  HN     GKHS+ L +N   D+T+ E    LLG +L     S  KG+ F+ P N+  +  S+DWR+KGYVTPVKNQ  CGSCWAFS TGALEGQ+FRKTGKL+SLSEQ LVDCS  YGN GC GG    AF Y+ + G +++E  Y Y  K+  C Y+KS + A  T +      +E+ L  A+A+VGP+S+ IDA      +Y  G+Y++P+CSS  L H VL VGYG+ +G +YW+VKNSWG  +G  GYI ++++  ++CG+A++A YP+V
Sbjct:    1 MEAVIFA--VLLCISSALAMPPMEPLQDPNWKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHNE----GKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPANVKVV-DSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO42751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0K3])

HSP 1 Score: 194.897 bits (494), Expect = 8.359e-60
Identity = 117/284 (41.20%), Postives = 166/284 (58.45%), Query Frame = 1
Query:  271 IWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKY-GMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPN--CSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            I+E N+    +   + D G   Y  G   +SDL+  EF+ + +         +  +  +P  +G +P SVDWR KG VTPVKNQ +CGSCWAFS TG +EGQY  KTGKL+SLSEQ+LVDC     + GC GG P  A+  + K  G+ESE DY Y+  ++KC ++K++V     S +    ++E ++AA +A  GP+S+GI+A    +Q+Y  GI +     C+   L H VL+VGYG  NG  YWI+KNSWG  +G  GY L+ +     CG+ T     V+
Sbjct:    3 IFESNMRKAAKMQ-KMDSGTAQY--GPTIFSDLSEEEFRKQKMMPGWGKPLYEMKDAEIP--LGDIPESVDWRDKGVVTPVKNQGSCGSCWAFSTTGNIEGQYAIKTGKLVSLSEQELVDCDTI--DKGCEGGLPSNAYKQIEKLGGLESESDYPYKGADSKCKFNKAEVKVTINS-SVVISKDEKEIAAWLAKNGPISIGINAN--AMQFYMGGIAHPWKIFCNPSSLNHGVLIVGYGVKNGTPYWIIKNSWGPSWGEKGYYLIYRG-GGCCGLNTMCTSAVI 275          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246])

HSP 1 Score: 309.686 bits (792), Expect = 2.165e-103
Identity = 162/319 (50.78%), Postives = 206/319 (64.58%), Query Frame = 1
Query:  178 TVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLG-NRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYV-NKYGMESEDDYIYRNKENK-CIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYG----SLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            T++ +L++ W+++K    K Y    E  RR++WE+NL  I  HNLE+ +GKHSY LG+N + D+T+ EF+  + G  R       GS FM P N    P +VDWR KGYVTPVK+Q  CGSCWAFS TGALEGQ FRKTGKL+SLSEQ LVDCSRP GN GC GG   QAF YV +  G++SED Y Y+  +++ C Y+      N T +       E  L  AVA+VGP+SV IDA     Q+Y++GIY    CSS+ L H VLVVGYG     ++G  YWIVKNSW   +G  G+I M+KD+ N CGIAT A YP+V
Sbjct:   19 TLDPQLDQHWQLWKGWHSKNYHEKEEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEP-NFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYPLV 336          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789])

HSP 1 Score: 297.36 bits (760), Expect = 1.625e-98
Identity = 157/311 (50.48%), Postives = 199/311 (63.99%), Query Frame = 1
Query:  202 EWEIFKAQFHKQYE-PLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNS----KGSEFM-VPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYG-MESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            E+  ++ +F + Y  P  E  RR  W  N   +  HN+  D G  SY LG+  ++D+ N E+K  +    L   N+    +GS F  +PEN   LP++VDWR KGYVT VK+Q  CGSCWAFSATG+LEGQ FRKTGKL+SLSEQQLVDCS  YGN+GCGGG    AF Y+   G +++E+ Y Y  ++ +C Y    V A  T Y      +E  L  AVAT+GP+SVGIDA     Q Y++G+Y+ P CSS  L H VL VGYGS NG +YW+VKNSWG  +G  GYI MSK+K NQCGIAT A YP+V
Sbjct:   30 EFHAWRLKFGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRGSTFFRLPENKD-LPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247])

