Exportin-5

Overview
NameExportin-5
Smed IDSMED30002210
Length (bp)3375
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Exportin-5 (SMED30002210) t-SNE clustered cells

Violin plots show distribution of expression levels for Exportin-5 (SMED30002210) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Exportin-5 (SMED30002210) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Exportin-5 (SMED30002210) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30002210

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
anterior region of the whole animalSMED30002210SMESG000001611.1 dd_Smed_v4_12042_0_1dd_Smed_v4PMID:27063937
Scimone et al., 2016		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
X1 cellSMED30002210SMESG000001611.1 SmedASXL_015894SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30002210SMESG000001611.1 SmedASXL_015894SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Exportin-5 vs. Ensembl Human
Match: XPO5 (exportin 5 [Source:HGNC Symbol;Acc:HGNC:17675])

HSP 1 Score: 116.701 bits (291), Expect = 1.093e-25
Identity = 140/600 (23.33%), Postives = 256/600 (42.67%), Query Frame = 2 
Query: 1370 GKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIF--IWFH-IHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLL-----------SKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQT--NPNE-----QLPVMLMILNNVC--------RSITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            G   +  +L FD  D  I+      +  L PFV  + E + +   K+F  + F  + ES  P+       R V ++    I+++ RDY  L+            + L   +L+    KC        ++EA+ +      NY   +Q++        + S+ LSQ    V  + ++ + Y+  +  +      P  +     N  +  FC+Y   G+  R    T+         V   +     I   P  E I  LL +LL +IR  N +++  ++   AE F+   ++ D  K  I+   P   +  N+S  F +  +   + F S L+E+ + IL K   +     Y +++    ++   F +L+++P+++L P+++ FV P V  CP + +E ++S  + P   Y   RL ++W  I   S++  + +  ++N +       E++EEQ++RMLT+   +LI  T    S  G D           + +  T   P+       L   LM   +VC         S+ WKD+  C +  S L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  531 GIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAV---RNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKC-------ALMEALVLISNQFKNY--ERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKS----CDPGLEDPCGLNRARMSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILG-LPQPLLELNDSPVF-KTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPES-----QEMLEEQLVRMLTREVMDLI--TVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLS-GTLLADAVTWLFTSVLKGLQM--HGQHDGCMASLVHLAFQIYE 1102
[Close]
BLAST of Exportin-5 vs. Ensembl Human
Match: XPO5 (exportin 5 [Source:HGNC Symbol;Acc:HGNC:17675])

HSP 1 Score: 60.077 bits (144), Expect = 5.347e-9
Identity = 57/226 (25.22%), Postives = 97/226 (42.92%), Query Frame = 2 
Query: 2447 PFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLK----------FGVIVDRLF---QTNPNE-----QLPVMLMILNNVCR--------SITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            P V  CP + +E ++S  + P   Y   RL ++W  I   S++  + +  ++N +       E++EEQ++RMLT+   +LI  T    S  G D                + +I D      +  P+       L   LM   +VC         S+ WKD+  C +  S L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:    2 PLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPES-----QEMLEEQLVRMLTREVMDLI--TVCCVSKKGADHSSAPPADGDGWSLTFYSLITDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLS-GTLLADAVTWLFTSVLKGLQMH--GQHDGCMASLVHLAFQIYE 217
[Close]
BLAST of Exportin-5 vs. Ensembl Fly
Match: Ranbp21 (gene:FBgn0031051 transcript:FBtr0340614)

