Urocanate hydratase

Overview
NameUrocanate hydratase
Smed IDSMED30002510
Length (bp)2234
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Urocanate hydratase (SMED30002510) t-SNE clustered cells

Violin plots show distribution of expression levels for Urocanate hydratase (SMED30002510) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Urocanate hydratase (SMED30002510) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Urocanate hydratase (SMED30002510) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30002510

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30002510h1SMcG0001430 Contig20455uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002510h1SMcG0001430 Contig20455newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30002510h1SMcG0001430 dd_Smed_v4_1655_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30002510h1SMcG0001430 dd_Smed_v4_1655_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002510h1SMcG0001430 Contig54269uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002510h1SMcG0001430 Contig54269newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
tail regionSMED30002510h1SMcG0001430 dd_Smed_v6_1655_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Urocanate hydratase vs. Ensembl Human
Match: UROC1 (urocanate hydratase 1 [Source:HGNC Symbol;Acc:HGNC:26444])

HSP 1 Score: 810.831 bits (2093), Expect = 0.000e+0
Identity = 390/666 (58.56%), Postives = 492/666 (73.87%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRN----QKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETA 2095
            L  L  G+PL PLPEN G  +  PHA V    L+  +K+L+++NAL+YFP ++ E L  EF  EL+ YGHIYMYRF P  E +RAY I+ YP +   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+ M +LS+M  +QTLVMYSGHPLGLFP++   ++P++VI+NGMV+PNYSS  +YEKLFALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R     +  +G         KVFVTSGLGGMSGAQAKA+VI  CIGVIAEV K AL+KR  QGW+ ++ +S+   I+++R+  K  +  S+G +GNVV LWE LV    +TGE L D+GSDQTSCH    GGYYP  LS+ +++ LM  +   FK LV ESLR+QV+AIN L+ +  +F+DYGNAFLL+A R+GADV            + +F+YPSYVQ IMG IFS GFGPFRW+C+S D +DL  TDE+A   +E+ +++           K++VKLQY DN+ WI+ A  + LVVGS+ARILY+D +GRV IA A N+AIA + + AP++LSRDHHDVSGTDSPFRETSNIYDGSA CADMA+QN +GD+ RGATWVA+HNGGG GWGE INGGFGL+LDG+ EA  ++  ML WDV NG++RR WSGN+ A
Sbjct:    4 LQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIE-MRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSS--RSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAG---------KVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADV------EKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIAD---------GVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKA 642
[Close]
BLAST of Urocanate hydratase vs. Ensembl Human
Match: UROC1 (urocanate hydratase 1 [Source:HGNC Symbol;Acc:HGNC:26444])

HSP 1 Score: 431.409 bits (1108), Expect = 2.785e-140
Identity = 205/357 (57.42%), Postives = 260/357 (72.83%), Query Frame = 2 
Query: 1025 RDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETA 2095
            R+  K  +  S+G +GNVV LWE LV    +TGE L D+GSDQTSCH    GGYYP  LS+ +++ LM  +   FK LV ESLR+QV+AIN L+ +  +F+DYGNAFLL+A R+GADV            + +F+YPSYVQ IMG IFS GFGPFRW+C+S D +DL  TDE+A   +E+ +++           K++VKLQY DN+ WI+ A  + LVVGS+ARILY+D +GRV IA A N+AIA + + AP++LSRDHHDVSGTDSPFRETSNIYDGSA CADMA+QN +GD+ RGATWVA+HNGGG GWGE INGGFGL+LDG+ EA  ++  ML WDV NG++RR WSGN+ A
Sbjct:  361 REARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADV------EKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIAD---------GVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKA 702

HSP 2 Score: 386.726 bits (992), Expect = 3.399e-123
Identity = 186/310 (60.00%), Postives = 233/310 (75.16%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRN----QKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIR 1027
            L  L  G+PL PLPEN G  +  PHA V    L+  +K+L+++NAL+YFP ++ E L  EF  EL+ YGHIYMYRF P  E +RAY I+ YP +   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+ M +LS+M  +QTLVMYSGHPLGLFP++   ++P++VI+NGMV+PNYSS  +YEKLFALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R     +  +G         KVFVTSGLGGMSGAQAKA+VI  CIGVIAEV K AL+KR  QGW+ ++ +S+   I+++R
Sbjct:    4 LQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIE-MRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSS--RSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAG---------KVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLR 301
[Close]
BLAST of Urocanate hydratase vs. Ensembl Celegans
Match: Y51H4A.7 (Probable urocanate hydratase [Source:UniProtKB/Swiss-Prot;Acc:Q9NAE2])

HSP 1 Score: 723.776 bits (1867), Expect = 0.000e+0
Identity = 365/684 (53.36%), Postives = 475/684 (69.44%), Query Frame = 2 
Query:  110 LNILSLGI-PLVPLPEN--NGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYP 2152
            +NI SL + P  PL E+     + +  HA      LT ++K L+V+NAL+Y PK  H  L  EF  EL TYGHIY YRF P  ++  A  +    A   +A+AI+LMI NNLD  +AQ+P+ELVTYGGNGQVFSNW Q+ +V+++L  M   QTLV+YSGHPLGLFP+ P  +SP+M ++NGM++P+YS+   Y+K FALGV+QYGQMTAGS+CYIGPQGIVHGT++T++NA R           S   KVFVT+GLGGMSGAQ KA+ IA CIGVIAE+S TAL KR  QGW++  +  + E++  I+++ +  +  SIG  GNVVDLWE L +      E L ++GSDQTS H    GG+YPAGL++E+S  +M  D  KFK LV  SL +Q+ AI+ ++ KGMYF+DYGNAFLL+  R+GA++  ++   + S     F+YPSY+QDIMG IFSMGFGPFRW+C+S   +DL  TD+ A K I+++         KD      VK QY DN  WI+ A+   LVVGS+ARILY+D  GRV +A AFNE + +  VSA I++SRDHHDVSGTDSPFRETSN+YDGSA  ADMA+QN IGDSFRGATWVA+HNGGG GWG+ INGGFG++LDGS +A  ++  ML WDV NG++RR WSGN  A+  ++R   +   L +  P
Sbjct:    1 MNIPSLFVDPFSPLLEHPTEQRAKNVAHAPKRPCNLTQTEKMLAVRNALRYIPKEHHVLLATEFAEELNTYGHIYGYRFMPNFDLF-APPVSEIGAHCEQASAIILMILNNLDKRVAQFPQELVTYGGNGQVFSNWIQFRLVLRYLYTMTDHQTLVLYSGHPLGLFPSTP--DSPRMTVTNGMMIPSYSTKELYDKYFALGVTQYGQMTAGSFCYIGPQGIVHGTTITVLNAGRRMGLD------SLAGKVFVTAGLGGMSGAQPKAAKIAGCIGVIAEISDTALLKRHQQGWLDVYSKDLEEIVNWIKEYREKKEAISIGYLGNVVDLWERLAEEP----ECLVELGSDQTSLHNPFLGGFYPAGLTFEQSNQMMTSDPVKFKKLVQNSLIRQIAAIDKIAAKGMYFWDYGNAFLLECQRAGANLLREDAQDDKS-----FRYPSYMQDIMGDIFSMGFGPFRWVCTSGKPEDLRLTDQTACKIIDEL---------KDTDVPEYVKQQYLDNKKWIEEAEKNKLVVGSQARILYSDRAGRVALASAFNELVKSGKVSAAIVISRDHHDVSGTDSPFRETSNVYDGSAFTADMAVQNCIGDSFRGATWVALHNGGGVGWGDVINGGFGIVLDGSSDAARRAEGMLNWDVPNGVTRRSWSGNAKAQEAIQRAEKQVDGLRVTLP 657
[Close]
BLAST of Urocanate hydratase vs. Ensembl Celegans
Match: Y51H4A.7 (Probable urocanate hydratase [Source:UniProtKB/Swiss-Prot;Acc:Q9NAE2])

HSP 1 Score: 723.776 bits (1867), Expect = 0.000e+0
Identity = 365/684 (53.36%), Postives = 475/684 (69.44%), Query Frame = 2 
Query:  110 LNILSLGI-PLVPLPEN--NGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYP 2152
            +NI SL + P  PL E+     + +  HA      LT ++K L+V+NAL+Y PK  H  L  EF  EL TYGHIY YRF P  ++  A  +    A   +A+AI+LMI NNLD  +AQ+P+ELVTYGGNGQVFSNW Q+ +V+++L  M   QTLV+YSGHPLGLFP+ P  +SP+M ++NGM++P+YS+   Y+K FALGV+QYGQMTAGS+CYIGPQGIVHGT++T++NA R           S   KVFVT+GLGGMSGAQ KA+ IA CIGVIAE+S TAL KR  QGW++  +  + E++  I+++ +  +  SIG  GNVVDLWE L +      E L ++GSDQTS H    GG+YPAGL++E+S  +M  D  KFK LV  SL +Q+ AI+ ++ KGMYF+DYGNAFLL+  R+GA++  ++   + S     F+YPSY+QDIMG IFSMGFGPFRW+C+S   +DL  TD+ A K I+++         KD      VK QY DN  WI+ A+   LVVGS+ARILY+D  GRV +A AFNE + +  VSA I++SRDHHDVSGTDSPFRETSN+YDGSA  ADMA+QN IGDSFRGATWVA+HNGGG GWG+ INGGFG++LDGS +A  ++  ML WDV NG++RR WSGN  A+  ++R   +   L +  P
Sbjct:    1 MNIPSLFVDPFSPLLEHPTEQRAKNVAHAPKRPCNLTQTEKMLAVRNALRYIPKEHHVLLATEFAEELNTYGHIYGYRFMPNFDLF-APPVSEIGAHCEQASAIILMILNNLDKRVAQFPQELVTYGGNGQVFSNWIQFRLVLRYLYTMTDHQTLVLYSGHPLGLFPSTP--DSPRMTVTNGMMIPSYSTKELYDKYFALGVTQYGQMTAGSFCYIGPQGIVHGTTITVLNAGRRMGLD------SLAGKVFVTAGLGGMSGAQPKAAKIAGCIGVIAEISDTALLKRHQQGWLDVYSKDLEEIVNWIKEYREKKEAISIGYLGNVVDLWERLAEEP----ECLVELGSDQTSLHNPFLGGFYPAGLTFEQSNQMMTSDPVKFKKLVQNSLIRQIAAIDKIAAKGMYFWDYGNAFLLECQRAGANLLREDAQDDKS-----FRYPSYMQDIMGDIFSMGFGPFRWVCTSGKPEDLRLTDQTACKIIDEL---------KDTDVPEYVKQQYLDNKKWIEEAEKNKLVVGSQARILYSDRAGRVALASAFNELVKSGKVSAAIVISRDHHDVSGTDSPFRETSNVYDGSAFTADMAVQNCIGDSFRGATWVALHNGGGVGWGDVINGGFGIVLDGSSDAARRAEGMLNWDVPNGVTRRSWSGNAKAQEAIQRAEKQVDGLRVTLP 657
[Close]
BLAST of Urocanate hydratase vs. Ensembl Zebrafish
Match: uroc1 (urocanate hydratase 1 [Source:ZFIN;Acc:ZDB-GENE-081022-148])

HSP 1 Score: 823.928 bits (2127), Expect = 0.000e+0
Identity = 393/668 (58.83%), Postives = 491/668 (73.50%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMER 2113
            L  +  G+PL PLP N G   S PHA V    LT ++++++++NAL+YFP +LH  L  EF  EL  YGHIYMYRF P    +RAY I  YP K   AA+IMLMI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+V+ +LS M  +QTLVMYSGHPLGLFP+ P  +SP+ VI+NGMV+PNYSS  +YEK+FA+G++ YGQMTAGSYCYIGPQGIVHGT LT++NA R    S     +  R +VFVTSGLGGMSGAQAKA+VIA C+GVIAEV +  L+KR  QGW+ ++ + +   I++IR+  K+    S+G +GN+VDLWE L    K TGELL D+GSDQTS H    GGYYP  L++ ++  LMN D  +FK LVHESLR+ V AIN LS+ GM+F+DYGNAFLL+A R+GADV              +FKYPSYVQ IMG IFS+GFGPFRW+C+S D  DLV+TD IA   +E I S          +    V+ QY DN+ WI+ A  + +VVGS+ARILY+D  GRV+IA A N+AIA   VSAP+++SRDHHDVSGTDSPFRETSN+YDGSA CADMA+QN +GD+FRGATWV++HNGGG GWGE INGGFGL+LDGS+EA  ++ +ML WDV NG++RR WSGN  A  T++R
Sbjct:    4 LKEICAGLPLDPLPPNRGRDPSVPHAPVRTPNLTPAEERVALRNALRYFPPSLHATLAVEFAQELRQYGHIYMYRFCPALR-MRAYPIGQYPCKTRHAASIMLMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVLHYLSTMTEEQTLVMYSGHPLGLFPSLP--SSPRCVITNGMVIPNYSSREEYEKMFAMGITMYGQMTAGSYCYIGPQGIVHGTMLTVLNAGRRYLGS-----SDLRGRVFVTSGLGGMSGAQAKAAVIAGCVGVIAEVDEAPLKKRHEQGWLMEVTSDLSHCIQRIREAKKAGTALSLGYHGNIVDLWECLYQEFKKTGELLVDLGSDQTSLHNPFSGGYYPVQLTFRQASQLMNTDPQRFKTLVHESLRRHVAAINNLSDAGMFFWDYGNAFLLEAQRAGADV------QKKGGGATEFKYPSYVQHIMGDIFSLGFGPFRWVCTSGDPADLVETDAIATAVLEDISS----------TVTERVRQQYSDNIRWIREAGKHKMVVGSQARILYSDQRGRVSIALAINQAIAEGRVSAPVVISRDHHDVSGTDSPFRETSNVYDGSAFCADMAVQNFVGDAFRGATWVSLHNGGGVGWGEVINGGFGLVLDGSEEAERRARTMLNWDVSNGVARRCWSGNANAYETIQR 647
[Close]
BLAST of Urocanate hydratase vs. Ensembl Xenopus
Match: p4ha2 (prolyl 4-hydroxylase, alpha polypeptide 2 [Source:Xenbase;Acc:XB-GENE-957618])

HSP 1 Score: 793.882 bits (2049), Expect = 0.000e+0
Identity = 396/720 (55.00%), Postives = 503/720 (69.86%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKI--------------------------------------RDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPN 2155
            L  L  G+PL PLP+N G ++  PHA      L+  +++L+++NAL+YFP  LH  L  EF  EL  YGHIYMYRF P  + ++AY I  YP K   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+VM +LS+M  +QTLVMYSGHPLGLFP++    +P++VI+NGMV+PNYSS  DYEK+FALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  + S   KVFVTSGLGGMSGAQAKA+ I  C+GVIAEV ++AL KR  QGW+ ++ NS+   I++I                                      +   K  +  S+G +GN+VDLWE LV+ ++ TGELL D+GSDQTSCH    GGYYP  L++ ++  ++ +D   F  LVHESL++QV AIN L +KGM+F+DYGNAFLL+A R+GADV    Q H     +  F+YPSYVQ IMG IFS+GFGPFRW+C+S D  DL  TDEIA+  +E I++    +          VK QY DN+ WI+ A  + LVVGS+ARILY+D +GRV+IA A N A+A   V  P+++SRDHHDVSGTDSP+RETSNIYDGSA CADMA+QN +GDSFRGATWVA+HNGGG GWGE INGGFGL+LDGS+EA E++  ML WDV NG++RR WSGN+ A  T+ R   + +NL++  P+
Sbjct:    9 LTELCAGLPLSPLPQNKGRNNGVPHAPNRTPQLSAEEERLALENALRYFPPELHGTLAPEFADELRHYGHIYMYRFYPNIQ-MKAYPITQYPCKTRHAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVMHYLSEMTEEQTLVMYSGHPLGLFPSHS--GAPRVVITNGMVIPNYSSRRDYEKMFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGLDDLSG--KVFVTSGLGGMSGAQAKAASIVGCVGVIAEVDESALMKRHQQGWLMEVTNSLDGCIQRISVIWWGKGWVWVDYGWGFVIMKHNWGGPPPPLAWPFSAKRAKKDKEMLSLGYHGNIVDLWERLVEEYEKTGELLVDLGSDQTSCHNPFSGGYYPVQLTFSEANQMLCKDPQAFHQLVHESLKRQVAAINKLGDKGMFFWDYGNAFLLEAQRAGADV----QKHGGRDTE--FRYPSYVQHIMGDIFSLGFGPFRWVCTSADPSDLAATDEIASCALEDIIAQGVSDA---------VKKQYNDNIRWIREAGKHDLVVGSQARILYSDQKGRVSIAVAINRAVAAGRVKGPVVISRDHHDVSGTDSPYRETSNIYDGSAFCADMAVQNFVGDSFRGATWVALHNGGGVGWGEVINGGFGLVLDGSQEAEERATRMLSWDVSNGVARRCWSGNQNAYDTIVRTMEENRNLKVTLPH 705
[Close]
BLAST of Urocanate hydratase vs. Ensembl Xenopus
Match: p4ha2 (prolyl 4-hydroxylase, alpha polypeptide 2 [Source:Xenbase;Acc:XB-GENE-957618])

HSP 1 Score: 739.569 bits (1908), Expect = 0.000e+0
Identity = 361/616 (58.60%), Postives = 454/616 (73.70%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTG 1957
            L  L  G+PL PLP+N G ++  PHA      L+  +++L+++NAL+YFP  LH  L  EF  EL  YGHIYMYRF P  + ++AY I  YP K   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+VM +LS+M  +QTLVMYSGHPLGLFP++    +P++VI+NGMV+PNYSS  DYEK+FALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  + S   KVFVTSGLGGMSGAQAKA+ I  C+GVIAEV ++AL KR  QGW+ ++ NS+   I++IR   K  +  S+G +GN+VDLWE LV+ ++ TGELL D+GSDQTSCH    GGYYP  L++ ++  ++ +D   F  LVHESL++QV AIN L +KGM+F+DYGNAFLL+A R+GADV    Q H     +  F+YPSYVQ IMG IFS+GFGPFRW+C+S D  DL  TDEIA+  +E I++    +          VK QY DN+ WI+ A  + LVVGS+ARILY+D +GRV+IA A N A+A   V  P+++SRDHHDVSGTDSP+RETSNIYDGSA CADMA+QN +GDSFRGATWVA+HNGGG G
Sbjct:    4 LQELCAGLPLSPLPQNKGRNNGVPHAPNRTPQLSAEEERLALENALRYFPPELHGTLAPEFADELRHYGHIYMYRFYPNIQ-MKAYPITQYPCKTRHAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVMHYLSEMTEEQTLVMYSGHPLGLFPSHS--GAPRVVITNGMVIPNYSSRRDYEKMFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGLDDLSG--KVFVTSGLGGMSGAQAKAASIVGCVGVIAEVDESALMKRHQQGWLMEVTNSLDGCIQRIRKAKKDKEMLSLGYHGNIVDLWERLVEEYEKTGELLVDLGSDQTSCHNPFSGGYYPVQLTFSEANQMLCKDPQAFHQLVHESLKRQVAAINKLGDKGMFFWDYGNAFLLEAQRAGADV----QKHGGRDTE--FRYPSYVQHIMGDIFSLGFGPFRWVCTSADPSDLAATDEIASCALEDIIAQGVSD---------AVKKQYNDNIRWIREAGKHDLVVGSQARILYSDQKGRVSIAVAINRAVAAGRVKGPVVISRDHHDVSGTDSPYRETSNIYDGSAFCADMAVQNFVGDSFRGATWVALHNGGGVG 596
[Close]
BLAST of Urocanate hydratase vs. Ensembl Xenopus
Match: p4ha2 (prolyl 4-hydroxylase, alpha polypeptide 2 [Source:Xenbase;Acc:XB-GENE-957618])

HSP 1 Score: 736.102 bits (1899), Expect = 0.000e+0
Identity = 373/682 (54.69%), Postives = 476/682 (69.79%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPN 2155
            L  L  G+PL PLP+N G ++  PHA      L+  +++L+++NAL+YFP  LH  L  EF  EL  YGHIYMYRF P  + ++AY I  YP K   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+VM +LS+M  +QTLVMYSGHPLGLFP++    +P++VI+NGMV+PNYSS  DYEK+FALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  + S   KVFVTSGLGGMSGAQAKA+ I  C+GVIAEV ++AL KR  QGW+ ++ NS+   I++IR   K  +  S+G +GN+VDL    +   K +G L  D        +I   G +    ++                  ++ SL++QV AIN L +KGM+F+DYGNAFLL+A R+GADV    Q H     +  F+YPSYVQ IMG IFS+GFGPFRW+C+S D  DL  TDEIA+  +E I++    +          VK QY DN+ WI+ A  + LVVGS+ARILY+D +GRV+IA A N A+A   V  P+++SRDHHDVSGTDSP+RETSNIYDGSA CADMA+QN +GDSFRGATWVA+HNGGG GWGE INGGFGL+LDGS+EA E++  ML WDV NG++RR WSGN+ A  T+ R   + +NL++  P+
Sbjct:    4 LQELCAGLPLSPLPQNKGRNNGVPHAPNRTPQLSAEEERLALENALRYFPPELHGTLAPEFADELRHYGHIYMYRFYPNIQ-MKAYPITQYPCKTRHAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVMHYLSEMTEEQTLVMYSGHPLGLFPSHS--GAPRVVITNGMVIPNYSSRRDYEKMFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGLDDLSG--KVFVTSGLGGMSGAQAKAASIVGCVGVIAEVDESALMKRHQQGWLMEVTNSLDGCIQRIRKAKKDKEMLSLGYHGNIVDLCGRYL---KFSGRLYTD--------YIFFCGRFTCPLIT---------------TLALYSSLKRQVAAINKLGDKGMFFWDYGNAFLLEAQRAGADV----QKHGGRDTE--FRYPSYVQHIMGDIFSLGFGPFRWVCTSADPSDLAATDEIASCALEDIIAQGVSD---------AVKKQYNDNIRWIREAGKHDLVVGSQARILYSDQKGRVSIAVAINRAVAAGRVKGPVVISRDHHDVSGTDSPYRETSNIYDGSAFCADMAVQNFVGDSFRGATWVALHNGGGVGWGEVINGGFGLVLDGSQEAEERATRMLSWDVSNGVARRCWSGNQNAYDTIVRTMEENRNLKVTLPH 636
[Close]
BLAST of Urocanate hydratase vs. Ensembl Xenopus
Match: p4ha2 (prolyl 4-hydroxylase, alpha polypeptide 2 [Source:Xenbase;Acc:XB-GENE-957618])

HSP 1 Score: 736.102 bits (1899), Expect = 0.000e+0
Identity = 370/682 (54.25%), Postives = 465/682 (68.18%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPN 2155
            L  L  G+PL PLP+N G ++  PHA      L+  +++L+++NAL+YFP  LH  L  EF  EL  YGHIYMYRF P  + ++AY I  YP K   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ                                             V+PNYSS  DYEK+FALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  + S   KVFVTSGLGGMSGAQAKA+ I  C+GVIAEV ++AL KR  QGW+ ++ NS+   I++IR   K  +  S+G +GN+VDLWE LV+ ++ TGELL D+GSDQTSCH    GGYYP  L++ ++  ++ +D   F  LVHESL++QV AIN L +KGM+F+DYGNAFLL+A R+GADV    Q H     +  F+YPSYVQ IMG IFS+GFGPFRW+C+S D  DL  TDEIA+  +E I++    +          VK QY DN+ WI+ A  + LVVGS+ARILY+D +GRV+IA A N A+A   V  P+++SRDHHDVSGTDSP+RETSNIYDGSA CADMA+QN +GDSFRGATWVA+HNGGG GWGE INGGFGL+LDGS+EA E++  ML WDV NG++RR WSGN+ A  T+ R   + +NL++  P+
Sbjct:    4 LQELCAGLPLSPLPQNKGRNNGVPHAPNRTPQLSAEEERLALENALRYFPPELHGTLAPEFADELRHYGHIYMYRFYPNIQ-MKAYPITQYPCKTRHAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQ---------------------------------------------VIPNYSSRRDYEKMFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGLDDLSG--KVFVTSGLGGMSGAQAKAASIVGCVGVIAEVDESALMKRHQQGWLMEVTNSLDGCIQRIRKAKKDKEMLSLGYHGNIVDLWERLVEEYEKTGELLVDLGSDQTSCHNPFSGGYYPVQLTFSEANQMLCKDPQAFHQLVHESLKRQVAAINKLGDKGMFFWDYGNAFLLEAQRAGADV----QKHGGRDTE--FRYPSYVQHIMGDIFSLGFGPFRWVCTSADPSDLAATDEIASCALEDIIAQGVSDA---------VKKQYNDNIRWIREAGKHDLVVGSQARILYSDQKGRVSIAVAINRAVAAGRVKGPVVISRDHHDVSGTDSPYRETSNIYDGSAFCADMAVQNFVGDSFRGATWVALHNGGGVGWGEVINGGFGLVLDGSQEAEERATRMLSWDVSNGVARRCWSGNQNAYDTIVRTMEENRNLKVTLPH 619
[Close]
BLAST of Urocanate hydratase vs. Ensembl Xenopus
Match: p4ha2 (prolyl 4-hydroxylase, alpha polypeptide 2 [Source:Xenbase;Acc:XB-GENE-957618])

HSP 1 Score: 722.235 bits (1863), Expect = 0.000e+0
Identity = 372/714 (52.10%), Postives = 476/714 (66.67%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRN----QKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKI--------------------------RDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGS--DQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPN 2155
            L  L  G+PL PLP+N G ++  PHA      L+  +++L+++NAL+YFP  LH  L  EF  EL  YGHIYMYRF P  + ++AY I  YP K   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+VM +LS+M  +QTLVMYSGHPLGLFP++    +P++VI+NGMV+PNYSS  DYEK+FALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R        SG         KVFVTSGLGGMSGAQAKA+ I  C+GVIAEV ++AL KR  QGW+ ++ NS+   I++I                          R   K  +  S+G +GN+VDL  A +        + A+  S  + T   +  +  ++    +      L           ++ SL++QV AIN L +KGM+F+DYGNAFLL+A R+GADV    Q H       +F+YPSYVQ IMG IFS+GFGPFRW+C+S D  DL  TDEIA+  +E I++    +          VK QY DN+ WI+ A  + LVVGS+ARILY+D +GRV+IA A N A+A   V  P+++SRDHHDVSGTDSP+RETSNIYDGSA CADMA+QN +GDSFRGATWVA+HNGGG GWGE INGGFGL+LDGS+EA E++  ML WDV NG++RR WSGN+ A  T+ R   + +NL++  P+
Sbjct:    4 LQELCAGLPLSPLPQNKGRNNGVPHAPNRTPQLSAEEERLALENALRYFPPELHGTLAPEFADELRHYGHIYMYRFYPNIQ-MKAYPITQYPCKTRHAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVMHYLSEMTEEQTLVMYSGHPLGLFPSHS--GAPRVVITNGMVIPNYSSRRDYEKMFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGRRYLGLDDLSG---------KVFVTSGLGGMSGAQAKAASIVGCVGVIAEVDESALMKRHQQGWLMEVTNSLDGCIQRISPLLNCGSVKIGARVERNMKFCFSLYRKAKKDKEMLSLGYHGNIVDLCHASIRSVSQCITISAETVSTAEPTGGRLYTDYIFFCGRFTCPLITTLA----------LYSSLKRQVAAINKLGDKGMFFWDYGNAFLLEAQRAGADV----QKHGGR--DTEFRYPSYVQHIMGDIFSLGFGPFRWVCTSADPSDLAATDEIASCALEDIIAQGVSD---------AVKKQYNDNIRWIREAGKHDLVVGSQARILYSDQKGRVSIAVAINRAVAAGRVKGPVVISRDHHDVSGTDSPYRETSNIYDGSAFCADMAVQNFVGDSFRGATWVALHNGGGVGWGEVINGGFGLVLDGSQEAEERATRMLSWDVSNGVARRCWSGNQNAYDTIVRTMEENRNLKVTLPH 680
[Close]
BLAST of Urocanate hydratase vs. Ensembl Mouse
Match: Uroc1 (urocanase domain containing 1 [Source:MGI Symbol;Acc:MGI:2385332])

HSP 1 Score: 801.971 bits (2070), Expect = 0.000e+0
Identity = 390/662 (58.91%), Postives = 487/662 (73.56%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETA 2095
            L  L  G+PL PLPEN G  +  PHA V    L+  +++L+++NAL+YFP ++ + L  EF  EL  +GHIYMYRF P  E +RAY ID YP +   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+ + M +LS+M  +QTLVMYSGHPLGLFP++P   +P++VI+NGMV+PNYSS  +YEKLFALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  N +   KVFVTSGLGGMSGAQAKA+ I  CIGVIAEV K AL KR  QGW+ ++ +S+   I ++R+  K  +  S+G +GNVVDLWE LV    +TGELL D+GSDQTSCH    GGYYP  LS+ +++ LM+ +   FK LV ESLR+ V AIN L+ +  +F+DYGNAFLL+A R+GADV            + +F+YPSYVQ IMG IFS GFGPFRW+C+S D +DL  TD +A   +EK +++           K +VKLQY DN+ WI+ A  + LVVGS+ARILY+D +GRV IA A N+AIA+  + AP++LSRDHHDVSGTDSPFRETSNIYDGSA CADMA+QN +GD+ RGATWVA+HNGGG GWGE INGGFGL+LDG+ EA +K+  ML WDV NG++RR WSGN  A
Sbjct:    4 LQELCSGLPLRPLPENRGRWAGVPHAPVRTPNLSPEEEQLALRNALRYFPPDVQKLLALEFAQELRQFGHIYMYRFCPSIE-MRAYPIDQYPCRTRAAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFRLTMSYLSKMTEEQTLVMYSGHPLGLFPSSP--RAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGIENLAG--KVFVTSGLGGMSGAQAKAAAIVGCIGVIAEVDKAALVKRHRQGWLMEVTDSLDRCIARLREARKKKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLSFSEAQSLMSSNPAAFKHLVQESLRRHVAAINRLAQEKFFFWDYGNAFLLEAQRAGADV------EKKGANKMEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDHLATSVLEKAIAD---------GVKASVKLQYMDNIRWIREAAKHQLVVGSQARILYSDQKGRVAIAVAINQAIASGKIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTAEAEQKARMMLSWDVSNGVARRCWSGNPKA 642
[Close]
BLAST of Urocanate hydratase vs. Ensembl Mouse
Match: Uroc1 (urocanase domain containing 1 [Source:MGI Symbol;Acc:MGI:2385332])

HSP 1 Score: 786.563 bits (2030), Expect = 0.000e+0
Identity = 392/696 (56.32%), Postives = 489/696 (70.26%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIR-------------------------------DHMKSNKPT---SIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETA 2095
            L  L  G+PL PLPEN G  +  PHA V    L+  +++L+++NAL+YFP ++ + L  EF  EL  +GHIYMYRF P  E +RAY ID YP +   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+ + M +LS+M  +QTLVMYSGHPLGLFP++P   +P++VI+NGMV+PNYSS  +YEKLFALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  N +   KVFVTSGLGGMSGAQAKA+ I  CIGVIAEV K AL KR  QGW+ ++ +S+   I ++R                               DH ++ K     S+G +GNVVDLWE LV    +TGELL D+GSDQTSCH    GGYYP  LS+ +++ LM+ +   FK LV ESLR+ V AIN L+ +  +F+DYGNAFLL+A R+GADV            + +F+YPSYVQ IMG IFS GFGPFRW+C+S D +DL  TD +A   +EK +++           K +VKLQY DN+ WI+ A  + LVVGS+ARILY+D +GRV IA A N+AIA+  + AP++LSRDHHDVSGTDSPFRETSNIYDGSA CADMA+QN +GD+ RGATWVA+HNGGG GWGE INGGFGL+LDG+ EA +K+  ML WDV NG++RR WSGN  A
Sbjct:    4 LQELCSGLPLRPLPENRGRWAGVPHAPVRTPNLSPEEEQLALRNALRYFPPDVQKLLALEFAQELRQFGHIYMYRFCPSIE-MRAYPIDQYPCRTRAAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFRLTMSYLSKMTEEQTLVMYSGHPLGLFPSSP--RAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGIENLAG--KVFVTSGLGGMSGAQAKAAAIVGCIGVIAEVDKAALVKRHRQGWLMEVTDSLDRCIARLRYGLAVWDPEHLTLSTGSRGESMTWAIQCLMFDHREARKKKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLSFSEAQSLMSSNPAAFKHLVQESLRRHVAAINRLAQEKFFFWDYGNAFLLEAQRAGADV------EKKGANKMEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDHLATSVLEKAIAD---------GVKASVKLQYMDNIRWIREAAKHQLVVGSQARILYSDQKGRVAIAVAINQAIASGKIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTAEAEQKARMMLSWDVSNGVARRCWSGNPKA 676
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BLAST of Urocanate hydratase vs. UniProt/SwissProt
Match: sp|Q96N76|HUTU_HUMAN (Urocanate hydratase OS=Homo sapiens OX=9606 GN=UROC1 PE=1 SV=1)

HSP 1 Score: 810.831 bits (2093), Expect = 0.000e+0
Identity = 390/666 (58.56%), Postives = 492/666 (73.87%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRN----QKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETA 2095
            L  L  G+PL PLPEN G  +  PHA V    L+  +K+L+++NAL+YFP ++ E L  EF  EL+ YGHIYMYRF P  E +RAY I+ YP +   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+ M +LS+M  +QTLVMYSGHPLGLFP++   ++P++VI+NGMV+PNYSS  +YEKLFALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R     +  +G         KVFVTSGLGGMSGAQAKA+VI  CIGVIAEV K AL+KR  QGW+ ++ +S+   I+++R+  K  +  S+G +GNVV LWE LV    +TGE L D+GSDQTSCH    GGYYP  LS+ +++ LM  +   FK LV ESLR+QV+AIN L+ +  +F+DYGNAFLL+A R+GADV            + +F+YPSYVQ IMG IFS GFGPFRW+C+S D +DL  TDE+A   +E+ +++           K++VKLQY DN+ WI+ A  + LVVGS+ARILY+D +GRV IA A N+AIA + + AP++LSRDHHDVSGTDSPFRETSNIYDGSA CADMA+QN +GD+ RGATWVA+HNGGG GWGE INGGFGL+LDG+ EA  ++  ML WDV NG++RR WSGN+ A
Sbjct:    4 LQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIE-MRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSS--RSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAG---------KVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADV------EKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIAD---------GVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKA 642
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BLAST of Urocanate hydratase vs. UniProt/SwissProt
Match: sp|Q8VC12|HUTU_MOUSE (Urocanate hydratase OS=Mus musculus OX=10090 GN=Uroc1 PE=1 SV=2)

HSP 1 Score: 801.971 bits (2070), Expect = 0.000e+0
Identity = 390/662 (58.91%), Postives = 487/662 (73.56%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETA 2095
            L  L  G+PL PLPEN G  +  PHA V    L+  +++L+++NAL+YFP ++ + L  EF  EL  +GHIYMYRF P  E +RAY ID YP +   AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+ + M +LS+M  +QTLVMYSGHPLGLFP++P   +P++VI+NGMV+PNYSS  +YEKLFALGV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  N +   KVFVTSGLGGMSGAQAKA+ I  CIGVIAEV K AL KR  QGW+ ++ +S+   I ++R+  K  +  S+G +GNVVDLWE LV    +TGELL D+GSDQTSCH    GGYYP  LS+ +++ LM+ +   FK LV ESLR+ V AIN L+ +  +F+DYGNAFLL+A R+GADV            + +F+YPSYVQ IMG IFS GFGPFRW+C+S D +DL  TD +A   +EK +++           K +VKLQY DN+ WI+ A  + LVVGS+ARILY+D +GRV IA A N+AIA+  + AP++LSRDHHDVSGTDSPFRETSNIYDGSA CADMA+QN +GD+ RGATWVA+HNGGG GWGE INGGFGL+LDG+ EA +K+  ML WDV NG++RR WSGN  A
Sbjct:    4 LQELCSGLPLRPLPENRGRWAGVPHAPVRTPNLSPEEEQLALRNALRYFPPDVQKLLALEFAQELRQFGHIYMYRFCPSIE-MRAYPIDQYPCRTRAAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFRLTMSYLSKMTEEQTLVMYSGHPLGLFPSSP--RAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGIENLAG--KVFVTSGLGGMSGAQAKAAAIVGCIGVIAEVDKAALVKRHRQGWLMEVTDSLDRCIARLREARKKKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLSFSEAQSLMSSNPAAFKHLVQESLRRHVAAINRLAQEKFFFWDYGNAFLLEAQRAGADV------EKKGANKMEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDHLATSVLEKAIAD---------GVKASVKLQYMDNIRWIREAAKHQLVVGSQARILYSDQKGRVAIAVAINQAIASGKIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTAEAEQKARMMLSWDVSNGVARRCWSGNPKA 642
[Close]
BLAST of Urocanate hydratase vs. UniProt/SwissProt
Match: sp|Q86AX3|HUTU_DICDI (Probable urocanate hydratase OS=Dictyostelium discoideum OX=44689 GN=uroc1 PE=3 SV=2)

HSP 1 Score: 748.043 bits (1930), Expect = 0.000e+0
Identity = 383/695 (55.11%), Postives = 488/695 (70.22%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERI--KVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY*NRNLFILVN 2188
            L+ LS GIP  PLPE+ G  S+ PHA      LT ++KKL++KN+L+YFP +LH  L  EF  EL  YGHIYMYRF+P    ++AY I+ YPAK  +AA+IMLMI NNLD ++AQ+P ELVTYGGNG VF NWAQY + MK+LS+M   QTL MYSGHP+GLFP+N   +SP+++++NGMV+PNYSS  DYE+++A GV+QYGQMTAGSYCYIGPQGIVHGT++TL+NA       G K    E +  KVFV+SGLGGMSGAQ KA+ I   I ++AEVS  A++KR +Q WV ++ + + E+  +     K  KP SI   GNVV LWE LV+      ++  D+GSDQTS H    GGYYP   S+E+S  LM Q+  KFK +V E+LR+   AIN LS +GM F+DYGN+FLL+A R+ AD+          T   +F YPSYVQDIMG IFS+GFGPFRW+C+S + KDL  TD IA + IEK+ S              NV+ Q+ DN  WI  A  + LVVGS+ARILY+D  GR  +A AFN+A+A+  +SAP+++SRDHHDVSGTD+P+RETSNI DGS  CADMAI NVIGDSFRGATWVAIHNGGGTG+GEAINGGFGL L GSK   EK+  ML WDV NG++RR WS N+ A +T++R      +L++  PN+ + +L   +N
Sbjct:    5 LSSLSKGIPFEPLPEHPGLDSTVPHAPGRPINLTLNEKKLAIKNSLRYFPNSLHSILANEFLEELNKYGHIYMYRFRPTHYEMKAYPIEEYPAKSRQAASIMLMIMNNLDREVAQFPNELVTYGGNGSVFQNWAQYHLTMKYLSEMTDQQTLTMYSGHPMGLFPSNE--SSPRVIVTNGMVIPNYSSHKDYERMYAQGVTQYGQMTAGSYCYIGPQGIVHGTTITLLNA-------GRKYLGVESLIGKVFVSSGLGGMSGAQTKAAYICGAICIVAEVSPAAVKKRHAQNWVMEVYSDLNELFAR-GSCSKEKKPLSIAYQGNVVTLWEKLVEEK----DITVDLGSDQTSLHNPFNGGYYPVQCSFEESNRLMVQEPTKFKEMVQETLRRHTTAINALSARGMKFWDYGNSFLLEASRAKADII------KPGTDGKEFIYPSYVQDIMGDIFSLGFGPFRWVCTSGNPKDLEITDRIAKELIEKLRSQP--------GVPKNVQQQFNDNHLWISQAGEHKLVVGSQARILYSDCIGRSELAVAFNKAVADGTLSAPVVISRDHHDVSGTDAPWRETSNIKDGSQFCADMAIHNVIGDSFRGATWVAIHNGGGTGFGEAINGGFGLYLCGSKLQEEKARMMLNWDVNNGIARRSWSYNDNAENTIKRAMELDPSLKVTIPNHTSDDLINSLN 671
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BLAST of Urocanate hydratase vs. UniProt/SwissProt
Match: sp|Q9NAE2|HUTU_CAEEL (Probable urocanate hydratase OS=Caenorhabditis elegans OX=6239 GN=Y51H4A.7 PE=3 SV=2)

HSP 1 Score: 723.776 bits (1867), Expect = 0.000e+0
Identity = 365/684 (53.36%), Postives = 475/684 (69.44%), Query Frame = 2 
Query:  110 LNILSLGI-PLVPLPEN--NGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYP 2152
            +NI SL + P  PL E+     + +  HA      LT ++K L+V+NAL+Y PK  H  L  EF  EL TYGHIY YRF P  ++  A  +    A   +A+AI+LMI NNLD  +AQ+P+ELVTYGGNGQVFSNW Q+ +V+++L  M   QTLV+YSGHPLGLFP+ P  +SP+M ++NGM++P+YS+   Y+K FALGV+QYGQMTAGS+CYIGPQGIVHGT++T++NA R           S   KVFVT+GLGGMSGAQ KA+ IA CIGVIAE+S TAL KR  QGW++  +  + E++  I+++ +  +  SIG  GNVVDLWE L +      E L ++GSDQTS H    GG+YPAGL++E+S  +M  D  KFK LV  SL +Q+ AI+ ++ KGMYF+DYGNAFLL+  R+GA++  ++   + S     F+YPSY+QDIMG IFSMGFGPFRW+C+S   +DL  TD+ A K I+++         KD      VK QY DN  WI+ A+   LVVGS+ARILY+D  GRV +A AFNE + +  VSA I++SRDHHDVSGTDSPFRETSN+YDGSA  ADMA+QN IGDSFRGATWVA+HNGGG GWG+ INGGFG++LDGS +A  ++  ML WDV NG++RR WSGN  A+  ++R   +   L +  P
Sbjct:    1 MNIPSLFVDPFSPLLEHPTEQRAKNVAHAPKRPCNLTQTEKMLAVRNALRYIPKEHHVLLATEFAEELNTYGHIYGYRFMPNFDLF-APPVSEIGAHCEQASAIILMILNNLDKRVAQFPQELVTYGGNGQVFSNWIQFRLVLRYLYTMTDHQTLVLYSGHPLGLFPSTP--DSPRMTVTNGMMIPSYSTKELYDKYFALGVTQYGQMTAGSFCYIGPQGIVHGTTITVLNAGRRMGLD------SLAGKVFVTAGLGGMSGAQPKAAKIAGCIGVIAEISDTALLKRHQQGWLDVYSKDLEEIVNWIKEYREKKEAISIGYLGNVVDLWERLAEEP----ECLVELGSDQTSLHNPFLGGFYPAGLTFEQSNQMMTSDPVKFKKLVQNSLIRQIAAIDKIAAKGMYFWDYGNAFLLECQRAGANLLREDAQDDKS-----FRYPSYMQDIMGDIFSMGFGPFRWVCTSGKPEDLRLTDQTACKIIDEL---------KDTDVPEYVKQQYLDNKKWIEEAEKNKLVVGSQARILYSDRAGRVALASAFNELVKSGKVSAAIVISRDHHDVSGTDSPFRETSNVYDGSAFTADMAVQNCIGDSFRGATWVALHNGGGVGWGDVINGGFGIVLDGSSDAARRAEGMLNWDVPNGVTRRSWSGNAKAQEAIQRAEKQVDGLRVTLP 657
[Close]
BLAST of Urocanate hydratase vs. UniProt/SwissProt
Match: sp|Q978N4|HUTU_THEVO (Probable urocanate hydratase OS=Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) OX=273116 GN=hutU PE=3 SV=1)

HSP 1 Score: 326.635 bits (836), Expect = 1.458e-101
Identity = 197/572 (34.44%), Postives = 306/572 (53.50%), Query Frame = 2 
Query:  398 EAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMER 2113
            EAA  +LM  NNLDP +A+ P  L+ YGG G+   NW  +  +++ L ++++D+TL++ SG P+G+F T    +SP+++I N  +VP++++   +  L A G++ +GQMTAGS+ YIG QG++ GT  TL    R + K           K  +TSGLG M GAQ  A  + N  G+I EV +  +++R    +++   +S+ E +    + +KS KPTSIGL GN   +++ L+  +     ++ D+ SDQT+ H L   GY P G + + +     +DKD +   V+ S+ K+  AI +    G   FDYGN F  +A   G              ++N F  P YV   +  +F++G GPFRW+  S D +D+ K D+   K            N +D+ + +           WIK A+      G  ARI Y     R  I    NE + N  VSAP+ + RDHHD     SP+RET  + DGS   AD  I N + ++  GATWV++H+GGGTG G AI+ GF ++ DG+K+A E+   +L  D   G+ R   +G E++   +++
Sbjct:   24 EAALRLLM--NNLDPMVAKDPANLIVYGGKGKAARNWEAFDKIVEELKKLENDETLLIQSGKPVGVFKTTK--DSPRVLIVNAQIVPHWATDDVFWDLEARGLTMFGQMTAGSWIYIGTQGVLQGTYETLSALARKEFKKDDLSG-----KWVLTSGLGEMGGAQPLAITMNNATGIIVEVDEEKIRRRLRDKYLDTWTDSLDEALRLKDEALKSGKPTSIGLLGNAATVYDELMKKN-----IVPDVVSDQTAAHDL-NLGYIPEGYTVQSAAEFREKDKDGYVKKVYASIVKEAEAILWFMQHGSKAFDYGNNFRTRALEGG--------------LKNAFDIPGYVPAYIRDLFAIGSGPFRWVALSGDPQDIYKIDDAIIK------------NFQDDPHLIR----------WIKLAKERVHFQGLPARICYASYGEREKIGLMINEMVRNGEVSAPVAIGRDHHDTGSVASPYRETEKMKDGSDAIADWPILNALLNAISGATWVSVHHGGGTGIGNAIHAGFVIVADGTKDAEERIKRVLNADPGIGVIRHADAGYESSIEIIKK 544
[Close]
BLAST of Urocanate hydratase vs. TrEMBL
Match: A0A433TFY8 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_011744 PE=3 SV=1)

HSP 1 Score: 845.499 bits (2183), Expect = 0.000e+0
Identity = 405/690 (58.70%), Postives = 509/690 (73.77%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY*NRNLFI 2179
            L  L  GIP  PLPE        PHA +    L   ++KL+++NAL+YFP + HE L  EF  EL TYGHIYMYRF+P  E +RAY +D YP K   AAAIM MI NNLDP +AQ+P ELVTYGGNGQVFSNWAQ+ +VM +LSQM   QTLVMYSGHP+GLFP++P   +P++VI+NGM+VPNYSS   YEKLFALG + YGQMTAGSYCYIGPQGIVHGT+LT++NA R    +          KVFVT+GLGGMSGAQAKA+VI  CIGV+AEVS+ AL KR+ QGW+ ++  ++ ++I  +R   +  K  SIG +GN+VD+WE LV  ++ TG++LAD+GSDQTSCH    GGYYPA L YE++R +M+QD  +F+ LV ESL + V AIN L++KGM+FFDYGNAFLL+A R GADV   +  +  +     F+YPSYVQDIMG IFS+GFGPFRW+C+S D  DL KTDE+AA  IE++   +  ++         V+ QYEDN  WI+ A  + +VVGS+ARILY+D  GRV +ARAFN+A+A   + +P+++SRDHHDVSGTDSPFRETSNIYDGSA+CADMAIQNVIGDSFRGATWVAIHNGGG GWGE INGGFGL+LDGS++AGE++  ML+WDV NG++RR WSGN  A+ T++R     + L++  PN    N  I
Sbjct:   15 LEELCAGIPTDPLPEPEARDPDIPHAPIRTPDLNADEEKLALENALRYFPASTHETLAPEFAIELRTYGHIYMYRFRPNIE-MRAYPLDQYPCKTLHAAAIMHMIMNNLDPRVAQFPHELVTYGGNGQVFSNWAQFLLVMHYLSQMTDHQTLVMYSGHPMGLFPSSP--EAPRLVITNGMMVPNYSSRDSYEKLFALGATMYGQMTAGSYCYIGPQGIVHGTTLTILNAARKHLGTSDMAG-----KVFVTAGLGGMSGAQAKAAVICGCIGVVAEVSEEALMKRYHQGWIMEVVTTLDDLIALLRHARRRGKSLSIGYHGNIVDVWERLVMEYECTGDVLADLGSDQTSCHNPYLGGYYPASLHYEEARDMMHQDPVRFRRLVQESLCRHVKAINKLASKGMFFFDYGNAFLLEASRVGADVGRSDGLNGCT-----FRYPSYVQDIMGDIFSLGFGPFRWVCTSTDPSDLAKTDELAASVIEELARADVPKS---------VQQQYEDNAKWIREAGKHKMVVGSQARILYSDQAGRVALARAFNKAVAEGKIKSPVVISRDHHDVSGTDSPFRETSNIYDGSALCADMAIQNVIGDSFRGATWVAIHNGGGVGWGEVINGGFGLVLDGSEDAGERAERMLKWDVSNGVTRRCWSGNANAKETIQRTMKMTEGLQVTLPNAVEDNTLI 682
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BLAST of Urocanate hydratase vs. TrEMBL
Match: A0A3S4QGW7 (Urocanate hydratase-like isoform X1 OS=Dinothrombium tinctorium OX=1965070 GN=B4U79_00452 PE=3 SV=1)

HSP 1 Score: 843.958 bits (2179), Expect = 0.000e+0
Identity = 417/677 (61.60%), Postives = 499/677 (73.71%), Query Frame = 2 
Query:  119 LSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGN----ETARSTMERLNLKCKNL 2137
            L LG+P+ PLP        +PHA + NH L+    KL+V+NAL+YFP N H  L  EF  EL+ YGHIYMYRF P  E ++AY ID YP K  EAAAIMLMI NNLDP++AQ+P EL+TYGGNGQVFSNWAQ+WIVM  LS+M  +QTLVMYSGHPLGLFP+N L  SP+MVISNGMV+PNYSS  DY+++FALGV+ YGQMTAGSYCYIGPQGIVHGT++TL+NA R   ++        R KVFV+SGLGGMSGAQAKA+VI+ C+GVIAEVS  ALQKR+ QGWV +I + I  +I++IR+     + TSIG YGNVV +WE LV  ++ + ELL D+GSDQTSCH    GGYYP  LSY++S+ LM  D+ KF  LV  SL++   AIN L+  GM F+DYGNAFLL+A R+GA+V   +     +     FKYPSYVQ IMG IFSMGFGPFRW+C+SCD  DL +TD IA    EKIL+ +             V+ QY DNL WI+NA  + LVVGSKARILY+D EGR+ +A AFNEAIA   + API++SRDHHDVSGTDSPFRETSNIYDGSA  ADMAIQN IGD+FRGATWVAIHNGGG GWGE INGGFGL+LDGS EA EK+ +ML WDV NG+SRR W+GN    ET   TME  +L C  +
Sbjct:    6 LCLGLPINPLPPPKARDPRFPHAPIRNHNLSEDGCKLAVRNALRYFPPNTHSVLAPEFMAELKEYGHIYMYRFIPDIE-MKAYPIDSYPVKCKEAAAIMLMIMNNLDPNVAQFPHELITYGGNGQVFSNWAQFWIVMHCLSKMTREQTLVMYSGHPLGLFPSNAL--SPRMVISNGMVIPNYSSRDDYDRMFALGVTMYGQMTAGSYCYIGPQGIVHGTTITLLNAGRKYLRT-----NDLRGKVFVSSGLGGMSGAQAKAAVISGCVGVIAEVSGDALQKRYRQGWVSEIIDDIDMLIKRIREAKAKKEITSIGFYGNVVTVWERLVKEYEQSKELLVDLGSDQTSCHNPFNGGYYPVDLSYDESQNLMKDDQSKFITLVKISLKRHAIAINTLAEAGMAFWDYGNAFLLEAYRAGANVGAQHTEQGLN-----FKYPSYVQHIMGDIFSMGFGPFRWVCTSCDSNDLHETDAIACSVFEKILTRKNLPEY--------VRNQYNDNLKWIQNADEHKLVVGSKARILYSDQEGRIALATAFNEAIAKGKIKAPIVISRDHHDVSGTDSPFRETSNIYDGSAFTADMAIQNCIGDAFRGATWVAIHNGGGVGWGEVINGGFGLVLDGSNEANEKAVNMLSWDVSNGVSRRAWAGNFYAKETIARTMETNSLLCVTM 661
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BLAST of Urocanate hydratase vs. TrEMBL
Match: G1KP64 (Urocanate hydratase 1 OS=Anolis carolinensis OX=28377 GN=UROC1 PE=3 SV=2)

HSP 1 Score: 834.328 bits (2154), Expect = 0.000e+0
Identity = 404/676 (59.76%), Postives = 514/676 (76.04%), Query Frame = 2 
Query:  128 GIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPN 2155
            G+PL P+P+N G ++  PHA V    LT  +KKL++KNAL+YFP +LHE L  EF  EL+ YGHIYMYRF  P+ V+RAY I  YP K  +AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+VM +LS+M   QTLVMYSGHPLGLFP++   N+P++VI+NGMV+PNYSS  +YE++FA+GV+ YGQMTAGSYCYIGPQGIVHGT LT++NA R   +  G  N +   KVFVTSGLGGMSGAQAKA+VIA C+GVIAEV + AL KR  QGW+ +I NS+ + I ++R+  K     S+G +GNVVDLWE LV+  + TGELLAD+GSDQTSCH    GGYYP  L+++++  LM+ + +KF+ALV ESLRKQV AIN LS++G++F+DYGNAFLL+A R+GADV  DN+         +F+YPSYVQ IMG IFS+GFGPFRW+C+S + +DL  TD IA+  +E+ +  E            +VK QY DN+ WI+ A+ + LVVGS+ARILY+D +GRV IA A N+ IA   ++AP++LSRDHHDVSGTDSP+RETSNIYDGSA CADMA+QN +GDSFRGATWVA+HNGGG GWGE INGGFGL+LDGS +A E++  ML WDV NG++RR WSGN+ A  T+ +   K + L++  P+
Sbjct:   11 GLPLYPIPKNRGRTAGIPHAPVRTPSLTVQEKKLALKNALRYFPADLHEVLASEFAKELKLYGHIYMYRF-CPQIVMRAYPIQEYPCKTIQAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVMHYLSEMTEGQTLVMYSGHPLGLFPSH--RNAPRLVITNGMVIPNYSSREEYERMFAMGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGR---RYLGIENLAG--KVFVTSGLGGMSGAQAKAAVIAGCVGVIAEVDEAALLKRHQQGWLMEITNSLDQCIVRLREAKKRKTALSLGYHGNVVDLWERLVEEFEKTGELLADLGSDQTSCHNPFNGGYYPVQLTFKEANQLMSSNPEKFQALVQESLRKQVAAINKLSDQGLFFWDYGNAFLLEAQRAGADVGGDNK--------GEFRYPSYVQHIMGDIFSLGFGPFRWVCTSGNPEDLATTDCIASSVLEEAVLEEV---------NASVKQQYRDNIHWIQEARRHNLVVGSQARILYSDQKGRVAIAIAINQGIAGGRITAPVVLSRDHHDVSGTDSPYRETSNIYDGSAFCADMAVQNFVGDSFRGATWVALHNGGGVGWGEVINGGFGLVLDGSADAEERAKMMLSWDVSNGVARRCWSGNKNAYETICQAMEKEEKLKVTLPH 661
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BLAST of Urocanate hydratase vs. TrEMBL
Match: A0A2C9JCS7 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106054058 PE=3 SV=1)

HSP 1 Score: 834.328 bits (2154), Expect = 0.000e+0
Identity = 395/684 (57.75%), Postives = 511/684 (74.71%), Query Frame = 2 
Query:  104 VDLNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPN 2155
            + L  L  G+PL PLPE      + PHA +    LT  ++KL+V+NAL+YFP   HE L +EF  EL TYGHIYMYRF+P  + +RAY I  YPAK T AAAIM MI NNLDP +AQ+P ELVTYGGNGQVFSNWAQ+W+ M +LS+M   QTLVMYSGHP+GLFP+  +  SP++VI+NGM++PNYSS   Y+KLF+LGV+ YGQMTAGSYCYIGPQGIVHGT+LT++NA R   K+          KVFV++GLGGMSGAQAKA+VI  C+GV+AEVS+ AL KR++QGWV ++ N +  ++  +++  +  KP SIG +GN+VD+WE LV  ++STGE+L D+GSDQTSCH   +GGYYP  +S++++R +M+QD   FK LV ESL +QV AIN LS  GMYFFDYGNAFLL+A R+GADV   +  H T+     FKYPSYVQDIMG IFS+GFGPFRW+C+S D +DL KTD +A   IE++           NS   +VK QY+DN  WIK A  + +VVGS+ARILY+D +GR+++A AFN+A++   +  P+++SRDHHDVSGTDS +RETSNIYDGSA CADM++QNV+GDSFRGATW+A+HNGGG GWGE +NGGFGL+LDGS+EA  ++ +ML WDV NG+SRR W+GN+ A+ T++R  +    L +  P+
Sbjct:    2 LTLKELCGGLPLDPLPELQPRDPNVPHAPIRVQELTREEEKLAVQNALRYFPARFHELLAQEFAIELRTYGHIYMYRFRPDID-MRAYPITDYPAKCTSAAAIMHMIMNNLDPKVAQFPHELVTYGGNGQVFSNWAQFWLTMHYLSEMSETQTLVMYSGHPMGLFPS--MTTSPRLVITNGMMIPNYSSREMYDKLFSLGVTMYGQMTAGSYCYIGPQGIVHGTTLTILNAARKNLKTNDLAG-----KVFVSAGLGGMSGAQAKAAVICGCVGVVAEVSEDALLKRYNQGWVMELVNDLDNLVALLKNARRRKKPLSIGYHGNIVDVWERLVMEYESTGEVLVDLGSDQTSCHNPFQGGYYPVQISHQEAREMMHQDPVNFKVLVQESLCRQVAAINKLSAGGMYFFDYGNAFLLEASRAGADVGRKDGLHGTT-----FKYPSYVQDIMGDIFSLGFGPFRWVCTSADPEDLKKTDALALSVIEQL---------SKNSIPCSVKQQYDDNAKWIKEAGEHNMVVGSQARILYSDQDGRISVALAFNKAVSEGYLKGPVVISRDHHDVSGTDSLYRETSNIYDGSAFCADMSVQNVLGDSFRGATWIALHNGGGVGWGEVMNGGFGLVLDGSEEAKTRAENMLAWDVSNGVSRRCWAGNQNAKETIQRTMMTEPRLRVTLPH 663
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BLAST of Urocanate hydratase vs. TrEMBL
Match: V3ZRU4 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_222456 PE=3 SV=1)

HSP 1 Score: 833.558 bits (2152), Expect = 0.000e+0
Identity = 407/683 (59.59%), Postives = 513/683 (75.11%), Query Frame = 2 
Query:  128 GIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY*NRNLF 2176
            G+PL PLP       S PHA V N GLT  +++L+++N+L+YFP  +HE L  EF  EL  YGHIYMYRF+P  E +RAY I+ YPA+  +AAA+M MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+ ++M++LS M  +QTLVMYSGHP+GLFP+ P   SP++VI+NGMVVPNYSS   Y+KLFALG + YGQMTAGSYCYIGPQGIVHGT+LT++NA R    +G         KVFVTSGLGGMSGAQAKA+VI+ C+GVIAEVSK A+ KR++QGW++++ +++ E +  I+ H  +  PTSIG +GNVVDLWE L D + STGELL D+GSDQTSCH    GGYYP  LSYE +R +M+ D  +FK LV ESLR+ ++AIN L+ +GM+F+DYGNAFLL+A R+GADV  +   ++ S     F+YPSYVQDIMG IFS+GFGPFRW+C+S    DL K+DEIAA  +E I+     E++K          QY DN+ WIK A N+ +VVGS+ARILY++  GR  IA AFN+AIA+  +SAPI +SRDHHDVSGTDSPFRETSNI DGS++CADMAIQNVIGDSFRGATWVAIHNGGG GWGE INGGFGL+LDGS++AG ++  ML WDV NG++RR WSGN  A  T+ R   +  +L++  P + +  L 
Sbjct:   10 GLPLNPLPLQKPRDESVPHAPVLNPGLTQGEQRLALENSLRYFPPEVHEVLAPEFLEELNQYGHIYMYRFRPYIE-MRAYPINEYPAQTRQAAAVMHMIMNNLDPHVAQFPQELVTYGGNGQVFSNWAQFLLMMRYLSIMTEEQTLVMYSGHPMGLFPSTP--ESPRVVITNGMVVPNYSSRDLYDKLFALGTTMYGQMTAGSYCYIGPQGIVHGTTLTILNAARKHLNTGDLSG-----KVFVTSGLGGMSGAQAKAAVISGCVGVIAEVSKEAIYKRYNQGWLQEVTDNLNECMLMIKHHRHNKTPTSIGYHGNVVDLWERLADEYDSTGELLVDLGSDQTSCHNPFLGGYYPVQLSYEDAREVMSSDPIRFKNLVQESLRRHISAINRLATRGMFFWDYGNAFLLEASRAGADVGREEGVNSAS-----FRYPSYVQDIMGDIFSLGFGPFRWVCTSGLSSDLEKSDEIAASVLEDIIKQGVPESTKQ---------QYTDNIRWIKEAGNHKMVVGSQARILYSNQLGRQAIALAFNKAIADGEISAPIAISRDHHDVSGTDSPFRETSNITDGSSLCADMAIQNVIGDSFRGATWVAIHNGGGVGWGEVINGGFGLVLDGSQDAGRRAKLMLGWDVNNGVARRCWSGNLKAEETICRAMDEDSSLKITVPYHADSRLL 670
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BLAST of Urocanate hydratase vs. Ensembl Cavefish
Match: uroc1 (urocanate hydratase 1 [Source:NCBI gene;Acc:103023404])

HSP 1 Score: 798.119 bits (2060), Expect = 0.000e+0
Identity = 384/646 (59.44%), Postives = 479/646 (74.15%), Query Frame = 2 
Query:  173 SYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTME 2110
            S PHA V    LT  +++L++KNAL+YFP +LH  L  EF  EL  YGHIYMYRF P    +RAY ID YP KI  AAAIM MI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+W+V  +LS M  +QTLVMYSGHPLGLFP+ P  +SP+ VI+NGMV+PNYSS   YEK+FALG++ YGQMTAGSYCYIGPQGIVHGT LT++NA R    +     +  R +VFVTSGLGGMSGAQAKA+VIA C+GVIAEV +  L+KR  QGW+ ++   +   +++IR+  +S    S+G +GN+VDLWE L   ++ TGELL D+GSDQTS H    GGYYP  LS++++  LMN D   FK  VHESL + V AIN LS +GMYF+DYGNAFLL+A R+GA+V        +     +FKYPSYVQ IMG IFS+GFGPFRW+C+S D  DL  TD IA   +E+I +          S    V+ QY DN+ WI+ A  + +VVGS+ARILY+D +GRV+IA A N+A+++  V AP+++SRDHHDVSGTDSPFRETSNIYDGSA CADMA+QNVIGDSFRGATWVA+HNGGG GWGE +NGGFGL+LDGS++AG+++ +ML WDV NG++RR WSGN  A  T++
Sbjct:   25 SMPHAPVRTPNLTAEEERLALKNALRYFPPDLHSTLAPEFAQELRQYGHIYMYRFCPTVR-MRAYPIDQYPCKIRHAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLVFHYLSTMSEEQTLVMYSGHPLGLFPSLP--SSPRCVITNGMVIPNYSSRESYEKMFALGITMYGQMTAGSYCYIGPQGIVHGTMLTVLNAGRRYLGT-----SDLRGRVFVTSGLGGMSGAQAKAAVIAGCVGVIAEVDEVPLKKRHEQGWLMEVTKDLDHCMKRIREARRSQMALSLGYHGNIVDLWERLWQEYERTGELLVDLGSDQTSLHNPFSGGYYPVQLSFKQANHLMNTDPQLFKTTVHESLCRHVAAINKLSEEGMYFWDYGNAFLLEAKRAGAEV------EKSGAGATEFKYPSYVQHIMGDIFSLGFGPFRWVCTSGDPADLATTDGIATAVLEEISA----------SVTELVRQQYNDNICWIREAGKHNMVVGSQARILYSDQKGRVSIALAINKAVSDGRVKAPVVISRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNVIGDSFRGATWVALHNGGGVGWGEVMNGGFGLVLDGSEDAGKRARTMLNWDVSNGVARRCWSGNSNAHETIQ 646
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BLAST of Urocanate hydratase vs. Ensembl Nematostella
Match: EDO46925 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNH9])

HSP 1 Score: 806.594 bits (2082), Expect = 0.000e+0
Identity = 392/677 (57.90%), Postives = 491/677 (72.53%), Query Frame = 2 
Query:  110 LNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLE 2140
            L  L  G+P+ P+PE      S PHA V    L+  ++ L+++NAL+YFP  +HE L  EF  EL  YGHIYMYRF+P  + +RAY ID YPA+  +AAAIM MI NNLDP +AQ+P ELVTYGGNGQVFSNWAQ+WIVM++LS+MK DQTLVMYSGHP GLFP++ +  +P++VI+NGM++PNYS+   Y+KLFALG + YGQMTAGSYCYIGPQGIVHGT++ ++NA R   KS          KVFVTSGLGGMSGAQ KA VIA CI V+AE+++ AL KR+ QGW+ +  + +P  IE+I+   K  KP SIG  GNVV LWEAL D +  TGELL D GSDQTS H    GGYYP  +S++++  +M  D ++FK LV +SL +QV AIN L  +GM+F+DYGNAFLL+A R+GA V  +     T      F +PSYVQDIMG +F MGFGPFRW+C+S    DL  TDEIA + +E I+S    +          VK+QY DN+ WIK AQ + LVVGS+ARILY D  GRV IA+AFN+AIA K +S  ++LSRDHHDVSGTDSPFRETS++YDGS++CADMAIQNVIGDSFRGATWVAIHNGGG GWGE INGGFG++LDGS+E  +++  ML WDV NG+ RR W+GNE A   +      C+++E
Sbjct:    4 LKDLCAGLPVDPIPEPRDRDESVPHAPVRLTHLSEDEELLALQNALRYFPPEIHEVLAPEFAQELRDYGHIYMYRFRPDLD-MRAYPIDEYPAQTHQAAAIMHMIMNNLDPRVAQFPHELVTYGGNGQVFSNWAQFWIVMQYLSEMKEDQTLVMYSGHPAGLFPSSSM--APRVVITNGMMIPNYSTREMYDKLFALGATMYGQMTAGSYCYIGPQGIVHGTTIVVMNAGRKHLKSDNLAG-----KVFVTSGLGGMSGAQPKAGVIAGCIAVVAEINEAALMKRYEQGWLMEYTSDLPTCIERIKQARKERKPLSIGYLGNVVALWEALADEYDRTGELLVDFGSDQTSLHNPYNGGYYPVQVSFDEANEIMKDDPERFKNLVQQSLLRQVAAINRLHTRGMFFWDYGNAFLLEASRAGAPVVKEGCLPGT------FIHPSYVQDIMGDVFGMGFGPFRWVCTSGLAADLEATDEIAREVLEGIISQGVPDE---------VKVQYNDNMRWIKEAQAHHLVVGSQARILYADRRGRVAIAQAFNKAIAEKRISGCVVLSRDHHDVSGTDSPFRETSSVYDGSSLCADMAIQNVIGDSFRGATWVAIHNGGGVGWGEVINGGFGMVLDGSEEMSQRAEVMLSWDVSNGVYRRAWAGNEKAEHAI------CRDME 651
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BLAST of Urocanate hydratase vs. Ensembl Nematostella
Match: EDO27962 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7T6])

HSP 1 Score: 119.398 bits (298), Expect = 4.624e-32
Identity = 59/99 (59.60%), Postives = 72/99 (72.73%), Query Frame = 2 
Query: 1880 MAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY*NRNLF 2176
            MAIQNVIGDSFRGATWV+IHNGGG GWGE INGGFG++LDG+KEA  +  SML WDV NG+SRR W+ NE A   ++R       L++  PN  + +L 
Sbjct:    1 MAIQNVIGDSFRGATWVSIHNGGGVGWGEVINGGFGMVLDGTKEASRRLESMLFWDVNNGISRRSWARNEGAIFAIKRAMETQPLLKVTIPNIVDESLL 99
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BLAST of Urocanate hydratase vs. Ensembl Nematostella
Match: EDO26503 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TBV0])

HSP 1 Score: 88.5817 bits (218), Expect = 1.563e-21
Identity = 41/80 (51.25%), Postives = 55/80 (68.75%), Query Frame = 2 
Query: 1091 EALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFD 1330
            EAL D +  TGELL D GSDQTS H    GGYYP  +S++++  +M  D ++FK LV +SL +QV AIN L  +GM+F+D
Sbjct:    1 EALADEYDRTGELLVDFGSDQTSLHNPYNGGYYPVQVSFDEANEIMKDDPERFKNLVQQSLLRQVAAINRLHTRGMFFWD 80
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BLAST of Urocanate hydratase vs. Ensembl Medaka
Match: uroc1 (urocanate hydratase 1 [Source:NCBI gene;Acc:101174658])

HSP 1 Score: 813.913 bits (2101), Expect = 0.000e+0
Identity = 390/675 (57.78%), Postives = 498/675 (73.78%), Query Frame = 2 
Query:  128 GIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYP 2152
            G+PL PLP N G   S PHA +    LT  +++L+++NAL+YFP + H  L  EF  EL+ YGHIYMYRF P    LRAY ID YP +  +AAAIMLMI NNLDP +AQ+P+ELVTYGGNGQVFSNWAQ+ +VM +LSQM   QTLVMYSGHP+GLFP+ P  +SP+ +I+NGMV+PNYSS   YEK+FALGVS YGQMTAGSYCYIGPQGIVHGT LT++NA R    +        R +VFVTSGLGGMSGAQAKA+VIA C+GVIAEV +  L KR  QGW+ ++ +S+ + I++IR+   S  P S+G +GN+VDLWE L+   + TGELL D+GSDQTS H    GGYYP  LS+ ++  LM+ D  +F++ V ESLR+Q+ AIN L++ GM+F+DYGNAFLL+A R+GA+V              +F+YPSYVQ IMG IFS+GFGPFRW+C+S D KDL  TD++AA  +EKI +N              ++ QY DN+ WI+ A  + +VVGS+ARILY+D  GR++IA A N+AIA+  VSAP+++SRDHHDVSGTDSPFRETSN+YDGSA CADMA+QN +GD+FRGATWV++HNGGG GWGE INGGFGL+LDGS++A  +++ ML WDV NG++RR WSGN  A  T++R   + K L++  P
Sbjct:   10 GLPLNPLPPNRGRDPSVPHAPIRTPNLTAEEERLALRNALRYFPPSHHATLAPEFAQELQQYGHIYMYRFCPSFP-LRAYPIDQYPCRTRQAAAIMLMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFSLVMHYLSQMTEQQTLVMYSGHPMGLFPSLP--SSPRAIITNGMVIPNYSSRDQYEKMFALGVSMYGQMTAGSYCYIGPQGIVHGTMLTVLNAGRRYLGT-----DDLRGRVFVTSGLGGMSGAQAKAAVIAGCVGVIAEVDEAPLIKRHKQGWLMEVTSSLDQCIKRIREVRSSKTPLSLGYHGNIVDLWERLLLEFERTGELLVDLGSDQTSLHNPFNGGYYPVPLSFHQANQLMSSDPARFRSSVKESLRRQIRAINKLADAGMFFWDYGNAFLLEAKRAGAEV------EKGDGGATEFRYPSYVQHIMGDIFSLGFGPFRWVCTSGDPKDLAVTDDLAASVLEKICAN----------VSDRIRQQYNDNIRWIREAGKHQMVVGSQARILYSDQRGRISIALAINQAIADGKVSAPVVISRDHHDVSGTDSPFRETSNVYDGSAFCADMAVQNFVGDAFRGATWVSLHNGGGVGWGEVINGGFGLVLDGSEDAANRASLMLSWDVSNGVARRCWSGNLNAFETIQRTMKENKQLQVTMP 660
[Close]
BLAST of Urocanate hydratase vs. Planmine SMEST
Match: SMESG000032396.1 (SMESG000032396.1)

HSP 1 Score: 1425.22 bits (3688), Expect = 0.000e+0
Identity = 684/687 (99.56%), Postives = 685/687 (99.71%), Query Frame = 2 
Query:   98 MGVDLNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY 2158
            MGVDLNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDK LSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGL YEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKS+SMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY
Sbjct:    1 MGVDLNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKILSVKNALKYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKITEAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQMKSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFALGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERIKVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIANSIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGSDQTSCHILLEGGYYPAGLPYEKSRILMNQDKDKFKALVHESLRKQVNAINYLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQDIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSKDNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAFNEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNVIGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSSSMLEWDVINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY 687
The following BLAST results are available for this feature:
BLAST of Urocanate hydratase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
UROC10.000e+058.56urocanate hydratase 1 [Source:HGNC Symbol;Acc:HGNC... [more]
UROC12.785e-14057.42urocanate hydratase 1 [Source:HGNC Symbol;Acc:HGNC... [more]
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BLAST of Urocanate hydratase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Y51H4A.70.000e+053.36Probable urocanate hydratase [Source:UniProtKB/Sw... [more]
Y51H4A.70.000e+053.36Probable urocanate hydratase [Source:UniProtKB/Sw... [more]
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BLAST of Urocanate hydratase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Urocanate hydratase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
uroc10.000e+058.83urocanate hydratase 1 [Source:ZFIN;Acc:ZDB-GENE-08... [more]
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BLAST of Urocanate hydratase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
p4ha20.000e+055.00prolyl 4-hydroxylase, alpha polypeptide 2 [Source:... [more]
p4ha20.000e+058.60prolyl 4-hydroxylase, alpha polypeptide 2 [Source:... [more]
p4ha20.000e+054.69prolyl 4-hydroxylase, alpha polypeptide 2 [Source:... [more]
p4ha20.000e+054.25prolyl 4-hydroxylase, alpha polypeptide 2 [Source:... [more]
p4ha20.000e+052.10prolyl 4-hydroxylase, alpha polypeptide 2 [Source:... [more]
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BLAST of Urocanate hydratase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Uroc10.000e+058.91urocanase domain containing 1 [Source:MGI Symbol;A... [more]
Uroc10.000e+056.32urocanase domain containing 1 [Source:MGI Symbol;A... [more]
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BLAST of Urocanate hydratase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q96N76|HUTU_HUMAN0.000e+058.56Urocanate hydratase OS=Homo sapiens OX=9606 GN=URO... [more]
sp|Q8VC12|HUTU_MOUSE0.000e+058.91Urocanate hydratase OS=Mus musculus OX=10090 GN=Ur... [more]
sp|Q86AX3|HUTU_DICDI0.000e+055.11Probable urocanate hydratase OS=Dictyostelium disc... [more]
sp|Q9NAE2|HUTU_CAEEL0.000e+053.36Probable urocanate hydratase OS=Caenorhabditis ele... [more]
sp|Q978N4|HUTU_THEVO1.458e-10134.44Probable urocanate hydratase OS=Thermoplasma volca... [more]
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BLAST of Urocanate hydratase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A433TFY80.000e+058.70Uncharacterized protein OS=Elysia chlorotica OX=18... [more]
A0A3S4QGW70.000e+061.60Urocanate hydratase-like isoform X1 OS=Dinothrombi... [more]
G1KP640.000e+059.76Urocanate hydratase 1 OS=Anolis carolinensis OX=28... [more]
A0A2C9JCS70.000e+057.75Uncharacterized protein OS=Biomphalaria glabrata O... [more]
V3ZRU40.000e+059.59Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
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BLAST of Urocanate hydratase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
uroc10.000e+059.44urocanate hydratase 1 [Source:NCBI gene;Acc:103023... [more]
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BLAST of Urocanate hydratase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Urocanate hydratase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Urocanate hydratase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO469250.000e+057.90Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO279624.624e-3259.60Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO265031.563e-2151.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Urocanate hydratase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
uroc10.000e+057.78urocanate hydratase 1 [Source:NCBI gene;Acc:101174... [more]
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BLAST of Urocanate hydratase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000032396.10.000e+099.56SMESG000032396.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002510 ID=SMED30002510|Name=Urocanate hydratase|organism=Schmidtea mediterranea sexual|type=transcript|length=2234bp
TTAATAGTAAGTAGATTAAATCGTTAAATTACTTGAACTCTAACCTATAA
GTTATGATAAATAAAACATTAGTTATTCGTGAAATTATTTCAATTTTATG
GGTGTCGACTTGAATATTTTGTCTTTGGGAATACCCTTAGTACCCTTACC
AGAAAACAATGGACCAAGCAGCTCGTATCCTCACGCTCAAGTTCACAATC
ATGGTTTGACAAATTCTGATAAGAAATTGTCTGTGAAAAATGCTTTAAAA
TACTTTCCGAAAAATTTACATGAAAGATTAGGAAAAGAATTTGAAACAGA
ATTGGAAACTTATGGCCATATCTATATGTATCGTTTTAAACCACCCAGAG
AAGTTTTGAGAGCGTATCATATAGATATGTATCCAGCAAAGATAACTGAA
GCTGCTGCAATTATGTTGATGATTTCAAATAATCTTGATCCAGACATTGC
TCAATACCCGGAGGAATTAGTTACTTATGGTGGAAATGGTCAAGTTTTCT
CTAACTGGGCCCAGTATTGGATTGTTATGAAATTTTTGTCTCAAATGAAA
TCTGATCAAACTTTAGTAATGTATTCAGGTCATCCTTTAGGTCTATTTCC
GACAAATCCATTATACAACAGTCCAAAAATGGTCATTAGCAATGGTATGG
TAGTTCCTAATTATTCATCTCCAGCAGATTATGAAAAGCTTTTTGCACTG
GGTGTAAGCCAGTATGGACAAATGACAGCAGGAAGTTATTGTTACATCGG
ACCCCAAGGAATAGTTCATGGAACGTCATTAACACTTATCAATGCTATAC
GGAATCAAAAGAAAAGTGGGGGAAAATGTAATACTAGTGAAAGAATAAAA
GTCTTTGTAACTTCCGGTCTTGGCGGAATGAGTGGAGCTCAGGCCAAAGC
ATCAGTAATAGCCAATTGTATTGGTGTAATTGCCGAGGTATCTAAGACCG
CTCTTCAGAAAAGGTTTAGCCAAGGGTGGGTTGAGCAAATCGCAAATTCT
ATACCTGAAGTCATAGAAAAAATACGAGATCATATGAAGTCCAATAAACC
TACTAGTATTGGATTATATGGAAATGTTGTTGATTTATGGGAGGCGCTAG
TTGACCACCATAAATCAACTGGTGAATTACTTGCGGATATAGGATCAGAT
CAAACTTCTTGCCATATTCTTCTTGAAGGTGGATATTATCCAGCAGGTTT
ATCGTATGAAAAATCTCGGATTTTAATGAACCAGGACAAAGACAAGTTTA
AAGCATTGGTGCATGAAAGTCTGAGAAAACAAGTTAACGCAATAAACTAT
TTATCCAACAAAGGAATGTACTTTTTTGATTATGGAAATGCCTTTCTTTT
GCAAGCTGGCAGGTCTGGAGCGGATGTATTTGTCGATAACCAAACTCACA
ATACTAGCACAGTTCAAAATAAATTCAAATATCCCTCCTATGTTCAGGAC
ATAATGGGTCAAATATTTTCTATGGGTTTCGGGCCGTTTAGATGGATTTG
TAGTTCATGTGACGAGAAGGATTTAGTTAAGACAGATGAAATCGCGGCTA
AGGAAATTGAAAAGATTTTAAGCAATGAGTACTTTGAGAATTCCAAAGAT
AACTCCTACAAATTGAATGTCAAATTACAATATGAAGATAATTTAAGTTG
GATTAAAAATGCACAAAATTACGGTCTAGTTGTGGGATCAAAGGCGAGAA
TTCTTTATACTGATGCTGAAGGAAGAGTTAATATTGCAAGAGCATTTAAT
GAGGCTATAGCAAATAAAATAGTTAGTGCTCCAATAATTTTAAGTAGAGA
TCACCATGATGTCAGTGGAACTGACAGTCCTTTCAGAGAAACTTCCAACA
TTTACGACGGATCGGCTGTCTGTGCTGATATGGCGATACAAAACGTTATT
GGAGACTCTTTTCGAGGAGCAACTTGGGTAGCTATTCATAACGGTGGTGG
AACTGGCTGGGGAGAAGCAATAAATGGTGGATTCGGTCTTTTACTGGATG
GCTCCAAAGAAGCAGGAGAAAAATCGGCATCGATGTTAGAATGGGACGTA
ATTAATGGATTATCAAGAAGAATGTGGTCTGGTAATGAAACTGCTCGAAG
CACAATGGAAAGACTAAATTTGAAATGCAAAAATTTAGAATTATTTTATC
CCAATTACTAAAATAGGAATTTATTTATTTTAGTTAATAAATGAAGTCTG
AAAAATGGCAAAAATTATTGAAAAATAGTAAAAG
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protein sequence of SMED30002510-orf-1

>SMED30002510-orf-1 ID=SMED30002510-orf-1|Name=SMED30002510-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=688bp
MGVDLNILSLGIPLVPLPENNGPSSSYPHAQVHNHGLTNSDKKLSVKNAL
KYFPKNLHERLGKEFETELETYGHIYMYRFKPPREVLRAYHIDMYPAKIT
EAAAIMLMISNNLDPDIAQYPEELVTYGGNGQVFSNWAQYWIVMKFLSQM
KSDQTLVMYSGHPLGLFPTNPLYNSPKMVISNGMVVPNYSSPADYEKLFA
LGVSQYGQMTAGSYCYIGPQGIVHGTSLTLINAIRNQKKSGGKCNTSERI
KVFVTSGLGGMSGAQAKASVIANCIGVIAEVSKTALQKRFSQGWVEQIAN
SIPEVIEKIRDHMKSNKPTSIGLYGNVVDLWEALVDHHKSTGELLADIGS
DQTSCHILLEGGYYPAGLSYEKSRILMNQDKDKFKALVHESLRKQVNAIN
YLSNKGMYFFDYGNAFLLQAGRSGADVFVDNQTHNTSTVQNKFKYPSYVQ
DIMGQIFSMGFGPFRWICSSCDEKDLVKTDEIAAKEIEKILSNEYFENSK
DNSYKLNVKLQYEDNLSWIKNAQNYGLVVGSKARILYTDAEGRVNIARAF
NEAIANKIVSAPIILSRDHHDVSGTDSPFRETSNIYDGSAVCADMAIQNV
IGDSFRGATWVAIHNGGGTGWGEAINGGFGLLLDGSKEAGEKSASMLEWD
VINGLSRRMWSGNETARSTMERLNLKCKNLELFYPNY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000421tail
Vocabulary: INTERPRO
TermDefinition
IPR035401Urocanase_C
IPR038364Urocanase_central_sf
IPR035085Urocanase_Rossmann-like
IPR035400Urocanase_N
IPR036190Urocanase_sf
IPR023637Urocanase
IPR023636Urocanase_CS
Vocabulary: molecular function
TermDefinition
GO:0016153urocanate hydratase activity
GO:0016829lyase activity
Vocabulary: cellular component
TermDefinition
GO:0005829cytosol
Vocabulary: biological process
TermDefinition
GO:0006547histidine metabolic process
GO:0006548histidine catabolic process
GO:0019556histidine catabolic process to glutamate and formamide
GO:0019557histidine catabolic process to glutamate and formate
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:3.40.1770.10coord: 95..667
e-value: 1.0E-213
score: 712.3
NoneNo IPR availablePANTHERPTHR12216:SF3UROCANATE HYDRATASEcoord: 6..685
IPR035401Urocanase, C-terminal domainPFAMPF17392Urocanase_Ccoord: 456..671
e-value: 6.1E-80
score: 267.3
IPR038364Urocanase, central domain superfamilyGENE3DG3DSA:3.40.50.10730coord: 219..452
e-value: 1.0E-213
score: 712.3
IPR035085Urocanase, Rossmann-like domainPFAMPF01175Urocanasecoord: 218..452
e-value: 5.8E-74
score: 248.3
IPR023637UrocanasePIRSFPIRSF001423Urocanate_hydratcoord: 71..683
e-value: 1.1E-190
score: 632.2
IPR023637UrocanasePANTHERPTHR12216FAMILY NOT NAMEDcoord: 6..685
IPR035400Urocanase, N-terminal domainPFAMPF17391Urocanase_Ncoord: 87..215
e-value: 3.4E-51
score: 172.2
IPR023636Urocanase conserved sitePROSITEPS01233UROCANASEcoord: 567..582
IPR036190Urocanase superfamilySUPERFAMILYSSF111326Urocanasecoord: 87..676