cAMP-dependent protein kinase regulatory subunit

Overview
NamecAMP-dependent protein kinase regulatory subunit
Smed IDSMED30002366
Length (bp)2286
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of cAMP-dependent protein kinase regulatory subunit (SMED30002366) t-SNE clustered cells

Violin plots show distribution of expression levels for cAMP-dependent protein kinase regulatory subunit (SMED30002366) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of cAMP-dependent protein kinase regulatory subunit (SMED30002366) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for cAMP-dependent protein kinase regulatory subunit (SMED30002366) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30002366

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30002366SMESG000052390.1 SmedASXL_015414SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
protonephridiaSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002366SMESG000052390.1 Contig39763uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002366SMESG000052390.1 Contig39763newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
epidermisSMED30002366SMESG000052390.1 dd_Smed_v4_7586_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 53.1434 bits (126), Expect = 2.115e-6
Identity = 36/129 (27.91%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E GSTFFI+  GKV +  +TE   +P+                                  I  ++ G  FGE ALISDDVR+A II++      LV+++  +N+++
Sbjct:  296 TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQ---------------------------------LIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 391
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 52.7582 bits (125), Expect = 2.338e-6
Identity = 36/129 (27.91%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E GSTFFI+  GKV +  +TE   +P+                                  I  ++ G  FGE ALISDDVR+A II++      LV+++  +N+++
Sbjct:  296 TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQ---------------------------------LIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 391
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 52.7582 bits (125), Expect = 2.338e-6
Identity = 36/129 (27.91%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E GSTFFI+  GKV +  +TE   +P+                                  I  ++ G  FGE ALISDDVR+A II++      LV+++  +N+++
Sbjct:  296 TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQ---------------------------------LIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 391
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9392])

HSP 1 Score: 50.8322 bits (120), Expect = 6.429e-6
Identity = 49/228 (21.49%), Postives = 97/228 (42.54%), Query Frame = 3 
Query:  333 RTDLESNTICQWLIQNFRIFSKIQPETVDDIVQN--SRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVE-GQAKVVM 1007
            +TD + N + Q   ++  +F  + PE +  ++     +L++  E+  +I Q + G  F++I  G   IY+  + V                                   G  +G  +    FGE+AL+ +  R ATI + +      L++  + R + KN   + +M+ +F+ + P   +     + +V   +  +++    +II QGD  +   FIVE G+ K+ M
Sbjct:  137 KTDDQRNRL-QEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH--VIDQGDDGDNFYVIDRGTFDIYVKCDGV-----------------------------------GRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSF-FIVESGEVKITM 325
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9392])

HSP 1 Score: 50.8322 bits (120), Expect = 6.429e-6
Identity = 49/228 (21.49%), Postives = 97/228 (42.54%), Query Frame = 3 
Query:  333 RTDLESNTICQWLIQNFRIFSKIQPETVDDIVQN--SRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVE-GQAKVVM 1007
            +TD + N + Q   ++  +F  + PE +  ++     +L++  E+  +I Q + G  F++I  G   IY+  + V                                   G  +G  +    FGE+AL+ +  R ATI + +      L++  + R + KN   + +M+ +F+ + P   +     + +V   +  +++    +II QGD  +   FIVE G+ K+ M
Sbjct:  137 KTDDQRNRL-QEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH--VIDQGDDGDNFYVIDRGTFDIYVKCDGV-----------------------------------GRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSF-FIVESGEVKITM 325
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: kin-2 (cAMP-dependent protein kinase regulatory subunit [Source:UniProtKB/Swiss-Prot;Acc:P30625])

HSP 1 Score: 57.3806 bits (137), Expect = 1.782e-8
Identity = 45/198 (22.73%), Postives = 79/198 (39.90%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDHL 1061
            +I Q E G  F++I  G V +Y+N E                                       ++  I  G  FGE+ALI    R AT+I+ T  +   +++  Y R L  +   + +M+  F++   +  +     +  VA +L R  F     +++QG   +    I+EG+A V   + + S   P  ++  HL
Sbjct:  117 IIEQGEEGDNFYVIDKGTVDVYVNHE---------------------------------------YVLTINEGGSFGELALIYGTPRAATVIAKTDVKLWAIDRLTYRRILMGSVTKKRKMYDEFLSKVQILADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANV---LQKRSDDAP-FDVVGHL 271
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: kin-2 (cAMP-dependent protein kinase regulatory subunit [Source:UniProtKB/Swiss-Prot;Acc:P30625])

HSP 1 Score: 56.9954 bits (136), Expect = 2.410e-8
Identity = 45/198 (22.73%), Postives = 79/198 (39.90%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDHL 1061
            +I Q E G  F++I  G V +Y+N E                                       ++  I  G  FGE+ALI    R AT+I+ T  +   +++  Y R L  +   + +M+  F++   +  +     +  VA +L R  F     +++QG   +    I+EG+A V   + + S   P  ++  HL
Sbjct:  149 IIEQGEEGDNFYVIDKGTVDVYVNHE---------------------------------------YVLTINEGGSFGELALIYGTPRAATVIAKTDVKLWAIDRLTYRRILMGSVTKKRKMYDEFLSKVQILADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANV---LQKRSDDAP-FDVVGHL 303
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: kin-2 (cAMP-dependent protein kinase regulatory subunit [Source:UniProtKB/Swiss-Prot;Acc:P30625])

HSP 1 Score: 56.6102 bits (135), Expect = 3.323e-8
Identity = 45/198 (22.73%), Postives = 79/198 (39.90%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDHL 1061
            +I Q E G  F++I  G V +Y+N E                                       ++  I  G  FGE+ALI    R AT+I+ T  +   +++  Y R L  +   + +M+  F++   +  +     +  VA +L R  F     +++QG   +    I+EG+A V   + + S   P  ++  HL
Sbjct:  159 IIEQGEEGDNFYVIDKGTVDVYVNHE---------------------------------------YVLTINEGGSFGELALIYGTPRAATVIAKTDVKLWAIDRLTYRRILMGSVTKKRKMYDEFLSKVQILADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANV---LQKRSDDAP-FDVVGHL 313
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: Pka-R2 (gene:FBgn0022382 transcript:FBtr0112902)

HSP 1 Score: 58.151 bits (139), Expect = 1.614e-8
Identity = 48/213 (22.54%), Postives = 91/213 (42.72%), Query Frame = 3 
Query:  372 IQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD 1010
            ++N  +F  ++ E ++ ++      +      +IRQ + G  F++I +G   +YIN + +                                N Y N  G+      FGE+AL+ +  R AT+ ++T      +++  + R L K+   + +M+   +N+ P+        +  +A +L  + +     IIKQGD  +G+ FI EG   V MD
Sbjct:  119 VKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHI--------------------------------NTY-NHTGL------FGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMD 292
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: Pka-R2 (gene:FBgn0022382 transcript:FBtr0088437)

HSP 1 Score: 57.7658 bits (138), Expect = 1.932e-8
Identity = 48/213 (22.54%), Postives = 91/213 (42.72%), Query Frame = 3 
Query:  372 IQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD 1010
            ++N  +F  ++ E ++ ++      +      +IRQ + G  F++I +G   +YIN + +                                N Y N  G+      FGE+AL+ +  R AT+ ++T      +++  + R L K+   + +M+   +N+ P+        +  +A +L  + +     IIKQGD  +G+ FI EG   V MD
Sbjct:  119 VKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHI--------------------------------NTY-NHTGL------FGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMD 292
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: Pka-R2 (gene:FBgn0022382 transcript:FBtr0088438)

HSP 1 Score: 57.7658 bits (138), Expect = 1.932e-8
Identity = 48/213 (22.54%), Postives = 91/213 (42.72%), Query Frame = 3 
Query:  372 IQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD 1010
            ++N  +F  ++ E ++ ++      +      +IRQ + G  F++I +G   +YIN + +                                N Y N  G+      FGE+AL+ +  R AT+ ++T      +++  + R L K+   + +M+   +N+ P+        +  +A +L  + +     IIKQGD  +G+ FI EG   V MD
Sbjct:  119 VKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHI--------------------------------NTY-NHTGL------FGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMD 292
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: Pka-R2 (gene:FBgn0022382 transcript:FBtr0112901)

