Histone-lysine N-methyltransferase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002598 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 21
Homology
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767]) HSP 1 Score: 509.605 bits (1311), Expect = 9.267e-157 Identity = 293/780 (37.56%), Postives = 408/780 (52.31%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTA-SPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK+ +C +C + SG++L+ C G C + FH +CL L + P +K I C++C CF C+ G++ K+ CS CG++YH C+ + I S CP H C AC ++ +RCL CP ++H GD CI AGS ++ +IC H + S S + NV +CF+C GG+L+CCE CPAS H C +I+ + C+DC++G+ Y I W+K+G+YRWWP +I +P + P + H G F V FFG++DYYW+++ FP+ +GD E G T +++ ++K+L+ AAK ++ ES L+ KP Y+ IK N IG V+I + ADL+EIP+C C+P+D+ +PCG SEC+NR L YECHP VC G+ C+NQ F +R YP E+ T+ RGW LRT IKKG FVNEYVGELIDE E R+K+AHE +V+NFYM+ + RIIDAGP N SRFMNHSC+PN TQKW+VNGD R+GLFAL I AG ELTFNYN LG + C CGA NCSGFLG PK+A + +E K++ L+ K+ K++ + C++CG + C + CP+ YHL C++L+ P W CPWH CD+C + FC C S+C H LV S+ E +C + D Sbjct: 699 KKDTVCQIC----ESSGDSLIP-CEGECCKHFHLECLGL------ASLPDSKFI----CMECKTGQHPCFSCKVSGKDVKR-----CSVGACGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSK------------------------------------------------RSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQI-QVADLSEIPRCNCKPADE--NPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEP-----------------------KQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1360
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767]) HSP 1 Score: 508.834 bits (1309), Expect = 5.253e-156 Identity = 296/787 (37.61%), Postives = 418/787 (53.11%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRV-------KLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTA-SPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK+ +C +C + SG++L+ C G C + FH +CL L + P +K I C++C CF C+ G++ K+ CS CG++YH C+ + I S CP H C AC ++ +RCL CP ++H GD CI AGS ++ +IC H ++ F G + +S +K + N+ +++ P+ S S S C GG+L+CCE CPAS H C +I+ + C+DC++G+ Y I W+K+G+YRWWP +I +P + P + H G F V FFG++DYYW+++ FP+ +GD E G T +++ ++K+L+ AAK ++ ES L+ KP Y+ IK N IG V+I + ADL+EIP+C C+P+D+ +PCG SEC+NR L YECHP VC G+ C+NQ F +R YP E+ T+ RGW LRT IKKG FVNEYVGELIDE E R+K+AHE +V+NFYM+ + RIIDAGP N SRFMNHSC+PN TQKW+VNGD R+GLFAL I AG ELTFNYN LG + C CGA NCSGFLG PK+A + +E K++ L+ K+ K++ + C++CG + C + CP+ YHL C++L+ P W CPWH CD+C + FC C S+C H LV S+ E +C + D Sbjct: 699 KKDTVCQIC----ESSGDSLIP-CEGECCKHFHLECLGL------ASLPDSKFI----CMECKTGQHPCFSCKVSGKDVKR-----CSVGACGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIPSSSASKK-----KCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQI-QVADLSEIPRCNCKPADE--NPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEP-----------------------KQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]) HSP 1 Score: 518.079 bits (1333), Expect = 1.686e-154 Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C C FH +CL L ++ P K I C +C + CF+C++ GE+ K+ C CG++YH C+ Y + N+ C HIC C+ +P V + RC+ CP ++H D+C+ AGS+ + N IICP H TP C + V NV+WCF+C +GG L+CC+ CPA+ H+ C ID + C+DC++G+ P Y +I W+K+G YRWWP +I HP P + K H G+F V FFG+NDY W ++ FP+ +GD + +D G G +D Y+K+L+ AA+ L+ K L + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC G C+NQ F +R+YP+ E+F T RGW LRT IKKG FVNEYVGELIDE E R++ A E +++NFYM+ LD RIIDAGP N +RFMNH C PN TQKWSVNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK +E K + + + Q K+ D EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +S+C HR L S + + C+ H+ Sbjct: 1289 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 1937
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]) HSP 1 Score: 518.079 bits (1333), Expect = 1.686e-154 Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C C FH +CL L ++ P K I C +C + CF+C++ GE+ K+ C CG++YH C+ Y + N+ C HIC C+ +P V + RC+ CP ++H D+C+ AGS+ + N IICP H TP C + V NV+WCF+C +GG L+CC+ CPA+ H+ C ID + C+DC++G+ P Y +I W+K+G YRWWP +I HP P + K H G+F V FFG+NDY W ++ FP+ +GD + +D G G +D Y+K+L+ AA+ L+ K L + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC G C+NQ F +R+YP+ E+F T RGW LRT IKKG FVNEYVGELIDE E R++ A E +++NFYM+ LD RIIDAGP N +RFMNH C PN TQKWSVNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK +E K + + + Q K+ D EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +S+C HR L S + + C+ H+ Sbjct: 1289 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 1937
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]) HSP 1 Score: 518.079 bits (1333), Expect = 2.758e-154 Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C C FH +CL L ++ P K I C +C + CF+C++ GE+ K+ C CG++YH C+ Y + N+ C HIC C+ +P V + RC+ CP ++H D+C+ AGS+ + N IICP H TP C + V NV+WCF+C +GG L+CC+ CPA+ H+ C ID + C+DC++G+ P Y +I W+K+G YRWWP +I HP P + K H G+F V FFG+NDY W ++ FP+ +GD + +D G G +D Y+K+L+ AA+ L+ K L + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC G C+NQ F +R+YP+ E+F T RGW LRT IKKG FVNEYVGELIDE E R++ A E +++NFYM+ LD RIIDAGP N +RFMNH C PN TQKWSVNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK +E K + + + Q K+ D EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +S+C HR L S + + C+ H+ Sbjct: 1558 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2206
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: rps-18 (Ribosomal Protein, Small subunit [Source:UniProtKB/TrEMBL;Acc:O18240]) HSP 1 Score: 213.386 bits (542), Expect = 1.061e-63 Identity = 96/135 (71.11%), Postives = 117/135 (86.67%), Query Frame = 1 Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSLI+P+KF HI RVMNTNIDG R + YALTAI+GVGRRFA V C+KA+VDVNKRAGE+T+++ +KI T+M NP+ YKIP WFLNRQ+DIKDG Q+++ +DNKLREDLER+KKI+ HRGLRH+WGLRVRGQH Sbjct: 1 MSLIIPEKFQHIHRVMNTNIDGNRKVPYALTAIKGVGRRFAFVCCRKADVDVNKRAGELTEEDFDKIVTIMQNPSQYKIPNWFLNRQKDIKDGKTGQLLSTAVDNKLREDLERMKKIRLHRGLRHYWGLRVRGQH 135
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: met-1 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:A4LBC2]) HSP 1 Score: 134.806 bits (338), Expect = 2.296e-31 Identity = 84/213 (39.44%), Postives = 123/213 (57.75%), Query Frame = 2 Query: 2192 TEIPQCEC-RPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDN-RGWALRTLEPIKKGAFVNEYVGELIDEAE-ANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVN---GDT-RIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSE 2809 TE CEC R C+D + C+NR ++ EC P C+ C+NQRF +++Y E F T +G LR ++ IKKG F+ EY+GE+++ + R+ K A + + Y+ + G IDA N SRF+NHSC PN +KWSV GD R+G F+ IKAGEE+TF+Y F + G+ C CG+++CSG++G P+ S D + Sbjct: 622 TESLTCECHRTGGNCSD-----NTCVNRAMLTEC-PSSCQV--KCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYLCDT-GVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQFVNYGRDAQQCFCGSASCSGWIGQKPEEFSSDED 825
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: met-1 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:A4LBC2]) HSP 1 Score: 134.42 bits (337), Expect = 2.577e-31 Identity = 84/213 (39.44%), Postives = 123/213 (57.75%), Query Frame = 2 Query: 2192 TEIPQCEC-RPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDN-RGWALRTLEPIKKGAFVNEYVGELIDEAE-ANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVN---GDT-RIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSE 2809 TE CEC R C+D + C+NR ++ EC P C+ C+NQRF +++Y E F T +G LR ++ IKKG F+ EY+GE+++ + R+ K A + + Y+ + G IDA N SRF+NHSC PN +KWSV GD R+G F+ IKAGEE+TF+Y F + G+ C CG+++CSG++G P+ S D + Sbjct: 636 TESLTCECHRTGGNCSD-----NTCVNRAMLTEC-PSSCQV--KCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYLCDT-GVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQFVNYGRDAQQCFCGSASCSGWIGQKPEEFSSDED 839
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: set-12 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:Q21404]) HSP 1 Score: 119.783 bits (299), Expect = 1.685e-28 Identity = 73/194 (37.63%), Postives = 102/194 (52.58%), Query Frame = 2 Query: 2228 KCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNR-GWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGD--TRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASP 2800 KC C T EC N EC P C NC NQRF +R++ E F TDN G LR E I G + EY GE I +AE N+R+K+ + + + Y E+ +D N +RF+NHSC+PN + W+V +G+FA IK GEE+TF+Y + + PC+CG + C G++G P + P Sbjct: 58 KCGTDC-TTEECSNFANHREC-PRGC---SNCENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKLILEYRGEAITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSCNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDYG--TSFRNDQPCQCGEAACRGWIGKPSTSEVP 244
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 103.219 bits (256), Expect = 4.882e-22 Identity = 46/129 (35.66%), Postives = 70/129 (54.26%), Query Frame = 2 Query: 2387 GWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFL 2773 GW L +E I + EY+G+ I A R K + + Y+ +D +IDA N +RF+NHSC PN Y + ++ G+ RI +++ IK GEE+T++Y F + K+ C CGA C G+L Sbjct: 611 GWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYK-FPIEDDKIDCLCGAKTCRGYL 738
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0335014) HSP 1 Score: 357.066 bits (915), Expect = 4.230e-102 Identity = 218/690 (31.59%), Postives = 333/690 (48.26%), Query Frame = 2 Query: 881 FSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCL---------------RLLFDYLTSKEPT-------------TKVINYLKCVDCN-RNVRRCFICQKL---------------GENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQ---CSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV----VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL-VLRTSKWESILNLKN----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSL-GQKKLPCKCGASNCSGFLG 2776 F + P+C C + +G++LV C+ C H DCL + L TSK P+ V L C +CN C IC ++ +D+++ CS CG+ +H++C ++ Q + S CP H+CH C DDP Q S +C+ CP+++H+ CIPAG++ +N IICP+H ++K+ +H NV WC++C GG+L+CCE CP ++H HC IP+ +IC++C+SGR P YG+I W K ++RWWP I+ P P +LK +HG+ F+V+FFGT+D+ W+++ + + +GD G K ++L R+Y ++ A++ L +++ + E + ++ P Y IKTN + +R ++ +L ++ C C P D+ PCGP + C+NR L EC+P C+ G C N+ F +R+ P+ EV + RG+ L EPI G FV EYVGE+I+ AE RR+++ N+Y + ++ IIDAGP N++RFMNHSC PN TQKW+VN R+G+FA+ I ELTFNY + L K C CGA CSG +G Sbjct: 767 FRGLSREPICKYCYQ----AGSDLV-RCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCC--KYWPQASSSKHSAR--CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH--------------------------------------------------NIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCR---NIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK-------------------SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQ--NLEDLSTCNCLPVDE--HPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIG 1371
