Histone-lysine N-methyltransferase

Overview
NameHistone-lysine N-methyltransferase
Smed IDSMED30002598
Length (bp)3973
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Histone-lysine N-methyltransferase (SMED30002598) t-SNE clustered cells

Violin plots show distribution of expression levels for Histone-lysine N-methyltransferase (SMED30002598) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Histone-lysine N-methyltransferase (SMED30002598) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Histone-lysine N-methyltransferase (SMED30002598) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30002598

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 21

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30002598h1SMcG0010730 SmedASXL_014954SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30002598h1SMcG0010730 Contig51307uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002598h1SMcG0010730 Contig51307newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
muscle cellSMED30002598h1SMcG0010730 dd_Smed_v4_9808_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30002598h1SMcG0010730 dd_Smed_v4_4755_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30002598h1SMcG0010730 dd_Smed_v4_4755_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30002598h1SMcG0010730 dd_Smed_v6_9808_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
body wall musculatureSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30002598h1SMcG0010730 dd_Smed_v6_99_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 2 cellSMED30002598h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30002598h1SMcG0010730 dd_Smed_v4_4755_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767])

HSP 1 Score: 509.605 bits (1311), Expect = 9.267e-157
Identity = 293/780 (37.56%), Postives = 408/780 (52.31%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTA-SPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK+ +C +C    + SG++L+  C G C + FH +CL L      +  P +K I    C++C      CF C+  G++ K+     CS   CG++YH  C+    +   I    S    CP H C AC ++           +RCL CP ++H GD CI AGS  ++   +IC  H                                                  + S S + NV +CF+C  GG+L+CCE CPAS H  C +I+     + C+DC++G+   Y  I W+K+G+YRWWP +I +P + P  +    H  G F V FFG++DYYW+++   FP+ +GD    E                    G T +++ ++K+L+ AAK      ++ ES   L+      KP  Y+ IK N  IG V+I + ADL+EIP+C C+P+D+  +PCG  SEC+NR L YECHP VC  G+ C+NQ F +R YP  E+  T+ RGW LRT   IKKG FVNEYVGELIDE E   R+K+AHE +V+NFYM+ +   RIIDAGP  N SRFMNHSC+PN  TQKW+VNGD R+GLFAL  I AG ELTFNYN   LG  +  C CGA NCSGFLG  PK+A +  +E   K++ L+ K+                              K++ +  C++CG     + C  + CP+ YHL C++L+  P   W CPWH CD+C   +  FC  C  S+C  H    LV S+ E  +C +  D
Sbjct:  699 KKDTVCQIC----ESSGDSLIP-CEGECCKHFHLECLGL------ASLPDSKFI----CMECKTGQHPCFSCKVSGKDVKR-----CSVGACGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSK------------------------------------------------RSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQI-QVADLSEIPRCNCKPADE--NPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEP-----------------------KQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1360          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767])

HSP 1 Score: 508.834 bits (1309), Expect = 5.253e-156
Identity = 296/787 (37.61%), Postives = 418/787 (53.11%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRV-------KLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTA-SPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK+ +C +C    + SG++L+  C G C + FH +CL L      +  P +K I    C++C      CF C+  G++ K+     CS   CG++YH  C+    +   I    S    CP H C AC ++           +RCL CP ++H GD CI AGS  ++   +IC  H     ++      F      G +         +S  +K     +  N+   +++ P+  S S S        C  GG+L+CCE CPAS H  C +I+     + C+DC++G+   Y  I W+K+G+YRWWP +I +P + P  +    H  G F V FFG++DYYW+++   FP+ +GD    E                    G T +++ ++K+L+ AAK      ++ ES   L+      KP  Y+ IK N  IG V+I + ADL+EIP+C C+P+D+  +PCG  SEC+NR L YECHP VC  G+ C+NQ F +R YP  E+  T+ RGW LRT   IKKG FVNEYVGELIDE E   R+K+AHE +V+NFYM+ +   RIIDAGP  N SRFMNHSC+PN  TQKW+VNGD R+GLFAL  I AG ELTFNYN   LG  +  C CGA NCSGFLG  PK+A +  +E   K++ L+ K+                              K++ +  C++CG     + C  + CP+ YHL C++L+  P   W CPWH CD+C   +  FC  C  S+C  H    LV S+ E  +C +  D
Sbjct:  699 KKDTVCQIC----ESSGDSLIP-CEGECCKHFHLECLGL------ASLPDSKFI----CMECKTGQHPCFSCKVSGKDVKR-----CSVGACGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIPSSSASKK-----KCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQI-QVADLSEIPRCNCKPADE--NPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEP-----------------------KQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234])

HSP 1 Score: 518.079 bits (1333), Expect = 1.686e-154
Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C   C   FH +CL L      ++ P  K I    C +C   +  CF+C++ GE+ K+     C    CG++YH  C+    Y   +  N+     C  HIC  C+  +P  V      + RC+ CP ++H  D+C+ AGS+ +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CC+ CPA+ H+ C  ID     + C+DC++G+ P Y +I W+K+G YRWWP +I HP   P  + K  H  G+F V FFG+NDY W ++   FP+ +GD  +                +D  G G   +D  Y+K+L+  AA+   L+  K    L  + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  G  C+NQ F +R+YP+ E+F T  RGW LRT   IKKG FVNEYVGELIDE E   R++ A E +++NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKWSVNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     +E   K    + +    +                     Q    K+  D EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +S+C  HR   L  S  +  + C+ H+
Sbjct: 1289 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 1937          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234])

HSP 1 Score: 518.079 bits (1333), Expect = 1.686e-154
Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C   C   FH +CL L      ++ P  K I    C +C   +  CF+C++ GE+ K+     C    CG++YH  C+    Y   +  N+     C  HIC  C+  +P  V      + RC+ CP ++H  D+C+ AGS+ +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CC+ CPA+ H+ C  ID     + C+DC++G+ P Y +I W+K+G YRWWP +I HP   P  + K  H  G+F V FFG+NDY W ++   FP+ +GD  +                +D  G G   +D  Y+K+L+  AA+   L+  K    L  + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  G  C+NQ F +R+YP+ E+F T  RGW LRT   IKKG FVNEYVGELIDE E   R++ A E +++NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKWSVNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     +E   K    + +    +                     Q    K+  D EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +S+C  HR   L  S  +  + C+ H+
Sbjct: 1289 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 1937          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234])

HSP 1 Score: 518.079 bits (1333), Expect = 2.758e-154
Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C   C   FH +CL L      ++ P  K I    C +C   +  CF+C++ GE+ K+     C    CG++YH  C+    Y   +  N+     C  HIC  C+  +P  V      + RC+ CP ++H  D+C+ AGS+ +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CC+ CPA+ H+ C  ID     + C+DC++G+ P Y +I W+K+G YRWWP +I HP   P  + K  H  G+F V FFG+NDY W ++   FP+ +GD  +                +D  G G   +D  Y+K+L+  AA+   L+  K    L  + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  G  C+NQ F +R+YP+ E+F T  RGW LRT   IKKG FVNEYVGELIDE E   R++ A E +++NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKWSVNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     +E   K    + +    +                     Q    K+  D EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +S+C  HR   L  S  +  + C+ H+
Sbjct: 1558 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2206          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: rps-18 (Ribosomal Protein, Small subunit [Source:UniProtKB/TrEMBL;Acc:O18240])

HSP 1 Score: 213.386 bits (542), Expect = 1.061e-63
Identity = 96/135 (71.11%), Postives = 117/135 (86.67%), Query Frame = 1
Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSLI+P+KF HI RVMNTNIDG R + YALTAI+GVGRRFA V C+KA+VDVNKRAGE+T+++ +KI T+M NP+ YKIP WFLNRQ+DIKDG   Q+++  +DNKLREDLER+KKI+ HRGLRH+WGLRVRGQH
Sbjct:    1 MSLIIPEKFQHIHRVMNTNIDGNRKVPYALTAIKGVGRRFAFVCCRKADVDVNKRAGELTEEDFDKIVTIMQNPSQYKIPNWFLNRQKDIKDGKTGQLLSTAVDNKLREDLERMKKIRLHRGLRHYWGLRVRGQH 135          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: met-1 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:A4LBC2])

HSP 1 Score: 134.806 bits (338), Expect = 2.296e-31
Identity = 84/213 (39.44%), Postives = 123/213 (57.75%), Query Frame = 2
Query: 2192 TEIPQCEC-RPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDN-RGWALRTLEPIKKGAFVNEYVGELIDEAE-ANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVN---GDT-RIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSE 2809
            TE   CEC R    C+D     + C+NR ++ EC P  C+    C+NQRF +++Y   E F T   +G  LR ++ IKKG F+ EY+GE+++  +   R+ K A +    + Y+ +  G   IDA    N SRF+NHSC PN   +KWSV    GD  R+G F+   IKAGEE+TF+Y F + G+    C CG+++CSG++G  P+  S D +
Sbjct:  622 TESLTCECHRTGGNCSD-----NTCVNRAMLTEC-PSSCQV--KCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYLCDT-GVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQFVNYGRDAQQCFCGSASCSGWIGQKPEEFSSDED 825          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: met-1 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:A4LBC2])

HSP 1 Score: 134.42 bits (337), Expect = 2.577e-31
Identity = 84/213 (39.44%), Postives = 123/213 (57.75%), Query Frame = 2
Query: 2192 TEIPQCEC-RPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDN-RGWALRTLEPIKKGAFVNEYVGELIDEAE-ANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVN---GDT-RIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSE 2809
            TE   CEC R    C+D     + C+NR ++ EC P  C+    C+NQRF +++Y   E F T   +G  LR ++ IKKG F+ EY+GE+++  +   R+ K A +    + Y+ +  G   IDA    N SRF+NHSC PN   +KWSV    GD  R+G F+   IKAGEE+TF+Y F + G+    C CG+++CSG++G  P+  S D +
Sbjct:  636 TESLTCECHRTGGNCSD-----NTCVNRAMLTEC-PSSCQV--KCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYLCDT-GVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQFVNYGRDAQQCFCGSASCSGWIGQKPEEFSSDED 839          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: set-12 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:Q21404])

HSP 1 Score: 119.783 bits (299), Expect = 1.685e-28
Identity = 73/194 (37.63%), Postives = 102/194 (52.58%), Query Frame = 2
Query: 2228 KCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNR-GWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGD--TRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASP 2800
            KC   C  T EC N     EC P  C    NC NQRF +R++   E F TDN  G  LR  E I  G  + EY GE I +AE N+R+K+  +  + + Y  E+     +D     N +RF+NHSC+PN   + W+V       +G+FA   IK GEE+TF+Y   +  +   PC+CG + C G++G P  +  P
Sbjct:   58 KCGTDC-TTEECSNFANHREC-PRGC---SNCENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKLILEYRGEAITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSCNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDYG--TSFRNDQPCQCGEAACRGWIGKPSTSEVP 244          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221])

HSP 1 Score: 103.219 bits (256), Expect = 4.882e-22
Identity = 46/129 (35.66%), Postives = 70/129 (54.26%), Query Frame = 2
Query: 2387 GWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFL 2773
            GW L  +E I     + EY+G+ I    A  R K      + + Y+  +D   +IDA    N +RF+NHSC PN Y +  ++ G+ RI +++   IK GEE+T++Y  F +   K+ C CGA  C G+L
Sbjct:  611 GWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYK-FPIEDDKIDCLCGAKTCRGYL 738          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0335014)

HSP 1 Score: 357.066 bits (915), Expect = 4.230e-102
Identity = 218/690 (31.59%), Postives = 333/690 (48.26%), Query Frame = 2
Query:  881 FSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCL---------------RLLFDYLTSKEPT-------------TKVINYLKCVDCN-RNVRRCFICQKL---------------GENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQ---CSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV----VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL-VLRTSKWESILNLKN----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSL-GQKKLPCKCGASNCSGFLG 2776
            F    + P+C  C +    +G++LV  C+  C    H DCL               + L    TSK P+               V   L C +CN      C IC ++                    +D+++ CS   CG+ +H++C    ++ Q  +   S    CP H+CH C  DDP    Q    S   +C+ CP+++H+   CIPAG++ +N   IICP+H                                                   ++K+ +H NV WC++C  GG+L+CCE CP ++H HC     IP+     +IC++C+SGR P YG+I W K  ++RWWP  I+ P   P  +LK +HG+  F+V+FFGT+D+ W+++   + + +GD   G   K                   ++L R+Y   ++ A++ L +++  + E  +  ++     P  Y  IKTN  +  +R ++  +L ++  C C P D+   PCGP + C+NR L  EC+P  C+ G  C N+ F +R+ P+ EV   + RG+ L   EPI  G FV EYVGE+I+ AE  RR+++       N+Y + ++   IIDAGP  N++RFMNHSC PN  TQKW+VN   R+G+FA+  I    ELTFNY +  L    K  C CGA  CSG +G
Sbjct:  767 FRGLSREPICKYCYQ----AGSDLV-RCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCC--KYWPQASSSKHSAR--CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH--------------------------------------------------NIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCR---NIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK-------------------SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQ--NLEDLSTCNCLPVDE--HPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIG 1371          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0085267)

HSP 1 Score: 357.066 bits (915), Expect = 4.433e-102
Identity = 218/690 (31.59%), Postives = 333/690 (48.26%), Query Frame = 2
Query:  881 FSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCL---------------RLLFDYLTSKEPT-------------TKVINYLKCVDCN-RNVRRCFICQKL---------------GENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQ---CSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV----VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL-VLRTSKWESILNLKN----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSL-GQKKLPCKCGASNCSGFLG 2776
            F    + P+C  C +    +G++LV  C+  C    H DCL               + L    TSK P+               V   L C +CN      C IC ++                    +D+++ CS   CG+ +H++C    ++ Q  +   S    CP H+CH C  DDP    Q    S   +C+ CP+++H+   CIPAG++ +N   IICP+H                                                   ++K+ +H NV WC++C  GG+L+CCE CP ++H HC     IP+     +IC++C+SGR P YG+I W K  ++RWWP  I+ P   P  +LK +HG+  F+V+FFGT+D+ W+++   + + +GD   G   K                   ++L R+Y   ++ A++ L +++  + E  +  ++     P  Y  IKTN  +  +R ++  +L ++  C C P D+   PCGP + C+NR L  EC+P  C+ G  C N+ F +R+ P+ EV   + RG+ L   EPI  G FV EYVGE+I+ AE  RR+++       N+Y + ++   IIDAGP  N++RFMNHSC PN  TQKW+VN   R+G+FA+  I    ELTFNY +  L    K  C CGA  CSG +G
Sbjct:  771 FRGLSREPICKYCYQ----AGSDLV-RCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCC--KYWPQASSSKHSAR--CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH--------------------------------------------------NIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCR---NIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK-------------------SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQ--NLEDLSTCNCLPVDE--HPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIG 1375          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: RpS18 (gene:FBgn0010411 transcript:FBtr0086274)

HSP 1 Score: 197.593 bits (501), Expect = 4.155e-58
Identity = 86/135 (63.70%), Postives = 117/135 (86.67%), Query Frame = 1
Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSL++P+KF HILR+MNTNIDG+R +  A+TAI+GVGRR++++V KKA+VD+ KRAGE T++E++K+ T+++NP  YK+P WFLNRQ+DI DG   Q+ ++ LD+KLR+DLERLKKI+ HRGLRH+WGLRVRGQH
Sbjct:    1 MSLVIPEKFQHILRIMNTNIDGKRKVGIAMTAIKGVGRRYSNIVLKKADVDLTKRAGECTEEEVDKVVTIISNPLQYKVPNWFLNRQKDIIDGKYWQLTSSNLDSKLRDDLERLKKIRSHRGLRHYWGLRVRGQH 135          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: RpS18 (gene:FBgn0010411 transcript:FBtr0086273)

