noggin-like protein 2

Overview


Name	noggin-like protein 2 (ACO06227.1)
Smed ID	SMED30002427
Length (bp)	949

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of noggin-like protein 2 (SMED30002427) t-SNE clustered cells

Violin plots show distribution of expression levels for noggin-like protein 2 (SMED30002427) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of noggin-like protein 2 (SMED30002427) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for noggin-like protein 2 (SMED30002427) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30002427

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pigment cell	SMED30002427	SMESG000034689.1 SMESG000034679.1	SmedASXL_011775	SmedAsxl_ww_GCZZ01	PMID:29158443 He et al., 2017
enteric muscle cell	SMED30002427	SMESG000034689.1 SMESG000034679.1	dd_Smed_v4_7999_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018
parenchymal cell	SMED30002427	SMESG000034689.1 SMESG000034679.1	FJ471484.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
parenchymal cell	SMED30002427	SMESG000034689.1 SMESG000034679.1	FJ471484	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009

Note: Hover over icons to view figure legend

Homology

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BLAST of noggin-like protein 2 vs. Ensembl Human
Match: NOG (noggin [Source:HGNC Symbol;Acc:HGNC:7866])

HSP 1 Score: 67.0106 bits (162), Expect = 2.312e-12
Identity = 34/89 (38.20%), Postives = 48/89 (53.93%), Query Frame = 2

Query:  395 VKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            +K   ++    +G K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK      LT+L+W C+
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 2 vs. Ensembl Zebrafish
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 63.5438 bits (153), Expect = 1.568e-11
Identity = 37/122 (30.33%), Postives = 63/122 (51.64%), Query Frame = 2

Query:  305 FD-DWISSRIPKQIYIPFNGTKQIDV-RIQFLVKMKNYTFKDRK-GNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            FD +++S  +P Q+    N +   ++ R+    ++K     +   G ++ +       F +WL   + CP+ Y W +L   FWPR++K+G C S  SCS+P GM+CK       T L+W C+
Sbjct:   70 FDANFMSIHLPAQL----NASAPPELPRLPMPAELKKLDLTETPYGRRVKVGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFSERSCSFPEGMSCKPVKAVTKTFLRWYCQ 187

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BLAST of noggin-like protein 2 vs. Ensembl Zebrafish
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 63.5438 bits (153), Expect = 2.218e-11
Identity = 35/97 (36.08%), Postives = 48/97 (49.48%), Query Frame = 2

Query:  368 QIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            Q+++       +KN  F    G K   S  +    + WL   S CP+ Y W +L   FWPR+V+ G C +  SCS P GM CK      +TLL+W C
Sbjct:   92 QLNLAGMMPKDIKNLDFDAPWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTKRSCSVPEGMVCKPAKSTHITLLRWRC 188

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BLAST of noggin-like protein 2 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 60.077 bits (144), Expect = 3.740e-10
Identity = 31/87 (35.63%), Postives = 45/87 (51.72%), Query Frame = 2

Query:  398 KMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            ++K   F  + G K   S  +    + WL   + CP+ + W +L   FWPR++K G C +  SCS P GM CK      LT+L+W C
Sbjct:  109 EIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRC 195

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Query:  398 KMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            ++K   F  + G K   S  +    + WL   + CP+ + W +L   FWPR++K G C +  SCS P GM CK      LT+L+W C
Sbjct:  109 EIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRC 195

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 60.077 bits (144), Expect = 3.849e-10
Identity = 31/87 (35.63%), Postives = 45/87 (51.72%), Query Frame = 2

Query:  398 KMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            ++K   F  + G K   S  +    + WL   + CP+ + W +L   FWPR++K G C +  SCS P GM CK      LT+L+W C
Sbjct:  109 EIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRC 195

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Xenopus
Match: nog (noggin [Source:NCBI gene;Acc:493191])

HSP 1 Score: 70.0922 bits (170), Expect = 1.501e-13
Identity = 33/82 (40.24%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  416 FKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            ++  +G K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK+     LT+L+W C+
Sbjct:  117 YEGLQGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKRSCSVPEGMVCKAAKSMHLTILRWRCQ 198