HSP 1 Score: 284.648 bits (727), Expect = 1.200e-93
Identity = 154/314 (49.04%), Postives = 192/314 (61.15%), Query Frame = 1
Query:  178 TVNSELNEEWEIFKAQFHKQY-EPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNK-YGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
             V S L++ W ++K  + K Y   + E  RR IWEENL+ I  HNLE  LG HSY L +N   DLT  E  A L G        +    +V  N  ++P SVDWR  G VT VK Q  CGSCWAFSA GALEGQ  + TG L SLS Q LVDCS  YGN GC GGF   AF YV K  G+ S+  Y Y  K +KC YD     AN T Y F  + +E  L   VAT+GP+SV IDA   +  +Y++G+Y + +CS   + H VLVVGYG+ NG++YW+VKNSWG  YG GGYI M++++ NQCGIA  A +PV+
Sbjct:   16 AVRSHLDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIASLTGTVAPVGLERIHYDLVKINT-SVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKDHSCSHN-VNHGVLVVGYGTENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFPVM 327          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830])

HSP 1 Score: 282.722 bits (722), Expect = 6.044e-93
Identity = 145/329 (44.07%), Postives = 196/329 (59.57%), Query Frame = 1
Query:  133 LSLFLVAIEAGPRRFTVNSE--LNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            L+  L  +   P+    +S+  +  EWEI+K+     YE   ++ RR IWEEN   I  HN  +  GK  +++G+N+Y DL   E  A+ L  R N   S+                VD+R  GYVT VK+Q  CGSCWAFS TGA+EGQ  +KTG+L+SLSEQ LVDCSRPYG  GC G +   A+DYV   G+++ D Y Y +    C YD    VA+   Y F  Q +E  LA AVAT+GP++V IDA      +Y +GIY+ PNC    L H VL+VGYGS  G +YWI+KNSWG+ +G GGY+ + ++  N CGIA+ A+YP++
Sbjct:   11 LATLLYMLLCSPQHVRSDSDEAVLTEWEIWKSINGINYEERDDMQRRAIWEENHRMINDHNQRFLTGKRPFSMGMNKYGDLRGKEVSARRL--RYNARKSEAG-------------FVDYRNMGYVTEVKDQGYCGSCWAFSTTGAIEGQIVKKTGQLLSLSEQNLVDCSRPYGTHGCSGAWMASAYDYVLSNGLQTTDSYPYTSDTQPCFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGPITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 324          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830])

HSP 1 Score: 281.567 bits (719), Expect = 2.255e-92
Identity = 145/330 (43.94%), Postives = 199/330 (60.30%), Query Frame = 1
Query:  139 LFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENI--GALPSS---VDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            L+++       R   +  +  EWEI+K+     YE   ++ RR IWEEN   I  HN  +  GK  +++G+N+Y DLT  E++  L G  +N    K  + +    +   A  S    VD+R  GYVT VK+Q  CGSCWAFS TGA+EGQ  +KTG+L+SLSEQ LVDCSRPYG  GC G +   A+DYV   G+++ D Y Y +    C YD    VA+   Y F  Q +E  LA AVAT+GP++V IDA      +Y +GIY+ PNC    L H VL+VGYGS  G +YWI+KNSWG+ +G GGY+ + ++  N CGIA+ A+YP++
Sbjct:    6 LYMLLCSPQHVRSDSDEAVLTEWEIWKSINGINYEERDDMQRRAIWEENHRMINDHNQRFLTGKRPFSMGMNKYGDLTGQEYRV-LQGAVMNAQFVKRGKEVSARRLRYNARKSEAGFVDYRNMGYVTEVKDQGYCGSCWAFSTTGAIEGQIVKKTGQLLSLSEQNLVDCSRPYGTHGCSGAWMASAYDYVLSNGLQTTDSYPYTSDTQPCFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGPITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 334          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000013992.1 (SMESG000013992.1)

HSP 1 Score: 664.07 bits (1712), Expect = 0.000e+0
Identity = 319/333 (95.80%), Postives = 323/333 (97.00%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKAFIILSLF VAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEP TEVMRRIIWEENL+ IRQHNLEYDLGKHSYTLGLNEYSDLTN EFKAK LGNRLNGSN KGSEFMVPENIGALPSSVDWRTKGYVTPVK+Q  CGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNL CGGGFP++AFDYVNKYG ESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV
Sbjct:    1 MKAFIILSLFFVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPQTEVMRRIIWEENLELIRQHNLEYDLGKHSYTLGLNEYSDLTNEEFKAKRLGNRLNGSNPKGSEFMVPENIGALPSSVDWRTKGYVTPVKDQGDCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLACGGGFPHKAFDYVNKYGTESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 333          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014171.1 (SMESG000014171.1)

