Helicase with zinc finger domain 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002317 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Human
Match: HELZ2 (helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021]) HSP 1 Score: 176.407 bits (446), Expect = 2.683e-43 Identity = 112/307 (36.48%), Postives = 167/307 (54.40%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKP--PP----------VLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPC--AGAPYNLDS---EGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIF-RNYNICLKKAL--QKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFY 4904
LN Q +A+ + FT+I GPPGTGKT+VG I +W+ N+ +P PP +LYCGPSN+SV+V+A L++ R K LR+++ +FP G+ L EG P + L+ I LH +R+ PY+ ++ + T R + ++F R + KK L ++ E+ +E+IL T + + L+ L V QI++DE GM +EPE L P + + + +VL+GDHKQLRP+V + + L+ SLFER ++ MLDTQYRMH IC FPS+ FY
Sbjct: 2153 LNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLR---RMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDT------------RLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAH----MLDTQYRMHEGICAFPSVAFY 2440 HSP 2 Score: 110.153 bits (274), Expect = 4.037e-23 Identity = 65/169 (38.46%), Postives = 100/169 (59.17%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
++F H QG E++ +S G+ SK+N EV EVV+ + L + ++ Q I V+T Y Q ++K L GI + VS++ KSQGSE YV+ STVR+ D+D+ PT W+ K+LGF+ D NQ NVA+TRA++GL ++G+ LL +W++ +D
Sbjct: 2467 VIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVE----PQDIAVLTPYNAQASEISKA----LRREGIAGVA-VSSITKSQGSEWRYVLVSTVRTCAK-SDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLD 2625
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Human
Match: HELZ2 (helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021]) HSP 1 Score: 171.014 bits (432), Expect = 1.156e-41 Identity = 112/307 (36.48%), Postives = 167/307 (54.40%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKP--PP----------VLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPC--AGAPYNL---DSEGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIF-RNYNICLKKAL--QKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFY 4904
LN Q +A+ + FT+I GPPGTGKT+VG I +W+ N+ +P PP +LYCGPSN+SV+V+A L++ R K LR+++ +FP G+ L EG P + L+ I LH +R+ PY+ ++ + T R + ++F R + KK L ++ E+ +E+IL T + + L+ L V QI++DE GM +EPE L P + + + +VL+GDHKQLRP+V + + L+ SLFER ++ MLDTQYRMH IC FPS+ FY
Sbjct: 1584 LNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLR---RMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDT------------RLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAH----MLDTQYRMHEGICAFPSVAFY 1871 HSP 2 Score: 111.694 bits (278), Expect = 1.356e-23 Identity = 65/169 (38.46%), Postives = 100/169 (59.17%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
++F H QG E++ +S G+ SK+N EV EVV+ + L + ++ Q I V+T Y Q ++K L GI + VS++ KSQGSE YV+ STVR+ D+D+ PT W+ K+LGF+ D NQ NVA+TRA++GL ++G+ LL +W++ +D
Sbjct: 1898 VIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVE----PQDIAVLTPYNAQASEISKA----LRREGIAGV-AVSSITKSQGSEWRYVLVSTVRTCAK-SDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLD 2056
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Human
Match: UPF1 (UPF1 RNA helicase and ATPase [Source:HGNC Symbol;Acc:HGNC:9962]) HSP 1 Score: 150.984 bits (380), Expect = 8.351e-36 Identity = 162/605 (26.78%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 420 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 898
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Human
Match: UPF1 (UPF1 RNA helicase and ATPase [Source:HGNC Symbol;Acc:HGNC:9962]) HSP 1 Score: 150.599 bits (379), Expect = 1.067e-35 Identity = 162/605 (26.78%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 431 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 909
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Human
Match: DNA2 (DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939]) HSP 1 Score: 80.1073 bits (196), Expect = 8.778e-15 Identity = 98/375 (26.13%), Postives = 154/375 (41.07%), Query Frame = 3
Query: 4506 QIFRNYNICLKKALQKEL---EIGNYEIILSTAAGSCKKLLESLKVTQI-ILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVG 5618
Q F IC K+++ E+ N ++I++T + S K+ I+DE S+P LGP + VL+GDH+QL P+V +R A+A ++ SLF+RL ++K + L QYRM+ I + Y E G D NA N + + K +L + + +D W+ G NN C P EK SN E +++ +L +K + I +I YR Q +N + + S G+ + V+TV K QG + V+ S VRS +K+ T G + K D + NVA+TRA+ L ++G
Sbjct: 32 QQFTEQEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFS---RRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSA-VVQLTVQYRMNSKIMSLSNKLTYEGKLECGS---------------DKVANAVIN----LRHFKDVKLELEF-YADYSDNPWLMGVFEPNNPVCFLNTDKVPAPEQVEK----------------------GGVSNVTEAKLIVFLTSIF----VKAGCSPSDIGIIAPYRQQLKIINDL---LARSIGMVE---VNTVDKYQGRDKSIVLVSFVRS-------NKDGTVGELLK------DWRRLNVAITRAKHKLILLG 337
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Celegans
Match: smg-2 (Regulator of nonsense transcripts 1 [Source:UniProtKB/Swiss-Prot;Acc:O76512]) HSP 1 Score: 140.969 bits (354), Expect = 3.691e-33 Identity = 152/547 (27.79%), Postives = 233/547 (42.60%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQE-YNLNKM-CQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKR 5681
LN Q A++ +LI GPPGTGKT+V I Y ++ K + VL C PSN +V+ +AEK+ KT K++R+ CA + + SE YL L ++ G +KL + + + EF R LK+ + EL + ++I T + + L ++ +++DE +EPE L M ++ LVL+GDH QL P+V + A L+ SLFERL + L QYRMHP + EFPS FY+ S ++ G+ +N H+ D W P + F H G E E+S + S +++ VE L+ K+IK I VIT Y Q + +N M Q LNS +++ +++V QG E DY+I + VRS N G +GF++D + NVA+TRA+ GL +VGN+ +L+ + +W I+ K +
Sbjct: 446 LNSSQMQAVKQVLTRPLSLIQGPPGTGKTVVSATIVY--HLVQKTEGN---VLVCSPSNIAVDHLAEKIHKT----GLKVVRL-----------CARSREH--SETTVPYL---TLQHQLKVMGGAELQKLIQLKD---------EAGELEFKDDLRYMQ--LKRVKEHEL-LAAADVICCTCSSAADARLSKIRTRTVLIDESTQATEPEILVSIMRG--VRQLVLVGDHCQLGPVVICKKAAIAGLSQSLFERLVLLGIR-PFRLQVQYRMHPVLSEFPSNVFYDGSLQN--------------GVTEND-----------------------RHMTGVDWHW---------------------PKPNKPAFFWHCSGSE---ELSASGTSFLNRTEAANVE-------KLVSKLIKAGVQPHQIGVITPYEGQRSFIVNYMHTQGTLNS-KLYENVEIASVDAFQGREKDYIIVTCVRS---------NDILG-----IGFLSDPRRLNVAITRAKYGLVLVGNAKVLARHDLWHELINHYKSK 869
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Celegans
Match: smg-2 (Regulator of nonsense transcripts 1 [Source:UniProtKB/Swiss-Prot;Acc:O76512]) HSP 1 Score: 140.969 bits (354), Expect = 3.691e-33 Identity = 152/547 (27.79%), Postives = 233/547 (42.60%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQE-YNLNKM-CQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKR 5681
LN Q A++ +LI GPPGTGKT+V I Y ++ K + VL C PSN +V+ +AEK+ KT K++R+ CA + + SE YL L ++ G +KL + + + EF R LK+ + EL + ++I T + + L ++ +++DE +EPE L M ++ LVL+GDH QL P+V + A L+ SLFERL + L QYRMHP + EFPS FY+ S ++ G+ +N H+ D W P + F H G E E+S + S +++ VE L+ K+IK I VIT Y Q + +N M Q LNS +++ +++V QG E DY+I + VRS N G +GF++D + NVA+TRA+ GL +VGN+ +L+ + +W I+ K +
Sbjct: 446 LNSSQMQAVKQVLTRPLSLIQGPPGTGKTVVSATIVY--HLVQKTEGN---VLVCSPSNIAVDHLAEKIHKT----GLKVVRL-----------CARSREH--SETTVPYL---TLQHQLKVMGGAELQKLIQLKD---------EAGELEFKDDLRYMQ--LKRVKEHEL-LAAADVICCTCSSAADARLSKIRTRTVLIDESTQATEPEILVSIMRG--VRQLVLVGDHCQLGPVVICKKAAIAGLSQSLFERLVLLGIR-PFRLQVQYRMHPVLSEFPSNVFYDGSLQN--------------GVTEND-----------------------RHMTGVDWHW---------------------PKPNKPAFFWHCSGSE---ELSASGTSFLNRTEAANVE-------KLVSKLIKAGVQPHQIGVITPYEGQRSFIVNYMHTQGTLNS-KLYENVEIASVDAFQGREKDYIIVTCVRS---------NDILG-----IGFLSDPRRLNVAITRAKYGLVLVGNAKVLARHDLWHELINHYKSK 869
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Celegans
Match: smg-2 (Regulator of nonsense transcripts 1 [Source:UniProtKB/Swiss-Prot;Acc:O76512]) HSP 1 Score: 140.969 bits (354), Expect = 3.691e-33 Identity = 152/547 (27.79%), Postives = 233/547 (42.60%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQE-YNLNKM-CQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKR 5681
LN Q A++ +LI GPPGTGKT+V I Y ++ K + VL C PSN +V+ +AEK+ KT K++R+ CA + + SE YL L ++ G +KL + + + EF R LK+ + EL + ++I T + + L ++ +++DE +EPE L M ++ LVL+GDH QL P+V + A L+ SLFERL + L QYRMHP + EFPS FY+ S ++ G+ +N H+ D W P + F H G E E+S + S +++ VE L+ K+IK I VIT Y Q + +N M Q LNS +++ +++V QG E DY+I + VRS N G +GF++D + NVA+TRA+ GL +VGN+ +L+ + +W I+ K +
Sbjct: 446 LNSSQMQAVKQVLTRPLSLIQGPPGTGKTVVSATIVY--HLVQKTEGN---VLVCSPSNIAVDHLAEKIHKT----GLKVVRL-----------CARSREH--SETTVPYL---TLQHQLKVMGGAELQKLIQLKD---------EAGELEFKDDLRYMQ--LKRVKEHEL-LAAADVICCTCSSAADARLSKIRTRTVLIDESTQATEPEILVSIMRG--VRQLVLVGDHCQLGPVVICKKAAIAGLSQSLFERLVLLGIR-PFRLQVQYRMHPVLSEFPSNVFYDGSLQN--------------GVTEND-----------------------RHMTGVDWHW---------------------PKPNKPAFFWHCSGSE---ELSASGTSFLNRTEAANVE-------KLVSKLIKAGVQPHQIGVITPYEGQRSFIVNYMHTQGTLNS-KLYENVEIASVDAFQGREKDYIIVTCVRS---------NDILG-----IGFLSDPRRLNVAITRAKYGLVLVGNAKVLARHDLWHELINHYKSK 869
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Celegans
Match: Y106G6D.5 (pep chromosome:WBcel235:I:10119209:10121815:-1 gene:WBGene00014965.1 transcript:Y106G6D.5b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y106G6D.5) HSP 1 Score: 61.6178 bits (148), Expect = 4.637e-9 Identity = 80/293 (27.30%), Postives = 119/293 (40.61%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTL--IWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLE-SLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYK--SKEKYCIMLDTQYRMHPSICEFPSIHFYND 4910
LN Q A+ + N + L I GPPGTGKT V IA I+++ K VL C P++ +V + T GR M + P A L C L + F K A KL E + S + +K + + N + +L + + + S +KL E +I+DE C+EP P + K L+L+GD KQL +V S A +SL E+L + S I+L+ QYRM+ I + + FY +
Sbjct: 131 LNPSQVAAVSAAMNTQRNLLCIQGPPGTGKTRV---IA---EIVHQLMKKKKKVLVCAPTHVAVR---NAMDATTGR-------------MIEEMPEEKAEQQL----C--LLANTKDEFQNHKS----ASKLEEIKKQLSTMSTSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFS-----TLGTSSIQKLPEYHWNADVMIVDEAAQCTEPATWVPVLTTPSCKKLILVGDQKQLPAVVLSDKAMKGNFKLSLMEKLAEEFSSNNINILLNEQYRMNKKIMNWSNEVFYEN 386
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Celegans
Match: Y106G6D.5 (pep chromosome:WBcel235:I:10119209:10122171:-1 gene:WBGene00014965.1 transcript:Y106G6D.5a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y106G6D.5) HSP 1 Score: 61.2326 bits (147), Expect = 6.652e-9 Identity = 80/293 (27.30%), Postives = 119/293 (40.61%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTL--IWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLE-SLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYK--SKEKYCIMLDTQYRMHPSICEFPSIHFYND 4910
LN Q A+ + N + L I GPPGTGKT V IA I+++ K VL C P++ +V + T GR M + P A L C L + F K A KL E + S + +K + + N + +L + + + S +KL E +I+DE C+EP P + K L+L+GD KQL +V S A +SL E+L + S I+L+ QYRM+ I + + FY +
Sbjct: 222 LNPSQVAAVSAAMNTQRNLLCIQGPPGTGKTRV---IA---EIVHQLMKKKKKVLVCAPTHVAVR---NAMDATTGR-------------MIEEMPEEKAEQQL----C--LLANTKDEFQNHKS----ASKLEEIKKQLSTMSTSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFS-----TLGTSSIQKLPEYHWNADVMIVDEAAQCTEPATWVPVLTTPSCKKLILVGDQKQLPAVVLSDKAMKGNFKLSLMEKLAEEFSSNNINILLNEQYRMNKKIMNWSNEVFYEN 477
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Fly
Match: Upf1 (gene:FBgn0030354 transcript:FBtr0342744) HSP 1 Score: 148.288 bits (373), Expect = 2.985e-35 Identity = 156/551 (28.31%), Postives = 230/551 (41.74%), Query Frame = 3
Query: 4044 NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMC--QEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKR 5681
+LN Q A++++ +LI GPPGTGKT+ I Y L+ VL C PSN +V+ + EK+ +T R C K +S + F +ALH +R +L + Q + + + + K + RN LK+A + +L + ++I T G+ L +K T I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + L+ QYRMHP + +FPS FY S ++G VC ED R LK D F P + F+ TQGQE+ GS S N E V+ + LK IK + I +IT Y Q L + Q L+S ++ +++V QG E D +I S VRS N G +GF+ D + NVALTRA+ G+ IVGN +L+ ++W ++ K R
Sbjct: 451 DLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGT-----VLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSF-----------------------LALHNQIRN--METNSELKKLQQLKDETGELSSADEKRY----RN----LKRAAENQL-LEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIR-PFRLEVQYRMHPELSQFPSNFFYEGSLQNG-------VC---------------------------AEDRR-----------------------LKLD--FPWPQPERPMFFLVTQGQEE------IAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQ----IGIITPYEGQRAYLVQYMQYQGSLHSR-LYQEIEIASVDAFQGREKDIIIMSCVRS---------NERQG-----IGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDR 875
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Fly
Match: Upf1 (gene:FBgn0030354 transcript:FBtr0073596) HSP 1 Score: 148.288 bits (373), Expect = 2.985e-35 Identity = 156/551 (28.31%), Postives = 230/551 (41.74%), Query Frame = 3
Query: 4044 NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMC--QEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKR 5681