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BLAST of noggin-like protein 2 vs. Ensembl Xenopus
Match: nog4 (noggin 4 [Source:NCBI gene;Acc:733455])

HSP 1 Score: 67.781 bits (164), Expect = 1.306e-12
Identity = 29/71 (40.85%), Postives = 41/71 (57.75%), Query Frame = 2

Query:  449 SPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSV-VSCSWPPGMNCKSKHKKKLTLLQWNC 658
            S +V +  R+WL Q +SC +   W +L   FWPRWV+   C     +CSWPPGM C+     ++ LL W+C
Sbjct:  144 SLHVQNEIRQWLVQRASCQLTSTWVDLGTVFWPRWVRHTDCDGANTACSWPPGMACRQAQLTQIKLLAWHC 214

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BLAST of noggin-like protein 2 vs. Ensembl Xenopus
Match: acad10 (acyl-CoA dehydrogenase family member 10 [Source:Xenbase;Acc:XB-GENE-967980])

HSP 1 Score: 63.5438 bits (153), Expect = 3.039e-11
Identity = 29/77 (37.66%), Postives = 42/77 (54.55%), Query Frame = 2

Query:  431 GNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            G ++ +       F +WL   + CP+ Y W +L   FWPR++K+G C S  SCS+P GM CK       T L+W C+
Sbjct:  117 GGRIRMGKKARRKFLQWLWAYTYCPVMYTWKDLGVRFWPRFIKEGHCFSEKSCSFPEGMYCKPIKSVTKTFLRWYCQ 193

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BLAST of noggin-like protein 2 vs. Ensembl Mouse
Match: Nog (noggin [Source:MGI Symbol;Acc:MGI:104327])

HSP 1 Score: 67.0106 bits (162), Expect = 1.512e-12
Identity = 34/89 (38.20%), Postives = 48/89 (53.93%), Query Frame = 2

Query:  395 VKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            +K   ++    +G K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK      LT+L+W C+
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 2 vs. UniProt/SwissProt
Match: sp|O93525|NOGG_CHICK (Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 4.583e-12
Identity = 36/90 (40.00%), Postives = 49/90 (54.44%), Query Frame = 2

Query:  398 KMKNYTFKD--RKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            ++K   F D  + G K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK      LT+L+W C+
Sbjct:  110 EIKGLEFYDGLQPGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGSRFWPRYVKVGSCYSKRSCSVPEGMVCKPAKSVHLTILRWRCQ 199

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BLAST of noggin-like protein 2 vs. UniProt/SwissProt
Match: sp|P49011|NOGG_XENLA (Noggin OS=Xenopus laevis OX=8355 GN=nog PE=1 SV=1)

HSP 1 Score: 67.3958 bits (163), Expect = 7.859e-12
Identity = 32/82 (39.02%), Postives = 46/82 (56.10%), Query Frame = 2

Query:  416 FKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            ++  +  K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK+     LT+L+W C+
Sbjct:  117 YEGLQSKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKRSCSVPEGMVCKAAKSMHLTILRWRCQ 198

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BLAST of noggin-like protein 2 vs. UniProt/SwissProt
Match: sp|Q9YHT8|NOGG_TAKRU (Noggin OS=Takifugu rubripes OX=31033 GN=nog PE=3 SV=1)

HSP 1 Score: 67.3958 bits (163), Expect = 8.211e-12
Identity = 29/63 (46.03%), Postives = 39/63 (61.90%), Query Frame = 2

Query:  470 FRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
             ++WL   S CP+ + WT+L   FWPR+V+ G C+S  SCS P GM CK      LT+L+W C
Sbjct:  133 LQQWLWAYSFCPLAHAWTDLGSRFWPRFVRAGSCLSKRSCSVPEGMTCKPATSTHLTILRWRC 195

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BLAST of noggin-like protein 2 vs. UniProt/SwissProt
Match: sp|P97466|NOGG_MOUSE (Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 1.058e-11
Identity = 34/89 (38.20%), Postives = 48/89 (53.93%), Query Frame = 2

Query:  395 VKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            +K   ++    +G K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK      LT+L+W C+
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