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0085267) HSP 1 Score: 357.066 bits (915), Expect = 4.433e-102 Identity = 218/690 (31.59%), Postives = 333/690 (48.26%), Query Frame = 2 Query: 881 FSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCL---------------RLLFDYLTSKEPT-------------TKVINYLKCVDCN-RNVRRCFICQKL---------------GENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQ---CSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV----VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL-VLRTSKWESILNLKN----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSL-GQKKLPCKCGASNCSGFLG 2776 F + P+C C + +G++LV C+ C H DCL + L TSK P+ V L C +CN C IC ++ +D+++ CS CG+ +H++C ++ Q + S CP H+CH C DDP Q S +C+ CP+++H+ CIPAG++ +N IICP+H ++K+ +H NV WC++C GG+L+CCE CP ++H HC IP+ +IC++C+SGR P YG+I W K ++RWWP I+ P P +LK +HG+ F+V+FFGT+D+ W+++ + + +GD G K ++L R+Y ++ A++ L +++ + E + ++ P Y IKTN + +R ++ +L ++ C C P D+ PCGP + C+NR L EC+P C+ G C N+ F +R+ P+ EV + RG+ L EPI G FV EYVGE+I+ AE RR+++ N+Y + ++ IIDAGP N++RFMNHSC PN TQKW+VN R+G+FA+ I ELTFNY + L K C CGA CSG +G Sbjct: 771 FRGLSREPICKYCYQ----AGSDLV-RCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCC--KYWPQASSSKHSAR--CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH--------------------------------------------------NIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCR---NIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK-------------------SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQ--NLEDLSTCNCLPVDE--HPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIG 1375
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: RpS18 (gene:FBgn0010411 transcript:FBtr0086274) HSP 1 Score: 197.593 bits (501), Expect = 4.155e-58 Identity = 86/135 (63.70%), Postives = 117/135 (86.67%), Query Frame = 1 Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSL++P+KF HILR+MNTNIDG+R + A+TAI+GVGRR++++V KKA+VD+ KRAGE T++E++K+ T+++NP YK+P WFLNRQ+DI DG Q+ ++ LD+KLR+DLERLKKI+ HRGLRH+WGLRVRGQH Sbjct: 1 MSLVIPEKFQHILRIMNTNIDGKRKVGIAMTAIKGVGRRYSNIVLKKADVDLTKRAGECTEEEVDKVVTIISNPLQYKVPNWFLNRQKDIIDGKYWQLTSSNLDSKLRDDLERLKKIRSHRGLRHYWGLRVRGQH 135
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: RpS18 (gene:FBgn0010411 transcript:FBtr0086273) HSP 1 Score: 197.593 bits (501), Expect = 4.155e-58 Identity = 86/135 (63.70%), Postives = 117/135 (86.67%), Query Frame = 1 Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSL++P+KF HILR+MNTNIDG+R + A+TAI+GVGRR++++V KKA+VD+ KRAGE T++E++K+ T+++NP YK+P WFLNRQ+DI DG Q+ ++ LD+KLR+DLERLKKI+ HRGLRH+WGLRVRGQH Sbjct: 1 MSLVIPEKFQHILRIMNTNIDGKRKVGIAMTAIKGVGRRYSNIVLKKADVDLTKRAGECTEEEVDKVVTIISNPLQYKVPNWFLNRQKDIIDGKYWQLTSSNLDSKLRDDLERLKKIRSHRGLRHYWGLRVRGQH 135
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0073779) HSP 1 Score: 162.925 bits (411), Expect = 8.540e-40 Identity = 81/195 (41.54%), Postives = 113/195 (57.95%), Query Frame = 2 Query: 2243 CGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDS 2827 CG + C+NR LM EC PL C NG C N+RF + + VF T+ +G + I G F+ EYVGE+ID E RR + ++Y M L G+ +IDA NISR++NHSC PN TQKW+VNG+ RIG F++ I+ GEE+TF+Y + G+ C C A+NC G++G P + + + DS Sbjct: 1377 CG--AGCINRMLMIECGPL-CSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDS 1568
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2]) HSP 1 Score: 530.02 bits (1364), Expect = 1.448e-163 Identity = 302/787 (38.37%), Postives = 414/787 (52.60%), Query Frame = 2 Query: 884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN---------KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 S K +C +C ++ D + C G C FHP C L ++ PT K + C +C V CF C++LGE+ + +C CG++YH C + + NR+ CP H C +C+I +P + RC+ CP ++H D+CIPAGS + D+ I+CP H TP C + V NV+WCF+C +GG L+CCE CPA+ H+ C ID + C+DC++G+ P Y ++ W+K+G YRWWP ++ +P + PE +L+ H G+F V FFG+NDY W + FP+ +GD ANS ++ G G +D Y+K+L AA LR + ++ L+ KP Y+ IK N P G V I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC GE C+NQ F++R+Y + E F T +RGW LR + IKKG F++EYVGE+IDE E R+K A E N+ NFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLF+L I AG ELTFNYN LG K CKCGASNCSGFLG PK ++ PSD KK + Q +++ + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +SYC+ HR L S + + CS H+ Sbjct: 716 STSVKENVCPMCEKQGD------LLLCEGQCCGAFHPQCTGL------NEPPTGKFL----CQECTSGVHSCFACKRLGED-----VRRCMVPGCGKFYHGECA--ASHAPTVPLNRA--FRCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHF----------TPRKGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGD----------ANS------KEKMGKG---VDSTYKKALDEAA----LRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIIS-ADLSEIPRCNCKATDE--NPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLGVRPK----NNPPSDDKGRKLKKKRKSQ---------------------QEVIKER--EDECFSCGDGGQIVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQEAASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHD 1379
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2]) HSP 1 Score: 530.406 bits (1365), Expect = 4.453e-161 Identity = 302/787 (38.37%), Postives = 414/787 (52.60%), Query Frame = 2 Query: 884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN---------KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 S K +C +C ++ D + C G C FHP C L ++ PT K + C +C V CF C++LGE ++ +C CG++YH C + + NR+ CP H C +C+I +P + RC+ CP ++H D+CIPAGS + D+ I+CP H TP C + V NV+WCF+C +GG L+CCE CPA+ H+ C ID + C+DC++G+ P Y ++ W+K+G YRWWP ++ +P + PE +L+ H G+F V FFG+NDY W + FP+ +GD ANS ++ G G +D Y+K+L AA LR + ++ L+ KP Y+ IK N P G V I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC GE C+NQ F++R+Y + E F T +RGW LR + IKKG F++EYVGE+IDE E R+K A E N+ NFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLF+L I AG ELTFNYN LG K CKCGASNCSGFLG PK ++ PSD KK + Q +++ + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +SYC+ HR L S + + CS H+ Sbjct: 1091 STSVKENVCPMCEKQGD------LLLCEGQCCGAFHPQCTGL------NEPPTGKFL----CQECTSGVHSCFACKRLGE-----DVRRCMVPGCGKFYHGECA--ASHAPTVPLNRA--FRCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHF----------TPRKGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGD----------ANS------KEKMGKG---VDSTYKKALDEAA----LRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIIS-ADLSEIPRCNCKATDE--NPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLGVRPK----NNPPSDDKGRKLKKKRKSQ---------------------QEVIKER--EDECFSCGDGGQIVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQEAASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHD 1754
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3]) HSP 1 Score: 513.072 bits (1320), Expect = 4.958e-154 Identity = 291/758 (38.39%), Postives = 398/758 (52.51%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C G C FH C+ L ++ P + I C +C V CF+C+K + E+ +C CG++YH +C+ Y + NR C H+C +CYI +P + RC+ CP ++H D+C+ AGS + +N +CP H + P K K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P Y DI W+K+G YRWWP ++ P + PE + + H G+F V FFG+ DY W + FP+ +GD AN+ ++ G G D Y+K+L AA + L+ + + KN KP Y+ IK N IG V I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECH VC GE C+NQ F +R+Y + E+F T +RGW LR++ IKKGAFVNEYVGE+IDE E R+K A + ++ NFYM+ LD RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFAL I G ELTFNYN LG K CKCGA NCSGFLG P ++P D +L++ + K Q+ K+ D EC+ CG + C CP+VYH C++LS P W CPWH C++CGR + +C C SYC HR L S + + CS H+ Sbjct: 1241 CEGQCCGAFHLQCIGL------TETPKGRFI----CQECKMGVHTCFVCKKPDK-----EVRRCMIPVCGKFYHMDCILK--YSPTVAQNRG--FRCSIHVCLSCYITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFT----------------------------------------------PRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGD----------ANN------KEKMGKG---ADAVYKKALNEAADRFRELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIIT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPNCSGFLG-----VRPKNQPPSDDKTRKLRRKVSGKRKS-----------------QSEVTKERED-ECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHREGMLFISKLDGKLSCSEHD 1888
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3]) HSP 1 Score: 513.072 bits (1320), Expect = 5.603e-154 Identity = 291/758 (38.39%), Postives = 398/758 (52.51%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C G C FH C+ L ++ P + I C +C V CF+C+K + E+ +C CG++YH +C+ Y + NR C H+C +CYI +P + RC+ CP ++H D+C+ AGS + +N +CP H + P K K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P Y DI W+K+G YRWWP ++ P + PE + + H G+F V FFG+ DY W + FP+ +GD AN+ ++ G G D Y+K+L AA + L+ + + KN KP Y+ IK N IG V I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECH VC GE C+NQ F +R+Y + E+F T +RGW LR++ IKKGAFVNEYVGE+IDE E R+K A + ++ NFYM+ LD RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFAL I G ELTFNYN LG K CKCGA NCSGFLG P ++P D +L++ + K Q+ K+ D EC+ CG + C CP+VYH C++LS P W CPWH C++CGR + +C C SYC HR L S + + CS H+ Sbjct: 1257 CEGQCCGAFHLQCIGL------TETPKGRFI----CQECKMGVHTCFVCKKPDK-----EVRRCMIPVCGKFYHMDCILK--YSPTVAQNRG--FRCSIHVCLSCYITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFT----------------------------------------------PRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGD----------ANN------KEKMGKG---ADAVYKKALNEAADRFRELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIIT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPNCSGFLG-----VRPKNQPPSDDKTRKLRRKVSGKRKS-----------------QSEVTKERED-ECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHREGMLFISKLDGKLSCSEHD 1904