HSP 1 Score: 82.8037 bits (203), Expect = 1.437e-15
Identity = 92/463 (19.87%), Postives = 193/463 (41.68%), Query Frame = 2 
Query: 2048 PLYEHIRALLPSLLKIIRAINQVWSSSVIHA---EFSSLKEISDYYKDTIIN-----NKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQ-----------------------LPVMLM--------ILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMA-----GXXXXXXXXXXXXXXXQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPST 3304
            P  +HI  LL  +L ++R +N++++   + A    +  +  + ++ K  ++        P +    +   +F ++     + F+  + E  + ++     +    LY +     +++  VFS +D +P+++L P+I+ F  PFV  CP   ++ V+            +RL  +W  I +   + E    D + ND       E++E+Q+ R LT+ + +++++   +G   G D V     G   +       NE+                       L   L+        +L  + ++I W D  C  K   +  P++  + +  L++ +  +  F  ++  + +   G     +  L+ LGV  Y + +       +  +  +   +   I  F  K+A     G    + K+++ +KL    +  S+N+LF  EV I +LPP ++ H K  G M +T
Sbjct:  781 PATKHIVPLLSHVLSLMRVLNELFAPEALQALSEGYRGIHGMMEHEKKLLMGICALPTDPLDTTIRSEPTAFEKM-----QTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPIIRVFFKPFVYSCPPSFYDSVLVPLFAHLAPLMCERLTRRWIYIAS---LYESGQLDGEVND-----TQEVLEDQLNRTLTREYLDVLKIAL-VGGQIGADHVAA---GANANSNSVAMENEEHSMDSAPQSRAIQSALLSDIISDLGGKLLRNGLIGNYVLMTLLKAIAWNDGMCSMKAVNIAAPVMRFLAAEKLMDENKAVTAFTAVLQGMQVH--GQHEANQSGLVTLGVQFY-ELLRPQFPILSEVLQHIPSVNAADIQKFDEKIAVAPVKGNKVDRAKKDIFKKLTAQLVGRSVNQLFRHEVQIANLPP-MQSH-KAKGSMGTT 1221
[Close]
BLAST of Exportin-5 vs. Ensembl Fly
Match: Ranbp21 (gene:FBgn0031051 transcript:FBtr0074759)

HSP 1 Score: 82.8037 bits (203), Expect = 1.437e-15
Identity = 92/463 (19.87%), Postives = 193/463 (41.68%), Query Frame = 2 
Query: 2048 PLYEHIRALLPSLLKIIRAINQVWSSSVIHA---EFSSLKEISDYYKDTIIN-----NKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQ-----------------------LPVMLM--------ILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMA-----GXXXXXXXXXXXXXXXQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPST 3304
            P  +HI  LL  +L ++R +N++++   + A    +  +  + ++ K  ++        P +    +   +F ++     + F+  + E  + ++     +    LY +     +++  VFS +D +P+++L P+I+ F  PFV  CP   ++ V+            +RL  +W  I +   + E    D + ND       E++E+Q+ R LT+ + +++++   +G   G D V     G   +       NE+                       L   L+        +L  + ++I W D  C  K   +  P++  + +  L++ +  +  F  ++  + +   G     +  L+ LGV  Y + +       +  +  +   +   I  F  K+A     G    + K+++ +KL    +  S+N+LF  EV I +LPP ++ H K  G M +T
Sbjct:  781 PATKHIVPLLSHVLSLMRVLNELFAPEALQALSEGYRGIHGMMEHEKKLLMGICALPTDPLDTTIRSEPTAFEKM-----QTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPIIRVFFKPFVYSCPPSFYDSVLVPLFAHLAPLMCERLTRRWIYIAS---LYESGQLDGEVND-----TQEVLEDQLNRTLTREYLDVLKIAL-VGGQIGADHVAA---GANANSNSVAMENEEHSMDSAPQSRAIQSALLSDIISDLGGKLLRNGLIGNYVLMTLLKAIAWNDGMCSMKAVNIAAPVMRFLAAEKLMDENKAVTAFTAVLQGMQVH--GQHEANQSGLVTLGVQFY-ELLRPQFPILSEVLQHIPSVNAADIQKFDEKIAVAPVKGNKVDRAKKDIFKKLTAQLVGRSVNQLFRHEVQIANLPP-MQSH-KAKGSMGTT 1221
[Close]
BLAST of Exportin-5 vs. Ensembl Zebrafish
Match: XPO5 (si:ch211-233m11.2 [Source:ZFIN;Acc:ZDB-GENE-081107-24])