[Close]

BLAST of noggin-like protein 2 vs. UniProt/SwissProt
Match: sp|Q13253|NOGG_HUMAN (Noggin OS=Homo sapiens OX=9606 GN=NOG PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 1.110e-11
Identity = 34/89 (38.20%), Postives = 48/89 (53.93%), Query Frame = 2

Query:  395 VKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            +K   ++    +G K  LS  +    + WL  ++ CP+ Y W +L   FWPR+VK G C S  SCS P GM CK      LT+L+W C+
Sbjct:  120 IKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 2 vs. TrEMBL
Match: C1JAC2 (Noggin-like protein 2 OS=Schmidtea mediterranea OX=79327 GN=nlg2 PE=2 SV=1)

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 279/280 (99.64%), Postives = 280/280 (100.00%), Query Frame = 2

Query:   68 MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQ+DVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE
Sbjct:    1 MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQVDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 280

[Close]

BLAST of noggin-like protein 2 vs. TrEMBL
Match: C1JAC5 (Noggin-like protein 5 OS=Schmidtea mediterranea OX=79327 GN=nlg5 PE=2 SV=1)

HSP 1 Score: 255.758 bits (652), Expect = 2.720e-80
Identity = 124/277 (44.77%), Postives = 186/277 (67.15%), Query Frame = 2

Query:   83 DLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRG--VRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            +L+ ++ LF    +   ++ +++ KPI     ++   IV VR ++       F PN++ +I K L++ILD + LFD+W++   P +IYIP NGT +ID R++ L+KMKN+ FK+++G K+ L+ +++DS + WLE+ESSC M+YIW EL+PSFWPRW+KKG+CVS+ SCSWPPGM+CK+K  K L LLQ+ CE DP K KY AD   M+ ++  R KRQ K++ R+    + R    R+V+T + KE++ K  I  LRE+++ FYCKW K  Y V E
Sbjct:   27 NLTFVVILFI---IKIGMSTKTTRKPITINLTTNEQNIVGVRFNFNEIIVTNFIPNLSPSIDKKLKKILDSDHLFDNWLALTKPAEIYIPLNGTNKIDSRLRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVSLTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVFQGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNE 300

[Close]

BLAST of noggin-like protein 2 vs. TrEMBL
Match: C1JAC3 (Noggin-like protein 3 OS=Schmidtea mediterranea OX=79327 GN=nlg3 PE=2 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 1.595e-58
Identity = 104/248 (41.94%), Postives = 155/248 (62.50%), Query Frame = 2

Query:  170 ETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKR--RGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            E +S N       + Y++P    F PN+T N  + L+QI+    L D+WIS   P Q+Y   N  + +  R++FLVKMKN T  D+ G K+ +S  ++ S ++WL +ES C ++Y W EL+ ++WPRWVKKG+CV++ SCSWPPGM+C     +KL+LLQW C  D  K KYK D + ++  ++IR KRQN  +  +  S KR  R  RK+  S+S  +K + R+ KL  + + FYCKW++V Y+VI+
Sbjct:   21 EGKSKNKDFRKFSHYYEVPSYLHF-PNITHNTRRILQQIIHNGILVDNWISITKPHQLYQSSNEPENVSKRMRFLVKMKNITLIDKNGFKINISKTILTSIQQWLIEESKCQVEYHWQELNETYWPRWVKKGLCVNIKSCSWPPGMSCSPNSYRKLSLLQWICAEDKSKEKYKDDKLLIKIARKIRRKRQNISNNSKFKSKKRWLRLPRKLEESQSNAIKIRLRLFKLSLYTEGFYCKWREVHYRVIQ 267

[Close]

BLAST of noggin-like protein 2 vs. TrEMBL
Match: T1D134 (Nlg1 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 146.747 bits (369), Expect = 1.821e-38
Identity = 76/226 (33.63%), Postives = 125/226 (55.31%), Query Frame = 2