+LN Q A++++ +LI GPPGTGKT+ I Y L+ VL C PSN +V+ + EK+ +T R C K +S + F +ALH +R +L + Q + + + + K + RN LK+A + +L + ++I T G+ L +K T I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + L+ QYRMHP + +FPS FY S ++G VC ED R LK D F P + F+ TQGQE+ GS S N E V+ + LK IK + I +IT Y Q L + Q L+S ++ +++V QG E D +I S VRS N G +GF+ D + NVALTRA+ G+ IVGN +L+ ++W ++ K R
Sbjct: 451 DLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGT-----VLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSF-----------------------LALHNQIRN--METNSELKKLQQLKDETGELSSADEKRY----RN----LKRAAENQL-LEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIR-PFRLEVQYRMHPELSQFPSNFFYEGSLQNG-------VC---------------------------AEDRR-----------------------LKLD--FPWPQPERPMFFLVTQGQEE------IAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQ----IGIITPYEGQRAYLVQYMQYQGSLHSR-LYQEIEIASVDAFQGREKDIIIMSCVRS---------NERQG-----IGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDR 875
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Fly
Match: CG7504 (gene:FBgn0035842 transcript:FBtr0273368) HSP 1 Score: 90.8929 bits (224), Expect = 1.060e-17 Identity = 93/310 (30.00%), Postives = 140/310 (45.16%), Query Frame = 3
Query: 4095 FTLIWGPPGTGKTLV---GCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKL---MKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLD--------------SEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEI----ILSTAAGSCKKLLESLKVTQI-ILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKE-------KYCIM------LDTQYRMHPSICEFPSIHFYND 4910
TLI GPPGTGK+ V C+ + D K +L C SN +V+ + L ++ R+ LLR + M H P++L+ S+ E LK H ++ Q EK N T Q+ +Q+ K+ I + L + ++E EI + + I+ T SC KL + I I+DE C+EP L P + L H+VL+GD +QL +V S+ A L+ S+F+R+ +S + Y +M L TQYRMHP IC +P+ +FY D
Sbjct: 936 LTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRK---ILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSH----YSRPFSLEAHFNKAKEQKLQRVSKENAEILK--KQHNDLKDEIQQLKEKTNLTSTYLLQQ---LQQKEKKLQLISNQLSPPLTQ--REEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPM--RFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYED 1229 HSP 2 Score: 53.9138 bits (128), Expect = 2.067e-6 Identity = 48/159 (30.19%), Postives = 70/159 (44.03%), Query Frame = 3
Query: 5220 GSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
N+S SN E V L T + K + K S + I+ Y+ Q Y L+++ +N TV QG E D +I S R+ + GF+T+ + NVALTR R+ L I GN L +MW+ +DD +KR + N
Sbjct: 1261 AQNKSISNNEEARFVAKLL-TEMDKHMPSKRFSYGL--ISPYQNQCYALSQVIPSHMNITP-------QTVDSYQGLEKDVIIISNART-----------------RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFN 1392
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Fly
Match: CG7504 (gene:FBgn0035842 transcript:FBtr0273367) HSP 1 Score: 90.5077 bits (223), Expect = 1.683e-17 Identity = 93/310 (30.00%), Postives = 140/310 (45.16%), Query Frame = 3
Query: 4095 FTLIWGPPGTGKTLV---GCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKL---MKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLD--------------SEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEI----ILSTAAGSCKKLLESLKVTQI-ILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKE-------KYCIM------LDTQYRMHPSICEFPSIHFYND 4910
TLI GPPGTGK+ V C+ + D K +L C SN +V+ + L ++ R+ LLR + M H P++L+ S+ E LK H ++ Q EK N T Q+ +Q+ K+ I + L + ++E EI + + I+ T SC KL + I I+DE C+EP L P + L H+VL+GD +QL +V S+ A L+ S+F+R+ +S + Y +M L TQYRMHP IC +P+ +FY D
Sbjct: 1195 LTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRK---ILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSH----YSRPFSLEAHFNKAKEQKLQRVSKENAEILK--KQHNDLKDEIQQLKEKTNLTSTYLLQQ---LQQKEKKLQLISNQLSPPLTQ--REEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPM--RFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYED 1488 HSP 2 Score: 53.5286 bits (127), Expect = 2.492e-6 Identity = 48/159 (30.19%), Postives = 70/159 (44.03%), Query Frame = 3
Query: 5220 GSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
N+S SN E V L T + K + K S + I+ Y+ Q Y L+++ +N TV QG E D +I S R+ + GF+T+ + NVALTR R+ L I GN L +MW+ +DD +KR + N
Sbjct: 1520 AQNKSISNNEEARFVAKLL-TEMDKHMPSKRFSYGL--ISPYQNQCYALSQVIPSHMNITP-------QTVDSYQGLEKDVIIISNART-----------------RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFN 1651
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Fly
Match: armi (gene:FBgn0041164 transcript:FBtr0100641) HSP 1 Score: 90.1225 bits (222), Expect = 1.997e-17 Identity = 106/389 (27.25%), Postives = 171/389 (43.96%), Query Frame = 3
Query: 4563 IGNYEIILSTAAGSCKKLLESLKV-------TQIILDECGMCSEPEALGPTMNKTELK-HLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCL---KKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKS--NELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
IG + I +ST C L L++ T ++ DE G C+EPE + P + T+ + +VL GD +QL+ IVTSR+A +IS ERL + + YR + FP YN + T + ++ +P Y L+ Y ++L I + E + + + +C+ +KDI P F G+ + +N S S N EV V + L + + +A Q I +IT Y+ Q KM + + + +P++ +V + QG E D ++ STVRS I +D + LGF+ + NVA++RAR + I GN HLL+V++ W+ I K N +
Sbjct: 830 IGTHRITIST----CTTLGNFLQLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLER---------SPYR--KDLQRFPESSGYNP-------LVLTKLLYNYRALPSIMS-------IYSRLF--YDDEL----IPVLSEKDSRESRLLSKLRCVFESEKDI-----PQAHGTFFYGIIGENRQ--------NNDSPSWFNPQEVREVFLMTIALYRANV---TADQ-IGIITPYQKQV----KMLRSMFIGTDVV-MPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFS-------LGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFCVKNNAY 1154
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Zebrafish
Match: si:dkey-97a13.6 (si:dkey-97a13.6 [Source:ZFIN;Acc:ZDB-GENE-070912-617]) HSP 1 Score: 261.536 bits (667), Expect = 1.657e-69 Identity = 240/852 (28.17%), Postives = 378/852 (44.37%), Query Frame = 3
Query: 3225 IRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFM----HPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWI-SRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNFPIKNLENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCD---AKPPP-------VLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEY----LKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQI-FRNYNICLKKALQKELEIGNYEIILST-AAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNL------NKMCQEILNSFGIFDLP--RVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNC 5687
+++Q + G +L ++ F +C+ H +P K F HP + + N+ EY + L +E + + I ++ + W SR + N E +I K W+ ++ R + + K ++ Q+ + K WV H V C EN G K + N + + M P K N+ + +E + + E ++ LK + + + R ++ + + L+ ++ LN Q ALE + N KFT+I GPPGTGKT+VG I YW++ LN + K P +LYCGPSN+SV+VVAE L+K FG KLLR+++ + ++P G+ L + E L+ I LH +R PY++++ ++ RI+ + Y L A ELE ++IIL T A + L ++L QI++DEC M +EP+ L P ++ K +VL+GDHKQLRPIV + + + SLFER IMLDTQYRMH IC+FPS +YND L T V E R + +N E G+R++ ++ILF +G+E +S G+ SK+N EV +K+ CI ++T R++ ++ N +I F+L V+T+ KSQGSE YVI S VRS P+ ++I+ P+ W+SK++GF+ DENQ NV +TRA+ GL I+GN +L+ + W+ + C
Sbjct: 1449 VQVQLTSERDRGYWAPTVQLFRLSSSFEICVEHTDNPIKCFSRIADHPSK------GSYSNVEEYVQIWRPLCEMESAATAVDDSDCVVIENVAITWDDSRLSGNFSLPEENI-------KKWA----IEFDLGRCLL---------CIRKRDLEQNQAEQSELDPKYFTWVAHA-VTTLCSDSPENS-GNKFKIINFNVKYASM--KIP-KFKRNETFTVEIIPKLLPDIRKESAVNNLKGANELVQNIALKHRIVNQSSNQDVPLYLLMREEAPAGLPQLNESQFKALEKALNGKFTIIQGPPGTGKTVVGAYIVYWFSQLNSRNLWRLKDPTDKDKREVILYCGPSNKSVDVVAEYLLK-FGEKL-KLLRVYSRQMEMQEYPYPGSNLQLSHKSRQERSKPELRAITLHHRIRMGHNPYSQRITDFD-------DRIKSDPYSLTDTDIEEYKKLLNDARLHELE--RHDIILCTCTAAASPNLKKTLSARQILIDECAMATEPQTLVPLVSFKPEK-VVLLGDHKQLRPIVKNNHVRRLGMTRSLFERYMDR----AIMLDTQYRMHEEICKFPSEAYYND-------MLKTVVRE------------------------------RTSVLNAETE-----GRRQS-----------------KRILFGDIRGEEIGLVVSTARGNENSKANFDEV----------------KKAVEICIQLVTVGRVRPEDIAILSPYNAQVAQIRERLSDFELKGFTVTTITKSQGSEWQYVILSIVRSCPS-DEIEPMPSREWLSKHIGFVGDENQINVGITRAQVGLCILGNQAVLNCSPAWQKLLKHYSGHGC 2177
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Zebrafish
Match: zgc:113057 (zgc:113057 [Source:ZFIN;Acc:ZDB-GENE-050508-3]) HSP 1 Score: 211.846 bits (538), Expect = 2.012e-54 Identity = 172/596 (28.86%), Postives = 283/596 (47.48%), Query Frame = 3
Query: 3222 LIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYL--LCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNF---PIKNL-ENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYE-TDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNK------------CDAKP---PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPY-----NLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCK-KLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESG 4925
++++Q G ++ G+ V +LL +N F +CL H +P F D + + +++ EY+ + L +I+ + + N+S + ++ ++W S E ++ G + K+ L+ F+ + R+ +++N ++ + WV H V KD N G+ N FK+ H + P + + ++ +E + I + E+++ LK + V K E + D +++ + K + LN+ QK A++ + FT+I GPPGTGKT+VG I + + NK D P P +LYCGPSN+SV++VAE+L+K G P LRI+ + +FP G+ +L E E L+DI L ++VRKP P++E++ + S NY LKKA Q E+E Y+++L T + + K +L E + QI++DEC M +EPEA P ++ + +VL+GDH+Q+RPIV K K + SLFER MLDTQYRMH IC FPS FY+ ++G
Sbjct: 771 VVQVQLGSEFKDGLPVPVVQLLSVNECFEICLEHSRNPTLCF--SDSVCIASKISYESYEEYQKIWTQLCQIDTAYNALEENNSVILEEVFINW---------SDEINLQGFFHLTKTQKTQWSLEFDLTNCFLC--IRLRRQKLDENLGKHIDRSAVSDLQGCLPFTWVAHA-VTTKSKKKDANTKGRIN--------FKITHRSMTYIPARIFNKGTKFTIEVIPKKIPYLLREQAVANLKRANNLVKSVATGKLELNDDADLRNISLYDVDKSLNLP-TLNMSQKKAVKEAMKKPFTVIQGPPGTGKTVVGIHIVFQFFKKNKDFMTSFKPNHTNPDGNPPKKPAILYCGPSNKSVDIVAEQLLKLSGVLKP--LRIYCDQMEMREFPYTGSELKLCRRSLRDEKPKEELRDITLMYLVRKPENPFSEEIKALEKNLS-------------VDQIDNYRKLLKKANQHEIE--KYDVVLCTCSSALKPELREVMDFRQILIDECAMATEPEAFIPLVSHNP-QQIVLLGDHQQIRPIVQCGHVKNKGMEKSLFERYM----DLANMLDTQYRMHAEICSFPSDEFYDGKLKTG 1321 HSP 2 Score: 101.293 bits (251), Expect = 9.779e-21 Identity = 67/180 (37.22%), Postives = 97/180 (53.89%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRS--LPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
+LF H +G+E + +S G+ S +N E E + L+K+ + + I ++T Y Q + KM E N + V TV+KSQGSE YVI STVRS +I+ P W+ K LGF+TD NQ NVA+TRA+ GL I+GNS LL ++W +D +++C N
Sbjct: 1339 MLFGHIEGKEVSLVVSTEKGNENSMANTEEAEQAVCVADLLIKQ---SGVSPEHIAILTPYNAQVSEI-KMTLEKKNVRNV----TVCTVMKSQGSEWPYVIVSTVRSCSTSDIQAYRVRPHKAWLGKRLGFVTDANQVNVAITRAQDGLCILGNSDLLRCCELWDRLLDHYYRKSCVVN 1510
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Zebrafish
Match: helz2 (helicase with zinc finger 2, transcriptional coactivator [Source:ZFIN;Acc:ZDB-GENE-120920-1]) HSP 1 Score: 209.534 bits (532), Expect = 1.542e-53 Identity = 175/608 (28.78%), Postives = 292/608 (48.03%), Query Frame = 3
Query: 3204 KIIDRQLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFM-HPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQ-TFIVN-KNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNFPIKNLENQ------QYLLEFMESPISTRIFERSLRKL-KTGTFSEELVIDRK----REFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWY----TILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLD-----SEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILST-AAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESG-----EVFLT 4940
+I + + +Q G + G+M +L +++P F +C+ H DP K F + R +Y +K+ Y++ + + +E + N S I D+ + W +NSN + + K WS L+ +F+ +R ++K +L Q T +++ + WV HG + +A + + ++ + ++++ F + H P+ N+ Q ++ LE + + E ++ L K + + + R+ R ++ +++ + +LN Q A+ + FTLI GPPGTGKT+VG I YW L +K +LYCGPSN+SV+VVA L+ R+ K LR+++ + +FP G L E L IALH ++RK G P++ ++ + + + E RK F +I LKKA + EL ++++IL T A S L E+L QII+DEC M +EPEA P + + +VL+GDHKQL+P+V VA+ ++ SLFER ++ +MLDTQYRM IC FPS FY ++G ++FLT
Sbjct: 1893 RIKQGEAVEVQLGASTARGLMTPSIQLFVVHPKFEICVEHVRDPVKCFSEYALSSSRSSYNLYKD---YQAIWRPMCEMESASSAVAENESILIVDVPLKW---ENSNPKRLQGFFLLPLDKKSQWSIDCDLR----NSFL-----CIRTRIQKQSSPFLESAQNTALMDIPSFTWVVHGVITEAEETESKESTNQEPK--SLRIDFLINH--MPMTNIPEQIFHERTRFTLELIPKLLPDVRKENAIDSLTKANQLVKNIAMGRRITSDRGCKIPNQNTGRFEINSYHPSGLSHLNNSQSKAIREALTNPFTLIQGPPGTGKTVVGVHILYWLHKNIQQLQASGSKKRAILYCGPSNKSVDVVAGHLLHL--RDHLKPLRVYSDQMEMLEFPYPGCNLKLSRNSKRGEKPNTELSSIALHHLIRKEGNPFSTQIRAFDMKVQRGDQLTDEERKLFREI-------LKKARKHEL--LHHDVILCTCTAASHPALAETLDFKQIIIDECAMATEPEAFIPLVAHKP-EQIVLLGDHKQLQPVVHCEVAERLGMSRSLFERYMEN----ALMLDTQYRMQEDICAFPSNEFYGGRLQTGIPAKSKLFLT 2465 HSP 2 Score: 112.079 bits (279), Expect = 5.947e-24 Identity = 69/178 (38.76%), Postives = 104/178 (58.43%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
I+F H +G+EK+ + G+ SK+N E E V + L + IK K I ++T Y Q ++ E L++ I D+ V+T+++SQGSE YVI STVRS P E I+ P WI K LGFITD +Q NV +TRA++GL I+GN +LL + +W+ ++ +++ C N
Sbjct: 2472 IVFGHVEGKEKSLVVRTEQGNENSKANMEEAEEVVRVAILLTEAGIKTKD----IAILTPYNAQVAKIS----ESLHNNHIRDIT-VNTIMRSQGSEWRYVIMSTVRSCPKSE-IETQPPKSWIMKRLGFITDPHQVNVGITRAQEGLCIIGNENLLRCSSLWRKLLNHYQEKGCVVN 2639
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Zebrafish