HSP 1 Score: 53.1434 bits (126), Expect = 1.964e-6
Identity = 75/378 (19.84%), Postives = 155/378 (41.01%), Query Frame = 2 
Query: 1367 KGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYH-FLLS---------KSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRI-------SSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVW---SSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLI 2431
            +G   +   + F+  D  I+     ++  L P +  +   + + L KIF         + K       + V ++    I+RI RDY  F+L          K LF   L+  Q       E   ++EA+ +      +Y   +Q+         + ++ LS+   SV  +  + + ++  +     ++     D+    N  +   C++   G+  R         ++    VV T S  T  +   P  E ++ALLP+LL +IR  N ++   + + +   F+ + +I+D  K+ ++    ++ +  +   +  + +    + F S L E+ + +L           Y I+   + ++   F+ LDS+P+ +L PLI
Sbjct:  532 EGMALLQIAVNFETRDPLILSCVLTIVSTLFPILTHRPHFLPQVLFKIFSAITFELVDERKAPRTRAVKNVRRHACSSIIRICRDYSDFMLPCFDLMYEHVKRLFSDELLLTQ------LEKCALMEALILISNQFKDY--KKQKAFLEELMAPVTALWLSEEMRSVLWDPATFLTFVGADQEISDSD----TDEQMGINRSRISLCVHTILGVVKRARWPADADQAKAGGFVVRTASDGT-PVYRNPCAEALQALLPNLLALIRTNNSLFLPENITRLSKTFARVYDITDMEKNCVLG--ISQVVLDSYEAAVYKNFAERMQGFFSSLFENCYHVLGNVGPCLQQDFYGIEGLAEQIVGSAFNHLDSVPDHRLRPLI 894
[Close]
BLAST of Exportin-5 vs. Ensembl Xenopus
Match: hdac1 (histone deacetylase 1 [Source:Xenbase;Acc:XB-GENE-479583])

HSP 1 Score: 88.5817 bits (218), Expect = 4.448e-17
Identity = 68/303 (22.44%), Postives = 131/303 (43.23%), Query Frame = 2 
Query: 2237 FAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLI-------KSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIV-------DRLFQTNPNEQLPVMLMILNNVCRS---------------ITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIA 3055
            FA L+ N C+            IL  C  +     Y + +    ++  VF++ D++P+++L  ++         +  P +  CP +++E ++   + P I Y +QRL ++W +I   +V+ E+ D+ E++++     C E++EEQ++R LT+   +LI  +  I     D    G + G          + +  T+     P+ L  L     +               + WKD+  C K  S L  P++ +V S   L  D  + +F  ++C L   + G     K  L+ L    Y+  ++
Sbjct:  754 FASLFDNCCQ------------ILGHCGPSMPHEFYSVPDLASRLLSSVFTNADNVPDYRLRLILHILWFSPTEWHTPLILSCPAEKYESLVCPILGPLIIYLYQRLSQKWLSINQRTVVSEE-DYTEEDSE-----CQEVLEEQLVRQLTREVVDLIG-SCCIARKSNDFCASGAEVGHSAGQADGDEEEMMTTDAGAPGPIELTELGQFLLANEEISTSLLVISFSPLVWKDTMACQKAASHLCWPLLKQVMSASPLPADAALCVFSNILCGLQ--THGQHESCKFPLVQLSFQTYEALVS 1035
[Close]
BLAST of Exportin-5 vs. Ensembl Mouse
Match: Xpo5 (exportin 5 [Source:MGI Symbol;Acc:MGI:1913789])