Query:  239 FYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSK---YKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            F+P+      K L+ I+  +     W+S   P +I+   N +K     +  L   KNYT  D  GN++ +  N+  + RRW+ +++SC ++Y+W +LD   WP W+K GIC S  SCSWPPGM+C+++  KK  +L+W C  DP   K   ++   +Q+R  + +  KR++ L K+ N   +RRG+     SK  E K  +   K  +++  F+C+W+ V Y V+E
Sbjct:   38 FHPDDNSYNTKHLKAIMGGKNYDVTWMSINRPPKIFESANFSKPPSRNLLMLSNFKNYTLVDEVGNEMKIPKNISTAIRRWIVEQASCRVEYVWKKLDALHWPSWIKHGICSSKESCSWPPGMSCRNESHKKFKILKWICNSDPFAHKWNEFREKFLQLRKSRLLNRKRRHNL-KKSNLVKQRRGLNFPNRSKRDEKKRLRYAYKTSKYVQGFFCQWEPVDYSVVE 262

[Close]

BLAST of noggin-like protein 2 vs. TrEMBL
Match: A8SLH5 (Noggin-like protein 1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 124.02 bits (310), Expect = 8.077e-30
Identity = 77/216 (35.65%), Postives = 114/216 (52.78%), Query Frame = 2

Query:  275 LRQILDQEQLFDDWISSRIPKQIY----IPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRIL-KLREHIDDFYCKWKKVTYQVIE 907
            L++IL  +     W+S   P  IY    +  +  KQ+DV + F    KN +F D KG  +  S N+  + RRW+ Q+++C  DYIW  LD + WP W+K GIC S   CSWPPGM CK   KK L +L+W C  DP   K+ A    M   ++ R  R+++   +R+ S KR+   K +    +  +  KR L K  ++   + C+WK + Y V E
Sbjct:   54 LQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSF----KNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDRKRRRLRRHQF--KRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGYLCQWKPIDYTVYE 263

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Cavefish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 62.003 bits (149), Expect = 4.199e-11
Identity = 29/60 (48.33%), Postives = 34/60 (56.67%), Query Frame = 2

Query:  479 WLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            WL   + CP+ Y W +L   FWPR+VK G C S  SCS P GM C       LTLL+W C
Sbjct:  113 WLWSYTFCPVVYAWQDLGSRFWPRYVKVGSCASKRSCSVPEGMVCSPAKSAHLTLLRWYC 172

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Cavefish
Match: ENSAMXT00000051007.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000650.1:142689:143405:-1 gene:ENSAMXG00000039724.1 transcript:ENSAMXT00000051007.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.225 bits (134), Expect = 5.495e-9
Identity = 30/81 (37.04%), Postives = 41/81 (50.62%), Query Frame = 2

Query:  428 KGNKLYLSPNVVDSFRRWL---EQESS-CPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
             G+ L+         R WL   E+E + CP+   W++L   FWPR+V+ G C    SCS P GM C       +TLL+W C
Sbjct:  101 SGDHLHAGKKRKRRRRLWLREFERERALCPVVQTWSDLGARFWPRYVRMGSCSRERSCSVPAGMLCTPAASTHVTLLRWRC 181

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Sea Lamprey
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 69.3218 bits (168), Expect = 4.326e-14
Identity = 33/77 (42.86%), Postives = 44/77 (57.14%), Query Frame = 2

Query:  431 GNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            G KL L       F +WL   ++CP+ Y W EL+  FWPR++K+G C S  SCS P GM CK       T L+W+C+
Sbjct:  131 GQKLKLGKRARRKFLQWLWAHTACPVVYSWKELNVRFWPRYIKEGSCYSARSCSVPEGMVCKPVKFSNKTFLRWHCQ 207

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Sea Lamprey
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 64.3142 bits (155), Expect = 2.023e-12
Identity = 30/77 (38.96%), Postives = 43/77 (55.84%), Query Frame = 2

Query:  431 GNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            G K+ +         +WL   + CP+ Y W +L   FWPR+VK+G C +  SCS+P GM CK       TLL+W+C+
Sbjct:  120 GQKIKIGKRARRKILQWLWSYTFCPVLYTWKDLGERFWPRFVKEGSCYNGRSCSFPEGMACKPFKSASKTLLRWHCQ 196