HSP 1 Score: 197.593 bits (501), Expect = 4.155e-58
Identity = 86/135 (63.70%), Postives = 117/135 (86.67%), Query Frame = 1
Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSL++P+KF HILR+MNTNIDG+R +  A+TAI+GVGRR++++V KKA+VD+ KRAGE T++E++K+ T+++NP  YK+P WFLNRQ+DI DG   Q+ ++ LD+KLR+DLERLKKI+ HRGLRH+WGLRVRGQH
Sbjct:    1 MSLVIPEKFQHILRIMNTNIDGKRKVGIAMTAIKGVGRRYSNIVLKKADVDLTKRAGECTEEEVDKVVTIISNPLQYKVPNWFLNRQKDIIDGKYWQLTSSNLDSKLRDDLERLKKIRSHRGLRHYWGLRVRGQH 135          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0073779)

HSP 1 Score: 162.925 bits (411), Expect = 8.540e-40
Identity = 81/195 (41.54%), Postives = 113/195 (57.95%), Query Frame = 2
Query: 2243 CGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDS 2827
            CG  + C+NR LM EC PL C NG  C N+RF + +     VF T+ +G  +     I  G F+ EYVGE+ID  E  RR     +    ++Y M L G+ +IDA    NISR++NHSC PN  TQKW+VNG+ RIG F++  I+ GEE+TF+Y +   G+    C C A+NC G++G  P +   +    + DS
Sbjct: 1377 CG--AGCINRMLMIECGPL-CSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDS 1568          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2])

HSP 1 Score: 530.02 bits (1364), Expect = 1.448e-163
Identity = 302/787 (38.37%), Postives = 414/787 (52.60%), Query Frame = 2
Query:  884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN---------KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            S   K  +C +C ++ D      +  C G C   FHP C  L      ++ PT K +    C +C   V  CF C++LGE+     + +C    CG++YH  C     +   +  NR+    CP H C +C+I +P         + RC+ CP ++H  D+CIPAGS  + D+ I+CP H           TP   C  +  V                                   NV+WCF+C +GG L+CCE CPA+ H+ C  ID     + C+DC++G+ P Y ++ W+K+G YRWWP ++ +P + PE +L+  H  G+F V FFG+NDY W  +   FP+ +GD          ANS      ++  G G   +D  Y+K+L  AA    LR  + ++   L+          KP  Y+ IK N P G V I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  GE C+NQ F++R+Y + E F T +RGW LR +  IKKG F++EYVGE+IDE E   R+K A E N+ NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLF+L  I AG ELTFNYN   LG  K  CKCGASNCSGFLG  PK    ++ PSD       KK  +                      Q   +++  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +SYC+ HR   L  S  +  + CS H+
Sbjct:  716 STSVKENVCPMCEKQGD------LLLCEGQCCGAFHPQCTGL------NEPPTGKFL----CQECTSGVHSCFACKRLGED-----VRRCMVPGCGKFYHGECA--ASHAPTVPLNRA--FRCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHF----------TPRKGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGD----------ANS------KEKMGKG---VDSTYKKALDEAA----LRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIIS-ADLSEIPRCNCKATDE--NPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLGVRPK----NNPPSDDKGRKLKKKRKSQ---------------------QEVIKER--EDECFSCGDGGQIVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQEAASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHD 1379          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2])

HSP 1 Score: 530.406 bits (1365), Expect = 4.453e-161
Identity = 302/787 (38.37%), Postives = 414/787 (52.60%), Query Frame = 2
Query:  884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN---------KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            S   K  +C +C ++ D      +  C G C   FHP C  L      ++ PT K +    C +C   V  CF C++LGE     ++ +C    CG++YH  C     +   +  NR+    CP H C +C+I +P         + RC+ CP ++H  D+CIPAGS  + D+ I+CP H           TP   C  +  V                                   NV+WCF+C +GG L+CCE CPA+ H+ C  ID     + C+DC++G+ P Y ++ W+K+G YRWWP ++ +P + PE +L+  H  G+F V FFG+NDY W  +   FP+ +GD          ANS      ++  G G   +D  Y+K+L  AA    LR  + ++   L+          KP  Y+ IK N P G V I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  GE C+NQ F++R+Y + E F T +RGW LR +  IKKG F++EYVGE+IDE E   R+K A E N+ NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLF+L  I AG ELTFNYN   LG  K  CKCGASNCSGFLG  PK    ++ PSD       KK  +                      Q   +++  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +SYC+ HR   L  S  +  + CS H+
Sbjct: 1091 STSVKENVCPMCEKQGD------LLLCEGQCCGAFHPQCTGL------NEPPTGKFL----CQECTSGVHSCFACKRLGE-----DVRRCMVPGCGKFYHGECA--ASHAPTVPLNRA--FRCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHF----------TPRKGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGD----------ANS------KEKMGKG---VDSTYKKALDEAA----LRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIIS-ADLSEIPRCNCKATDE--NPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLGVRPK----NNPPSDDKGRKLKKKRKSQ---------------------QEVIKER--EDECFSCGDGGQIVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQEAASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHD 1754          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3])

HSP 1 Score: 513.072 bits (1320), Expect = 4.958e-154
Identity = 291/758 (38.39%), Postives = 398/758 (52.51%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C G C   FH  C+ L      ++ P  + I    C +C   V  CF+C+K  +     E+ +C    CG++YH +C+    Y   +  NR     C  H+C +CYI +P         + RC+ CP ++H  D+C+ AGS  + +N  +CP H +                                              P K  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P Y DI W+K+G YRWWP ++  P + PE + +  H  G+F V FFG+ DY W  +   FP+ +GD          AN+      ++  G G    D  Y+K+L  AA   + L+      +   + KN  KP  Y+ IK N  IG V I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECH  VC  GE C+NQ F +R+Y + E+F T +RGW LR++  IKKGAFVNEYVGE+IDE E   R+K A + ++ NFYM+ LD  RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFAL  I  G ELTFNYN   LG  K  CKCGA NCSGFLG       P ++P   D   +L++  +   K                  Q+   K+  D EC+ CG     + C    CP+VYH  C++LS  P   W CPWH C++CGR +  +C  C  SYC  HR   L  S  +  + CS H+
Sbjct: 1241 CEGQCCGAFHLQCIGL------TETPKGRFI----CQECKMGVHTCFVCKKPDK-----EVRRCMIPVCGKFYHMDCILK--YSPTVAQNRG--FRCSIHVCLSCYITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFT----------------------------------------------PRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGD----------ANN------KEKMGKG---ADAVYKKALNEAADRFRELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIIT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPNCSGFLG-----VRPKNQPPSDDKTRKLRRKVSGKRKS-----------------QSEVTKERED-ECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHREGMLFISKLDGKLSCSEHD 1888          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3])

HSP 1 Score: 513.072 bits (1320), Expect = 5.603e-154
Identity = 291/758 (38.39%), Postives = 398/758 (52.51%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C G C   FH  C+ L      ++ P  + I    C +C   V  CF+C+K  +     E+ +C    CG++YH +C+    Y   +  NR     C  H+C +CYI +P         + RC+ CP ++H  D+C+ AGS  + +N  +CP H +                                              P K  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P Y DI W+K+G YRWWP ++  P + PE + +  H  G+F V FFG+ DY W  +   FP+ +GD          AN+      ++  G G    D  Y+K+L  AA   + L+      +   + KN  KP  Y+ IK N  IG V I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECH  VC  GE C+NQ F +R+Y + E+F T +RGW LR++  IKKGAFVNEYVGE+IDE E   R+K A + ++ NFYM+ LD  RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFAL  I  G ELTFNYN   LG  K  CKCGA NCSGFLG       P ++P   D   +L++  +   K                  Q+   K+  D EC+ CG     + C    CP+VYH  C++LS  P   W CPWH C++CGR +  +C  C  SYC  HR   L  S  +  + CS H+
Sbjct: 1257 CEGQCCGAFHLQCIGL------TETPKGRFI----CQECKMGVHTCFVCKKPDK-----EVRRCMIPVCGKFYHMDCILK--YSPTVAQNRG--FRCSIHVCLSCYITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFT----------------------------------------------PRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGD----------ANN------KEKMGKG---ADAVYKKALNEAADRFRELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIIT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPNCSGFLG-----VRPKNQPPSDDKTRKLRRKVSGKRKS-----------------QSEVTKERED-ECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHREGMLFISKLDGKLSCSEHD 1904          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 498.819 bits (1283), Expect = 6.397e-152
Identity = 293/784 (37.37%), Postives = 406/784 (51.79%), Query Frame = 2
Query:  884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCL--YNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN-----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            S+ KK+ +C +C    +  G++LV+ C G C + FHP+C+       + KE  T       C +C      CF C K+ E D    M +CS + CGRYYH  C+  Y G      + + +  L CP H C  C +D           +RC+ CP ++H GD C+ AGS  I  + IIC  H S                KNG             F+ P N                   V WCF+C  GG+L+CCE CPAS H  C  I+     ++C +C+SG+ P Y  I W+K+G+YRWWP +I +P   P  +    H  G F V FFG++DYYW+N+   FP+ + D    E                    G   +++ ++K+L+ AAK      ++ E+   L+      +P  Y+ IK+N P G V+++  ADL+EIP+C C+P+D+   PC   S+C+NR L YECHP VC  G+ C NQ F +R YP  EV  T  RGW L+T + +KKG FV EYVGELID  E  +R++ A+E +V+NFYM+ L   R+IDAGP  N+SRFMNHSCSPN  TQKW+VNGD RIGLF L  I A  ELTFNYN   LG  +  C CG+ NCSGFLG  PK+A           ++E ++   +     KK+    +             K+  +  CY CG+    + C  + CP+ YHL C++LS  P   W CPWH C  C R +  FC  C  S+C  H   +L  S+ ++   CSNH+
Sbjct:  806 SSSKKDTVCHVC----ETFGDSLVS-CEGDCNRLFHPECM----GSNSGKESETV------CQECKTGSHPCFSC-KVTEGD----MKRCSVNGCGRYYHETCVRKYTG------SASDTKGLRCPQHSCATCCLDRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNHSS--------------SRKNGH------------FSSPVN-------------------VGWCFICARGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAE--------------------GQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHV-ADLSEIPRCNCKPTDE--RPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSCHCGSENCSGFLGVKPKSA----------VVMEREEKVRNAKLKPKKRKLKTES------------KQTHELYCYCCGEGGELVMCDKKDCPKAYHLLCLNLSKPPYGRWECPWHQCSVCQRTATSFCHFCPASFCREHERGQLAVSALDKQPCCSNHD 1473          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:NCBI gene;Acc:100145675])

HSP 1 Score: 507.679 bits (1306), Expect = 4.851e-156
Identity = 291/776 (37.50%), Postives = 389/776 (50.13%), Query Frame = 2
Query:  905 LCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALV-LRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            L FL + +  E    L+  C   C   FH  CL +         P  K +    C +C+     CF+C++  +  K+     C    CG+YYH  C     Y      NR     C  HIC  CY  +P         + RC+ CP ++H  D+C+PAG+  +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CCE CPA+ H+ C  ID     + C+DC++G+ P Y ++ W+K+G YRWWP ++ HP   P  + K  H  G+F V FFG+ DY W ++   FP+ +GD                 + +D    G   +D  Y+K L  AA+    L+  K    L  + KN  KP  Y+ IK N P+G V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  GE C+NQ F +R+YP+ E+F T +RGW LR    IKKG FVNEYVGE+IDE E   R++ A E +++NFYM+ LD  R+IDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     SE   K                              V  +     K  + EC+ CG     + C    CP+VYH +C+ L+  P   W CPWH CD C + +   C  C +S+C  HR   L  S  +  + C+ H+
Sbjct:  658 LLFLVVMQVCEKPGELLL-CEAQCCGAFHLQCLGM------EAMPQGKFV----CTECSSGYHTCFVCKESDQGVKR-----CMLPLCGKYYHEECALK--YPPATQQNRG--FRCSLHICSTCYATNPSNPSASKGRLMRCVRCPIAYHANDFCLPAGAVTLASNSIICPNHF----------TPRRGCKNHEHV-----------------------------------NVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCKAGKKPHYKEVVWVKVGRYRWWPAEVCHPKTIPPNIQKMKHDIGEFPVVFFGSKDYLWTHQARVFPYMEGD----------------ALNKDKMSKG---MDAVYKKGLMEAAERFEELKAQKEMRQLQEDKKNDKKPPPYKHIKVNRPVGKVQI-LTADLSEIPRCNCKATDE--NPCGQDSECINRMLLYECHPSVCPAGERCQNQAFSKRQYPEVEIFRTLSRGWGLRCRTDIKKGEFVNEYVGEMIDEEECRARIRYAQEQDITNFYMLTLDKDRVIDAGPKGNFARFMNHCCQPNCETQKWTVNGDTRVGLFALCDIKAGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPVSSEDKGKK-------------------------RKQYVKRKKSEVVKEHEDECFSCGDGGQLVSCKKPGCPKVYHAECLKLTRRPAGKWECPWHQCDICHKEAASLCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 1321          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:100125213])

HSP 1 Score: 504.597 bits (1298), Expect = 1.033e-155
Identity = 283/781 (36.24%), Postives = 394/781 (50.45%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK  +C +C +  D      +  C G C   FH  C+ L      S  P  K +    C +C    R CF+C++   + K+     C   +CG++YH +CL       L  +   G   CP H C  CY  +P   +      VRC+ CP ++H  + CI AG   +    IIC  H +                                                  +K+KSH    NV+WCF+C +GG L+CCE CPA+ H  C  I+     + C+DC+ G+ PR+ DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +  +G   + + ++ +L+ A      ++R  + +     + KP  Y+ IK N P G V++   AD++EIP+C C+PS +   PCG  SEC+NR LMYECHP VC  G+ C+NQ F +R+YP+ ++  T+ +GW L     IKKG FVNEY+GELIDE E   R++ A E ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  TQKWSVNGDTR+GLFA+  I AGEELTFNYN   LG +K  C+CGA NCSGFLGD PK +S   E   K    + K+   ++                         KK  +  C+RC      + C  + C + YHL C+SL+  P   W CPWH CD CG+ S   CS C  S+C  H  +     + E  +C    D
Sbjct:  615 KKELVCQVCEKVGD------LMLCEGVCCSAFHLSCIGL------STRPAGKYL----CKECTSGARSCFLCKESNRDVKR-----CIVPHCGKFYHESCLRK---YPLAVFESRG-FRCPLHRCATCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFA-------------------------------------------------ANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYT-ADISEIPKCNCKPSSE--KPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKVSSSHEEKVKKPKKKQKKRRTKTDG------------------------KKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD 1275          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:100125213])