Match: upf1 (UPF1 RNA helicase and ATPase [Source:ZFIN;Acc:ZDB-GENE-040426-2836]) HSP 1 Score: 150.599 bits (379), Expect = 7.469e-36 Identity = 162/605 (26.78%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD LKK DF P + + F TQGQE EI+ + S +++ VE + +++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 400 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSSDEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------LKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TRLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 878
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Zebrafish
Match: upf1 (UPF1 RNA helicase and ATPase [Source:ZFIN;Acc:ZDB-GENE-040426-2836]) HSP 1 Score: 150.599 bits (379), Expect = 7.469e-36 Identity = 162/605 (26.78%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD LKK DF P + + F TQGQE EI+ + S +++ VE + +++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 400 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSSDEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------LKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TRLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 878
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Xenopus
Match: UPF1 (UPF1 regulator of nonsense transcripts homolog [Source:NCBI gene;Acc:100135270]) HSP 1 Score: 152.525 bits (384), Expect = 2.816e-36 Identity = 163/605 (26.94%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R E + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 413 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MESMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVE-------KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 891
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Xenopus
Match: UPF1 (UPF1 regulator of nonsense transcripts homolog [Source:NCBI gene;Acc:100135270]) HSP 1 Score: 151.754 bits (382), Expect = 3.696e-36 Identity = 163/605 (26.94%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R E + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 401 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MESMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVE-------KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 879
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Xenopus
Match: UPF1 (UPF1 regulator of nonsense transcripts homolog [Source:NCBI gene;Acc:100135270]) HSP 1 Score: 151.754 bits (382), Expect = 3.788e-36 Identity = 163/605 (26.94%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R E + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 406 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MESMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVE-------KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 884
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Xenopus
Match: UPF1 (UPF1 regulator of nonsense transcripts homolog [Source:NCBI gene;Acc:100135270]) HSP 1 Score: 151.754 bits (382), Expect = 4.180e-36 Identity = 163/605 (26.94%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R E + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 427 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MESMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVE-------KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 905
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Xenopus
Match: IGHMBP2 (immunoglobulin mu DNA binding protein 2 [Source:NCBI gene;Acc:100497063]) HSP 1 Score: 80.1073 bits (196), Expect = 3.173e-14 Identity = 90/300 (30.00%), Postives = 134/300 (44.67%), Query Frame = 3
Query: 4035 FECNLNLQQKLALENSANFK-FTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKL---LRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCK----KLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLY-KSKEKYCIMLDTQYRMHPSICEFPSIHFYN 4907
F +L+ QK A+ S N + +I GPPGTGKT I+ + + VL C PSN +V+ + E+L F +L R+ S + H A + +++ + +DI F K EK + Y+T K ++E R+E A + LK+A +IL+T G+ KLL +++DEC E ++ + K +L GDHKQL P + S A A L++SL ER+ K EK ML QYRMH SI ++ S Y
Sbjct: 183 FNLSLDDSQKEAVSFSLNQREVAVIHGPPGTGKTTT------VVEIILQAVKEGLKVLCCAPSNVAVDNLVERL-SVFKEKILRLGHPARLLES-LQHHSLDAVLARSD-NAQIVADIRRDIDQTFAKMKKLHGKQEK-SGYRTEIKALRKELKE-REEAAMVE-----TLKRA----------NVILATNTGASLDGPLKLLPEDYFDLVVIDECAQALEASCW---ISLLQAKKCILAGDHKQLPPTIISHKAAANGLSLSLMERVTEKYGEKVVKMLTVQYRMHQSIMQWASEALYG 453
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Mouse
Match: Helz2 (helicase with zinc finger 2, transcriptional coactivator [Source:MGI Symbol;Acc:MGI:2385169]) HSP 1 Score: 258.07 bits (658), Expect = 3.201e-68 Identity = 184/561 (32.80%), Postives = 278/561 (49.55%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNK----CDAKP--------PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPY-----NLDSEGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTM--NKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
LN Q A+ ++ +FT+I GPPGTGKT+VG I YW+ N+ D+ P P VLYCGPSN+SV+V+ L++ + K LR++ +FP G EG P + L+ I LH +R+ PYA ++ ++ +++E + + R Y L KA + ELE + +IL T + + K L+ L V QI++DE GM +EPE L P + +KT ++ +VL+GDHKQLRP+V S ++ ++ SLFER ++ IMLDTQYRMH IC FPS+ FY ++W+ DLRR L + G P ++F QG E+ +S G+ S++N EV +VV+ + + L + + K I V+T Y Q +++ L G+ + V+++ KSQGSE YVI STVR+ P D+D+ PT W+ K+LGF+ D +Q NVA+TRA++ L I+G+ LL +W +D
Sbjct: 2449 LNQSQDRAVRSALQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVLYCGPSNKSVDVLGGLLLRR--KTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDA-------QLREGKIFSKEDLRVYRRVLGKARKHELE--RHSVILCTCSCAASKSLKILNVRQILIDEAGMATEPETLIPLVCFSKT-VEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFERYHRD----AIMLDTQYRMHKDICSFPSVEFYGGK------------LKTWS-------------------------DLRR----------------------LPSILGHTGKPSCS-VIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQLTLDRTVDPKD----IAVLTPYNAQAAAISRG----LMQRGVTGVT-VTSITKSQGSEWRYVIVSTVRTCPR-SDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLD 2923
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Mouse
Match: Helz2 (helicase with zinc finger 2, transcriptional coactivator [Source:MGI Symbol;Acc:MGI:2385169]) HSP 1 Score: 258.07 bits (658), Expect = 3.217e-68 Identity = 184/561 (32.80%), Postives = 278/561 (49.55%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNK----CDAKP--------PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPY-----NLDSEGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTM--NKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
LN Q A+ ++ +FT+I GPPGTGKT+VG I YW+ N+ D+ P P VLYCGPSN+SV+V+ L++ + K LR++ +FP G EG P + L+ I LH +R+ PYA ++ ++ +++E + + R Y L KA + ELE + +IL T + + K L+ L V QI++DE GM +EPE L P + +KT ++ +VL+GDHKQLRP+V S ++ ++ SLFER ++ IMLDTQYRMH IC FPS+ FY ++W+ DLRR L + G P ++F QG E+ +S G+ S++N EV +VV+ + + L + + K I V+T Y Q +++ L G+ + V+++ KSQGSE YVI STVR+ P D+D+ PT W+ K+LGF+ D +Q NVA+TRA++ L I+G+ LL +W +D
Sbjct: 2449 LNQSQDRAVRSALQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVLYCGPSNKSVDVLGGLLLRR--KTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDA-------QLREGKIFSKEDLRVYRRVLGKARKHELE--RHSVILCTCSCAASKSLKILNVRQILIDEAGMATEPETLIPLVCFSKT-VEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFERYHRD----AIMLDTQYRMHKDICSFPSVEFYGGK------------LKTWS-------------------------DLRR----------------------LPSILGHTGKPSCS-VIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQLTLDRTVDPKD----IAVLTPYNAQAAAISRG----LMQRGVTGVT-VTSITKSQGSEWRYVIVSTVRTCPR-SDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLD 2923
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Mouse
Match: Helz2 (helicase with zinc finger 2, transcriptional coactivator [Source:MGI Symbol;Acc:MGI:2385169]) HSP 1 Score: 238.424 bits (607), Expect = 2.863e-62 Identity = 174/537 (32.40%), Postives = 263/537 (48.98%), Query Frame = 3
Query: 4119 GTGKTLVGCMIAYWYTILNK----CDAKP--------PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPY-----NLDSEGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTM--NKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
GTGKT+VG I YW+ N+ D+ P P VLYCGPSN+SV+V+ L++ + K LR++ +FP G EG P + L+ I LH +R+ PYA ++ ++ +++E + + R Y L KA + ELE + +IL T + + K L+ L V QI++DE GM +EPE L P + +KT ++ +VL+GDHKQLRP+V S ++ ++ SLFER ++ IMLDTQYRMH IC FPS+ FY ++W+ DLRR L + G P ++F QG E+ +S G+ S++N EV +VV+ + + L + + K I V+T Y Q +++ L G+ + V+++ KSQGSE YVI STVR+ P D+D+ PT W+ K+LGF+ D +Q NVA+TRA++ L I+G+ LL +W +D
Sbjct: 2429 GTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVLYCGPSNKSVDVLGGLLLRR--KTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDA-------QLREGKIFSKEDLRVYRRVLGKARKHELE--RHSVILCTCSCAASKSLKILNVRQILIDEAGMATEPETLIPLVCFSKT-VEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFERYHRD----AIMLDTQYRMHKDICSFPSVEFYGGK------------LKTWS-------------------------DLRR----------------------LPSILGHTGKPSCS-VIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQLTLDRTVDPKD----IAVLTPYNAQAAAISRG----LMQRGVTGVT-VTSITKSQGSEWRYVIVSTVRTCPR-SDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLD 2879
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Mouse
Match: Upf1 (UPF1 regulator of nonsense transcripts homolog (yeast) [Source:MGI Symbol;Acc:MGI:107995]) HSP 1 Score: 150.984 bits (380), Expect = 5.683e-36 Identity = 162/605 (26.78%), Postives = 244/605 (40.33%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W + K++
Sbjct: 426 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVVIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLSYYKEQKAL 904
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Mouse
Match: Upf1 (UPF1 regulator of nonsense transcripts homolog (yeast) [Source:MGI Symbol;Acc:MGI:107995]) HSP 1 Score: 150.599 bits (379), Expect = 7.607e-36 Identity = 162/605 (26.78%), Postives = 244/605 (40.33%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W + K++
Sbjct: 415 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVVIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLSYYKEQKAL 893
BLAST of Helicase with zinc finger domain 2 vs. UniProt/SwissProt
Match: sp|E9QAM5|HELZ2_MOUSE (Helicase with zinc finger domain 2 OS=Mus musculus OX=10090 GN=Helz2 PE=1 SV=1) HSP 1 Score: 258.07 bits (658), Expect = 2.239e-67 Identity = 184/561 (32.80%), Postives = 278/561 (49.55%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNK----CDAKP--------PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPY-----NLDSEGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTM--NKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
LN Q A+ ++ +FT+I GPPGTGKT+VG I YW+ N+ D+ P P VLYCGPSN+SV+V+ L++ + K LR++ +FP G EG P + L+ I LH +R+ PYA ++ ++ +++E + + R Y L KA + ELE + +IL T + + K L+ L V QI++DE GM +EPE L P + +KT ++ +VL+GDHKQLRP+V S ++ ++ SLFER ++ IMLDTQYRMH IC FPS+ FY ++W+ DLRR L + G P ++F QG E+ +S G+ S++N EV +VV+ + + L + + K I V+T Y Q +++ L G+ + V+++ KSQGSE YVI STVR+ P D+D+ PT W+ K+LGF+ D +Q NVA+TRA++ L I+G+ LL +W +D
Sbjct: 2449 LNQSQDRAVRSALQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVLYCGPSNKSVDVLGGLLLRR--KTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDA-------QLREGKIFSKEDLRVYRRVLGKARKHELE--RHSVILCTCSCAASKSLKILNVRQILIDEAGMATEPETLIPLVCFSKT-VEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFERYHRD----AIMLDTQYRMHKDICSFPSVEFYGGK------------LKTWS-------------------------DLRR----------------------LPSILGHTGKPSCS-VIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQLTLDRTVDPKD----IAVLTPYNAQAAAISRG----LMQRGVTGVT-VTSITKSQGSEWRYVIVSTVRTCPR-SDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLD 2923
BLAST of Helicase with zinc finger domain 2 vs. UniProt/SwissProt
Match: sp|Q9BYK8|HELZ2_HUMAN (Helicase with zinc finger domain 2 OS=Homo sapiens OX=9606 GN=HELZ2 PE=1 SV=6) HSP 1 Score: 176.407 bits (446), Expect = 1.289e-42 Identity = 112/307 (36.48%), Postives = 167/307 (54.40%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKP--PP----------VLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPC--AGAPYNLDS---EGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIF-RNYNICLKKAL--QKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFY 4904
LN Q +A+ + FT+I GPPGTGKT+VG I +W+ N+ +P PP +LYCGPSN+SV+V+A L++ R K LR+++ +FP G+ L EG P + L+ I LH +R+ PY+ ++ + T R + ++F R + KK L ++ E+ +E+IL T + + L+ L V QI++DE GM +EPE L P + + + +VL+GDHKQLRP+V + + L+ SLFER ++ MLDTQYRMH IC FPS+ FY
Sbjct: 2153 LNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLR---RMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDT------------RLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAH----MLDTQYRMHEGICAFPSVAFY 2440 HSP 2 Score: 110.153 bits (274), Expect = 1.939e-22 Identity = 65/169 (38.46%), Postives = 100/169 (59.17%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFID 5666
++F H QG E++ +S G+ SK+N EV EVV+ + L + ++ Q I V+T Y Q ++K L GI + VS++ KSQGSE YV+ STVR+ D+D+ PT W+ K+LGF+ D NQ NVA+TRA++GL ++G+ LL +W++ +D