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 498.819 bits (1283), Expect = 6.397e-152 Identity = 293/784 (37.37%), Postives = 406/784 (51.79%), Query Frame = 2 Query: 884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCL--YNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN-----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 S+ KK+ +C +C + G++LV+ C G C + FHP+C+ + KE T C +C CF C K+ E D M +CS + CGRYYH C+ Y G + + + L CP H C C +D +RC+ CP ++H GD C+ AGS I + IIC H S KNG F+ P N V WCF+C GG+L+CCE CPAS H C I+ ++C +C+SG+ P Y I W+K+G+YRWWP +I +P P + H G F V FFG++DYYW+N+ FP+ + D E G +++ ++K+L+ AAK ++ E+ L+ +P Y+ IK+N P G V+++ ADL+EIP+C C+P+D+ PC S+C+NR L YECHP VC G+ C NQ F +R YP EV T RGW L+T + +KKG FV EYVGELID E +R++ A+E +V+NFYM+ L R+IDAGP N+SRFMNHSCSPN TQKW+VNGD RIGLF L I A ELTFNYN LG + C CG+ NCSGFLG PK+A ++E ++ + KK+ + K+ + CY CG+ + C + CP+ YHL C++LS P W CPWH C C R + FC C S+C H +L S+ ++ CSNH+ Sbjct: 806 SSSKKDTVCHVC----ETFGDSLVS-CEGDCNRLFHPECM----GSNSGKESETV------CQECKTGSHPCFSC-KVTEGD----MKRCSVNGCGRYYHETCVRKYTG------SASDTKGLRCPQHSCATCCLDRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNHSS--------------SRKNGH------------FSSPVN-------------------VGWCFICARGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAE--------------------GQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHV-ADLSEIPRCNCKPTDE--RPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSCHCGSENCSGFLGVKPKSA----------VVMEREEKVRNAKLKPKKRKLKTES------------KQTHELYCYCCGEGGELVMCDKKDCPKAYHLLCLNLSKPPYGRWECPWHQCSVCQRTATSFCHFCPASFCREHERGQLAVSALDKQPCCSNHD 1473
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:NCBI gene;Acc:100145675]) HSP 1 Score: 507.679 bits (1306), Expect = 4.851e-156 Identity = 291/776 (37.50%), Postives = 389/776 (50.13%), Query Frame = 2 Query: 905 LCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALV-LRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 L FL + + E L+ C C FH CL + P K + C +C+ CF+C++ + K+ C CG+YYH C Y NR C HIC CY +P + RC+ CP ++H D+C+PAG+ + N IICP H TP C + V NV+WCF+C +GG L+CCE CPA+ H+ C ID + C+DC++G+ P Y ++ W+K+G YRWWP ++ HP P + K H G+F V FFG+ DY W ++ FP+ +GD + +D G +D Y+K L AA+ L+ K L + KN KP Y+ IK N P+G V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC GE C+NQ F +R+YP+ E+F T +RGW LR IKKG FVNEYVGE+IDE E R++ A E +++NFYM+ LD R+IDAGP N +RFMNH C PN TQKW+VNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK SE K V + K + EC+ CG + C CP+VYH +C+ L+ P W CPWH CD C + + C C +S+C HR L S + + C+ H+ Sbjct: 658 LLFLVVMQVCEKPGELLL-CEAQCCGAFHLQCLGM------EAMPQGKFV----CTECSSGYHTCFVCKESDQGVKR-----CMLPLCGKYYHEECALK--YPPATQQNRG--FRCSLHICSTCYATNPSNPSASKGRLMRCVRCPIAYHANDFCLPAGAVTLASNSIICPNHF----------TPRRGCKNHEHV-----------------------------------NVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCKAGKKPHYKEVVWVKVGRYRWWPAEVCHPKTIPPNIQKMKHDIGEFPVVFFGSKDYLWTHQARVFPYMEGD----------------ALNKDKMSKG---MDAVYKKGLMEAAERFEELKAQKEMRQLQEDKKNDKKPPPYKHIKVNRPVGKVQI-LTADLSEIPRCNCKATDE--NPCGQDSECINRMLLYECHPSVCPAGERCQNQAFSKRQYPEVEIFRTLSRGWGLRCRTDIKKGEFVNEYVGEMIDEEECRARIRYAQEQDITNFYMLTLDKDRVIDAGPKGNFARFMNHCCQPNCETQKWTVNGDTRVGLFALCDIKAGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPVSSEDKGKK-------------------------RKQYVKRKKSEVVKEHEDECFSCGDGGQLVSCKKPGCPKVYHAECLKLTRRPAGKWECPWHQCDICHKEAASLCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 1321
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:100125213]) HSP 1 Score: 504.597 bits (1298), Expect = 1.033e-155 Identity = 283/781 (36.24%), Postives = 394/781 (50.45%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK +C +C + D + C G C FH C+ L S P K + C +C R CF+C++ + K+ C +CG++YH +CL L + G CP H C CY +P + VRC+ CP ++H + CI AG + IIC H + +K+KSH NV+WCF+C +GG L+CCE CPA+ H C I+ + C+DC+ G+ PR+ DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + +G + + ++ +L+ A ++R + + + KP Y+ IK N P G V++ AD++EIP+C C+PS + PCG SEC+NR LMYECHP VC G+ C+NQ F +R+YP+ ++ T+ +GW L IKKG FVNEY+GELIDE E R++ A E ++++FYM+ +D RIIDAGP N SRFMNHSC PN TQKWSVNGDTR+GLFA+ I AGEELTFNYN LG +K C+CGA NCSGFLGD PK +S E K + K+ ++ KK + C+RC + C + C + YHL C+SL+ P W CPWH CD CG+ S CS C S+C H + + E +C D Sbjct: 615 KKELVCQVCEKVGD------LMLCEGVCCSAFHLSCIGL------STRPAGKYL----CKECTSGARSCFLCKESNRDVKR-----CIVPHCGKFYHESCLRK---YPLAVFESRG-FRCPLHRCATCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFA-------------------------------------------------ANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYT-ADISEIPKCNCKPSSE--KPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKVSSSHEEKVKKPKKKQKKRRTKTDG------------------------KKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD 1275
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:100125213]) HSP 1 Score: 503.056 bits (1294), Expect = 1.216e-155 Identity = 284/783 (36.27%), Postives = 395/783 (50.45%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPK--TASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK +C +C + D + C G C FH C+ L S P K + C +C R CF+C+ + ++ +C +CG++YH +CL L + G CP H C CY +P + VRC+ CP ++H + CI AG + IIC H + +K+KSH NV+WCF+C +GG L+CCE CPA+ H C I+ + C+DC+ G+ PR+ DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + +G + + ++ +L+ A ++R + + + KP Y+ IK N P G V++ AD++EIP+C C+PS + PCG SEC+NR LMYECHP VC G+ C+NQ F +R+YP+ ++ T+ +GW L IKKG FVNEY+GELIDE E R++ A E ++++FYM+ +D RIIDAGP N SRFMNHSC PN TQKWSVNGDTR+GLFA+ I AGEELTFNYN LG +K C+CGA NCSGFLGD PK TAS E K + K+ ++ KK + C+RC + C + C + YHL C+SL+ P W CPWH CD CG+ S CS C S+C H + + E +C D Sbjct: 552 KKELVCQVCEKVGD------LMLCEGVCCSAFHLSCIGL------STRPAGKYL----CKECTSGARSCFLCK-----ESNRDVKRCIVPHCGKFYHESCLRK---YPLAVFESRG-FRCPLHRCATCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFA-------------------------------------------------ANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYT-ADISEIPKCNCKPSSE--KPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVKKPKKKQKKRRTKTDG------------------------KKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD 1214
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 500.36 bits (1287), Expect = 2.006e-155 Identity = 289/767 (37.68%), Postives = 398/767 (51.89%), Query Frame = 2 Query: 935 ESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPK-TASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 ES + +C G C + FH +CL + D L P K I C++C + CF C+ + K+ CS CG++YH C Q T S CP H C +C D + + C + C+ CP ++H GD CI AGS ++ + IIC H G A S S NV +CF+C GGKL+CC+ CPA+ H C ++ + C+DC+SG+ Y I W+K+G+YRWWP +I +P + P + H G F V FFG++DYYW+++ FP+ +GD + +G T +++ ++K+L+ AA+ ++ ES L+ KP Y+ IK+N P+G V+I + ADL+EIP+C CRP+D + PCG +EC+NR L+YECHP +C GE+C NQ F +R YP+ E+F T+ RGW LRT I+KG FVNEYVGELIDE E +R+K+AHE +NFY++ + RIIDAGP N SRFMNHSC+PN TQKW+VNGD R+GLFAL I G ELTFNYN LG + C CGA NCSGFLG PK T + +E K++ L+ KK QK++ + C+RCG + C + CP+ YHL C++L+ P W CPWH CD CG S FC C S+C H L S+ E C + D Sbjct: 496 ESYGESLVSCDGECSRLFHLECLGM--DTL----PDGKFI----CMECKTGLHTCFSCKIPSTSVKR-----CSAPCCGKFYHETCAR----QYSATIFDSKGFRCPHHCCSSCTADK-DPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHA-----------------------------------------------SSSVNVGFCFVCARGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDK--------------------SFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQI-QLADLSEIPRCNCRPTD--DTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRECHCGAENCSGFLGVRPKVTCATATEERSKNARLKAKKRKLKTE-----------------------QKQMHEDFCFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREHEKGSLTSSALEGRFCCSDHD 1149
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:100125213]) HSP 1 Score: 503.056 bits (1294), Expect = 4.092e-155 Identity = 284/783 (36.27%), Postives = 395/783 (50.45%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPK--TASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK +C +C + D + C G C FH C+ L S P K + C +C R CF+C+ + ++ +C +CG++YH +CL L + G CP H C CY +P + VRC+ CP ++H + CI AG + IIC H + +K+KSH NV+WCF+C +GG L+CCE CPA+ H C I+ + C+DC+ G+ PR+ DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + +G + + ++ +L+ A ++R + + + KP Y+ IK N P G V++ AD++EIP+C C+PS + PCG SEC+NR LMYECHP VC G+ C+NQ F +R+YP+ ++ T+ +GW L IKKG FVNEY+GELIDE E R++ A E ++++FYM+ +D RIIDAGP N SRFMNHSC PN TQKWSVNGDTR+GLFA+ I AGEELTFNYN LG +K C+CGA NCSGFLGD PK TAS E K + K+ ++ KK + C+RC + C + C + YHL C+SL+ P W CPWH CD CG+ S CS C S+C H + + E +C D Sbjct: 609 KKELVCQVCEKVGD------LMLCEGVCCSAFHLSCIGL------STRPAGKYL----CKECTSGARSCFLCK-----ESNRDVKRCIVPHCGKFYHESCLRK---YPLAVFESRG-FRCPLHRCATCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFA-------------------------------------------------ANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYT-ADISEIPKCNCKPSSE--KPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVKKPKKKQKKRRTKTDG------------------------KKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD 1271