HSP 1 Score: 503.056 bits (1294), Expect = 1.216e-155
Identity = 284/783 (36.27%), Postives = 395/783 (50.45%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPK--TASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK  +C +C +  D      +  C G C   FH  C+ L      S  P  K +    C +C    R CF+C+     +   ++ +C   +CG++YH +CL       L  +   G   CP H C  CY  +P   +      VRC+ CP ++H  + CI AG   +    IIC  H +                                                  +K+KSH    NV+WCF+C +GG L+CCE CPA+ H  C  I+     + C+DC+ G+ PR+ DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +  +G   + + ++ +L+ A      ++R  + +     + KP  Y+ IK N P G V++   AD++EIP+C C+PS +   PCG  SEC+NR LMYECHP VC  G+ C+NQ F +R+YP+ ++  T+ +GW L     IKKG FVNEY+GELIDE E   R++ A E ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  TQKWSVNGDTR+GLFA+  I AGEELTFNYN   LG +K  C+CGA NCSGFLGD PK  TAS   E   K    + K+   ++                         KK  +  C+RC      + C  + C + YHL C+SL+  P   W CPWH CD CG+ S   CS C  S+C  H  +     + E  +C    D
Sbjct:  552 KKELVCQVCEKVGD------LMLCEGVCCSAFHLSCIGL------STRPAGKYL----CKECTSGARSCFLCK-----ESNRDVKRCIVPHCGKFYHESCLRK---YPLAVFESRG-FRCPLHRCATCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFA-------------------------------------------------ANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYT-ADISEIPKCNCKPSSE--KPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVKKPKKKQKKRRTKTDG------------------------KKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD 1214          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40])

HSP 1 Score: 500.36 bits (1287), Expect = 2.006e-155
Identity = 289/767 (37.68%), Postives = 398/767 (51.89%), Query Frame = 2
Query:  935 ESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPK-TASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            ES    + +C G C + FH +CL +  D L    P  K I    C++C   +  CF C+    + K+     CS   CG++YH  C      Q   T   S    CP H C +C  D  +  + C    + C+ CP ++H GD CI AGS  ++ + IIC  H    G A                                               S S NV +CF+C  GGKL+CC+ CPA+ H  C  ++     + C+DC+SG+   Y  I W+K+G+YRWWP +I +P + P  +    H  G F V FFG++DYYW+++   FP+ +GD                     +  +G T +++ ++K+L+ AA+      ++ ES   L+      KP  Y+ IK+N P+G V+I + ADL+EIP+C CRP+D  + PCG  +EC+NR L+YECHP +C  GE+C NQ F +R YP+ E+F T+ RGW LRT   I+KG FVNEYVGELIDE E  +R+K+AHE   +NFY++ +   RIIDAGP  N SRFMNHSC+PN  TQKW+VNGD R+GLFAL  I  G ELTFNYN   LG  +  C CGA NCSGFLG  PK T +  +E   K++ L+ KK                             QK++ +  C+RCG     + C  + CP+ YHL C++L+  P   W CPWH CD CG  S  FC  C  S+C  H    L  S+ E   C +  D
Sbjct:  496 ESYGESLVSCDGECSRLFHLECLGM--DTL----PDGKFI----CMECKTGLHTCFSCKIPSTSVKR-----CSAPCCGKFYHETCAR----QYSATIFDSKGFRCPHHCCSSCTADK-DPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHA-----------------------------------------------SSSVNVGFCFVCARGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDK--------------------SFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQI-QLADLSEIPRCNCRPTD--DTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRECHCGAENCSGFLGVRPKVTCATATEERSKNARLKAKKRKLKTE-----------------------QKQMHEDFCFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREHEKGSLTSSALEGRFCCSDHD 1149          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:100125213])

HSP 1 Score: 503.056 bits (1294), Expect = 4.092e-155
Identity = 284/783 (36.27%), Postives = 395/783 (50.45%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPK--TASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK  +C +C +  D      +  C G C   FH  C+ L      S  P  K +    C +C    R CF+C+     +   ++ +C   +CG++YH +CL       L  +   G   CP H C  CY  +P   +      VRC+ CP ++H  + CI AG   +    IIC  H +                                                  +K+KSH    NV+WCF+C +GG L+CCE CPA+ H  C  I+     + C+DC+ G+ PR+ DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +  +G   + + ++ +L+ A      ++R  + +     + KP  Y+ IK N P G V++   AD++EIP+C C+PS +   PCG  SEC+NR LMYECHP VC  G+ C+NQ F +R+YP+ ++  T+ +GW L     IKKG FVNEY+GELIDE E   R++ A E ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  TQKWSVNGDTR+GLFA+  I AGEELTFNYN   LG +K  C+CGA NCSGFLGD PK  TAS   E   K    + K+   ++                         KK  +  C+RC      + C  + C + YHL C+SL+  P   W CPWH CD CG+ S   CS C  S+C  H  +     + E  +C    D
Sbjct:  609 KKELVCQVCEKVGD------LMLCEGVCCSAFHLSCIGL------STRPAGKYL----CKECTSGARSCFLCK-----ESNRDVKRCIVPHCGKFYHESCLRK---YPLAVFESRG-FRCPLHRCATCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFA-------------------------------------------------ANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYT-ADISEIPKCNCKPSSE--KPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVKKPKKKQKKRRTKTDG------------------------KKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD 1271          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 507.679 bits (1306), Expect = 2.628e-156
Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250
            KK  +C LC    +++G+ L+  C G C   FH  CL L      S+ P  +      C +C   +  CF+C+     + K E+ +C  + CG++YH  C+     +  +T   S    CP H C +C+  +P   +     + RC+ CP ++H GD C+ AG   I  N IIC  H +                + G+     VN                              V+WCF+C  GG L+CCE CPA+ H  C  I+     + C+DC++G+   + DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +   G   + R ++ +L+ A      V    +       + KP  Y+ IK N P G V+I   AD++EIP+C C+P+D+  +PCG  SEC+NR LM+ECHP VC  GE C+NQ F +R+YP+ ++  TD +GW L     I+KG FVNEYVGELIDE E   R+K AHE ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  T KW+VNGDTR+GLFA+  I AG ELTFNYN   LG +K  C+CGASNCSGFLGD PKT AS  SE   K +  + ++                              K+  + EC+RCG     + C  + C + YHL C+ L   P   W CPWH CD CG+ S  FC  C  S+C  H+     +S+ +        DL     S T+++
Sbjct:  666 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1340          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 507.679 bits (1306), Expect = 2.628e-156
Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250
            KK  +C LC    +++G+ L+  C G C   FH  CL L      S+ P  +      C +C   +  CF+C+     + K E+ +C  + CG++YH  C+     +  +T   S    CP H C +C+  +P   +     + RC+ CP ++H GD C+ AG   I  N IIC  H +                + G+     VN                              V+WCF+C  GG L+CCE CPA+ H  C  I+     + C+DC++G+   + DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +   G   + R ++ +L+ A      V    +       + KP  Y+ IK N P G V+I   AD++EIP+C C+P+D+  +PCG  SEC+NR LM+ECHP VC  GE C+NQ F +R+YP+ ++  TD +GW L     I+KG FVNEYVGELIDE E   R+K AHE ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  T KW+VNGDTR+GLFA+  I AG ELTFNYN   LG +K  C+CGASNCSGFLGD PKT AS  SE   K +  + ++                              K+  + EC+RCG     + C  + C + YHL C+ L   P   W CPWH CD CG+ S  FC  C  S+C  H+     +S+ +        DL     S T+++
Sbjct:  666 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1340          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 507.294 bits (1305), Expect = 3.005e-156
Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250
            KK  +C LC    +++G+ L+  C G C   FH  CL L      S+ P  +      C +C   +  CF+C+     + K E+ +C  + CG++YH  C+     +  +T   S    CP H C +C+  +P   +     + RC+ CP ++H GD C+ AG   I  N IIC  H +                + G+     VN                              V+WCF+C  GG L+CCE CPA+ H  C  I+     + C+DC++G+   + DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +   G   + R ++ +L+ A      V    +       + KP  Y+ IK N P G V+I   AD++EIP+C C+P+D+  +PCG  SEC+NR LM+ECHP VC  GE C+NQ F +R+YP+ ++  TD +GW L     I+KG FVNEYVGELIDE E   R+K AHE ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  T KW+VNGDTR+GLFA+  I AG ELTFNYN   LG +K  C+CGASNCSGFLGD PKT AS  SE   K +  + ++                              K+  + EC+RCG     + C  + C + YHL C+ L   P   W CPWH CD CG+ S  FC  C  S+C  H+     +S+ +        DL     S T+++
Sbjct:  665 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1339          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581])

HSP 1 Score: 506.523 bits (1303), Expect = 1.207e-155
Identity = 292/779 (37.48%), Postives = 404/779 (51.86%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK+ +C +C    +++G+ LVA C G C + FH +CL L          T     +  C +C      CF C+  G++ K+     CS S CG++YH  C+    +   I    S    CP H C +C ++           +RCL CP ++H GD C+ AGS  ++ + +IC  H                                                  + S+S + NV +CF+C  GG+L+CCE CPAS H  C +ID     + C+DC++G+   Y  I W+K+G+YRWWP +I  P + P  +    H  G F V FFG++DYYW+++   FP+ +GD    E                    G T +++ ++K+L+ AAK      ++ ES   L+      KP  Y+ IK N  IG V++ + ADL+EIP+C C+P D+  +PCG  S+C+NR   YECHP VC  G+ C+NQ F +R YP  EV  T+ RGW LRT   IKKG FVNEYVGELIDE E   R+K+AHE +V+NFYM+ +   RIIDAGP  N SRFMNHSC+PN  TQKW+VNGD R+GLFAL  I AG ELTFNYN   LG  +  C CGA NCSGFLG  PK+A   S   +K    +LKK      +                       K + +  C++CG     + C  + CP+ YHL C++L+  P   W CPWH CD+CG ++  FC  C  S+C  H    LV S+ E  +C +  D
Sbjct:  709 KKDTVCQVC----EKAGDCLVA-CEGECCRHFHVECLGL----------TAVPEGHFTCEECETGQHPCFSCKVSGKDVKR-----CSVSVCGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSK------------------------------------------------RSSQSAAINVGFCFVCARGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQV-QVADLSEIPRCNCKPGDE--NPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSAC-TSAVDEKTKNAKLKKRRKVKAEA----------------------KPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLCCSSHD 1369          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd1 (nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545])

HSP 1 Score: 521.161 bits (1341), Expect = 1.286e-155
Identity = 299/757 (39.50%), Postives = 397/757 (52.44%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C   C   FH +CL L       + P  K I    C +C+  +  CF+C++ GE+ K+     C    CG++YH  C+    Y   +T N+     CP HIC  C+  +P  V      + RC+ CP ++H  D+C+ AGS+ +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CC+ CPA+ H+ C  ID     + C+DC++G+ P Y +I W+K+G YRWWP +I HP   P  + K  H  G+F V FFG+NDY W ++   FP+ +GD  +                +D  G G   +D  Y+K+L+  AA+   L+  K    L  + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  G  C+NQ F +R+YP  E+F T  RGW LRT   IKKG FVNEYVGELIDE E   R++ A E +++NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKWSVNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     +E   +    +      S                     Q    K+  D EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +S+C  HR   L  S  +  + C+ H+
Sbjct: 1456 CEAQCCGAFHLECLGL------PEMPRGKFI----CNECHTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVTQNKG--FRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRS---------------------QGEVTKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2104          
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q8BVE8|NSD2_MOUSE (Histone-lysine N-methyltransferase NSD2 OS=Mus musculus OX=10090 GN=Nsd2 PE=1 SV=2)

HSP 1 Score: 507.294 bits (1305), Expect = 2.102e-155
Identity = 288/790 (36.46%), Postives = 403/790 (51.01%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL--VLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT-ASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQ 3250
            KK  +C LC    +++G+ L+  C G C   FH  CL L      S+ P  +      C +C   +  CF+C+     + K E+ +C  + CG++YH  C+     +  +T   S    CP H C +C+  +P   +     + RC+ CP ++H GD C+ AG   I  N IIC  H +                + G+     VN                              V+WCF+C  GG L+CCE CPA+ H  C  I+     + C+DC++G+   + DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +   G   + R ++ +L+ A      V    +       + KP  Y+ IK N P G V+I   AD++EIP+C C+P+D+  +PCG  SEC+NR LM+ECHP VC  GE C+NQ F +R+YP+ ++  TD +GW L     I+KG FVNEYVGELIDE E   R+K AHE ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  T KW+VNGDTR+GLFA+  I AG ELTFNYN   LG +K  C+CGASNCSGFLGD PKT AS  SE   K +  + ++                              K+  + EC+RCG     + C  + C + YHL C+ L   P   W CPWH CD CG+ S  FC  C  S+C  H+     +S+ +        DL     S T+++
Sbjct:  665 KKEYVCQLC----EKTGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCTECASGIHSCFVCK-----ESKMEVKRCVVNQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA---------------RKGKRHHTHVN------------------------------VSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEG-----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTE 1339          
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q9BZ95|NSD3_HUMAN (Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1)

HSP 1 Score: 508.834 bits (1309), Expect = 2.522e-155
Identity = 296/787 (37.61%), Postives = 418/787 (53.11%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRV-------KLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLK-----NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTA-SPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            KK+ +C +C    + SG++L+  C G C + FH +CL L      +  P +K I    C++C      CF C+  G++ K+     CS   CG++YH  C+    +   I    S    CP H C AC ++           +RCL CP ++H GD CI AGS  ++   +IC  H     ++      F      G +         +S  +K     +  N+   +++ P+  S S S        C  GG+L+CCE CPAS H  C +I+     + C+DC++G+   Y  I W+K+G+YRWWP +I +P + P  +    H  G F V FFG++DYYW+++   FP+ +GD    E                    G T +++ ++K+L+ AAK      ++ ES   L+      KP  Y+ IK N  IG V+I + ADL+EIP+C C+P+D+  +PCG  SEC+NR L YECHP VC  G+ C+NQ F +R YP  E+  T+ RGW LRT   IKKG FVNEYVGELIDE E   R+K+AHE +V+NFYM+ +   RIIDAGP  N SRFMNHSC+PN  TQKW+VNGD R+GLFAL  I AG ELTFNYN   LG  +  C CGA NCSGFLG  PK+A +  +E   K++ L+ K+                              K++ +  C++CG     + C  + CP+ YHL C++L+  P   W CPWH CD+C   +  FC  C  S+C  H    LV S+ E  +C +  D
Sbjct:  699 KKDTVCQIC----ESSGDSLIP-CEGECCKHFHLECLGL------ASLPDSKFI----CMECKTGQHPCFSCKVSGKDVKR-----CSVGACGKFYHEACVRK--FPTAIF--ESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIPSSSASKK-----KCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE--------------------GQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQI-QVADLSEIPRCNCKPADE--NPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEP-----------------------KQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409          
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O88491|NSD1_MOUSE (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Mus musculus OX=10090 GN=Nsd1 PE=1 SV=1)

HSP 1 Score: 522.316 bits (1344), Expect = 3.899e-155
Identity = 298/757 (39.37%), Postives = 396/757 (52.31%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C   C   FH +CL L       + P  K I    C +C+  +  CF+C++ GE+ K+     C    CG++YH  C+    Y   +T N+     CP HIC  C+  +P  V      + RC+ CP ++H  D+C+ AGS+ +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CC+ CPA+ H+ C  ID     + C+DC++G+ P Y +I W+K+G YRWWP +I HP   P  + K  H  G+F V FFG+NDY W ++   FP+ +GD  +                +D  G G   +D  Y+K+L+ AA   + L  R    +   + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  G  C+NQ F +R+YP  E+F T  RGW LRT   IKKG FVNEYVGELIDE E   R++ A E +++NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKWSVNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     +E   +    +      S                     Q    K+  D EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +S+C  HR   L  S  +  + C+ H+
Sbjct: 1456 CEAQCCGAFHLECLGL------PEMPRGKFI----CNECHTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVTQNKG--FRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKARKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRS---------------------QGEVTKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2104          
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q96L73|NSD1_HUMAN (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1)