Sbjct: 2467 VIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVE----PQDIAVLTPYNAQASEISKA----LRREGIAGVA-VSSITKSQGSEWRYVLVSTVRTCAK-SDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLD 2625
BLAST of Helicase with zinc finger domain 2 vs. UniProt/SwissProt
Match: sp|Q9EPU0|RENT1_MOUSE (Regulator of nonsense transcripts 1 OS=Mus musculus OX=10090 GN=Upf1 PE=1 SV=2) HSP 1 Score: 150.984 bits (380), Expect = 3.976e-35 Identity = 162/605 (26.78%), Postives = 244/605 (40.33%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W + K++
Sbjct: 426 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVVIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLSYYKEQKAL 904
BLAST of Helicase with zinc finger domain 2 vs. UniProt/SwissProt
Match: sp|Q92900|RENT1_HUMAN (Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2) HSP 1 Score: 150.599 bits (379), Expect = 5.125e-35 Identity = 162/605 (26.78%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + K++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 431 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------VKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TKLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 909
BLAST of Helicase with zinc finger domain 2 vs. UniProt/SwissProt
Match: sp|Q9HEH1|RENT1_NEUCR (Regulator of nonsense transcripts 1 homolog OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=2E4.130 PE=3 SV=1) HSP 1 Score: 150.214 bits (378), Expect = 6.731e-35 Identity = 152/550 (27.64%), Postives = 230/550 (41.82%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEI-GNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQ-EYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
LN Q A++ + +LI GPPGTGKT+ I Y ++ VL C PSN +V+ + E++ +T K++R+ A D E +L ALH VR ++L+ + ++ + ++ K F Q+ R Q E EI N +++ T G+ L +K +++DE +EPE + P + K +VL+GDHKQL P++ ++ A LN SLFERL K + I L QYRMHP + EFPS FY S ++G +T A E LR++ +DF P ++F G N+EIS S S N E V+ + K +K I VIT Y Q Y +N M + V++V QG E D+++ S VRS N + +GF++D + NVALTRA+ GL I+GN +L +++W + K + C
Sbjct: 456 LNASQIAAIKQVLSNPLSLIQGPPGTGKTVTSATIIYHLAKMSNSQ-----VLVCAPSNVAVDQLCERIHRT----GLKVVRLT-------------AKSREDVESSVSFL---ALHEQVRM--NTTNKELDGLVKLKTETGELSSQDEKRFKQLTR----------QAEREILQNADVVCCTCVGAGDPRLSKMKFRNVLIDESTQSAEPECMIPLV--LGCKQVVLVGDHKQLGPVIMNKKAAKAGLNQSLFERLVK-LQFTPIRLKVQYRMHPCLSEFPSNMFYEGSLQNG---VTAA------------------------------ERLRKD-------------------------VDFPWPVPETPMMFWSNLG---NEEISA---SGTSYLNRTEAANVEKIVTRFFKAGVKPAD----IGVITPYEGQRSYIVNTMQNTGTFKKESYREVEVASVDAFQGREKDFIVLSCVRSNEN--------------QGIGFLSDPRRLNVALTRAKYGLVIIGNPKVLCKHELWHHLLVHFKDKKCL 883
BLAST of Helicase with zinc finger domain 2 vs. TrEMBL
Match: V3ZVI7 (TPR_REGION domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_166880 PE=4 SV=1) HSP 1 Score: 346.28 bits (887), Expect = 4.284e-92 Identity = 261/834 (31.29%), Postives = 403/834 (48.32%), Query Frame = 3
Query: 3312 CLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKN---IYWVGHGRVCDACLLKDENVIGKKNRDY----NIQLTFKLMHSNFPIK-----NLENQQ-YLLEFMESPISTRIFERSLRK--LKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNL------NLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPP-------------VLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDS---EG-CPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIIL-STAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
CL H+ DP + + +++ ISEY + L +E Q++ +F I + V + ++ + G + S+ R +L ++ ++ K D++ CI+ + + WVGHG++ V K DY +++ F+L + K N+ Q + LE + + R + L+K +++ + +V++ + D HL ++ K E + N++Q A+E S FTLI GPPGTGKT G + Y +T +NK P VLYCGPSN+SV+VVA L+K G CPK+LR+++ +++ DFP G + EG CPE L ++ALH ++R+ G+PYA+K+ E+ F ++++ I + + + Y+ +++A ++EL + YE IL +T G ++ ++SLKV Q I+DECGMC+EPE L P + + LVLIGDHKQLRPI+ A L SLFER K I L+ QYRMHP IC FPS FY E+G L W K+ LR I GG++ I+F H +G+E+ + G +SKSN EV+ V L+R +++ E + I ++TQY+ Q + Q+ L + D V+TVV SQG E DYVI STVRSLP + I+ +PT GW S++LGF+ DENQ NVALTRARKGL I+GN ++L + W+ + +K+ C ++
Sbjct: 1605 CLEHKDDPVTCLTK-ESFESTKERKWMKISEYVKAWSALVEMEAAVQSVQGGDTFFIEHVPVRFTTQDS-----------GSFTLNHSFCSDRD---------VLGGIHISKDEEGKPITDFV-CIRKEVAQDSDNPFIWVGHGQM----------VYCSKREDYMESNELEVYFELHGTETCAKMRDVINIGTQDVFTLEIIPRSETDRRLKEVLKKNVIESNPLVKAIVLNSPIPMLDRDHLHLGKKIEKDLPKEELQILKLPGNNIKQCEAIEKSLTSAFTLIQGPPGTGKTYTGIKLVYLFTKINKIIKLEEPAKKGDKTMDGRNQVLYCGPSNKSVDVVARNLIKKLGNRCPKILRVYSKTVVYGDFPVPGKASPARATRREGQCPEDLHNVALHHIIRQKGKPYADKIREFDEKFKKESQGITK------MMIKTYHKLVRQAEEEELPL--YEAILCTTGVGGNRRTMKSLKVFQCIIDECGMCTEPETLLPIL-VAKPNQLVLIGDHKQLRPILMCSKAAKLGLEKSLFERYAKK----AIFLNIQYRMHPDICAFPSKQFYEGKLETGPSTL-------W----------------------EIKQPLR-----------IIGGKK---------------------IMFFHIEGEEEALTVHTDDGHERSKSNIQEVDKVVDLFRHMVR---NEDINPRSINIMTQYKSQ----MSLIQKKLKEYNFDDT--VNTVVASQGGEWDYVILSTVRSLP-LYKIEPSPTRGWTSEHLGFLADENQTNVALTRARKGLLIIGNKNMLKCDTTWRALLLHYEKQGCIQD 2322
BLAST of Helicase with zinc finger domain 2 vs. TrEMBL
Match: A0A210QEU8 (Helicase with zinc finger domain 2 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT08386 PE=4 SV=1) HSP 1 Score: 328.946 bits (842), Expect = 6.329e-87 Identity = 271/869 (31.19%), Postives = 424/869 (48.79%), Query Frame = 3
Query: 3219 QLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKN------KMDYLLCIQTFIVN------------KNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMH--SNFPIKNLENQQY----LLEFMESPISTRIFERSLRKLKTGT-FSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKP----PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCP-EYLKDIALHFVVRKPGQPYAEKLNEYQTIF-----------SQKTKRIQENRKEFAQIFRNYNICLKKALQKEL-EIGNYEIILSTAAGSCKKLL---ESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNC 5687
Q++ +Q G D + GI+ +LL + + ++CL H SDP KY + + F N+ Y ++ L R+E + ++S +I+D+ V + + GS + + ++ E R +K + +TF+ D +N +K+ D+L + +N + W+ HG+V +K+ N I N++ L+H S P + L++ + +E M +P+STR E +L+ LKT + ++ + + R + + K + N N +Q+ AL S + +FTLI GPPGTGKT G + Y +T LN +A+ V++CGPSN+SV+ VA+ ++ FG PKLLR+++ D+P + + + P E L+ ++LH ++RK +P+AEK+ EY F S + K +E KEF + Q EL EI +Y +I T A + + Q I++ECGMC+EPE++ + T+ K +VLIGDHKQLRP+V S+ A L SLFER Y K I L TQYRM+PSICEF S FY E+ W + +N + K D N P LF H +G+E+ +S G+ +S SN+ EV EVV Y +R ++K +++ + + I +++QYR Q + + + +E N F+ V+TVV SQG E DYVIFST RSLP+ + I+ NPT GW + LGFITD +Q NVAL+RARKGL I+GN HLL +K+W+ ++ ++ C
Sbjct: 1308 QILSVQVGADCNKGILEPSLQLLELTTNVKLCLQHTSDPVKYLAKY-AMMTADKSSFDNVESYLETWLPLIRMEAATLAVKADS-ITINDVPV----KLREDGGSFD--------LPTAFCEDRHIKFS--KTFMDDILNGENGEEKKDHSNVYQSSDFLCFKWPYEINDISSSFPREHPERTRIWLAHGQVESIRNIKEPNGI-------NVRF---LLHPTSPKPPQQLKSSRSKPLCSVEIMVNPVSTRRPESALQCLKTASQLAQAIALGRSLTPLYDARTTATLKTEVKVPGLKPN-NPEQEEALRASLSQQFTLIQGPPGTGKTYTGMKLIYLFTQLNMKEAQSGNALKQVVFCGPSNKSVDHVAKWTLRKFGVQAPKLLRMYSLTHESFDYPIPVKIHMVRKDQQPDEDLRGVSLHHLIRKAEKPHAEKIKEYDAYFRKFRDLVSIKNSDQAKEFKEKMKEFKSL----------KHQAELEEIRHYNVIFCTTAMTTNPTFICATKNSIGQCIIEECGMCTEPESMAAII-ATQAKQVVLIGDHKQLRPVVMSQHAARLGLEKSLFER-YADK---AIFLKTQYRMNPSICEFVSSQFYCGKLETA---------------------------------------------------WSTAWEEQNPLRLWK---DPNYP-----YLFCHVEGEEEYLSVSTEEGNEKSCSNQEEVREVVNY-FRCMVK---RDRVSPKNINIMSQYRAQCFAIKESLEE--NRLSNFN---VNTVVSSQGGEWDYVIFSTTRSLPDYK-IEPNPTIGWCKENLGFITDGHQINVALSRARKGLVIIGNKHLLRADKVWEQLLEHYERNGC 2065
BLAST of Helicase with zinc finger domain 2 vs. TrEMBL
Match: V4A037 (RNB domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_235246 PE=4 SV=1) HSP 1 Score: 327.02 bits (837), Expect = 4.560e-86 Identity = 267/849 (31.45%), Postives = 408/849 (48.06%), Query Frame = 3
Query: 3312 CLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKN---IYWVGHGRVCDACLLKDENVIGKKNRDY----NIQLTFKLMHSNFP------IKNLENQQ-YLLEFMESPISTRIFERSLRK--LKTGTFSEELVIDRKREFYETDKKHLDY-QLIKKKMTFE-------CNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPP-------------VLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAG--APYNLD-SEG-CPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIIL-STAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVK------YLYRT-----LLKKIIK-EKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
CL H+ DP + + + +++ ISEY + L +E Q++ +F I + V + ++ + G S+ R +L ++ ++ EK D++ CI+ + + WVGHG++ C K+ DY +++ F+L + + N+ Q + LE + + R + L+K +++ + +V++ D+ HLD + I+K + E N++Q A+E S FTLI GPPGTGKT G + Y +T +NK P VLYCGPSN+SV+VVA L+K G CPK++R++ ++F DFP G +P EG CPE L ++ALH ++R+ G+PYA+K+ E+ F +K + E++ + + Y+ +++A ++EL + YE IL +T G K+ +++LKV Q I+DECGMC+EPE L P + + LVLIGDHKQLRPI+ A L SLFER Y K I L+ QYRMHP IC FPS FY E+G L W K+ LR I GG++ I+F H +G+E+ + G +SKSN EV+ V Y Y+ L + +++ E + I ++TQY+ Q + K +E FD V+TVV SQG E DYVI STVRSLP + I+ PT GW ++ LGF+ DENQ NVALTRARKGL I+GN ++L + W+ + +K+ C ++
Sbjct: 1854 CLEHKDDPVT-CLTKESFESTKGRKWIQISEYVKAWSALVEMEAAVQSVQGGDTFFIEHVPVRFTTQDS-----------GSFTFNHSFCSDRD---------VLGSIHISKDEKEKPITDFV-CIRKEVAQDSDNPFIWVGHGQMVYCC----------KSEDYMESNELEVYFELHGTETSSSKMRDVINIGTQDVFTLEIIPRSETDRRLKDVLKKKVIESNPLVKAIVLNSSIPVL--DRDHLDLGKKIEKDLPKEELQILKLPGNNIKQHEAIEKSLTSAFTLIQGPPGTGKTYTGIKLVYLFTKINKIIKLEEPAKKGDKTIDGKNQVLYCGPSNKSVDVVARNLIKKLGNRCPKIVRVYGRTVVFCDFPVPGRASPSRAARREGQCPEDLHNVALHHIIRQKGKPYADKICEFDKKF-KKEIQFPESQGITKMMIKTYHKLVRQAEEEELPL--YEAILCTTGVGGNKRTMKNLKVFQCIIDECGMCTEPETLLPIL-VAKPNQLVLIGDHKQLRPILMCSKAAKLGLEKSLFER-YAEK---AIFLNIQYRMHPDICAFPSKQFYEGKLETGPSTL-------W----------------------EIKQPLR-----------IIGGKK---------------------IMFFHIEGEEEALTVHTDDGHERSKSNIQEVDKVMLSQRKLYDYQALPLVDLFRHMVRNEDINPRSINIMTQYKSQMSLIQKKIKEY-----NFD-NTVNTVVASQGGEWDYVILSTVRSLP-LYKIEPFPTRGWRTENLGFLADENQTNVALTRARKGLLIIGNKNVLKCDTTWRALLLHYEKQGCIQD 2592
BLAST of Helicase with zinc finger domain 2 vs. TrEMBL
Match: A0A210QEW8 (Helicase with zinc finger domain 2 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT08385 PE=4 SV=1) HSP 1 Score: 326.25 bits (835), Expect = 5.905e-86 Identity = 276/870 (31.72%), Postives = 426/870 (48.97%), Query Frame = 3
Query: 3219 QLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTH-DRTFILDPVNALREAVEKNKM----DYLLCIQTFIVNKNIY------------WVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSN--FPIKNLENQQY---LLEFMESPISTRIFERSLRKL-KTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNL------NLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKC---DAKP-PPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGC----PEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRN----YNICLKKALQKELEIGNYEIIL-STAAGSCKKLLESL--KVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF---GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNC 5687
Q++ +Q G + G++ P++L + +F +CL H SDP KY ++ + + +K+I+EY ++ L R+E G + + +++DL V + N +G+ + + E R ++ + FIL N E ++ K D+L + V+ IY W+ HG+V + I K + I++ F L S+ P + L +++ +E M P S R E +L L K ++++ + K DK HL + ++M E ++ N +Q A++ + +FTLI GPPGTGKT G + Y +T LN+ + P V+YCGPSN+SV++VA K G + P+++R++ S DFP G Y+ S E L+DIALH ++R+ G+P+A+++ E+ F Q + + A+ F+N YN L KA Q+EL+ +Y++I +TA + K + K+ Q I+DE GMC+EPE+L T+ T+ + +VLIGDHKQLRP+V + A L SLFER Y K + L TQYRM+P IC+F S FYND L TA +W K + +Y ++ + H+ +E+ T E+ E SC SN+ EVE V ++R +LK E + I +I+QY N C I + G + V+TVV SQG E DYVIFST RSLP+ + I+ PT GW + LGFITDE+Q +VAL+RARKGL I+GN +LL +K+WK +D +KR C
Sbjct: 1454 QILLVQIGAEPQKGVLVPTPQILELTNNFILCLQHTSDPVKYLAKY-ATRKAHTENYKSIAEYLEVWLSLIRMEAA-TMAGHDDAITVNDLPV----KLNEKDGT--------FSMTMDFCEDRNIEFSSMSMEFILHG-NEDDENSDETKYVPSSDFLCLKCRYEVDDVIYKGLKGSPGEQRIWLAHGQV---------DKIKKMKKMGRIEVHFLLHPSSQSLPPQLLNSERKPKCSVEIMAKPESNRRTEAALLCLDKANGLAQKIAMRFK--IPALDKNHL---ALARRMEAEVDVVGLARNNTKQYQAIQQALTNRFTLIQGPPGTGKTFTGMKLLYLFTKLNRVWHQEGNPLKQVVYCGPSNKSVDLVARWTKKKLGEHAPRMVRMYGSSHECMDFPIPGKLYSHKSRRAKNRPDEDLQDIALHRLIRQEGKPHADEILEFDKYFQQFHNCPSISDHDLAETFKNKLKDYNSLLSKAGQEELQ--HYDVIFCTTAMTTNPKFIRGTKDKIFQCIIDENGMCTEPESLA-TIIATKAEQVVLIGDHKQLRPVVMCQHAARLGLEKSLFER-YSEK---AVFLSTQYRMNPRICDFVSAEFYNDK-------LDTAPSRAW------KEETPLSIWKYPDVPHIF------CHVEGEEEYL--------------------------------TVSTEEGNEHSC--------SNKAEVEKVMQVFRRMLK---TEGVNPRYINIISQY-------NAQCHAIKTALVDSGYINC-NVNTVVASQGGEWDYVIFSTTRSLPDYK-IEPIPTLGWCKQNLGFITDEHQIDVALSRARKGLVIIGNENLLQCHKVWKHLLDHYRKREC 2216
BLAST of Helicase with zinc finger domain 2 vs. TrEMBL
Match: C3XYY1 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_90929 PE=4 SV=1) HSP 1 Score: 320.472 bits (820), Expect = 6.865e-84 Identity = 248/872 (28.44%), Postives = 403/872 (46.22%), Query Frame = 3
Query: 3219 QLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVN--------------ALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHS--NFPIKNLENQQYL---LEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKC-------DAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLK------DIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGP----------TMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKK-IIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVS--TVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKND 5699