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574]) HSP 1 Score: 507.679 bits (1306), Expect = 2.628e-156 Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250 KK +C LC +++G+ L+ C G C FH CL L S+ P + C +C + CF+C+ + K E+ +C + CG++YH C+ + +T S CP H C +C+ +P + + RC+ CP ++H GD C+ AG I N IIC H + + G+ VN V+WCF+C GG L+CCE CPA+ H C I+ + C+DC++G+ + DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + G + R ++ +L+ A V + + KP Y+ IK N P G V+I AD++EIP+C C+P+D+ +PCG SEC+NR LM+ECHP VC GE C+NQ F +R+YP+ ++ TD +GW L I+KG FVNEYVGELIDE E R+K AHE ++++FYM+ +D RIIDAGP N SRFMNHSC PN T KW+VNGDTR+GLFA+ I AG ELTFNYN LG +K C+CGASNCSGFLGD PKT AS SE K + + ++ K+ + EC+RCG + C + C + YHL C+ L P W CPWH CD CG+ S FC C S+C H+ +S+ + DL S T+++ Sbjct: 666 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1340
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574]) HSP 1 Score: 507.679 bits (1306), Expect = 2.628e-156 Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250 KK +C LC +++G+ L+ C G C FH CL L S+ P + C +C + CF+C+ + K E+ +C + CG++YH C+ + +T S CP H C +C+ +P + + RC+ CP ++H GD C+ AG I N IIC H + + G+ VN V+WCF+C GG L+CCE CPA+ H C I+ + C+DC++G+ + DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + G + R ++ +L+ A V + + KP Y+ IK N P G V+I AD++EIP+C C+P+D+ +PCG SEC+NR LM+ECHP VC GE C+NQ F +R+YP+ ++ TD +GW L I+KG FVNEYVGELIDE E R+K AHE ++++FYM+ +D RIIDAGP N SRFMNHSC PN T KW+VNGDTR+GLFA+ I AG ELTFNYN LG +K C+CGASNCSGFLGD PKT AS SE K + + ++ K+ + EC+RCG + C + C + YHL C+ L P W CPWH CD CG+ S FC C S+C H+ +S+ + DL S T+++ Sbjct: 666 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1340
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574]) HSP 1 Score: 507.294 bits (1305), Expect = 3.005e-156 Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250 KK +C LC +++G+ L+ C G C FH CL L S+ P + C +C + CF+C+ + K E+ +C + CG++YH C+ + +T S CP H C +C+ +P + + RC+ CP ++H GD C+ AG I N IIC H + + G+ VN V+WCF+C GG L+CCE CPA+ H C I+ + C+DC++G+ + DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + G + R ++ +L+ A V + + KP Y+ IK N P G V+I AD++EIP+C C+P+D+ +PCG SEC+NR LM+ECHP VC GE C+NQ F +R+YP+ ++ TD +GW L I+KG FVNEYVGELIDE E R+K AHE ++++FYM+ +D RIIDAGP N SRFMNHSC PN T KW+VNGDTR+GLFA+ I AG ELTFNYN LG +K C+CGASNCSGFLGD PKT AS SE K + + ++ K+ + EC+RCG + C + C + YHL C+ L P W CPWH CD CG+ S FC C S+C H+ +S+ + DL S T+++ Sbjct: 665 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1339
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 506.523 bits (1303), Expect = 1.207e-155 Identity = 292/779 (37.48%), Postives = 404/779 (51.86%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK+ +C +C +++G+ LVA C G C + FH +CL L T + C +C CF C+ G++ K+ CS S CG++YH C+ + I S CP H C +C ++ +RCL CP ++H GD C+ AGS ++ + +IC H + S+S + NV +CF+C GG+L+CCE CPAS H C +ID + C+DC++G+ Y I W+K+G+YRWWP +I P + P + H G F V FFG++DYYW+++ FP+ +GD E G T +++ ++K+L+ AAK ++ ES L+ KP Y+ IK N IG V++ + ADL+EIP+C C+P D+ +PCG S+C+NR YECHP VC G+ C+NQ F +R YP EV T+ RGW LRT IKKG FVNEYVGELIDE E R+K+AHE +V+NFYM+ + RIIDAGP N SRFMNHSC+PN TQKW+VNGD R+GLFAL I AG ELTFNYN LG + C CGA NCSGFLG PK+A S +K +LKK + K + + C++CG + C + CP+ YHL C++L+ P W CPWH CD+CG ++ FC C S+C H LV S+ E +C + D Sbjct: 709 KKDTVCQVC----EKAGDCLVA-CEGECCRHFHVECLGL----------TAVPEGHFTCEECETGQHPCFSCKVSGKDVKR-----CSVSVCGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSK------------------------------------------------RSSQSAAINVGFCFVCARGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQV-QVADLSEIPRCNCKPGDE--NPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSAC-TSAVDEKTKNAKLKKRRKVKAEA----------------------KPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLCCSSHD 1369
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd1 (nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545]) HSP 1 Score: 521.161 bits (1341), Expect = 1.286e-155 Identity = 299/757 (39.50%), Postives = 397/757 (52.44%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C C FH +CL L + P K I C +C+ + CF+C++ GE+ K+ C CG++YH C+ Y +T N+ CP HIC C+ +P V + RC+ CP ++H D+C+ AGS+ + N IICP H TP C + V NV+WCF+C +GG L+CC+ CPA+ H+ C ID + C+DC++G+ P Y +I W+K+G YRWWP +I HP P + K H G+F V FFG+NDY W ++ FP+ +GD + +D G G +D Y+K+L+ AA+ L+ K L + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC G C+NQ F +R+YP E+F T RGW LRT IKKG FVNEYVGELIDE E R++ A E +++NFYM+ LD RIIDAGP N +RFMNH C PN TQKWSVNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK +E + + S Q K+ D EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +S+C HR L S + + C+ H+ Sbjct: 1456 CEAQCCGAFHLECLGL------PEMPRGKFI----CNECHTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVTQNKG--FRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRS---------------------QGEVTKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2104
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q8BVE8|NSD2_MOUSE (Histone-lysine N-methyltransferase NSD2 OS=Mus musculus OX=10090 GN=Nsd2 PE=1 SV=2) HSP 1 Score: 507.294 bits (1305), Expect = 2.102e-155 Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250 KK +C LC +++G+ L+ C G C FH CL L S+ P + C +C + CF+C+ + K E+ +C + CG++YH C+ + +T S CP H C +C+ +P + + RC+ CP ++H GD C+ AG I N IIC H + + G+ VN V+WCF+C GG L+CCE CPA+ H C I+ + C+DC++G+ + DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + G + R ++ +L+ A V + + KP Y+ IK N P G V+I AD++EIP+C C+P+D+ +PCG SEC+NR LM+ECHP VC GE C+NQ F +R+YP+ ++ TD +GW L I+KG FVNEYVGELIDE E R+K AHE ++++FYM+ +D RIIDAGP N SRFMNHSC PN T KW+VNGDTR+GLFA+ I AG ELTFNYN LG +K C+CGASNCSGFLGD PKT AS SE K + + ++ K+ + EC+RCG + C + C + YHL C+ L P W CPWH CD CG+ S FC C S+C H+ +S+ + DL S T+++ Sbjct: 665 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1339
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q9BZ95|NSD3_HUMAN (Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1) HSP 1 Score: 508.834 bits (1309), Expect = 2.522e-155 Identity = 296/787 (37.61%), Postives = 418/787 (53.11%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRV-------KLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTA-SPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 KK+ +C +C + SG++L+ C G C + FH +CL L + P +K I C++C CF C+ G++ K+ CS CG++YH C+ + I S CP H C AC ++ +RCL CP ++H GD CI AGS ++ +IC H ++ F G + +S +K + N+ +++ P+ S S S C GG+L+CCE CPAS H C +I+ + C+DC++G+ Y I W+K+G+YRWWP +I +P + P + H G F V FFG++DYYW+++ FP+ +GD E G T +++ ++K+L+ AAK ++ ES L+ KP Y+ IK N IG V+I + ADL+EIP+C C+P+D+ +PCG SEC+NR L YECHP VC G+ C+NQ F +R YP E+ T+ RGW LRT IKKG FVNEYVGELIDE E R+K+AHE +V+NFYM+ + RIIDAGP N SRFMNHSC+PN TQKW+VNGD R+GLFAL I AG ELTFNYN LG + C CGA NCSGFLG PK+A + +E K++ L+ K+ K++ + C++CG + C + CP+ YHL C++L+ P W CPWH CD+C + FC C S+C H LV S+ E +C + D Sbjct: 699 KKDTVCQIC----ESSGDSLIP-CEGECCKHFHLECLGL------ASLPDSKFI----CMECKTGQHPCFSCKVSGKDVKR-----CSVGACGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIPSSSASKK-----KCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQI-QVADLSEIPRCNCKPADE--NPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEP-----------------------KQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O88491|NSD1_MOUSE (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Mus musculus OX=10090 GN=Nsd1 PE=1 SV=1) HSP 1 Score: 522.316 bits (1344), Expect = 3.899e-155 Identity = 298/757 (39.37%), Postives = 396/757 (52.31%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C C FH +CL L + P K I C +C+ + CF+C++ GE+ K+ C CG++YH C+ Y +T N+ CP HIC C+ +P V + RC+ CP ++H D+C+ AGS+ + N IICP H TP C + V NV+WCF+C +GG L+CC+ CPA+ H+ C ID + C+DC++G+ P Y +I W+K+G YRWWP +I HP P + K H G+F V FFG+NDY W ++ FP+ +GD + +D G G +D Y+K+L+ AA + L R + + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC G C+NQ F +R+YP E+F T RGW LRT IKKG FVNEYVGELIDE E R++ A E +++NFYM+ LD RIIDAGP N +RFMNH C PN TQKWSVNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK +E + + S Q K+ D EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +S+C HR L S + + C+ H+ Sbjct: 1456 CEAQCCGAFHLECLGL------PEMPRGKFI----CNECHTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVTQNKG--FRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKARKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRS---------------------QGEVTKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2104
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q96L73|NSD1_HUMAN (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1) HSP 1 Score: 518.079 bits (1333), Expect = 1.325e-153 Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C C FH +CL L ++ P K I C +C + CF+C++ GE+ K+ C CG++YH C+ Y + N+ C HIC C+ +P V + RC+ CP ++H D+C+ AGS+ + N IICP H TP C + V NV+WCF+C +GG L+CC+ CPA+ H+ C ID + C+DC++G+ P Y +I W+K+G YRWWP +I HP P + K H G+F V FFG+NDY W ++ FP+ +GD + +D G G +D Y+K+L+ AA+ L+ K L + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ +PCG SEC+NR L+YECHP VC G C+NQ F +R+YP+ E+F T RGW LRT IKKG FVNEYVGELIDE E R++ A E +++NFYM+ LD RIIDAGP N +RFMNH C PN TQKWSVNGDTR+GLFAL IKAG ELTFNYN LG K CKCGA NCSGFLG PK +E K + + + Q K+ D EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +S+C HR L S + + C+ H+ Sbjct: 1558 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2206
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O96028|NSD2_HUMAN (Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1) HSP 1 Score: 501.516 bits (1290), Expect = 3.256e-153 Identity = 280/763 (36.70%), Postives = 392/763 (51.38%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHR 3157 KK +C LC ++ G+ L+ C G C FH CL L S+ P + C +C + CF+C+ + K ++ +C + CG++YH C+ + +T S CP H C +C+ +P + + RC+ CP ++H GD C+ AG I N IIC H + K K H NV+WCF+C GG L+CCE CPA+ H C I+ + C+DC++G+ + DI W+K+G+YRWWP ++ HP N P + K H G+F V FFG+ DYYW ++ FP+ +GD R + G + R ++ +L+ A + + L+ E+ + KP Y+ IK N P G V+I AD++EIP+C C+P+D+ +PCG SEC+NR LM+ECHP VC GE C+NQ F +R+YP+ ++ TD +GW L I+KG FVNEYVGELIDE E R+K AHE ++++FYM+ +D RIIDAGP N SRFMNHSC PN T KW+VNGDTR+GLFA+ I AG ELTFNYN LG +K C+CGASNCSGFLGD PKT++ S + + + + K+ + EC+RCG + C + C + YHL C+ L P W CPWH CD CG+ S FC C S+C H+ Sbjct: 665 KKEYVCQLC----EKPGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCSECASGIHSCFVCK-----ESKTDVKRCVVTQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFT-------------------------------------------------ARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARET-QESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEG----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQ 1308