HSP 1 Score: 57.3806 bits (137), Expect = 2.523e-8
Identity = 48/213 (22.54%), Postives = 91/213 (42.72%), Query Frame = 3 
Query:  372 IQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD 1010
            ++N  +F  ++ E ++ ++      +      +IRQ + G  F++I +G   +YIN + +                                N Y N  G+      FGE+AL+ +  R AT+ ++T      +++  + R L K+   + +M+   +N+ P+        +  +A +L  + +     IIKQGD  +G+ FI EG   V MD
Sbjct:  119 VKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHI--------------------------------NTY-NHTGL------FGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMD 292
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: Pka-R1 (gene:FBgn0259243 transcript:FBtr0302638)

HSP 1 Score: 50.447 bits (119), Expect = 3.669e-6
Identity = 47/191 (24.61%), Postives = 78/191 (40.84%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPD 1040
            +I+Q + G  F++I  G+V +++N+ELVT                                        I  G  FGE+ALI    R AT+ + T  +   +++  Y R L  +   + +M+  F++   +  +     +  VA SL    F     I+KQG   +    I+EG A V   + Q S+Q  D
Sbjct:  104 IIQQGDEGDNFYVIDVGEVDVFVNSELVT---------------------------------------TISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVV---LQQRSEQGED 252
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Match: prkar2aa (protein kinase, cAMP-dependent, regulatory, type II, alpha A [Source:ZFIN;Acc:ZDB-GENE-030131-1007])

HSP 1 Score: 52.7582 bits (125), Expect = 9.819e-7
Identity = 32/127 (25.20%), Postives = 60/127 (47.24%), Query Frame = 3 
Query:  627 YPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVM 1007
            Y  V  ++  G  +G       FGE+AL+ +  R ATII+  +     L++  + R + KN   + +M+  F+ + P+  +     + ++   L  + F     II QGDK +    +  G+ K++M
Sbjct:  181 YDIVVQKDGVGCCVGQYNNKGSFGELALMYNTPRAATIIAKDEGALWGLDRATFRRLIVKNNAKKRRMYECFIESIPLLKSLELSERMKIVDVLGVKTFQDGERIIMQGDKADCFYIVESGEVKIMM 307
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Match: ptafr (platelet activating factor receptor [Source:Xenbase;Acc:XB-GENE-968925])

HSP 1 Score: 55.4546 bits (132), Expect = 2.974e-7
Identity = 37/117 (31.62%), Postives = 57/117 (48.72%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIIS-DTQSQFLVLEKTVYNRSLRKNQE 815
            +IR+ E GSTFFII  GKV +  +TE   EP+                                 +I  +E G  FGE ALISDDVR+A I++   + + LV+++  +N+++   +E
Sbjct:  339 IIREGEEGSTFFIISKGKVKVTQSTEGYKEPQ---------------------------------YIKFLEKGDYFGEKALISDDVRSANILAYGDRVECLVMDRETFNKTVGTYEE 422
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Match: fgf1 (fibroblast growth factor 1 [Source:Xenbase;Acc:XB-GENE-485966])

HSP 1 Score: 50.0618 bits (118), Expect = 6.994e-6
Identity = 54/228 (23.68%), Postives = 100/228 (43.86%), Query Frame = 3 
Query:  342 LESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIR---QNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPV--FYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVE-GQAKVVM 1007
            L  N +C   + +      ++P+T +   Q  RL E  ++ LL +   Q +L      +           E+  +P+E  I    +       E+   Y    +R+     +G  +    FGE+AL+ +  R ATI++ ++     L++  + R + KN   + + +  F+ + PV  F   + R K    ++ R  ++     II QGDK +   FIVE G+ K++M
Sbjct:    2 LYYNIVCA--LAHLYTLGVVRPKTDE---QRCRLQEACKDILLFKNLDQEQLSQVLDAMF----------EMRVKPQEHVIDQGDDGDNFYVVER-GQYDIFVERDGQSRCVGRYDNHGSFGELALMYNTPRAATIVATSEGALWGLDRVTFRRIILKNNAKKRKTYEIFIESVPVLKFLELSERMKIVDVIAAR--VYKDGDRIIAQGDKADCF-FIVESGEVKIMM 210
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Cnbd2 (cyclic nucleotide binding domain containing 2 [Source:MGI Symbol;Acc:MGI:1918123])

HSP 1 Score: 55.4546 bits (132), Expect = 1.609e-7
Identity = 66/275 (24.00%), Postives = 121/275 (44.00%), Query Frame = 3 
Query:  315 KKPLLDRTDLESNTICQWL--IQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKT--VYNRSLRKNQEAEFQMFINFVNNSPVFYNWA-PRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDI------TQHSQQYPDLNITDHLVQTKSLSTLQNGMLI 1106
            KKP   RT  E   +C  L  +  +R +++     +  +++  R        +++++ ++G++F+ I       Y+ T  +TE E+   GS++          LD +P +  R            G  FGEM L+S  VR+AT++   +++FLV+++   V N+ L    + E Q   NF  N  +F +W+  +  K VA+  R + F +   + K       I FI +G  +++  +        +   +  L + DH    K L    NG L 
Sbjct:   67 KKPSW-RTHQEIQDLCNILQALDCYRSYTESLQLLLAKVIRFERF---GRRRVIVKKGQMGNSFYFI-------YLGTVAITEDED---GSSAF---------LDPHPTLLHR------------GGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANK-LGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALG-RIERFSYGQMVSKDFMNSAFITFICQGNCEILRLVALGDCSAYYKWVWQQLELLDH----KPLRIHDNGFLC 300
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Cnbd2 (cyclic nucleotide binding domain containing 2 [Source:MGI Symbol;Acc:MGI:1918123])

HSP 1 Score: 53.5286 bits (127), Expect = 8.903e-7
Identity = 48/183 (26.23%), Postives = 89/183 (48.63%), Query Frame = 3 
Query:  465 LLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKT--VYNRSLRKNQEAEFQMFINFVNNSPVFYNWA-PRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVV 1004
            +++++ ++G++F+ I       Y+ T  +TE E+   GS++          LD +P +  R            G  FGEM L+S  VR+AT++   +++FLV+++   V N+ L    + E Q   NF  N  +F +W+  +  K VA+  R + F +   + K       I FI +G  +++
Sbjct:  232 VIVKKGQMGNSFYFI-------YLGTVAITEDED---GSSAF---------LDPHPTLLHR------------GGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANK-LGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALG-RIERFSYGQMVSKDFMNSAFITFICQGNCEIL 381
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Cnbd2 (cyclic nucleotide binding domain containing 2 [Source:MGI Symbol;Acc:MGI:1918123])

HSP 1 Score: 53.5286 bits (127), Expect = 9.067e-7
Identity = 46/182 (25.27%), Postives = 87/182 (47.80%), Query Frame = 3 
Query:  465 LLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVY-NRSLRKNQEAEFQMFINFVNNSPVFYNWA-PRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVV 1004
            +++++ ++G++F+ I       Y+ T  +TE E+   GS++          LD +P +  R            G  FGEM L+S  VR+AT++   +++FLV+++  +    L    + E Q   NF  N  +F +W+  +  K VA+  R + F +   + K       I FI +G  +++
Sbjct:  103 VIVKKGQMGNSFYFI-------YLGTVAITEDED---GSSAF---------LDPHPTLLHR------------GGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALG-RIERFSYGQMVSKDFMNSAFITFICQGNCEIL 252
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 52.7582 bits (125), Expect = 1.637e-6
Identity = 36/129 (27.91%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E GSTFFI+  GKV +  +TE   +P+                                  I  ++ G  FGE ALISDDVR+A II++      LV+++  +N+++
Sbjct:  296 TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQ---------------------------------LIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 391
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 52.7582 bits (125), Expect = 1.904e-6
Identity = 36/129 (27.91%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E GSTFFI+  GKV +  +TE   +P+                                  I  ++ G  FGE ALISDDVR+A II++      LV+++  +N+++
Sbjct:  296 TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQ---------------------------------LIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 391
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|Q86ZN7|KAPR_HYPAT (cAMP-dependent protein kinase regulatory subunit OS=Hypocrea atroviridis OX=63577 GN=pkar1 PE=3 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 2.193e-9
Identity = 45/179 (25.14%), Postives = 77/179 (43.02%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFL-VLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKV 1001
            +I Q + G  F+++  G   +Y+N     EP                             +  GN +G I+ G  FGE+AL+ +  R ATIIS   S  L  L++  + R L ++  A  +M+ NF+   P+  +  P  + +++ +L  Q F     II +GD  +    +  G+A  
Sbjct:  232 VISQGDAGDYFYVVERGSFDVYVNDCGFIEP---------------------------GPDGLGNKVGTIQAGGSFGELALMYNAPRAATIISAEGSCTLWALDRVTFRRILMESTFARRRMYENFLEEVPILSSLTPYERSKISDALETQKFAPGDVIIHEGDPGHSFYLLESGEAAA 383
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|Q01386|KAPR_NEUCR (cAMP-dependent protein kinase regulatory subunit OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=mcb PE=3 SV=1)