HSP 1 Score: 518.079 bits (1333), Expect = 1.325e-153
Identity = 297/757 (39.23%), Postives = 397/757 (52.44%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLK-IAAKALVLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C   C   FH +CL L      ++ P  K I    C +C   +  CF+C++ GE+ K+     C    CG++YH  C+    Y   +  N+     C  HIC  C+  +P  V      + RC+ CP ++H  D+C+ AGS+ +  N IICP H           TP   C  +  V                                   NV+WCF+C +GG L+CC+ CPA+ H+ C  ID     + C+DC++G+ P Y +I W+K+G YRWWP +I HP   P  + K  H  G+F V FFG+NDY W ++   FP+ +GD  +                +D  G G   +D  Y+K+L+  AA+   L+  K    L  + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+  +PCG  SEC+NR L+YECHP VC  G  C+NQ F +R+YP+ E+F T  RGW LRT   IKKG FVNEYVGELIDE E   R++ A E +++NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKWSVNGDTR+GLFAL  IKAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK     +E   K    + +    +                     Q    K+  D EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +S+C  HR   L  S  +  + C+ H+
Sbjct: 1558 CEAQCCGAFHLECLGL------TEMPRGKFI----CNECRTGIHTCFVCKQSGEDVKR-----CLLPLCGKFYHEECVQK--YPPTVMQNKG--FRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHF----------TPRRGCRNHEHV-----------------------------------NVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS----------------KDKMGKG---VDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT-ADLSEIPRCNCKATDE--NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT---------------------QGEITKERED-ECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2206          
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O96028|NSD2_HUMAN (Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1)

HSP 1 Score: 501.516 bits (1290), Expect = 3.256e-153
Identity = 280/763 (36.70%), Postives = 392/763 (51.38%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAA---KALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHR 3157
            KK  +C LC    ++ G+ L+  C G C   FH  CL L      S+ P  +      C +C   +  CF+C+     + K ++ +C  + CG++YH  C+     +  +T   S    CP H C +C+  +P   +     + RC+ CP ++H GD C+ AG   I  N IIC  H +                                                   K K H    NV+WCF+C  GG L+CCE CPA+ H  C  I+     + C+DC++G+   + DI W+K+G+YRWWP ++ HP N P  + K  H  G+F V FFG+ DYYW ++   FP+ +GD                   R +   G   + R ++ +L+ A    + + L+    E+    + KP  Y+ IK N P G V+I   AD++EIP+C C+P+D+  +PCG  SEC+NR LM+ECHP VC  GE C+NQ F +R+YP+ ++  TD +GW L     I+KG FVNEYVGELIDE E   R+K AHE ++++FYM+ +D  RIIDAGP  N SRFMNHSC PN  T KW+VNGDTR+GLFA+  I AG ELTFNYN   LG +K  C+CGASNCSGFLGD PKT++  S         +  +   +  +                       K+  + EC+RCG     + C  + C + YHL C+ L   P   W CPWH CD CG+ S  FC  C  S+C  H+
Sbjct:  665 KKEYVCQLC----EKPGSLLL--CEGPCCGAFHLACLGL------SRRPEGR----FTCSECASGIHSCFVCK-----ESKTDVKRCVVTQCGKFYHEACVK----KYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFT-------------------------------------------------ARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGD-------------------RGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARET-QESERKPPPYKHIKVNKPYGKVQIYT-ADISEIPKCNCKPTDE--NPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEG----------------------KRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQ 1308          
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A267ERM7 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig026212g1 PE=4 SV=1)

HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0
Identity = 325/820 (39.63%), Postives = 445/820 (54.27%), Query Frame = 2
Query:  851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256
            FEFQ L L   S+ K+ P+C  C     E G  ++      C  QFH  CL        +           KC DC    + CF+C K    DK+  M++C  + CG+ YH  C  +  + ++     S  L CP H C AC +D P +    S         VRC+ CP+++H GD+C+PAGS E+++  I+CP+HL                                                 +   +K+ NV WCF+C  GG L+CCERCPAS H  C  + E+P  F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP  + + +H  G F V FFGT++YYW++K   F FEDGD   G+++K                 G+++L + +++ +++A +A  L     E+   +    KP  Y+ I+TN P GN R+ K ADL+E+ +C+C  S    +PCG  S+CMNR L YECHP +C   + C NQRF++REYP Q VF T+   RGW L+ ++ I KG FVNEYVG+LIDE EA +RL  AH+  V+NFYM+ LD  RIIDAGP  N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL  IKAGEELTFNYNF  LG +KL C+CGA NCSGFLG  P++++     +   S        +      K++ +       T        K + +  CYRC      I C  + CP+VYHL C+ LS  P   W CPWH CD+CGR +   CSEC  SYC  H  +R+ +             VC  H+DL +++ +    +NG
Sbjct:  335 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1064          
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A1I8IAL6 (Histone-lysine N-methyltransferase OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 325/820 (39.63%), Postives = 445/820 (54.27%), Query Frame = 2
Query:  851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256
            FEFQ L L   S+ K+ P+C  C     E G  ++      C  QFH  CL        +           KC DC    + CF+C K    DK+  M++C  + CG+ YH  C  +  + ++     S  L CP H C AC +D P +    S         VRC+ CP+++H GD+C+PAGS E+++  I+CP+HL                                                 +   +K+ NV WCF+C  GG L+CCERCPAS H  C  + E+P  F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP  + + +H  G F V FFGT++YYW++K   F FEDGD   G+++K                 G+++L + +++ +++A +A  L     E+   +    KP  Y+ I+TN P GN R+ K ADL+E+ +C+C  S    +PCG  S+CMNR L YECHP +C   + C NQRF++REYP Q VF T+   RGW L+ ++ I KG FVNEYVG+LIDE EA +RL  AH+  V+NFYM+ LD  RIIDAGP  N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL  IKAGEELTFNYNF  LG +KL C+CGA NCSGFLG  P++++     +   S        +      K++ +       T        K + +  CYRC      I C  + CP+VYHL C+ LS  P   W CPWH CD+CGR +   CSEC  SYC  H  +R+ +             VC  H+DL +++ +    +NG
Sbjct:  343 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1072          
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A267FZR2 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014479g2 PE=4 SV=1)

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 325/820 (39.63%), Postives = 445/820 (54.27%), Query Frame = 2
Query:  851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256
            FEFQ L L   S+ K+ P+C  C     E G  ++      C  QFH  CL        +           KC DC    + CF+C K    DK+  M++C  + CG+ YH  C  +  + ++     S  L CP H C AC +D P +    S         VRC+ CP+++H GD+C+PAGS E+++  I+CP+HL                                                 +   +K+ NV WCF+C  GG L+CCERCPAS H  C  + E+P  F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP  + + +H  G F V FFGT++YYW++K   F FEDGD   G+++K                 G+++L + +++ +++A +A  L     E+   +    KP  Y+ I+TN P GN R+ K ADL+E+ +C+C  S    +PCG  S+CMNR L YECHP +C   + C NQRF++REYP Q VF T+   RGW L+ ++ I KG FVNEYVG+LIDE EA +RL  AH+  V+NFYM+ LD  RIIDAGP  N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL  IKAGEELTFNYNF  LG +KL C+CGA NCSGFLG  P++++     +   S        +      K++ +       T        K + +  CYRC      I C  + CP+VYHL C+ LS  P   W CPWH CD+CGR +   CSEC  SYC  H  +R+ +             VC  H+DL +++ +    +NG
Sbjct:  335 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1064          
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A1I8H0A0 (Histone-lysine N-methyltransferase OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 580.096 bits (1494), Expect = 0.000e+0
Identity = 325/833 (39.02%), Postives = 445/833 (53.42%), Query Frame = 2
Query:  851 FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-------VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPD-------------GGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES--ILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTD--NRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENM-------VCSNHEDLFLSHGSPTESQNG 3256
            FEFQ L L   S+ K+ P+C  C     E G  ++      C  QFH  CL        +           KC DC    + CF+C K    DK+  M++C  + CG+ YH  C  +  + ++     S  L CP H C AC +D P +    S         VRC+ CP+++H GD+C+PAGS E+++  I+CP+HL                                                 +   +K+ NV WCF+C               GG L+CCERCPAS H  C  + E+P  F CDDC+ GR PRYGDI W+K+G +RWWP +I++P++AP  + + +H  G F V FFGT++YYW++K   F FEDGD   G+++K                 G+++L + +++ +++A +A  L     E+   +    KP  Y+ I+TN P GN R+ K ADL+E+ +C+C  S    +PCG  S+CMNR L YECHP +C   + C NQRF++REYP Q VF T+   RGW L+ ++ I KG FVNEYVG+LIDE EA +RL  AH+  V+NFYM+ LD  RIIDAGP  N+SRFMNHSCSPN+ TQKWSVNGD RIGLFAL  IKAGEELTFNYNF  LG +KL C+CGA NCSGFLG  P++++     +   S        +      K++ +       T        K + +  CYRC      I C  + CP+VYHL C+ LS  P   W CPWH CD+CGR +   CSEC  SYC  H  +R+ +             VC  H+DL +++ +    +NG
Sbjct:  343 FEFQRL-LHAPSSVKRAPVCSKC-----ELGGEVIP--CDSCCLQFHAVCLADGAAAADA---ADGEAGAKKCADCAAGRQLCFLC-KQDAGDKR--MLRCHINGCGKQYHDACAGSMPFAKV----ESRGLVCPQHACLACCVDAPSSAPGSSGRATGAAKLVRCVRCPAAYHGGDFCVPAGSEELSETCIVCPEHL-------------------------------------------------RDKAAKTINVAWCFICSQIPGFIFNLLLFTQGGSLVCCERCPASFHPECLKLSELPEQFTCDDCRMGRQPRYGDIVWVKVGHFRWWPCEILYPDHAPLNIQRMAHQKGTFPVHFFGTDEYYWVHKGRVFEFEDGD--LGDLRKT---------------QGSSRLVQLFKEGVRLAQEACRLFREMRENRDKMEQSKKPPPYKFIRTNYPFGNARVYKAADLSELHRCDC--SADSQEPCGSDSDCMNRVLYYECHPGLCAAKDRCLNQRFVKREYPTQAVFKTNQGGRGWGLKAMQDIAKGEFVNEYVGDLIDEEEAKKRLSWAHDHGVTNFYMLTLDKGRIIDAGPKGNLSRFMNHSCSPNLVTQKWSVNGDLRIGLFALRDIKAGEELTFNYNFECLGAEKLACQCGAENCSGFLGVRPRSSANLLRDAAASSGGGGGGGGDGAESGKKRRRTKGVASGTT----GAVCKVVYEDTCYRCCDGGEMIMCDKEACPKVYHLGCLGLSKAPSGKWYCPWHHCDECGRPATVLCSECPGSYCAEHADSRIFQMPAGTAAGGGVINVCCEHDDLLVAYQASEGKENG 1085          
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A2T7PCE1 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_10357 PE=4 SV=1)

HSP 1 Score: 562.762 bits (1449), Expect = 4.914e-173
Identity = 319/805 (39.63%), Postives = 440/805 (54.66%), Query Frame = 2
Query:  848 NFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSG-SLTCPSHICHACYIDD---PEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV-VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVL-RTSKW--ESILNLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLF 3220
            ++  +  KL +    KK  +C +C     E    L+  C G C   FH  CL+L       KEP        +C +C   +  CF C+K     +  E+ +CS S CG++YH  C+     ++L      G    CP H+C  C  D+   P+AVK     +RC+ CP+++H GD+CI AGS+ +   +I+C  H                                               KPLK   S++H    NV+WCF C  GG L+CCE CPA+ H  CA +D +P   + C DC  G+ P YGDI W+KIG+YRWWPG+I HP N P  + + +H  G+F V+FFG++D+YW ++   F F++GD  +   K I A   L ++               Y K +K A +A  L + +K   E +   +N  KP+ Y+ +K NVP+GNV+I+K ADL+EIP+CECRP  +  +PCG  +EC+NR LMYECHP VC   E+C NQRF +R+YP    + T++RGW L+TL  IKKG FV EYVG+L+DE E  RR+ +AHE N++NFYM+ LD  RIIDAGP  N SRFMNHSC PN+ TQKW+VNGD R+GLF L  I AG ELTFNYN   LG +K  C CG+  CSGFLG  PKTA+                          +K    K        +    KK  + EC+RCG+    + C   +CP+VYHLQC++L+  P   WLCPWH CD CG+++   CSEC  S+C  H  + ++ + N+++VC+ H DL 
Sbjct:  572 DYVLEIFKLNSAGPPKKENICTVC-----EQAGELI-ECHGPCQSYFHTSCLKL------EKEPEAD----FRCSECCAGIHSCFACKK-----QDKEVRRCSVSQCGKFYHEECV-----KKLPQARMEGKGFICPLHVCATCAADNIRNPKAVK--GRLLRCVRCPTAYHVGDFCIAAGSKHLAGYHIVCSGHF----------------------------------------------KPLK---SQAHHVRINVSWCFSCSKGGSLVCCETCPAAFHIECAHLDSMPEDAWYCSDCAHGKRPLYGDIIWIKIGNYRWWPGEICHPRNVPVNIQEKAHQVGEFPVRFFGSHDFYWTHQGRVFLFQEGDRGS---KDISACRGLFKM---------------YCKGVKEATEAFKLWKAAKMNKEQLEQERNDRKPAPYKFVKANVPVGNVQIHK-ADLSEIPRCECRPDQE--NPCGSDTECLNRMLMYECHPQVCPAKESCHNQRFQKRQYPDLLPYRTESRGWGLKTLMDIKKGQFVIEYVGDLVDEDECKRRIAQAHEENITNFYMLTLDKNRIIDAGPKGNYSRFMNHSCEPNLETQKWTVNGDIRVGLFTLKDIPAGSELTFNYNLECLGNEKTKCSCGSDICSGFLGVRPKTAA----------------------AAHMEKRKREKDARKKKKKKKLDVKKEHEDECFRCGEGGELVMCDKPNCPKVYHLQCLNLAKPPHGKWLCPWHHCDVCGKLANKLCSECPNSFCQQH-ADGVISNINDSLVCAEHTDLI 1255          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3])

HSP 1 Score: 519.62 bits (1337), Expect = 1.493e-156
Identity = 297/761 (39.03%), Postives = 403/761 (52.96%), Query Frame = 2
Query:  962 CTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKAL-VLRTSKWESIL--NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLV---DQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            C G C   FH  C+ L      S+ P  + +    C +C   +  CF+C+  GE+     + +C    CG++YH+ C+    Y      NR     C  H+C ACYI +P         + RC+ CP ++H  D+C+ AGS  + +N I+CP H +                                              P K  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P+Y DI W+K+G YRWWP ++  P N PE +L+  H  G+F V FFG+ DY W  +   FP+ +GD            S+++++ + T        D  Y+K+L  AA+    L+  K    L  + KN  KP  Y+ IK N PIG V+I   ADL+EIP+C C+ +D+   PCG  SEC+NR LMYEC+P VC  GE C+NQ F +REY   E+F T +RGW LR++  IKKGAFV+EYVGE+IDE E   R+K A + ++SNFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLFAL  I AG ELTFNYN   LG  K  CKCGA NCSGFLG  PK   P     DK   L+                         V  +   Q +++   + EC+ CG +   I C    CP+VYH  C++L+  P   W CPWH C++CGR +  FC  C  SYC  HR   L  S  +  + CS H+
Sbjct: 1221 CEGHCCGAFHLQCIGL------SEMPRGRFV----CKECKSGLHTCFVCKLSGED-----VRRCMVPVCGKFYHAECILK--YAPTAPQNRG--FRCSLHVCLACYITNPNNPSISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSILCPNHFT----------------------------------------------PRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQDSWYCNDCRAGKKPQYKDILWVKVGRYRWWPAEVTLPKNVPENILRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGD-----------ASNIEKMGKGT--------DAVYKKALNEAAERFRELQAEKEMRQLQEDRKNDKKPPPYKHIKVNRPIGKVQILT-ADLSEIPRCNCKATDET--PCGMDSECINRMLMYECNPQVCAAGERCQNQCFTKREYSPVEIFRTLSRGWGLRSVSEIKKGAFVSEYVGEMIDEEECRARIKHAQDNDISNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALEDIGAGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPPS---EDKGRKLK-----------------------KRVSGKRKSQSEVIKEREDECFYCGDSGQIISCKKPGCPKVYHADCLNLNKRPAGRWECPWHQCNECGREAASFCEMCPNSYCKQHRDGMLFISKLDGKLSCSEHD 1868          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2])