HSP 1 Score: 106.686 bits (265), Expect = 1.071e-22
Identity = 137/643 (21.31%), Postives = 263/643 (40.90%), Query Frame = 2 
Query: 1229 TDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLL-----------SKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLF-QTNPNE-----QLPVMLMILNNVC--------RSITWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            + S +Q EA  FF   V++ + R   K             P   V  G   +  +L F+  D  ++      +  L PFV  +   + +   K+F +       + K       R V ++    I ++ RDY  L+            + L   +L+    KC        ++EA+ +      +Y   +Q++        + ++ LS+       + +S + Y+     A +    P  +     N  +  FC+Y   G+  R S  ++         V   +P    I   P  E I  LL +LL ++R  N +++  ++   AE F+   +I +  K  I+     + +   N     +  +   + F   L+E+ + IL K   +     Y +++    ++   F +L+++P+F+L  +++ FV P V  CP + +E ++S  + P   Y   RL ++W  I   S++  + +  E N +       E++EEQ++RMLT+   +LI +   +     D +      G   + +  +  P+       L   LM   +VC         S+TWKD+  C + +  L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  497 SPSYVQWEAMTFFLESVINQMFRTLDKE----------ELP---VSDGIELLQLVLNFEIKDPLVLSCVLTNVSALFPFVTYKPAFLPQVFSKLFSFVTFESVGESKAPRTRAVRNVRRHACSSINKMCRDYPDLVLPNFDMLYSHVKQLLSNELLLTQMEKCA-------LMEALVLVSNQFKDY--ERQKLFLEELMAPVVNIWLSEEMCRALSDIDSFIAYVG----ADLKSCDPAVEDPCGLNRARMSFCVYSILGVMRRTSWPSDLEEAKAGGFVVGYTPSGNPIFRNPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEPFTKALDIVESEKTAILGL--PQPLLEFNDHPVYRTTLERMQRFFGILYENCYHILGKAGPSMQQDFYTVEDLASQLLGSAFVNLNNIPDFRLRSMLRVFVKPLVLFCPSEHYETLISPILGPLFTYLHMRLSQKWHVINQRSILCGEDEIAEDNPES-----QEMLEEQLVRMLTREAMDLI-MACCVSKKTADHTAAPTADGDDEEMMATEVAPSSVVELTDLGKCLMKHEDVCTALLITAFNSLTWKDTLSCQRATTQLCWPLLKQVMS-GTLLADAVTWLFTSVLKGLQM--HGQHDGCMASLVHLAFQIYE 1102
[Close]
BLAST of Exportin-5 vs. UniProt/SwissProt
Match: sp|Q9HAV4|XPO5_HUMAN (Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 5.247e-25
Identity = 140/600 (23.33%), Postives = 256/600 (42.67%), Query Frame = 2 
Query: 1370 GKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIF--IWFH-IHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLL-----------SKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQT--NPNE-----QLPVMLMILNNVC--------RSITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            G   +  +L FD  D  I+      +  L PFV  + E + +   K+F  + F  + ES  P+       R V ++    I+++ RDY  L+            + L   +L+    KC        ++EA+ +      NY   +Q++        + S+ LSQ    V  + ++ + Y+  +  +      P  +     N  +  FC+Y   G+  R    T+         V   +     I   P  E I  LL +LL +IR  N +++  ++   AE F+   ++ D  K  I+   P   +  N+S  F +  +   + F S L+E+ + IL K   +     Y +++    ++   F +L+++P+++L P+++ FV P V  CP + +E ++S  + P   Y   RL ++W  I   S++  + +  ++N +       E++EEQ++RMLT+   +LI  T    S  G D           + +  T   P+       L   LM   +VC         S+ WKD+  C +  S L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  531 GIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAV---RNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKC-------ALMEALVLISNQFKNY--ERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKS----CDPGLEDPCGLNRARMSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILG-LPQPLLELNDSPVF-KTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPES-----QEMLEEQLVRMLTREVMDLI--TVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLS-GTLLADAVTWLFTSVLKGLQM--HGQHDGCMASLVHLAFQIYE 1102
[Close]
BLAST of Exportin-5 vs. UniProt/SwissProt
Match: sp|Q924C1|XPO5_MOUSE (Exportin-5 OS=Mus musculus OX=10090 GN=Xpo5 PE=1 SV=1)

HSP 1 Score: 106.686 bits (265), Expect = 7.495e-22
Identity = 137/643 (21.31%), Postives = 263/643 (40.90%), Query Frame = 2 
Query: 1229 TDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLL-----------SKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLF-QTNPNE-----QLPVMLMILNNVC--------RSITWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            + S +Q EA  FF   V++ + R   K             P   V  G   +  +L F+  D  ++      +  L PFV  +   + +   K+F +       + K       R V ++    I ++ RDY  L+            + L   +L+    KC        ++EA+ +      +Y   +Q++        + ++ LS+       + +S + Y+     A +    P  +     N  +  FC+Y   G+  R S  ++         V   +P    I   P  E I  LL +LL ++R  N +++  ++   AE F+   +I +  K  I+     + +   N     +  +   + F   L+E+ + IL K   +     Y +++    ++   F +L+++P+F+L  +++ FV P V  CP + +E ++S  + P   Y   RL ++W  I   S++  + +  E N +       E++EEQ++RMLT+   +LI +   +     D +      G   + +  +  P+       L   LM   +VC         S+TWKD+  C + +  L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  497 SPSYVQWEAMTFFLESVINQMFRTLDKE----------ELP---VSDGIELLQLVLNFEIKDPLVLSCVLTNVSALFPFVTYKPAFLPQVFSKLFSFVTFESVGESKAPRTRAVRNVRRHACSSINKMCRDYPDLVLPNFDMLYSHVKQLLSNELLLTQMEKCA-------LMEALVLVSNQFKDY--ERQKLFLEELMAPVVNIWLSEEMCRALSDIDSFIAYVG----ADLKSCDPAVEDPCGLNRARMSFCVYSILGVMRRTSWPSDLEEAKAGGFVVGYTPSGNPIFRNPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEPFTKALDIVESEKTAILGL--PQPLLEFNDHPVYRTTLERMQRFFGILYENCYHILGKAGPSMQQDFYTVEDLASQLLGSAFVNLNNIPDFRLRSMLRVFVKPLVLFCPSEHYETLISPILGPLFTYLHMRLSQKWHVINQRSILCGEDEIAEDNPES-----QEMLEEQLVRMLTREAMDLI-MACCVSKKTADHTAAPTADGDDEEMMATEVAPSSVVELTDLGKCLMKHEDVCTALLITAFNSLTWKDTLSCQRATTQLCWPLLKQVMS-GTLLADAVTWLFTSVLKGLQM--HGQHDGCMASLVHLAFQIYE 1102
[Close]
BLAST of Exportin-5 vs. UniProt/SwissProt
Match: sp|Q0WP44|HASTY_ARATH (Protein HASTY 1 OS=Arabidopsis thaliana OX=3702 GN=HST1 PE=1 SV=1)