HSP 1 Score: 63.929 bits (154), Expect = 2.393e-9
Identity = 40/179 (22.35%), Postives = 78/179 (43.58%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIIS-DTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKV 1001
            +I Q + G  F+++  G+  +Y+N+    +P                             +  G  +G I  G  FGE+AL+ +  R AT++S + Q     L++  + R L ++  +  +M+ +F+   P+     P  + ++A +L  Q +P   EII +GD  +    +  G+A  
Sbjct:  157 VITQGDAGDYFYVVEKGRFEVYVNSTGALQP---------------------------GPDGMGQKVGEIAEGGSFGELALMYNAPRAATVVSAEPQCTLWALDRVTFRRILMESTFSRRRMYESFLEEVPILKTLTPYERSKIADALESQKYPAGHEIILEGDPGHSFFLLEAGEAAA 308
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|Q9C1C2|KAPR_COLOR (cAMP-dependent protein kinase regulatory subunit OS=Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) OX=1213857 GN=PKAR PE=3 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 3.150e-9
Identity = 53/242 (21.90%), Postives = 107/242 (44.21%), Query Frame = 3 
Query:  321 PLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLE---CDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIIS-DTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQY 1034
            P+ D+T+ + + +   +  NF +FS +  E    I+    L+E     ++  +I Q + G  F+++  G   +Y+N +   +P    +G           EK                +G I+ G  FGE+AL+ +  R AT+IS +       L++  + R L ++  +  +M+ +F+   P+     P  + ++A +L  Q +     IIK+GD  +    +  G+A   +   + S ++
Sbjct:  111 PVHDKTNEQLSRLKTAIAGNF-LFSHLDDEQSAQIL--GALIEKPIPAKDIKVISQGDAGDYFYVVEKGSFDVYVNEKGTLQPGPEGMG-----------EK----------------VGTIQAGGSFGELALMYNAPRAATVISAEPGCTLWALDRLTFRRILMESTFSRRRMYEDFLREVPLLQTLTPYERSKIADALETQKYTPGATIIKEGDPGHSFYLLESGEADAYLGDGKESVKH 322
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|O14448|KAPR_MAGO7 (cAMP-dependent protein kinase regulatory subunit OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=SUM1 PE=1 SV=1)

HSP 1 Score: 62.003 bits (149), Expect = 8.590e-9
Identity = 39/164 (23.78%), Postives = 74/164 (45.12%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFL-VLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGD 956
            +I Q + G  F+++  GK S+++N+  V +                                 G+ +G IE G  FGE+AL+ +  R AT++S   +  L  L++  + R L ++  +  +M+ NF+   P+        + ++A +L  Q +P    +IK+GD
Sbjct:  158 VIVQGDAGDYFYVVEKGKFSVHVNSSGVMQ---------------------------AGTQGLGDHVGTIEAGGSFGELALMYNAPRAATVMSAEPNCVLWALDRVTFRRILMESTFSRRRMYENFLEEVPILSTLTAYERSKIADALETQKYPPGTVVIKEGD 294
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|O59922|KAPR_EMENI (cAMP-dependent protein kinase regulatory subunit OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=pkaR PE=3 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 2.777e-8
Identity = 44/182 (24.18%), Postives = 76/182 (41.76%), Query Frame = 3 
Query:  468 LIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIIS-DTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD 1010
            +I Q + G  F+I+  G   +YIN     +P                             +  G  I  I  G  FGE+AL+ +  R ATI+S + +S    L++  + R L  +     +M+  F+   P+  +  P  + ++A +L    FP    IIK+GD  +    +  G+A+  M+
Sbjct:  188 VISQGDAGDYFYIVEEGHFDVYINPSGSVQPGP---------------------------DGAGTKISTIGPGGSFGELALMYNAPRAATIVSTEPKSTLWALDRITFRRILMDSAFQRRRMYEAFLEEVPLLSSLKPYERAKIADALDTIKFPAGEYIIKEGDPGDAFYLLESGEAEAFME 342
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A267DMG6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig022080g1 PE=4 SV=1)

HSP 1 Score: 313.923 bits (803), Expect = 8.348e-92
Identity = 203/587 (34.58%), Postives = 311/587 (52.98%), Query Frame = 3 
Query:  285 MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARI--GSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDL---------------------NITDHLVQTKSLSTLQNGMLIQXXXXXXXXXXXXXXXX----GPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQT-TAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESEKLEFXXXXXXXXXXXD---FI-TRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSK---------------------------DGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWL-NSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKK 1859
            M    +++ + KP + R D E N +  W +    +  KI+P+   DI++N    E   + ++IRQ + G  F+I + GKVS+YINTE V + P EA++    +S+  +  KKE         DR KYG +I     G GFGE+ALI+ D VRNA+II+D  ++ +V+ + +YNRSL+  QEAEF+  I+FVN  PVF NW  RYK+Q AMSLR+++F FE+ I KQGD +NG+ FI+ GQAK+V+DI QH  QYP L                     N  D   Q++    L +  + +      + +  +  +     GPGE+IGDIEH   L T  +++I  + TEV+ L  +N+ERL+ +K+NQ  T E+L + AE KL+S+  R   +++PLI  L   +L  +   E  + +  +++    +  D   FI +RGP+ID +GPGTVFYRN++ R++    + K+ E K+  +     +                            D  Y      L++   F D++TS   L  LE  I  W  N D +     V ++ RF K+E   + PGK + ++PKK
Sbjct:    1 MSLEQIVECISKPPVQRHDSELNELVGWFLTKCPL--KIKPDVAKDILRNCEFRESPRDDVIIRQGDQGDCFYICLTGKVSVYINTEAVPDDPTEAQVLVDDSSDAASGEKKE--------LDRTKYGKYIVSFGAGRGFGELALINKDCVRNASIIADETTRLIVVNRALYNRSLKAVQEAEFKERIDFVNKCPVFDNWLARYKRQAAMSLRKEMFNFEMTIAKQGDALNGLYFILSGQAKLVVDIIQHYSQYPQLHLHDSPEDLQQREIMGKLMEQNPADERSQSRRHQQLWDKPIRRRGYAAAEHRQSQRHVEISLIGPGEMIGDIEHGMDLSTYAQSVICVQPTEVFVLDSKNFERLVLNKRNQAQTLEILARKAETKLMSRVTRALDKQVPLIRNLCHRILESHRAEERRRQKADKERDFDVRDSDMSHFIPSRGPLIDPYGPGTVFYRNKMKRERKLAAQ-KAKEAKMGGRKPPAAAAAMFAVDEPGTDDEGADGAAAATDHRRLDDPYEAARRVLDE---FEDFDTSSEHLVDLERRISVWFDNVDQTKRGARVVQMTRFHKEEDRKIHPGKKVYMRPKK 573
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A267FVW0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig022080g2 PE=4 SV=1)