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A267ERM7 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig026212g1 PE=4 SV=1) HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0 Identity = 325/820 (39.63%), Postives = 445/820 (54.27%), Query Frame = 2 Query: 851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256 FEFQ L L S+ K+ P+C C E G ++ C QFH CL + KC DC + CF+C K DK+ M++C + CG+ YH C + + ++ S L CP H C AC +D P + S VRC+ CP+++H GD+C+PAGS E+++ I+CP+HL + +K+ NV WCF+C GG L+CCERCPAS H C + E+P F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP + + +H G F V FFGT++YYW++K F FEDGD G+++K G+++L + +++ +++A +A L E+ + KP Y+ I+TN P GN R+ K ADL+E+ +C+C S +PCG S+CMNR L YECHP +C + C NQRF++REYP Q VF T+ RGW L+ ++ I KG FVNEYVG+LIDE EA +RL AH+ V+NFYM+ LD RIIDAGP N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL IKAGEELTFNYNF LG +KL C+CGA NCSGFLG P++++ + S + K++ + T K + + CYRC I C + CP+VYHL C+ LS P W CPWH CD+CGR + CSEC SYC H +R+ + VC H+DL +++ + +NG Sbjct: 335 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1064
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A1I8IAL6 (Histone-lysine N-methyltransferase OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0 Identity = 325/820 (39.63%), Postives = 445/820 (54.27%), Query Frame = 2 Query: 851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256 FEFQ L L S+ K+ P+C C E G ++ C QFH CL + KC DC + CF+C K DK+ M++C + CG+ YH C + + ++ S L CP H C AC +D P + S VRC+ CP+++H GD+C+PAGS E+++ I+CP+HL + +K+ NV WCF+C GG L+CCERCPAS H C + E+P F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP + + +H G F V FFGT++YYW++K F FEDGD G+++K G+++L + +++ +++A +A L E+ + KP Y+ I+TN P GN R+ K ADL+E+ +C+C S +PCG S+CMNR L YECHP +C + C NQRF++REYP Q VF T+ RGW L+ ++ I KG FVNEYVG+LIDE EA +RL AH+ V+NFYM+ LD RIIDAGP N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL IKAGEELTFNYNF LG +KL C+CGA NCSGFLG P++++ + S + K++ + T K + + CYRC I C + CP+VYHL C+ LS P W CPWH CD+CGR + CSEC SYC H +R+ + VC H+DL +++ + +NG Sbjct: 343 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1072
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A267FZR2 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014479g2 PE=4 SV=1) HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0 Identity = 325/820 (39.63%), Postives = 445/820 (54.27%), Query Frame = 2 Query: 851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256 FEFQ L L S+ K+ P+C C E G ++ C QFH CL + KC DC + CF+C K DK+ M++C + CG+ YH C + + ++ S L CP H C AC +D P + S VRC+ CP+++H GD+C+PAGS E+++ I+CP+HL + +K+ NV WCF+C GG L+CCERCPAS H C + E+P F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP + + +H G F V FFGT++YYW++K F FEDGD G+++K G+++L + +++ +++A +A L E+ + KP Y+ I+TN P GN R+ K ADL+E+ +C+C S +PCG S+CMNR L YECHP +C + C NQRF++REYP Q VF T+ RGW L+ ++ I KG FVNEYVG+LIDE EA +RL AH+ V+NFYM+ LD RIIDAGP N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL IKAGEELTFNYNF LG +KL C+CGA NCSGFLG P++++ + S + K++ + T K + + CYRC I C + CP+VYHL C+ LS P W CPWH CD+CGR + CSEC SYC H +R+ + VC H+DL +++ + +NG Sbjct: 335 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1064
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A1I8H0A0 (Histone-lysine N-methyltransferase OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 580.096 bits (1494), Expect = 0.000e+0 Identity = 325/833 (39.02%), Postives = 445/833 (53.42%), Query Frame = 2 Query: 851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPD-------------GGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256 FEFQ L L S+ K+ P+C C E G ++ C QFH CL + KC DC + CF+C K DK+ M++C + CG+ YH C + + ++ S L CP H C AC +D P + S VRC+ CP+++H GD+C+PAGS E+++ I+CP+HL + +K+ NV WCF+C GG L+CCERCPAS H C + E+P F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP + + +H G F V FFGT++YYW++K F FEDGD G+++K G+++L + +++ +++A +A L E+ + KP Y+ I+TN P GN R+ K ADL+E+ +C+C S +PCG S+CMNR L YECHP +C + C NQRF++REYP Q VF T+ RGW L+ ++ I KG FVNEYVG+LIDE EA +RL AH+ V+NFYM+ LD RIIDAGP N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL IKAGEELTFNYNF LG +KL C+CGA NCSGFLG P++++ + S + K++ + T K + + CYRC I C + CP+VYHL C+ LS P W CPWH CD+CGR + CSEC SYC H +R+ + VC H+DL +++ + +NG Sbjct: 343 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQIPGFIFNLLLFTQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1085
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A2T7PCE1 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_10357 PE=4 SV=1) HSP 1 Score: 562.762 bits (1449), Expect = 4.914e-173 Identity = 319/805 (39.63%), Postives = 440/805 (54.66%), Query Frame = 2 Query: 848 NFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSG-SLTCPSHICHACYIDD---PEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV-VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVL-RTSKW--ESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLF 3220 ++ + KL + KK +C +C E L+ C G C FH CL+L KEP +C +C + CF C+K + E+ +CS S CG++YH C+ ++L G CP H+C C D+ P+AVK +RC+ CP+++H GD+CI AGS+ + +I+C H KPLK S++H NV+WCF C GG L+CCE CPA+ H CA +D +P + C DC G+ P YGDI W+KIG+YRWWPG+I HP N P + + +H G+F V+FFG++D+YW ++ F F++GD + K I A L ++ Y K +K A +A L + +K E + +N KP+ Y+ +K NVP+GNV+I+K ADL+EIP+CECRP + +PCG +EC+NR LMYECHP VC E+C NQRF +R+YP + T++RGW L+TL IKKG FV EYVG+L+DE E RR+ +AHE N++NFYM+ LD RIIDAGP N SRFMNHSC PN+ TQKW+VNGD R+GLF L I AG ELTFNYN LG +K C CG+ CSGFLG PKTA+ +K K + KK + EC+RCG+ + C +CP+VYHLQC++L+ P WLCPWH CD CG+++ CSEC S+C H + ++ + N+++VC+ H DL Sbjct: 572 DYVLEIFKLNSAGPPKKENICTVC-----EQAGELI-ECHGPCQSYFHTSCLKL------EKEPEAD----FRCSECCAGIHSCFACKK-----QDKEVRRCSVSQCGKFYHEECV-----KKLPQARMEGKGFICPLHVCATCAADNIRNPKAVK--GRLLRCVRCPTAYHVGDFCIAAGSKHLAGYHIVCSGHF----------------------------------------------KPLK---SQAHHVRINVSWCFSCSKGGSLVCCETCPAAFHIECAHLDSMPEDAWYCSDCAHGKRPLYGDIIWIKIGNYRWWPGEICHPRNVPVNIQEKAHQVGEFPVRFFGSHDFYWTHQGRVFLFQEGDRGS---KDISACRGLFKM---------------YCKGVKEATEAFKLWKAAKMNKEQLEQERNDRKPAPYKFVKANVPVGNVQIHK-ADLSEIPRCECRPDQE--NPCGSDTECLNRMLMYECHPQVCPAKESCHNQRFQKRQYPDLLPYRTESRGWGLKTLMDIKKGQFVIEYVGDLVDEDECKRRIAQAHEENITNFYMLTLDKNRIIDAGPKGNYSRFMNHSCEPNLETQKWTVNGDIRVGLFTLKDIPAGSELTFNYNLECLGNEKTKCSCGSDICSGFLGVRPKTAA----------------------AAHMEKRKREKDARKKKKKKKLDVKKEHEDECFRCGEGGELVMCDKPNCPKVYHLQCLNLAKPPHGKWLCPWHHCDVCGKLANKLCSECPNSFCQQH-ADGVISNINDSLVCAEHTDLI 1255
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3]) HSP 1 Score: 519.62 bits (1337), Expect = 1.493e-156 Identity = 297/761 (39.03%), Postives = 403/761 (52.96%), Query Frame = 2 Query: 962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL-VLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLV---DQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 C G C FH C+ L S+ P + + C +C + CF+C+ GE+ + +C CG++YH+ C+ Y NR C H+C ACYI +P + RC+ CP ++H D+C+ AGS + +N I+CP H + P K K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P+Y DI W+K+G YRWWP ++ P N PE +L+ H G+F V FFG+ DY W + FP+ +GD S+++++ + T D Y+K+L AA+ L+ K L + KN KP Y+ IK N PIG V+I ADL+EIP+C C+ +D+ PCG SEC+NR LMYEC+P VC GE C+NQ F +REY E+F T +RGW LR++ IKKGAFV+EYVGE+IDE E R+K A + ++SNFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLFAL I AG ELTFNYN LG K CKCGA NCSGFLG PK P DK L+ V + Q +++ + EC+ CG + I C CP+VYH C++L+ P W CPWH C++CGR + FC C SYC HR L S + + CS H+ Sbjct: 1221 CEGHCCGAFHLQCIGL------SEMPRGRFV----CKECKSGLHTCFVCKLSGED-----VRRCMVPVCGKFYHAECILK--YAPTAPQNRG--FRCSLHVCLACYITNPNNPSISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSILCPNHFT----------------------------------------------PRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQDSWYCNDCRAGKKPQYKDILWVKVGRYRWWPAEVTLPKNVPENILRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGD-----------ASNIEKMGKGT--------DAVYKKALNEAAERFRELQAEKEMRQLQEDRKNDKKPPPYKHIKVNRPIGKVQILT-ADLSEIPRCNCKATDET--PCGMDSECINRMLMYECNPQVCAAGERCQNQCFTKREYSPVEIFRTLSRGWGLRSVSEIKKGAFVSEYVGEMIDEEECRARIKHAQDNDISNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALEDIGAGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPPS---EDKGRKLK-----------------------KRVSGKRKSQSEVIKEREDECFYCGDSGQIISCKKPGCPKVYHADCLNLNKRPAGRWECPWHQCNECGREAASFCEMCPNSYCKQHRDGMLFISKLDGKLSCSEHD 1868
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2]) HSP 1 Score: 482.641 bits (1241), Expect = 1.105e-155 Identity = 269/662 (40.63%), Postives = 358/662 (54.08%), Query Frame = 2 Query: 1319 VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN------KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHEDLFLSHGSPTESQNGSINATLSI 3280 RC+ CP ++H D+CIPAGS + +N I+CP H P K ++ H NV+WCF+C +GG L+CCE CPA+ H+ C ID + C+DC++G+ P Y ++ W+K+G YRWWP ++ +P N PE +L+ H G+F V FFG+NDY W + FP+ +GD ANS ++ G G +D Y+K+L+ AAK ++ E + L+ KP Y+ IK N PIG V+I ADL+EIP+C CR +D+ PCG SEC+NR L+YEC+P VC GE C+NQRF++REY + E+F T +RGW LR IKKG FVNEYVGE+IDE E R+++A E ++ NFYM+ LD RIIDAGP N +RFMNHSC PN TQKW+VNGDTR+GLFAL I G ELTFNYN LG K CKCGA NCSGFLG PK P + K +K+ Q K + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ S FC C +SYC+ HR L S + + CS H+ P E + + T+S+ Sbjct: 16 TRCVRCPIAYHATDYCIPAGSVILANNLILCPNHFI----------------------------------------------PRKGCRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKNIPENILRMRHDVGEFPVLFFGSNDYLWTYQARVFPYMEGD----------ANS------KEKMGKG---VDSVYKKALEEAAKRFQELQAEKE-LRQLQEDRRNDKKPPPYKHIKANRPIGKVQIIT-ADLSEIPRCNCRATDE--SPCGMDSECINRMLLYECNPQVCPAGEKCQNQRFLKREYSEVEIFRTLSRGWGLRGCHDIKKGDFVNEYVGEVIDEEECRARIRQAQENDIGNFYMLTLDKDRIIDAGPKGNEARFMNHSCQPNCETQKWTVNGDTRVGLFALVDISTGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPSDDKGRKKRKGYMKRK------------------------QQQEVTKEREDECFSCGDGGQMVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQESASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHDPCGPDPLEPGEIREYPGSETVSL 584