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009391.1 (pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-1 gene:ENSPMAG00000008500.1 transcript:ENSPMAT00000009391.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.8474 bits (146), Expect = 2.322e-11
Identity = 27/95 (28.42%), Postives = 43/95 (45.26%), Query Frame = 2

Query:  380 RIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGIC--VSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            ++    +  N+T     G  +  +        RWL Q++ C +   W +L   FWPRWV++  C       CSWP GM+C       + +L W+C
Sbjct:   77 KLHAAARALNFTVLTDSGAAVAATEATAAFMTRWLLQKAECGVASSWHDLGSVFWPRWVRRSHCEESGGGGCSWPAGMSCAPAQSTHIKILAWHC 171

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011420.1 (pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gene:ENSPMAG00000010393.1 transcript:ENSPMAT00000011420.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.4622 bits (145), Expect = 4.648e-11
Identity = 24/55 (43.64%), Postives = 35/55 (63.64%), Query Frame = 2

Query:  494 SSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            + CP+ Y W +L   FWPR+V++G C S  SCS P GM+CK++      +L+W C
Sbjct:  155 TQCPVAYAWKDLGGRFWPRYVREGSCQSGRSCSIPAGMSCKAQRSTSKAILRWYC 209

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Nematostella
Match: EDO36952 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH36])

HSP 1 Score: 52.373 bits (124), Expect = 8.091e-9
Identity = 27/76 (35.53%), Postives = 37/76 (48.68%), Query Frame = 2

Query:  431 GNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
            G    L P      + WL + SSCP+   W +     WPR+   G C    +CS+P GM CK    K++ LL+W C
Sbjct:   15 GEGRNLGPKASRKLQLWLWELSSCPVYQKWKDQGQLIWPRYRNIGRCSRKSTCSYPGGMKCKRSKTKRVALLRWFC 90

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Nematostella
Match: EDO36981 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH37])

HSP 1 Score: 51.6026 bits (122), Expect = 1.294e-8
Identity = 24/63 (38.10%), Postives = 36/63 (57.14%), Query Frame = 2

Query:  479 WLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEID 667
            WL Q  +CP+ Y W ++ P FWPR+VK+  C S   CS  P   C+  + +   +L+W+C  D
Sbjct:   12 WLLQRENCPVVYSWRDMGPHFWPRFVKRATCKS-KQCSIDPSTQCEPSNSRYFNILRWHCMDD 73

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Medaka
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 64.3142 bits (155), Expect = 1.003e-11
Identity = 30/63 (47.62%), Postives = 38/63 (60.32%), Query Frame = 2

Query:  470 FRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNC 658
             ++WL   S CP+ Y WT+L   FWPR+V+ G C+S  SCS P GM CK      LT L+W C
Sbjct:  137 LQQWLWAYSFCPVLYSWTDLGNRFWPRFVRVGSCLSKRSCSVPEGMVCKPASSTHLTTLRWRC 199

[Close]

BLAST of noggin-like protein 2 vs. Ensembl Medaka
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 63.1586 bits (152), Expect = 2.278e-11
Identity = 27/64 (42.19%), Postives = 38/64 (59.38%), Query Frame = 2

Query:  470 FRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCE 661
            F +WL   + CP+ Y W +L   FWPR++K+G C S  SCS+P GM+CK         L+W C+
Sbjct:  127 FLQWLWTYTHCPVVYTWKDLGVRFWPRYIKEGKCFSERSCSFPEGMSCKPAKSINKIFLRWYCQ 190

[Close]

BLAST of noggin-like protein 2 vs. Planmine SMEST
Match: SMESG000034689.1 (SMESG000034689.1)

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 279/280 (99.64%), Postives = 280/280 (100.00%), Query Frame = 2

Query:   68 MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQ+DVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE
Sbjct:    1 MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQVDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 280

[Close]

BLAST of noggin-like protein 2 vs. Planmine SMEST
Match: SMESG000034679.1 (SMESG000034679.1)

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 279/280 (99.64%), Postives = 280/280 (100.00%), Query Frame = 2

Query:   68 MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQ+DVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE
Sbjct:    1 MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQVDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 280

[Close]