HSP 1 Score: 647.121 bits (1668), Expect = 0.000e+0
Identity = 313/333 (93.99%), Postives = 320/333 (96.10%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKAFIILSLFLVAIEAGPRRFTVNSELNEEWE+FKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQ+FRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTK  NESDLAAAVATVGPLS+GIDA     Q+YKNGIYNNP CSSEYL H VLVVGYGSLNG+NYWIVKNSWG  +GI GYILMSKDKDNQCGIAT+AVYPVV
Sbjct:    1 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKPGNESDLAAAVATVGPLSIGIDADHPGFQHYKNGIYNNPTCSSEYLDHAVLVVGYGSLNGNNYWIVKNSWGPHWGIEGYILMSKDKDNQCGIATQAVYPVV 333          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014016.1 (SMESG000014016.1)

HSP 1 Score: 563.918 bits (1452), Expect = 0.000e+0
Identity = 269/285 (94.39%), Postives = 277/285 (97.19%), Query Frame = 1
Query:  259 MRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MRRIIWE NL+ IRQHNLEYDLGKH+YTLGLN YSDLTN EFKAKLLGN +NGSN KGSEFMVPENIGALPSSVDWRTKGYVTPVK+QYTCGSCWAFSATGALEGQ+FRKTGKLISLSEQQLVDCSRPYGNL CGGG P++AFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGP+SVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV
Sbjct:    1 MRRIIWEGNLELIRQHNLEYDLGKHTYTLGLNGYSDLTNEEFKAKLLGNIMNGSNPKGSEFMVPENIGALPSSVDWRTKGYVTPVKDQYTCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSRPYGNLACGGGLPHKAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPMSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 285          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000013980.1 (SMESG000013980.1)

HSP 1 Score: 559.681 bits (1441), Expect = 0.000e+0
Identity = 279/348 (80.17%), Postives = 294/348 (84.48%), Query Frame = 1
Query:   70 QAYYKTQSNRIIFHNMKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            +AYYK   +        AFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKH+YTLGLNEYSDLTNAEFKAK LGNR+NGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQ  CGSCWAFSATGALEGQ+FRKTGKLISLSEQQLVDCS PY   GC  G P  AF YV  YG+ESE+DY Y     KCIYDKSK VANFTS+T  +  NESDLAAAVATVGP+SV IDA     Q+YK GIYNNP CS   L H VL+VGYGSLNGDN+WIVKNSWG D+GI GYILMSKDKDNQCGIA+ A YPVV
Sbjct:  106 RAYYKQICD-------DAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHTYTLGLNEYSDLTNAEFKAKFLGNRMNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQGDCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSGPY---GCNLGIPVLAFYYVETYGIESEEDYPYCRAVKKCIYDKSKAVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 443          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014167.1 (SMESG000014167.1)