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 505.753 bits (1301), Expect = 1.597e-155 Identity = 299/809 (36.96%), Postives = 400/809 (49.44%), Query Frame = 2 Query: 884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLP 3301 ++ KK +C +C +++ +LV C G C +H CL L PT KV+ C C V CF C++ + E+ +CS +CG+YYH CL L ++ G CP H C +C+ + K +RCL CP ++H GD C+ AGS + I+C H FN P K SH NV+WCF+C GG+L+CCE CPA+ H C I + C+DC+SG+ P+Y DI W+K+G+YRWWP +I HP N P + H G+F V FFG+ DY+W ++ FP+ +GD + + NG K+ + + K + + E+ N K KP Y+ IKTN P G V+I AD++EIP+C C+P+D+ PC SEC+NR L+YECHP VC GE C NQ F +R YP+ + T +GW L TL IKKG FVNEYVGELIDE E R++ A E ++++FYM+ ++ RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFA+ I G ELTFNYN LG +K C+CGA NCSGFLGD PK A S K+ S KK + EC+RCG + C + C + YHL C+ + P W CPWH CD CG+ S+ FC C S+C H L + C H+D L + + LS T SLP Sbjct: 678 ASVKKESVCQVC----EKTSEDLV-TCEGHCFATYHLQCLGL-------DHPTDKVL----CTACRTGVHACFTCKQ-----SEGEVKRCSVLHCGKYYHEACL---RLSALTVFDNRG-FRCPLHTCLSCHYSNRGTAKATKGKMIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNH----------------------------------FN------------PKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNYRWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRGSRHQR-----------------NGIGKVFKTALLEAETRFKQIKMEREAKEAHENNK-KPPPYKYIKTNKPCGRVQIYT-ADISEIPKCNCKPTDE--RPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLGDRPKIAPTSESKSKPQKKKPRKRRARSEG------------------------KKQSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKPSDAFCQHCPNSFCKAHEEGALRPHPVTSRLCCQEHDDTDLQASAEAAKE-------LSSTSQASLP 1363
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 506.138 bits (1302), Expect = 5.107e-155 Identity = 298/809 (36.84%), Postives = 400/809 (49.44%), Query Frame = 2 Query: 884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLP 3301 ++ KK +C +C +++ +LV C G C +H CL L PT KV+ C C V CF C++ + E+ +CS +CG+YYH CL L ++ G CP H C +C+ + K +RCL CP ++H GD C+ AGS + I+C H FN P K SH NV+WCF+C GG+L+CCE CPA+ H C I + C+DC+SG+ P+Y DI W+K+G+YRWWP +I HP N P + H G+F V FFG+ DY+W ++ FP+ +GD + + NG K+ + + K + + E+ N K KP Y+ IKTN P G V+I AD++EIP+C C+P+D+ PC SEC+NR L+YECHP VC GE C NQ F +R YP+ + T +GW L TL IKKG FVNEYVGELIDE E R++ A E ++++FYM+ ++ RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFA+ I G ELTFNYN LG +K C+CGA NCSGFLGD PK A + S +K KK + EC+RCG + C + C + YHL C+ + P W CPWH CD CG+ S+ FC C S+C H L + C H+D L + + LS T SLP Sbjct: 725 ASVKKESVCQVC----EKTSEDLV-TCEGHCFATYHLQCLGL-------DHPTDKVL----CTACRTGVHACFTCKQ-----SEGEVKRCSVLHCGKYYHEACL---RLSALTVFDNRG-FRCPLHTCLSCHYSNRGTAKATKGKMIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNH----------------------------------FN------------PKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNYRWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRGSRHQR-----------------NGIGKVFKTALLEAETRFKQIKMEREAKEAHENNK-KPPPYKYIKTNKPCGRVQIYT-ADISEIPKCNCKPTDE--RPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLGDRPKIAP------------------------TSESKSKPQKKKPRKRRARSEGKKQSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKPSDAFCQHCPNSFCKAHEEGALRPHPVTSRLCCQEHDDTDLQASAEAAKE-------LSSTSQASLP 1410
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 410.994 bits (1055), Expect = 7.036e-122 Identity = 215/536 (40.11%), Postives = 300/536 (55.97%), Query Frame = 2 Query: 1625 GGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN-----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASP-DSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 GG+L+CCE CPAS H C I+ V++C +C++G+ P Y I W+K+G+YRWWP +I +P P + H G F V FFG++DYYW+++ FP+ + D E G +++ ++K+L+ AAK ++ E+ L+ +P Y+ IK N P+G V+++ ADL+E+P+C CRP+D+ PCG S+C+NR L YECHP VC E C NQ F +R YP EV T RGW L+T + +KKG F+ EYVGELID E +R+ A++ +++NFYM+ L R+IDAGP N+SRFMNHSCSPN TQKW+VNGD RIGLF L I A ELTFNYN LG + C CGA NCSGFLG PK+A + E K+S L+ KK ++ + C+ CG+ + C + CP+ YHL C++L+ P W CPWH C C R + C C S+C H +L S+ + + C + D Sbjct: 759 GGRLLCCEACPASFHPSCLNIEMPEGVWLCSECRAGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDVGDFPVFFFGSHDYYWIHQGRVFPYVESDKNFAE--------------------GQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKANKPVGKVQVHV-ADLSEVPRCNCRPTDE--RPCGQDSQCLNRMLQYECHPQVCPAAERCLNQSFSKRVYPDTEVIKTSGRGWGLKTKQDLKKGDFIMEYVGELIDLEECRQRISHANKNHITNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDIRIGLFTLCDIAADTELTFNYNLDCLGNGRTSCHCGAENCSGFLGVRPKSAVVMEREEKVKNSKLKAKKRKLKLES-----------------------RQTHEYYCFCCGEGGELVMCDRKDCPKAYHLLCLNLTKPPYGRWECPWHQCSVCQRPASASCQFCPESFCREHEAGQLKVSAQDGLPCCSKHD 1248
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 494.582 bits (1272), Expect = 4.371e-153 Identity = 281/790 (35.57%), Postives = 399/790 (50.51%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCP-----------DGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLR----TSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214 K++ LC C +++G + +C G C FH +CL + P KV+ C +C+ + CF C+ G E+ +C+ S+CGR+YH C+ CP H+C +C++ P + + + RC+ CP ++H D C+ AGS+ ++ I+C H + C R + + P D F L +S + + P GG L+CCE CPA+ H C ++ + C +C++G+ P+Y DI W+K+G+YRWWP +I P N P+ + H GQF VQFFG++DYYW + FP+ +GD + + K N + R L+ AA+ L+ T + + + KP Y+ IK+N P+G V++ AD++EIP+C C+P+D+ PCG SEC+NR L YECHP +C G+ C+NQ F +R YP ++ T RGW L TL I+KG FVNEYVGELIDE E +R+K AHE N+SNFYM+ ++ RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFA I G ELTFNYN LG +K CKCGA NCSGFLG PKTA+ + + + + + + ECYRCG + C + CP+ YHL C++L+ P W CPWH CD CGR S C C S+C H+ L + + + +C D Sbjct: 564 KRDALCLAC----EKTGGGSLVSCEGQCCGTFHVECLGV------QTAPGDKVM----CNECSTGLHVCFACKCAGA-----EVRRCAVSSCGRFYHEECVQRSSAAVF----EGRRFRCPLHVCLSCHLAYPASSRASRGRMQRCVRCPVAYHTSDSCLAAGSKVLSPYSIVCSGHFTPNKRDSTWHVNVNWCFLCSRGVIGA------PLPDAGLALFEQSSHYLLSEYKRSSELGKLPMIPVVPAAAAKACGKGGCLLCCESCPAAFHPECLGMEPPEGTWCCAECRAGKKPQYHDIVWVKLGNYRWWPAEICQPRNIPQNIQNLKHTVGQFPVQFFGSHDYYWTTQGRVFPYMEGDKGSTDYKTNCLNKTFK------------------RALLEAAARYQALKAQRETREAQETERSERKPPTYKHIKSNKPVGRVQVYT-ADVSEIPRCNCKPTDE--SPCGLDSECLNRMLQYECHPSICPAGDRCQNQAFTKRAYPPSQIVKTAGRGWGLLTLVSIRKGEFVNEYVGELIDEEECRKRIKYAHEKNLSNFYMLTIEKDRIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFATSDIATGTELTFNYNLDCLGNEKTICKCGAPNCSGFLGVRPKTAAAAATEEKAKKAKRKARGRRPRTETARAEH---------------------EDECYRCGDGGELVMCDKKACPKAYHLSCLNLTKPPFGKWECPWHHCDVCGRPSVRSCELCPNSFCKEHQAGLLTRLTRDGRICCEEHD 1282
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003690.1 (pep scaffold:Pmarinus_7.0:GL484755:705:3732:1 gene:ENSPMAG00000003373.1 transcript:ENSPMAT00000003690.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 155.992 bits (393), Expect = 8.373e-43 Identity = 92/230 (40.00%), Postives = 116/230 (50.43%), Query Frame = 2 Query: 2543 RIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLW------LCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVC-SNHE 3211 RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFA+ I G ELTFNYN LG +K C CGA NCSGFLG PK S DK + +K K+ D ECYRC + C H++C + +HL C++L +P+ W L C G+ + FC C +S+C H L +SS+ + C + HE Sbjct: 3 RIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFAVSDIPCGTELTFNYNLDCLGNEKTVCMCGAPNCSGFLGVRPKRVRAQSAVVDKKPKRKYRKRKVRA-------------------------DKVHDSECYRCKDGGELVMCDHRNCTKTFHLACLNLGTLPEGKWAPRTLPLPHATRCRRSGKTAVAFCQICPSSFCKQHSLGALRRSSDGHHRCFAEHE 207
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005461.1 (pep scaffold:Pmarinus_7.0:GL477205:1717:42601:-1 gene:ENSPMAG00000004962.1 transcript:ENSPMAT00000005461.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 132.88 bits (333), Expect = 2.052e-31 Identity = 82/209 (39.23%), Postives = 109/209 (52.15%), Query Frame = 2 Query: 2177 KPADLTEIPQCEC-RPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQ-EVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAE----ANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKW--SVNGDTRIGLFALHTIKAGEELTFNYNFFSL-GQKKLPCKCGASNCSGFLG 2776 KP E C C RP + + C T C+NR + EC C GE C N+RF R+E E F T +RGW +RT + + EY+GE++ EA A R A + Y ++LD +ID+ N +RF+NHSC PN QKW SVNG RIGLFAL I ELT++YNF + + + PC CG+ NC +G Sbjct: 1107 KPLSGCEPVSCSCKRPEETEDSAC--TEGCLNRLVYAECVQSSCPCGELCTNRRFQRQERSAGLERFRTTDRGWGVRTTHHFQANDLIIEYLGEVLSEANFRAFAPRSRMLAQRGEQAGMYCVQLDSGVVIDSYRMGNEARFINHSCQPNCEMQKWCVSVNGIYRIGLFALKDIPISTELTYDYNFHTFTAESQRPCLCGSPNCRNVIG 1313
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: SUV39H2 (suppressor of variegation 3-9 homolog 2 [Source:HGNC Symbol;Acc:HGNC:17287]) HSP 1 Score: 105.916 bits (263), Expect = 2.891e-24 Identity = 72/196 (36.73%), Postives = 98/196 (50.00%), Query Frame = 2 Query: 2279 MYECHPLVCRNGENCRNQRFMRREYPKQE-VFSTDN-RGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELD---GQRIIDAGPAANISRFMNHSCSPNVYTQKWSVN----GDTRIGLFALHTIKAGEELTFNYNFFSLGQK----------------------KLPCKCGASNCSGFL 2773 +YEC+ L C+ G C+N R +++ P +F TDN RGW ++T++ IKK +FV EYVGELI EA RR + Y+ +LD +DA NIS F+NHSC PN+ +N RI FA+ + AGEELTF+YN + ++ CKCGAS C FL Sbjct: 229 IYECNSL-CQCGPECKN-RVVQKGIPFPLCIFRTDNGRGWGVKTMQKIKKNSFVMEYVGELIPSEEAERRGVIYDRAGTT--YLFDLDFCKDDYTVDATFYGNISHFVNHSCEPNLQVYSTFINNHDFSQPRIAFFAMDDLAAGEELTFDYNIKDSSSQNESCNKDTVLHTTVTTSPKQRARITCKCGASTCRKFL 420