HSP 1 Score: 482.641 bits (1241), Expect = 1.105e-155
Identity = 269/662 (40.63%), Postives = 358/662 (54.08%), Query Frame = 2
Query: 1319 VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN------KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHEDLFLSHGSPTESQNGSINATLSI 3280
             RC+ CP ++H  D+CIPAGS  + +N I+CP H                                                P K  ++  H NV+WCF+C +GG L+CCE CPA+ H+ C  ID     + C+DC++G+ P Y ++ W+K+G YRWWP ++ +P N PE +L+  H  G+F V FFG+NDY W  +   FP+ +GD          ANS      ++  G G   +D  Y+K+L+ AAK      ++ E +  L+       KP  Y+ IK N PIG V+I   ADL+EIP+C CR +D+   PCG  SEC+NR L+YEC+P VC  GE C+NQRF++REY + E+F T +RGW LR    IKKG FVNEYVGE+IDE E   R+++A E ++ NFYM+ LD  RIIDAGP  N +RFMNHSC PN  TQKW+VNGDTR+GLFAL  I  G ELTFNYN   LG  K  CKCGA NCSGFLG  PK   P  +   K     +K+                         Q     K  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ S  FC  C +SYC+ HR   L  S  +  + CS H+        P E +    + T+S+
Sbjct:   16 TRCVRCPIAYHATDYCIPAGSVILANNLILCPNHFI----------------------------------------------PRKGCRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKNIPENILRMRHDVGEFPVLFFGSNDYLWTYQARVFPYMEGD----------ANS------KEKMGKG---VDSVYKKALEEAAKRFQELQAEKE-LRQLQEDRRNDKKPPPYKHIKANRPIGKVQIIT-ADLSEIPRCNCRATDE--SPCGMDSECINRMLLYECNPQVCPAGEKCQNQRFLKREYSEVEIFRTLSRGWGLRGCHDIKKGDFVNEYVGEVIDEEECRARIRQAQENDIGNFYMLTLDKDRIIDAGPKGNEARFMNHSCQPNCETQKWTVNGDTRVGLFALVDISTGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPSDDKGRKKRKGYMKRK------------------------QQQEVTKEREDECFSCGDGGQMVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQESASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHDPCGPDPLEPGEIREYPGSETVSL 584          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 505.753 bits (1301), Expect = 1.597e-155
Identity = 299/809 (36.96%), Postives = 400/809 (49.44%), Query Frame = 2
Query:  884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLP 3301
            ++ KK  +C +C    +++  +LV  C G C   +H  CL L         PT KV+    C  C   V  CF C++      + E+ +CS  +CG+YYH  CL       L  ++  G   CP H C +C+  +    K      +RCL CP ++H GD C+ AGS  +    I+C  H                                  FN            P K     SH NV+WCF+C  GG+L+CCE CPA+ H  C  I      + C+DC+SG+ P+Y DI W+K+G+YRWWP +I HP N P  +    H  G+F V FFG+ DY+W ++   FP+ +GD  +   +                 NG  K+ +      +   K + +     E+  N K KP  Y+ IKTN P G V+I   AD++EIP+C C+P+D+   PC   SEC+NR L+YECHP VC  GE C NQ F +R YP+ +   T  +GW L TL  IKKG FVNEYVGELIDE E   R++ A E ++++FYM+ ++  RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFA+  I  G ELTFNYN   LG +K  C+CGA NCSGFLGD PK A      S        K+   S                          KK  + EC+RCG     + C  + C + YHL C+  +  P   W CPWH CD CG+ S+ FC  C  S+C  H    L        + C  H+D  L   +    +       LS T   SLP
Sbjct:  678 ASVKKESVCQVC----EKTSEDLV-TCEGHCFATYHLQCLGL-------DHPTDKVL----CTACRTGVHACFTCKQ-----SEGEVKRCSVLHCGKYYHEACL---RLSALTVFDNRG-FRCPLHTCLSCHYSNRGTAKATKGKMIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNH----------------------------------FN------------PKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNYRWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRGSRHQR-----------------NGIGKVFKTALLEAETRFKQIKMEREAKEAHENNK-KPPPYKYIKTNKPCGRVQIYT-ADISEIPKCNCKPTDE--RPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLGDRPKIAPTSESKSKPQKKKPRKRRARSEG------------------------KKQSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKPSDAFCQHCPNSFCKAHEEGALRPHPVTSRLCCQEHDDTDLQASAEAAKE-------LSSTSQASLP 1363          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 506.138 bits (1302), Expect = 5.107e-155
Identity = 298/809 (36.84%), Postives = 400/809 (49.44%), Query Frame = 2
Query:  884 SNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLP 3301
            ++ KK  +C +C    +++  +LV  C G C   +H  CL L         PT KV+    C  C   V  CF C++      + E+ +CS  +CG+YYH  CL       L  ++  G   CP H C +C+  +    K      +RCL CP ++H GD C+ AGS  +    I+C  H                                  FN            P K     SH NV+WCF+C  GG+L+CCE CPA+ H  C  I      + C+DC+SG+ P+Y DI W+K+G+YRWWP +I HP N P  +    H  G+F V FFG+ DY+W ++   FP+ +GD  +   +                 NG  K+ +      +   K + +     E+  N K KP  Y+ IKTN P G V+I   AD++EIP+C C+P+D+   PC   SEC+NR L+YECHP VC  GE C NQ F +R YP+ +   T  +GW L TL  IKKG FVNEYVGELIDE E   R++ A E ++++FYM+ ++  RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFA+  I  G ELTFNYN   LG +K  C+CGA NCSGFLGD PK A                           +  S  +K            KK  + EC+RCG     + C  + C + YHL C+  +  P   W CPWH CD CG+ S+ FC  C  S+C  H    L        + C  H+D  L   +    +       LS T   SLP
Sbjct:  725 ASVKKESVCQVC----EKTSEDLV-TCEGHCFATYHLQCLGL-------DHPTDKVL----CTACRTGVHACFTCKQ-----SEGEVKRCSVLHCGKYYHEACL---RLSALTVFDNRG-FRCPLHTCLSCHYSNRGTAKATKGKMIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNH----------------------------------FN------------PKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNYRWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRGSRHQR-----------------NGIGKVFKTALLEAETRFKQIKMEREAKEAHENNK-KPPPYKYIKTNKPCGRVQIYT-ADISEIPKCNCKPTDE--RPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLGDRPKIAP------------------------TSESKSKPQKKKPRKRRARSEGKKQSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKPSDAFCQHCPNSFCKAHEEGALRPHPVTSRLCCQEHDDTDLQASAEAAKE-------LSSTSQASLP 1410          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 410.994 bits (1055), Expect = 7.036e-122
Identity = 215/536 (40.11%), Postives = 300/536 (55.97%), Query Frame = 2
Query: 1625 GGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKN-----KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASP-DSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            GG+L+CCE CPAS H  C  I+    V++C +C++G+ P Y  I W+K+G+YRWWP +I +P   P  +    H  G F V FFG++DYYW+++   FP+ + D    E                    G   +++ ++K+L+ AAK      ++ E+   L+      +P  Y+ IK N P+G V+++  ADL+E+P+C CRP+D+   PCG  S+C+NR L YECHP VC   E C NQ F +R YP  EV  T  RGW L+T + +KKG F+ EYVGELID  E  +R+  A++ +++NFYM+ L   R+IDAGP  N+SRFMNHSCSPN  TQKW+VNGD RIGLF L  I A  ELTFNYN   LG  +  C CGA NCSGFLG  PK+A   + E   K+S L+ KK                              ++  +  C+ CG+    + C  + CP+ YHL C++L+  P   W CPWH C  C R +   C  C  S+C  H   +L  S+ + + C +  D
Sbjct:  759 GGRLLCCEACPASFHPSCLNIEMPEGVWLCSECRAGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDVGDFPVFFFGSHDYYWIHQGRVFPYVESDKNFAE--------------------GQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKANKPVGKVQVHV-ADLSEVPRCNCRPTDE--RPCGQDSQCLNRMLQYECHPQVCPAAERCLNQSFSKRVYPDTEVIKTSGRGWGLKTKQDLKKGDFIMEYVGELIDLEECRQRISHANKNHITNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDIRIGLFTLCDIAADTELTFNYNLDCLGNGRTSCHCGAENCSGFLGVRPKSAVVMEREEKVKNSKLKAKKRKLKLES-----------------------RQTHEYYCFCCGEGGELVMCDRKDCPKAYHLLCLNLTKPPYGRWECPWHQCSVCQRPASASCQFCPESFCREHEAGQLKVSAQDGLPCCSKHD 1248          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 494.582 bits (1272), Expect = 4.371e-153
Identity = 281/790 (35.57%), Postives = 399/790 (50.51%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCP-----------DGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLR----TSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHED 3214
            K++ LC  C    +++G   + +C G C   FH +CL +         P  KV+    C +C+  +  CF C+  G      E+ +C+ S+CGR+YH  C+                  CP H+C +C++  P + +     + RC+ CP ++H  D C+ AGS+ ++   I+C  H +              C    R  + +      P  D     F      L     +S  +    + P            GG L+CCE CPA+ H  C  ++     + C +C++G+ P+Y DI W+K+G+YRWWP +I  P N P+ +    H  GQF VQFFG++DYYW  +   FP+ +GD  + + K    N +                    R  L+ AA+   L+    T + +     + KP  Y+ IK+N P+G V++   AD++EIP+C C+P+D+   PCG  SEC+NR L YECHP +C  G+ C+NQ F +R YP  ++  T  RGW L TL  I+KG FVNEYVGELIDE E  +R+K AHE N+SNFYM+ ++  RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFA   I  G ELTFNYN   LG +K  CKCGA NCSGFLG  PKTA+  +            +      +  + +                      + ECYRCG     + C  + CP+ YHL C++L+  P   W CPWH CD CGR S   C  C  S+C  H+   L + + +  +C    D
Sbjct:  564 KRDALCLAC----EKTGGGSLVSCEGQCCGTFHVECLGV------QTAPGDKVM----CNECSTGLHVCFACKCAGA-----EVRRCAVSSCGRFYHEECVQRSSAAVF----EGRRFRCPLHVCLSCHLAYPASSRASRGRMQRCVRCPVAYHTSDSCLAAGSKVLSPYSIVCSGHFTPNKRDSTWHVNVNWCFLCSRGVIGA------PLPDAGLALFEQSSHYLLSEYKRSSELGKLPMIPVVPAAAAKACGKGGCLLCCESCPAAFHPECLGMEPPEGTWCCAECRAGKKPQYHDIVWVKLGNYRWWPAEICQPRNIPQNIQNLKHTVGQFPVQFFGSHDYYWTTQGRVFPYMEGDKGSTDYKTNCLNKTFK------------------RALLEAAARYQALKAQRETREAQETERSERKPPTYKHIKSNKPVGRVQVYT-ADVSEIPRCNCKPTDE--SPCGLDSECLNRMLQYECHPSICPAGDRCQNQAFTKRAYPPSQIVKTAGRGWGLLTLVSIRKGEFVNEYVGELIDEEECRKRIKYAHEKNLSNFYMLTIEKDRIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFATSDIATGTELTFNYNLDCLGNEKTICKCGAPNCSGFLGVRPKTAAAAATEEKAKKAKRKARGRRPRTETARAEH---------------------EDECYRCGDGGELVMCDKKACPKAYHLSCLNLTKPPFGKWECPWHHCDVCGRPSVRSCELCPNSFCKEHQAGLLTRLTRDGRICCEEHD 1282          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003690.1 (pep scaffold:Pmarinus_7.0:GL484755:705:3732:1 gene:ENSPMAG00000003373.1 transcript:ENSPMAT00000003690.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 155.992 bits (393), Expect = 8.373e-43
Identity = 92/230 (40.00%), Postives = 116/230 (50.43%), Query Frame = 2
Query: 2543 RIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLW------LCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVC-SNHE 3211
            RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFA+  I  G ELTFNYN   LG +K  C CGA NCSGFLG  PK     S   DK    + +K                               K+ D ECYRC      + C H++C + +HL C++L  +P+  W      L     C   G+ +  FC  C +S+C  H    L +SS+ +  C + HE
Sbjct:    3 RIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFAVSDIPCGTELTFNYNLDCLGNEKTVCMCGAPNCSGFLGVRPKRVRAQSAVVDKKPKRKYRKRKVRA-------------------------DKVHDSECYRCKDGGELVMCDHRNCTKTFHLACLNLGTLPEGKWAPRTLPLPHATRCRRSGKTAVAFCQICPSSFCKQHSLGALRRSSDGHHRCFAEHE 207          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005461.1 (pep scaffold:Pmarinus_7.0:GL477205:1717:42601:-1 gene:ENSPMAG00000004962.1 transcript:ENSPMAT00000005461.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 132.88 bits (333), Expect = 2.052e-31
Identity = 82/209 (39.23%), Postives = 109/209 (52.15%), Query Frame = 2
Query: 2177 KPADLTEIPQCEC-RPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQ-EVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAE----ANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKW--SVNGDTRIGLFALHTIKAGEELTFNYNFFSL-GQKKLPCKCGASNCSGFLG 2776
            KP    E   C C RP +  +  C  T  C+NR +  EC    C  GE C N+RF R+E     E F T +RGW +RT    +    + EY+GE++ EA     A R    A     +  Y ++LD   +ID+    N +RF+NHSC PN   QKW  SVNG  RIGLFAL  I    ELT++YNF +   + + PC CG+ NC   +G
Sbjct: 1107 KPLSGCEPVSCSCKRPEETEDSAC--TEGCLNRLVYAECVQSSCPCGELCTNRRFQRQERSAGLERFRTTDRGWGVRTTHHFQANDLIIEYLGEVLSEANFRAFAPRSRMLAQRGEQAGMYCVQLDSGVVIDSYRMGNEARFINHSCQPNCEMQKWCVSVNGIYRIGLFALKDIPISTELTYDYNFHTFTAESQRPCLCGSPNCRNVIG 1313          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: SUV39H2 (suppressor of variegation 3-9 homolog 2 [Source:HGNC Symbol;Acc:HGNC:17287])