BLAST of noggin-like protein 2 vs. Planmine SMEST
Match: SMESG000007405.1 (SMESG000007405.1)

HSP 1 Score: 254.603 bits (649), Expect = 5.416e-84
Identity = 121/260 (46.54%), Postives = 178/260 (68.46%), Query Frame = 2

Query:  134 LTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRG--VRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            ++ +++ KPI     ++   IV VR ++       F PN++ +I K L++ILD + LFD+W++   P +IYIP NGT +ID R++ L+KMKN+ FK+++G K+ L+ +++DS + WLE+ESSC M+YIW EL+PSFWPRW+KKG+CVS+ SCSWPPGM+CK+K  K L LLQ+ CE DP K KY AD   M+ ++  R KRQ K++ R+    + R    R+V+T + KE++ K  I  LRE+++ FYCKW K  Y V E
Sbjct:    1 MSTKTTRKPITINLTTNEQNIVGVRFNFNEIIVTNFIPNLSPSIDKKLKKILDSDHLFDNWLALTKPAEIYIPLNGTNKIDSRLRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVSLTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVFQGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNE 260

[Close]

BLAST of noggin-like protein 2 vs. Planmine SMEST
Match: SMESG000034704.1 (SMESG000034704.1)

HSP 1 Score: 253.062 bits (645), Expect = 4.518e-83
Identity = 123/277 (44.40%), Postives = 185/277 (66.79%), Query Frame = 2

Query:   83 DLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRG--VRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            +L+ ++ LF    +   ++ +++ KPI     ++   IV VR ++       F PN++ +I K L++ILD + LF +W++   P +IYIP NGT +ID R++ L+KMKN+ FK+++G K+ L+ +++DS + WLE+ESSC M+YIW EL+PSFWPRW+KKG+CVS+ SCSWPPGM+CK+K  K L LLQ+ CE DP K KY AD   M+ ++  R KRQ K++ R+    + R    R+V+T + KE++ K  I  LRE+++ FYCKW K  Y V E
Sbjct:    8 NLTFVVILFI---IKIGMSTKTTRKPITINLTTNEQNIVGVRFNFNEIIVTNFIPNLSPSIDKKLKKILDSDHLFGNWLALTKPAEIYIPLNGTNKIDSRLRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVSLTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVFQGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNE 281

[Close]

BLAST of noggin-like protein 2 vs. Planmine SMEST
Match: SMESG000007613.1 (SMESG000007613.1)

HSP 1 Score: 200.675 bits (509), Expect = 8.414e-63
Identity = 105/248 (42.34%), Postives = 155/248 (62.50%), Query Frame = 2

Query:  170 ETESSNVIIVPVRNSYQLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTKQIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKR--RGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIE 907
            E +S N       + Y++P    F PN+T N  + L+QI+    L D+WIS   P Q+Y   N  + +  R++FLVKMKN T  D+ G K+ +S  ++ S ++WL +ES C ++Y W EL+ ++WPRWVKKG+CV++ SCSWPPGMNC     +KL+LLQW C  D  K KYK D + ++  ++IR KRQN  +  +  S KR  R  RK+  S+S  +K + R+ KL  + + FYCKW++V Y+VI+
Sbjct:   21 EGKSKNKDFRKFSHYYEVPSYLHF-PNITHNTRRILQQIIHNGILVDNWISITKPHQLYQSSNEPENVSKRMRFLVKMKNITLIDKNGFKINISKTILTSIQQWLIEESKCQVEYHWQELNETYWPRWVKKGLCVNIKSCSWPPGMNCSPNSYRKLSLLQWICAEDKRKEKYKDDKLLIKIARKIRRKRQNIYNNSKFKSKKRWLRLPRKLEESQSNAIKIRLRLFKLSLYTEGFYCKWREVHYRVIQ 267

The following BLAST results are available for this feature:

BLAST of noggin-like protein 2 vs. Ensembl Human
BLAST of noggin-like protein 2 vs. Ensembl Celegans
BLAST of noggin-like protein 2 vs. Ensembl Fly
BLAST of noggin-like protein 2 vs. Ensembl Zebrafish
BLAST of noggin-like protein 2 vs. Ensembl Xenopus
BLAST of noggin-like protein 2 vs. Ensembl Mouse
BLAST of noggin-like protein 2 vs. UniProt/SwissProt
BLAST of noggin-like protein 2 vs. TrEMBL
BLAST of noggin-like protein 2 vs. Ensembl Cavefish
BLAST of noggin-like protein 2 vs. Ensembl Sea Lamprey
BLAST of noggin-like protein 2 vs. Ensembl Yeast
BLAST of noggin-like protein 2 vs. Ensembl Nematostella
BLAST of noggin-like protein 2 vs. Ensembl Medaka
BLAST of noggin-like protein 2 vs. Planmine SMEST

BLAST of noggin-like protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
NOG	2.312e-12	38.20	noggin [Source:HGNC Symbol;Acc:HGNC:7866]	[more]

BLAST of noggin-like protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nog2	1.568e-11	30.33	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog1	2.218e-11	36.08	noggin 1 [Source:NCBI gene;Acc:30174]	[more]
nog3	3.740e-10	35.63	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	3.740e-10	35.63	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	3.849e-10	35.63	noggin 3 [Source:NCBI gene;Acc:30173]	[more]

BLAST of noggin-like protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nog	1.501e-13	40.24	noggin [Source:NCBI gene;Acc:493191]	[more]
nog4	1.306e-12	40.85	noggin 4 [Source:NCBI gene;Acc:733455]	[more]
acad10	3.039e-11	37.66	acyl-CoA dehydrogenase family member 10 [Source:Xe...	[more]

BLAST of noggin-like protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Nog	1.512e-12	38.20	noggin [Source:MGI Symbol;Acc:MGI:104327]	[more]

BLAST of noggin-like protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O93525\|NOGG_CHICK	4.583e-12	40.00	Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1	[more]
sp\|P49011\|NOGG_XENLA	7.859e-12	39.02	Noggin OS=Xenopus laevis OX=8355 GN=nog PE=1 SV=1	[more]
sp\|Q9YHT8\|NOGG_TAKRU	8.211e-12	46.03	Noggin OS=Takifugu rubripes OX=31033 GN=nog PE=3 S...	[more]
sp\|P97466\|NOGG_MOUSE	1.058e-11	38.20	Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1	[more]
sp\|Q13253\|NOGG_HUMAN	1.110e-11	38.20	Noggin OS=Homo sapiens OX=9606 GN=NOG PE=1 SV=1	[more]

BLAST of noggin-like protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C1JAC2	0.000e+0	99.64	Noggin-like protein 2 OS=Schmidtea mediterranea OX...	[more]
C1JAC5	2.720e-80	44.77	Noggin-like protein 5 OS=Schmidtea mediterranea OX...	[more]
C1JAC3	1.595e-58	41.94	Noggin-like protein 3 OS=Schmidtea mediterranea OX...	[more]
T1D134	1.821e-38	33.63	Nlg1 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1	[more]
A8SLH5	8.077e-30	35.65	Noggin-like protein 1 OS=Schmidtea mediterranea OX...	[more]

BLAST of noggin-like protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog3	4.199e-11	48.33	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
ENSAMXT00000051007.1	5.495e-9	37.04	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of noggin-like protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
nog2	4.326e-14	42.86	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog3	2.023e-12	38.96	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
ENSPMAT00000009391.1	2.322e-11	28.42	pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-...	[more]
ENSPMAT00000011420.1	4.648e-11	43.64	pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gen...	[more]

BLAST of noggin-like protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36952	8.091e-9	35.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36981	1.294e-8	38.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of noggin-like protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog1	1.003e-11	47.62	noggin 1 [Source:NCBI gene;Acc:30174]	[more]
nog2	2.278e-11	42.19	noggin 2 [Source:NCBI gene;Acc:30185]	[more]