Q++++Q D G+++ +L + P VCL HR D F P N R++++ Y+++++ + +E H + +N S +H + W +Q+ G E G + + + + + R + L VN +R A+ + + +T + + WVGH CL+ V +D +I + KL FP L + + +E + + R E ++R L + + + K L ++ + + LN Q+LA++ + + FTLI GPPGTGKT+ G IAY+ +NK PP VLYCGPSN++V+VV + K G K++R+++ I +FP P + + + K D++LH ++RKP P+AE + ++++F + EN ++N+ I KA EL + + TAA S K+ + + Q I+DECGMC+EPE+ P +M K ++LIGDH+QLRPIV + ++ L+ SLF+R Y K ML QYRMH +IC FPS FY N +++ + R D W G R F H G+E+ Q ++ G+ S+SNE+E ++ + L+++ IK ++ +++++QYR Q +NK + RV +VV SQGSE DYVIFSTVRSLP+ E I++NP+P W+ KYLGFI D+NQ NVA+TRA++GL ++GN +LL V+ +W I +++ C N+
Sbjct: 3002 QVVKVQLTGDIQKGLLSPCIQLFNLTPKMDVCLDHRRDAVTRFAVPATQSVRNMTRYRSVQMYQNRWLPIMAVEAAHCAMENNESVFVHGTFISWEKQQHQTTG--EVAYIGKITLSQKFCKDRCIHFDQGNQNKLTSVNDTGKHFDYICVRYTGVRAAMTHDGRFNIAADKTEEKHPLVCWVGH------CLVM-PGVEYTTRQDGDITVPIKLHQHLMAFPDTLLHHGTSIPATIEIITKTLPDRRMENAVRWLSGSSHLVQQIATGKN--ITARGNPLANEITIEPLPAFFPLNQVQELAVKQAISQPFTLIQGPPGTGKTVTGVHIAYFLAEMNKRIQSVSGEGMYPPQVLYCGPSNKAVDVVTGYMKKIKG--GLKIVRMYSEMIEREEFPIPNEPVHPNKCKSEKESKITNEHDDVSLHHLIRKPSNPHAETIKAFESLFKDPNYTVTEND---ITTYKNHII---KAKIHELRQKHVILCTCTAAAS-PKMGMATNIEQCIVDECGMCTEPESFVPIVGAPVERNGSMTFHNPKQVILIGDHQQLRPIVLEKTSQQLGLDTSLFQR-YAWK---ATMLTIQYRMHEAICSFPSRMFYE------------------------------------NKLRTHRTVIERPRHPALDRLWPGGDNRPT--------------------AFCHVVGKEEVQTVATAEGNQMSRSNEMEADMAVKMAICLVREHGIKPEN----VILLSQYRAQCALINKKLSSERKRLNDERVERVGVNSVVSSQGSEWDYVIFSTVRSLPSYE-IEQNPSPSWLRKYLGFIMDQNQVNVAITRAKRGLCVIGNKNLLRVHTLWNKLIIHYEEQKCLVNN 3788 HSP 2 Score: 70.4774 bits (171), Expect = 6.196e-8 Identity = 83/367 (22.62%), Postives = 154/367 (41.96%), Query Frame = 3
Query: 810 GNDEKSD-------KKSDTKIPY--YVPFQFEKLSKN--DKTFNCKLFLEDAHSGYGEILEGSKKGNKIYLHNRKNCGQAFCGDIVKILVFQNSADKITKPNKKLKKFREENKQLTGRVISVISSEVKPINKIFLCHLLNGTTNLMTPICNTIPVIYVDNKHAVEATKKHCNNLKEMNVVGIQNIIQKTIPVVISDSFANKSFVTLKDLHDNLTTTVNSVYYVDCYTCEYIFLVLYRNWDNCHRFPDGEVVGIYTPDVNFENTLNIIKITCDVP--VIGIDEEQSFHXXXXXXXXXXXXXXXXXXSDR--TVFSFKQPNKEFNEMAFSYKNLTDNTFEVGVHVTNVCKYIQQNEFLDTLSVNRFFTF 1865
G DE D ++SD + Y Y P + E L ++ D+ C+L ++ ++ YGE++ + + I +++RKN G + D V + + +N+ +++ + F+ + G+V+ +I S V + F+C + N N+M PI P L N +G +N ++ V + + F T +D+ D Y + +F+V + W +P G V + TPD + ++ I+ +VP G EE + + + + + K R TVF+ P + AFS + D T+ VG+H+ +V ++ LD + R T
Sbjct: 2184 GEDEPYDPTQLEVQEESDNQCFYTNYSPEELENLLRDHPDRYRRCRLVVKGTYTAYGEVIGADE--DDILINSRKNRGLGWANDEVVVEILKNT-------DQESEVFKTSSDIRRGKVVGIIRSAVSLHLRKFVCVVDNNNPNVMVPINTDAP------------------KLVAYNYLGKENRRPNSVRVYSYMTDGSFKFKTYEDIDPR-----------DPY--KKLFVVRFLKWTPRFVYPLGLVTDVITPDSTLDTSMEILNNRFNVPSKYKGKVEEDVNRRYFVDWQIPQKERNQRKDLSRTHTVFTVDPPESMDLDDAFSIERNLDGTYTVGIHIADVSYFVPVGSDLDKEAKERSTTL 2510
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Cavefish
Match: helz2 (helicase with zinc finger domain 2-like [Source:NCBI gene;Acc:103025927]) HSP 1 Score: 174.481 bits (441), Expect = 6.316e-43 Identity = 119/308 (38.64%), Postives = 170/308 (55.19%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNK----C------DAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDS-----EGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESG 4925
LN Q A+ + N +FTLI GPPGTGKT+VG I YW+ N+ C D K +LYCGPSN+SV+VVA +L+K + K LR+++ + +FP G+ + E E L+ I LH +R PY +++ E+ +RI+ ++ + + Y CLKKA + EL N I+ + A S L ++L QII+DEC M +EPEA P + K +VL+GDHKQL+P+V + + + + ISLFER Y +K +MLDTQYRM IC FPS FY ++G
Sbjct: 2324 LNNSQCKAIREAMNNEFTLIQGPPGTGKTVVGVHIVYWFFKQNQKLPPCQKLGDEDLKKRCILYCGPSNKSVDVVAGQLLKLKEKL--KPLRVYSDQVEIMEFPYPGSNLKISRHCQRVEKPNEALRSITLHHKIRMTSNPYHKQILEFD-------ERIKADQYLTDEEIKCYKDCLKKARKHELLQHNV-ILCTCTAASHPVLADALNFQQIIIDECAMATEPEAFIPLVTHKP-KQIVLLGDHKQLQPVVHTDLLQRLGMRISLFER-YTNK---ALMLDTQYRMQKDICAFPSEEFYRGKLKTG 2616 HSP 2 Score: 114.005 bits (284), Expect = 1.340e-24 Identity = 67/176 (38.07%), Postives = 103/176 (58.52%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
ILF H +G+E + +S G+ SK N E + V + R L+K IK K I ++T Y Q ++ +LN+ GI ++ V+T++KSQGSE YVI STVRS P + +I+ PT W+ K LGF+ D +Q NV +TRA++GL ++GN +LL +W+ + + + C
Sbjct: 2634 ILFGHVEGKELSLVVSTERGNENSKGNIEEAKAVVRIARNLIKSGIKPKE----IAILTPYNAQVNEIST----VLNTNGIRNVT-VNTIMKSQGSEWKYVILSTVRSFP-MSEIEIQPTKAWLKKRLGFVMDPHQVNVGITRAQEGLCLIGNKNLLRCCYLWRKLLTHYEDKGCL 2799
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Cavefish
Match: upf1 (UPF1 RNA helicase and ATPase [Source:NCBI gene;Acc:103031971]) HSP 1 Score: 149.443 bits (376), Expect = 1.140e-35 Identity = 161/605 (26.61%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + +++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRAR G+ IVGN LS +W ++ K++
Sbjct: 400 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNG-----PVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSMPELQ-----KLQQLKDETGELSSSDEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------IKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TRLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVL 878
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Cavefish
Match: ENSAMXT00000036328.1 (pep primary_assembly:Astyanax_mexicanus-2.0:5:1303467:1306311:1 gene:ENSAMXG00000040064.1 transcript:ENSAMXT00000036328.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 111.694 bits (278), Expect = 6.678e-27 Identity = 67/178 (37.64%), Postives = 100/178 (56.18%), Query Frame = 3
Query: 5163 ILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
ILF H QG+E + +S TG+ S SN+LE E + L+++ + I ++T Y Q + ++ ++ V T++KSQGSE YVI STVRS P + +I + G + K LGFITD NQ NVA+TRA+ GL I+GN LL +++WK + +++NC N
Sbjct: 38 ILFAHVQGEEVSLIVSTPTGNENSVSNKLEAEQAVRVADLLVRQ---SGVKPEDIAILTPYNAQVCTIKQLLEKKSEKREDMQGVTVCTIMKSQGSEWPYVIVSTVRSCP-LSEIKSSKNKGRMGKKLGFITDPNQVNVAITRAQDGLCILGNRQLLESSQLWKKLVSHYERQNCVVN 211
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Cavefish
Match: ENSAMXT00000056754.1 (pep primary_assembly:Astyanax_mexicanus-2.0:5:1290788:1298077:1 gene:ENSAMXG00000031111.1 transcript:ENSAMXT00000056754.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 97.0561 bits (240), Expect = 2.975e-20 Identity = 103/414 (24.88%), Postives = 184/414 (44.44%), Query Frame = 3
Query: 3219 QLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHP--DELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFIL---DPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNFPIKNLE----NQQYLLEFMESPISTRIFERSLRKLKTGT-FSEELVIDR-KREFYETDKKHL---DYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAK-----------PPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKD 4385
+++++Q G D + +LL INP F VCL H +P F D K + +++ EY+ + L +++ + + N+S + D+++ W ++ N E ++ G + ++ + L+ F+ + +E V++ K I WV HG + K+E+ + +NI++ F++ H + E ++ +E + I + E ++ K+K + + I E ++D HL D+Q + LN Q A++ + FT+I GPPGTGKT+VG I Y + + NK K +LYCGPSN++V++VAE+LM R K LRI+ + +FP G+ L C + L+D
Sbjct: 60 EVLQVQVGTDIIDRMTTPTVKLLYINPFFEVCLEHARNPTMCFSRDVCDSSKSV----YQDYKEYQKIWRRLCQMDTAYNAVEENNSVILQDVEITWTTQDKKN----EENLKGFFQMTQTQKKEWHLEFDLTNCFLCIRWKGQHLGKEEVKQKKHHNGSGFPDLEDPLPITWVAHGVAFKS--KKEEDEEENNKQSHNIKIQFQINHQSMTANPKEIFDTGTKFTVEVIPKKIPYMLRENAVAKIKHANDLVKSIAIGNISNEPLKSD--HLPSEDHQTLTLP-----PLNKSQNRAVQKALQNPFTVIQGPPGTGKTVVGLHITYQFYLKNKTCQKHMPKKQKEEPKKRAILYCGPSNKAVDIVAEQLMNL--RGVLKPLRIYCDQMEMREFPYPGSDLKL----CRKSLRD 450
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Cavefish
Match: mov10b.1 (Moloney leukemia virus 10b, tandem duplicate 1 [Source:NCBI gene;Acc:556024]) HSP 1 Score: 94.7449 bits (234), Expect = 7.050e-19 Identity = 108/386 (27.98%), Postives = 166/386 (43.01%), Query Frame = 3
Query: 4560 EIGNYEIILSTAAGSCKKLLESLKV---TQIILDECGMCSEPEALG--PTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKG------GQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEV-EVVKYLYRTLLKKIIKE---KSASQCILVITQYRLQEYNLNK---MCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFI 5663
E+ +Y+I+++TA + + + L T I +DE G E EA+ + + E LVL GD KQL PI+ S +A L +SL ERL Y + GE TG FN L +Y+ R+ + I +E + G + + C + + G P ++F QG+++ + S+ S N E+ +V+ YL + LL K+ K + + I +IT YR Q L K MC + L F D +V +V + QG E +I STVRS +ID + +GF+ +E +FNVA+TRA+ L +VGN +LS + W FI
Sbjct: 486 ELMDYKILVTTAYTAGRLVTGGLPAGHFTHIFVDEAGHAVESEAIIGIAGLLRAETGQLVLAGDPKQLGPILRSPIAIQYGLGLSLLERLMTKNPLY---------------------------QKGE-----------TG---------FNPRYVTKLLQNYRS--HRSILKIPNEMFYDGELQARADEYSTSLYCNWEHLPKRGFP----LIFHGVQGKDERE------SSSPSFFNTTEITKVIDYLKKLLLTTQGKKGIAKISPKDIGIITPYRKQVEKLRKAIRMCDKELKVFKGIDELKVGSVEEFQGQERRVIIVSTVRSSGEYINIDTDFN-------IGFLNNEKRFNVAMTRAKSLLIVVGNPIILSSDSTWSRFI 805
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008666.1 (pep scaffold:Pmarinus_7.0:GL478401:184246:194592:-1 gene:ENSPMAG00000007841.1 transcript:ENSPMAT00000008666.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 183.726 bits (465), Expect = 1.032e-49 Identity = 112/315 (35.56%), Postives = 173/315 (54.92%), Query Frame = 3
Query: 4044 NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNK-------CDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAP--YNLDSEGCPEY---LKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQ-ENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKK-LLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDS----RESGEVF 4934
LN+ Q ++ S FT+I GPPGTGKT+VG + W+ + K DAK LYCGPSN+SV+VVAE L+K K LR++ +FP G L S+ P +K I LH+ +R+ PYA+++ +Y +++ K + E E+ ++ ++ + +E+ +++++T + + LL++L ++DEC MC+EPE L P + ++ +VL+GDHKQLRP V +R A + S+FER K IMLDTQYRMHP ICEFP+ FY+++ + + EVF
Sbjct: 1 QLNIMQTTVIKQSLTSAFTVIQGPPGTGKTVVGIHLVKWFHEVIKTLRENLQADAKHICSLYCGPSNKSVDVVAEHLVKIEDL---KPLRVYGQQTEEEEFPIPGETDVIFLRSKKVPRVNLTIKSITLHYKIREDTNPYAQQIRKYDDGQTEEVKDLTLEEIIEYKKLIKDAKV---------IELKKSDVVITTCSTAATVILLKNLDPRVCLVDECAMCTEPECLIPLTSYKDIAQVVLLGDHKQLRPFVLNRTAAKLGMEKSMFERYAKR----AIMLDTQYRMHPDICEFPAKQFYSETNKTLKTAKEVF 299 HSP 2 Score: 114.005 bits (284), Expect = 2.448e-26 Identity = 73/178 (41.01%), Postives = 100/178 (56.18%), Query Frame = 3
Query: 5166 LFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKK-IIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVS--TVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
LF H G+E +S GS SK+N+ EVE V L L+KK I EK I ++T Y N EI + + +V+ T+ KSQGSE YV+ STVRS ++++ NP+ GW LGFI DENQ NVALTRA++GL I+GN LL + +WK I+ +++C
Sbjct: 317 LFGHVVGKEVTLVVSTEEGSENSKANKAEVEQVVRLVSELIKKGSIAEKD----IAILTPY-------NAQANEIQKALEKEHIKKVTATTITKSQGSEWRYVLLSTVRSC-SLDEFKANPSRGWQISRLGFIIDENQVNVALTRAKEGLCIIGNQDLLMCSDLWKELIESYHEKDCL 482
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008661.1 (pep scaffold:Pmarinus_7.0:GL478401:184160:191851:-1 gene:ENSPMAG00000007841.1 transcript:ENSPMAT00000008661.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 126.331 bits (316), Expect = 1.113e-30 Identity = 79/228 (34.65%), Postives = 125/228 (54.82%), Query Frame = 3
Query: 4281 KLLRIFNSDIMFHDFPCAGAP--YNLDSEGCPEY---LKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILST-AAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDS----RESGEVF 4934
K LR++ +FP G L S+ P +K I LH+ +R+ PYA+++ +Y +RI+ +K + + Y +K A K +E+ +++++T + + LL++L ++DEC MC+EPE L P + ++ +VL+GDHKQLRP V +R A + S+FER K IMLDTQYRMHP ICEFP+ FY+++ + + EVF
Sbjct: 25 KPLRVYGQQTEEEEFPIPGETDVIFLRSKKVPRVNLTIKSITLHYKIREDTNPYAQQIRKYD-------ERIRILKKFRSMQSKKYKKLIKDA--KVIELKKSDVVITTCSTAATVILLKNLDPRVCLVDECAMCTEPECLIPLTSYKDIAQVVLLGDHKQLRPFVLNRTAAKLGMEKSMFERYAKR----AIMLDTQYRMHPDICEFPAKQFYSETNKTLKTAKEVF 239 HSP 2 Score: 115.546 bits (288), Expect = 4.905e-27 Identity = 72/179 (40.22%), Postives = 100/179 (55.87%), Query Frame = 3
Query: 5166 LFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVS--TVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKN 5696
LF H G+E +S GS SK+N+ EVE V L L+KK A + I ++T Y N EI + + +V+ T+ KSQGSE YV+ STVRS ++++ NP+ GW LGFI DENQ NVALTRA++GL I+GN LL + +WK I+ +++C N
Sbjct: 257 LFGHVVGKEVTLVVSTEEGSENSKANKAEVEQVVRLVSELIKK---GSIAEKDIAILTPY-------NAQANEIQKALEKEHIKKVTATTITKSQGSEWRYVLLSTVRSC-SLDEFKANPSRGWQISRLGFIIDENQVNVALTRAKEGLCIIGNQDLLMCSDLWKELIESYHEKDCLGN 424
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Sea Lamprey
Match: upf1 (UPF1 RNA helicase and ATPase [Source:ZFIN;Acc:ZDB-GENE-040426-2836]) HSP 1 Score: 117.472 bits (293), Expect = 1.761e-26 Identity = 92/297 (30.98%), Postives = 136/297 (45.79%), Query Frame = 3
Query: 4044 NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESG 4925
+LN Q A++ +LI GPPGTGKT+ I Y N PVL C PSN +V+ + EK+ +T R C K +S + F +ALH +R + L E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + PT+ K L+L+GDH QL P+V + A L SLFERL + I L QYRMHP++ FPS FY S ++G