HSP 1 Score: 313.153 bits (801), Expect = 1.874e-91
Identity = 209/587 (35.60%), Postives = 319/587 (54.34%), Query Frame = 3 
Query:  285 MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARI--GSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDH---LVQTKSLSTL--QNGM--------------------LIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQT-TAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESEKLEFXXXXXXXXXXXD---FI-TRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSK---------------------------DGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWL-NSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKK 1859
            M    +++ + KP + R D E N +  W +    +  KI+P+   DI++N    E   + ++IRQ + G  F+I + GKVS+YINTE V + P EA++    +S+  +  KKE         DR KYG +I     G GFGE+ALI+ D VRNA+II+D  ++ +V+ + +YNRSL+  QEAEF+  I+FVN  PVF NW  RYK+Q AMSLR+++F FE+ I KQGD +NG+ FI+ GQAK+V+DI QH  QYP L++ D    L Q + +  L  QN                         + E  +  +H+E+SL+GPGE+IGDIEH   L T  +++I  + TEV+ L  +N+ERL+ +K+NQ  T E+L + AE KL+S+  R   +++PLI  L   ++  +   E  + +  +++    +  D   FI +RGP+ID +GPGTVFYRN++ R++    + K+ E K+  +     +                            D  Y      L++   F D++TS   L  LE  I  W  N D +     V ++ RF K+E   + PGK + ++PKK
Sbjct:    1 MSLEQIVECISKPPVQRHDSELNELVGWFLTKCPL--KIKPDVAKDILRNCEFRESPRDDVIIRQGDQGDCFYICLTGKVSVYINTEAVPDDPTEAQVLVDDSSDAASGEKKE--------LDRTKYGKYIVSFGAGRGFGELALINKDCVRNASIIADETTRLIVVNRALYNRSLKAVQEAEFKERIDFVNKCPVFDNWLARYKRQAAMSLRKEMFNFEMTIAKQGDALNGLYFILSGQAKLVVDIIQHYSQYPQLHLHDSPEDLQQREIMGKLMEQNPADERSQSRRHQQLWEKPIRRRGYAAAEHRQSQRHVEISLIGPGEMIGDIEHGMDLSTYAQSVICVQPTEVFVLDSKNFERLVLNKRNQAQTLEILARKAETKLMSRVTRALDKQVPLIRNLCHRIVESHRAEERRRQKADKERDFDVRDSDMSHFIPSRGPLIDPYGPGTVFYRNKMKRERKLAAQ-KAKEAKMGGRKPPAAAAAMFAVDEPGTDDEGADGAAAATDHRRLDDPYEAARRVLDE---FEDFDTSSEHLVDLERRISVWFDNVDQTKRGARVVQMTRFHKEEDRKIHPGKKVYMRPKK 573
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A1I8IH13 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 313.538 bits (802), Expect = 4.405e-88
Identity = 203/587 (34.58%), Postives = 311/587 (52.98%), Query Frame = 3 
Query:  285 MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARI--GSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDL---------------------NITDHLVQTKSLSTLQNGMLIQXXXXXXXXXXXXXXXX----GPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQT-TAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESEKLEFXXXXXXXXXXXD---FI-TRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSK---------------------------DGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWL-NSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKK 1859
            M    +++ + KP + R D E N +  W +    +  KI+P+   DI++N    E   + ++IRQ + G  F+I + GKVS+YINTE V + P EA++    +S+  +  KKE         DR KYG +I     G GFGE+ALI+ D VRNA+II+D  ++ +V+ + +YNRSL+  QEAEF+  I+FVN  PVF NW  RYK+Q AMSLR+++F FE+ I KQGD +NG+ FI+ GQAK+V+DI QH  QYP L                     N  D   Q++    L +  + +      + +  +  +     GPGE+IGDIEH   L T  +++I  + TEV+ L  +N+ERL+ +K+NQ  T E+L + AE KL+S+  R   +++PLI  L   +L  +   E  + +  +++    +  D   FI +RGP+ID +GPGTVFYRN++ R++    + K+ E K+  +     +                            D  Y      L++   F D++TS   L  LE  I  W  N D +     V ++ RF K+E   + PGK + ++PKK
Sbjct:    1 MSLEQIVECISKPPVQRHDSELNELVGWFLTKCPL--KIKPDVAKDILRNCEFRESPRDDVIIRQGDQGDCFYICLTGKVSVYINTEAVPDDPTEAQVLVDDSSDAASGEKKE--------LDRTKYGKYIVSFGAGRGFGELALINKDCVRNASIIADETTRLIVVNRALYNRSLKAVQEAEFKERIDFVNKCPVFDNWLARYKRQAAMSLRKEMFNFEMTIAKQGDALNGLYFILSGQAKLVVDIIQHYSQYPQLHLHDSPEDLQQREIMGKLMEQNPADERSQSRRHQQLWDKPIRRRGYAAAEHRQSQRHVEISLIGPGEMIGDIEHGMDLSTYAQSVICVQPTEVFVLDSKNFERLVLNKRNQAQTLEILARKAETKLMSRVTRALDKQVPLIRNLCHRILESHRAEERRRQKADKERDFDVRDSDMSHFIPSRGPLIDPYGPGTVFYRNKMKRERKLAAQ-KAKEAKMGGRKPPAAAAAMFAVDEPGTDDEGADGAAAATDHRRLDDPYEAARRVLDE---FEDFDTSSEHLVDLERRISVWFDNVDQTKRGARVVQMTRFHKEEDRKIHPGKKVYMRPKK 573
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A1I8INU3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 311.612 bits (797), Expect = 2.543e-87
Identity = 202/582 (34.71%), Postives = 310/582 (53.26%), Query Frame = 3 
Query:  300 VIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARI--GSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDL---------------------NITDHLVQTKSLSTLQNGMLIQXXXXXXXXXXXXXXXX----GPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQT-TAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESEKLEFXXXXXXXXXXXD---FI-TRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSK---------------------------DGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWL-NSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKK 1859
            +++ + KP + R D E N +  W +    +  KI+P+   DI++N    E   + ++IRQ + G  F+I + GKVS+YINTE V + P EA++    +S+  +  KKE         DR KYG +I     G GFGE+ALI+ D VRNA+II+D  ++ +V+ + +YNRSL+  QEAEF+  I+FVN  PVF NW  RYK+Q AMSLR+++F FE+ I KQGD +NG+ FI+ GQAK+V+DI QH  QYP L                     N  D   Q++    L +  + +      + +  +  +     GPGE+IGDIEH   L T  +++I  + TEV+ L  +N+ERL+ +K+NQ  T E+L + AE KL+S+  R   +++PLI  L   +L  +   E  + +  +++    +  D   FI +RGP+ID +GPGTVFYRN++ R++    + K+ E K+  +     +                            D  Y      L++   F D++TS   L  LE  I  W  N D +     V ++ RF K+E   + PGK + ++PKK
Sbjct:  480 IVECISKPPVQRHDSELNELVGWFLTKCPL--KIKPDVAKDILRNCEFRESPRDDVIIRQGDQGDCFYICLTGKVSVYINTEAVPDDPTEAQVLVDDSSDAASGEKKE--------LDRTKYGKYIVSFGAGRGFGELALINKDCVRNASIIADETTRLIVVNRALYNRSLKAVQEAEFKERIDFVNKCPVFDNWLARYKRQAAMSLRKEMFNFEMTIAKQGDALNGLYFILSGQAKLVVDIIQHYSQYPQLHLHDSPEDLQQREIMGKLMEQNPADERSQSRRHQQLWDKPIRRRGYAAAEHRQSQRHVEISLIGPGEMIGDIEHGMDLSTYAQSVICVQPTEVFVLDSKNFERLVLNKRNQAQTLEILARKAETKLMSRVTRALDKQVPLIRNLCHRILESHRAEERRRQKADKERDFDVRDSDMSHFIPSRGPLIDPYGPGTVFYRNKMKRERKLAAQ-KAKEAKMGGRKPPAAAAAMFAVDEPGTDDEGADGAAAATDHRRLDDPYEAARRVLDE---FEDFDTSSEHLVDLERRISVWFDNVDQTKRGARVVQMTRFHKEEDRKIHPGKKVYMRPKK 1047
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A267GYH0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig027341g1 PE=4 SV=1)

HSP 1 Score: 268.855 bits (686), Expect = 1.669e-74
Identity = 197/630 (31.27%), Postives = 312/630 (49.52%), Query Frame = 3 
Query:  285 MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELV-------------------------TEPEEAR----IGS----ASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITD------------------HLVQTKSLSTLQNGMLIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQT-TAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESEKLEFXXXXX-------XXXXXXDFI-TRGPIIDMFGPGTVFYRNRLLRQKN--QKKRSKSNEPKLKSQ-------------STTDDSKD-----------------------GKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPK-----LRRFIKKETDIVKPGKTILLKPKKL 1862
            M  + ++  + K   +R+D E   +  W +    +   I+P+   DI++N    +C  + ++IRQ E G +F+II++GKVS+YINTE V                          +PE+++    + S    AS   TS       +  K  DR KYGNFI     G  FGE+ALI+ D VRNA+II+D  +  + + + +YNRSLR  QEAE +    FV+   VF +W  +Y++Q AMSLR++ F F+  I++QGD ++G+ FIV GQAKVV++I  H  QYP L + +                  H  QT     +Q+           + +HLELSLVGPGE+IGDIEH   L T  ++++ T+ + V+ L  +NY+RL  +K+N   + ++L + A+ KL+S+  RP    +PLI R +   +    + E+ + E               +    FI +RG +ID +GPGTVFYRNR+ R++   Q  R  ++  ++K++             +  D S                           +N +  QL +   F D +TS  +L  LE+ I++WL S    TK  VP      + RF  ++   + PG+ + L+P++L
Sbjct:    1 MSLSHIVQCISKSASERSDSEVIELVDWFLNMCPL--NIKPDVARDILRNCAFRQCQRDDVIIRQGEQGDSFYIILDGKVSVYINTEAVLDDPDDEATTTGGEEAAQAAVNATAAQPEQSQGPVSVSSLKRKASKGGTSAAIAAATAEKKELDRTKYGNFIVNFGAGKSFGELALINKDCVRNASIIADEPTLLIEVNRDLYNRSLRSVQEAELRERFEFVSRCNVFDSWPSKYRRQAAMSLRKENFGFDATIVRQGDPLDGLQFIVSGQAKVVVNIPMHPGQYPLLGLREFHFGSDEQPPTGSSQDRHHRAQTTPHRRVQH-----------QQRHLELSLVGPGELIGDIEHGMELPTYAQSIVCTQPSVVFVLDAKNYDRLAQNKRNPGRSQDVLVERAKAKLISRAGRPLDWGVPLI-RCLYERIVAARRLEAHRREVAASAAAAPSYAVKSASVSHFIPSRGALIDPYGPGTVFYRNRVKREQRAAQAARLTASTKQIKTKDLQQQGNKKTAELAAPDGSSSKLPLGEEEEEQEEDEQKEEAAEQSSFNNLSNQLRQRKQFEDADTSSERLSNLESRIDNWLRSVDG-TKAGVPARPVTVMNRFRNEDDHKIHPGRRVCLRPRRL 615
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkar2aa (protein kinase, cAMP-dependent, regulatory, type II, alpha A [Source:ZFIN;Acc:ZDB-GENE-030131-1007])