HSP 1 Score: 57.3806 bits (137), Expect = 8.943e-7
Identity = 76/364 (20.88%), Postives = 145/364 (39.84%), Query Frame = 2 
Query: 2006 VNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHA---EFSSLKEISDYYKDTII---NNKPAEKIHPNNSQSF-------AQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFG------DDSVKGLKFGVIVD-RLFQTNPN-----EQLPVMLMILNNVCRSITWKDSFCCAKLS------LLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEI 3004
            +NT S  T +  S P+  H+  +LP LLK++R ++ +WS SV      E  +   ++D  + +++   N K ++ +      SF       A+   +  RN++  + +  + +L        G  ++       V   +  +L S+    +   I +F+   V  CP D +E  + + + P   +  Q L   W  +  +        F  Q+    S++  E++EE++LR LT+    L     + G N G         V  +    + D   F++N           V L  L     + TW D     K+       +L+  + N V  R  ++ D+   + + L    N  +S + + I
Sbjct:  743 LNTTSATTPA--SHPMAHHLSWMLPPLLKLLRVLHSLWSPSVFQTLPPEMRAAMTMTDAERYSLLGEANPKLSKGVSVYADGSFEGTKEGQAEASESDIRNWLKGIRDCGYNVLGLS--TTIGETFFKCLDANYVAMALMENLQSMEFRHIRLFIHTFITYIVKSCPADMWESWLGVLLHPLFIHCQQALSSAWPGLLQEGRAKVPDLFGIQS---GSDMKLEVMEEKLLRDLTREIATLFSTMASPGLNTGVPVLEHSGHVGRVDMSTLTDLHAFRSNSMVGFLLNHKSVALPALQICLETFTWTDGEATTKVCYFCGVVVLLAKLTNNVELREFVSKDMFSAVIRGLGMESNAINSPDLVNI 1099
[Close]
BLAST of Exportin-5 vs. TrEMBL
Match: A0A1S3WKN7 (exportin-5 isoform X1 OS=Erinaceus europaeus OX=9365 GN=XPO5 PE=4 SV=1)