Sbjct: 458 DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLAKQNSG-----PVLVCAPSNIAVDQLTEKIHRTGLKVVRLCAKSREAIDSPVSF-----------------------LALHNQIRN-----MDSLPELQ-----KLQQLKDETGELSSADEKRYRALKRNAEREL-LMNADVICCTCVGAGDPRLAKMQYRSILIDESTQATEPECMVPTV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLCQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQNG 712 HSP 2 Score: 60.8474 bits (146), Expect = 2.972e-9 Identity = 58/189 (30.69%), Postives = 85/189 (44.97%), Query Frame = 3
Query: 5118 LKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFG-IFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKR 5681
+KK DF + + F TQGQE EI+ S S N E V+ + LLK K I +IT Y Q L + Q + ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRA+ G+ IVGN LS +W ++ K++
Sbjct: 719 VKKGFDFTWTQPDKPMFFYVTQGQE---EIAS---SGTSYLNRTEASNVEKITTRLLKAGAKPDQ----IGIITPYEGQRSYLVQYMQFSGSLHAKLYQEVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRAKYGVIIVGNPKALSKQPLWNHLLNYYKEQ 883
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Sea Lamprey
Match: ighmbp2 (immunoglobulin mu DNA binding protein 2 [Source:ZFIN;Acc:ZDB-GENE-050419-258]) HSP 1 Score: 76.2554 bits (186), Expect = 4.517e-14 Identity = 75/293 (25.60%), Postives = 121/293 (41.30%), Query Frame = 3
Query: 4083 ANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCP--KLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDI-----ALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNY-NICLKKALQKELEIGNYEIILSTA----AGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCI-MLDTQYRMHPSICEFPSIHFYNDSRES 4922
A + +I GPPGTGKT I+ + + VL C PSN +V+ + E+L C ++LR+ + + L ++D+ +H +R G E+ R+Q + + R + ++ LQ + ++IL+T AG KLL ++DECG E + P + + VL GDH+QL P + S+ A L +SL ERL + + ML QYRM+ +I ++ S H Y E+
Sbjct: 208 AQREVAIIHGPPGTGKT------TTVVEIIQQTVRRGEKVLACAPSNVAVDNLVERLA------CAGVRVLRLGHPARLLDSVRSRCLDAVLARGDDAGIVRDVRSDMDKVHAKLRN-GSERGER------------ARLQAEMRSLRKELREREDTAMRNILQ------SADVILATTTGAWAGGPLKLLPPAHFAVAVVDECGQAVEAASWLPLL---QAPRCVLAGDHRQLPPTIVSQRAAEGGLAVSLMERLVERLGSSAVRMLTVQYRMNAAIMDWASQHVYQGKLEA 466
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000979.1 (pep scaffold:Pmarinus_7.0:GL478231:754:10442:1 gene:ENSPMAG00000000889.1 transcript:ENSPMAT00000000979.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 62.3882 bits (150), Expect = 1.086e-9 Identity = 49/162 (30.25%), Postives = 78/162 (48.15%), Query Frame = 3
Query: 5193 KNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVN-KMWKTFIDDLK 5675
++ E+ ++S+ N E V L R L I++ +Q I V+T Y Q L +M F RV V K QG E+D V+ S VRS + + P GF+ +EN+ VAL+RA++GL++VGN+ +L+ +W + L+
Sbjct: 180 EHSELEEEVADSRSRHNRHEARFVVALCRYL---ILQGYRPAQ-ITVLTMYAGQLLALRRM-----MPRDPFQGVRVCVVDKYQGEENDIVLLSLVRS-----NAEGRP---------GFLRNENRACVALSRAKRGLYVVGNAAMLAATVPLWARLLRALR 318 HSP 2 Score: 55.4546 bits (132), Expect = 1.453e-7 Identity = 37/119 (31.09%), Postives = 59/119 (49.58%), Query Frame = 3
Query: 4581 ILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTS-RVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVF 4934
+ +T A + L+ ++ +I++E E + T +HL+LIGDH+QLRP T +A L +SLFERL ++ + + L Q+RM P I H Y + R+ V
Sbjct: 49 MTTTGAAKYRHTLQKIRPRIVIVEEAAEVLEAHIV--TTLSPGCQHLILIGDHQQLRPSATVYELATHFHLEVSLFERLVRNGLPF-VRLQYQHRMRPEIARLLVPHIYTELRDHPSVL 164
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Yeast
Match: NAM7 (ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress [Source:SGD;Acc:S000004685]) HSP 1 Score: 137.117 bits (344), Expect = 8.040e-33 Identity = 142/562 (25.27%), Postives = 227/562 (40.39%), Query Frame = 3
Query: 4041 CNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKL----NEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGN-YEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQE-YNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILE 5708
LN Q A+ + +LI GPPGTGKT+ I Y + ++K +L C PSN +V+ +A KL + G +L D+ + ++ALH +V + + + L +E + + TKR F ++ R + E EI N +++ T G+ K L++ K +++DE SEPE L P + K ++L+GDH+QL P++ R A L SLFERL S I L+ QYRM+P + EFPS FY S ++G V +P++K G+ + FW G +++I NG +I + ++C ++ K+ ++ + I VIT Y Q Y L M ++ V++V QG E DY+I S VR+ + +GF+ D + NV LTRA+ GL I+GN L+ N +W + +++ C L+
Sbjct: 407 AQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKIHK-----DRILVCAPSNVAVDHLAAKL-RDLGLKVVRLTAKSREDV-------------------ESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKR-------FVKLVR----------KTEAEILNKADVVCCTCVGAGDKRLDT-KFRTVLIDESTQASEPECLIPIVKGA--KQVILVGDHQQLGPVILERKAADAGLKQSLFERLI-SLGHVPIRLEVQYRMNPYLSEFPSNMFYEGSLQNG-------VTIEQRTVPNSKFPWPIRGIPMM--------------------FWANYG---------REEISANGTSFLNRI-----------EAMNC---------------------ERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQ--------------QAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGTLD 840
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Yeast
Match: HCS1 (Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities [Source:SGD;Acc:S000001500]) HSP 1 Score: 123.25 bits (308), Expect = 7.048e-29 Identity = 158/555 (28.47%), Postives = 221/555 (39.82%), Query Frame = 3
Query: 4044 NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENR--KEFAQIFRNYNICLKKALQKELE----------IGNYEIILSTAAGSCKKLLESLK--------VTQIILDECGMCSEPEALGPTM-NKTELKHLVLIGDHKQLRPIVTSRVAK--AKQLNISLFERLYK--SKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLL 5633
NLN QK A+ + N T+I GPPGTGKT + I N + +L CGPSN SV+ + E+L N LLRI G P L D R ++K + I + K IQEN+ K + Q N+N K L+K+L+ I I+++T GS + L SL +I+DE EP+ P + ++ + LVL GD+KQL P + + K L +LF+R+ K K L+ QYRM+ I EFPS YN G++ V N L V+ PS +D D P +++ TQG E QE + SK NE E+ +VK L + E S I VI+ Y Q +L K+ + L I +STV QG E D +I S VRS E +GF+ +E + NVA+TR R+ L +VGN +L
Sbjct: 207 NLNDSQKTAINFAINNDLTIIHGPPGTGKTFTLIELIQQLLIKNPEER----ILICGPSNISVDTILERLTPLVPNNL--LLRI----------------------GHPARLLDSN----KRHSLDILSKKNTIVKDISQEIDKLIQENKKLKNYKQRKENWNEI--KLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNFQLFDTLIIDEVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRIIKIFPKRDMVKFLNVQYRMNQKIMEFPSHSMYN-----GKLLADATVA-----------NRLLIDLPTVDATPSEDDD------------------------------DTKIP-----LIWYDTQGDEF-QETADEATILGSKYNEGEIAIVKEHIENLRSFNVPENS----IGVISPYNAQVSHLKKLIHDELKLTDI----EISTVDGFQGREKDVIILSLVRSNEKFE--------------VGFLKEERRLNVAMTRPRRQLVVVGNIEVL 653
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Yeast
Match: SEN1 (ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS [Source:SGD;Acc:S000004422]) HSP 1 Score: 97.8265 bits (242), Expect = 1.442e-20 Identity = 96/351 (27.35%), Postives = 154/351 (43.87%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFK-FTLIWGPPGTGKT-LVGCMIAYWYTILNKCDA------------------KPPPVLYCGPSNQSVNVVAEKLM-----KTFGRNCPKLLRIFNSDIM-----------FHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRK------------PGQPYAE--------KLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESL--KVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESG 4925
LN Q A+ NS + + F+LI GPPGTGKT + +I Y+ + N + K +L C PSN +V+ + +L K + P+L+R+ SD++ D Y + ++ PE + R+ P P + K+ E I ++ + E R++ + +RN ++ + A L + +II ST +GS +L ++ K +I+DE C+E ++ P + K +++GD QL P V S A + N SLF R+ K+ Y +LD QYRMHPSI +FPS FY + G
Sbjct: 1335 LNTSQAEAIVNSVSKEGFSLIQGPPGTGKTKTILGIIGYFLSTKNASSSNVIKVPLEKNSSNTEQLLKKQKILICAPSNAAVDEICLRLKSGVYDKQGHQFKPQLVRVGRSDVVNVAIKDLTLEELVDKRIGERNYEIRTD--PELERKFNNAVTKRRELRGKLDSESGNPESPMSTEDISKLQLKIRELSKIINELGRDRDEMREKNSVNYRNRDLDRRNAQAHILAVS--DIICSTLSGSAHDVLATMGIKFDTVIIDEACQCTELSSIIPL--RYGGKRCIMVGDPNQLPPTVLSGAASNFKYNQSLFVRMEKNSSPY--LLDVQYRMHPSISKFPSSEFYQGRLKDG 1677 HSP 2 Score: 63.929 bits (154), Expect = 2.937e-10 Identity = 51/179 (28.49%), Postives = 88/179 (49.16%), Query Frame = 3
Query: 5160 KILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFG--IFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
K I + QE+N + T + + + +E+V YL+R KI + I +I+ YR Q + KM +E FG I +T+ QG E + ++ S VR+ +D + +GF+ D + NVALTRA+ ++++G+ L+ +K+W+ I+D K R+C
Sbjct: 1698 KFFDIISGRQEQNAKTMSYTNMEEIR---VAIELVDYLFRKFDNKI----DFTGKIGIISPYREQ---MQKMRKEFARYFGGMINKSIDFNTIDGFQGQEKEIILISCVRA----DDTKSS---------VGFLKDFRRMNVALTRAKTSIWVLGHQRSLAKSKLWRDLIEDAKDRSCL 1853
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Yeast
Match: ECM32 (DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes [Source:SGD;Acc:S000000978]) HSP 1 Score: 96.6709 bits (239), Expect = 2.641e-20 Identity = 93/311 (29.90%), Postives = 145/311 (46.62%), Query Frame = 3
Query: 4047 LNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQE-NRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLK-VTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFER-LYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGI 4970
LN QK A+E+ N T++ GPPGTGKT + ++ + A P +L SN +++ +AEK+M+ R K+LRI + Y+ D L +I LH +V K P + + + KT+R + ++ E + ++ N K + + +II +T + + L+ +K +I+DE SE L P ++ +++ V +GD KQL S + QL SLFER L K +MLDTQYRMHP I EFP YN + G T ++W G+
Sbjct: 649 LNRSQKTAVEHVLNNSITILQGPPGTGKT--STIEEIIIQVIERFHAFP--ILCVAASNIAIDNIAEKIMEN--RPQIKILRILSKK--------KEQQYSDDHP-----LGEICLHNIVYKNLSPDMQ-------VVANKTRRGEMISKSEDTKFYKEKNRVTNKVVSQS------QIIFTTNIAAGGRELKVIKECPVVIMDEATQSSEASTLVP-LSLPGIRNFVFVGDEKQL-----SSFSNIPQLETSLFERVLSNGTYKNPLMLDTQYRMHPKISEFPIKKIYNGELKDG----VTDEQKAWPGV 917 HSP 2 Score: 55.8398 bits (133), Expect = 6.492e-8 Identity = 36/105 (34.29%), Postives = 57/105 (54.29%), Query Frame = 3
Query: 5391 NSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLL-SVNKMWKTFIDDLKKRNCFKNDI 5702
N I + V+TV QG E ++IFS VR+ N E+ +GF+ D+ + NVALTRA+ GL +VGN ++L + +WK +I L+++ D+
Sbjct: 1028 NVINIINGLHVATVDSFQGHEKSFIIFSCVRN--NTEN------------KIGFLRDKRRLNVALTRAKHGLIVVGNKNVLRKGDPLWKDYITYLEEQEVIFTDL 1118
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Yeast
Match: DNA2 (Tripartite DNA replication factor; single-stranded DNA-dependent ATPase, ATP-dependent nuclease, helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; component of telomeric chromatin with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress; human homolog DNA2 complements yeast dna2 mutant [Source:SGD;Acc:S000001207]) HSP 1 Score: 49.6766 bits (117), Expect = 5.075e-6 Identity = 33/100 (33.00%), Postives = 47/100 (47.00%), Query Frame = 3
Query: 4641 IILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESG--EVF 4934
+ILDE S P ALGP +++GDH QL P+V + A+ L SLF+ + + L QYRM I + Y++ + G EVF
Sbjct: 1183 VILDEASQISMPVALGPLRYGN---RFIMVGDHYQLPPLVKNDAARLGGLEESLFKTFCEKHPESVAELTLQYRMCGDIVTLSNFLIYDNKLKCGNNEVF 1279
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Nematostella
Match: EDO31025 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ42]) HSP 1 Score: 186.808 bits (473), Expect = 2.973e-52 Identity = 129/368 (35.05%), Postives = 186/368 (50.54%), Query Frame = 3
Query: 4575 EIILSTAAGSCKKLLESL--KVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPS---YKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFI 5663
EIIL T + S + L + Q+I+DECGMC EPE L P + K +VLIGDHKQL+PI+ AK L IS+FER K IML QYRMH IC FPS FY+ ++ LT+A T P V+ +P+ +++D+ R +F H +G EK+ I ++ SKSNE E ++ + L+ K ++++T YR Q+ + +E L++ +D +VST++KSQGSE DYVI S VRSLP ++I+ P+ W+ LGF+ DE+Q NVALTRAR+GL I+GN +L+ ++ W +
Sbjct: 1 EIILCTCSASGADRIVDLCDNIQQVIVDECGMCFEPETLVP-ITCARAKQVVLIGDHKQLQPIIKDNDAKRLGLEISMFERYAKK----AIMLKEQYRMHAEICHFPSEQFYD------KLLLTSATVALRTPSP-------------VDFWPAQVLHRKDVPR--------------------------------------VFCHVEGCEKSSVIKTQYSNHGSKSNEKEANKAVHVAKVLVNKYAVNHGD---VVILTPYRQQQV----LIKEGLHA--PYDDIQVSTIIKSQGSEWDYVILSLVRSLPK-DEIEAEPSSKWLGDNLGFLRDEHQINVALTRARRGLCIIGNKNLVELDPTWSALL 296
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Nematostella
Match: EDO31024 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ41]) HSP 1 Score: 185.267 bits (469), Expect = 4.543e-52 Identity = 124/347 (35.73%), Postives = 176/347 (50.72%), Query Frame = 3
Query: 4632 VTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPS---YKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFI 5663
+ Q+I+DECGMC EPE L P + K +VLIGDHKQL+PI+ AK L IS+FER K IML QYRMH IC FPS FY+ ++ LT+A T P V+ +P+ Y D+ R +F H +G EK+ I + QSKSNE E + ++ + L+ K ++++T YR Q+ + +E L++ +D +VST++KSQGSE DYVI S VRSLP ++I+ P+ W+ LGF+ DE+Q NVALTRAR+GL I+GN +L+ ++ W +
Sbjct: 2 IQQVIVDECGMCFEPETLVP-ITCARAKQVVLIGDHKQLQPIIKDNDAKRLGLEISMFERYAKK----AIMLKEQYRMHAEICHFPSEQFYD------KLLLTSATVALRTPSP-------------VDFWPAQVLYGNDVPR--------------------------------------VFCHVEGCEKSSVIKTQYSNQQSKSNEKEAKKAVHVAKVLVNKYAVNHGD---VVILTPYRQQQV----LIKEGLHA--PYDDIQVSTIIKSQGSEWDYVILSLVRSLPK-DEIEAEPSSKWLGDNLGFLRDEHQINVALTRARRGLCIIGNKNLVELDPTWSALL 276
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Nematostella
Match: EDO45137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTS2]) HSP 1 Score: 121.709 bits (304), Expect = 2.431e-27 Identity = 94/326 (28.83%), Postives = 153/326 (46.93%), Query Frame = 3