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: setd1a (SET domain containing 1A, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-080521-4]) HSP 1 Score: 103.605 bits (257), Expect = 2.097e-22 Identity = 53/149 (35.57%), Postives = 85/149 (57.05%), Query Frame = 2 Query: 2333 RFMRREYPKQEVFSTDNR--GWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFL 2773 +F + ++ K+++ T +R W L LEPI V EYVG+ I + A+ R K+ + + Y+ +D IIDA N++RF+NHSC+PN Y + +V RI +++ I EE+T++Y F + + K+PC CGA +C G L Sbjct: 1706 KFNQLKFRKKKLRFTKSRIHEWGLFALEPIAAEEMVIEYVGQGIRQLVADMREKRYEVEGIGSSYLFRVDHDTIIDATKVGNLARFINHSCNPNCYAKVITVESQKRIVIYSKQAINVNEEITYDYK-FPIEENKIPCLCGAEHCRGTL 1853
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: RPS18B (Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004488]) HSP 1 Score: 191.43 bits (485), Expect = 9.127e-57 Identity = 87/137 (63.50%), Postives = 114/137 (83.21%), Query Frame = 1 Query: 3472 MSLIMPQK--FNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSL++ ++ F HILR++NTN+DG IVYALT I+GVGRR++++VCKKA+VD++KRAGE+T +ELE+I +M NPT YKIP WFLNRQ DI DG + +AN +++KLR+DLERLKKI+ HRG+RH WGLRVRGQH Sbjct: 1 MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQH 137
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: RPS18A (Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress [Source:SGD;Acc:S000002858]) HSP 1 Score: 191.43 bits (485), Expect = 9.127e-57 Identity = 87/137 (63.50%), Postives = 114/137 (83.21%), Query Frame = 1 Query: 3472 MSLIMPQK--FNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSL++ ++ F HILR++NTN+DG IVYALT I+GVGRR++++VCKKA+VD++KRAGE+T +ELE+I +M NPT YKIP WFLNRQ DI DG + +AN +++KLR+DLERLKKI+ HRG+RH WGLRVRGQH Sbjct: 1 MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQH 137
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: SET2 (Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000003704]) HSP 1 Score: 152.14 bits (383), Expect = 3.800e-38 Identity = 83/230 (36.09%), Postives = 121/230 (52.61%), Query Frame = 2 Query: 2138 IKTNVPIGNVRINKPADLTEIPQCECRP--SDKCNDPCGPTSECMNRELMYECHPLVCRN-GENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSD 2818 I N IG + N + +C+C SD N C S+C+NR + EC +C + G +C+NQRF +++Y +F T ++G+ +R + I+ F+ EY GE+I+E E RL + + +FY M L IDA +++RF NHSCSPN Y KW V R+G+FA I GEE+TF+YN G + C C NC GFLG +T + P + Sbjct: 51 IYANKRIGTFKNN------DFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQN 274
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: SET1 (Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain [Source:SGD;Acc:S000001161]) HSP 1 Score: 100.523 bits (249), Expect = 9.884e-22 Identity = 51/130 (39.23%), Postives = 71/130 (54.62%), Query Frame = 2 Query: 2390 WALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSL--GQKKLPCKCGASNCSGFL 2773 W L L+ I + EYVGE I + A R K+ + + + Y+ +D +IDA I+RF+NH C PN + V G RI ++AL I A EELT++Y F +++LPC CGA NC GFL Sbjct: 950 WGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFL 1079
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO43156 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZJ4]) HSP 1 Score: 420.239 bits (1079), Expect = 1.602e-131 Identity = 258/758 (34.04%), Postives = 369/758 (48.68%), Query Frame = 2 Query: 968 GGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV-VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPD-SEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFL 3223 G C +HPDC+ L S P K KC +C V CF+C++ G+ + CS C ++YH CL + ++ + CP H C C I + V + +C+ CP+++H G C+ AG I + + V K +KSK+H NV WCF+C GG LICCE CPA+ H C + + IP F C DC G+ YGDI W+K+G YRWWP I +P + P + H G+F V F G++D+YW++K F ++DGD T N L +V + K D +++K+ + A+ + R K KP QY+ IKTN RI D +E+P CEC P + CG + C+N L +EC C G+ C+NQRF +R+Y E F +RGW LR+ + IKKG FV EYVGELID+A R+KK + +N+YM+ +D IIDAGP N+SRFMNHSC PN TQKW+VNG+ R+GLF +++ EELTF+Y G +K C CG+ NCSGFLG PKT + +E K++ L+ +K + K++ + +C+ CG I C C + YH+ C++L P+ W CPWH CD+CG+ + CSEC S+C H ++ + +C++H D L Sbjct: 4 GDCNSAYHPDCIGL------STAPKGK----FKCDECTSGVHSCFVCRQTGD------VKACSQPLCSKFYHKECLQSYKCSKI----DGDRIYCPLHFCSTC-ISNKTPVNR-GRLTKCIRCPTAYHAG--CLVAGCMPITSHLM-------------------------------------------------VCAKHFLPNKSKAHHTHVNVNWCFVCSIGGTLICCESCPAAFHPECISYEGIPEGRFYCKDCVEGKSLLYGDIVWVKLGMYRWWPAMICNPRDVPTNIQSMRHQPGEFPVMFLGSHDFYWIHKGRVFSYQDGDKGTESGN----NKYLAKVFKKALVEAKEKYD-EWKKAREDKAEQDLQRFCK---------KPPQYKHIKTNKCTTAQRI--ILDPSEMPVCECTP----DQACGQDANCLNLMLQFECVASRCPAGDKCQNQRFQKRQYVDCEPFRAHSRGWGLRSKQAIKKGTFVIEYVGELIDDATCRERVKKGDDD--TNYYMLTIDKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQEELTFDYCLDCHGNEKKKCHCGSQNCSGFLGVRPKTQNAQMNEDKAKNAALKRRKRKPKKPAV----------------------KQVHEDDCFICGDGGQLIMCDRSGCLKCYHVDCLNLDKKPQGRWQCPWHFCDNCGKRATVLCSECPNSFCRSHAQGQINSTDKNTFLCTDHVDEVL 644
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO36934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH82]) HSP 1 Score: 218.394 bits (555), Expect = 1.053e-65 Identity = 95/135 (70.37%), Postives = 123/135 (91.11%), Query Frame = 1 Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSL++P+KF HILRV+NTNIDG++ I++A+T+I+GVGRR+A++VCKKA++D+NKRAGE+T+DE+E++ T+M NP YKIP WFLNRQ+D KDG QI+ANGLDNK+REDLERLKKI+ HRGLRH+WGLRVRGQH Sbjct: 1 MSLVIPEKFQHILRVLNTNIDGKQKIMFAMTSIKGVGRRYANIVCKKADIDMNKRAGELTEDEVERVVTIMQNPRQYKIPDWFLNRQKDHKDGKYSQILANGLDNKMREDLERLKKIRAHRGLRHYWGLRVRGQH 135
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO43763 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXE9]) HSP 1 Score: 158.688 bits (400), Expect = 2.022e-42 Identity = 87/208 (41.83%), Postives = 115/208 (55.29%), Query Frame = 2 Query: 2168 RINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT 2791 RINK CEC P D G +C+NR LM EC+ C G+ C N+RF K EVF T+ +GW ++TLE +++ FV EY GE+++ + R ++ ++Y M L IIDA +ISRF+NHSC PN TQKW+VNG RIG F L TIKAGEELTF+Y G+ C C + +C G +G T Sbjct: 19 RINKEVRKM---TCECYPEPDNPDFVGCGEDCLNRLLMIECNHR-CPCGDLCTNRRFQEGCKIKVEVFKTEKKGWGVKTLEDLEQNQFVIEYCGEVMNYRDFQSRAQRYDRQKRRHYYFMTLRADEIIDATLKGSISRFINHSCEPNCVTQKWTVNGLLRIGFFTLRTIKAGEELTFDYQLQRYGKIAQTCYCESPSCRGIIGGEKHT 222
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO44546 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVC2]) HSP 1 Score: 102.834 bits (255), Expect = 1.517e-24 Identity = 51/128 (39.84%), Postives = 72/128 (56.25%), Query Frame = 2 Query: 2390 WALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFL 2773 W L LEPI V EYVGE+I +A A+ R + E + + YM LD IIDA N +RF+NH C PN Y + +V +I +++ I+ EE+T++Y F + +K+PC CGA C G L Sbjct: 86 WGLFALEPIAADEMVIEYVGEVIRQAIADYRERCYEERGIGSSYMFRLDETTIIDATTMGNFARFINHCCDPNCYAKVIAVENMKKIVIYSKRDIQVDEEITYDYK-FPIEDEKIPCLCGAPQCRGTL 212
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO35277 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM02]) HSP 1 Score: 99.3673 bits (246), Expect = 1.007e-23 Identity = 66/197 (33.50%), Postives = 98/197 (49.75%), Query Frame = 2 Query: 2228 KCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQR---------IIDAGPAANISRFMNHSCSPNVYTQKWSVNG-DTR---IGLFALHTIKAGEELTFNYNF--FSLGQKKLPCKCGASNCSGFL 2773 +CN C +S+C NR V +NG R Q VF T +RGW LRTL+ + G F+ Y G++++E AN+ + + ++ +E R +IDA N R++NHSCSPN++ Q ++ D R + FA H I AG ELT++Y + S+ K+L C CG+S C G L Sbjct: 3 ECNSNCACSSQCFNR---------VVQNGIQLRLQ-----------VFKTKSRGWGLRTLDDVPCGTFICTYSGQIMNEEMANKEGRDYGDEYLAELDHIERPTTRSLFGEEHCYVIDAKAYGNCGRYLNHSCSPNLFVQNVFIDTHDLRFPWVAFFAQHNIPAGSELTWDYMYEVGSVQDKELRCYCGSSECRGRL 179
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:101172132]) HSP 1 Score: 507.294 bits (1305), Expect = 3.985e-157 Identity = 294/809 (36.34%), Postives = 410/809 (50.68%), Query Frame = 2 Query: 893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPD-SEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRL-VKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSIS 3310 +K +C +C +++G +LV C G C FH CL P+ K + L C C + CF C++ + E+ +C +CG++YH C+ L ++ G L CP H C +C+ K + RCL CP ++H GD C+ AGS I + I+C H + K G + VN V+WCF+C GG+L+CCE CPA+ H C I + C+DC++G+ PRY DI W+K+G+YRWWP +I HP N P + H G+F V FFG+ DY+W ++ FP+ +GD + + I + + + K+ R+ +++ + + KP Y+ IK N P G V++ AD++EIP+C C+P+D+ PCG SEC+NR L YECHP VC +GE C NQ F +R YP+ ++ T +GW L L IKKG FVNEY+GELIDE E R+K AHE N++NFYM+ +D RIIDAGP N SRFMNHSC PN TQKW+VNGDTR+GLFA+ I AG ELTFNYN LG +K C+CGA NCSGFLGD PK ++ +EP K + KK + KK + EC+RCG + C + C + YHL C++L+ P W CPWH CD CG+ SE FC C S+C H+ L + + C H++L E NG + S+ G + +S Sbjct: 573 RKEFVCQVC----EQAGEDLVP-CEGQCCGMFHLHCL----------GPSFKPEDKLLCQQCRAGIHSCFACKQ-----SEGEVRRCHVVHCGKFYHEACI---RLNPLTVFDNKG-LRCPLHACLSCHYGSRTKHKSTKGRLMRCLRCPVAYHVGDLCVAAGSEMITNTAIVCTNHFNA---------------KKGYSHHSHVN------------------------------VSWCFVCSKGGQLLCCESCPAAFHPDCLNIAMPDGSWYCNDCRAGKKPRYRDIIWVKLGTYRWWPAEIQHPRNIPTNIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGSKHQRTGIGRVFKNALLEAEARFKEMKMKREAKEAQESS------------------RKPPPYKFIKVNRPYGRVQVYT-ADVSEIPKCNCKPTDE--RPCGFESECLNRMLQYECHPQVCPSGERCCNQDFTKRLYPETKIIKTPGKGWGLVALRDIKKGKFVNEYIGELIDEEECRARIKYAHENNITNFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCHIPAGTELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNSNGHAAEPKGKRPKRKYKKRRSEG-------------------------KKKSEDECFRCGDGGQLVLCDKKTCTKAYHLSCLNLTKRPFGRWDCPWHHCDVCGKNSEAFCQLCPNSFCKAHQEGGLWPRPPGGELCCLEHDEL--------EGANGPAHDPGSVGGAAAPAPLS 1258