HSP 1 Score: 148.673 bits (374), Expect = 6.892e-34
Identity = 241/1048 (23.00%), Postives = 432/1048 (41.22%), Query Frame = 2 
Query:  137 ESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEIL----------KSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETML---ERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEK-FRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIY---SMKRTIRD--PSNVDH---EY-LLNLIEQKDEENYVNRIRY---EASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKM---------QLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIF--IWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKS-----------LFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTI-ETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRL--TFTIGSNFGDDSVKGLKFGVIVDRLFQT--NPN-----EQLPVMLMILNNVC--------RSITWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            E E  I+ ++++ V+  I+ E PQ+ ++++++L  L   G     LV+ I   L+E +    ++P +R++++   LT+N + I  F L  L          K+ N+ E  +       V  + + AG+I + S+  +  +   +L     + N     LE  E +L    RK ++ED+  ++ +L  + +  Y     I +  Q A      EK + +L+++  +L  +GN         S  +    F K++ S    T +P + L       W   F       R  + SR   LL ++  Y   SM   +R   PS  D    EY   +    +D  ++ N  R    E  R    L    +  + T  L    S  +DI      + +S +         Q EA   F   V++ + R   K             P +    G   +  +L FD  D  I+      +  L PFV  + E + +   K+F  + F I E  + K       R V ++    I+++ RDY  L+  S           L + +L+    KC        ++EA+ +      NY   +Q++        + ++ LS+    V  + ++ + ++     A      P  +     N  +  FC+Y   G+  R S  T+         V   SP    I   P  E I  LL +LL +IR  N +++  V+   AE FS   ++ +  K  I+   P   +  N+S  +  + +   + F + L+E+ + IL K   +     Y ++     ++   F +L+++P+F+L  L++ FV P V     + +E +M+  + P   Y   RL ++W  I + + V  ED   DE     N E   E++EEQ++RMLT+   +LI +      G++ G  +       +  D +  T   P+       L   LM   +VC         S+TWKD+  C + +  L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  107 EEENHIKDVLSRIVVEMIKREWPQHWNDMLVELDTLSKQGETQTELVMFILLRLAEDIVTFQRLPAQRRRDIQQTLTQNMDKIFSFLLNTLQENVNKYRQVKTDNSQESTAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLLEILCLLLNEQELQLEAAECLLIAVSRKGKLEDRKPLM-VLFGDVAMHY-----ILSAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGVDSDVNTPANFGKYLESFLAFTTHPSQFLRSSTQMTWGALF-------RHEILSRDPLLLAIIPKYLRVSMTNLVRMGFPSKTDSPSCEYSRFDFDSDEDFNSFFNSSRAQQGEVMRLACRLDPKTSFQMATEWLTYQLSTPIDIGSMNSGTGESNLCSMFSPSFVQWEAMTLFLESVVNQMFRTVDKE----------ELPIN---DGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPEFLAQVFSKLFSSVTFEIAE--ENKVPRTRAVRNVRRHACSSIIKMCRDYPQLVLPSFDTLYNHVKQLLSDELLLTQMEKC-------ALMEALVLVSNQFKNY--ERQKVFIEELMAPVANIWLSEDMHRVLSDVDAFITFVG----ADRKNCDPGLEDPCGLNRARMSFCVYSILGVVKRTSWPTDLEEAKAGGFVVGYSPSGNPIFRNPCTEQILKLLDNLLALIRTYNTLYAPEVLAKMAEPFSKTLDMLESEKSAIL-GLPQPLLELNDSPVYKTI-LERMQRFFATLYENCFHILGKAGPSMQQDFYTVEHLATQLLNSAFVNLNNIPDFRLRSLLRVFVKPLVLFSSPEHYESLMAPILGPLFTYLHMRLSQKWQVINQRNMVCGEDEAADE-----NLE-SQEMLEEQLVRMLTREAMDLITVCCVSKKGADHGTTTSAPPTADIDDDEMMATEVTPSTMTELTDLGKSLMKHEDVCTALLITAFNSLTWKDTLSCQRTTTQLCWPLLKQVLS-GTLLADAVTWLFTSVLRGLQM--HGQHDGCMASLVHLAFQIYE 1102