HSP 1 Score: 475.707 bits (1223), Expect = 6.710e-169
Identity = 222/333 (66.67%), Postives = 266/333 (79.88%), Query Frame = 1
Query:  115 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 1113
            MKAF+++S+FLVAI+A    F++NSELN++WE++K QF +QYEPLTE+ RRIIWE+NL++IRQHNLEYDLGKH+Y LGLNEY+DLTN EFKAK LG  L  S+ KGS+FM PEN+GALP++VDWRTKGYVTPVKNQ  CGSCWAFS TG+LEGQ+FRKTG L+S SEQQLVDCS  YGN GCGGG    AF+Y+ KYG+ESE DY Y   + KC YD+SKVV   + +T  K  NESDLA AVATVGP+SV IDA  +  Q YK GIYN P CS + L H VL VGYGS NG NYW+VKNSWG  +G+ GYI MSKD++NQCGI+T A +P+V
Sbjct:    1 MKAFVLISVFLVAIQARRPTFSLNSELNKDWELYKTQFKRQYEPLTEITRRIIWEQNLEYIRQHNLEYDLGKHTYYLGLNEYADLTNEEFKAKFLGKILTRSSRKGSQFMAPENMGALPTTVDWRTKGYVTPVKNQQQCGSCWAFSTTGSLEGQHFRKTGSLVSFSEQQLVDCSGAYGNEGCGGGLMDNAFNYIMKYGLESERDYPYTATDGKCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYGSENGGNYWLVKNSWGISWGLSGYIKMSKDRNNQCGISTSASFPLV 333          
The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CTSV4.994e-10750.30cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSV4.994e-10750.30cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSL1.098e-10250.30cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSL1.098e-10250.30cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSK9.432e-9546.11cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536][more]
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BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cpl-13.999e-8845.98CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-12.117e-6653.03CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-12.117e-6653.03CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
tag-1965.821e-4935.67pep chromosome:WBcel235:V:8594914:8597500:1 gene:W... [more]
tag-1965.821e-4935.67pep chromosome:WBcel235:V:8594914:8597469:1 gene:W... [more]
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BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cp11.505e-9347.47gene:FBgn0013770 transcript:FBtr0087592[more]
Cp12.197e-9347.47gene:FBgn0013770 transcript:FBtr0087593[more]
Cp15.818e-8947.08gene:FBgn0013770 transcript:FBtr0339955[more]
Cp11.779e-7952.81gene:FBgn0013770 transcript:FBtr0304021[more]
CG53671.733e-6538.26gene:FBgn0032228 transcript:FBtr0080055[more]
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BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-239j18.23.338e-10949.71si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
si:dkey-239j18.23.338e-10949.71si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
ctslb7.307e-10949.41cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285][more]
ctslb1.210e-10849.41cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285][more]
zgc:1741531.315e-10849.41zgc:174153 [Source:ZFIN;Acc:ZDB-GENE-080215-7][more]
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BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fcrl22.884e-10951.20Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
fcrl24.097e-10951.20Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
ano11.143e-9844.97anoctamin 1, calcium activated chloride channel [S... [more]
harbi11.438e-9445.94harbinger transposase derived 1 [Source:Xenbase;Ac... [more]
ctsk7.908e-9043.58cathepsin K (pycnodysostosis) [Source:NCBI gene;Ac... [more]
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BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ctsll36.245e-9847.29cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917... [more]
BC0516651.364e-9746.69cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:... [more]
Ctsl2.671e-9750.00cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsl2.671e-9750.00cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Cts85.204e-9543.49cathepsin 8 [Source:MGI Symbol;Acc:MGI:1860275][more]
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BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O60911|CATL2_HUMAN2.398e-10650.30Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 ... [more]
sp|Q9GKL8|CATL1_CHLAE1.899e-10250.59Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CT... [more]
sp|P07711|CATL1_HUMAN5.271e-10250.30Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 ... [more]
sp|Q9GL24|CATL1_CANLF4.480e-10149.11Cathepsin L1 OS=Canis lupus familiaris OX=9615 GN=... [more]
sp|Q28944|CATL1_PIG4.196e-10048.67Cathepsin L1 OS=Sus scrofa OX=9823 GN=CTSL PE=2 SV... [more]
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BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2U8U4472.587e-14960.96Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1[more]
I3SRD79.540e-11951.93Uncharacterized protein OS=Lotus japonicus OX=3430... [more]
A0A267H1I62.251e-11852.69Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8GVB72.709e-11852.69Uncharacterized protein OS=Macrostomum lignano OX=... [more]