HSP 1 Score: 105.916 bits (263), Expect = 2.891e-24
Identity = 72/196 (36.73%), Postives = 98/196 (50.00%), Query Frame = 2
Query: 2279 MYECHPLVCRNGENCRNQRFMRREYPKQE-VFSTDN-RGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELD---GQRIIDAGPAANISRFMNHSCSPNVYTQKWSVN----GDTRIGLFALHTIKAGEELTFNYNFFSLGQK----------------------KLPCKCGASNCSGFL 2773
            +YEC+ L C+ G  C+N R +++  P    +F TDN RGW ++T++ IKK +FV EYVGELI   EA RR         +  Y+ +LD       +DA    NIS F+NHSC PN+      +N       RI  FA+  + AGEELTF+YN      +                      ++ CKCGAS C  FL
Sbjct:  229 IYECNSL-CQCGPECKN-RVVQKGIPFPLCIFRTDNGRGWGVKTMQKIKKNSFVMEYVGELIPSEEAERRGVIYDRAGTT--YLFDLDFCKDDYTVDATFYGNISHFVNHSCEPNLQVYSTFINNHDFSQPRIAFFAMDDLAAGEELTFDYNIKDSSSQNESCNKDTVLHTTVTTSPKQRARITCKCGASTCRKFL 420          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: setd1a (SET domain containing 1A, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-080521-4])

HSP 1 Score: 103.605 bits (257), Expect = 2.097e-22
Identity = 53/149 (35.57%), Postives = 85/149 (57.05%), Query Frame = 2
Query: 2333 RFMRREYPKQEVFSTDNR--GWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFL 2773
            +F + ++ K+++  T +R   W L  LEPI     V EYVG+ I +  A+ R K+     + + Y+  +D   IIDA    N++RF+NHSC+PN Y +  +V    RI +++   I   EE+T++Y  F + + K+PC CGA +C G L
Sbjct: 1706 KFNQLKFRKKKLRFTKSRIHEWGLFALEPIAAEEMVIEYVGQGIRQLVADMREKRYEVEGIGSSYLFRVDHDTIIDATKVGNLARFINHSCNPNCYAKVITVESQKRIVIYSKQAINVNEEITYDYK-FPIEENKIPCLCGAEHCRGTL 1853          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: RPS18B (Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004488])

HSP 1 Score: 191.43 bits (485), Expect = 9.127e-57
Identity = 87/137 (63.50%), Postives = 114/137 (83.21%), Query Frame = 1
Query: 3472 MSLIMPQK--FNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSL++ ++  F HILR++NTN+DG   IVYALT I+GVGRR++++VCKKA+VD++KRAGE+T +ELE+I  +M NPT YKIP WFLNRQ DI DG +   +AN +++KLR+DLERLKKI+ HRG+RH WGLRVRGQH
Sbjct:    1 MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQH 137          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: RPS18A (Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress [Source:SGD;Acc:S000002858])

HSP 1 Score: 191.43 bits (485), Expect = 9.127e-57
Identity = 87/137 (63.50%), Postives = 114/137 (83.21%), Query Frame = 1
Query: 3472 MSLIMPQK--FNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSL++ ++  F HILR++NTN+DG   IVYALT I+GVGRR++++VCKKA+VD++KRAGE+T +ELE+I  +M NPT YKIP WFLNRQ DI DG +   +AN +++KLR+DLERLKKI+ HRG+RH WGLRVRGQH
Sbjct:    1 MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQH 137          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: SET2 (Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000003704])

HSP 1 Score: 152.14 bits (383), Expect = 3.800e-38
Identity = 83/230 (36.09%), Postives = 121/230 (52.61%), Query Frame = 2
Query: 2138 IKTNVPIGNVRINKPADLTEIPQCECRP--SDKCNDPCGPTSECMNRELMYECHPLVCRN-GENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSD 2818
            I  N  IG  + N      +  +C+C    SD  N  C   S+C+NR  + EC   +C + G +C+NQRF +++Y    +F T ++G+ +R  + I+   F+ EY GE+I+E E   RL    + +  +FY M L     IDA    +++RF NHSCSPN Y  KW V    R+G+FA   I  GEE+TF+YN    G +   C C   NC GFLG   +T +    P +
Sbjct:   51 IYANKRIGTFKNN------DFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQN 274          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: SET1 (Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain [Source:SGD;Acc:S000001161])

HSP 1 Score: 100.523 bits (249), Expect = 9.884e-22
Identity = 51/130 (39.23%), Postives = 71/130 (54.62%), Query Frame = 2
Query: 2390 WALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSL--GQKKLPCKCGASNCSGFL 2773
            W L  L+ I     + EYVGE I +  A  R K+  +  + + Y+  +D   +IDA     I+RF+NH C PN   +   V G  RI ++AL  I A EELT++Y F      +++LPC CGA NC GFL
Sbjct:  950 WGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFL 1079          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO43156 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZJ4])

HSP 1 Score: 420.239 bits (1079), Expect = 1.602e-131
Identity = 258/758 (34.04%), Postives = 369/758 (48.68%), Query Frame = 2
Query:  968 GGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH----NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPV-VFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPD-SEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFL 3223
            G C   +HPDC+ L      S  P  K     KC +C   V  CF+C++ G+      +  CS   C ++YH  CL +    ++        + CP H C  C I +   V +     +C+ CP+++H G  C+ AG   I  + +                                                 V  K    +KSK+H    NV WCF+C  GG LICCE CPA+ H  C + + IP   F C DC  G+   YGDI W+K+G YRWWP  I +P + P  +    H  G+F V F G++D+YW++K   F ++DGD  T        N  L +V +        K D +++K+ +  A+  + R  K         KP QY+ IKTN      RI    D +E+P CEC P    +  CG  + C+N  L +EC    C  G+ C+NQRF +R+Y   E F   +RGW LR+ + IKKG FV EYVGELID+A    R+KK  +   +N+YM+ +D   IIDAGP  N+SRFMNHSC PN  TQKW+VNG+ R+GLF    +++ EELTF+Y     G +K  C CG+ NCSGFLG  PKT +   +E   K++ L+ +K       +                      K++ + +C+ CG     I C    C + YH+ C++L   P+  W CPWH CD+CG+ +   CSEC  S+C  H   ++  +     +C++H D  L
Sbjct:    4 GDCNSAYHPDCIGL------STAPKGK----FKCDECTSGVHSCFVCRQTGD------VKACSQPLCSKFYHKECLQSYKCSKI----DGDRIYCPLHFCSTC-ISNKTPVNR-GRLTKCIRCPTAYHAG--CLVAGCMPITSHLM-------------------------------------------------VCAKHFLPNKSKAHHTHVNVNWCFVCSIGGTLICCESCPAAFHPECISYEGIPEGRFYCKDCVEGKSLLYGDIVWVKLGMYRWWPAMICNPRDVPTNIQSMRHQPGEFPVMFLGSHDFYWIHKGRVFSYQDGDKGTESGN----NKYLAKVFKKALVEAKEKYD-EWKKAREDKAEQDLQRFCK---------KPPQYKHIKTNKCTTAQRI--ILDPSEMPVCECTP----DQACGQDANCLNLMLQFECVASRCPAGDKCQNQRFQKRQYVDCEPFRAHSRGWGLRSKQAIKKGTFVIEYVGELIDDATCRERVKKGDDD--TNYYMLTIDKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQEELTFDYCLDCHGNEKKKCHCGSQNCSGFLGVRPKTQNAQMNEDKAKNAALKRRKRKPKKPAV----------------------KQVHEDDCFICGDGGQLIMCDRSGCLKCYHVDCLNLDKKPQGRWQCPWHFCDNCGKRATVLCSECPNSFCRSHAQGQINSTDKNTFLCTDHVDEVL 644          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO36934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH82])

HSP 1 Score: 218.394 bits (555), Expect = 1.053e-65
Identity = 95/135 (70.37%), Postives = 123/135 (91.11%), Query Frame = 1
Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSL++P+KF HILRV+NTNIDG++ I++A+T+I+GVGRR+A++VCKKA++D+NKRAGE+T+DE+E++ T+M NP  YKIP WFLNRQ+D KDG   QI+ANGLDNK+REDLERLKKI+ HRGLRH+WGLRVRGQH
Sbjct:    1 MSLVIPEKFQHILRVLNTNIDGKQKIMFAMTSIKGVGRRYANIVCKKADIDMNKRAGELTEDEVERVVTIMQNPRQYKIPDWFLNRQKDHKDGKYSQILANGLDNKMREDLERLKKIRAHRGLRHYWGLRVRGQH 135          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO43763 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXE9])

HSP 1 Score: 158.688 bits (400), Expect = 2.022e-42
Identity = 87/208 (41.83%), Postives = 115/208 (55.29%), Query Frame = 2
Query: 2168 RINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT 2791
            RINK         CEC P     D  G   +C+NR LM EC+   C  G+ C N+RF      K EVF T+ +GW ++TLE +++  FV EY GE+++  +   R ++       ++Y M L    IIDA    +ISRF+NHSC PN  TQKW+VNG  RIG F L TIKAGEELTF+Y     G+    C C + +C G +G    T
Sbjct:   19 RINKEVRKM---TCECYPEPDNPDFVGCGEDCLNRLLMIECNHR-CPCGDLCTNRRFQEGCKIKVEVFKTEKKGWGVKTLEDLEQNQFVIEYCGEVMNYRDFQSRAQRYDRQKRRHYYFMTLRADEIIDATLKGSISRFINHSCEPNCVTQKWTVNGLLRIGFFTLRTIKAGEELTFDYQLQRYGKIAQTCYCESPSCRGIIGGEKHT 222          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO44546 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVC2])

HSP 1 Score: 102.834 bits (255), Expect = 1.517e-24
Identity = 51/128 (39.84%), Postives = 72/128 (56.25%), Query Frame = 2
Query: 2390 WALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFL 2773
            W L  LEPI     V EYVGE+I +A A+ R +   E  + + YM  LD   IIDA    N +RF+NH C PN Y +  +V    +I +++   I+  EE+T++Y  F +  +K+PC CGA  C G L
Sbjct:   86 WGLFALEPIAADEMVIEYVGEVIRQAIADYRERCYEERGIGSSYMFRLDETTIIDATTMGNFARFINHCCDPNCYAKVIAVENMKKIVIYSKRDIQVDEEITYDYK-FPIEDEKIPCLCGAPQCRGTL 212          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO35277 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM02])

HSP 1 Score: 99.3673 bits (246), Expect = 1.007e-23
Identity = 66/197 (33.50%), Postives = 98/197 (49.75%), Query Frame = 2
Query: 2228 KCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQR---------IIDAGPAANISRFMNHSCSPNVYTQKWSVNG-DTR---IGLFALHTIKAGEELTFNYNF--FSLGQKKLPCKCGASNCSGFL 2773
            +CN  C  +S+C NR         V +NG   R Q           VF T +RGW LRTL+ +  G F+  Y G++++E  AN+  +   +  ++    +E    R         +IDA    N  R++NHSCSPN++ Q   ++  D R   +  FA H I AG ELT++Y +   S+  K+L C CG+S C G L
Sbjct:    3 ECNSNCACSSQCFNR---------VVQNGIQLRLQ-----------VFKTKSRGWGLRTLDDVPCGTFICTYSGQIMNEEMANKEGRDYGDEYLAELDHIERPTTRSLFGEEHCYVIDAKAYGNCGRYLNHSCSPNLFVQNVFIDTHDLRFPWVAFFAQHNIPAGSELTWDYMYEVGSVQDKELRCYCGSSECRGRL 179          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:101172132])

HSP 1 Score: 507.294 bits (1305), Expect = 3.985e-157
Identity = 294/809 (36.34%), Postives = 410/809 (50.68%), Query Frame = 2
Query:  893 KKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHV-RCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPD-SEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRL-VKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSIS 3310
            +K  +C +C    +++G +LV  C G C   FH  CL           P+ K  + L C  C   +  CF C++      + E+ +C   +CG++YH  C+       L  ++  G L CP H C +C+       K     + RCL CP ++H GD C+ AGS  I +  I+C  H +                K G    + VN                              V+WCF+C  GG+L+CCE CPA+ H  C  I      + C+DC++G+ PRY DI W+K+G+YRWWP +I HP N P  +    H  G+F V FFG+ DY+W ++   FP+ +GD  +   +  I     + +    +     K+ R+ +++ + +                   KP  Y+ IK N P G V++   AD++EIP+C C+P+D+   PCG  SEC+NR L YECHP VC +GE C NQ F +R YP+ ++  T  +GW L  L  IKKG FVNEY+GELIDE E   R+K AHE N++NFYM+ +D  RIIDAGP  N SRFMNHSC PN  TQKW+VNGDTR+GLFA+  I AG ELTFNYN   LG +K  C+CGA NCSGFLGD PK ++   +EP  K    + KK  +                           KK  + EC+RCG     + C  + C + YHL C++L+  P   W CPWH CD CG+ SE FC  C  S+C  H+   L  +     + C  H++L        E  NG  +   S+ G  +   +S
Sbjct:  573 RKEFVCQVC----EQAGEDLVP-CEGQCCGMFHLHCL----------GPSFKPEDKLLCQQCRAGIHSCFACKQ-----SEGEVRRCHVVHCGKFYHEACI---RLNPLTVFDNKG-LRCPLHACLSCHYGSRTKHKSTKGRLMRCLRCPVAYHVGDLCVAAGSEMITNTAIVCTNHFNA---------------KKGYSHHSHVN------------------------------VSWCFVCSKGGQLLCCESCPAAFHPDCLNIAMPDGSWYCNDCRAGKKPRYRDIIWVKLGTYRWWPAEIQHPRNIPTNIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGSKHQRTGIGRVFKNALLEAEARFKEMKMKREAKEAQESS------------------RKPPPYKFIKVNRPYGRVQVYT-ADVSEIPKCNCKPTDE--RPCGFESECLNRMLQYECHPQVCPSGERCCNQDFTKRLYPETKIIKTPGKGWGLVALRDIKKGKFVNEYIGELIDEEECRARIKYAHENNITNFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCHIPAGTELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNSNGHAAEPKGKRPKRKYKKRRSEG-------------------------KKKSEDECFRCGDGGQLVLCDKKTCTKAYHLSCLNLTKRPFGRWDCPWHHCDVCGKNSEAFCQLCPNSFCKAHQEGGLWPRPPGGELCCLEHDEL--------EGANGPAHDPGSVGGAAAPAPLS 1258          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 518.85 bits (1335), Expect = 5.515e-156
Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2
Query:  896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            K  +C +C    +++G  L+  C G C   FH  C+ L      +  P  K +    C +C   V  CF+C+K GE+     + +C    CG++YH  C+ N  +      NR     C  H+C  C+I +P +        VRC+ CP ++H  D C+ AGS  ++ N I+CP H +                                              P +  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P Y DI W+K+G YRWWP ++ HP   PE + +  H  G+F V FFG+NDY W  +   FP+ D D          ANS      ++  G G   +D  Y+K+L+ AA  +  R  + E  L     + KN  KP  Y+ IK N PIG V+I   ADL+E+P+C C+ +D+   PCG  SEC+NR L+YEC+P VC  GE C NQ F +R+Y + E+F T +RGW LR +  IKKG FV+EYVGE+IDE E   R++ A E ++ NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLFAL  +KAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK   P     DK   ++ +                          +     K  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +SYC  HR   L  S  +  + CS H+
Sbjct: 1281 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDE--SPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 1944          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 518.85 bits (1335), Expect = 5.482e-155
Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2
Query:  896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            K  +C +C    +++G  L+  C G C   FH  C+ L      +  P  K +    C +C   V  CF+C+K GE+     + +C    CG++YH  C+ N  +      NR     C  H+C  C+I +P +        VRC+ CP ++H  D C+ AGS  ++ N I+CP H +                                              P +  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P Y DI W+K+G YRWWP ++ HP   PE + +  H  G+F V FFG+NDY W  +   FP+ D D          ANS      ++  G G   +D  Y+K+L+ AA  +  R  + E  L     + KN  KP  Y+ IK N PIG V+I   ADL+E+P+C C+ +D+   PCG  SEC+NR L+YEC+P VC  GE C NQ F +R+Y + E+F T +RGW LR +  IKKG FV+EYVGE+IDE E   R++ A E ++ NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLFAL  +KAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK   P     DK   ++ +                          +     K  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +SYC  HR   L  S  +  + CS H+
Sbjct: 1687 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDES--PCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 2350          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 518.85 bits (1335), Expect = 5.482e-155
Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2
Query:  896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            K  +C +C    +++G  L+  C G C   FH  C+ L      +  P  K +    C +C   V  CF+C+K GE+     + +C    CG++YH  C+ N  +      NR     C  H+C  C+I +P +        VRC+ CP ++H  D C+ AGS  ++ N I+CP H +                                              P +  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P Y DI W+K+G YRWWP ++ HP   PE + +  H  G+F V FFG+NDY W  +   FP+ D D          ANS      ++  G G   +D  Y+K+L+ AA  +  R  + E  L     + KN  KP  Y+ IK N PIG V+I   ADL+E+P+C C+ +D+   PCG  SEC+NR L+YEC+P VC  GE C NQ F +R+Y + E+F T +RGW LR +  IKKG FV+EYVGE+IDE E   R++ A E ++ NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLFAL  +KAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK   P     DK   ++ +                          +     K  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +SYC  HR   L  S  +  + CS H+
Sbjct: 1687 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDES--PCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 2350          
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 518.079 bits (1333), Expect = 6.956e-155
Identity = 297/782 (37.98%), Postives = 406/782 (51.92%), Query Frame = 2
Query:  896 KNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNH-VRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSH-NVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESIL-----NLKN--KPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSS-NENMVCSNHE 3211
            K  +C +C    +++G  L+  C G C   FH  C+ L      +  P  K +    C +C   V  CF+C+K GE+     + +C    CG++YH  C+ N  +      NR     C  H+C  C+I +P +        VRC+ CP ++H  D C+ AGS  ++ N I+CP H +                                              P +  K+  H NV+WCF+C +GG L+CCE CPA+ H+ C  I+     + C+DC++G+ P Y DI W+K+G YRWWP ++ HP   PE + +  H  G+F V FFG+NDY W  +   FP+ D D          ANS      ++  G G   +D  Y+K+L+ AA  +  R  + E  L     + KN  KP  Y+ IK N PIG V+I   ADL+E+P+C C+ +D+   PCG  SEC+NR L+YEC+P VC  GE C NQ F +R+Y + E+F T +RGW LR +  IKKG FV+EYVGE+IDE E   R++ A E ++ NFYM+ LD  RIIDAGP  N +RFMNH C PN  TQKW+VNGDTR+GLFAL  +KAG ELTFNYN   LG  K  CKCGA NCSGFLG  PK   P     DK   ++ +                          +     K  + EC+ CG     + C    CP+VYH  C++L+  P   W CPWH CD CG+ +  FC  C +SYC  HR   L  S  +  + CS H+
Sbjct: 1604 KETICQVC----EKTGELLL--CEGQCCGAFHLACISL------ADAPKGKFV----CPECKSGVHTCFVCKKRGED-----VRRCMIPVCGKFYHGECITN--HAPTAPVNRG--FRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFT----------------------------------------------PRRGVKNHEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVD----------ANS------KEKMGKG---VDTTYKKALEEAA--VRFRELQAEKELRQLQEDRKNDRKPPPYKHIKVNRPIGKVQIFT-ADLSEVPRCNCKATDES--PCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNNPPS---DDKGRKMKRRGHGRRK--------------------KKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHD 2267          
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1)