BLAST of noggin-like protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000034689.1	0.000e+0	99.64	SMESG000034689.1	[more]
SMESG000034679.1	0.000e+0	99.64	SMESG000034679.1	[more]
SMESG000007405.1	5.416e-84	46.54	SMESG000007405.1	[more]
SMESG000034704.1	4.518e-83	44.40	SMESG000034704.1	[more]
SMESG000007613.1	8.414e-63	42.34	SMESG000007613.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30002427
GenBank	ACO06227.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30002427 ID=SMED30002427|Name=noggin-like protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=949bp
AATCAAATAATTAATTTAAAAAAATGGATTAAAATAATGATTATTTTTCA
TTTAACAATTTAAGTAAATGTATTACAGAAAAGATTTATCACAATTAATT
TGTCTATTTTGTTTCGCCGAACTAAATTGTCAACTTACAAACGAATCAAG
CGTGAAACCAATAGAAAATGAAACCGAAAGTTCTAATGTTATAATTGTTC
CAGTTCGTAATAGTTATCAGTTGCCTCGAACCAACAAATTTTATCCAAAC
GTAACACAAAATATTGCAAAGACTTTACGTCAAATCCTTGACCAAGAACA
ACTGTTTGATGATTGGATTTCTAGCAGAATTCCAAAACAAATTTACATTC
CATTCAATGGAACAAAACAAATTGATGTTCGTATTCAATTTTTAGTCAAA
ATGAAAAACTATACATTCAAAGATAGAAAAGGAAATAAATTATATCTTTC
TCCTAATGTTGTCGATTCATTTCGACGATGGTTAGAACAAGAATCCAGTT
GTCCTATGGATTATATTTGGACAGAATTGGATCCAAGCTTTTGGCCAAGA
TGGGTAAAGAAAGGAATTTGTGTGTCAGTCGTCAGTTGTTCCTGGCCTCC
TGGAATGAATTGTAAATCAAAACATAAGAAGAAATTGACTTTACTTCAAT
GGAACTGTGAAATAGATCCTGACAAATCGAAATACAAAGCTGACACTATG
CAAATGCGAAGCATAAAAAGAATTCGAGTTAAAAGACAAAACAAATTACA
TAAACGCAGAAATACTTCAAGCAAACGTCGAGGAGTTAGGAAAGTAATGA
CTAGTAAAAGTAAAGAGCTGAAAAATAAAAAACGGATATTAAAATTGAGA
GAGCACATAGATGATTTCTATTGTAAATGGAAAAAAGTTACTTATCAAGT
TATTGAATTCTGTTCCTGTTATTGTTAATAAAAATTTTTTTGTATTGTG

protein sequence of SMED30002427-orf-1

>SMED30002427-orf-1 ID=SMED30002427-orf-1|Name=SMED30002427-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=287bp
MYYRKDLSQLICLFCFAELNCQLTNESSVKPIENETESSNVIIVPVRNSY
QLPRTNKFYPNVTQNIAKTLRQILDQEQLFDDWISSRIPKQIYIPFNGTK
QIDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYI
WTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEID
PDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKE
LKNKKRILKLREHIDDFYCKWKKVTYQVIEFCSCYC*

Aliases

The feature 'noggin-like protein 2' has the following synonyms


Synonym
nlg-2

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002075	pigment cell
PLANA:0003104	enteric muscle cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR008717	Noggin
IPR029034	Cystine-knot_cytokine

Vocabulary: **biological process**
Term	Definition
GO:0030514	negative regulation of BMP signaling pathway
GO:0045596	negative regulation of cell differentiation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR029034	Cystine-knot cytokine	GENE3D	G3DSA:2.10.90.10		coord: 60..200 e-value: 5.4E-26 score: 93.9
IPR029034	Cystine-knot cytokine	SUPERFAMILY	SSF57501	Cystine-knot cytokines	coord: 63..286
None	No IPR available	PFAM	PF05806	Noggin	coord: 111..286 e-value: 3.0E-17 score: 63.3
None	No IPR available	GENE3D	G3DSA:1.10.287.520		coord: 94..144 e-value: 5.4E-26 score: 93.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 226..243
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 226..249
None	No IPR available	PANTHER	PTHR10494:SF6	NOGGIN	coord: 98..286
IPR008717	Noggin	PANTHER	PTHR10494	BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN	coord: 98..286

Main menu

noggin-like protein 2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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