Query: 4014 LIKKKMTFECNLNLQ--------QKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRI---------QENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAA-GSCKKLLESLKVTQIILDECGMCSEPEALGPTMNK-TELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEK---YCIMLDTQYRMHPSICEFPSIHFYN--DSRE 4919
L +K + +C N++ Q A+ + T+++G PGTGK+ IA + N+ DA VL C P+ ++++VV+E L++ G + +RI++ +D G ++ALH VR P+++ L + S+ T+ + + + + + YN L A EL +II+ T A +++ + Q I+DE C EPE L P + VL+GDHKQL P++ S+ A L SLFE L+++ + C L+TQ+RMHPS+ +F S FYN SRE
Sbjct: 2343 LGRKILARQCETNMRVVPGLDDDQAHAVRTALTHPLTMVYGQPGTGKSWTAVAIACHFVNQNRADAAGH-VLLCAPTERALDVVSELLLQVPGI---RAVRIYSKQ---------AETTVIDGSG----HSNLALHMRVRHASNPHSKALLSCEAEISRLTQELTSCTDPTKQERTQHKLDSKRQKYNTILATAEGFELGETPVDIIICTCAEAGSQRMRTHANIAQCIVDESNYCLEPEVLVPAVTAGPRCSRFVLVGDHKQLVPVLQSKEAWKLGLGRSLFEDLWEAHREGSSACCTLNTQHRMHPSLGKFSSSFFYNVQQSRE 2651 HSP 2 Score: 65.855 bits (159), Expect = 2.113e-10 Identity = 36/90 (40.00%), Postives = 52/90 (57.78%), Query Frame = 3
Query: 5418 RVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNC 5687
R+++ + QG++ D ++ STVR P D P G+ G + D++Q NV LTRARKGL IVGN + LS N MW + D + +C
Sbjct: 2747 RLTSPEECQGAQCDVLVLSTVRGRP--RDQLTGPHGGF-----GCLGDKHQMNVVLTRARKGLVIVGNRYYLSGNPMWNRLLHDYEVLDC 2829
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Nematostella
Match: EDO36452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIH7]) HSP 1 Score: 99.3673 bits (246), Expect = 5.843e-24 Identity = 51/113 (45.13%), Postives = 77/113 (68.14%), Query Frame = 3
Query: 5325 ILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFI 5663
++++T YR Q+ + +E L++ +D +VST++KSQGSE DYVI S VRSLP E+I+ P+ W+ LGF+ DE+Q NVALTRAR+GL I+GN +L+ ++ W +
Sbjct: 23 VVILTPYRQQQV----LIKEGLHAP--YDDIQVSTIIKSQGSEWDYVILSLVRSLPK-EEIEAEPSSKWLGDNLGFLRDEHQINVALTRARRGLCIIGNKNLVELDPTWSALL 128
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Nematostella
Match: EDO30690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T022]) HSP 1 Score: 91.2781 bits (225), Expect = 3.577e-18 Identity = 119/424 (28.07%), Postives = 184/424 (43.40%), Query Frame = 3
Query: 4425 YAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPE---ALGPTMNKTELKHLVLIGDHKQLRPIVTS-RVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLL-SVNKMWKTFIDDLKKR 5681
Y E + +Q + + ++R+ E R+ + +I K A+ IG + +T A +++L+ +K II++E E AL P +HL+LIGDH+QLRP T ++AK L+ISLFER+ +K + L Q+RM P I + LQ++ YP + NH ++ + IKG V I FI Q +E+ E +S+SN E + V L R L I++ S+ I V+T Y Q L K E+ F F+ RVS V QG E+D ++ S VRS + D N +GF+ N+ VAL+RARKG + +GN L+ ++WK +DDL+++
Sbjct: 774 YKETVIMHQDEYVEVSQRLNEARR-----IEDISILRKAAV-----IG----MTTTGAAKYREVLQEIKPRIIIVEEAAEVLEAHIVTALSPG-----CQHLILIGDHEQLRPNPTVYKLAKDYHLDISLFERVVNNK-MHLECLRKQHRMRPEISQM---------------------------------------LQHI--YPDLE-----NHESVLNFDNIKG--------------------VSTNIFFIDHQEREEFIE------EGRSRSNIHEAKFVAALCRYL---ILQGYERSK-ITVLTMYTGQLLQLKK---EMPKDF--FNGVRVSAVDNFQGEENDIILLSLVRS-----NDDGN---------IGFLRISNRVCVALSRARKGFYCIGNMGLMEEKEELWKKILDDLRQK 1082
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Medaka
Match: ENSORLT00000013379.2 (helicase with zinc finger 2 [Source:NCBI gene;Acc:101162116]) HSP 1 Score: 201.83 bits (512), Expect = 3.426e-51 Identity = 208/727 (28.61%), Postives = 313/727 (43.05%), Query Frame = 3
Query: 2853 PFLNEVNHDNF-ILFRLLGLNRVPIESSNEGCSVVALNWKTRIFIDGPENCQEFQNSEIDITDIYSYYFRIWRYXXXXXXXXXXXXXXXXXXXXXNQY--------PNRLTSEIIDNINPMITLKQKIIDRQL-----IRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLL-KDENVIGKKNRDYNIQLTFKLMHSNFPIKNL------ENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKR-EFYETDKKHLDYQLIKKKMTFEC-NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDA------------KPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAG-----APYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAA-GSCKKLLESLKVTQIILDECGMCSEPEALGPTM-NKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKS-KEKYCIMLDTQYRMHPSICEFPSIHFY 4904
PF V H I++ L L P+ NE V L WK RI+I N Q N+ +D +WR + E D K + Q P L+ + ++ +D QL +++Q + G +L+ I F +C+ H P F P + + NI++YK + L +E + S I DL++ S + +Q + G + + W+ L H I L A E T + WV HG KD+ +G K + F + H P++N+ N + +E + + E ++ L+ + +I RKR + L +Q+ +KK+ + LN Q A+ + N FTLI GPPGTGKT+VG I +W+ +N K +LYCGPSN+SV+VVAE LM+ ++ +LLR+++ + D+P +P L + L+ I LH +R+ P+A+ + ++ +RI+ N + Y LKKA ELE ++IIL T S L S+ QI++DEC M +EP+AL P + NK E +VLIGDHKQLRPIV + K ++ SLFE + EK +MLDTQYRMH ICEFPS FY
Sbjct: 1999 PFNMSVFHRTMSIMYADLQLEDQPL--FNEVNHAVTLTWKKRIYIAESSNVQLNLNTILDCGPCVKIPLAVWRDAMEAIENQDLDCAKSLLLQVNTQPWENPMLQPPTPLSKTSACSTEKKLSESWTNVDLQLQPGDRLQVQMTSEKRRGYHMPTIQLVHIKKHFEICIDHVHRPVVCFSKPSNDPSRYF--YNNINQYKEIWKPLCEMESASTAVDDCESVIIEDLEI-------SFSQTQCDKLTGTFFLPELWTREFEFSLRHCFLCIRKRNLELTAASE---------FSTQVDPTQFTWVAHGVTSYVEEKEKDQKKVGSK-------VDFFINH--LPMENIPKCIFQSNTCFTVEIIPKLLPDIRKEGAVVNLEKACDLVKSIILRKRIKTPVVQYSMLRFQVKRKKLPGDLPELNDSQSQAVTTAINEPFTLIQGPPGTGKTVVGVYIVHWFLEMNSKTPRIFDDPYDEHRNKKEVILYCGPSNKSVDVVAEYLMRL--KDSLRLLRVYSHHVEMLDYPYPDSTLQFSPKTLRQDRSKPELRSITLHHRMRENPNPHADDIRKFD-------ERIRRNEDFTQKEIEEYKDLLKKARVHELE--QHDIILCTCTQSSTPSLSRSVSARQILIDECAMATEPQALIPLVCNKPE--KVVLIGDHKQLRPIVKNESVKKLGMSRSLFESYFNQLSEKKAVMLDTQYRMHEDICEFPSEKFY 2683
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Medaka
Match: UPF1 (UPF1 RNA helicase and ATPase [Source:NCBI gene;Acc:101168695]) HSP 1 Score: 149.443 bits (376), Expect = 1.125e-35 Identity = 160/605 (26.45%), Postives = 245/605 (40.50%), Query Frame = 3
Query: 3906 FERSLRKLKTGTFSEELV---IDRKREFYETDKKHLDYQLIKKKMTFEC--NLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKT---FGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSF--GIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCF 5690
F+R LKT E V I K +E + + QL K+ T + +LN Q A++ +LI GPPGTGKT+ I Y + PVL C PSN +V+ + EK+ KT R C K S + F +ALH + + + E Q K +++++ E + LK+ ++EL + N ++I T G+ L ++ I++DE +EPE + P + K L+L+GDH QL P+V + A L+ SLFERL + I L QYRMHP++ FPS FY S + N + AD +KK DF P + + F TQGQE EI+ + S +++ VE + +++K + I +IT Y Q L + Q S ++ +++V QG E D++I S VR+ N G +GF+ D + NVALTRA+ G+ IVGN LS +W +++ K++
Sbjct: 401 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVTIKCQL-PKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLSRQGNG-----PVLVCAPSNIAVDQLTEKIDKTGLKVVRLCAKSREAIESPVSF-----------------------LALHNQISN-----MDSMPELQ-----KLQQLKDETGELSSADEKRYRALKRTAEREL-LMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV--LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR-PIRLQVQYRMHPALSAFPSNIFYEGSLQ--------------------------------------------NGVTAADR--------------IKKGFDFQWPQPDKPMFFYVTQGQE---EIASSGTSYLNRTEAANVEKIT-------TRLLKAGAKPDQIGIITPYEGQRSYLVQYMQ-FSGSLHTKLYQQVEIASVDAFQGREKDFIILSCVRA---------NEHQG-----IGFLNDPRRLNVALTRAKYGVIIVGNPKALSKQPLWNNLLNNYKEQKVL 879
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Medaka
Match: MOV10 (Mov10 RISC complex RNA helicase [Source:NCBI gene;Acc:101175158]) HSP 1 Score: 95.5153 bits (236), Expect = 3.607e-19 Identity = 122/535 (22.80%), Postives = 214/535 (40.00%), Query Frame = 3
Query: 4101 LIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMN--KTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFER------LYKSKE-----KYCIMLDTQYRMHPSICEFPSIHFYNDSRES-GEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFI 5663
L++GPPGTGKT+ C +L C PSN + +++ K+++ R+ K+ R++ + + D + P++LKD++ + V P E L EY+ + + + + + + +G++ T + +DE G E E L P LVL GD KQL PI+ S A + +SL ER LY+ E ++ L YR HP+I + P+ FY+ + E + ++ C W +P + F+G+ ++ +E + N+A+ ++ +D+ +K+L QG++ +I+ E+ ++ YR ++KI + V +RL + N K V +V + QG E ++ STVRS + DK + LGF+ +E +FNVA+TRA+ L +VGN +L + W F+
Sbjct: 546 LVFGPPGTGKTVTVVEAIKQIEKFQTCCH----ILACAPSNSAADLLCTKILEHVDRH--KVYRMYAT--------------SRDPKLVPDHLKDVS-NLVGECYEFPSKETLMEYKILVTTL-------------------LTAGRLVSGAIPVGHF--------------------THVFVDEAGHAVETECLVPIAGLFDASFCQLVLAGDPKQLGPILRSPFALKYGMGVSLLERLMNNFPLYQKNEGDYNKRFVTKLLRNYRSHPAILKIPNDLFYDGELQPCAEEYSCSSYC-FWRHLPKMEFPVIFHGVAGLD----EREKTSPSFFNVAE---------------IEVLMDY-----VQKLL--EAQGKKGEPKIAPK-----------EIGIIA-PYRKQVQKIRRALEK-----VGQNFRLLDMNALK----------------VGSVEEFQGQERRVILVSTVRSSSEYMEFDKKFS-------LGFVKNEKRFNVAVTRAKALLIVVGNPVVLKTDPTWARFL 953
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Medaka
Match: ighmbp2 (immunoglobulin mu DNA binding protein 2 [Source:NCBI gene;Acc:101158519]) HSP 1 Score: 72.0182 bits (175), Expect = 5.926e-12 Identity = 74/298 (24.83%), Postives = 125/298 (41.95%), Query Frame = 3
Query: 4035 FECNLNLQQKLALENS-ANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIA--LHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCK----KLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCI-MLDTQYRMHPSICEFPSIHFY 4904
F NL+ Q+ A+ + + + +I GPPGTGKT I+ + + VL C PSN +V+ + E+L + K+LR+ + + L + DI + V+ + E+ N + I K + QI + ++ +LST G+C KLL + +++DEC E + + + +L GD+KQL P + S+ A +K L++SL ER+ + + ML QYRM+ +I E+ S Y
Sbjct: 186 FNSNLDDSQREAVMFALSQRELAVIHGPPGTGKTTT------VVEIILQAVKQGQKVLCCAPSNVAVDNLVERLAQCKA----KVLRLGHPARLLESIQKHSLDAILAQSDNANIIADIRKDIDKVLMGMKKEKGERGNYKREIGELKKELKSREATAITQILKGADV-----------------VLSTNTGACDDGPLKLLPAEHFDWVVIDECAQALESSCWIALL---KARKCILAGDYKQLPPTIKSQAAASKGLSLSLMERVIQIYGDVVVRMLTVQYRMNSAIMEWASKEMY 453
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Medaka
Match: ENSORLT00000034865.1 (putative helicase mov-10-B.2 [Source:NCBI gene;Acc:101175667]) HSP 1 Score: 68.5514 bits (166), Expect = 6.555e-11 Identity = 49/145 (33.79%), Postives = 75/145 (51.72%), Query Frame = 3
Query: 5241 NELEVEVVKYLYRTLLKKIIKEKSASQC---ILVITQYRLQEYNLNKMCQEILN-SFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFI 5663
N E+EV+K ++L++ + + + I +I+ YR Q + K Q + S + V TV K QG E ++ STVR P ++ + LGFI D+ +FNVA+TRAR L +VG+ LL+ +K W TFI
Sbjct: 686 NMAEIEVIKEYLKSLIQHLHRNNVSHVPPGEIGIISPYRKQVEKIQKAIQWDADLSKENLENVEVGTVDKFQGKEFSVILMSTVRCFPKLKHKQ--------NFILGFIRDDRRFNVAMTRARSLLVVVGDPRLLATDKNWNTFI 822 HSP 2 Score: 65.4698 bits (158), Expect = 5.103e-10 Identity = 77/306 (25.16%), Postives = 120/306 (39.22%), Query Frame = 3
Query: 4035 FECNLNLQQKLA--LENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELK--HLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKY------------CIMLDTQYRMHPSICEFPSIHFY 4904
FE N Q+ + L +A L+ GPPGTGKTL I+ A+ +L C PSN + + + EK++K + ++D ++ +P LH + + P E L + + +K N+K +I +K L L+ TA + T I +DE G +E E++ P + +VL GD KQL P+V S+ A+ L +SL ERL + + Y L YR HP+I + P+ FY
Sbjct: 392 FEFNPEQQKAVTHILRRTAKPAAYLLCGPPGTGKTLTLVK-----AIMEIVKAQDINILVCAPSNSASDDICEKILKG----------LVDTDKVYRLYPL--------------------LHSIAKIP-----EILKKNCNLDQKKGTIKIPNKK---------SIMSRKILVTTLQ---------TAGRLVTGGIPPKHYTYIFVDEAGQATETESMIPIAGLCDRSTCQVVLAGDPKQLGPVVISKTAEYHGLGVSLLERLMRDNDLYKPHEDFGFDSNFITKLLKNYRSHPAILKVPNDLFY 639
BLAST of Helicase with zinc finger domain 2 vs. Planmine SMEST
Match: SMESG000017486.1 (SMESG000017486.1) HSP 1 Score: 2054.64 bits (5322), Expect = 0.000e+0 Identity = 1016/1018 (99.80%), Postives = 1018/1018 (100.00%), Query Frame = 3
Query: 2661 MKGDSNVTWDIDGHLEKYQTFKIVFDKYWKICRAYEIKNQFDGDSFILDCVFEGFSEEKMFFQHPFLNEVNHDNFILFRLLGLNRVPIESSNEGCSVVALNWKTRIFIDGPENCQEFQNSEIDITDIYSYYFRIWRYXXXXXXXXXXXXXXXXXXXXXNQYPNRLTSEIIDNINPMITLKQKIIDRQLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNFPIKNLENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILELF 5714
MKGDSNVTWDIDGHLEKYQTFKIVFDKYWKICRAYEIKNQFDGDSFILDCVFEGFSEEKMFFQHPFLNEVNHDNFILFRLLGLNRVPIESSNEGCSVVALNWKTRIFIDGPENCQEFQNSEIDITDIYSYYFRIWRYKIITSEIDSDDIEKIEEILDKNQYPNRLTSEIIDNINPMITLKQKIIDRQLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKL+HSNFPIKNLENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYT+LNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILELF
Sbjct: 1 MKGDSNVTWDIDGHLEKYQTFKIVFDKYWKICRAYEIKNQFDGDSFILDCVFEGFSEEKMFFQHPFLNEVNHDNFILFRLLGLNRVPIESSNEGCSVVALNWKTRIFIDGPENCQEFQNSEIDITDIYSYYFRIWRYKIITSEIDSDDIEKIEEILDKNQYPNRLTSEIIDNINPMITLKQKIIDRQLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLVHSNFPIKNLENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTLLNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILELF 1018
BLAST of Helicase with zinc finger domain 2 vs. Planmine SMEST
Match: SMESG000017490.1 (SMESG000017490.1) HSP 1 Score: 1366.67 bits (3536), Expect = 0.000e+0 Identity = 738/742 (99.46%), Postives = 739/742 (99.60%), Query Frame = 3