HSP 1 Score: 1700.26 bits (4402), Expect = 0.000e+0
Identity = 833/836 (99.64%), Postives = 835/836 (99.88%), Query Frame = 2
Query:  806 ALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 3313
            ALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLG+NDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGS+EINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKI INKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI
Sbjct:  296 ALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKILINKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 1131          
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1)

HSP 1 Score: 1669.83 bits (4323), Expect = 0.000e+0
Identity = 818/825 (99.15%), Postives = 821/825 (99.52%), Query Frame = 2
Query:  839 IVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 3313
            +   FEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLG+NDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGS+EINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKI INKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI
Sbjct:  292 VAETFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELKKSYNSNNKIDKKKILINKKPNNTVDLQNFFQKKLVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPTESQNGSINATLSITGTDSLPSISI 1116          
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000015015.1 (SMESG000015015.1)

HSP 1 Score: 492.271 bits (1266), Expect = 1.132e-155
Identity = 290/791 (36.66%), Postives = 409/791 (51.71%), Query Frame = 2
Query:  845 LNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPEAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHL-SMGGSAEITVTPFMDCIKNG---RVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKALVLRTSKWES-----ILNLKNKPSQYRSIKTN-VPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKTASPDSEPSDKDSILELXXXXXXXXXXXXXXXXXXXXXXXTVDLQNFFQKKLVDQECYRCGQ---NNCEIFCSHQHCPRVYHLQCVSL--SNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYC---LLHRFN 3163
            + + F  L LP  S    N  C  CLE  +      +  C       FH  CL  L + +      TK+ +  +C++C+  + RC+ C K+ +   +   M+C    C +++H+NCL  G   ++  + + G L CP HICH C + +P    +C+  + C+MCP++FH GDWCIPAGS E+N   IICP+HL  +  S  I V PF+  +K+    R+  N+    LT  ++P       + KP         NV WCF C +GG+L+CCE CPA+ H  C  + EIP  F C DC S  Y  YG+I W+K G++ WWPGQI+H  N P+ +    H +GQF+VQFFG+ DY W +  + F +E  D+   +  K   N              N  L+R     +K AA   V R  KW+S     ++N K     Y  I+ N  P+   R   P    E P C C   D  +D C   S C N     EC P +C  G+ C+NQ F++R YPKQ  F  ++RGW L+  E IK   FVNEY+GE+I   E+ +R+  A+E N+S+FY MELD  R+IDA   +N+SRF+N+SC PN+  +KW VN + RIGLFAL  I+ GEELTF YN  +    ++ CKC + NCSGFLG+ PK A      SD                      S      +    ++F   K  + +C+RCG+       I CS   C + YH  C++L  +N  +S W+CP H CD C R S +F S  T SYC    + +FN
Sbjct:  178 IKYAFDELTLPFVSVKLTNKNCRYCLETKN------IVQCNKCLFNNFHVKCLEFLQNSIE-----TKINDLDRCLECSLGIIRCYACYKIVDISNEQGFMRCIIKTCTKWFHTNCLETGPMLEMTKFPKPGQLVCPCHICHKCELVNPSPKYRCTKLIVCIMCPATFHTGDWCIPAGSVELNTGEIICPRHLVDLNFSMNIMVPPFVARVKSDLQERIYGNT----LTKISEPMTITPSTVTKPT--------NVNWCFKCGEGGELLCCETCPAAYHFKCTDLKEIPQKFYCPDCASFCYRSYGEIVWIKCGTHPWWPGQILHLENVPKNIAAKKHANGQFVVQFFGSRDYMWRDHGNVFLYEKEDECNSKTSKYRYN--------------NIFLER-----IKEAAIGYVTREEKWQSGSCDHVMNSK----IYNKIQVNKCPLELRRKVVP----ETPHCNCISFDPKSD-CSIGSGCFNVASKCECDPQICNLGDKCKNQNFVKRIYPKQYTFWANDRGWGLKADEFIKTKQFVNEYIGEIITMEESEKRILWANENNISDFYFMELDNGRLIDARQFSNLSRFINNSCDPNLVAEKWIVNREHRIGLFALRDIQKGEELTFQYNLQNKSSNRIVCKCFSVNCSGFLGEAPKMAKVSKLKSDTSK------------------KSKGDTTESESSCKSFLTDKNSNSQCFRCGEIIDMLSSIVCSVGPCMKTYHSVCLNLNMANYVQSSWICPHHYCDVCARPSHHFSSNTTESYCNKDFIKKFN 899          
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000081033.1 (SMESG000081033.1)

HSP 1 Score: 388.267 bits (996), Expect = 6.260e-117
Identity = 264/842 (31.35%), Postives = 392/842 (46.56%), Query Frame = 2
Query:  944 NNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGENDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPE-AVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKA-----------LVLRTSKWESI--------LNLK---NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLP-CKCGASNCSGFLGDPPKTASPD----SEPSDKDSILELXX---XXXXXXXXXXXXXXXXXXXXXTVDL------------------QNFFQKKLVDQE------------CYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMV---CSNHEDLFLSHGSPTESQNGSINATLS 3277
            NN V  CTG C + FH  CL+     L   +PT+K     +C+DC   +  C +CQK+   DK D+++ C  S+CGR YH +CL   ++   I  + +  L+CPSH C +C  +D   A   C   V CL CP SFH  D C+ AG+ E++ +++ICP+H                  +N  VKLN+                            K  +  WCF C   G  + C  CPAS H  C +       ++C +C++ R PRYG++ ++K+  YRWWP +IIHP NAP  +LK +  DG + V F G+N+Y W+ KT +  F      T +   I   S            G T++DRD+   L++A K            + LR+    S+        +N+K    K  +++ IK N+      I  PA L   P+ +    D C D C P  +C N     EC    C     C+NQ+F   ++    VF T NRG+ L+T  PI K  F+ EY+GELI + E+  R+  A + N  +FYM+ L G  +IDAGP  N+SR+MNHSC PN Y + W VNG  + G+FAL  I + +ELTF+Y    +  K+   C C ++NC+GFLG  P  + P+    S+ + ++S + L          +         +   +  +DL                   N  ++K +  +            CYRC      + C   +CP+ YHL C+ L   P   W CPWH CD CG+ S+ FC  C  S+C  H       +   N++       + + L H SP E+Q   ++   S
Sbjct:  155 NNAVLQCTGICKRYFHLHCLK----NLKENQPTSKP--NFQCLDCFSGIYHCILCQKV---DKIDDLLACENSDCGRLYHKSCLEMSNFIG-IEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHF-----------------ENKLVKLNA---------------------------HKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFN-----TAQFSSIFKESG-----------GTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANI------IVPPAKLP--PKVQASICD-CVDNC-PKQDCKNYLNKIECQITQC---PKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG--PIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLITEAPILDESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH-------AQETNIIIPTIKTRKSICLLHKSPPENQTSYLHDEAS 904          
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039926.1 (SMESG000039926.1)