HSP 1 Score: 55.4546 bits (132), Expect = 1.076e-7
Identity = 37/155 (23.87%), Postives = 72/155 (46.45%), Query Frame = 3 
Query:  543 ELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVM 1007
            E++ +P+E  I    +       E+   Y  V  ++  G  +G  +    FGE+AL+ +  R ATII+  +     L++  + R + KN   + +M+  F+ + P+  +     + ++   L  +IF     II QGD  +    +  G+ K++M
Sbjct:  140 EVIVQPQEHVIDQGDDGDNFYVIER-GVYDIVVQKDGVGCCVGQYDNKGSFGELALMYNTPRAATIIAKQEGALWGLDRATFRRLIVKNNAKKRRMYECFIESVPLLKSLEISERMKIVDVLGVKIFHDGERIIMQGDMADCFYIVESGEVKIMM 293
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 50.447 bits (119), Expect = 6.685e-6
Identity = 35/129 (27.13%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E G+TF+II  GKV +  +T+   EP+                                  I  ++ G  FGE ALISDDVR+A II+D    + LV+++  + +++
Sbjct:  303 TKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHEEPQ---------------------------------VINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTV 398
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 50.0618 bits (118), Expect = 8.500e-6
Identity = 35/129 (27.13%), Postives = 61/129 (47.29%), Query Frame = 3 
Query:  435 SRLLEC------DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQS-QFLVLEKTVYNRSL 800
            +++++C      D+   +IR+ E G+TF+II  GKV +  +T+   EP+                                  I  ++ G  FGE ALISDDVR+A II+D    + LV+++  + +++
Sbjct:  303 TKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHEEPQ---------------------------------VINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTV 398
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Match: prkar2aa (protein kinase, cAMP-dependent, regulatory, type II, alpha A [Source:ZFIN;Acc:ZDB-GENE-030131-1007])

HSP 1 Score: 51.2174 bits (121), Expect = 2.514e-7
Identity = 33/132 (25.00%), Postives = 66/132 (50.00%), Query Frame = 3 
Query:  615 KLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVE-GQAKVVM 1007
            K+D  PK          +G  +    FGE+AL+ +  R ATI++ T+     +++  + R + KN   + +M+  F+ + P+  +     + +V  ++  + +    +II QG K +   FIVE G+ +++M
Sbjct:    9 KIDGAPKK---------VGCYDNRGSFGELALMYNTPRAATIVATTEGSLWAMDRATFRRIILKNAAQKRKMYEAFIESVPLLKSLDASERMKVVDTITTKSYEDGEQIIAQGAKADCF-FIVEAGEVRIMM 130
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Match: si:ch211-272n13.7 (protein kinase cAMP-dependent type II regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9392])

HSP 1 Score: 50.8322 bits (120), Expect = 5.447e-7
Identity = 50/227 (22.03%), Postives = 94/227 (41.41%), Query Frame = 3 
Query:  333 RTDLESNTICQWLIQNFRIFSKIQPETVDDIVQN--SRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVM 1007
            +TD + N + Q   ++  IF  +  E +  ++     + +E  E+  +I Q   G  F++I  G   IY+ T  V+     R   A NN+ S                              FGE+AL+ +  R ATII+ ++     L++  + R + KN   + +M+  F+   P+  +     + +V   +  + F     II QG+K +    +  G+ ++ M
Sbjct:  134 KTDEQRNRL-QEACKHILIFKNLDQEQMSQVLDAMFEKTVETGEH--VIDQGADGDNFYVIERGMYDIYVTTNDVS-----RCVGAYNNRGS------------------------------FGELALMYNTSRAATIIATSEGALWGLDRLTFRRIIVKNAAKKRKMYECFIETVPLLKSLDFSERLKVVDVIASKSFQDSERIIAQGEKADCFYLVESGEVRIAM 322
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005682.1 (pep scaffold:Pmarinus_7.0:GL476331:764222:769958:1 gene:ENSPMAG00000005146.1 transcript:ENSPMAT00000005682.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 49.6766 bits (117), Expect = 1.869e-6
Identity = 29/112 (25.89%), Postives = 56/112 (50.00%), Query Frame = 3 
Query:  672 IIETGSGFGEMALISDDVRNATIISDTQSQFLVLEK-TVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVV 1004
            ++  G+GFGE+AL+ D  RNATI+   +++ LV++K   +   L +    EFQ   N+  +  +F  W+    + +A   + + F     +     +   I F+++G   V+
Sbjct:   97 LLRKGAGFGEIALLKDLSRNATIVCMEETELLVVDKEDFFAYKLDQELRKEFQHRYNYFRSLELFSTWSDESLETMADHCKIEEFNHGQVVTGDTSETKNIIFVIKGCCDVL 208
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Match: EDO49032 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHT2])

HSP 1 Score: 69.707 bits (169), Expect = 6.887e-14
Identity = 42/174 (24.14%), Postives = 83/174 (47.70%), Query Frame = 3 
Query:  282 KMLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISD-DVRNATIISDTQSQFLVLEKTVYNRSL 800
            +++++    +L KP   R D +   I  W  Q   +F  ++ + + DI++N  L    ++ +++RQ E G+ F+II+ G VS+Y       +  +    +         KE+L           +G  +  +  G  FGEM ++ +   RN T+I+D  +  + +++ +Y RSL
Sbjct:    7 QIIWDLAESILSKPSEQRDDADLEHIICWFRQRSPLFKLLEDDALLDIIKNVTLTRYRKDNIIMRQGEKGNCFYIILKGSVSVY-----AKQDGDGEAATHHEQSVRSHKERL---------LLFGAELSSLRAGRSFGEMVMVDERKERNTTVIADEATMLISIDEKLYERSL 166
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Match: EDO48439 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJW7])

HSP 1 Score: 51.6026 bits (122), Expect = 6.227e-7
Identity = 45/206 (21.84%), Postives = 83/206 (40.29%), Query Frame = 3 
Query:  387 IFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVV 1004
            +FS +      DI     L++     ++I+Q + G  F+I+ +G+V +++N           +G                             +  I  G  FGE+ALI    R ATI + T  +   +++  Y R L  +Q  + +M+  F+    +  +     +  VA +L    F    +++ QG+  +    IVEG A V+
Sbjct:  130 LFSHLDENERSDIFDAMSLVKHGAGEIIIKQGDEGDNFYIVDSGEVDVFVNN----------VG----------------------------LVSTIGEGGSFGELALIYGTPRAATIKAKTDVKLWAIDRVTYRRILMGSQIRKRRMYEQFLEKVSILESLDKWERLTVADALEPTQFQDGDDVVVQGEHGDEFFIIVEGTAVVL 297
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Match: EDO32932 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STN2])

HSP 1 Score: 46.595 bits (109), Expect = 5.734e-6
Identity = 35/130 (26.92%), Postives = 57/130 (43.85%), Query Frame = 3 
Query:  453 DENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINF 842
            +++ ++I+Q  +G +F+ I++G V       +V   EE R                      T   K+   I  +  G  FGE+AL+ D  R ATII   +S+FL ++K  +N     N  +    FI F
Sbjct:   52 EQDRVIIKQGHIGVSFYFIVSGSV-------VVQRVEEDR----------------------TTGEKHNQIISEMTGGDSFGELALMHDIRRTATIICKERSEFLRVDKDDFNEVYPVNSSSILIRFIRF 152
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Match: si:ch211-272n13.7 (protein kinase cAMP-dependent type II regulatory subunit beta [Source:NCBI gene;Acc:101166375])

HSP 1 Score: 58.5362 bits (140), Expect = 1.260e-8
Identity = 46/233 (19.74%), Postives = 97/233 (41.63%), Query Frame = 3 
Query:  363 QWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD---ITQHSQQYPDLNIT 1052
            Q   ++  +F  + PE +  ++       C E   +I Q++ G  F++I +G  +I++                          K+D   K+         +G  +    FGE+AL+ +  R ATII+ +      L++  + R + KN   + +++  F+   P+  +     + +V   L  +++    +II QGD  +    +  GQ ++ M    +T+  Q+  ++ I 
Sbjct:  136 QEACRDILLFKNLDPEEISQVLDAMFEKFCTEGEHIIDQDDDGDNFYVIESGTFNIFV--------------------------KVDGIEKL---------VGCYDNRGSFGELALMYNTPRAATIIATSPGALWCLDRLTFRRIIVKNNAKKRRLYEAFIETLPLLTSLETSERMKVVDVLSTRVYNDSQQIIAQGDLADCFYIVESGQVRITMKRSRMTKKDQEEEEVEIA 333
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Match: si:ch211-272n13.7 (protein kinase cAMP-dependent type II regulatory subunit beta [Source:NCBI gene;Acc:101166375])

HSP 1 Score: 54.299 bits (129), Expect = 2.575e-7
Identity = 49/239 (20.50%), Postives = 101/239 (42.26%), Query Frame = 3 
Query:  375 QNFRIFSKIQPETVDDIV----QNSRLLE------CDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMD---ITQHSQQYPDLNIT 1052
            + F+  S  QP+  D +     + S++L+      C E   +I Q++ G  F++I +G  +I++                          K+D   K+         +G  +    FGE+AL+ +  R ATII+ +      L++  + R + KN   + +++  F+   P+  +     + +V   L  +++    +II QGD  +    +  GQ ++ M    +T+  Q+  ++ I 
Sbjct:  123 RGFKFVSSPQPKMFDILFIFQEEISQVLDAMFEKFCTEGEHIIDQDDDGDNFYVIESGTFNIFV--------------------------KVDGIEKL---------VGCYDNRGSFGELALMYNTPRAATIIATSPGALWCLDRLTFRRIIVKNNAKKRRLYEAFIETLPLLTSLETSERMKVVDVLSTRVYNDSQQIIAQGDLADCFYIVESGQVRITMKRSRMTKKDQEEEEVEIA 326
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Match: prkar2aa (cAMP-dependent protein kinase type II-alpha regulatory subunit [Source:NCBI gene;Acc:101159349])

HSP 1 Score: 51.6026 bits (122), Expect = 1.868e-6
Identity = 30/117 (25.64%), Postives = 55/117 (47.01%), Query Frame = 3 
Query:  657 GNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVM 1007
            G  +G       FGE+AL+ +  R ATII+  +     L++  + R + KN   + +M+  F+ + P+     P  + ++   L  + F     II QG+K      +  G+ K++M
Sbjct:  185 GKCVGQYNNKGSFGELALMYNTPRAATIIATQEGALWGLDRATFRRLIVKNNAKKRRMYETFIESVPLLKTLEPNERMKIVDVLGMKQFLDGERIIAQGEKAECFYIVESGEVKIMM 301
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000052390.1 (SMESG000052390.1)

HSP 1 Score: 1048.5 bits (2710), Expect = 0.000e+0
Identity = 555/557 (99.64%), Postives = 555/557 (99.64%), Query Frame = 3 
Query:  285 MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDHLVQTKSLSTLQNGMLIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESEKLEFXXXXXXXXXXXDFITRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSKDGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKKLHTLADFVLPSNTNYDSKMVTDFEMPINASIT 1955
            MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEE RIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMF NFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDHLVQTKSLSTLQNGMLIQSLEKVKKLKHLELSLVGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRLVKLVLNKNLKSESEKLEFQQKKISISKQQDFITRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSKDGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKKLHTLADFVLPSNTNYDSKMVTDFEMPINASIT
Sbjct:    1 MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEDRIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFNNFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNITDHLVQTKSLSTLQNGMLIQSLEKVKKLKHLELSLVGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRLVKLVLNKNLKSESEKLEFQQKKISISKQQDFITRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSKDGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPKLRRFIKKETDIVKPGKTILLKPKKLHTLADFVLPSNTNYDSKMVTDFEMPINASIT 557
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 283.493 bits (724), Expect = 3.947e-85
Identity = 198/601 (32.95%), Postives = 312/601 (51.91%), Query Frame = 3 
Query:  288 LFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNIT--------------DHLVQTKSLSTLQNGM-----LIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESE------KLEFXXXXXXXXXXXDFITRGPIIDMFGPGTVFYRNRLLRQKNQ--KKRSKSNEPKLKS-------------------QSTTDDSKDGKYNPMITQ------------------LEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPK--------LRRFIKKETDIVK---PGKTILLKPKK 1859
            ++  V+  + KP  DRT  E  +I  WL +   +F  ++ E +++I+++    E   + ++IRQ + G  F++++ G+VSI+INTE V + PE+A +       T  K +      K  DR++YGNFI I+++G  FGE+ALI+ D VRNA+II+D  +  LV+ + +YNRS+++ Q  EF   ++FV NS +F NW  +YK+QVA SLR++ F F + +I QG+  NG+ FI+ G AKVV++  QH  QYP LN T              D  V  ++   L N +      I++ ++  +       + G GEIIGDIE    L T   ++I  E TEVY L  +N+ERL   KKN  T  +L+K A  K+  +  R  ++ IP   RL +++ ++  +   E      K+E  +          F  RGP+ID++GPG+VFYRNR LR++ Q  +++ +  E  LK                    +++ DDS+DG+    I+                        +  DWET    L++LE+ + +W  S SS T +            L+RF  K+ D+ K   PGK I ++PKK
Sbjct:    4 MYEMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIFINTEAVPDNPEDANVVV-----TEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATINNEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVKG-GEIIGDIEQGLELTTYASSVITIEATEVYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRLEFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNF-FQHRGPLIDLYGPGSVFYRNRQLRKEKQIIERKRQITEMALKGRRGNQRGGVSIGMFGNEKFENSDDDSEDGEEINTISHFNNYNNNQNVDCIDYLKGFNAHDSMNDWETGSVHLQSLEDRLRNWFLSVSSLTNDKRAGRAIEHYTILKRF--KQEDLEKKIIPGKKIFMRPKK 595
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 283.108 bits (723), Expect = 4.869e-85
Identity = 198/601 (32.95%), Postives = 312/601 (51.91%), Query Frame = 3 
Query:  288 LFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNIT--------------DHLVQTKSLSTLQNGM-----LIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESE------KLEFXXXXXXXXXXXDFITRGPIIDMFGPGTVFYRNRLLRQKNQ--KKRSKSNEPKLKS-------------------QSTTDDSKDGKYNPMITQ------------------LEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPK--------LRRFIKKETDIVK---PGKTILLKPKK 1859
            ++  V+  + KP  DRT  E  +I  WL +   +F  ++ E +++I+++    E   + ++IRQ + G  F++++ G+VSI+INTE V + PE+A +       T  K +      K  DR++YGNFI I+++G  FGE+ALI+ D VRNA+II+D  +  LV+ + +YNRS+++ Q  EF   ++FV NS +F NW  +YK+QVA SLR++ F F + +I QG+  NG+ FI+ G AKVV++  QH  QYP LN T              D  V  ++   L N +      I++ ++  +       + G GEIIGDIE    L T   ++I  E TEVY L  +N+ERL   KKN  T  +L+K A  K+  +  R  ++ IP   RL +++ ++  +   E      K+E  +          F  RGP+ID++GPG+VFYRNR LR++ Q  +++ +  E  LK                    +++ DDS+DG+    I+                        +  DWET    L++LE+ + +W  S SS T +            L+RF  K+ D+ K   PGK I ++PKK
Sbjct:    1 MYEMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIFINTEAVPDNPEDANVVV-----TEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATINNEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVKG-GEIIGDIEQGLELTTYASSVITIEATEVYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRLEFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNF-FQHRGPLIDLYGPGSVFYRNRQLRKEKQIIERKRQITEMALKGRRGNQRGGVSIGMFGNEKFENSDDDSEDGEEINTISHFNNYNNNQNVDCIDYLKGFNAHDSMNDWETGSVHLQSLEDRLRNWFLSVSSLTNDKRAGRAIEHYTILKRF--KQEDLEKKIIPGKKIFMRPKK 592
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 283.493 bits (724), Expect = 1.428e-84
Identity = 198/601 (32.95%), Postives = 312/601 (51.91%), Query Frame = 3 
Query:  288 LFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNIT--------------DHLVQTKSLSTLQNGM-----LIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESE------KLEFXXXXXXXXXXXDFITRGPIIDMFGPGTVFYRNRLLRQKNQ--KKRSKSNEPKLKS-------------------QSTTDDSKDGKYNPMITQ------------------LEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPK--------LRRFIKKETDIVK---PGKTILLKPKK 1859
            ++  V+  + KP  DRT  E  +I  WL +   +F  ++ E +++I+++    E   + ++IRQ + G  F++++ G+VSI+INTE V + PE+A +       T  K +      K  DR++YGNFI I+++G  FGE+ALI+ D VRNA+II+D  +  LV+ + +YNRS+++ Q  EF   ++FV NS +F NW  +YK+QVA SLR++ F F + +I QG+  NG+ FI+ G AKVV++  QH  QYP LN T              D  V  ++   L N +      I++ ++  +       + G GEIIGDIE    L T   ++I  E TEVY L  +N+ERL   KKN  T  +L+K A  K+  +  R  ++ IP   RL +++ ++  +   E      K+E  +          F  RGP+ID++GPG+VFYRNR LR++ Q  +++ +  E  LK                    +++ DDS+DG+    I+                        +  DWET    L++LE+ + +W  S SS T +            L+RF  K+ D+ K   PGK I ++PKK
Sbjct:    4 MYEMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIFINTEAVPDNPEDANVVV-----TEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATINNEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVKG-GEIIGDIEQGLELTTYASSVITIEATEVYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRLEFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNF-FQHRGPLIDLYGPGSVFYRNRQLRKEKQIIERKRQITEMALKGRRGNQRGGVSIGMFGNEKFENSDDDSEDGEEINTISHFNNYNNNQNVDCIDYLKGFNAHDSMNDWETGSVHLQSLEDRLRNWFLSVSSLTNDKRAGRAIEHYTILKRF--KQEDLEKKIIPGKKIFMRPKK 595
[Close]
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 283.493 bits (724), Expect = 1.515e-84
Identity = 198/601 (32.95%), Postives = 312/601 (51.91%), Query Frame = 3 
Query:  288 LFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQNSRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTE-PEEARIGSASNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDD-VRNATIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRYKKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQYPDLNIT--------------DHLVQTKSLSTLQNGM-----LIQXXXXXXXXXXXXXXXXGPGEIIGDIEHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAEQKLLSQFYRPSYQRIPLIGRXXXXXXXXXXXSESE------KLEFXXXXXXXXXXXDFITRGPIIDMFGPGTVFYRNRLLRQKNQ--KKRSKSNEPKLKS-------------------QSTTDDSKDGKYNPMITQ------------------LEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVPK--------LRRFIKKETDIVK---PGKTILLKPKK 1859
            ++  V+  + KP  DRT  E  +I  WL +   +F  ++ E +++I+++    E   + ++IRQ + G  F++++ G+VSI+INTE V + PE+A +       T  K +      K  DR++YGNFI I+++G  FGE+ALI+ D VRNA+II+D  +  LV+ + +YNRS+++ Q  EF   ++FV NS +F NW  +YK+QVA SLR++ F F + +I QG+  NG+ FI+ G AKVV++  QH  QYP LN T              D  V  ++   L N +      I++ ++  +       + G GEIIGDIE    L T   ++I  E TEVY L  +N+ERL   KKN  T  +L+K A  K+  +  R  ++ IP   RL +++ ++  +   E      K+E  +          F  RGP+ID++GPG+VFYRNR LR++ Q  +++ +  E  LK                    +++ DDS+DG+    I+                        +  DWET    L++LE+ + +W  S SS T +            L+RF  K+ D+ K   PGK I ++PKK
Sbjct:    1 MYEMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIFINTEAVPDNPEDANVVV-----TEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATINNEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVKG-GEIIGDIEQGLELTTYASSVITIEATEVYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRLEFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNF-FQHRGPLIDLYGPGSVFYRNRQLRKEKQIIERKRQITEMALKGRRGNQRGGVSIGMFGNEKFENSDDDSEDGEEINTISHFNNYNNNQNVDCIDYLKGFNAHDSMNDWETGSVHLQSLEDRLRNWFLSVSSLTNDKRAGRAIEHYTILKRF--KQEDLEKKIIPGKKIFMRPKK 592
The following BLAST results are available for this feature:
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PRKG22.115e-627.91protein kinase cGMP-dependent 2 [Source:HGNC Symbo... [more]
PRKG22.338e-627.91protein kinase cGMP-dependent 2 [Source:HGNC Symbo... [more]
PRKG22.338e-627.91protein kinase cGMP-dependent 2 [Source:HGNC Symbo... [more]
PRKAR2B6.429e-621.49protein kinase cAMP-dependent type II regulatory s... [more]
PRKAR2B6.429e-621.49protein kinase cAMP-dependent type II regulatory s... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
kin-21.782e-822.73cAMP-dependent protein kinase regulatory subunit ... [more]
kin-22.410e-822.73cAMP-dependent protein kinase regulatory subunit ... [more]
kin-23.323e-822.73cAMP-dependent protein kinase regulatory subunit ... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pka-R21.614e-822.54gene:FBgn0022382 transcript:FBtr0112902[more]
Pka-R21.932e-822.54gene:FBgn0022382 transcript:FBtr0088437[more]
Pka-R21.932e-822.54gene:FBgn0022382 transcript:FBtr0088438[more]
Pka-R22.523e-822.54gene:FBgn0022382 transcript:FBtr0112901[more]
Pka-R13.669e-624.61gene:FBgn0259243 transcript:FBtr0302638[more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
prkar2aa9.819e-725.20protein kinase, cAMP-dependent, regulatory, type I... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ptafr2.974e-731.62platelet activating factor receptor [Source:Xenbas... [more]
fgf16.994e-623.68fibroblast growth factor 1 [Source:Xenbase;Acc:XB-... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cnbd21.609e-724.00cyclic nucleotide binding domain containing 2 [Sou... [more]
Cnbd28.903e-726.23cyclic nucleotide binding domain containing 2 [Sou... [more]
Cnbd29.067e-725.27cyclic nucleotide binding domain containing 2 [Sou... [more]
Prkg21.637e-627.91protein kinase, cGMP-dependent, type II [Source:MG... [more]
Prkg21.904e-627.91protein kinase, cGMP-dependent, type II [Source:MG... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q86ZN7|KAPR_HYPAT2.193e-925.14cAMP-dependent protein kinase regulatory subunit O... [more]
sp|Q01386|KAPR_NEUCR2.393e-922.35cAMP-dependent protein kinase regulatory subunit O... [more]
sp|Q9C1C2|KAPR_COLOR3.150e-921.90cAMP-dependent protein kinase regulatory subunit O... [more]
sp|O14448|KAPR_MAGO78.590e-923.78cAMP-dependent protein kinase regulatory subunit O... [more]
sp|O59922|KAPR_EMENI2.777e-824.18cAMP-dependent protein kinase regulatory subunit O... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267DMG68.348e-9234.58Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267FVW01.874e-9135.60Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8IH134.405e-8834.58Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8INU32.543e-8734.71Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267GYH01.669e-7431.27Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
prkar2aa1.076e-723.87protein kinase, cAMP-dependent, regulatory, type I... [more]
prkg26.685e-627.13protein kinase cGMP-dependent 2 [Source:NCBI gene;... [more]
prkg28.500e-627.13protein kinase cGMP-dependent 2 [Source:NCBI gene;... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
prkar2aa2.514e-725.00protein kinase, cAMP-dependent, regulatory, type I... [more]
si:ch211-272n13.75.447e-722.03protein kinase cAMP-dependent type II regulatory s... [more]
ENSPMAT00000005682.11.869e-625.89pep scaffold:Pmarinus_7.0:GL476331:764222:769958:1... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO490326.887e-1424.14Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO484396.227e-721.84Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO329325.734e-626.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
si:ch211-272n13.71.260e-819.74protein kinase cAMP-dependent type II regulatory s... [more]
si:ch211-272n13.72.575e-720.50protein kinase cAMP-dependent type II regulatory s... [more]
prkar2aa1.868e-625.64cAMP-dependent protein kinase type II-alpha regula... [more]
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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000052390.10.000e+099.64SMESG000052390.1[more]
SMESG000078515.13.947e-8532.95SMESG000078515.1[more]
SMESG000078515.14.869e-8532.95SMESG000078515.1[more]
SMESG000078515.11.428e-8432.95SMESG000078515.1[more]
SMESG000078515.11.515e-8432.95SMESG000078515.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002366 ID=SMED30002366|Name=cAMP-dependent protein kinase regulatory subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=2286bp
AATCTTAAAGTTTACTATCAAAAAATTTCTATTTTTATCATTCTGGAGAA
TCTATTTCTAATGGTTATACGCTGGCAGCAATCTCTATTATTCTAAATTT
CTATTATTCTGCTGGCGATCCTGCAGTATCTATTAGTTTTGAAAATTCAA
CCAATCAGAATCTCTCATCAATACTTCTGTGAATTCTGACTTGATTCCGT
AAATATACATATTTATATGTTTGACTTAGTTGGAATGAGTCTAATTTCAA
AAATTCCAAATTATTGATTGACTCGATTTGAAAAATGCTTTTTAATTTTG
TGATTGATTTACTCAAGAAGCCTTTACTGGATCGAACTGACTTGGAGTCC
AACACGATTTGCCAATGGTTGATCCAGAATTTTCGAATTTTCTCCAAAAT
TCAACCAGAAACTGTTGATGATATTGTTCAAAATTCAAGGCTACTAGAAT
GTGACGAAAATACTTTGTTGATAAGGCAGAATGAATTGGGCTCGACATTC
TTTATCATTATTAATGGAAAGGTTTCTATTTATATTAACACTGAGCTTGT
AACAGAACCAGAAGAGGCCCGAATCGGTTCAGCATCAAACAATAAAACAT
CCCCTAAAAAAGAAAAATTGGATAGCTATCCCAAAGTGACAGATAGAAAT
AAGTATGGAAATTTTATTGGAATCATTGAAACCGGAAGTGGATTTGGTGA
AATGGCTCTGATCAGTGATGATGTTCGAAATGCTACGATTATATCCGATA
CCCAGTCCCAGTTCCTTGTTTTAGAGAAAACAGTTTATAATCGTAGTCTT
CGGAAAAATCAAGAAGCCGAATTTCAAATGTTCATTAATTTCGTCAACAA
CTCGCCAGTTTTCTACAATTGGGCACCAAGATATAAAAAACAAGTGGCAA
TGAGTTTGCGGCGTCAGATATTTCCGTTTGAAGTAGAAATCATCAAACAG
GGCGACAAAATAAATGGAATAGGATTTATAGTTGAGGGTCAAGCAAAGGT
AGTCATGGATATCACTCAACATTCACAACAATATCCAGATCTGAATATCA
CTGATCATTTAGTTCAAACCAAATCTTTGTCAACTTTGCAGAATGGAATG
TTAATTCAGTCATTGGAAAAAGTGAAAAAATTGAAACATCTCGAGCTATC
TTTAGTGGGACCTGGAGAAATAATTGGGGATATTGAGCATGCATTTGGAT
TAGATACAAGCTGTAAAACTTTAATTCCAACAGAAAATACGGAAGTGTAC
TTTTTATCCGAAAGAAACTATGAAAGATTGTTGACATCAAAGAAAAACCA
AACCACAGCAGAAATGCTGCAAAAATGGGCCGAACAAAAACTGTTAAGTC
AATTTTATCGGCCGTCTTATCAGCGAATTCCATTAATTGGGAGATTAGTA
AAATTGGTTCTCAACAAAAATTTGAAATCGGAAAGTGAAAAACTAGAATT
TCAGCAGAAAAAGATATCAATTTCCAAACAACAGGATTTCATTACTCGGG
GCCCAATAATTGACATGTTTGGACCTGGAACTGTCTTTTACAGAAATCGT
TTATTGAGACAAAAAAATCAGAAAAAACGCAGCAAATCTAACGAGCCAAA
ATTGAAATCGCAATCCACAACCGATGACAGCAAAGATGGGAAATATAACC
CCATGATAACGCAACTGGAAAAGGATCCGACATTCCTGGACTGGGAAACG
AGTGGCAATAAACTGGAAACCCTGGAAAATCACATCGAATCATGGCTGAA
CTCTGATTCGAGCTTCACTAAAAATTCTGTGCCGAAACTGAGGAGATTTA
TTAAAAAAGAAACCGATATTGTCAAGCCTGGAAAAACCATATTATTAAAA
CCAAAGAAGCTCCACACGTTGGCAGACTTTGTCCTTCCGAGCAATACAAA
TTACGACAGCAAAATGGTTACGGATTTCGAAATGCCAATCAACGCCTCCA
TTACCTGAGGTTGGCAAGTGGTCGAATCCTGAGCCTATGAGGGTCCGTAT
TTTGTTTATACTGACCCTAAATTATTATTCAATCAGATTTCAATATAGTA
GTCATGATTTGTGAAAACAGAATTTTATAATCTCTCTTTATTTGATTGAC
TTGTGGACCTTTTTTGGTGATTACACATGCAAAACTTGTTATTGCCGACG
GCGAGTCGCCAAATTAAAGTGAAAAGACAAAATTTTTATTTTTTTGTTTC
AGTGTGAAATGTCAATCTTTTGTTTATTGACAAAACTCTGATTTTAAATT
TTGTTTTGTTCTGTCTGGTAAAACAAACATTTGTTG
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protein sequence of SMED30002366-orf-1

>SMED30002366-orf-1 ID=SMED30002366-orf-1|Name=SMED30002366-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=558bp
MLFNFVIDLLKKPLLDRTDLESNTICQWLIQNFRIFSKIQPETVDDIVQN
SRLLECDENTLLIRQNELGSTFFIIINGKVSIYINTELVTEPEEARIGSA
SNNKTSPKKEKLDSYPKVTDRNKYGNFIGIIETGSGFGEMALISDDVRNA
TIISDTQSQFLVLEKTVYNRSLRKNQEAEFQMFINFVNNSPVFYNWAPRY
KKQVAMSLRRQIFPFEVEIIKQGDKINGIGFIVEGQAKVVMDITQHSQQY
PDLNITDHLVQTKSLSTLQNGMLIQSLEKVKKLKHLELSLVGPGEIIGDI
EHAFGLDTSCKTLIPTENTEVYFLSERNYERLLTSKKNQTTAEMLQKWAE
QKLLSQFYRPSYQRIPLIGRLVKLVLNKNLKSESEKLEFQQKKISISKQQ
DFITRGPIIDMFGPGTVFYRNRLLRQKNQKKRSKSNEPKLKSQSTTDDSK
DGKYNPMITQLEKDPTFLDWETSGNKLETLENHIESWLNSDSSFTKNSVP
KLRRFIKKETDIVKPGKTILLKPKKLHTLADFVLPSNTNYDSKMVTDFEM
PINASIT*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000418head
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR000595cNMP-bd_dom
IPR014710RmlC-like_jellyroll
IPR018490cNMP-bd-like
Vocabulary: molecular function
TermDefinition
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000595Cyclic nucleotide-binding domainSMARTSM00100cnmp_10coord: 35..187
e-value: 8.7E-9
score: 45.2
IPR000595Cyclic nucleotide-binding domainPROSITEPS50042CNMP_BINDING_3coord: 35..189
score: 19.371
IPR000595Cyclic nucleotide-binding domainPROSITEPS50042CNMP_BINDING_3coord: 192..242
score: 7.227
IPR000595Cyclic nucleotide-binding domainCDDcd00038CAP_EDcoord: 35..182
e-value: 8.84301E-14
score: 65.8102
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 430..448
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 425..454
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 94..115
NoneNo IPR availablePANTHERPTHR11635CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAINcoord: 4..471
NoneNo IPR availablePANTHERPTHR11635:SF152CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNITcoord: 4..471
IPR018490Cyclic nucleotide-binding-likeSUPERFAMILYSSF51206cAMP-binding domain-likecoord: 178..336
IPR018490Cyclic nucleotide-binding-likeSUPERFAMILYSSF51206cAMP-binding domain-likecoord: 24..182