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 518.85 bits (1335), Expect = 5.515e-156 Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2 Query: 896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 K +C +C +++G L+ C G C FH C+ L + P K + C +C V CF+C+K GE+ + +C CG++YH C+ N + NR C H+C C+I +P + VRC+ CP ++H D C+ AGS ++ N I+CP H + P + K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P Y DI W+K+G YRWWP ++ HP PE + + H G+F V FFG+NDY W + FP+ D D ANS ++ G G +D Y+K+L+ AA + R + E L + KN KP Y+ IK N PIG V+I ADL+E+P+C C+ +D+ PCG SEC+NR L+YEC+P VC GE C NQ F +R+Y + E+F T +RGW LR + IKKG FV+EYVGE+IDE E R++ A E ++ NFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLFAL +KAG ELTFNYN LG K CKCGA NCSGFLG PK P DK ++ + + K + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +SYC HR L S + + CS H+ Sbjct: 1281 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDE--SPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 1944
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 518.85 bits (1335), Expect = 5.482e-155 Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2 Query: 896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 K +C +C +++G L+ C G C FH C+ L + P K + C +C V CF+C+K GE+ + +C CG++YH C+ N + NR C H+C C+I +P + VRC+ CP ++H D C+ AGS ++ N I+CP H + P + K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P Y DI W+K+G YRWWP ++ HP PE + + H G+F V FFG+NDY W + FP+ D D ANS ++ G G +D Y+K+L+ AA + R + E L + KN KP Y+ IK N PIG V+I ADL+E+P+C C+ +D+ PCG SEC+NR L+YEC+P VC GE C NQ F +R+Y + E+F T +RGW LR + IKKG FV+EYVGE+IDE E R++ A E ++ NFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLFAL +KAG ELTFNYN LG K CKCGA NCSGFLG PK P DK ++ + + K + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +SYC HR L S + + CS H+ Sbjct: 1687 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDES--PCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 2350
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 518.85 bits (1335), Expect = 5.482e-155 Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2 Query: 896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 K +C +C +++G L+ C G C FH C+ L + P K + C +C V CF+C+K GE+ + +C CG++YH C+ N + NR C H+C C+I +P + VRC+ CP ++H D C+ AGS ++ N I+CP H + P + K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P Y DI W+K+G YRWWP ++ HP PE + + H G+F V FFG+NDY W + FP+ D D ANS ++ G G +D Y+K+L+ AA + R + E L + KN KP Y+ IK N PIG V+I ADL+E+P+C C+ +D+ PCG SEC+NR L+YEC+P VC GE C NQ F +R+Y + E+F T +RGW LR + IKKG FV+EYVGE+IDE E R++ A E ++ NFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLFAL +KAG ELTFNYN LG K CKCGA NCSGFLG PK P DK ++ + + K + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +SYC HR L S + + CS H+ Sbjct: 1687 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDES--PCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 2350
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 518.079 bits (1333), Expect = 6.956e-155 Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2 Query: 896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211 K +C +C +++G L+ C G C FH C+ L + P K + C +C V CF+C+K GE+ + +C CG++YH C+ N + NR C H+C C+I +P + VRC+ CP ++H D C+ AGS ++ N I+CP H + P + K+ H NV+WCF+C +GG L+CCE CPA+ H+ C I+ + C+DC++G+ P Y DI W+K+G YRWWP ++ HP PE + + H G+F V FFG+NDY W + FP+ D D ANS ++ G G +D Y+K+L+ AA + R + E L + KN KP Y+ IK N PIG V+I ADL+E+P+C C+ +D+ PCG SEC+NR L+YEC+P VC GE C NQ F +R+Y + E+F T +RGW LR + IKKG FV+EYVGE+IDE E R++ A E ++ NFYM+ LD RIIDAGP N +RFMNH C PN TQKW+VNGDTR+GLFAL +KAG ELTFNYN LG K CKCGA NCSGFLG PK P DK ++ + + K + EC+ CG + C CP+VYH C++L+ P W CPWH CD CG+ + FC C +SYC HR L S + + CS H+ Sbjct: 1604 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDES--PCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 2267
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1) HSP 1 Score: 1700.26 bits (4402), Expect = 0.000e+0 Identity = 833/836 (99.64%), Postives = 835/836 (99.88%), Query Frame = 2 Query: 806 ALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 3313 ALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLG+NDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGS+EINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKI INKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI Sbjct: 296 ALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKILINKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 1131
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1) HSP 1 Score: 1669.83 bits (4323), Expect = 0.000e+0 Identity = 818/825 (99.15%), Postives = 821/825 (99.52%), Query Frame = 2 Query: 839 IVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 3313 + FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLG+NDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGS+EINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKI INKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI Sbjct: 292 VAETFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKILINKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 1116
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000015015.1 (SMESG000015015.1) HSP 1 Score: 492.271 bits (1266), Expect = 1.132e-155 Identity = 290/791 (36.66%), Postives = 409/791 (51.71%), Query Frame = 2 Query: 845 LNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHL-SMGGSAEITVTPFMDCIKNG---RVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES-----ILNLKNKPSQYRSIKTN-VPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQ---NNCEIFCSHQHCPRVYHLQCVSL--SNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYC---LLHRFN 3163 + + F L LP S N C CLE + + C FH CL L + + TK+ + +C++C+ + RC+ C K+ + + M+C C +++H+NCL G ++ + + G L CP HICH C + +P +C+ + C+MCP++FH GDWCIPAGS E+N IICP+HL + S I V PF+ +K+ R+ N+ LT ++P + KP NV WCF C +GG+L+CCE CPA+ H C + EIP F C DC S Y YG+I W+K G++ WWPGQI+H N P+ + H +GQF+VQFFG+ DY W + + F +E D+ + K N N L+R +K AA V R KW+S ++N K Y I+ N P+ R P E P C C D +D C S C N EC P +C G+ C+NQ F++R YPKQ F ++RGW L+ E IK FVNEY+GE+I E+ +R+ A+E N+S+FY MELD R+IDA +N+SRF+N+SC PN+ +KW VN + RIGLFAL I+ GEELTF YN + ++ CKC + NCSGFLG+ PK A SD S + ++F K + +C+RCG+ I CS C + YH C++L +N +S W+CP H CD C R S +F S T SYC + +FN Sbjct: 178 IKYAFDELTLPFVSVKLTNKNCRYCLETKN------IVQCNKCLFNNFHVKCLEFLQNSIE-----TKINDLDRCLECSLGIIRCYACYKIVDISNEQGFMRCIIKTCTKWFHTNCLETGPMLEMTKFPKPGQLVCPCHICHKCELVNPSPKYRCTKLIVCIMCPATFHTGDWCIPAGSVELNTGEIICPRHLVDLNFSMNIMVPPFVARVKSDLQERIYGNT----LTKISEPMTITPSTVTKPT--------NVNWCFKCGEGGELLCCETCPAAYHFKCTDLKEIPQKFYCPDCASFCYRSYGEIVWIKCGTHPWWPGQILHLENVPKNIAAKKHANGQFVVQFFGSRDYMWRDHGNVFLYEKEDECNSKTSKYRYN--------------NIFLER-----IKEAAIGYVTREEKWQSGSCDHVMNSK----IYNKIQVNKCPLELRRKVVP----ETPHCNCISFDPKSD-CSIGSGCFNVASKCECDPQICNLGDKCKNQNFVKRIYPKQYTFWANDRGWGLKADEFIKTKQFVNEYIGEIITMEESEKRILWANENNISDFYFMELDNGRLIDARQFSNLSRFINNSCDPNLVAEKWIVNREHRIGLFALRDIQKGEELTFQYNLQNKSSNRIVCKCFSVNCSGFLGEAPKMAKVSKLKSDTSK------------------KSKGDTTESESSCKSFLTDKNSNSQCFRCGEIIDMLSSIVCSVGPCMKTYHSVCLNLNMANYVQSSWICPHHYCDVCARPSHHFSSNTTESYCNKDFIKKFN 899
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000081033.1 (SMESG000081033.1) HSP 1 Score: 388.267 bits (996), Expect = 6.260e-117 Identity = 264/842 (31.35%), Postives = 392/842 (46.56%), Query Frame = 2 Query: 944 NNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPE-AVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKA-----------LVLRTSKWESI--------LNLK---NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLP-CKCGASNCSGFLGDPPKTASPD----SEPSDKDSILELXX---XXXXXXXXXXXXXXXXXXXXXTVDL------------------QNFFQKKLVDQE------------CYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMV---CSNHEDLFLSHGSPTESQNGSINATLS 3277 NN V CTG C + FH CL+ L +PT+K +C+DC + C +CQK+ DK D+++ C S+CGR YH +CL ++ I + + L+CPSH C +C +D A C V CL CP SFH D C+ AG+ E++ +++ICP+H +N VKLN+ K + WCF C G + C CPAS H C + ++C +C++ R PRYG++ ++K+ YRWWP +IIHP NAP +LK + DG + V F G+N+Y W+ KT + F T + I S G T++DRD+ L++A K + LR+ S+ +N+K K +++ IK N+ I PA L P+ + D C D C P +C N EC C C+NQ+F ++ VF T NRG+ L+T PI K F+ EY+GELI + E+ R+ A + N +FYM+ L G +IDAGP N+SR+MNHSC PN Y + W VNG + G+FAL I + +ELTF+Y + K+ C C ++NC+GFLG P + P+ S+ + ++S + L + + + +DL N ++K + + CYRC + C +CP+ YHL C+ L P W CPWH CD CG+ S+ FC C S+C H + N++ + + L H SP E+Q ++ S Sbjct: 155 NNAVLQCTGICKRYFHLHCLK----NLKENQPTSKP--NFQCLDCFSGIYHCILCQKV---DKIDDLLACENSDCGRLYHKSCLEMSNFIG-IEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHF-----------------ENKLVKLNA---------------------------HKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFN-----TAQFSSIFKESG-----------GTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANI------IVPPAKLP--PKVQASICD-CVDNC-PKQDCKNYLNKIECQITQC---PKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG--PIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLITEAPILDESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH-------AQETNIIIPTIKTRKSICLLHKSPPENQTSYLHDEAS 904
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039926.1 (SMESG000039926.1) HSP 1 Score: 280.796 bits (717), Expect = 1.688e-87 Identity = 135/135 (100.00%), Postives = 135/135 (100.00%), Query Frame = 1 Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH Sbjct: 1 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 135 The following BLAST results are available for this feature:
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 4
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002598 ID=SMED30002598|Name=Histone-lysine N-methyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=3973bpback to top protein sequence of SMED30002598-orf-1 >SMED30002598-orf-1 ID=SMED30002598-orf-1|Name=SMED30002598-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=155bp MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVback to top protein sequence of SMED30002598-orf-2 >SMED30002598-orf-2 ID=SMED30002598-orf-2|Name=SMED30002598-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=725bp MMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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