HSP 1 Score: 280.796 bits (717), Expect = 1.688e-87
Identity = 135/135 (100.00%), Postives = 135/135 (100.00%), Query Frame = 1
Query: 3472 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 3876
            MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH
Sbjct:    1 MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEVDVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMANGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQH 135          
The following BLAST results are available for this feature:
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NSD39.267e-15737.56nuclear receptor binding SET domain protein 3 [Sou... [more]
NSD35.253e-15637.61nuclear receptor binding SET domain protein 3 [Sou... [more]
NSD11.686e-15439.23nuclear receptor binding SET domain protein 1 [Sou... [more]
NSD11.686e-15439.23nuclear receptor binding SET domain protein 1 [Sou... [more]
NSD12.758e-15439.23nuclear receptor binding SET domain protein 1 [Sou... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rps-181.061e-6371.11Ribosomal Protein, Small subunit [Source:UniProtK... [more]
met-12.296e-3139.44Histone-lysine N-methyltransferase [Source:UniPro... [more]
met-12.577e-3139.44Histone-lysine N-methyltransferase [Source:UniPro... [more]
set-121.685e-2837.63Histone-lysine N-methyltransferase [Source:UniPro... [more]
set-24.882e-2235.66Histone-lysine N-methyltransferase set-2 [Source:... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NSD4.230e-10231.59gene:FBgn0039559 transcript:FBtr0335014[more]
NSD4.433e-10231.59gene:FBgn0039559 transcript:FBtr0085267[more]
RpS184.155e-5863.70gene:FBgn0010411 transcript:FBtr0086274[more]
RpS184.155e-5863.70gene:FBgn0010411 transcript:FBtr0086273[more]
Set28.540e-4041.54gene:FBgn0030486 transcript:FBtr0073779[more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd1b1.448e-16338.37nuclear receptor binding SET domain protein 1b [So... [more]
nsd1b4.453e-16138.37nuclear receptor binding SET domain protein 1b [So... [more]
nsd1a4.958e-15438.39nuclear receptor binding SET domain protein 1a [So... [more]
nsd1a5.603e-15438.39nuclear receptor binding SET domain protein 1a [So... [more]
nsd36.397e-15237.37nuclear receptor binding SET domain protein 3 [Sou... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NSD14.851e-15637.50nuclear receptor binding SET domain protein 1 [Sou... [more]
NSD21.033e-15536.24nuclear receptor binding SET domain protein 2 [Sou... [more]
NSD21.216e-15536.27nuclear receptor binding SET domain protein 2 [Sou... [more]
NSD32.006e-15537.68Triosephosphate isomerase [Source:UniProtKB/Swiss... [more]
NSD24.092e-15536.27nuclear receptor binding SET domain protein 2 [Sou... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nsd22.628e-15636.46nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd22.628e-15636.46nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd23.005e-15636.46nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd31.207e-15537.48nuclear receptor binding SET domain protein 3 [Sou... [more]
Nsd11.286e-15539.50nuclear receptor-binding SET-domain protein 1 [Sou... [more]
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BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8BVE8|NSD2_MOUSE2.102e-15536.46Histone-lysine N-methyltransferase NSD2 OS=Mus mus... [more]
sp|Q9BZ95|NSD3_HUMAN2.522e-15537.61Histone-lysine N-methyltransferase NSD3 OS=Homo sa... [more]
sp|O88491|NSD1_MOUSE3.899e-15539.37Histone-lysine N-methyltransferase, H3 lysine-36 s... [more]
sp|Q96L73|NSD1_HUMAN1.325e-15339.23Histone-lysine N-methyltransferase, H3 lysine-36 s... [more]
sp|O96028|NSD2_HUMAN3.256e-15336.70Histone-lysine N-methyltransferase NSD2 OS=Homo sa... [more]
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BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267ERM70.000e+039.63Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A1I8IAL60.000e+039.63Histone-lysine N-methyltransferase OS=Macrostomum ... [more]
A0A267FZR20.000e+039.63Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A1I8H0A00.000e+039.02Histone-lysine N-methyltransferase OS=Macrostomum ... [more]
A0A2T7PCE14.914e-17339.63Uncharacterized protein OS=Pomacea canaliculata OX... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd1a1.493e-15639.03nuclear receptor binding SET domain protein 1a [So... [more]
nsd1b1.105e-15540.63nuclear receptor binding SET domain protein 1b [So... [more]
nsd21.597e-15536.96nuclear receptor binding SET domain protein 2 [Sou... [more]
nsd25.107e-15536.84nuclear receptor binding SET domain protein 2 [Sou... [more]
nsd37.036e-12240.11nuclear receptor binding SET domain protein 3 [Sou... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd24.371e-15335.57nuclear receptor binding SET domain protein 2 [Sou... [more]
ENSPMAT00000003690.18.373e-4340.00pep scaffold:Pmarinus_7.0:GL484755:705:3732:1 gene... [more]
ENSPMAT00000005461.12.052e-3139.23pep scaffold:Pmarinus_7.0:GL477205:1717:42601:-1 g... [more]
SUV39H22.891e-2436.73suppressor of variegation 3-9 homolog 2 [Source:HG... [more]
setd1a2.097e-2235.57SET domain containing 1A, histone lysine methyltra... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
RPS18B9.127e-5763.50Protein component of the small (40S) ribosomal sub... [more]
RPS18A9.127e-5763.50Protein component of the small (40S) ribosomal sub... [more]
SET23.800e-3836.09Histone methyltransferase with a role in transcrip... [more]
SET19.884e-2239.23Histone methyltransferase, subunit of the COMPASS ... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO431561.602e-13134.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO369341.053e-6570.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO437632.022e-4241.83Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO445461.517e-2439.84Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO352771.007e-2333.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd23.985e-15736.34nuclear receptor binding SET domain protein 2 [Sou... [more]
nsd1b5.515e-15637.98histone-lysine N-methyltransferase, H3 lysine-36 a... [more]
nsd1b5.482e-15537.98histone-lysine N-methyltransferase, H3 lysine-36 a... [more]
nsd1b5.482e-15537.98histone-lysine N-methyltransferase, H3 lysine-36 a... [more]
nsd1b6.956e-15537.98histone-lysine N-methyltransferase, H3 lysine-36 a... [more]
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BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000039925.10.000e+099.64SMESG000039925.1[more]
SMESG000039925.10.000e+099.15SMESG000039925.1[more]
SMESG000015015.11.132e-15536.66SMESG000015015.1[more]
SMESG000081033.16.260e-11731.35SMESG000081033.1[more]
SMESG000039926.11.688e-87100.00SMESG000039926.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002598 ID=SMED30002598|Name=Histone-lysine N-methyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=3973bp
AGTTTATCTTAAATTTTATGCGATCAAATTCAAATAGTTTATTACAGATA
ATAATCGAAATAAGTATAAAATGATAAATTATTTCTCTTATATTTAGAAT
ATATCTCGTAAATGGTTAATAATGTGTAATTAATGGGCAAAATGCTATTG
GTAATATTCAGTGGTCTAATTGAAGGTAATCGCCGAGGATCCTTAACCAT
TAGTGTTGTAAAATTCTACTTTAAATGTCACCAGATTTCGTATAAAAAGT
AATTATATGTTCGCGGAAAATTCCAATTGTAATTTAAATGAGGCTTCTAA
CTCAGTGCCAGTTTCGAGTTCCTTTCTAAAAGGATTTAAAATATTTATTT
TTACAAAAAATACAGCTTGTCGAGTCTAGCTTTTCATATCTCATTCTAAA
ACTGGTTAAATCCGCGAGAAAAAAGATATTGAGTCAAGGTCGAAATTTCC
AACGTCATTTTAACTCGTATTTCAGATTAGAAATGGTTCATCTGAATTGC
ATATTTATGTTATTTTTATTGATATCTATAACATTGATAACATATTGACA
AATATCCAATTATTAAGGGGGCCCATGACGATTGTTTTTGTACAAGGCAC
AAAATCAATTTTTTTTAAACTAGCAGCTTTGTTTAATAAATTATCACGGC
TCAGTCGATAATATTTTTGCAGTAGATGAGGATTTTATATGGAATTGCCT
ATTAATACTAAATTTTAGTCGCTGTTTTCACTACTCTTTAAAGAGAAATT
ATCATTTTGGTTATATTCTGAAGTTCTAATTATGAAAACAAGTGGTTAAA
CGGAGGCGTTAACAATTGTGTATATCGGGAGGTTTTCAATTGTGTTAAAC
TTTGAATTCCAAAATTTAAAGTTGCCAACATTTTCAAATTGCAAAAAAAA
TCCACTTTGTTTTCTGTGTTTAGAAGAAAACGATGAATCGGGTAATAATT
TAGTCGCCAATTGTACCGGAGGCTGTGGCCAACAGTTCCATCCGGATTGT
CTTAGGTTGTTATTTGATTATCTCACATCGAAAGAACCGACAACGAAAGT
GATAAATTACTTAAAATGTGTTGATTGCAACAGGAATGTTCGTCGATGTT
TCATTTGTCAAAAGTTGGGGGAAAATGACAAAAAAGATGAAATGATGAAA
TGTTCCACTTCTAATTGTGGACGCTATTATCACTCGAATTGCTTGTATAA
TGGACATTATCAGCAACTGATCACTTATAATAGAAGCGGTTCGTTGACAT
GTCCATCTCATATCTGTCACGCGTGCTATATTGATGATCCTGAAGCCGTG
AAACAATGCTCCAATCATGTGCGATGTTTAATGTGTCCTTCGTCATTTCA
CAAAGGCGATTGGTGCATTCCAGCAGGATCGAGAGAGATCAACGACAACT
ACATAATTTGTCCCAAACATCTATCGATGGGAGGTTCTGCCGAAATTACT
GTTACTCCTTTCATGGATTGCATTAAAAATGGACGTGTGAAATTGAATTC
CGTCAATTTTAAACTCACACCTTTTAATGATCCTCAAAATAAAGATTTCT
GGGTTTTGGAAAAGCCTCTTAAAGTTTCCAAATCTAAGTCTCACAATGTT
ACCTGGTGCTTTCTTTGTCCAGATGGTGGTAAATTGATTTGCTGTGAAAG
ATGTCCGGCTTCTCTTCATCAGCACTGTGCGGCTATTGACGAGATTCCTG
TTGTGTTCATTTGTGATGATTGTCAGTCTGGTAGATATCCGCGGTACGGT
GATATCTATTGGCTAAAAATAGGCTCATATCGATGGTGGCCGGGTCAAAT
CATTCACCCAAATAATGCACCTGAGAAAGTTCTCAAAGCTTCACATGGAG
ATGGACAGTTTCTCGTACAATTCTTTGGCACCAATGATTACTATTGGATG
AACAAAACCCATGCTTTCCCATTTGAAGACGGGGACGATAAGACTGGAGA
AATGAAAAAGATTATTGCCAACAGCTCTTTGGATGAGGTGACTCGTGATA
CATCTGGAAACGGGAATACTAAGCTTGATCGAGACTACAGGAAGAGTTTG
AAAATTGCAGCAAAAGCTCTCGTATTACGAACAAGTAAATGGGAATCGAT
TCTTAATTTAAAGAACAAACCCAGTCAATATCGATCGATAAAGACCAATG
TTCCGATCGGTAATGTGAGAATCAATAAACCAGCTGATCTAACGGAAATA
CCACAGTGTGAATGCCGACCCAGTGATAAGTGCAATGATCCATGTGGCCC
TACTAGTGAATGCATGAATCGAGAACTCATGTATGAATGTCATCCTCTCG
TATGTCGTAATGGAGAAAACTGTCGTAATCAGCGATTTATGAGAAGGGAA
TATCCAAAACAGGAAGTATTCTCAACTGATAATCGTGGTTGGGCTTTGAG
AACGTTGGAACCCATTAAAAAGGGCGCATTTGTTAATGAATATGTTGGAG
AGTTAATAGATGAAGCAGAAGCCAATAGAAGATTAAAGAAAGCCCATGAG
ACAAATGTTTCAAACTTCTATATGATGGAATTAGATGGACAGAGAATAAT
CGATGCCGGTCCCGCCGCAAATATTAGCCGTTTCATGAATCACTCTTGTT
CTCCTAATGTATATACTCAAAAATGGTCAGTCAACGGTGATACTAGAATC
GGACTGTTTGCTCTTCATACTATTAAAGCTGGTGAAGAATTAACTTTCAA
CTATAACTTCTTTTCTCTTGGTCAAAAAAAGCTCCCGTGTAAATGTGGTG
CTAGTAACTGCTCTGGATTTCTAGGTGATCCCCCAAAAACAGCATCTCCT
GATTCTGAGCCATCGGATAAAGATTCTATTTTAGAATTGAAAAAATCATA
TAATTCTAATAACAAAATCGATAAAAAGAAAATTTCAATTAATAAAAAGC
CAAATAACACAGTCGACTTGCAAAATTTTTTCCAAAAGAAATTAGTTGAT
CAAGAATGTTACAGGTGCGGGCAGAATAATTGTGAAATATTTTGTTCACA
TCAACACTGTCCTAGAGTCTATCATTTGCAATGTGTCAGCTTAAGCAACA
TACCAAAGAGCTTATGGTTGTGTCCCTGGCATTGTTGTGATGACTGTGGT
AGAATTTCTGAATATTTTTGTTCTGAATGTACTACATCATATTGCTTATT
ACATCGTTTTAATCGATTAGTCAAAAGTTCAAATGAAAACATGGTTTGTT
CTAATCATGAAGATTTATTTTTATCACATGGTAGTCCTACAGAATCTCAA
AATGGCAGCATTAATGCAACTTTATCTATCACTGGAACAGATTCTTTGCC
AAGCATTTCTATTTAATAAAAGATTTTTATTTAAATTTTTTTAAGTTTTA
CGATTTTAAATTTAAATTTAAAAGTTTATTTGAAAAATTACAATTGAAAT
AAATTATTAAATTGTTTAAATATTATATTTGTTATAGTTAAAAGTAATTT
AAACATAGATATTTTTGTACAATGTCTTTGATAATGCCCCAGAAGTTTAA
TCACATTCTCCGTGTGATGAATACTAACATTGATGGAGAAAGAACTATTG
TATATGCATTAACTGCCATCAGAGGTGTTGGAAGACGTTTCGCTCACGTT
GTCTGTAAGAAAGCAGAAGTTGATGTTAACAAAAGAGCTGGTGAAATAAC
AGATGATGAATTAGAAAAAATTACAACTGTTATGGCTAATCCAACTGTAT
ACAAAATCCCTAAGTGGTTCCTTAATAGACAAAGAGATATTAAAGATGGT
GCAAACTTACAAATTATGGCTAATGGTTTGGATAATAAGCTTCGTGAAGA
TTTGGAACGATTAAAGAAAATCAAATGTCACAGAGGTCTTAGACACCATT
GGGGATTGAGAGTTCGTGGTCAACATACAAAGACTACCGGAAGACGTGGA
AGAACTGTTGGAGTTTCAAAGAAGAAGGGAGCATAAGATGTAATTAAATA
AATTTTGGATACTAGAAAAAAAA
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protein sequence of SMED30002598-orf-1

>SMED30002598-orf-1 ID=SMED30002598-orf-1|Name=SMED30002598-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=155bp
MSLIMPQKFNHILRVMNTNIDGERTIVYALTAIRGVGRRFAHVVCKKAEV
DVNKRAGEITDDELEKITTVMANPTVYKIPKWFLNRQRDIKDGANLQIMA
NGLDNKLREDLERLKKIKCHRGLRHHWGLRVRGQHTKTTGRRGRTVGVSK
KKGA*
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protein sequence of SMED30002598-orf-2

>SMED30002598-orf-2 ID=SMED30002598-orf-2|Name=SMED30002598-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=725bp
MMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDP
EAVKQCSNHVRCLMCPSSFHKGDWCIPAGSREINDNYIICPKHLSMGGSA
EITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKS
HNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYP
RYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDY
YWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYR
KSLKIAAKALVLRTSKWESILNLKNKPSQYRSIKTNVPIGNVRINKPADL
TEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFM
RREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKK
AHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGD
TRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGASNCSGFLGDPPKT
ASPDSEPSDKDSILELKKSYNSNNKIDKKKISINKKPNNTVDLQNFFQKK
LVDQECYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCD
DCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMVCSNHEDLFLSHGSPT
ESQNGSINATLSITGTDSLPSISI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0018024histone-lysine N-methyltransferase activity
GO:0003735structural constituent of ribosome
GO:0003723RNA binding
GO:0003676nucleic acid binding
GO:0008168methyltransferase activity
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000028Category 2 cell
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0000240body wall musculature
PLANA:0000429neoblast
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR041306C5HCH
IPR001965Znf_PHD
IPR001214SET_dom
IPR006560AWS_dom
IPR003616Post-SET_dom
IPR000313PWWP_dom
IPR013083Znf_RING/FYVE/PHD
IPR019786Zinc_finger_PHD-type_CS
IPR011011Znf_FYVE_PHD
IPR001892Ribosomal_S13
IPR02743730s_Rbsml_prot_S13_C
IPR018269Ribosomal_S13_CS
IPR010979Ribosomal_S13-like_H2TH
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005622intracellular
GO:0005840ribosome
GO:0005654nucleoplasm
GO:0005694chromosome
Vocabulary: biological process
TermDefinition
GO:0006412translation
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0016569covalent chromatin modification
GO:0016571histone methylation
GO:0032259methylation
GO:0034968histone lysine methylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001965Zinc finger, PHD-typeSMARTSM00249PHD_3coord: 605..648
e-value: 1.3E-4
score: 31.4
coord: 155..195
e-value: 5.0E-4
score: 29.4
IPR000313PWWP domainSMARTSM00293PWWP_4coord: 200..262
e-value: 6.3E-13
score: 58.9
IPR000313PWWP domainPFAMPF00855PWWPcoord: 201..272
e-value: 4.2E-18
score: 65.5
IPR000313PWWP domainPROSITEPS50812PWWPcoord: 202..264
score: 17.35
IPR003616Post-SET domainSMARTSM00508PostSET_3coord: 529..545
e-value: 1.0E-4
score: 31.7
IPR003616Post-SET domainPROSITEPS50868POST_SETcoord: 529..545
score: 10.543
IPR006560AWS domainSMARTSM00570shorttest3coord: 351..404
e-value: 4.3E-15
score: 66.1
IPR006560AWS domainPFAMPF17907AWScoord: 366..402
e-value: 8.8E-11
score: 41.7
IPR006560AWS domainPROSITEPS51215AWScoord: 351..403
score: 14.348
IPR001214SET domainSMARTSM00317set_7coord: 405..528
e-value: 1.9E-41
score: 153.7
IPR001214SET domainPFAMPF00856SETcoord: 416..522
e-value: 1.4E-18
score: 67.9
IPR001214SET domainPROSITEPS50280SETcoord: 405..522
score: 19.044
IPR041306NSD, Cys-His rich domainPFAMPF17982C5HCHcoord: 646..690
e-value: 2.9E-6
score: 27.3
NoneNo IPR availableGENE3DG3DSA:2.170.270.10coord: 298..563
e-value: 4.5E-83
score: 280.9
NoneNo IPR availableGENE3DG3DSA:2.30.30.140coord: 200..293
e-value: 4.2E-19
score: 70.5
NoneNo IPR availablePANTHERPTHR22884SET DOMAIN PROTEINScoord: 152..672
coord: 4..95
NoneNo IPR availablePANTHERPTHR22884:SF312HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 AND H4 LYSINE-20 SPECIFICcoord: 152..672
NoneNo IPR availablePANTHERPTHR22884:SF312HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 AND H4 LYSINE-20 SPECIFICcoord: 4..95
NoneNo IPR availableCDDcd15566PHD3_NSDcoord: 42..93
e-value: 8.3596E-11
score: 55.513
NoneNo IPR availableSUPERFAMILYSSF82199SET domaincoord: 325..535
NoneNo IPR availableSUPERFAMILYSSF63748Tudor/PWWP/MBTcoord: 192..317
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 148..199
e-value: 2.1E-8
score: 35.7
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 594..693
e-value: 3.8E-19
score: 70.7
IPR019786Zinc finger, PHD-type, conserved sitePROSITEPS01359ZF_PHD_1coord: 156..194
IPR019786Zinc finger, PHD-type, conserved sitePROSITEPS01359ZF_PHD_1coord: 606..663
IPR011011Zinc finger, FYVE/PHD-typeSUPERFAMILYSSF57903FYVE/PHD zinc fingercoord: 145..207
IPR011011Zinc finger, FYVE/PHD-typeSUPERFAMILYSSF57903FYVE/PHD zinc fingercoord: 603..647