V4AF122.658e-11452.75Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
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BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-26g8.55.465e-10749.26cathepsin L1-like [Source:NCBI gene;Acc:103028700][more]
ENSAMXT00000042132.12.984e-10046.88cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
ENSAMXT00000048039.12.984e-10046.88cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
ctss2.15.136e-10047.13cathepsin S [Source:NCBI gene;Acc:103044830][more]
ctsla5.341e-9848.81cathepsin L1-like [Source:NCBI gene;Acc:103043056][more]
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BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000006499.11.040e-10650.44pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 g... [more]
ENSPMAT00000011285.13.065e-9651.83pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gen... [more]
ENSPMAT00000010475.14.607e-9350.00pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 ... [more]
ENSPMAT00000007755.14.602e-9146.45pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 g... [more]
ENSPMAT00000008535.11.914e-9043.99pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 g... [more]
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BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO464651.713e-10949.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO459536.827e-10347.48Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO367278.308e-10247.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458521.472e-9444.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO427518.359e-6041.20Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl2.165e-10350.78cathepsin L [Source:NCBI gene;Acc:100049246][more]
ctsl.11.625e-9850.48cathepsin L1 [Source:NCBI gene;Acc:101171789][more]
ctss1.200e-9349.04cathepsin S [Source:NCBI gene;Acc:100049247][more]
cts126.044e-9344.07cathepsin L1-like [Source:NCBI gene;Acc:101170830][more]
cts122.255e-9243.94cathepsin L1-like [Source:NCBI gene;Acc:101170830][more]
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BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000013992.10.000e+095.80SMESG000013992.1[more]
SMESG000014171.10.000e+093.99SMESG000014171.1[more]
SMESG000014016.10.000e+094.39SMESG000014016.1[more]
SMESG000013980.10.000e+080.17SMESG000013980.1[more]
SMESG000014167.16.710e-16966.67SMESG000014167.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002704 ID=SMED30002704|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1178bp
GAAGATCAAAGGAAGAACCGCTCACATAGGCCCCGCCATGAAAGGAATGT
ATAAACTGACCCTTGATACCAAGCATACTATAAAACTCAAAGTAATCGCA
TCATATTTCATAACATGAAGGCATTCATAATTTTGTCGTTATTCCTTGTT
GCTATTGAGGCTGGGCCAAGGAGATTCACGGTCAACAGTGAGTTGAATGA
AGAATGGGAAATATTCAAAGCCCAATTTCATAAACAGTATGAACCGCTAA
CGGAGGTTATGAGAAGAATCATTTGGGAAGAAAATCTCGACTTCATTAGA
CAACACAATCTTGAATACGATCTCGGAAAACATTCTTACACTTTGGGATT
GAATGAATATTCTGATCTCACTAATGCAGAATTTAAAGCCAAACTTTTAG
GAAACAGATTGAATGGATCAAACTCAAAAGGATCAGAATTTATGGTGCCA
GAAAACATTGGAGCTTTGCCTTCATCTGTGGATTGGAGAACTAAAGGATA
CGTAACCCCTGTGAAAAATCAATATACTTGCGGTTCATGTTGGGCTTTCT
CAGCCACGGGAGCTCTTGAAGGTCAATATTTTCGAAAAACAGGAAAATTA
ATTAGTTTGTCTGAACAGCAACTTGTTGACTGCAGTAGACCATATGGAAA
CCTTGGATGTGGTGGTGGGTTTCCGTATCAGGCGTTTGACTATGTTAATA
AATACGGAATGGAATCCGAGGATGATTATATATATCGTAACAAAGAAAAC
AAATGTATTTATGATAAATCAAAAGTTGTTGCAAATTTCACTTCGTATAC
TTTTACCAAGCAAAGAAACGAATCTGACTTGGCAGCCGCCGTGGCCACAG
TTGGACCTTTGTCTGTAGGCATCGATGCCCGTGATTGGCGTCTTCAATAT
TATAAAAATGGTATTTACAATAACCCCAATTGTTCTTCAGAATACTTAGG
TCATTACGTTTTAGTCGTTGGTTACGGATCACTCAATGGAGATAACTATT
GGATTGTGAAGAACAGTTGGGGAACTGACTATGGAATAGGAGGATACATC
CTCATGTCAAAGGACAAGGACAACCAATGTGGAATTGCTACTCGAGCCGT
TTATCCAGTGGTCTAATATAAACAATTCTTGATTGAATTTATGACTTTTA
TTATTAATAAATAAATAAATTTGCTTTC
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protein sequence of SMED30002704-orf-1

>SMED30002704-orf-1 ID=SMED30002704-orf-1|Name=SMED30002704-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=334bp
MKAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMR
RIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLN
GSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGA
LEGQYFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGME
SEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLS
VGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKN
SWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0000232copulatory apparatus
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR000668Peptidase_C1A_C
IPR013201Prot_inhib_I29
IPR000169Pept_cys_AS
IPR025661Pept_asp_AS
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
Vocabulary: molecular function
TermDefinition
GO:0008234cysteine-type peptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity