Angiotensin-converting enzyme
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002442 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Angiotensin-converting enzyme vs. Ensembl Human
Match: ACE (angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707]) HSP 1 Score: 349.747 bits (896), Expect = 8.914e-110 Identity = 195/564 (34.57%), Postives = 300/564 (53.19%), Query Frame = 2
Query: 272 NRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR+FVS +++FQF E+LC+ PLH C +YQSK G L MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 91 NEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 647
BLAST of Angiotensin-converting enzyme vs. Ensembl Human
Match: AC113554.1 (novel protein) HSP 1 Score: 349.362 bits (895), Expect = 1.504e-109 Identity = 195/564 (34.57%), Postives = 300/564 (53.19%), Query Frame = 2
Query: 272 NRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR+FVS +++FQF E+LC+ PLH C +YQSK G L MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 91 NEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 647
BLAST of Angiotensin-converting enzyme vs. Ensembl Human
Match: ACE (angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707]) HSP 1 Score: 352.443 bits (903), Expect = 1.545e-106 Identity = 198/602 (32.89%), Postives = 323/602 (53.65%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF--P-WQQFHSKKMREMFEIITTSVKSVDPEVFKRII--KIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + D ++ A+++ +++ ++ + + TNIT++N + + ++ AK P WQ F ++R + + T + S + + KR + + + IY+ A+ C TC S + + N+ + ++Y LL W W G+ ++ LY D L +A K++G + ++ + F + L L+ + P+Y LHA+VR L Y DR+ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + + + M EFWE S+ KP D R V CH+S+ DF N DFR+K C++ T+ S +HHEMGHIQY++ Y+ LP+ R AN F E IGD +ALS+ T L KIGLL + + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+H+ PYIR+FVS +L+FQF E+LC+ PLH C +Y+S G+ L ++++ G +PW+E++K + + + + LL++F P+TQWL + N+ +GW
Sbjct: 34 LQPGNFSADEAGAQLFAQSYNSSAEQVLFQS----VAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRT-LGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSL-DPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAY-WRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGW 623 HSP 2 Score: 350.903 bits (899), Expect = 5.023e-106 Identity = 205/617 (33.23%), Postives = 319/617 (51.70%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ N + + + W PL + YP D E A ++ + + N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR+FVS +++FQF E+LC+ PLH C +YQSK G L MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 612 EQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 1221
BLAST of Angiotensin-converting enzyme vs. Ensembl Human
Match: ACE (angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707]) HSP 1 Score: 352.829 bits (904), Expect = 2.785e-106 Identity = 198/602 (32.89%), Postives = 323/602 (53.65%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF--P-WQQFHSKKMREMFEIITTSVKSVDPEVFKRII--KIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + D ++ A+++ +++ ++ + + TNIT++N + + ++ AK P WQ F ++R + + T + S + + KR + + + IY+ A+ C TC S + + N+ + ++Y LL W W G+ ++ LY D L +A K++G + ++ + F + L L+ + P+Y LHA+VR L Y DR+ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + + + M EFWE S+ KP D R V CH+S+ DF N DFR+K C++ T+ S +HHEMGHIQY++ Y+ LP+ R AN F E IGD +ALS+ T L KIGLL + + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+H+ PYIR+FVS +L+FQF E+LC+ PLH C +Y+S G+ L ++++ G +PW+E++K + + + + LL++F P+TQWL + N+ +GW
Sbjct: 34 LQPGNFSADEAGAQLFAQSYNSSAEQVLFQS----VAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRT-LGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSL-DPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAY-WRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGW 623 HSP 2 Score: 351.288 bits (900), Expect = 9.841e-106 Identity = 205/617 (33.23%), Postives = 319/617 (51.70%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ N + + + W PL + YP D E A ++ + + N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR+FVS +++FQF E+LC+ PLH C +YQSK G L MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 612 EQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 1221
BLAST of Angiotensin-converting enzyme vs. Ensembl Human
Match: ACE (angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707]) HSP 1 Score: 288.886 bits (738), Expect = 4.959e-87 Identity = 176/564 (31.21%), Postives = 274/564 (48.58%), Query Frame = 2
Query: 272 NRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 91 NEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIR-----------------------------------------TAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 606
BLAST of Angiotensin-converting enzyme vs. Ensembl Celegans
Match: acn-1 (Inactive angiotensin-converting enzyme-related protein [Source:UniProtKB/Swiss-Prot;Acc:Q18581]) HSP 1 Score: 151.369 bits (381), Expect = 7.844e-38 Identity = 143/625 (22.88%), Postives = 262/625 (41.92%), Query Frame = 2
Query: 155 VFDSFYWLTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKK-MREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTC---LSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNI-----ASFKMFEDFQEENFL--ETLMKLFDNVMPIYKQLHAYVRYCLAEYY--PDRFNKTGPIPAHILGDV----WAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSE-DFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSS------LEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDP-----GSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
V S YW T P S E +WL I+ +A +RY + + + L++ + + AK F +K MR++ + + ++ P F + + + + C K + + + ++F EK+ L W+ + + + Y + + + AK NG N ++F M + F + + K++ + P Y+ LHAY+R LA Y P +K GPIPAH+ G + W+ ++ P ++ F+ N+ KM F T + G + +W S+F + + + CH ++ D DFRVK C++ F H + Y Y+ +L+R A+ +I D +A + LS+ +K+ ++ + I+ L +LE+ +PF + + L++G+VP +++N WW++ + Y+G++ P N D S+ H P R +S +LKFQ ++LC + C L S++ L E MK G W + +++I+ ++ + LL ++ PL WL TN++ + VGW
Sbjct: 158 VNSSNYWKTDNLQAPGSIKDEEKLRSWLAGYEAEAIKVLREVALSGWRYFNDASPSLKLALDEAENVLTMFVRSTSMQAKQFDMASVTDEKVMRQLGYVSFEGMSALAPSRFADYSQAQAALNRDSKDSTICDKDVPPPCALQKIDMDSIFRNEKDASRLQHLWVSYVTAI-AKSKPSYNNIITISNEGAKLNGFANGGAMWRSAFDMSSKVHKAEFDLNKQIDKIYSTIQPFYQLLHAYMRRQLAGIYSNPVGLSKDGPIPAHLFGSLDGGDWSAHYEQTKPFEEESETPEAMLSAFNTQNYTTKKM-----FVTAYRYFKSAGFPHLPKSYWTSSIFARVWSKDMICHPAAALDMRAPNDFRVKACAQLGEPDFEQAHSLLVQTYYQYLYKDQSLLFREQASP----VITDAIANAFAHLSTNPHYLYSQKLVPSEHLDIKDSVIINKLYKESLESFTKLPFTIAADNWRYELFDGTVPKNKLNDRWWEIRNKYEGVRSPQPYNTSNLDALIHNSVSQVH----SPATRTLISYVLKFQILKALCPEGTILS--EGCIL--SEDTTEKLRETMKLGSSITWLKALEMISGKGELDAQPLLEYYEPLINWLRNTNEIDQVVVGW 764
BLAST of Angiotensin-converting enzyme vs. Ensembl Celegans
Match: acn-1 (Inactive angiotensin-converting enzyme-related protein [Source:UniProtKB/Swiss-Prot;Acc:Q18581]) HSP 1 Score: 151.369 bits (381), Expect = 7.844e-38 Identity = 143/625 (22.88%), Postives = 262/625 (41.92%), Query Frame = 2
Query: 155 VFDSFYWLTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKK-MREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTC---LSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNI-----ASFKMFEDFQEENFL--ETLMKLFDNVMPIYKQLHAYVRYCLAEYY--PDRFNKTGPIPAHILGDV----WAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSE-DFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSS------LEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDP-----GSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
V S YW T P S E +WL I+ +A +RY + + + L++ + + AK F +K MR++ + + ++ P F + + + + C K + + + ++F EK+ L W+ + + + Y + + + AK NG N ++F M + F + + K++ + P Y+ LHAY+R LA Y P +K GPIPAH+ G + W+ ++ P ++ F+ N+ KM F T + G + +W S+F + + + CH ++ D DFRVK C++ F H + Y Y+ +L+R A+ +I D +A + LS+ +K+ ++ + I+ L +LE+ +PF + + L++G+VP +++N WW++ + Y+G++ P N D S+ H P R +S +LKFQ ++LC + C L S++ L E MK G W + +++I+ ++ + LL ++ PL WL TN++ + VGW
Sbjct: 158 VNSSNYWKTDNLQAPGSIKDEEKLRSWLAGYEAEAIKVLREVALSGWRYFNDASPSLKLALDEAENVLTMFVRSTSMQAKQFDMASVTDEKVMRQLGYVSFEGMSALAPSRFADYSQAQAALNRDSKDSTICDKDVPPPCALQKIDMDSIFRNEKDASRLQHLWVSYVTAI-AKSKPSYNNIITISNEGAKLNGFANGGAMWRSAFDMSSKVHKAEFDLNKQIDKIYSTIQPFYQLLHAYMRRQLAGIYSNPVGLSKDGPIPAHLFGSLDGGDWSAHYEQTKPFEEESETPEAMLSAFNTQNYTTKKM-----FVTAYRYFKSAGFPHLPKSYWTSSIFARVWSKDMICHPAAALDMRAPNDFRVKACAQLGEPDFEQAHSLLVQTYYQYLYKDQSLLFREQASP----VITDAIANAFAHLSTNPHYLYSQKLVPSEHLDIKDSVIINKLYKESLESFTKLPFTIAADNWRYELFDGTVPKNKLNDRWWEIRNKYEGVRSPQPYNTSNLDALIHNSVSQVH----SPATRTLISYVLKFQILKALCPEGTILS--EGCIL--SEDTTEKLRETMKLGSSITWLKALEMISGKGELDAQPLLEYYEPLINWLRNTNEIDQVVVGW 764
BLAST of Angiotensin-converting enzyme vs. Ensembl Fly
Match: Ance (gene:FBgn0012037 transcript:FBtr0080553) HSP 1 Score: 330.872 bits (847), Expect = 4.497e-104 Identity = 179/591 (30.29%), Postives = 312/591 (52.79%), Query Frame = 2
Query: 215 ETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEV-FKRIIKIKNRIEHIYNKARPC-YKT---CLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIE------PLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E A+ +L +N+ + + N + Y +NIT +N N+ K+ + S F W+ + S+ ++ F+ +T + PE + ++ + +E + K + C YK C A + I + + ++++ L YW + + G +R + L +AAK N + A ++++++ F + L +F ++ P+Y+Q+H YVR+ L ++Y D ++TGPIP H+LG++WAQ W I I+ P +V+ ++ K ++F+ + + M + ++ +FW++S+ KP D R + CH+S+ DF D R+K C++ T +HHE+GHIQYF+ YQH P +YR AN F E +GD ++LS+ T LEKIGLL + + + I+ L L AL+ + F+PFA + SL+ G V + N +WKL Y GI+PP+ R+E++FD +KYHI+ + Y+R+ VS +++FQF++S C + + PL C +Y S G+ ++ G KPW + ++ N + ++ +F PL WL N N+H+GW
Sbjct: 22 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAE-AWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF-----PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGW 606
BLAST of Angiotensin-converting enzyme vs. Ensembl Fly
Match: Ance (gene:FBgn0012037 transcript:FBtr0343667) HSP 1 Score: 330.872 bits (847), Expect = 4.497e-104 Identity = 179/591 (30.29%), Postives = 312/591 (52.79%), Query Frame = 2
Query: 215 ETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEV-FKRIIKIKNRIEHIYNKARPC-YKT---CLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIE------PLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E A+ +L +N+ + + N + Y +NIT +N N+ K+ + S F W+ + S+ ++ F+ +T + PE + ++ + +E + K + C YK C A + I + + ++++ L YW + + G +R + L +AAK N + A ++++++ F + L +F ++ P+Y+Q+H YVR+ L ++Y D ++TGPIP H+LG++WAQ W I I+ P +V+ ++ K ++F+ + + M + ++ +FW++S+ KP D R + CH+S+ DF D R+K C++ T +HHE+GHIQYF+ YQH P +YR AN F E +GD ++LS+ T LEKIGLL + + + I+ L L AL+ + F+PFA + SL+ G V + N +WKL Y GI+PP+ R+E++FD +KYHI+ + Y+R+ VS +++FQF++S C + + PL C +Y S G+ ++ G KPW + ++ N + ++ +F PL WL N N+H+GW
Sbjct: 22 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAE-AWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF-----PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGW 606
BLAST of Angiotensin-converting enzyme vs. Ensembl Fly
Match: Ance (gene:FBgn0012037 transcript:FBtr0080552) HSP 1 Score: 330.872 bits (847), Expect = 4.497e-104 Identity = 179/591 (30.29%), Postives = 312/591 (52.79%), Query Frame = 2
Query: 215 ETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEV-FKRIIKIKNRIEHIYNKARPC-YKT---CLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIE------PLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E A+ +L +N+ + + N + Y +NIT +N N+ K+ + S F W+ + S+ ++ F+ +T + PE + ++ + +E + K + C YK C A + I + + ++++ L YW + + G +R + L +AAK N + A ++++++ F + L +F ++ P+Y+Q+H YVR+ L ++Y D ++TGPIP H+LG++WAQ W I I+ P +V+ ++ K ++F+ + + M + ++ +FW++S+ KP D R + CH+S+ DF D R+K C++ T +HHE+GHIQYF+ YQH P +YR AN F E +GD ++LS+ T LEKIGLL + + + I+ L L AL+ + F+PFA + SL+ G V + N +WKL Y GI+PP+ R+E++FD +KYHI+ + Y+R+ VS +++FQF++S C + + PL C +Y S G+ ++ G KPW + ++ N + ++ +F PL WL N N+H+GW
Sbjct: 22 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAE-AWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF-----PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGW 606
BLAST of Angiotensin-converting enzyme vs. Ensembl Fly
Match: Ance-3 (gene:FBgn0032536 transcript:FBtr0343641) HSP 1 Score: 315.079 bits (806), Expect = 8.017e-96 Identity = 167/523 (31.93%), Postives = 283/523 (54.11%), Query Frame = 2
Query: 413 FHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPC-YKTCLSAGESGIVNLFN---TEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ--IFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKI------EPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
F + R++ ++ +V R ++ N + +YN A C Y+ I L + +++D L W+ + ++ G +RD Y ++ + A N + N + + ++ NF + + +++ + P+Y+ LHAYVR L +YY PDR N+ PIP+HILG+++ Q+W N+ I+ P +V ++ + +F+ E + + M + EF+ S+F +P DR V C S+ DF N DFRVK+C+ ++HHEM HIQYF+ Y+HLP ++R AN AF + +GD + LS+ T L+ +GLL +I+YL +A++ V F+PFA+ + +++G+ MN ++W L Y GIKPP+ R+E++FDPG+KYHI IPYI++F S++L+FQ + LC + + +PLH C +Y+ G++L +M G +PW+E+++ R + +L +FAPL +WL + N N +VGW
Sbjct: 277 FDRRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQCDLHYIPQLKDIMAKSRDWDELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEY-WYLAYESGNFRQDMDIVWEQIRPLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLDILIPY-----PGRKLIDVTPRMVEQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLDRRVLCEPSAWDFCNRHDFRVKICTDINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRSLDESSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLRSEKDFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGNILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQENLRTNEYVGW 793
BLAST of Angiotensin-converting enzyme vs. Ensembl Fly
Match: Ance-3 (gene:FBgn0032536 transcript:FBtr0100327) HSP 1 Score: 315.079 bits (806), Expect = 8.017e-96 Identity = 167/523 (31.93%), Postives = 283/523 (54.11%), Query Frame = 2
Query: 413 FHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPC-YKTCLSAGESGIVNLFN---TEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ--IFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKI------EPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
F + R++ ++ +V R ++ N + +YN A C Y+ I L + +++D L W+ + ++ G +RD Y ++ + A N + N + + ++ NF + + +++ + P+Y+ LHAYVR L +YY PDR N+ PIP+HILG+++ Q+W N+ I+ P +V ++ + +F+ E + + M + EF+ S+F +P DR V C S+ DF N DFRVK+C+ ++HHEM HIQYF+ Y+HLP ++R AN AF + +GD + LS+ T L+ +GLL +I+YL +A++ V F+PFA+ + +++G+ MN ++W L Y GIKPP+ R+E++FDPG+KYHI IPYI++F S++L+FQ + LC + + +PLH C +Y+ G++L +M G +PW+E+++ R + +L +FAPL +WL + N N +VGW
Sbjct: 277 FDRRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQCDLHYIPQLKDIMAKSRDWDELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEY-WYLAYESGNFRQDMDIVWEQIRPLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLDILIPY-----PGRKLIDVTPRMVEQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLDRRVLCEPSAWDFCNRHDFRVKICTDINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRSLDESSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLRSEKDFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGNILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQENLRTNEYVGW 793
BLAST of Angiotensin-converting enzyme vs. Ensembl Zebrafish
Match: ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1826]) HSP 1 Score: 351.673 bits (901), Expect = 4.577e-106 Identity = 203/613 (33.12%), Postives = 320/613 (52.20%), Query Frame = 2
Query: 167 FYWLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNIT--------SDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
F W+ P+ E YP+ E A+ +L + N N + Y T+IT NL + N +I ++ A+ + F + ++ + ++ ++ + E + +E +Y+ A C CL + + + ++YD LL W WR +G +IRD Y L AAK NG + +F ++ F + L L+ ++ P+Y +HAYVR L +Y P+R N GPIPAH+LG++WAQ W I ++ NP+ +V+ + ++ ++F+ + + +G+ M EFW +S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH+QYF+ Y+ PI +R AN F E IGD +ALS+ T L+ IGLL + + I++LM +AL+ + F+PF + + +++G + +S N WW L YQG+ PP+ RTE++FDPG+K+HI +PYIR+FVS +++FQF + LC+ PLH C +YQSK G LL ++MK G KPW E +KII + L+ +F PL +WL K N+ +GW
Sbjct: 654 FNWVPPIPEGYPEDIGKITDEMQAKQFLDEYNSTAEEVWNAYTESSWTYNTDITEAHKDNMLQKNLEMANHTKIYGLE--------ARKYDTSDFQDESVKRILSKLSDLERAALSAEDLVEYNNLLASMETLYSVATVCKDKSNCLPL-DPDLNKIMAESRDYDELLFAWQGWRNASGREIRDSYKRYVELANSAAKSNGHTDNGAF-WRSLYETPTFEQDLEALWKDLEPLYLSVHAYVRRALYKKYGPERINLKGPIPAHLLGNMWAQTWSGIMDLV-------NPYPDATQVDATPAMIAQGWTPKRMFEESDRFFTSLGLLPMPPEFWNKSMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTVVTMDDLITVHHEMGHVQYFLQYKDQPISFRDGANPGFHEAIGDVLALSVATPKHLQSIGLLDKVEDNAESTINFLMSIALDKIAFLPFGYLMDQWRWKVFDGRISSSEYNKEWWNLRMKYQGLCPPVPRTEKDFDPGAKFHIPANVPYIRYFVSFVIQFQFHKGLCDAAGHKGPLHNCDIYQSKEAGKLLSDVMKMGFSKPWPEAMKIITGQPKMSVQPLMEYFKPLIEWLEKENEKNGDVLGW 1249 HSP 2 Score: 339.732 bits (870), Expect = 9.899e-102 Identity = 172/496 (34.68%), Postives = 282/496 (56.85%), Query Frame = 2
Query: 470 VDPEVFKRIIKIKNRIEHIYNKAR--PCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSK-MSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
D E++ I+ ++++ IY+ A+ P + C S E + + T ++Y LL W W +GV ++ LY + + +A++ +G ++ + ++ F + L LF + P+Y+ LHA+VR L +YY P N GPIPAH+LG++W+Q W NI+ ++ N N ++K + +F+ E + +G+ +M EFW++S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P+ +R AN F E IGD ++LS+ T L I LL + + +I+YL+ +ALE + F+PF + + S+++G P R N+ WW L YQGI PP RTEE+FD G KYHI PYIR+FVS +L+FQF E LC+ PLH C +Y+S+ G++L +++K G +PW ++++ + + + L+ +F P+T WL + N+ +GW
Sbjct: 165 TDRELYNTIL---SQMDSIYSTAKVCPSPEECWSL-EPELQEIMATSRSYKRLLYAWEGWHNSSGVPLKSLYAEFVKISNKASQMDGFKDTGEY-WRSWYESPTFKQDLENLFKQLEPLYQNLHAFVRRKLYDYYGPKYINLKGPIPAHLLGNMWSQTWNNIYNMMIPFPNRPN----VDVTNTMIAKGYNATHMFRVAEEFFTSLGLLEMPPEFWDKSMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVEYYLQYKDQPVSFRRGANPGFHEAIGDVLSLSVSTPKHLHSIDLLDQLTDDAESDINYLLKMALEKIAFLPFGYLIDQWRWSVFSGETPPDRYNADWWYLRTKYQGICPPTRRTEEHFDAGGKYHIPGNTPYIRYFVSFILQFQFHEKLCKEAGHTGPLHKCDIYKSREAGAVLEKVLKAGSSEPWTQVLQEALGTDKMDATPLMSYFLPVTTWLREQNEKTGETLGW 651
BLAST of Angiotensin-converting enzyme vs. Ensembl Zebrafish
Match: ace2 (angiotensin I converting enzyme 2 [Source:ZFIN;Acc:ZDB-GENE-041114-6]) HSP 1 Score: 282.337 bits (721), Expect = 6.664e-84 Identity = 163/600 (27.17%), Postives = 296/600 (49.33%), Query Frame = 2
Query: 212 SETCAENWLVKVNEIMIRNENRIANVYYRYA-------TNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMR-EMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCY---KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQN-----IASFKMFED----FQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQI--FKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLL-SNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
S C + + E + + + +++ Y+Y T+I+ +N + +Y N + + +P Q ++ ++ ++ ++ P+ + I + + IYN A C T E G+ ++ ++YD L W WR TG+++R LY +L+ +AAK N ++ ++ +D + + +E +++ ++P+YK+LHAYVR L + YP +PAH+LGD+W + W N++P++ P +V+ + + ++I FK E ++ + M M + FW S+F KP +R V CH ++ D N DFR+KMC+K + F +HHEMGH QY MAY++ P L R AN F E +G+ M+LS T S L+ +GLL S+ + ++ +I++L+ AL V +PF + + ++ +P WW++ G+ + R E DP + +H++ +IR+F ++ +FQF E+LC+ PL+ C + S G L +++ G+ W ++ + + S LL +F+ L +WL + N+ N GW
Sbjct: 13 SVACCQTVEDRAREFLNKFDEEASDIMYQYTLASWAYNTDISQENADKEAEAYAIWSEYYNKMSEESNAYPIDQISDPIIKMQLQKLQDKGSGALSPDKASELRNIMSEMSTIYNTATVCKIDDPTDCQTLEPGLESIMAESRDYDERLHVWEGWRVATGMKMRPLYEKYVDLKNEAAKLNNYEDHGDYWRGDYETIDDPKYSYSRDQVIEDARRIYKEILPLYKELHAYVRAKLQDVYPGHIGSDACLPAHLLGDMWGRFWTNLYPLMIPY-----PDRPDIDVSSAMVEQGWDEIRLFKEAEKFFMSVNMPAMFDNFWNNSMFIKPEERDVVCHPTAWDMGNRKDFRIKMCTKVNMDDFLTVHHEMGHNQYQMAYRNHPYLLRDGANEGFHEAVGEIMSLSAATPSHLQSLGLLPSDFKQDYETDINFLLKQALTIVGTLPFTYMLEEWRWQVFKAKIPKDEWMQQWWQMKRELVGVAEAVPRDETYCDPPALFHVSGDYSFIRYFTRTIYQFQFQEALCKAAGHTGPLYKCDITNSTKAGDKLRHMLELGRSMSWTRALEEVAGTTKMDSQPLLHYFSTLMEWLKEENQKNNRVPGW 607
BLAST of Angiotensin-converting enzyme vs. Ensembl Zebrafish
Match: ace2 (angiotensin I converting enzyme 2 [Source:ZFIN;Acc:ZDB-GENE-041114-6]) HSP 1 Score: 282.722 bits (722), Expect = 8.328e-84 Identity = 163/600 (27.17%), Postives = 296/600 (49.33%), Query Frame = 2
Query: 212 SETCAENWLVKVNEIMIRNENRIANVYYRYA-------TNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMR-EMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCY---KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQN-----IASFKMFED----FQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQI--FKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLL-SNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
S C + + E + + + +++ Y+Y T+I+ +N + +Y N + + +P Q ++ ++ ++ ++ P+ + I + + IYN A C T E G+ ++ ++YD L W WR TG+++R LY +L+ +AAK N ++ ++ +D + + +E +++ ++P+YK+LHAYVR L + YP +PAH+LGD+W + W N++P++ P +V+ + + ++I FK E ++ + M M + FW S+F KP +R V CH ++ D N DFR+KMC+K + F +HHEMGH QY MAY++ P L R AN F E +G+ M+LS T S L+ +GLL S+ + ++ +I++L+ AL V +PF + + ++ +P WW++ G+ + R E DP + +H++ +IR+F ++ +FQF E+LC+ PL+ C + S G L +++ G+ W ++ + + S LL +F+ L +WL + N+ N GW
Sbjct: 13 SVACCQTVEDRAREFLNKFDEEASDIMYQYTLASWAYNTDISQENADKEAEAYAIWSEYYNKMSEESNAYPIDQISDPIIKMQLQKLQDKGSGALSPDKASELRNIMSEMSTIYNTATVCKIDDPTDCQTLEPGLESIMAESRDYDERLHVWEGWRVATGMKMRPLYEKYVDLKNEAAKLNNYEDHGDYWRGDYETIDDPKYSYSRDQVIEDARRIYKEILPLYKELHAYVRAKLQDVYPGHIGSDACLPAHLLGDMWGRFWTNLYPLMIPY-----PDRPDIDVSSAMVEQGWDEIRLFKEAEKFFMSVNMPAMFDNFWNNSMFIKPEERDVVCHPTAWDMGNRKDFRIKMCTKVNMDDFLTVHHEMGHNQYQMAYRNHPYLLRDGANEGFHEAVGEIMSLSAATPSHLQSLGLLPSDFKQDYETDINFLLKQALTIVGTLPFTYMLEEWRWQVFKAKIPKDEWMQQWWQMKRELVGVAEAVPRDETYCDPPALFHVSGDYSFIRYFTRTIYQFQFQEALCKAAGHTGPLYKCDITNSTKAGDKLRHMLELGRSMSWTRALEEVAGTTKMDSQPLLHYFSTLMEWLKEENQKNNRVPGW 607
BLAST of Angiotensin-converting enzyme vs. Ensembl Xenopus
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:100144634]) HSP 1 Score: 368.237 bits (944), Expect = 3.880e-118 Identity = 191/511 (37.38%), Postives = 296/511 (57.93%), Query Frame = 2
Query: 428 MREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLET-LMKLFDNVMPIYKQLHAYVRYCLAEYYPD-RFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM--SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
+R++ EI ++ E K +I + +E IY+ A+ C T + + + ++YD LL W WR +G QIR+ Y L +AA+ NG + ++ + + E LE+ + KL+D + P+Y LHAYVR L + Y D R N GPIPAH+LG++WAQ+W NI+ ++ P+ +V+ + + + ++F+ ++ + +G+ M EFW++S+ KP DR V CH+S+ DF N DFR+K C+ + +HHEMGH+QYF+ Y+ PIL+R AN F E IGD +ALS+ T L+ IGLL + + +I+YLM +AL+ + F+PF + + +++G P S N WW L YQG+ PP+ RTE +FDPG+K+HI +PYIR+F+S +++FQF E+LC+ + PLH C +YQS G LL + MK G KPW E ++ I ++ + +LL++F PLT WLIK N +GW
Sbjct: 29 LRKLSEIDKAALSE---EEQKEYNQITSDMETIYSVAKVCKDGNTNCHPLDPDLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAY--WRSWYETPTLESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLV-------PYPNAAQVDATPAMINWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKDREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWNLRLKYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQEGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNGETLGW 527
BLAST of Angiotensin-converting enzyme vs. Ensembl Xenopus
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:100144634]) HSP 1 Score: 376.326 bits (965), Expect = 2.899e-115 Identity = 211/619 (34.09%), Postives = 337/619 (54.44%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLET-LMKLFDNVMPIYKQLHAYVRYCLAEYYPD-RFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ + N++ + F W P+ + YP + +E A+ +L + N + Y TNIT N L ++ + L A+ + + F + + + ++ K+ + E K +I + +E IY+ A+ C T + + + ++YD LL W WR +G QIR+ Y L +AA+ NG + ++ + + E LE+ + KL+D + P+Y LHAYVR L + Y D R N GPIPAH+LG++WAQ+W NI+ ++ P+ +V+ + ++ N ++F+ ++ + +G+ M EFW++S+ KP DR V CH+S+ DF N DFR+K C+ + +HHEMGH+QYF+ Y+ PIL+R AN F E IGD +ALS+ T L+ IGLL + + +I+YLM +AL+ + F+PF + + +++G P S N WW L YQG+ PP+ RTE +FDPG+K+HI +PYIR+F+S +++FQF E+LC+ + PLH C +YQS G LL + MK G KPW E ++ I ++ + +LL++F PLT WLIK N +GW
Sbjct: 583 EQNTKNNEILGWPDFSWTPPIPDGYPGDIEKIANEKEADTFLSDYTKSAEVVWNDYTEASWAYNTNITEANKQLDKNLAMSGHTLQYGLQ--ARNYDYSDFQDPETQRILRKLSEIDKAALSEEEQKEYNQITSDMETIYSVAKVCKDGNTNCHPLDPDLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAY--WRSWYETPTLESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLV-------PYPNAAQVDATPAMIAKNWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKDREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWNLRLKYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQEGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNGETLGW 1190 HSP 2 Score: 342.043 bits (876), Expect = 1.223e-102 Identity = 178/520 (34.23%), Postives = 289/520 (55.58%), Query Frame = 2
Query: 404 WQQFHSKKMREMFEIITT-SVKSVDPEVFKRIIKIKNRIEHIYNKARPC----YKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W+ F ++++ I T +++ + I + ++ IY+ A+ C C S E I + T ++Y LL W W G+ +++ Y+ L +A + +G ++ ++ + F E L L+ + P+Y LHA+VR L E Y ++ N GPIPAH+ G++W+Q W NI+ ++ N V + + K + +F+ E + +G+ +M EFWE+S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P+ YR AN F E IGD ++LS+ T L+ IGLL + + +I+YL+ +ALE + F+PF + + ++++G P +R N WW L YQGI PPI R + FD G+KYHI PYIR+FVS +L+FQF ++LC K PLH C +Y+S+ G +L +++++G K W+E++K + +E + LL +F P+TQWLI+ N N +GW
Sbjct: 80 WENFTDPLLKKIISSIRTLGASNLNLTAREEYNTILSEMDSIYSTAKVCPPNATAKCWSL-EPEITEIMATSRSYKKLLYAWEGWHNSAGIPLKEKYLRFVQLSNEAYRMDGYKDTGAY-WRSWYASPTFEEDLDGLYQQLEPLYLNLHAFVRRKLYERYGAKYINLKGPIPAHLFGNMWSQQWNNIYDMMIPFPDKTN-IDVTNTMREK--GWNATHMFRVSEEFFTSLGLLEMPPEFWEKSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVEYYLQYKDQPVTYRRGANPGFHEAIGDVLSLSVSTPGHLKTIGLLDTVTNDKESDINYLLKMALEKIAFLPFGFLIDQWRWNVFSGRTPPTRYNYDWWNLRTKYQGICPPISRDDNQFDAGAKYHIPGNTPYIRYFVSFVLQFQFHKALCTAAKHTGPLHTCDIYRSQEAGKILGDVLRSGSSKSWQEVLKDMTGSEKMDVGPLLEYFTPVTQWLIEQNTKNNEILGW 594
BLAST of Angiotensin-converting enzyme vs. Ensembl Xenopus
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:100144634]) HSP 1 Score: 376.326 bits (965), Expect = 3.619e-115 Identity = 211/619 (34.09%), Postives = 337/619 (54.44%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLET-LMKLFDNVMPIYKQLHAYVRYCLAEYYPD-RFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ + N++ + F W P+ + YP + +E A+ +L + N + Y TNIT N L ++ + L A+ + + F + + + ++ K+ + E K +I + +E IY+ A+ C T + + + ++YD LL W WR +G QIR+ Y L +AA+ NG + ++ + + E LE+ + KL+D + P+Y LHAYVR L + Y D R N GPIPAH+LG++WAQ+W NI+ ++ P+ +V+ + ++ N ++F+ ++ + +G+ M EFW++S+ KP DR V CH+S+ DF N DFR+K C+ + +HHEMGH+QYF+ Y+ PIL+R AN F E IGD +ALS+ T L+ IGLL + + +I+YLM +AL+ + F+PF + + +++G P S N WW L YQG+ PP+ RTE +FDPG+K+HI +PYIR+F+S +++FQF E+LC+ + PLH C +YQS G LL + MK G KPW E ++ I ++ + +LL++F PLT WLIK N +GW
Sbjct: 608 EQNTKNNEILGWPDFSWTPPIPDGYPGDIEKIANEKEADTFLSDYTKSAEVVWNDYTEASWAYNTNITEANKQLDKNLAMSGHTLQYGLQ--ARNYDYSDFQDPETQRILRKLSEIDKAALSEEEQKEYNQITSDMETIYSVAKVCKDGNTNCHPLDPDLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAY--WRSWYETPTLESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLV-------PYPNAAQVDATPAMIAKNWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKDREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWNLRLKYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQEGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNGETLGW 1215 HSP 2 Score: 342.043 bits (876), Expect = 1.311e-102 Identity = 178/520 (34.23%), Postives = 289/520 (55.58%), Query Frame = 2
Query: 404 WQQFHSKKMREMFEIITT-SVKSVDPEVFKRIIKIKNRIEHIYNKARPC----YKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W+ F ++++ I T +++ + I + ++ IY+ A+ C C S E I + T ++Y LL W W G+ +++ Y+ L +A + +G ++ ++ + F E L L+ + P+Y LHA+VR L E Y ++ N GPIPAH+ G++W+Q W NI+ ++ N V + + K + +F+ E + +G+ +M EFWE+S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P+ YR AN F E IGD ++LS+ T L+ IGLL + + +I+YL+ +ALE + F+PF + + ++++G P +R N WW L YQGI PPI R + FD G+KYHI PYIR+FVS +L+FQF ++LC K PLH C +Y+S+ G +L +++++G K W+E++K + +E + LL +F P+TQWLI+ N N +GW
Sbjct: 105 WENFTDPLLKKIISSIRTLGASNLNLTAREEYNTILSEMDSIYSTAKVCPPNATAKCWSL-EPEITEIMATSRSYKKLLYAWEGWHNSAGIPLKEKYLRFVQLSNEAYRMDGYKDTGAY-WRSWYASPTFEEDLDGLYQQLEPLYLNLHAFVRRKLYERYGAKYINLKGPIPAHLFGNMWSQQWNNIYDMMIPFPDKTN-IDVTNTMREK--GWNATHMFRVSEEFFTSLGLLEMPPEFWEKSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVEYYLQYKDQPVTYRRGANPGFHEAIGDVLSLSVSTPGHLKTIGLLDTVTNDKESDINYLLKMALEKIAFLPFGFLIDQWRWNVFSGRTPPTRYNYDWWNLRTKYQGICPPISRDDNQFDAGAKYHIPGNTPYIRYFVSFVLQFQFHKALCTAAKHTGPLHTCDIYRSQEAGKILGDVLRSGSSKSWQEVLKDMTGSEKMDVGPLLEYFTPVTQWLIEQNTKNNEILGW 619
BLAST of Angiotensin-converting enzyme vs. Ensembl Xenopus
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:100144634]) HSP 1 Score: 375.941 bits (964), Expect = 4.823e-115 Identity = 211/619 (34.09%), Postives = 337/619 (54.44%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLET-LMKLFDNVMPIYKQLHAYVRYCLAEYYPD-RFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ + N++ + F W P+ + YP + +E A+ +L + N + Y TNIT N L ++ + L A+ + + F + + + ++ K+ + E K +I + +E IY+ A+ C T + + + ++YD LL W WR +G QIR+ Y L +AA+ NG + ++ + + E LE+ + KL+D + P+Y LHAYVR L + Y D R N GPIPAH+LG++WAQ+W NI+ ++ P+ +V+ + ++ N ++F+ ++ + +G+ M EFW++S+ KP DR V CH+S+ DF N DFR+K C+ + +HHEMGH+QYF+ Y+ PIL+R AN F E IGD +ALS+ T L+ IGLL + + +I+YLM +AL+ + F+PF + + +++G P S N WW L YQG+ PP+ RTE +FDPG+K+HI +PYIR+F+S +++FQF E+LC+ + PLH C +YQS G LL + MK G KPW E ++ I ++ + +LL++F PLT WLIK N +GW
Sbjct: 601 EQNTKNNEILGWPDFSWTPPIPDGYPGDIEKIANEKEADTFLSDYTKSAEVVWNDYTEASWAYNTNITEANKQLDKNLAMSGHTLQYGLQ--ARNYDYSDFQDPETQRILRKLSEIDKAALSEEEQKEYNQITSDMETIYSVAKVCKDGNTNCHPLDPDLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAY--WRSWYETPTLESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLV-------PYPNAAQVDATPAMIAKNWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKDREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWNLRLKYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQEGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNGETLGW 1208 HSP 2 Score: 342.043 bits (876), Expect = 1.642e-102 Identity = 178/520 (34.23%), Postives = 289/520 (55.58%), Query Frame = 2
Query: 404 WQQFHSKKMREMFEIITT-SVKSVDPEVFKRIIKIKNRIEHIYNKARPC----YKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W+ F ++++ I T +++ + I + ++ IY+ A+ C C S E I + T ++Y LL W W G+ +++ Y+ L +A + +G ++ ++ + F E L L+ + P+Y LHA+VR L E Y ++ N GPIPAH+ G++W+Q W NI+ ++ N V + + K + +F+ E + +G+ +M EFWE+S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P+ YR AN F E IGD ++LS+ T L+ IGLL + + +I+YL+ +ALE + F+PF + + ++++G P +R N WW L YQGI PPI R + FD G+KYHI PYIR+FVS +L+FQF ++LC K PLH C +Y+S+ G +L +++++G K W+E++K + +E + LL +F P+TQWLI+ N N +GW
Sbjct: 98 WENFTDPLLKKIISSIRTLGASNLNLTAREEYNTILSEMDSIYSTAKVCPPNATAKCWSL-EPEITEIMATSRSYKKLLYAWEGWHNSAGIPLKEKYLRFVQLSNEAYRMDGYKDTGAY-WRSWYASPTFEEDLDGLYQQLEPLYLNLHAFVRRKLYERYGAKYINLKGPIPAHLFGNMWSQQWNNIYDMMIPFPDKTN-IDVTNTMREK--GWNATHMFRVSEEFFTSLGLLEMPPEFWEKSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVEYYLQYKDQPVTYRRGANPGFHEAIGDVLSLSVSTPGHLKTIGLLDTVTNDKESDINYLLKMALEKIAFLPFGFLIDQWRWNVFSGRTPPTRYNYDWWNLRTKYQGICPPISRDDNQFDAGAKYHIPGNTPYIRYFVSFVLQFQFHKALCTAAKHTGPLHTCDIYRSQEAGKILGDVLRSGSSKSWQEVLKDMTGSEKMDVGPLLEYFTPVTQWLIEQNTKNNEILGW 612
BLAST of Angiotensin-converting enzyme vs. Ensembl Xenopus
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:100144634]) HSP 1 Score: 374.4 bits (960), Expect = 1.841e-114 Identity = 209/619 (33.76%), Postives = 336/619 (54.28%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLET-LMKLFDNVMPIYKQLHAYVRYCLAEYYPD-RFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ + N++ + F W P+ + YP + +E A+ +L + N + Y TNIT N ++ + + A+ + + F + + + ++ K+ + E K +I + +E IY+ A+ C T + + + ++YD LL W WR +G QIR+ Y L +AA+ NG + ++ + + E LE+ + KL+D + P+Y LHAYVR L + Y D R N GPIPAH+LG++WAQ+W NI+ ++ P+ +V+ + ++ N ++F+ ++ + +G+ M EFW++S+ KP DR V CH+S+ DF N DFR+K C+ + +HHEMGH+QYF+ Y+ PIL+R AN F E IGD +ALS+ T L+ IGLL + + +I+YLM +AL+ + F+PF + + +++G P S N WW L YQG+ PP+ RTE +FDPG+K+HI +PYIR+F+S +++FQF E+LC+ + PLH C +YQS G LL + MK G KPW E ++ I ++ + +LL++F PLT WLIK N +GW
Sbjct: 602 EQNTKNNEILGWPDFSWTPPIPDGYPGDIEKIANEKEADTFLSDYTKSAEVVWNDYTEASWAYNTNITEANKQVMLDKNLAMSGHTLQYGLQARNYDYSDFQDPETQRILRKLSEIDKAALSEEEQKEYNQITSDMETIYSVAKVCKDGNTNCHPLDPDLTEILAKSRDYDELLFAWKGWRDASGKQIREKYKRYVQLANKAAQLNGYNDNGAY--WRSWYETPTLESDVEKLYDELQPLYLNLHAYVRRALYKKYGDKRINLKGPIPAHLLGNMWAQSWSNIYELLV-------PYPNAAQVDATPAMIAKNWTPKRMFEESDNFFKSLGLLPMPQEFWDKSMIEKPKDREVVCHASAWDFYNRKDFRIKQCTVVNMDDLITVHHEMGHVQYFLQYKDQPILFREGANPGFHEAIGDVLALSVSTPKHLQSIGLLDKVEDNPESDINYLMSIALDKIAFLPFGFLMDQWRWKVFDGRTPDSEYNQQWWNLRLDYQGLVPPVLRTENDFDPGAKFHIPASVPYIRYFISFVIQFQFHEALCKAANQEGPLHKCDIYQSTQAGKLLGDAMKLGNSKPWPEAMQTITGQRNMSAHALLKYFQPLTDWLIKENTKNGETLGW 1211 HSP 2 Score: 338.961 bits (868), Expect = 2.188e-101 Identity = 179/522 (34.29%), Postives = 290/522 (55.56%), Query Frame = 2
Query: 404 WQQFHSKKMREMFEIITT-SVKSVDPEVFKRIIKIKNRIEHIYNKARPC----YKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIP--KTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W+ F ++++ I T +++ + I + ++ IY+ A+ C C S E I + T ++Y LL W W G+ +++ Y+ L +A + +G ++ ++ + F E L L+ + P+Y LHA+VR L E Y ++ N GPIPAH+ G++W+Q W NI+ ++ N V + + K + +F+ E + +G+ +M EFWE+S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P+ YR AN F E IGD ++LS+ T L+ IGLL + K + +I+YL+ +ALE + F+PF + + ++++G P +R N WW L YQGI PPI R + FD G+KYHI PYIR+FVS +L+FQF ++LC K PLH C +Y+S+ G +L +++++G K W+E++K + +E + LL +F P+TQWLI+ N N +GW
Sbjct: 97 WENFTDPLLKKIISSIRTLGASNLNLTAREEYNTILSEMDSIYSTAKVCPPNATAKCWSL-EPEITEIMATSRSYKKLLYAWEGWHNSAGIPLKEKYLRFVQLSNEAYRMDGYKDTGAY-WRSWYASPTFEEDLDGLYQQLEPLYLNLHAFVRRKLYERYGAKYINLKGPIPAHLFGNMWSQQWNNIYDMMIPFPDKTN-IDVTNTMREK--GWNATHMFRVSEEFFTSLGLLEMPPEFWEKSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHVEYYLQYKDQPVTYRRGANPGFHEAIGDVLSLSVSTPGHLKTIGLLDTVTNDKGKESDINYLLKMALEKIAFLPFGFLIDQWRWNVFSGRTPPTRYNYDWWNLRTKYQGICPPISRDDNQFDAGAKYHIPGNTPYIRYFVSFVLQFQFHKALCTAAKHTGPLHTCDIYRSQEAGKILGDVLRSGSSKSWQEVLKDMTGSEKMDVGPLLEYFTPVTQWLIEQNTKNNEILGW 613
BLAST of Angiotensin-converting enzyme vs. Ensembl Mouse
Match: Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874]) HSP 1 Score: 358.221 bits (918), Expect = 3.866e-113 Identity = 192/567 (33.86%), Postives = 307/567 (54.14%), Query Frame = 2
Query: 272 NRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIA-SFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM----SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
N A ++Y TNIT + +L + + + AK F F + ++ + + + ++V P+ + +I +E Y+ + CY TC+ E + N+ T + Y+ LL W WR + G I + + AK NG + S++ ++ +N + L KL+ + P+Y LHAYVR L +Y + N GPIPAH+LG++WAQ W NI+ ++ PF ++ + + + +IFK ++ + +G+ + EFW +S+ KP D R V CH S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ +R AN F E IGD MALS+ T L + LLS ++ +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ R++ +FDPGSK+H+ +PY+R+FVS +++FQF E+LC PLH C +YQSK G LL + MK G KPW E +K+I ++ + +++ +F PLT+WL+ N+ +GW
Sbjct: 90 NEYAEANWQYNTNITIEGSKILLEKSTEVSNHTLKYGTRAKTFDVSNFQNSSIKRIIKKLQNLDRAVLPPKELEEYNQILLDMETTYSLSNICYTNGTCMPL-EPDLTNMMATSRKYEELLWAWKSWRDKVGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSL--YESDNLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVA-------PFPSAPNIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWDFYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALSVSTPKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEALCRAAGHTGPLHKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGETLGW 646
BLAST of Angiotensin-converting enzyme vs. Ensembl Mouse
Match: Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874]) HSP 1 Score: 357.451 bits (916), Expect = 3.868e-110 Identity = 199/604 (32.95%), Postives = 321/604 (53.15%), Query Frame = 2
Query: 173 WLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIA-SFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM----SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W PL + YP+ E A+ ++ + + N A ++Y TNIT + +L + + + AK F F + ++ + + + ++V P+ + +I +E Y+ + CY TC+ E + N+ T + Y+ LL W WR + G I + + AK NG + S++ ++ +N + L KL+ + P+Y LHAYVR L +Y + N GPIPAH+LG++WAQ W NI+ ++ PF ++ + + + +IFK ++ + +G+ + EFW +S+ KP D R V CH S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ +R AN F E IGD MALS+ T L + LLS ++ +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ R++ +FDPGSK+H+ +PY+R+FVS +++FQF E+LC PLH C +YQSK G LL + MK G KPW E +K+I ++ + +++ +F PLT+WL+ N+ +GW
Sbjct: 400 WRPPLPDNYPEGIDLETDEAKADRFVEEYDRTAQVLLNEYAEANWQYNTNITIEGSKILLEKSTEVSNHTLKYGTRAKTFDVSNFQNSSIKRIIKKLQNLDRAVLPPKELEEYNQILLDMETTYSLSNICYTNGTCMPL-EPDLTNMMATSRKYEELLWAWKSWRDKVGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSL--YESDNLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVA-------PFPSAPNIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWDFYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALSVSTPKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEALCRAAGHTGPLHKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGETLGW 993 HSP 2 Score: 318.161 bits (814), Expect = 2.024e-95 Identity = 154/398 (38.69%), Postives = 241/398 (60.55%), Query Frame = 2
Query: 761 FQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
++ +F E+L ++ + P+Y LHAYVR L Y D++ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + +G+ M EFW S+ KP D R V CH+S+ DF N DFR+K C++ T+ + +HHEMGH+QY++ Y+ L + R AN F E IGD +ALS+ T + L KIGLL ++ + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+HI PYIR+FVS +L+FQF ++LC+ PLH C +YQS G+ L ++++ G +PW+E++K + ++ + + +LL +F P++QWL + N+ +GW
Sbjct: 3 YESPSFEESLEHIYHQLEPLYLNLHAYVRRALHRRYGDKYVNLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMVQKGWNATHMFRVSEEFFTSLGLSPMPPEFWAESMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTRVTMEQLATVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTNDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVARNETHFDAGAKFHIPNVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSAQAGAKLKQVLQAGCSRPWQEVLKDLVGSDALDAKALLEYFQPVSQWLEEQNQRNGEVLGW 395
BLAST of Angiotensin-converting enzyme vs. Ensembl Mouse
Match: Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874]) HSP 1 Score: 358.221 bits (918), Expect = 2.078e-108 Identity = 199/604 (32.95%), Postives = 321/604 (53.15%), Query Frame = 2
Query: 173 WLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIA-SFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM----SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W PL + YP+ E A+ ++ + + N A ++Y TNIT + +L + + + AK F F + ++ + + + ++V P+ + +I +E Y+ + CY TC+ E + N+ T + Y+ LL W WR + G I + + AK NG + S++ ++ +N + L KL+ + P+Y LHAYVR L +Y + N GPIPAH+LG++WAQ W NI+ ++ PF ++ + + + +IFK ++ + +G+ + EFW +S+ KP D R V CH S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ +R AN F E IGD MALS+ T L + LLS ++ +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ R++ +FDPGSK+H+ +PY+R+FVS +++FQF E+LC PLH C +YQSK G LL + MK G KPW E +K+I ++ + +++ +F PLT+WL+ N+ +GW
Sbjct: 633 WRPPLPDNYPEGIDLETDEAKADRFVEEYDRTAQVLLNEYAEANWQYNTNITIEGSKILLEKSTEVSNHTLKYGTRAKTFDVSNFQNSSIKRIIKKLQNLDRAVLPPKELEEYNQILLDMETTYSLSNICYTNGTCMPL-EPDLTNMMATSRKYEELLWAWKSWRDKVGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSL--YESDNLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVA-------PFPSAPNIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWDFYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALSVSTPKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEALCRAAGHTGPLHKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGETLGW 1226 HSP 2 Score: 352.443 bits (903), Expect = 2.716e-106 Identity = 195/605 (32.23%), Postives = 328/605 (54.21%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF---PWQQFHSKKMREMFEIITTSVKSVDPEVF-----KRIIKIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + PD ++ AE++ +M ++ +A+ + + TNIT +N + + ++ AK WQ F K+R I S++++ P ++ + + + IY+ + C+ TC S + + N+ + ++Y LL W W G+ ++ LY D + +A +++ + +F ++ +F E+L ++ + P+Y LHAYVR L Y D++ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + +G+ M EFW S+ KP D R V CH+S+ DF N DFR+K C++ T+ + +HHEMGH+QY++ Y+ L + R AN F E IGD +ALS+ T + L KIGLL ++ + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+HI PYIR+FVS +L+FQF ++LC+ PLH C +YQS G+ L ++++ G +PW+E++K + ++ + + +LL +F P++QWL + N+ +GW
Sbjct: 39 LQPGNFSPDEAGAQLFAESYNSSAEVVMF--QSTVAS--WAHDTNITEENARRQEEAALVSQEFAEVWGKKAKELYESIWQNFTDSKLRR----IIGSIRTLGPANLPLAQRQQYNSLLSNMSRIYSTGKVCFPNKTATCWSL-DPELTNILASSRSYAKLLFAWEGWHDAVGIPLKPLYQDFTAISNEAYRQDDFSDTGAF-WRSWYESPSFEESLEHIYHQLEPLYLNLHAYVRRALHRRYGDKYVNLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMVQKGWNATHMFRVSEEFFTSLGLSPMPPEFWAESMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTRVTMEQLATVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTNDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVARNETHFDAGAKFHIPNVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSAQAGAKLKQVLQAGCSRPWQEVLKDLVGSDALDAKALLEYFQPVSQWLEEQNQRNGEVLGW 628
BLAST of Angiotensin-converting enzyme vs. Ensembl Mouse
Match: Ace3 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 [Source:MGI Symbol;Acc:MGI:3644400]) HSP 1 Score: 336.265 bits (861), Expect = 1.027e-104 Identity = 182/564 (32.27%), Postives = 303/564 (53.72%), Query Frame = 2
Query: 272 NRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVN--FKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
N + Y TNIT N + Q + ++ + A+ F F ++ ++ M + KS P E ++ +E YN+A C CL+ E + + T ++ LL W WR G Q+R ++ D L +AA+ NG +++ + ++ + E L +L+ + P+Y LHAYVR L YY P+ + GPIPAH+LG++WAQ+W NI ++ P ++ K+ ++F+ + MGM FW +S+ KP D R V+CH+SS +F DFRVK C++ T+ ++ H+MGHIQYF+ YQ+L ++Y+ A+ AF+E +G +ALS+ + L GLLS + + E+++L+ +ALE + F+PF+ + F +++G++ N WW YQG+ PP+ R++++FDPG+K+HI +PYIR+F+ +L+FQ E+LCE + + PLH C Y SK G +L +++K G +PWRE+++ + +I + + L +F PL WL+ N +GW
Sbjct: 54 NEFMEATWNYVTNITKQNQKNMLQKEADRSQFMLYFSTRARMFRTDHFLNQDVKRMLRKLQNIDKSALPTEDLLEYNRLLTYMETAYNRAEVCLDEGPCLTL-EPDLQEIMATSRDQKELLWAWQGWRDAVGRQLRPVFEDYVRLSNKAAQYNGYKDMGAL-WRSKYESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRGPIPAHLLGNMWAQSWNNILDLVLP-----YPTKAPEDITAIMKIQHWRPEKMFEEANLFFTSMGMLPAPPAFWIKSMMEKPADGREVECHTSSWNFYKFNDFRVKKCTEVTLEDLLSVFHQMGHIQYFLQYQNLSVIYQEGASPAFEEAVGSVIALSVSSHKYLLARGLLSQPHQDSEEEVNFLLGIALEKIAFIPFSYLVDKFRWKIFDGTISKITYNQEWWNFRLKYQGLCPPVPRSDDDFDPGAKFHIPANVPYIRYFLGLILQFQLHEALCEASGHVGPLHQCDNYNSKVAGKILGDLLKLGSSRPWREVLQEVTGESNISTKAFLTYFKPLMDWLVTENVKQGDTLGW 610
BLAST of Angiotensin-converting enzyme vs. Ensembl Mouse
Match: Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [Source:MGI Symbol;Acc:MGI:1917258]) HSP 1 Score: 290.426 bits (742), Expect = 8.845e-87 Identity = 176/574 (30.66%), Postives = 290/574 (50.52%), Query Frame = 2
Query: 293 YRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFE---------DFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ------IFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLL-SNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIK--IINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
+ Y TNIT +N +++ + A+ F Q+ + ++ + + S S + + K++ I N + IY+ + C + CL E G+ + T +Y++ L W WR E G Q+R LY + L+ + A+ N + + + ++ +E + + F + P+Y+ LHAYVR L + YP + TG +PAH+LGD+W + W N++P+ PF + N ++ +NQ IF+ E +V +G+ MT FW S+ T+P D R V CH ++ D +G DFR+KMC+K T+ F HHEMGHIQY MAY P L R AN F E +G+ M+LS T L+ IGLL S+ + + EI++L+ AL V +PF + + ++ G +P + WW++ G+ P+ E DP S +H++ +IR++ ++ +FQF E+LC+ K LH C + S G L++++ G +PW + ++ + RN D++ LL +F PL WL + N+ N VGW
Sbjct: 48 WNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLL-EPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTV-------PFA--QKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHG-DFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKP--LLNYFQPLFDWLKEQNR--NSFVGW 606
BLAST of Angiotensin-converting enzyme vs. UniProt/SwissProt
Match: sp|Q50JE5|ACE_MESAU (Angiotensin-converting enzyme OS=Mesocricetus auratus OX=10036 GN=Ace PE=2 SV=1) HSP 1 Score: 367.851 bits (943), Expect = 4.502e-111 Identity = 207/621 (33.33%), Postives = 329/621 (52.98%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDR-FNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ------IFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ N + + + W PL + YP D ET AE ++ + + N A ++Y TNIT + +L Q + ++AK F F + ++ + + + ++V P+ + +I +E Y+ A CY TCL E + N+ T + Y+ LL W WR + G I L+ L + A NG + ++ ++ + L +L+ + P+Y LHAYVR L +Y + N GPIPAH+LG++WAQ W NI+ ++ PF N ++ + Q IFK + + +G+ ++ EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ +R AN F E IGD +ALS+ T L + LLS+ ++ +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ R++++FDPGSK+H+ +PYIR+FVS +++FQF E+LC PLH C +YQSK G LL + MK G KPW E +K+I ++ + +++ +F PLT+WL+ N+ +GW
Sbjct: 618 EQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLVTDETEAERFVEEYDRTARVLWNEYAEANWQYNTNITLEASKILLQKNKKVANHTLKYGTLAKKFDVSNFQNYTIKRIIKKVQNMDRAVLPPKELEEYNQILMDMETTYSIANVCYLNGTCLHL-EPDLTNVMATSRKYEELLWVWKSWRDKVGRAILPLFPKYVELSNKIAHLNGYADGGD-SWRSSYESKSLEQDLEQLYQELQPLYLNLHAYVRRSLHRHYGSQHINLDGPIPAHLLGNMWAQTWSNIYDLVA-------PFPS--APNLDATEAMIKQGWTPRRIFKEADDFFTSLGLLPVSEEFWNKSMLEKPGDGREVVCHASAWDFYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQDDFDPGSKFHVPANVPYIRYFVSFIIQFQFHEALCRAAGHTGPLHKCDIYQSKEAGKLLADTMKMGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGETLGW 1227 HSP 2 Score: 360.533 bits (924), Expect = 2.152e-108 Identity = 202/600 (33.67%), Postives = 324/600 (54.00%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF---PWQQFHSKKMREMFEIITTSVKSVDPEVFKRII-KIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSK-MSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + D + AE++ +++ ++ +A+ + Y TN+T +N L + + ++ AK Q F K+R + E I T + P ++ ++N + IY+ ++ C TC S E + N+ + ++Y LL W W G+ ++ LY D L +A K++G + ++ + +F ETL L+ + P+Y LHAYVR L Y D++ N GPIPAH+LGD+WAQ+W NI+ ++ N N + K +V +F+ E + MG+ M EFW S+ KP D R V CH+S+ DF N DFR+K C++ T+ S +HHEMGH+QY++ Y+ L + R AN F E IGD +ALS+ T + L KIGLL + + +I+YL+ +ALE + F+PF + + +++G P SR N WW YQGI PP+ R E +FD G+K+HI G PYIR+FVS +L+FQF ++LC+ PLH C +YQS G+ L +++ G +PW+E++K + ++ + + +LL +F P+ +WL + N+ +GW
Sbjct: 40 LQPGNFSADEIGAHLFAESYNSSAEQVIF--QSTVAS--WAYDTNMTEENARLQEEAELIWQEFAEVWGKKAKELFDAIRQNFTDSKLRRVIETIRTLGPANLPLARRQQYNSLQNNMNRIYSTSKVCLPNKTATCWSL-EPELTNILASSRSYAKLLFAWESWHDVVGIPLKPLYQDFTALSNEAYKQDGFSDTGAY-WRSAYDSPSFEETLEHLYHQLEPLYLNLHAYVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWDNIYDMVVPFPNKPN----LDVTNTMVQKGWNVTHMFRVAEEFFTSMGLSPMPPEFWAESMLEKPTDGREVVCHASAWDFFNRKDFRIKQCTRITMEQLSTVHHEMGHVQYYLQYKDLTVPLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDLESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGHTPPSRYNFDWWYFRTKYQGICPPVVRNETHFDAGAKFHIPSGTPYIRYFVSFILQFQFHQALCKEAGHQGPLHQCDIYQSTQAGAKLQRVLQAGYSRPWQEVLKEMVGSDTLDAQALLEYFQPVIRWLQEQNQRNGEVLGW 629
BLAST of Angiotensin-converting enzyme vs. UniProt/SwissProt
Match: sp|P47820|ACE_RAT (Angiotensin-converting enzyme OS=Rattus norvegicus OX=10116 GN=Ace PE=1 SV=1) HSP 1 Score: 358.992 bits (920), Expect = 7.242e-108 Identity = 197/605 (32.56%), Postives = 326/605 (53.88%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF---PWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIK-----NRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + D ++ A+++ +M ++ + + TNIT +N L + + ++ AK WQ F +K+R I SV+++ P +++ + + IY+ + C+ TC S + + N+ + +NY +L W W G+ +R LY D L +A +++G + ++ ++ +F E+L L+ V P+Y LHA+VR L Y D++ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + +G+ M EFW S+ KP D R V CH+S+ DF N DFR+K C++ T+ S +HHEMGH+QY++ Y+ L + R AN F E IGD +ALS+ T + L KIGLL + + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+HI PYIR+FVS +L+FQF ++LC+ PLH C +YQS G+ L ++++ G +PW+E++K + ++ + + +L+ +F P++QWL + N+ +GW
Sbjct: 40 LQPGNFSADEAGAQLFADSYNSSAEVVMFQS----TAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTDQKLRR----IIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSL-DPELTNILASSRNYAKVLFAWEGWHDAVGIPLRPLYQDFTALSNEAYRQDGFSDTGAY-WRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGW 629 HSP 2 Score: 358.992 bits (920), Expect = 7.390e-108 Identity = 203/624 (32.53%), Postives = 326/624 (52.24%), Query Frame = 2
Query: 110 SNKFAEKESINSDYEVFDSFYWLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM----SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
S E+ N + + + W PL + YP+ E A ++ + + N A + Y TNIT + +L Q + + AK F F + ++ + + + ++V P + +I +E Y+ A CY TCLS E + N+ T + Y+ LL W WR + G I + + + AK NG + A ++ ++ + L KL+ + P+Y LHAYVR L +Y + N GPIPAH+LG++WAQ W NI+ ++ PF ++ + + + +IFK ++ + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ +R AN F E IGD +ALS+ T L + LLS+ ++ +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ R++ +FDPGSK+H+ +PYIR+F+S +++FQF E+LC PL+ C +YQSK G LL + MK G K W E +KII ++ + +++ +F PLT+WL+ N+ +GW
Sbjct: 613 SQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSL-EPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSD-AGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVA-------PFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRHGETLGW 1227
BLAST of Angiotensin-converting enzyme vs. UniProt/SwissProt
Match: sp|Q9GLN7|ACE_PANTR (Angiotensin-converting enzyme OS=Pan troglodytes OX=9598 GN=ACE PE=3 SV=1) HSP 1 Score: 358.221 bits (918), Expect = 1.069e-107 Identity = 200/606 (33.00%), Postives = 326/606 (53.80%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF---PWQQFHSKKMREMFEIITTSVKSVDPEVFKRII--KIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ------IFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + D ++ A+++ +++ ++ + + TNIT++N + + ++ AK WQ F ++R + + T + S + + KR + + + IY+ A+ C TC S + + N+ + ++Y LL W W G+ ++ LY D L +A K++G + ++ + F + L L+ + P+Y LHA+VR L Y DR+ N GPIPAH+LGD+WAQ+W NI+ ++ PF + N ++ + Q +F+ E + + + M EFWE S+ KP D R V CH+S+ DF N DFR+K C++ T+ S +HHEMGHIQY++ Y+ LP+ R AN F E IGD +ALS+ T + L KIGLL N+ + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+H+ PYIR+FVS +L+FQF E+LC+ PLH C +YQS G+ L ++++ G +PW+E++K + + + + LL++F P+TQWL + N+ +GW
Sbjct: 32 LQPGNFSADEAGAQLFAQSYNSSAEQVLFQS----VAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPVWQNFTDPQLRRIIGAVRT-LGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSL-DPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAY-WRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVV-------PFP--DKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRGGANPGFHEAIGDVLALSVSTPAHLHKIGLLDNVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPNSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYQSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGW 621 HSP 2 Score: 350.903 bits (899), Expect = 5.828e-105 Identity = 205/617 (33.23%), Postives = 319/617 (51.70%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ N + + + W PL + YP D E A ++ + + N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR+FVS +++FQF E+LC+ PLH C +YQSK G L MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 610 EQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARRFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHTNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 1219
BLAST of Angiotensin-converting enzyme vs. UniProt/SwissProt
Match: sp|P09470|ACE_MOUSE (Angiotensin-converting enzyme OS=Mus musculus OX=10090 GN=Ace PE=1 SV=3) HSP 1 Score: 358.221 bits (918), Expect = 1.454e-107 Identity = 199/604 (32.95%), Postives = 321/604 (53.15%), Query Frame = 2
Query: 173 WLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIA-SFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM----SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
W PL + YP+ E A+ ++ + + N A ++Y TNIT + +L + + + AK F F + ++ + + + ++V P+ + +I +E Y+ + CY TC+ E + N+ T + Y+ LL W WR + G I + + AK NG + S++ ++ +N + L KL+ + P+Y LHAYVR L +Y + N GPIPAH+LG++WAQ W NI+ ++ PF ++ + + + +IFK ++ + +G+ + EFW +S+ KP D R V CH S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ +R AN F E IGD MALS+ T L + LLS ++ +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ R++ +FDPGSK+H+ +PY+R+FVS +++FQF E+LC PLH C +YQSK G LL + MK G KPW E +K+I ++ + +++ +F PLT+WL+ N+ +GW
Sbjct: 633 WRPPLPDNYPEGIDLETDEAKADRFVEEYDRTAQVLLNEYAEANWQYNTNITIEGSKILLEKSTEVSNHTLKYGTRAKTFDVSNFQNSSIKRIIKKLQNLDRAVLPPKELEEYNQILLDMETTYSLSNICYTNGTCMPL-EPDLTNMMATSRKYEELLWAWKSWRDKVGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSL--YESDNLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVA-------PFPSAPNIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWDFYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALSVSTPKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEALCRAAGHTGPLHKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGETLGW 1226 HSP 2 Score: 352.443 bits (903), Expect = 1.900e-105 Identity = 195/605 (32.23%), Postives = 328/605 (54.21%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF---PWQQFHSKKMREMFEIITTSVKSVDPEVF-----KRIIKIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + PD ++ AE++ +M ++ +A+ + + TNIT +N + + ++ AK WQ F K+R I S++++ P ++ + + + IY+ + C+ TC S + + N+ + ++Y LL W W G+ ++ LY D + +A +++ + +F ++ +F E+L ++ + P+Y LHAYVR L Y D++ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + +G+ M EFW S+ KP D R V CH+S+ DF N DFR+K C++ T+ + +HHEMGH+QY++ Y+ L + R AN F E IGD +ALS+ T + L KIGLL ++ + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+HI PYIR+FVS +L+FQF ++LC+ PLH C +YQS G+ L ++++ G +PW+E++K + ++ + + +LL +F P++QWL + N+ +GW
Sbjct: 39 LQPGNFSPDEAGAQLFAESYNSSAEVVMF--QSTVAS--WAHDTNITEENARRQEEAALVSQEFAEVWGKKAKELYESIWQNFTDSKLRR----IIGSIRTLGPANLPLAQRQQYNSLLSNMSRIYSTGKVCFPNKTATCWSL-DPELTNILASSRSYAKLLFAWEGWHDAVGIPLKPLYQDFTAISNEAYRQDDFSDTGAF-WRSWYESPSFEESLEHIYHQLEPLYLNLHAYVRRALHRRYGDKYVNLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMVQKGWNATHMFRVSEEFFTSLGLSPMPPEFWAESMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTRVTMEQLATVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTNDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVARNETHFDAGAKFHIPNVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSAQAGAKLKQVLQAGCSRPWQEVLKDLVGSDALDAKALLEYFQPVSQWLEEQNQRNGEVLGW 628
BLAST of Angiotensin-converting enzyme vs. UniProt/SwissProt
Match: sp|P12821|ACE_HUMAN (Angiotensin-converting enzyme OS=Homo sapiens OX=9606 GN=ACE PE=1 SV=1) HSP 1 Score: 352.829 bits (904), Expect = 1.337e-105 Identity = 198/602 (32.89%), Postives = 323/602 (53.65%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGF--P-WQQFHSKKMREMFEIITTSVKSVDPEVFKRII--KIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P + D ++ A+++ +++ ++ + + TNIT++N + + ++ AK P WQ F ++R + + T + S + + KR + + + IY+ A+ C TC S + + N+ + ++Y LL W W G+ ++ LY D L +A K++G + ++ + F + L L+ + P+Y LHA+VR L Y DR+ N GPIPAH+LGD+WAQ+W NI+ ++ N +V + + N +F+ E + + + M EFWE S+ KP D R V CH+S+ DF N DFR+K C++ T+ S +HHEMGHIQY++ Y+ LP+ R AN F E IGD +ALS+ T L KIGLL + + +I+YL+ +ALE + F+PF + + +++G P SR N WW L YQGI PP+ R E +FD G+K+H+ PYIR+FVS +L+FQF E+LC+ PLH C +Y+S G+ L ++++ G +PW+E++K + + + + LL++F P+TQWL + N+ +GW
Sbjct: 34 LQPGNFSADEAGAQLFAQSYNSSAEQVLFQS----VAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRT-LGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSL-DPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAY-WRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPN-----LDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGW 623 HSP 2 Score: 351.288 bits (900), Expect = 4.726e-105 Identity = 205/617 (33.23%), Postives = 319/617 (51.70%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDP-EVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASF--KMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ N + + + W PL + YP D E A ++ + + N A + Y TNIT++ +L Q + + + A+ F Q + ++ + + + ++ P + + KI +E Y+ A C+ +CL E + N+ T + Y+ LL W WR + G I Y L QAA+ NG + M+E E LE +LF + P+Y LHAYVR L +Y N GPIPAH+LG++WAQ W NI+ ++ + P E K + ++FK + + +G+ + EFW +S+ KP D R V CH+S+ DF NG DFR+K C+ + HHEMGHIQYFM Y+ LP+ R AN F E IGD +ALS+ T L + LLS+ + + +I++LM +AL+ + F+PF+ + + +++GS+ N WW L YQG+ PP+ RT+ +FDPG+K+HI +PYIR+FVS +++FQF E+LC+ PLH C +YQSK G L MK G +PW E +++I ++ + ++L +F PL WL N++ +GW
Sbjct: 612 EQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQL-EPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLE---RLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLV--VPFPSAPSMDTTEAMLK-QGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 1221
BLAST of Angiotensin-converting enzyme vs. TrEMBL
Match: I1ZIB1 (Angiotensin-converting enzyme (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 572.392 bits (1474), Expect = 0.000e+0 Identity = 274/590 (46.44%), Postives = 387/590 (65.59%), Query Frame = 2
Query: 185 LEYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLS-NIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
LE YP+ C E CA WL +VNEIMIRN NR+ANV ++YATNI +NL L + + + AK F + F S ++ E++ S + D R+I I+ +IE+IYN A PC+K C GE GI+ +FN K+YD L GYW+ WR TG +IR+L+I+R NLE Q A ++G + A FK+ DFQE NF + L FDN+ +YK+LH YVR+CL +YYP+RFNK+GPIPAHI+G W+++W N+F I+K+C +N + + + E++ + K++V+++FK ES Y +GM+ MT+EFW+RS+ K +I+DCH S+ F NG DFR+KMC+ K + ++I HEMGHIQYFMAY++L + +R SANS F E+ GD M L+ +T + L KIGLLS NI + EI+YL+ AL+N+ F+PFA+ +VNS+YNGSV + MN +W +V QGI PP+ERTE FD G+KYH+A G Y RH S L ++ FE++C ++ PLH C + SK VG+ +E+MK G + WR+ +KI+ + SDSLL F+ PL +WL K NK LN+ GW
Sbjct: 2 LEPYPNVCNGHSDENCARKWLQRVNEIMIRNNNRLANVNFKYATNINGNNLRELIKMKKKSAILSWKMHLKAKKFRLKFFKSPWVKRSLEMLKKSSRIFDSSTTLRLIDIRFQIENIYNTATPCFKGCQPPGEPGIIEIFNRVKDYDDLAGYWVAWRNATGSRIRNLFIERMNLENQKATDSGFHDSAEFKLATDFQETNFSQKLRNHFDNIFSLYKELHGYVRHCLHKYYPNRFNKSGPIPAHIVGSPWSESWHNVFSILKKCHKNIHEYDLRKEIDENIGKLTVHEMFKLSESFYSSLGMHNMTDEFWKRSITKKLKHKIMDCHPYSDSFENGVDFRIKMCTVKDLKDLTSIFHEMGHIQYFMAYRNLSVWFRESANSGFAELFGDVMGLAFRTPAYLRKIGLLSTNINNLRNSEINYLLTSALDNIVFIPFAISIEEYVNSVYNGSVGNNEMNKIYWDIVRKNQGIVPPVERTENYFDAGAKYHVAIGFAYTRHLFSYLFQYNIFEAMCNLSGYKGPLHQCHFFNSKEVGAKTLEMMKLGNTRNWRKTMKILTGTTSLNSDSLLTFYHPLYEWLKKKNKELNVKTGW 591
BLAST of Angiotensin-converting enzyme vs. TrEMBL
Match: A0A1S3GZX9 (Angiotensin-converting enzyme OS=Lingula unguis OX=7574 GN=LOC106150791 PE=3 SV=1) HSP 1 Score: 404.445 bits (1038), Expect = 1.987e-128 Identity = 220/620 (35.48%), Postives = 345/620 (55.65%), Query Frame = 2
Query: 215 ETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMRE----MFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCY----KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVN----FKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDL----EIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW*K-IINIKTSFLYCFLNEQKMVFEDL 2017
E AE WL N + N+ + Y TNI++ N + ++ + ++ A+ W + + K E F++IT D +R+ + +++E IY+K + C +CL E +VNL T ++YD LL W WR TG IRDLY + + +AAKENG ++ F +F+++N + + LFD V P+Y+QLHAYVR L Y +++ + TGPIPAH+LG++WAQ W I +++ P+ V+ K +V ++FKT E+ + +GM MT EFWE+S+ KP D R V CH+S+EDF N D+R+KMC++ IHHEMGH+QY+M Y H P +YR AN+ F E +GDT+ALS+ T L K+ LL +I +L ++++LM +AL+ + F+PF ++ + ++ G S N WW L YQGI PP+ R+E +FDPG+K+H+ +PYIR+FVS L++FQF +LC+ P+H C +YQS G L +++ G +PW + ++++ +I ++L +F PL +L+K NK N +GW + ++ L E K +FE+L
Sbjct: 49 EEKAEAWLKDYNTKLAVRSGIACNLNWNYETNISNANAKKIENNQVEQAEWNRKKAQEAR--EWLKKKTSKFSEDTLRQFKLITMDASLRDDADVRRMSYLLSQMESIYDKGKVCRPHSEASCLPL-EPDLVNLMMTSRDYDELLWAWKSWRDVTGPPIRDLYREFVVFQNKAAKENGFADMGEFWRISNFEDKNLDKIVDGLFDQVKPLYQQLHAYVRRKLINQYGEKYVSPTGPIPAHLLGNMWAQQWDLILDLLQ-------PYPNVPSVDVTSALKKQNYTVQKMFKTAEAFFCSLGMDNMTKEFWEKSMVVKPTDGREVQCHASAEDFHNASDYRIKMCTEIDYDNLYVIHHEMGHVQYYMQYSHQPDIYRNGANAGFHEAVGDTIALSVATPEHLHKLKLLDDIGDDKELREKQDLNFLMKMALQKLAFLPFGLLIDKWRWDVFRGHTNASNYNQKWWDLRLRYQGIAPPVPRSELDFDPGAKFHVPANVPYIRYFVSFLIQFQFQRALCDAAGHTGPIHHCDIYQSTAAGEKLKKMLSLGSSRPWPDAMEVLTGQREIDPSAILEYFKPLQDFLVKENK--NEIIGWEENSEDLMAGLQDDALEELKHLFEEL 656
BLAST of Angiotensin-converting enzyme vs. TrEMBL
Match: C3Z9J8 (Angiotensin-converting enzyme OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_287032 PE=3 SV=1) HSP 1 Score: 393.275 bits (1009), Expect = 4.674e-124 Identity = 219/609 (35.96%), Postives = 334/609 (54.84%), Query Frame = 2
Query: 152 EVFDSFYWLTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCY--KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIAS-FKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ------IFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIP--KTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ DS L L+ PD E A WL + NE + + + + A + +TNIT +N + + K+ + K F F S ++ F +IT S S D E +++ +I +E IY+ + C TCL + + + ++YD L W+ WR G ++D Y + L + A+ENG + ++ + + E + +++ V P+Y QLHAYVR L+E Y D+ TG IPAH+ G++WAQ W NI+ I+ PF + +S V Q +FKT E+ +V +G+ M FW++S+ +P DR V CH+S+EDF + D R+KMC+K IHHEMGHI+YF+ Y+ LYR AN F E +GDT+ALS+ T L+KIGLL NI + + +I+ L+ +AL V F+PF ++ + +++G + + N+ WW L YQGIKPP+ERT+E+FDPG+KYHI G PYIR+F S + +FQF ++LCE PLH C +YQSK G+ L ++ G+ KPW E +K I + + ++L++F PL +WL + NK N +GW
Sbjct: 78 ELIDS---LKELKSTPD----EEKAMKWLEEYNEELRQRQAKSAEANWAQSTNITDENAAKVVDVTMELTKWSLKKMEEGKKFDTSGF-SDDVKRQFGMITKSGSSSDEEKTRKVAEIGTELEKIYSTSTACLPSGTCLKL-DPDLEGILAKSRDYDRLTWAWLSWRDAVGPPMKDKYAEWVALMNEGAQENGYADKGVIWRGAYEMPNDTLEEMVDGVWEKVKPLYTQLHAYVRRKLSETYGEDKVLTTGHIPAHLFGNMWAQQWNNIYDIVV-------PFP--DQPAIDVSDTMVEQGYDPLRMFKTAEAFFVSIGLRPMPQVFWDKSMIVRPVDREVVCHASAEDFYHDSDVRIKMCTKVNQEDLQTIHHEMGHIEYFLTYEDQKTLYRGGANPGFHEAVGDTIALSVNTPGHLKKIGLLQNIEGNQGTEFQINELLKMALSKVAFLPFGLLIDKWRWRVFSGDITPDKFNTEWWNLRMKYQGIKPPVERTDEDFDPGAKYHIPSGTPYIRYFFSFVAQFQFQQALCEEAGHDGPLHTCDIYQSKKAGAKLKNMLSMGESKPWPEAMKAITGQDKLDPSAILKYFEPLEKWLREQNK--NEELGW 666
BLAST of Angiotensin-converting enzyme vs. TrEMBL
Match: A0A1S3I8D7 (Angiotensin-converting enzyme OS=Lingula unguis OX=7574 GN=LOC106161991 PE=3 SV=1) HSP 1 Score: 386.726 bits (992), Expect = 1.212e-121 Identity = 205/581 (35.28%), Postives = 319/581 (54.91%), Query Frame = 2
Query: 224 AENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMF----EIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNI 1930
A WL N+ R + + YATNIT N + I +++ A F W+ F +R F ++ + ++ D ++R+I + ++E Y++ + C K TCL E G+ L T +NY LL W WR TG +IRD Y + +L +AA ENG ++ + + +F + L +L++ + P+Y LHAYV+ L A+Y F +G IPAH+LG++WAQ+W NIF I++ PF V+ +N ++F + + +G+ M EFW+ S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P++YR AN F E +GD +ALS+ T + L++IGLL N+ + I+YLM +AL+ + F+PF + + ++NGS+ N WWKL YQG+ PPI R E +FDPG+KYHI PYIR+FVS +L+FQF E+LC + PLH C +Y+S G+ L ++K G KPW E ++ + ++ ++++L +F PL WL N+ I
Sbjct: 31 AAQWLRDANDRAGRVYYNLQVARWVYATNITKFNGERQHNASIMSAEFDREAAENATSFAWENFTDSDLRRQFRKISDVGSAALLRKDKAKYERLISLVTKMETTYSEGQVCDKKGTCLDL-EPGLTRLMATSRNYSELLDAWKGWRDATGRKIRDDYKEFVSLSNEAAVENGYRDTGDY-WRSWYDTADFRDQLEQLYEEMKPLYLNLHAYVKNKLKAKYGESLFPPSGHIPAHLLGNMWAQSWNNIFDIVE-------PFAGKPSVDVTPKMKELNYTPRRMFNISDEFFTSLGLEAMPQEFWDHSMLEKPTDGRKVVCHASAWDFYNKKDFRIKQCTDITMDDLITVHHEMGHVEYYLQYKEQPVVYRRGANPGFHEAVGDVLALSVSTPTHLKEIGLLDNVTNDNESVINYLMSIALDKIAFIPFGYLMDQWRWGVFNGSIKFEEYNKEWWKLRCKYQGVSPPIHRNESDFDPGAKYHIPANTPYIRYFVSYVLQFQFHEALCNTANQTGPLHMCDIYRSTEAGAKLGNMLKLGSSKPWPEALEKVTGTRNMSANAILLYFKPLIDWLKVQNQGQTI 602
BLAST of Angiotensin-converting enzyme vs. TrEMBL
Match: R7T3G6 (Angiotensin-converting enzyme OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_171751 PE=3 SV=1) HSP 1 Score: 377.867 bits (969), Expect = 1.047e-120 Identity = 181/468 (38.68%), Postives = 285/468 (60.90%), Query Frame = 2
Query: 572 ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQ-EENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDR-FNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKM--SVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNG--FDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLE-----IDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E + T +++D LL W+ WR TG ++D Y + +L QAA +N N+ S + +++ +++ ++ + L+D+V P+Y+Q+HAYVR L E YPD + GPIPAHILG++WAQ W NI I+ P ++V + +V ++F+ ES + +GM MT+ FWE+S+ TKP+ R V+CH S+ D ++ DFR+KMC++ T Y +HHEMGHIQYFM Y H P ++++ AN+AF E IGDT+ALS+ + L+ IGL+ D E +++LM ALE V F+PF + + +++G + N+ WW+ YQG+ PP+ R++++FDPGSKYH+ +PYIR+F+S + +FQF ESLC PLH C +Y+SK+ G LL+ ++ G +PW+E ++++ + +D++ +FAPLT+W+ K NK I GW
Sbjct: 2 EPEFTEIMATSRDWDELLWAWVAWRNATGPFMKDKYTEATSLMNQAALDNNYDNLGSAWRYANYEMDQDLIDMVDDLYDDVKPLYEQIHAYVRGKLIEAYPDHDIDPEGPIPAHILGNMWAQEWNNILDIVLPY-----PDSASYDVTEAMQNQGYTVEKLFRLSESFFASLGMDNMTDTFWEKSMMTKPDGRNVECHGSASDMASADCSDFRIKMCTQITQDYLQTVHHEMGHIQYFMQYCHQPFVFQSGANAAFHEAIGDTIALSVMSPEHLKTIGLIEEQGAGSDDEQQKKTLNFLMKAALEKVAFLPFGYLIDKWRWDVFSGEITPEEYNTKWWQYRIKYQGVAPPVRRSDDDFDPGSKYHVPANVPYIRYFLSFIGQFQFHESLCSAAGHKGPLHACDIYRSKDAGRLLMSVLSRGSSRPWKETMQVMTGGKQFSADAIKEYFAPLTKWIQKQNKHSKI--GW 462
BLAST of Angiotensin-converting enzyme vs. Ensembl Cavefish
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:103040258]) HSP 1 Score: 351.288 bits (900), Expect = 4.532e-106 Identity = 197/620 (31.77%), Postives = 321/620 (51.77%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP----DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSV-DPEVFKRIIKIKNRIEHIYNKARPCYK--TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMS----VNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E+ + + + F W+ P+ E YP D E A+ +L + N N + Y TNI N + + + + A+ + F ++ + + ++ ++V + K + +E Y+ A+ C TCL + + + ++YD LL W WR +G ++R Y+ L AA+ NG + +F ++ F E L L+ ++ P+Y LH+YVR L +Y R N GPIPAH+LG++WAQ W I +++ P+ +V+ + ++ N++F+ E+ + +G+ M +EFW++S+ KP D R V CH+S+ DF N DFR+K C+ + +HHEMGH+QYF+ Y+ PI +R AN F E IGD +ALS+ T L IGLL + + + I++LM +AL+ + F+PF + + +++G + +S N WW L YQG+ PP+ RTE +FDPG+K+HI +PY+R+FVS +++FQF ++LC+ PLH C +YQSK G LL ++MK G KPW E + +I + L+ +F PL WL + N +GW
Sbjct: 599 EQNRLTGETLGWPDFDWMPPVPEGYPEDVADKITDEAQAKQFLAEYNSTAETVWNAYTEASWSYNTNINEANKQNMLEKNLEMANHTKTYGLEARKYDTSDFQDSSVKRILKKLSDLERAVLSDDDLKEYNNLLASMETTYSVAKVCKDDGTCLPL-DPDLNKIMAESRDYDELLFAWQGWRNASGRELRQSYVRYVELANLAARSNGHADNGAF-WRSLYETPTFEEDLEALWKDLQPLYLNLHSYVRRALFKKYGAKRINLKGPIPAHLLGNMWAQTWSGIMDLVR-------PYPNAAQVDVTQAMIAKGWDANRMFRESENFFTSVGLLPMPDEFWQKSMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTVINMDDLITVHHEMGHVQYFLQYKDQPISFRDGANPGFHEAIGDVLALSVSTPKHLHTIGLLDKLEENAESTINFLMSIALDKIAFLPFGYLMDQWRWKVFDGRISSSEYNKEWWNLRLKYQGLCPPVTRTEVDFDPGAKFHIPANVPYVRYFVSFVVQFQFHKALCDTAGHTGPLHNCDIYQSKEAGKLLGDVMKLGFSKPWPEAMAMITGQPQMSVQPLMEYFQPLITWLEQENAKNGDVLGW 1209 HSP 2 Score: 346.665 bits (888), Expect = 1.983e-104 Identity = 184/564 (32.62%), Postives = 314/564 (55.67%), Query Frame = 2
Query: 293 YRYATNITSDNLMLLNQFRITKVKYENNLISIAKG-FPWQQFHSKKMREMFEII-------TTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKT--CLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYY-PDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSR--NNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
+ Y TN+T++N + Q + + ++ AK FP + ++ +II ++ + + E + I+ +++++IY+ A+ C K C A E + + ++Y LL W W +G+ ++DLY + L A+ +G + ++ ++ F + L LF + P+Y+ LHA+VR L ++Y P N GPIPAH+LG++W+Q W NI+ ++ N + + E N+ + M F+ E + +G+ +M +FW++S+ KP+D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH++Y++ Y+ P+ +R AN F E +GD ++LS+ T L IGLL +P + +I+YL+ +ALE + F+PF + + +++G P R N+ WW L YQGI PP+ RTEE+FDPG+KYHI PYIR+FVS +L+FQF + LC+ PLH C +Y+S G++L ++++ G KPW E+++ + + +L+ +F P+T WL + N++ +GW
Sbjct: 57 WEYNTNLTNENSLQQIQASMIEQEFTEAWGMKAKATFPDALMETFTNPDLIKIIKKINVLGAANLPTAERERYNTIL---SQMDNIYSTAKVCPKPEECW-ALEPELKEILANSQSYKKLLYAWEGWHNVSGIPLKDLYPEFVQLSNNASVMDGFDDTGAY-WRSWYESPTFEQDLENLFKQLQPLYQNLHAFVRRKLYDFYGPKYINLKGPIPAHLLGNMWSQTWNNIYNMMIPFPDKPNVDVTNAMVEKNYNATHM-----FRVAEEFFTSLGLKEMPQKFWDKSMLEKPDDGREVVCHASAWDFYNREDFRIKQCTIVTMEQLFTVHHEMGHVEYYLQYKDQPVSFRRGANPGFHEAVGDVLSLSVSTPKHLHTIGLLDTLPNDNETDINYLLKMALEKIAFLPFGYLIDQWRWGVFSGRTPPERYNAEWWYLRTKYQGICPPVRRTEEHFDPGAKYHIPGNTPYIRYFVSFILQFQFHQKLCQEAGHTGPLHTCDIYRSTQAGAVLEKVLQAGSSKPWTEVLQEALGTNKMDAAALMEYFLPVTTWLEEQNRLTGETLGW 610
BLAST of Angiotensin-converting enzyme vs. Ensembl Cavefish
Match: ace2 (angiotensin I converting enzyme 2 [Source:NCBI gene;Acc:103030208]) HSP 1 Score: 284.263 bits (726), Expect = 1.177e-84 Identity = 168/596 (28.19%), Postives = 301/596 (50.50%), Query Frame = 2
Query: 215 ETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSK-KMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKT----CLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMF----ED-----FQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN----QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRI-VDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLL-SNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
E A+++L+K +E R + + + Y TNIT++N L + +Y + + + FP Q + + ++ + ++ P+ R+ K+ N + IY+ C C + E G+ + ++Y L W WR + G ++R LY + +L+ +AAK N ++ + ED + + + + ++ +MP+YK+LHAYVR L YP G +PAH+LGD+W + W N++P+ P+ +++ + ++ ++FK E +V + M M FW S+ TKP D V CH ++ D N DFR+KMC+K + F HHEMGH QY MAY+HLP L R AN F E +G+ M+LS T S L+ +GLL ++ + + +I++L+ AL V +PF + + ++ G++P + WW++ G+ P+ R E DP + +H++ +IR+F ++ +FQ ++LC+ PL+ C + S + G+ L ++++ G+ K W ++ + + + + LL +F+ L +WL + N+ N GW
Sbjct: 21 EDRAKDFLLKFDEDASRLMYQYSLASWAYNTNITTENSNKLAEQGAIWSEYYSRVSEESNEFPIDQMSDELVILQLKSLQDKGSGALSPDKASRLSKVLNEMSTIYSTGTVCKIDNPFDCQTL-EPGLEEIMANSRDYYERLHVWEGWRVQVGKKMRKLYEEYADLKNEAAKLNNYKDYGDYWRANYETEDEPKYSYSRDELMRDVRSIYSEIMPLYKELHAYVRAKLQNTYPGHIASNGGLPAHLLGDMWGRFWTNLYPLAV-------PYPDKPDIDVSPAMVAQGWDEERLFKEAEKFFVSVNMSAMFPNFWTNSMLTKPTDGTKVVCHPTAWDMGNREDFRIKMCTKVNMDDFLTAHHEMGHNQYQMAYRHLPYLLRDGANEGFHEAVGEIMSLSAATPSHLQSLGLLPADFTEDMETDINFLLKQALTIVATLPFTYMLEEWRWQVFQGTIPKDQWMLRWWEMKRELVGVTEPLPRDESYCDPPALFHVSGDYSFIRYFTRTVYQFQLQDALCKEAGHTGPLYKCDITNSTDAGNKLRDMLELGRSKSWTRALEQVCGDTRMDARPLLSYFSTLYEWLKEENQKNNRASGW 608
BLAST of Angiotensin-converting enzyme vs. Ensembl Sea Lamprey
Match: ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1826]) HSP 1 Score: 376.711 bits (966), Expect = 4.998e-116 Identity = 208/615 (33.82%), Postives = 337/615 (54.80%), Query Frame = 2
Query: 125 EKESINSDYEVFDSFYWLTPL-EYYP---DSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEV-FKRIIKIKNRIEHIYNKARPCY-KTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGI-QNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDR-FNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
EKE++N + F W+ P+ + YP D ET A L + N + + + Y T+IT ++ L+ + + + A + W F + +R + I+ + PE K +I +R+E Y+ A+ C +TC+ + I + +NYD LL YW WR +G ++R+ Y+ L +AA NG N A ++ + E F L ++++ + P+Y LHAYVR L ++Y D N GPIPAH+LG++WAQ+W N+ ++ N V + K + +F + + +GM M EFW++S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH+QYF+ Y+ P+ +R AN F E IGD MALS+ T L++IGLL + + +I++L+ +AL+ + F+PF + + +++G +PT N WW L YQG+ PP+ RTE++FDPGSK+HI +PY R+FVS +++FQF E+LC + LH C +Y+SK+ G L ++M+ G + W+E +++I +++ + +LL++F PLT WL+K N+ +GW
Sbjct: 618 EKENVNETLG-WPEFAWVPPVPDDYPGNLDKITDETQAIALLEEYNTTAEKYWSEYNEASWTYNTDITEEHDKLVQEANLRMANHSLYFGRDALLYDWSNFQDEGVRRQLKKISQIGTAALPETELKEYNEIVSRMETAYSVAKVCRGETCIPL-DPDITAIMAESRNYDELLYYWQGWRDASGRKMREDYVRYVELSNKAAIANGFPDNGAQWR--SAYDTETFEADLERIYEELKPLYLNLHAYVRRKLHQHYGDEHVNLKGPIPAHLLGNMWAQSWNNLNSLVAPFP---NAPSVDATPAMQAQKWTPKMMFNVSDVFFTSLGMIPMPREFWDKSMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTVVTMDDLVTVHHEMGHVQYFLQYKEQPVPFRDGANPGFHEAIGDVMALSVATPKHLKEIGLLETVEDNSESDINFLLSMALDKIAFLPFGFLMDQWRWKVFDGRIPTEDYNKEWWNLRMKYQGLCPPVARTEDDFDPGSKFHIPASVPYDRYFVSFVIQFQFQEALCAAAGQKGDLHKCDIYKSKDAGDKLAKVMQLGSSRRWQEAMEMITGQQNMSAAALLKYFKPLTDWLVKENQKNGEVLGW 1225 HSP 2 Score: 310.071 bits (793), Expect = 7.607e-92 Identity = 191/610 (31.31%), Postives = 323/610 (52.95%), Query Frame = 2
Query: 176 LTPLEYYPDSCLSETCAENWLVKVNEIM--IRNENRIANVYYRYATNITSDNLML-----LNQFRITKV---KYENNLISIAKGFPWQQFHSKKMREMFEIITTS-VKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESG-----IVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLS-NIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L P +Y D ET AE +L N+ + E+ +A+ + Y TNIT +N L L + T+ K ++ +I+ GF +K++ E I+ ++ + + E + R++ + ++ IY+ + C S + I ++ T ++Y LL YW W G + Y L A++ + + + ++ F + L ++++ + P+Y LHAYVR L ++Y ++F N GPIPAH+LG++W+Q W NIF ++ P +V + + N +F+T E + +G+ +M EFW S+ KP D R V CH+S+ DF N DFR+K C+ T+ +HHEMGHI+Y++ Y+ + +R AN F E IGD ++LS+ T + L+ IGLL + + +I+YLM +ALE + F+PF + ++ +++G P R N WW L YQGI P + R +FD G+K+HI PYIR+FVS +++FQF ++LC + PL+ C + +++ G+LL + M+ G +PW E++K + + + + L+ +F P+ WL K N +N +GW
Sbjct: 39 LLPGDYSRD----ETGAEQFLADYNDTAEGVLYESVLAS--WNYNTNITEENQNLQVAASLKEQEFTEAWGQKAKDLFGNISHGF---NETNKRLLEQISILGSANLDITEREEYNRLL---SDMDAIYSTGKVCKPGQTSGTDCAPLDPTITDILATSRSYKKLLYYWEGWHNVVGRPLHSKYARFVELSNAASQLDDFADTGEY-WRSWYESATFRDDLERIYEELKPLYLNLHAYVRRKLHQHYGEKFVNLKGPIPAHLLGNMWSQQWNNIFDMVVPY-----PGKTSVDVTDTMVEQGWNATHMFRTSEDFFKDLGLLEMPPEFWSGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTIPTMEQLFTVHHEMGHIEYYLQYKDQHVSFRGGANPGFHEAIGDVLSLSVSTPTHLKTIGLLGPDYVGDKESDINYLMKMALEKIAFLPFGYLIDLWRWDVFSGKTPPERYNQDWWYLRTKYQGICPGVPRKSTDFDAGAKFHIPGNTPYIRYFVSFIIQFQFQKALCTAAQDKGPLYKCDIDKNQAAGNLLRKAMQMGSSRPWTEVMKEMTGTDKMSALPLIEYFKPVIDWLEKEN--VNETLGW 628
BLAST of Angiotensin-converting enzyme vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004373.1 (pep scaffold:Pmarinus_7.0:GL477858:25443:42821:1 gene:ENSPMAG00000003990.1 transcript:ENSPMAT00000004373.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 226.483 bits (576), Expect = 1.345e-67 Identity = 137/414 (33.09%), Postives = 213/414 (51.45%), Query Frame = 2
Query: 353 TKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAG------ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLL--SNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKL 1558
TK Y++ I GFP + +REM + + ++ E R+I +++ Y+ C K S+G E + ++ T ++Y LL YW WR + G +R Y L +A++ +G + F ++ E F L +L+D + P+Y +HAYVR L Y +R N GPIPAH+LGD+WAQ W I+ ++ P +V + + N +F+ E + +G+ +M EFW S+ KP D R V CH+S+ DF N DFR+K C+ T++ HHEMGH+QYF+ Y+ P+ +R AN F E IGD MALS+ T L+KIGLL S + + +I++L+ +AL + F+PF + + +++G P R N WW L
Sbjct: 7 TKYLYDD----IRDGFP--DDLRRLLREMRIMGSANLHPAAREELNRVIL---QMQTTYSTGAVC-KPGHSSGPDCFPLEPELDHIMATSRSYTQLLYYWEGWRTDVGRPLRAPYAHFVQLSNEASRADGFADTGEF-WRSVYETETFRADLERLYDELRPLYLHMHAYVRRRLHRRYGERLVNLRGPIPAHLLGDMWAQQWQGIYDLVVPY-----PGKTRVDVTSAMVEQGWNTTHMFRVSEEFFTSLGLMEMPPEFWNGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTSVTMTDLVRAHHEMGHVQYFLQYKEQPVPFRRGANPGFHEAIGDVMALSVATPRHLKKIGLLEPSYVEDPAESDINFLLWMALGKIAFLPFGFLVDQWRWDVFSGHTPPGRYNHDWWHL 404
BLAST of Angiotensin-converting enzyme vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004370.1 (pep scaffold:Pmarinus_7.0:GL477858:22090:39821:1 gene:ENSPMAG00000003990.1 transcript:ENSPMAT00000004370.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 202.601 bits (514), Expect = 9.607e-59 Identity = 129/387 (33.33%), Postives = 197/387 (50.90%), Query Frame = 2
Query: 293 YRYATNITSDNLMLLNQFRIT----------KVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAG------ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLL 1393
+ ++TN+T+ NL L + R+ K KY + I GFP + +REM + + ++ E R+I +++ Y+ C K S+G E + ++ T ++Y LL YW WR + G +R Y L +A++ +G + F ++ E F L +L+D + P+Y +HAYVR L Y +R N GPIPAH+LGD+WAQ W I+ ++ P +V + + N +F+ E + +G+ +M EFW S+ KP D R V CH+S+ DF N DFR+K C+ T++ HHEMGH+QYF+ Y+ P+ +R AN F E IGD MALS+ T L+KIGLL
Sbjct: 31 WGHSTNMTAVNLERLVEARLKMQEFTEAWGEKTKYLYD--DIRDGFP--DDLRRLLREMRIMGSANLHPAAREELNRVIL---QMQTTYSTGAVC-KPGHSSGPDCFPLEPELDHIMATSRSYTQLLYYWEGWRTDVGRPLRAPYAHFVQLSNEASRADGFADTGEF-WRSVYETETFRADLERLYDELRPLYLHMHAYVRRRLHRRYGERLVNLRGPIPAHLLGDMWAQQWQGIYDLVVPY-----PGKTRVDVTSAMVEQGWNTTHMFRVSEEFFTSLGLMEMPPEFWNGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTSVTMTDLVRAHHEMGHVQYFLQYKEQPVPFRRGANPGFHEAIGDVMALSVATPRHLKKIGLL 403
BLAST of Angiotensin-converting enzyme vs. Ensembl Nematostella
Match: EDO34063 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQE7]) HSP 1 Score: 339.347 bits (869), Expect = 1.936e-109 Identity = 176/485 (36.29%), Postives = 272/485 (56.08%), Query Frame = 2
Query: 503 IKNRIEHIYNKARPCYK-----TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
I N E IY+ + C TC+S + + NL + +N D L+ W WR +R ++ +L + A+++G+ + F+ E +F + KL+ +V P+YK+LHAYVR+ L + Y + +GPIPAH+LG++WAQNW I+ ++ Q + P V + + ++FK +S +V +G+ M FW +S+ KP ++ V CH+S+ DF D R+KMC++ IHHEMGH +YF+AY+ P YR AN F E IGDT+ALS+ T L +GLL +PK + I++LM AL +V +PF + + + G + S NS WW++ YQG+KPP+ R E +FDPG+K+HI PYI +FVS +L+FQF +LC + K PLH C++YQSK G E++ G+ +PW + + + ++ +D LL +FAPL +WL N +GW
Sbjct: 2 ITNMTE-IYSTGKVCLNITRNNTCMSL-DPDLGNLMSRSRNQDELVWAWRGWRDAVAPPVRGMFQQMVDLLNKGARQHGLGDYGHFERGEYEMGNDFTAVIKKLWTDVKPLYKELHAYVRFQLKKKYAG-MSGSGPIPAHLLGNMWAQNWDGIYDMV-QPYPDATPLDV--TPSLIKQHYTPEKMFKLAQSFFVSIGLDPMPKSFWNKSMLRKPGNKSVVCHASAFDFLKD-DVRIKMCTRLKQEDLITIHHEMGHCEYFLAYKDQPYAYRNGANPGFHEAIGDTIALSVVTPKHLNSVGLLYTLPKGDEASINFLMTQALSHVAPLPFTYLVDQWRWKVLAGEISPSNYNSAWWRMRTLYQGVKPPVARNESDFDPGAKFHIVSNSPYIGYFVSLILQFQFHRALCNLVKHTGPLHECSIYQSKEAGKKFKEMLAAGRSRPWPQTLFKLTGEREMSADPLLEYFAPLRKWLFNYRIKNNYTLGW 479
BLAST of Angiotensin-converting enzyme vs. Ensembl Nematostella
Match: EDO29688 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2Y1]) HSP 1 Score: 334.724 bits (857), Expect = 1.372e-107 Identity = 173/485 (35.67%), Postives = 269/485 (55.46%), Query Frame = 2
Query: 503 IKNRIEHIYNKARPCYK-----TCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
I N E IY+ + C TC+S + + NL + +N D L+ W WR +R ++ +L + A+++G+ + F+ E +F + KL+ +V P+YK+LHAYVR+ L + Y + +GPIPAH+LG++WAQNW I+ ++ Q + P V + + ++FK +S +V +G+ M FW +S+ KP ++ V CH+S+ DFS +KMC++ IHHEMGH +YF+AY+ P YR AN F E IGDT+ALS+ T L +GLL +PK + I++LM AL +V +PF + + + G + S NS WW++ YQG+KPP+ R E +FDPG+K+HI PYI +FVS +L+FQF +LC + K PLH C++YQSK G E++ G+ + W + + + ++ +D LL +FAPL +WL +GW
Sbjct: 2 ITNMTE-IYSTGKVCLNITRNNTCMSL-DPDLGNLMSRSRNQDELVWAWRGWRDAVAPPVRGMFQQMVDLLNKGARQHGLGDYGHFERGEYEMGNDFTAVIKKLWTDVKPLYKELHAYVRFQLKKKYAG-MSGSGPIPAHLLGNMWAQNWDGIYDMV-QPYPDATPLDV--TPSLIKQHYTPEKMFKLAQSFFVSIGLDPMPKSFWNKSMLRKPGNKSVVCHASAFDFSKMTSGAIKMCTRLKQEDLITIHHEMGHCEYFLAYKDQPYAYRNGANPGFHEAIGDTIALSVVTPKHLNSVGLLYTLPKGDEASINFLMTQALSHVAPLPFTYLVDQWRWKVLAGEISPSNYNSAWWRMRTLYQGVKPPVARNESDFDPGAKFHIVSNSPYIGYFVSLILQFQFHRALCNLAKHTGPLHECSIYQSKEAGKKFKEMLAAGRSRVWPQTLFKLTGEREMSADPLLEYFAPLRKWLFNYRIKNKYTLGW 480
BLAST of Angiotensin-converting enzyme vs. Ensembl Nematostella
Match: EDO37947 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEG1]) HSP 1 Score: 335.88 bits (860), Expect = 3.134e-106 Identity = 184/567 (32.45%), Postives = 293/567 (51.68%), Query Frame = 2
Query: 272 NRIANVYYR--------YATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYN--KARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
NR A YR Y TN+T N L Q + + + + A F + S+ + ++I S +P KR ++ ++++ IY+ K + LS + + ++Y+ LL W WR G IR LY ++ + AKENG ++ + ++ EN L+ ++ P+Y++LHAYVRY L++ Y + IPAH+ G++WAQ+W NI+ +++ ++ + V +++ + Q+ ES + +G+ + F+ RS+ KP DR V CH+S+ DF D R+K C+ T HHE+GHIQYF+ Y H P YR AN F E +GDT++LS+ T + L +IGLL + + +I+ LM +AL V F+PF + + ++ G + N WW+L YQGIKPP+ RTE +FDPG+KYHI PYIR+FVS +++FQF ++ CE PLH C++Y S G L ++K G+ KPW + +K + E++ L +F PL W+ +GW
Sbjct: 37 NRRAPFEYRNSELALWNYETNLTDFNQALKTQASLAFSMFTQSALVNASKFDANKL-SEDTKRQIKLIAASASPKNPADIKRKSELNSQMDKIYSSGKVKDANGEMLSLNPD-LYKILAESRDYERLLFVWKGWRDAVGPAIRPLYQQFVDISNKGAKENGWKDNGEY-WRSSYEVENLERIAEGLYSDLKPLYQELHAYVRYKLSQQY-SQVKSGDAIPAHLFGNMWAQSWANIYDLVEPYGNQSSLDVTRNMVKQGYTELRMVQL---AESFFTSIGLDPLPQSFYNRSMIVKPKDRGVVCHASAWDFLISRDVRIKQCTTITHDSLVTTHHELGHIQYFLQYAHQPYEYRTGANPGFHEAVGDTLSLSVDTPAHLHRIGLLDAVSNNTESDINALMKMALSKVAFLPFGFLIDQWRWRVFRGEITPQNYNRKWWELRTKYQGIKPPVCRTENDFDPGAKYHIPANTPYIRYFVSYVIQFQFHKAACEAAGHTGPLHKCSIYNSTAAGGKLGAMLKLGKSKPWPQALKAMTGTEEMDVGPLTEYFKPLITWMKAQRAKHGYPIGW 596
BLAST of Angiotensin-converting enzyme vs. Ensembl Nematostella
Match: EDO35659 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKY7]) HSP 1 Score: 336.265 bits (861), Expect = 3.070e-102 Identity = 176/517 (34.04%), Postives = 287/517 (55.51%), Query Frame = 2
Query: 419 SKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKAR--PCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENG-IQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQ------IFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
S R +++T + S D +V K + ++ +++ IY + + LS + + + + ++Y+ L W WR TG ++R LY L + AKENG N ++ + ++ +N ++ L++++ P+Y++LHAYVRY L++ Y + TGPIPAH+ G++WAQ+W+NI+ II+ P+ ++ + ++K V Q + + ES + +G+ + F+E+S+ KP R V CH+S+ DF D R+K C+ T +Y HHE+GHIQY++ Y P YR AN F E +GDT++LS+ T + L+ IGLL + +I+ LM +AL V F+PF + + +++G + + N WWKL YQGIKPP+ RTE +FDPG+KYHI PYIR+FVS +L+FQF ++ CE PLH C++Y S G L +++ G+ KPW ++ + + SL +F PL+ WL + +GW
Sbjct: 560 SNDTRRQIKMVTETASSSDKDVQKTLNDVEGKMDQIYGSGKVIDTDGSKLSL-DPHLYKILSNSRDYERLKFVWKGWRDATGPELRPLYKQFVELANKGAKENGWADNGEWWRSW--YEIDNLESSVEALYEDLRPLYEELHAYVRYKLSKKY-SQVKPTGPIPAHVFGNMWAQSWVNIYDIIE-------PYE--NQPSLDVTKTMVAQNYTQLRMVQLAESFFTSIGLKALPMSFYEKSMIVKPEGREVQCHASAWDFKINRDVRIKQCTTITHNYLVTTHHELGHIQYYLQYWDQPFEYRTGANPGFHEAVGDTLSLSVDTPTHLKLIGLLDAVSNDSKSDINALMKMALRKVAFLPFGFLIDQWRWKVFSGDITSDNYNREWWKLRTKYQGIKPPVCRTENDFDPGAKYHIPGNTPYIRYFVSFVLQFQFHKAACEAAGHQGPLHKCSIYNSTEAGKKLGDMLSLGKSKPWPLALEQMTGTRKMDVSSLKEYFKPLSDWLKSQRQEYKYTIGW 1063 HSP 2 Score: 318.161 bits (814), Expect = 1.420e-95 Identity = 170/487 (34.91%), Postives = 272/487 (55.85%), Query Frame = 2
Query: 506 KNRIEHIYNKAR---PCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDF----SNG-FDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
++ + IY+ A+ P T LS + L +N LL W WR+ TG ++R L+ D L Q AK+NG QN+ ++ ++ N E + ++ + +Y +LHAYVR L+E YP + IPAH+LG++WAQNW+NI+P+++ S + + N + + ++ + E+ + +G ++ F+ +S+F KP DR V CH+++ DF S G D R+K C++ T HHEMGHI YF+ Y P +YR AN AF E +GDT+ALS+ T L K+ LL + + EI+ LM +AL + F+PF + + +Y G + +S N WW+L +QG++PPI R E FDPGSK+HIA YI++F+S +L+FQ +++C++ EPLH C++Y S G L +++ G+ KPWR+ ++ + D+ + L +F PL QWL++ +GW
Sbjct: 7 ESEMTEIYSSAKVTNPAIGTNLSLNPQ-LTELMANSRNSPELLAAWRDWRQVTGPKMRPLFKDCVTLANQGAKDNGFQNMYEYQTHL-YELPNLEEYIDGIWQELKVLYLELHAYVRQRLSEQYPHVLSSQA-IPAHLLGNMWAQNWVNIYPLVEPYSGKPS---LDVTKNLRQQNYTAVKMVQLAEAFFRSIGFEKLPGSFYSKSMFEKPEDREVLCHAAALDFFEKNSKGEKDVRIKQCTEITHQDLIITHHEMGHIYYFLKYWDQPYIYRDGANPAFHEALGDTIALSVDTPRHLVKVKLLDEYMEDKEAEINALMKMALSKIAFLPFGYLLEKWRWQVYTGEIDSSEYNKKWWELRVKHQGVRPPISRDETTFDPGSKFHIAANARYIQYFLSRILQFQLHKTVCDIAGINEPLHKCSIYNSTKAGQKLSAMLEMGRSKPWRDTLEAFTGSRDMSVNPLKEYFHPLYQWLVEQRCQNKYKIGW 487
BLAST of Angiotensin-converting enzyme vs. Ensembl Nematostella
Match: EDO28297 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T6V7]) HSP 1 Score: 211.46 bits (537), Expect = 8.529e-63 Identity = 124/354 (35.03%), Postives = 185/354 (52.26%), Query Frame = 2
Query: 881 NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
+ +GPIPAH+LG++WAQNW I+ ++ Q + P V + + ++FK +S +V +G+ M FW +S+ KP ++ V CH+S+ DF D R+KMC++ IHHEMGH +YF+AY+ P YR AN F E IGDT+ALS+ T L +GLL +PK + I++LM AL +V +PF Y R + L H Y I + F I + Y R+FVS +L+FQF +LC + K PLH C++YQSK G E++ G+ +PW + + + ++ +D LL +FAPL +WL N +GW
Sbjct: 2 SGSGPIPAHLLGNMWAQNWDGIYDMV-QPYPDATPLDV--TPSLIKQHYTPEKMFKLAQSFFVSIGLDPMPKSFWNKSMLRKPGNKSVVCHASAFDFLKD-DVRIKMCTRLKQEDLITIHHEMGHCEYFLAYKDQPYAYRNGANPGFHEAIGDTIALSVVTPKHLNSVGLLYTLPKGDEASINFLMTQALSHVAPLPFTF-------DFY-------RHDFIDITLFHRYDFI-------DMTF-------IDMTLLY-RYFVSLILQFQFHRALCNLVKHTGPLHECSIYQSKEAGKKFKEMLAAGRSRPWPQTLFKLTGEREMSADPLLEYFAPLRKWLFNYRIKNNYTLGW 322
BLAST of Angiotensin-converting enzyme vs. Ensembl Medaka
Match: ENSORLT00000005403.2 (angiotensin-converting enzyme-like [Source:NCBI gene;Acc:111946416]) HSP 1 Score: 345.125 bits (884), Expect = 4.193e-109 Identity = 171/449 (38.08%), Postives = 263/449 (58.57%), Query Frame = 2
Query: 605 KNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
++Y+ LL W W GV ++ LY L +A++ +G + ++ D E F + + L+ + P+Y LHA+VR L Y ++ N GPIPAH+LG++WAQ W NI+ ++ P V +V ++ + N +F+ E + +G+ +M EFWE S+ KPNDR V CH+S+ DF N DFR+K C+K T+ F +HHEMGHIQY++ Y++ P+ +R AN F E IGD MALS+ T L KI L+ + + +++L+ +AL+ + F+PF + ++ +++ P R N+ WW L YQGI PPI RTEE FDPG+K+HI PYIR+FVS +L+FQ E LCE PLH C +Y+SK G++L +I++ G +PW E+++ I + SL+++F P+ +WL K N +N +GW
Sbjct: 94 RSYNLLLFTWEAWHNTAGVPLKKLYSRFVELSNKASRADGFADTGAWWRSWDDDSETFEQDMDNLYKTIQPLYLHLHAFVRRKLYNQYGSKYINLKGPIPAHLLGNMWAQTWNNIYDLMIPF-----PGKVNVDVTDEMVRQGYNATHMFRVAEEFFTSLGLMEMPKEFWEGSMIVKPNDRDVVCHASAWDFYNRKDFRIKQCTKVTMDEFFTVHHEMGHIQYYLQYKNQPVGFRDGANPGFHEAIGDLMALSVSTPKHLHKINLMKSAESDEETNLNFLLNMALQKIAFLPFGYLVDLWRWGVFSEKTPPERYNADWWYLRTKYQGICPPIRRTEEQFDPGAKFHIPNNTPYIRYFVSFILQFQLHEKLCEAANHTGPLHTCDIYRSKEAGTILKKILEPGSSRPWPELLQETIGTNKIDASSLMKYFDPVIRWLEKQN--VNETLGW 535
BLAST of Angiotensin-converting enzyme vs. Ensembl Medaka
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:101172772]) HSP 1 Score: 352.443 bits (903), Expect = 1.901e-106 Identity = 177/485 (36.49%), Postives = 286/485 (58.97%), Query Frame = 2
Query: 503 IKNRIEHIYNKARPCYKTCLS-AGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNI-ASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
I + + IY+ A+ + +S + E + + ++Y+ LL W WR E+GV ++ LY L +A++ +G + A ++ + ++ E F + + KL+ + P+Y LHA+VR L + Y ++ N GPIPAH+LG++WAQ W NI+ ++ N +V ++ + N +F+ E + +G+ +M EFWE S+ KP+DR V CH+S+ DF N DFR+K C+ T+ +HHEMGHIQY++ Y+ P+ +R AN F E IGD ++LS+ T L I LL + + +I+YL+ +ALE + F+PF + ++ ++NG P + NS WW L +QGI PP +R+EE+FDPG+KYHI PYIR+FVS +L+FQF E LCE K PLH C +Y+S G +L ++++ G KPW E+++ ++ ++SLL++F P+ +WL + N +N +GW
Sbjct: 163 ILSNMSRIYSTAKVHPQPNVSWSLERELKEIMAKSRSYEKLLFVWEAWRNESGVPLKQLYTRFVELSNKASRADGFADTGADWRSW--YESETFEQDMDKLYKTLQPLYLHLHAFVRRKLYDLYGSKYINLKGPIPAHLLGNMWAQTWNNIYDLMIPFPNKPN-----LDVTDEMVRQGYNATHMFRVSEEFFTSLGLLEMPTEFWEGSMIVKPDDREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHIQYYLQYKDQPVGFRRGANPGFHEAIGDVLSLSVSTPKHLHTINLLESAASDTETDINYLLKMALEKIAFLPFGYLIDLWRWGVFNGRTPPEKYNSEWWYLRTKFQGICPPTKRSEEHFDPGAKYHIPGNTPYIRYFVSFILQFQFHEKLCEAAKHTGPLHTCDIYRSAEAGEILRKVLQAGSSKPWPEVLQEAIGTREMNANSLLKYFEPVIKWLEEQN--VNETLGW 638 HSP 2 Score: 350.517 bits (898), Expect = 9.187e-106 Identity = 203/624 (32.53%), Postives = 325/624 (52.08%), Query Frame = 2
Query: 116 KFAEKESINSDYEVFDSFYWLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDN--LMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITT-SVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAG-ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGI-QNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIF----PIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
K+ E++++N D F W+ P+ E YP+ E A+ L + N N ++Y T+IT N ML ++ + L A+ + F ++ + ++ ++ PE + + + +E Y+ A C + + + + ++Y+ LL W WR G +R Y L +AA +G N A ++ ++ F E L L+ + P+Y+ +HAYVR L +Y P N GPIPAH+LG++WAQ W I P + P + N ++F+ + + +G+ M EFWE+S+ KP+D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH+QYF+ Y+ P+ +R AN F E IGD +ALS+ T L+ IGLL + + ++ +I++LM +AL+ + F+PF + + +++G +P + N WW L YQG+ PP+ RTEE+FDPG+K+HI +PY+R+FVS +++FQF ++LCE PLH C +YQSK G LL ++MK G KPW E + II + + L+++F PL QWL + N+M +GW
Sbjct: 625 KWLEEQNVNETLGWPD-FGWVPPVPEGYPEDIEKNTDELDAKRLLDEYNTTAEEVWNAYTEASWKYNTDITDANKQAMLNRSLEMSAHTLKYGLK--AREYDTTDFQDPLVKRVIAKLSDIERAALPPEELEEYNTLLSNMETKYSVAEVCREDGRCHPLDPDLQKIMAESRDYNELLFAWKGWRDAAGKVLRQDYERYVELANKAAVLDGYSDNGAMWRSL--YETPTFEEDLESLWMELQPLYQNVHAYVRRALYKKYGPQHINLKGPIPAHLLGNMWAQTWSGIMDFAIPYPGATQVDATPAMLAQGWN-------ATRMFQESDRFFTSLGLLPMPEEFWEKSMLEKPSDGRQVVCHASAWDFYNRKDFRIKQCTVVTMDDLITVHHEMGHVQYFLQYKDQPVSFRDGANPGFHEAIGDVLALSVSTPKHLKSIGLLDKVEENYESDINFLMSMALDKIAFLPFGYLMDQWRWKVFDGRIPPNEYNKEWWNLRLKYQGLCPPVARTEEDFDPGAKFHIPANVPYVRYFVSFIIQFQFHKALCEAANHNGPLHTCDIYQSKEAGKLLSDVMKLGSSKPWPEAMAIITGQSKMSAQPLMQYFEPLIQWLQRENQMNGDVIGW 1236
BLAST of Angiotensin-converting enzyme vs. Ensembl Medaka
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:101172772]) HSP 1 Score: 349.747 bits (896), Expect = 4.295e-106 Identity = 203/624 (32.53%), Postives = 326/624 (52.24%), Query Frame = 2
Query: 116 KFAEKESINSDYEVFDSFYWLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDN--LMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAG-ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGI-QNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIF----PIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
K+ E++++N D F W+ P+ E YP+ E A+ L + N N ++Y T+IT N ML ++ + L A+ + F ++ + ++ ++ + PE + + + +E Y+ A C + + + + ++Y+ LL W WR G +R Y L +AA +G N A ++ ++ F E L L+ + P+Y+ +HAYVR L +Y P N GPIPAH+LG++WAQ W I P + P + N ++F+ + + +G+ M EFWE+S+ KP+D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH+QYF+ Y+ P+ +R AN F E IGD +ALS+ T L+ IGLL + + ++ +I++LM +AL+ + F+PF + + +++G +P + N WW L YQG+ PP+ RTEE+FDPG+K+HI +PY+R+FVS +++FQF ++LCE PLH C +YQSK G LL ++MK G KPW E + II + + L+++F PL QWL + N+M +GW
Sbjct: 521 KWLEEQNVNETLGWPD-FGWVPPVPEGYPEDIEKNTDELDAKRLLDEYNTTAEEVWNAYTEASWKYNTDITDANKQAMLNRSLEMSAHTLKYGLK--AREYDTTDFQDPLVKRVIAKLSDIERAALPPEELEEYNTLLSNMETKYSVAEVCREDGRCHPLDPDLQKIMAESRDYNELLFAWKGWRDAAGKVLRQDYERYVELANKAAVLDGYSDNGAMWRSL--YETPTFEEDLESLWMELQPLYQNVHAYVRRALYKKYGPQHINLKGPIPAHLLGNMWAQTWSGIMDFAIPYPGATQVDATPAMLAQGWN-------ATRMFQESDRFFTSLGLLPMPEEFWEKSMLEKPSDGRQVVCHASAWDFYNRKDFRIKQCTVVTMDDLITVHHEMGHVQYFLQYKDQPVSFRDGANPGFHEAIGDVLALSVSTPKHLKSIGLLDKVEENYESDINFLMSMALDKIAFLPFGYLMDQWRWKVFDGRIPPNEYNKEWWNLRLKYQGLCPPVARTEEDFDPGAKFHIPANVPYVRYFVSFIIQFQFHKALCEAANHNGPLHTCDIYQSKEAGKLLSDVMKLGSSKPWPEAMAIITGQSKMSAQPLMQYFEPLIQWLQRENQMNGDVIGW 1132 HSP 2 Score: 346.665 bits (888), Expect = 5.711e-105 Identity = 176/492 (35.77%), Postives = 288/492 (58.54%), Query Frame = 2
Query: 482 VFKRIIKIKNRIEHIYNKARPCYKTCLS-AGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNI-ASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
+F + I + ++ IY+ A+ + +S + E + ++ T ++Y LL W W +GV ++ LY + L +A++ +G + A ++ + ++ E F + + L+ + P+Y LHA+VR L Y ++ N GPIPAH+LG++WAQ W NI+ ++ N +V ++ + N +F+ E + +G+ +M EFWE S+ KP+DR V CH+S+ DF N DFR+K C+ T+ +HHEMGHIQY++ Y+ P+ +R AN F E IGD ++LS+ T L I LL + + +I+YL+ +ALE + F+PF + ++ ++NG P + NS WW L +QGI PP +R+EE+FDPG+KYHI PYIR+FVS +L+FQF E LCE K PLH C +Y+S G +L ++++ G KPW E+++ ++ ++SLL++F P+ +WL + N +N +GW
Sbjct: 52 LFLKYNTILSTMDSIYSTAKVYPQPNVSWSLEPELTDIMATSRSYKKLLFAWDGWHNASGVPLKKLYPEFVELSNKASQADGFADTGADWRSW--YESETFEQDIDNLYKTIEPLYLHLHAFVRRKLYNQYGSKYINLKGPIPAHLLGNMWAQTWNNIYDLMIPFPNKPN-----LDVTDEMVRQGYNATHMFRVSEEFFTSLGLLEMPTEFWEGSMIVKPDDREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHIQYYLQYKDQPVGFRRGANPGFHEAIGDVLSLSVSTPKHLHTINLLESAASDTETDINYLLKMALEKIAFLPFGYLIDLWRWGVFNGRTPPEKYNSEWWYLRTKFQGICPPTKRSEEHFDPGAKYHIPGNTPYIRYFVSFILQFQFHEKLCEAAKHTGPLHTCDIYRSAEAGEILRKVLQAGSSKPWPEVLQEAIGTREMNANSLLKYFEPVIKWLEEQN--VNETLGW 534
BLAST of Angiotensin-converting enzyme vs. Ensembl Medaka
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:101172772]) HSP 1 Score: 349.747 bits (896), Expect = 4.295e-106 Identity = 203/624 (32.53%), Postives = 326/624 (52.24%), Query Frame = 2
Query: 116 KFAEKESINSDYEVFDSFYWLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDN--LMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKS-VDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAG-ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGI-QNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIF----PIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
K+ E++++N D F W+ P+ E YP+ E A+ L + N N ++Y T+IT N ML ++ + L A+ + F ++ + ++ ++ + PE + + + +E Y+ A C + + + + ++Y+ LL W WR G +R Y L +AA +G N A ++ ++ F E L L+ + P+Y+ +HAYVR L +Y P N GPIPAH+LG++WAQ W I P + P + N ++F+ + + +G+ M EFWE+S+ KP+D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH+QYF+ Y+ P+ +R AN F E IGD +ALS+ T L+ IGLL + + ++ +I++LM +AL+ + F+PF + + +++G +P + N WW L YQG+ PP+ RTEE+FDPG+K+HI +PY+R+FVS +++FQF ++LCE PLH C +YQSK G LL ++MK G KPW E + II + + L+++F PL QWL + N+M +GW
Sbjct: 521 KWLEEQNVNETLGWPD-FGWVPPVPEGYPEDIEKNTDELDAKRLLDEYNTTAEEVWNAYTEASWKYNTDITDANKQAMLNRSLEMSAHTLKYGLK--AREYDTTDFQDPLVKRVIAKLSDIERAALPPEELEEYNTLLSNMETKYSVAEVCREDGRCHPLDPDLQKIMAESRDYNELLFAWKGWRDAAGKVLRQDYERYVELANKAAVLDGYSDNGAMWRSL--YETPTFEEDLESLWMELQPLYQNVHAYVRRALYKKYGPQHINLKGPIPAHLLGNMWAQTWSGIMDFAIPYPGATQVDATPAMLAQGWN-------ATRMFQESDRFFTSLGLLPMPEEFWEKSMLEKPSDGRQVVCHASAWDFYNRKDFRIKQCTVVTMDDLITVHHEMGHVQYFLQYKDQPVSFRDGANPGFHEAIGDVLALSVSTPKHLKSIGLLDKVEENYESDINFLMSMALDKIAFLPFGYLMDQWRWKVFDGRIPPNEYNKEWWNLRLKYQGLCPPVARTEEDFDPGAKFHIPANVPYVRYFVSFIIQFQFHKALCEAANHNGPLHTCDIYQSKEAGKLLSDVMKLGSSKPWPEAMAIITGQSKMSAQPLMQYFEPLIQWLQRENQMNGDVIGW 1132 HSP 2 Score: 346.665 bits (888), Expect = 5.711e-105 Identity = 176/492 (35.77%), Postives = 288/492 (58.54%), Query Frame = 2
Query: 482 VFKRIIKIKNRIEHIYNKARPCYKTCLS-AGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNI-ASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
+F + I + ++ IY+ A+ + +S + E + ++ T ++Y LL W W +GV ++ LY + L +A++ +G + A ++ + ++ E F + + L+ + P+Y LHA+VR L Y ++ N GPIPAH+LG++WAQ W NI+ ++ N +V ++ + N +F+ E + +G+ +M EFWE S+ KP+DR V CH+S+ DF N DFR+K C+ T+ +HHEMGHIQY++ Y+ P+ +R AN F E IGD ++LS+ T L I LL + + +I+YL+ +ALE + F+PF + ++ ++NG P + NS WW L +QGI PP +R+EE+FDPG+KYHI PYIR+FVS +L+FQF E LCE K PLH C +Y+S G +L ++++ G KPW E+++ ++ ++SLL++F P+ +WL + N +N +GW
Sbjct: 52 LFLKYNTILSTMDSIYSTAKVYPQPNVSWSLEPELTDIMATSRSYKKLLFAWDGWHNASGVPLKKLYPEFVELSNKASQADGFADTGADWRSW--YESETFEQDIDNLYKTIEPLYLHLHAFVRRKLYNQYGSKYINLKGPIPAHLLGNMWAQTWNNIYDLMIPFPNKPN-----LDVTDEMVRQGYNATHMFRVSEEFFTSLGLLEMPTEFWEGSMIVKPDDREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHIQYYLQYKDQPVGFRRGANPGFHEAIGDVLSLSVSTPKHLHTINLLESAASDTETDINYLLKMALEKIAFLPFGYLIDLWRWGVFNGRTPPEKYNSEWWYLRTKFQGICPPTKRSEEHFDPGAKYHIPGNTPYIRYFVSFILQFQFHEKLCEAAKHTGPLHTCDIYRSAEAGEILRKVLQAGSSKPWPEVLQEAIGTREMNANSLLKYFEPVIKWLEEQN--VNETLGW 534
BLAST of Angiotensin-converting enzyme vs. Ensembl Medaka
Match: ace (angiotensin I converting enzyme [Source:NCBI gene;Acc:101172772]) HSP 1 Score: 350.903 bits (899), Expect = 5.241e-106 Identity = 203/624 (32.53%), Postives = 325/624 (52.08%), Query Frame = 2
Query: 116 KFAEKESINSDYEVFDSFYWLTPL-EYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDN--LMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITT-SVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAG-ESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGI-QNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCL-AEYYPDRFNKTGPIPAHILGDVWAQNWINIF----PIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPND-RIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
K+ E++++N D F W+ P+ E YP+ E A+ L + N N ++Y T+IT N ML ++ + L A+ + F ++ + ++ ++ PE + + + +E Y+ A C + + + + ++Y+ LL W WR G +R Y L +AA +G N A ++ ++ F E L L+ + P+Y+ +HAYVR L +Y P N GPIPAH+LG++WAQ W I P + P + N ++F+ + + +G+ M EFWE+S+ KP+D R V CH+S+ DF N DFR+K C+ T+ +HHEMGH+QYF+ Y+ P+ +R AN F E IGD +ALS+ T L+ IGLL + + ++ +I++LM +AL+ + F+PF + + +++G +P + N WW L YQG+ PP+ RTEE+FDPG+K+HI +PY+R+FVS +++FQF ++LCE PLH C +YQSK G LL ++MK G KPW E + II + + L+++F PL QWL + N+M +GW
Sbjct: 601 KWLEEQNVNETLGWPD-FGWVPPVPEGYPEDIEKNTDELDAKRLLDEYNTTAEEVWNAYTEASWKYNTDITDANKQAMLNRSLEMSAHTLKYGLK--AREYDTTDFQDPLVKRVIAKLSDIERAALPPEELEEYNTLLSNMETKYSVAEVCREDGRCHPLDPDLQKIMAESRDYNELLFAWKGWRDAAGKVLRQDYERYVELANKAAVLDGYSDNGAMWRSL--YETPTFEEDLESLWMELQPLYQNVHAYVRRALYKKYGPQHINLKGPIPAHLLGNMWAQTWSGIMDFAIPYPGATQVDATPAMLAQGWN-------ATRMFQESDRFFTSLGLLPMPEEFWEKSMLEKPSDGRQVVCHASAWDFYNRKDFRIKQCTVVTMDDLITVHHEMGHVQYFLQYKDQPVSFRDGANPGFHEAIGDVLALSVSTPKHLKSIGLLDKVEENYESDINFLMSMALDKIAFLPFGYLMDQWRWKVFDGRIPPNEYNKEWWNLRLKYQGLCPPVARTEEDFDPGAKFHIPANVPYVRYFVSFIIQFQFHKALCEAANHNGPLHTCDIYQSKEAGKLLSDVMKLGSSKPWPEAMAIITGQSKMSAQPLMQYFEPLIQWLQRENQMNGDVIGW 1212 HSP 2 Score: 347.436 bits (890), Expect = 8.714e-105 Identity = 175/485 (36.08%), Postives = 285/485 (58.76%), Query Frame = 2
Query: 503 IKNRIEHIYNKARPCYKTCLS-AGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNI-ASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRF-NKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVN--QIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
I + ++ IY+ A+ + +S + E + ++ T ++Y LL W W +GV ++ LY + L +A++ +G + A ++ + ++ E F + + L+ + P+Y LHA+VR L Y ++ N GPIPAH+LG++WAQ W NI+ ++ N +V ++ + N +F+ E + +G+ +M EFWE S+ KP+DR V CH+S+ DF N DFR+K C+ T+ +HHEMGHIQY++ Y+ P+ +R AN F E IGD ++LS+ T L I LL + + +I+YL+ +ALE + F+PF + ++ ++NG P + NS WW L +QGI PP +R+EE+FDPG+KYHI PYIR+FVS +L+FQF E LCE K PLH C +Y+S G +L ++++ G KPW E+++ ++ ++SLL++F P+ +WL + N +N +GW
Sbjct: 139 ILSTMDSIYSTAKVYPQPNVSWSLEPELTDIMATSRSYKKLLFAWDGWHNASGVPLKKLYPEFVELSNKASQADGFADTGADWRSW--YESETFEQDIDNLYKTIEPLYLHLHAFVRRKLYNQYGSKYINLKGPIPAHLLGNMWAQTWNNIYDLMIPFPNKPN-----LDVTDEMVRQGYNATHMFRVSEEFFTSLGLLEMPTEFWEGSMIVKPDDREVVCHASAWDFYNRKDFRIKQCTTVTMEQLFTVHHEMGHIQYYLQYKDQPVGFRRGANPGFHEAIGDVLSLSVSTPKHLHTINLLESAASDTETDINYLLKMALEKIAFLPFGYLIDLWRWGVFNGRTPPEKYNSEWWYLRTKFQGICPPTKRSEEHFDPGAKYHIPGNTPYIRYFVSFILQFQFHEKLCEAAKHTGPLHTCDIYRSAEAGEILRKVLQAGSSKPWPEVLQEAIGTREMNANSLLKYFEPVIKWLEEQN--VNETLGW 614
BLAST of Angiotensin-converting enzyme vs. Planmine SMEST
Match: SMESG000005712.1 (SMESG000005712.1) HSP 1 Score: 1310.82 bits (3391), Expect = 0.000e+0 Identity = 630/633 (99.53%), Postives = 632/633 (99.84%), Query Frame = 2
Query: 44 MFLKCQNLIFLIFIITDANETDSNKFAEKESINSDYEVFDSFYWLTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
MFLKCQNLIFLIFIITD+NETDSNKFAEKESINSDYEVFDSFYWLTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQF+SKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNK IEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW
Sbjct: 1 MFLKCQNLIFLIFIITDSNETDSNKFAEKESINSDYEVFDSFYWLTPLEYYPDSCLSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFYSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKGIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 633
BLAST of Angiotensin-converting enzyme vs. Planmine SMEST
Match: SMESG000005698.1 (SMESG000005698.1) HSP 1 Score: 667.537 bits (1721), Expect = 0.000e+0 Identity = 299/602 (49.67%), Postives = 440/602 (73.09%), Query Frame = 2
Query: 152 EVFDSFYWLTPLEYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNN--NPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
++FDS++ LT LE YP+ C +E CA++WL+KVNEI IRN+NR AN+ YRY +NI NL LL +F+I K N++ AK F W++F S +R++ + ++ +V+S D + + ++++K++IE+IYN +PC+ CL AGE I++LF EK+YD L GYW+ WR TG +IR+L++ + LE A+ENG ++ASF +FEDF+EENF ET+++L++ ++P+YK+LH++VRYCL +YYP +F+K GPIPAHI G+VW+Q W NIF I+K+C ++N N FH + + KL K+SV ++F+ E Y +G+++MTNEFWERS+ + R++DCH S+ DF+NG D+R+ MC+KK ++ F+ IHHEMGHI+YFMAY LP YR SANS F E IGDT+AL++KT L KIGLL IPK+ + +I+YLM ALE V F+PFA+ ++ S+YNG++P+S++N YWW L YQGIKPP+ER+E++FD G+KYHIAF +PYIR+F+S +++FQF+ES+C+++ PLH C YQS G+ L+E++K G++ WRE +KI+ ++I+S SLL+FF PL WL N+ L+ VGW
Sbjct: 11 QIFDSYHNLTELEDYPEVCEEYSNENCAKSWLIKVNEITIRNDNRYANLNYRYGSNINKTNLELLKKFQIIYGKLGNSIQLKAKKFQWKRFSSPNVRKILDKLSKTVRSQDENISRNLVEVKSKIEYIYNNGKPCFGICLPAGEPAIIDLFKKEKDYDKLTGYWVAWRNVTGARIRNLFVKKVELENLGARENGFSDLASFILFEDFEEENFKETVIQLYEGILPLYKELHSFVRYCLWKYYPGKFDKNGPIPAHIFGNVWSQQWTNIFEIVKKCMKSNYQNDFH--EQASAKLEKLSVRKMFEMAEEFYNSIGLFKMTNEFWERSVVEQIPGRLIDCHGSAHDFANGVDYRILMCTKKDLNDFTTIHHEMGHIEYFMAYSKLPTFYRNSANSGFHEAIGDTIALAVKTPEHLHKIGLLPEIPKSKEFDIEYLMGSALEKVAFLPFALKMDSYIWSVYNGTIPSSKLNEYWWDLSLKYQGIKPPVERSEKDFDAGAKYHIAFSVPYIRYFISFIIQFQFYESMCDLSGYKGPLHRCDFYQSHKAGNKLLEMLKQGEKNNWRETMKILTGTKEIKSGSLLKFFEPLHVWLKHKNRDLHNRVGW 610
BLAST of Angiotensin-converting enzyme vs. Planmine SMEST
Match: SMESG000005698.1 (SMESG000005698.1) HSP 1 Score: 667.152 bits (1720), Expect = 0.000e+0 Identity = 299/602 (49.67%), Postives = 440/602 (73.09%), Query Frame = 2
Query: 152 EVFDSFYWLTPLEYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNN--NPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
++FDS++ LT LE YP+ C +E CA++WL+KVNEI IRN+NR AN+ YRY +NI NL LL +F+I K N++ AK F W++F S +R++ + ++ +V+S D + + ++++K++IE+IYN +PC+ CL AGE I++LF EK+YD L GYW+ WR TG +IR+L++ + LE A+ENG ++ASF +FEDF+EENF ET+++L++ ++P+YK+LH++VRYCL +YYP +F+K GPIPAHI G+VW+Q W NIF I+K+C ++N N FH + + KL K+SV ++F+ E Y +G+++MTNEFWERS+ + R++DCH S+ DF+NG D+R+ MC+KK ++ F+ IHHEMGHI+YFMAY LP YR SANS F E IGDT+AL++KT L KIGLL IPK+ + +I+YLM ALE V F+PFA+ ++ S+YNG++P+S++N YWW L YQGIKPP+ER+E++FD G+KYHIAF +PYIR+F+S +++FQF+ES+C+++ PLH C YQS G+ L+E++K G++ WRE +KI+ ++I+S SLL+FF PL WL N+ L+ VGW
Sbjct: 31 QIFDSYHNLTELEDYPEVCEEYSNENCAKSWLIKVNEITIRNDNRYANLNYRYGSNINKTNLELLKKFQIIYGKLGNSIQLKAKKFQWKRFSSPNVRKILDKLSKTVRSQDENISRNLVEVKSKIEYIYNNGKPCFGICLPAGEPAIIDLFKKEKDYDKLTGYWVAWRNVTGARIRNLFVKKVELENLGARENGFSDLASFILFEDFEEENFKETVIQLYEGILPLYKELHSFVRYCLWKYYPGKFDKNGPIPAHIFGNVWSQQWTNIFEIVKKCMKSNYQNDFH--EQASAKLEKLSVRKMFEMAEEFYNSIGLFKMTNEFWERSVVEQIPGRLIDCHGSAHDFANGVDYRILMCTKKDLNDFTTIHHEMGHIEYFMAYSKLPTFYRNSANSGFHEAIGDTIALAVKTPEHLHKIGLLPEIPKSKEFDIEYLMGSALEKVAFLPFALKMDSYIWSVYNGTIPSSKLNEYWWDLSLKYQGIKPPVERSEKDFDAGAKYHIAFSVPYIRYFISFIIQFQFYESMCDLSGYKGPLHRCDFYQSHKAGNKLLEMLKQGEKNNWRETMKILTGTKEIKSGSLLKFFEPLHVWLKHKNRDLHNRVGW 630
BLAST of Angiotensin-converting enzyme vs. Planmine SMEST
Match: SMESG000005704.1 (SMESG000005704.1) HSP 1 Score: 665.226 bits (1715), Expect = 0.000e+0 Identity = 298/602 (49.50%), Postives = 439/602 (72.92%), Query Frame = 2
Query: 152 EVFDSFYWLTPLEYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNN--NPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
++FDS++ LT LE YP+ C +E CA++WL+KVNEI IRN+NR AN+ YRY +NI NL LL +F+I K N++ AK F W++F S +R++ + ++ +V+S D + + ++++K++IE+IYN +PC+ CL AGE I++LF EK+YD L GYW+ WR TG +IR+L++ + LE A+ENG ++ASF +FEDF+EENF ET+++L++ ++P+YK+LH++VRYCL +YYP +F+K GPIPAHI G+VW+Q W NIF I+K+C ++N N FH + + KL K+SV ++F+ E Y +G+++MTNEFWERS+ + R++DCH S+ DF+NG D+R+ MC+KK ++ F+ IHHEMGHI+YFMAY LP YR SANS F E IGDT+AL++KT L KIGLL IPK+ + +I+YLM ALE V F+PFA+ ++ S+YNG++P+S++N YWW L YQGIKPP+ER+E++FD G+KYHIAF +PYIR+F+S +++FQF+ES+C+++ PLH C YQS G+ L+E++K G++ WRE +K + ++I+S SLL+FF PL WL N+ L+ VGW
Sbjct: 27 QIFDSYHNLTELEDYPEVCEEYSNENCAKSWLIKVNEITIRNDNRYANLNYRYGSNINKTNLELLKKFQIIYGKLGNSIQLKAKKFQWKRFSSPNVRKILDKLSKTVRSQDENISRNLVEVKSKIEYIYNNGKPCFGICLPAGEPAIIDLFKKEKDYDKLTGYWVAWRNVTGARIRNLFVKKVELENLGARENGFSDLASFILFEDFEEENFKETVIQLYEGILPLYKELHSFVRYCLWKYYPGKFDKNGPIPAHIFGNVWSQKWTNIFEIVKKCMKSNYQNNFH--EQASAKLEKLSVRKMFEMAEEFYNSIGLFKMTNEFWERSVVEQIPGRLIDCHGSAHDFANGVDYRILMCTKKDLNDFTTIHHEMGHIEYFMAYSKLPTFYRNSANSGFHEAIGDTIALAVKTPEHLHKIGLLPEIPKSKEFDIEYLMGSALEKVAFLPFALKMDSYIWSVYNGTIPSSKLNEYWWDLSLKYQGIKPPVERSEKDFDAGAKYHIAFSVPYIRYFISFIIQFQFYESMCDLSGYKGPLHRCDFYQSHKAGNKLLEMLKQGKKNNWRETMKTLTGTKEIKSGSLLKFFEPLHVWLKHKNRDLHNRVGW 626
BLAST of Angiotensin-converting enzyme vs. Planmine SMEST
Match: SMESG000005710.1 (SMESG000005710.1) HSP 1 Score: 658.677 bits (1698), Expect = 0.000e+0 Identity = 306/637 (48.04%), Postives = 435/637 (68.29%), Query Frame = 2
Query: 65 LIFLIFIITDANETDSNKFAE-KESINSDYE-------VFDSFYWLTPLEYYPDSC---LSETCAENWLVKVNEIMIRNENRIANVYYRYATNITSDNLMLLNQFRITKVKYENNLISIAKGFPWQQFHSKKMREMFEIITTSVKSVDPEVFKRIIKIKNRIEHIYNKARPCYKTCLSAGESGIVNLFNTEKNYDTLLGYWIVWRKETGVQIRDLYIDRFNLEIQAAKENGIQNIASFKMFEDFQEENFLETLMKLFDNVMPIYKQLHAYVRYCLAEYYPDRFNKTGPIPAHILGDVWAQNWINIFPIIKQCSRNNNPFHVFHEVNFKLSKMSVNQIFKTVESNYVGMGMYQMTNEFWERSLFTKPNDRIVDCHSSSEDFSNGFDFRVKMCSKKTVSYFSAIHHEMGHIQYFMAYQHLPILYRASANSAFQEIIGDTMALSMKTLSSLEKIGLLSNIPKTFDLEIDYLMLLALENVPFVPFAMINSVFVNSLYNGSVPTSRMNSYWWKLVHTYQGIKPPIERTEENFDPGSKYHIAFGIPYIRHFVSSLLKFQFFESLCEMNKKIEPLHFCTLYQSKNVGSLLIEIMKNGQRKPWREIIKIINRNEDIQSDSLLRFFAPLTQWLIKTNKMLNIHVGW 1942
L LI I+ + ++ F++ K I+ D E VFDS+Y +T LE YP+ C SE CA+ W K+NEI IRN NR AN++++Y+T+I NL L +F+ K L +K F W+ F S ++R F +IT S+++ + + +I I N I +IYN A+PC+ CL GESGI+ LF TEK+Y+ L GYW WR TG +I+ L++ R LE ++ENG ++ A++ + DF++++F T +KL+ ++P+YK+LH YVRYCL ++YP +F+K+GPIPAHI G+VWAQ W NIFPII+ C + + + E LSKM V Q+F E Y +GM++MT+EFWERS+ +KP D++V+CH S+ DFSNG DFR+KMC++K + F+ IHHEMGHI+Y+MAY HLP ++R SANS F E IGDT+AL++KT L KIGL+S +P + +IDYLM ALE V F+PFA+ ++ LYNGSVP S +N +WW L + YQG+ PP++RTE++FDPGSKYHI+FG+ YIR+FVS L++FQF+ES+C ++ PLH C YQSK G L+E++ G+ + WRE +KI+ +I+S+SLL+FF PL +WL TNK LNI +GW
Sbjct: 5 LTLLIVILIQSLQSRDRFFSKTKNEIDFDDEFQALEPSVFDSYYHMTDLEGYPNVCDEYASEKCAKLWFDKINEISIRNRNRFANIHFKYSTDINKKNLELKKRFQRIGSKIGLKLKRKSKKFHWKSFKSPELRRKFRLITASIRNENESLVHELIHINNDISYIYNNAKPCFNKCLEVGESGIIKLFKTEKDYEKLAGYWTAWRNVTGQKIKKLFLRRMQLENIGSRENGHEDAATYGLSFDFEDDDFKSTALKLYGAILPLYKELHGYVRYCLNKFYPGKFDKSGPIPAHIFGNVWAQQWTNIFPIIRDCGQKLSAENYQDEATENLSKMPVEQMFTIAEEFYESIGMFKMTDEFWERSMLSKPQDKVVNCHGSAHDFSNGVDFRIKMCTEKNIVDFTTIHHEMGHIEYYMAYSHLPTIFRGSANSGFHEAIGDTIALAVKTPEHLHKIGLISRVPDSKGFDIDYLMATALEKVAFLPFALSMDSYIWGLYNGSVPLSEVNKHWWDLRYRYQGLMPPVKRTEDDFDPGSKYHISFGVSYIRYFVSFLIQFQFYESMCNISGYKGPLHRCNFYQSKEAGLKLMEMLSKGKSQNWRETMKILTGATEIKSESLLKFFDPLYKWLKFTNKKLNIPIGW 641 The following BLAST results are available for this feature:
BLAST of Angiotensin-converting enzyme vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of Angiotensin-converting enzyme vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of Angiotensin-converting enzyme vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Angiotensin-converting enzyme vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Angiotensin-converting enzyme vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Angiotensin-converting enzyme vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Angiotensin-converting enzyme vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002442 ID=SMED30002442|Name=Angiotensin-converting enzyme|organism=Schmidtea mediterranea sexual|type=transcript|length=2066bpback to top protein sequence of SMED30002442-orf-1 >SMED30002442-orf-1 ID=SMED30002442-orf-1|Name=SMED30002442-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=634bp MFLKCQNLIFLIFIITDANETDSNKFAEKESINSDYEVFDSFYWLTPLEYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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