Query: 123 MNVNNKDDEWHTISRXXXXXXXXXXXXXXXTFQIMRPNDCIVXXXXXXXXXXXXXXXKIKLENPLFWNQFALIGNIKKQVHEILMKYQIFPKYRVMELSHCVNTISRNTITNNDLYNEFDYIMDNLNRTIKFVSIIPRFTEREYGRGDKIYMIHIRFNHYLVADSKLMQFNKDFLFGFEEYHGFLGVTPTHIPITNDSTASGKNRENLIKVMKTVKNKRSSDFFQPDHEGNDEKSDKKSDTKIPYYVPFQFEKLSKNDKTFNCKLFLEDAHSGYGEILEGSKKGNKIYLHNRKNCGQAFCGDIVKILVFQNSADKITKPNKKLKKFREENKQLTGRVISVISSEVKPINKIFLCHLLNGTTNLMTPICNTIPVIYVDNKHAVEATKKHCNNLKEMNVVGIQNIIQKTIPVVISDSFANKSFVTLKDLHDNLTTTVNSVYYVDCYTCEYIFLVLYRNWDNCHRFPDGEVVGIYTPDVNFENTLNIIKITCDVPVIGIDEEQSFHXXXXXXXXXXXXXXXXXXSDRTVFSFKQPNKEFNEMAFSYKNLTDNTFEVGVHVTNVCKYIQQNEFLDTLSVNRFFTFLLPNLNFSQNSTVQSDYLLSKALSNEFSINLGKPTDVISFYFQVNDELQILQSXXXXXXXXXXXXELDSKKCDNLINSRNENFKFLRDIFKFCSNRAKTLEHVLPVDCFYPNFKLKIDQSAYIIDEVLKQLTNETSQIEYLDSSNNFPHQLNKWYEEIKQL 2348
MNVNNKDDEWHTISRNKKDKIKNDSINNKSTFQIMRPNDCIVNNDNNLDDRENEHEEKIKLENPLFWNQFALIGNIKKQVHEILMKYQIFPKYRVMELSHCVNTISRNTITNNDLYNEFDYIMDNLNRTIKFVSIIPRFTEREYGRGDKIYMIHIRFNHYLVADSKLMQFNKDFLFGFEEYHGFLGVTPTHIPITNDSTASGKNRENLIKVMKTVKNKRSSDFFQPDHEGNDEKSDKKSDTKIPYYVPFQFEKLSKNDKTFNCKLFLEDAHSGYGEILEGSKKGNKIYLHNRKNCGQAFCGDIVKILVFQNSADKITKPNKKLKKFREENKQLTGRVISVISSEVKPINKIFLCHLLNGTTNLMTPICNTIPVIYVDNKHAVEATKKHCNNLKEMNVVGIQNIIQKTIPVVISDSFANKSFVTLKDLHDNLTTTVNSVYYVDCYTCEYIFLVLYRNWDNCHRFPDGEVVGIYTPDVNFENTLNIIKITCDVPVIGIDEEQSFHIEIANIKKIKMKISNVKKSDRTVFSFKQPNKEFNEMAFSYKNLTDNTFEVGVHVTNVCKYIQQNEFLDTLSVNRFFTFLLPNLNFSQNSTVQSDYLLSKALSNEFSINLGKPTDVISFYFQVNDELQILQSPIPIDDIVVLDLELDSKKCDNLINSRNENFKFLRDIFKFCSNRAKTLEHVLP DCFYPNFKLKI+QSAYIIDEVLKQLTNETSQIEYLDSSNNFPHQLNKWYEEIK
Sbjct: 1 MNVNNKDDEWHTISRNKKDKIKNDSINNKSTFQIMRPNDCIVNNDNNLDDRENEHEEKIKLENPLFWNQFALIGNIKKQVHEILMKYQIFPKYRVMELSHCVNTISRNTITNNDLYNEFDYIMDNLNRTIKFVSIIPRFTEREYGRGDKIYMIHIRFNHYLVADSKLMQFNKDFLFGFEEYHGFLGVTPTHIPITNDSTASGKNRENLIKVMKTVKNKRSSDFFQPDHEGNDEKSDKKSDTKIPYYVPFQFEKLSKNDKTFNCKLFLEDAHSGYGEILEGSKKGNKIYLHNRKNCGQAFCGDIVKILVFQNSADKITKPNKKLKKFREENKQLTGRVISVISSEVKPINKIFLCHLLNGTTNLMTPICNTIPVIYVDNKHAVEATKKHCNNLKEMNVVGIQNIIQKTIPVVISDSFANKSFVTLKDLHDNLTTTVNSVYYVDCYTCEYIFLVLYRNWDNCHRFPDGEVVGIYTPDVNFENTLNIIKITCDVPVIGIDEEQSFHIEIANIKKIKMKISNVKKSDRTVFSFKQPNKEFNEMAFSYKNLTDNTFEVGVHVTNVCKYIQQNEFLDTLSVNRFFTFLLPNLNFSQNSTVQSDYLLSKALSNEFSINLGKPTDVISFYFQVNDELQILQSPIPIDDIVVLDLELDSKKCDNLINSRNENFKFLRDIFKFCSNRAKTLEHVLPADCFYPNFKLKINQSAYIIDEVLKQLTNETSQIEYLDSSNNFPHQLNKWYEEIKSF 742
BLAST of Helicase with zinc finger domain 2 vs. Planmine SMEST
Match: SMESG000017486.1 (SMESG000017486.1) HSP 1 Score: 968.763 bits (2503), Expect = 0.000e+0 Identity = 468/468 (100.00%), Postives = 468/468 (100.00%), Query Frame = 3
Query: 4311 MFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILELF 5714
MFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILELF
Sbjct: 1 MFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTELKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRRNHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDILELF 468
BLAST of Helicase with zinc finger domain 2 vs. Planmine SMEST
Match: SMESG000026073.1 (SMESG000026073.1) HSP 1 Score: 615.15 bits (1585), Expect = 0.000e+0 Identity = 548/1827 (29.99%), Postives = 868/1827 (47.51%), Query Frame = 3
Query: 537 FTEREYGRGDK--IYMIHIRFNHYLVADSKLMQFNKDFLFGFEEYHGFLGVTPTHIPITNDSTASGKNRENLIKVMKTVKNKRSSDFFQPDHEGNDEKSDKKSDTKIPY--YVPFQFEKLSKNDKTFNCKLFLEDAHSGYGEILEGSK--KGNKIYLHNRKNCG-QAFCGDIVKILVFQNSADKITKPNKKLKKFREENKQLTGRVISVISSEVKPINKIFLCHLLNGTTNLMTPICNTIPVIYVDNKHAVEATKKHCNNLKEMNVVGIQNIIQKTIPVVISD--SFANKSFVTLKDLHDNLTTTVNSVYYVDCY-----TCEYIFLVLYRNWDNCHRFPDGEVVGIYTPDVNFENTLNIIKITCDVPVIGIDEE-QSFHXXXXXXXXXXXXXXXXXXSDRTVFSFKQPNKEFNEMAFSYKNLTDNTFEVGVHVTNVCKYIQQNEFLDTLSVNRFFTFLLPNLNFSQNSTVQSDYLLSKALSNE-FSINLGKPTDVISFYFQVNDELQI-------------LQSXXXXXXXXXXXXELDS--KKCDNLINSRNENFKFLRDIFKFCS--NRAKTLEH--VLPVDCFYPNFKLKIDQSAYIIDEVLKQLTNETSQIEYLDSSNNFP--------HQLNKWYEEIKQLCNVTLSPIMKQVIRKINENFTNNNSL-KLRASKQFLEKVYNCQEVNLFRCESLFPDIGFYHKQFELITNIKIKNYLEKLNCKC----------------LSITNPLSCYLDIFSQRVLLDRMKGDS--NVTWDIDGHLEKYQTFKIVFDK-YWKICRAYEIKNQFDGD-SFILDCVFEGFSEEKMFFQHPFLNEVNHDNFILFRLLGLNRVPIESSN-EGCSVVALNWKTRIFIDGP-----ENCQEF--QNSEIDITDIYSYY--FRIWRYXXXXXXXXXXXXXXXXXXXXXNQYPNRLTSEIIDNINPMITLKQKIIDRQLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELKRINY----KRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNFPI--KNLENQQYLLE-FMESPISTRIFERSLRKLKTGTFSEELVI-------DRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAG--APYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLNEYQTIF-----SQKTKRIQEN-RKEFAQIFRNYNICLKKALQKELEIGN-YEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTE--LKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGI-PDNKHNATF---NGLQYVNLYPSYKEDLRR-NHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDIL 5705
F E YG + I+++HI ++L S ++ F F EE + + T D A + R+ L + K + + + P N K K+ Y Y P E+LSK C L +AHSG ++ S K +I L +R NCG AF DIV + KI P K TG+V+ V S KP+N I++C + +LM+P+ + P I+VDN+ + N+++ IQN QK++ + + FA+ + ++ + N + + D TC++ F+V Y WD +P+G++VG + +F+N +I + C + + I Q EI + +D VF+ + + A S+ + +GVH+T+V KYI + + +RF T+ P S + +LL L+ + S+ KP V+S F+ + I + + I + E+ S K+ + + N + L +IF RA+ E V V+ Y + ++ A I+ E L NE + + +F +W E + L N+ + +K+ +N N ++ KL SK F E+ N +++ + SL +Y+ F I NY + C T+P+ + DI R+L + G ++T DI G + K+ +K + KIC + I ++ D FILDC + E++ F HP L + + I F L LN VP+ N E L WK I+ P N + F NS+ D +S Y F+ R + + D + +++ + ++S+ I NP+I ++ KI + +RIQF +G+ I PEL I++P F++CL HR DP +F+ +LK +N+ K F +I EY+ F L +E + +T+G S+F++ D+ ++W+ ++ +E YG++ + + +SR + +R L E + LLC++ N N YW+GHG V K E + ++ I + F L S+F I N Q Y ++ +++S +S R E ++ + T +E+++ D + F + K ++ + I K N Q A+ N+ N K +LIWGPPGTGKT +GC+++Y + N VLYCGPSN VN+VA ++ K F CPKLLRI+ DFP G + N+ G L+ I+LH+++R+ G+ +A+ L+ + F + + + EN R+ +Y +K+A +K L I N YE++L T + ++E +TQII+DE GMC EPE L P M+ E ++++VLIGDHKQLRPI+ ++VAK L ISLFER + K K ML+ QYRMHPSICEFPS FY L T V W+G+ PD+ ++ NG+ Y Y+ LR+ N+ + D+ W R +KC K F P E+I+F H G E Q ++ TG+ S+ N EVE V +Y+ +++ + + + I V+TQY+LQ++ L C++IL I P V TV++SQGS++DY+IFSTVRS+ N EDI+++PT GW +YLGFITD NQ NVALTRA+KGL I+GN LL VN +WK I DL++RNC K D L
Sbjct: 202 FKEIIYGSNLQRCIHLLHIGMQYFLPLQSGIL--TNTFTFSKEETKLISDLKQLNANSTVDQYAVDQERKRLNDIRKMLMGMEKQETYVPMVNPNSRK-------KLLYEIYTP---EQLSKRTDLIKCILKFTNAHSGRAIPVDRSADMKYKEIKLISRHNCGYNAFQNDIVYV--------KINDP-----------KNHTGKVMGVYESNHKPVNSIYICKVSRDQGSLMSPLDKSFPKIHVDNEPG--RRRYEVNDMERKKTKNIQN-EQKSVADLEQELSRFADNLYYSVFKIKVNKNSDKPIYFPKDVVPFNPETCDHFFIVCYEYWDPYFMYPNGKIVGTISSYDSFKNNFPLISLICQINPLDITPRYQKEVDEIKKKAVCVHVPGSYLPTDSVVFTIDSETTKDMDDALSFHKEGSDII-IGVHITDVTKYISPTHEIYKQAESRFCTYYPPKF-----SNIHPIHLLDDTLATDVLSLAPNKPRAVVSVLFRFPGRMLINPDFKLSEIIQPTFRQGVIISQFKLTYEEVSSWLKQPNQIPNDKENLIYALNEIFAVAKKIRRARLPESYFVCSVNDCYKDMDIETIFEARIVIEEFMLLANEYVARKIYEKYPDFTLLRMQDPVKNCGEWLENLFNLTNMNFAGQLKEFCNLLNVRPDNFDARKKLIVSKNFYEQFNNFLSIDIDKARSLLQYDAYYNDFFVHIREWYQMNYPARYECSVKDSIENKHFSLNKPLYTHFTSPIRRFTDIVVHRLLKSVLNGTEIDDITLDI-GEVCTIANKKLNGNKNFEKICAPFAIFDETDKKFCFILDCACSDITNEEIRFVHPMLQKASSIKEIKFADLSLNAVPLSLKNDEKAESCLLKWKKIIYSCNPYFKSTSNRRNFVVDNSQFDCHLPFSSYKLFQEIRRSYLPAVKLKDKLHQLKSSFVNQTFDTVISSDSISLANPIIDIELKIFIKNTMRIQFCKYKVNGLPAIKPELHIVSPTFQICLIHRDDPVPFFIPGGKLK-LNHNTIKKVFTDIKEYQDYFSPLVHVESLQETLGEPSAFTLIDVTIEWLVGESLITKRKER--YGVMKLPDDFCKSRNIIFNDERDSNGSRYEVLLERGFSSVGGDLLCLRLKKDNWNNYWIGHGEVVHVAKPKLE------SGEFKI-VIFMLTQSDFDIFSNNSNIQNYSVDVYLKSVVSKRQQE-AISSIDTHPLLKEVILGINELSPDDENNFINSIKNDIENRRIFK-------FNQNQSQAMSNAMNHKLSLIWGPPGTGKTHIGCILSYAFAQKNYRIRNKGVVLYCGPSNDCVNLVALEMKKKFSDLCPKLLRIYGEQQELADFPLPGFFSKTNVPLTG---ELQQISLHYLIRQQGESHADILSSHDRYFQKILTTDRNYSLSENIREAIHNSILSYRDAVKEA-KKNLIIKNQYEMVLCTTTVTATTIMELFNITQIIIDEAGMCKEPETLIP-MSSAENTVENVVLIGDHKQLRPIIHNKVAKKLGLEISLFERYQELKPKLVTMLNYQYRMHPSICEFPSKEFYFHQ-------LKTQVSPLWSGLGPDDMEKCSYSQWNGINYRLCKLHYESILRQSNYSAVPDDKW--PAFRHIPYKCFNK--GFIRYP--ERIVFYHVIGDEVIQPVTTQTGNENSRGNPQEVEAVGCIYKKIIENLTPPRQSPNFITVLTQYKLQQHLLEMKCKDILQKKKIKTDPIVKTVIRSQGSQNDYIIFSTVRSIRNREDINQHPTIGWEKQYLGFITDPNQINVALTRAQKGLIIIGNKQLLRVNHIWKRLIQDLEERNCVKEDYL 1951
BLAST of Helicase with zinc finger domain 2 vs. Planmine SMEST
Match: SMESG000026051.1 (SMESG000026051.1) HSP 1 Score: 523.087 bits (1346), Expect = 4.330e-154 Identity = 349/1066 (32.74%), Postives = 563/1066 (52.81%), Query Frame = 3
Query: 2604 TNPLSCYLDIFSQRVLLDRMKGDSNVTWDIDGHL------EKYQTFKIVFDKYWKICRAYEIKNQFDGDSFILDCVFEGFSEEKMFFQHPFLNEVNHDNFILFRLLGLNRVPI--ESSNEGCSVVALNWKTRIFIDGPENCQEFQNS-----------EIDITDIYSYYFRIWRYXXXXXXXXXXXXXXXXXXXXXNQYPNRLTSEIIDNINPMITLKQKIIDRQLIRIQFGYDYSSGIMNIVPELLIINPDFRVCLCHRSDPFKYFMHPDELK---RINYKRFKNISEYKSQFIILNRIEGIHQTIGSNSSFSIHDLKVDWISRQNSNNGSQETDIYGIVIIKKSWSESRFLKLTHDRTFILDPVNALREAVEKNKMDYLLCIQTFIVNKNIYWVGHGRVCDACLLKDENVIGKKNRDYNIQLTFKLMHSNFPIKNL--ENQQYLLEFMESPISTRIFERSLRKLKTGTFSEELVIDRKREFYETDKKHLDYQLIKKKMTFECNLNLQQKLALENSANFKFTLIWGPPGTGKTLVGCMIAYWYTILNKCDAKPPPVLYCGPSNQSVNVVAEKLMKTFGRNCPKLLRIFNSDIMFHDFPCAGAPYNLDSEGCPEYLKDIALHFVVRKPGQPYAEKLN----EYQTIFSQKTKRIQENRKEFAQIFRNYNICLKKALQKELEIGNYEIILSTAAGSCKKLLESLKVTQIILDECGMCSEPEALGPTMNKTE--LKHLVLIGDHKQLRPIVTSRVAKAKQLNISLFERLYKSKEKYCIMLDTQYRMHPSICEFPSIHFYNDSRESGEVFLTTAVCESWTGIPDNKHNATFNGLQYVNLYPSYKEDLRR--NHINIADEFWIKGGQRKNNFKCLKKDIDFNGPPVYEKILFIHTQGQEKNQEISCTTGSNQSKSNELEVEVVKYLYRTLLKKIIKEKSASQCILVITQYRLQEYNLNKMCQEILNSFGIFDLPRVSTVVKSQGSESDYVIFSTVRSLPNIEDIDKNPTPGWISKYLGFITDENQFNVALTRARKGLFIVGNSHLLSVNKMWKTFIDDLKKRNCFKNDIL 5705
T+P+ + DI R+L + G +D H +KY++ D++ +IC +Y + FILDC +E+ + H L + + F L L+ +P E + C+ L W+ I+ N + +S + ++ S F R + + ++ + ++Y ++S++ NP+I ++ ++ + +RIQF + G+ I PEL I+ P F++CL H+ DP ++F+ +LK IN RF I+EYK F L E + +T+ + SF++ +++ WI + S NG + YG++++ + + + + + + +++ I++ L + LLC++ + N YW+GHG V A + EN I Y I + F L HS+F + + Y ++ + TR + ++ L+ ++++ + D L+ +KM + N QK A+ + KF+LIWGPPGTGKT +GC +++ YT N + VLYCGPSN V++VA L K F +CPKLLRI++ DFP G + + + + +K +LHF++RK G + + L ++++I K +E + Q NY L KA + + Y+I+L T + + K+++S +TQ+I+DE GMC EPE L P ++K E +K++VLIGDHKQLRPI+ SR+A++ L ISLFER +L+ QYRMHPSICEFPS FY+ ++ L + + + + + ++ +NGL NL ++LRR N++ I DE W + + N C D F+ P E+ +FI G E Q ++ +TG+ SK N+ EVEV Y+YR ++I+ + ++ I ++TQY+LQ++ L CQ+IL S I P V TV++SQGSE+DY+IFSTVRSL N DI+ +PT GW +YLGFITD +Q NVALTRA+KGL IVGN LL VN+ WK I++ +RNC N+ L
Sbjct: 833 TSPIRRFSDIVVHRLLKSVINGKMIDDSSLDIHYVCSIANQKYKSN----DRFEEICASYTVFEDNKTFCFILDCTCSEINEDGIVVAHHLLQKSLSLKTMKFSYLTLSDLPFFKEEKTDNCT---LKWRRIIYSCSTSNIENNTDSTGTFVIDKDLYNVSLSSEASKEFGAIRRSCTHGQTLKEKLQNFKSKFIVSKYNTLISSDLYSIFNPIIDIQLQVFVKSTMRIQFSKNKVHGLPKITPELYIVTPTFQICLIHQDDPVRFFVQDGKLKLKYNINKTRFTTIAEYKEYFEPLIHAESLEETLSGDISFTLLSVQIKWILKVYSPNGKKVR--YGVIMLPEKFCQEKNIHFSDEKSDIINRYEHLIDEELSPIGSDLLCLRFKCASWNNYWIGHGEVVHASKFQQENTI------YKI-IIFLLTHSDFDAFSTIQDKNTYSVDVYNKSVVTRRQQLLMKSLEENELVCDIIMGKDLSIDNIDCG----TLVTEKM---FSFNKSQKQAMIRALKHKFSLIWGPPGTGKTFIGCCLSFEYTQRNL--STENVVLYCGPSNDCVDLVANYLRKQFNESCPKLLRIYSKQQELTDFPVPGY-FVRNCQPLSDEMKPFSLHFLIRKEGN-FVDLLRVCDEKFRSILQSKKCNPEERLHDLIQ---NYKGLLLKAKRDYVSKVKYDIVLCTTSVTATKIMKSFNITQVIVDEAGMCKEPETLIP-ISKMENSIKNIVLIGDHKQLRPIILSRLAESHGLQISLFERYQNLPNGVVTLLNFQYRMHPSICEFPSKEFYSSKLKTQASILWSGLTANDLRVEQDYYDNEWNGLDSFNLAGFEFDELRRKSNYLVIKDEKWPRRDDKPYN--CF--DRKFSWYP--ERTIFIDIIGTEVAQSVTTSTGNENSKGNKTEVEVCGYIYR----RLIESGAQARSISILTQYKLQQHLLKLNCQDILKSKKIMSDPIVKTVIRSQGSENDYIIFSTVRSLTNKNDINTHPTQGWERQYLGFITDPHQINVALTRAKKGLIIVGNRQLLQVNETWKKIINNYSERNCIVNNYL 1857 HSP 2 Score: 112.079 bits (279), Expect = 3.226e-24 Identity = 114/393 (29.01%), Postives = 178/393 (45.29%), Query Frame = 3
Query: 858 YVPFQFEKLSKNDKTFNCKLFLEDAHSGYG-EILEGSKKGNKIYLHNRKNCG-QAFCGDIVKILVFQNSADKITKPNKKLKKFREENKQLTGRVISVISSEVKPINKIFLCHLLNGTTNLMTPICNTIPVIYVDNKHA-----VEATKKHCNNLKEMNVVGIQNIIQKTIPVVISDSF--ANKSFVTLKDLHDN---LTTTVNSVYYVDCYTCEYIFLVLYRNWDNCHRFPDGEVVGIYTPDVNFENTLNIIKITCDVPVIGIDEEQSFHXXXXXXXXXXXXXXXXXX-SDRTVFSFKQPNKEFNEMAFSYKNLTDNTFEVGVHVTNVCKYIQQNEFLDTLSVNRFFTFLLPNLNFSQNSTVQSDYLLSKALSNE-FSINLGKPTDVISFYFQ 1994
Y P + EK+ D C+L + AHSG I S K +I L NR+NCG AF GDIV++ KI P K TG+V+ V S KPIN I++C + +LMTP+ +T P I+VDN+H E K+ + LK+ QK++ +SF A+ + +L D+ N L SV D +TC+ F+V Y WD + +P G+VVGI E +I C++ + + + ++ K + S SD VF+ N + + A SY ++T +G+H+++V KYI + + RF T P + +L+ + LS + S+ P V+S +F+
Sbjct: 238 YTPDELEKM---DDLILCELKIIGAHSGIAIPIKTQSVKYEEIKLLNRRNCGYNAFDGDIVRV--------KINDP-----------KIPTGKVVDVYESYHKPINSIYVCKVNRDQGSLMTPLDSTFPKIHVDNQHGHRQYESEIQKREKSFLKDE---------QKSVVERGKESFKYADNLYYSLFDVSVNENKLHFQFKSVEKFDPHTCDNYFIVCYERWDPQYMYPYGKVVGILNGRDTLEENFELISSICNIESVNLTAQYEKEVQEIIGKVKLLNESEDYIPSDAVVFTIDSKNTKDIDDAISYHKEGNDTV-IGIHISDVTKYISSTHEIYYQAQRRFCTIYPP--------YKKPIHLIDERLSTDALSLIPNVPRAVVSVFFR 590 The following BLAST results are available for this feature:
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Helicase with zinc finger domain 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002317 ID=SMED30002317|Name=Helicase with zinc finger domain 2|organism=Schmidtea mediterranea sexual|type=transcript|length=5908bpback to top protein sequence of SMED30002317-orf-1 >SMED30002317-orf-1 ID=SMED30002317-orf-1|Name=SMED30002317-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1865bp MNVNNKDDEWHTISRNKKDKIKNDSINNKSTFQIMRPNDCIVNNDNNLDDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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