HSP 2 Score: 27.7202 bits (60), Expect = 6.892e-34
Identity = 12/38 (31.58%), Postives = 24/38 (63.16%), Query Frame = 1 
Query:   13 VKIFGLKCLENFILYKWNTA---DKITTRGYLIEIIKE 117
            V+ FGL+ LE+ + Y+WN     +K+  +  ++E I++
Sbjct:   63 VRHFGLQILEHVVKYRWNNMSQLEKVYLKNSVMEFIEK 100
[Close]
BLAST of Exportin-5 vs. TrEMBL
Match: A0A1S3A768 (exportin-5 isoform X2 OS=Erinaceus europaeus OX=9365 GN=XPO5 PE=4 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 7.194e-33
Identity = 243/1053 (23.08%), Postives = 434/1053 (41.22%), Query Frame = 2 
Query:  137 ESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEIL----------KSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETML---ERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEK-FRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIY---SMKRTIRD--PSNVDH---EY-LLNLIEQKDEENYVNRIRY---EASRAISSLTEHFTQGIITLCLDMVYSAILDIQQ---------KGE-----LSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIF--IWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKS-----------LFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTI-ETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRL--TFTIGSNFGDDSVKGLKFGVIVDRLFQT--NPN-----EQLPVMLMILNNVC--------RSITWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            E E  I+ ++++ V+  I+ E PQ+ ++++++L  L   G     LV+ I   L+E +    ++P +R++++   LT+N + I  F L  L          K+ N+ E  +       V  + + AG+I + S+  +  +   +L     + N     LE  E +L    RK ++ED+  ++ +L  + +  Y     I +  Q A      EK + +L+++  +L  +GN         S  +    F K++ S    T +P + L       W   F       R  + SR   LL ++  Y   SM   +R   PS  D    EY   +    +D  ++ N  R    E  R    L    +  + T  L    S  +DI            GE     + + S +Q EA   F   V++ + R   K             P +    G   +  +L FD  D  I+      +  L PFV  + E + +   K+F  + F I E  + K       R V ++    I+++ RDY  L+  S           L + +L+    KC        ++EA+ +      NY   +Q++        + ++ LS+    V  + ++ + ++     A      P  +     N  +  FC+Y   G+  R S  T+         V   SP    I   P  E I  LL +LL +IR  N +++  V+   AE FS   ++ +  K  I+   P   +  N+S  +  + +   + F + L+E+ + IL K   +     Y ++     ++   F +L+++P+F+L  L++ FV P V     + +E +M+  + P   Y   RL ++W  I + + V  ED   DE     N E   E++EEQ++RMLT+   +LI +      G++ G  +       +  D +  T   P+       L   LM   +VC         S+TWKD+  C + +  L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  107 EEENHIKDVLSRIVVEMIKREWPQHWNDMLVELDTLSKQGETQTELVMFILLRLAEDIVTFQRLPAQRRRDIQQTLTQNMDKIFSFLLNTLQENVNKYRQVKTDNSQESTAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLLEILCLLLNEQELQLEAAECLLIAVSRKGKLEDRKPLM-VLFGDVAMHY-----ILSAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGVDSDVNTPANFGKYLESFLAFTTHPSQFLRSSTQMTWGALF-------RHEILSRDPLLLAIIPKYLRVSMTNLVRMGFPSKTDSPSCEYSRFDFDSDEDFNSFFNSSRAQQGEVMRLACRLDPKTSFQMATEWLTYQLSTPIDIGSMNSCSFTAGTGESNLCSMFSPSFVQWEAMTLFLESVVNQMFRTVDKE----------ELPIN---DGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPEFLAQVFSKLFSSVTFEIAE--ENKVPRTRAVRNVRRHACSSIIKMCRDYPQLVLPSFDTLYNHVKQLLSDELLLTQMEKC-------ALMEALVLVSNQFKNY--ERQKVFIEELMAPVANIWLSEDMHRVLSDVDAFITFVG----ADRKNCDPGLEDPCGLNRARMSFCVYSILGVVKRTSWPTDLEEAKAGGFVVGYSPSGNPIFRNPCTEQILKLLDNLLALIRTYNTLYAPEVLAKMAEPFSKTLDMLESEKSAIL-GLPQPLLELNDSPVYKTI-LERMQRFFATLYENCFHILGKAGPSMQQDFYTVEHLATQLLNSAFVNLNNIPDFRLRSLLRVFVKPLVLFSSPEHYESLMAPILGPLFTYLHMRLSQKWQVINQRNMVCGEDEAADE-----NLE-SQEMLEEQLVRMLTREAMDLITVCCVSKKGADHGTTTSAPPTADIDDDEMMATEVTPSTMTELTDLGKSLMKHEDVCTALLITAFNSLTWKDTLSCQRTTTQLCWPLLKQVLS-GTLLADAVTWLFTSVLRGLQM--HGQHDGCMASLVHLAFQIYE 1107

HSP 2 Score: 27.7202 bits (60), Expect = 7.194e-33
Identity = 12/38 (31.58%), Postives = 24/38 (63.16%), Query Frame = 1 
Query:   13 VKIFGLKCLENFILYKWNTA---DKITTRGYLIEIIKE 117
            V+ FGL+ LE+ + Y+WN     +K+  +  ++E I++
Sbjct:   63 VRHFGLQILEHVVKYRWNNMSQLEKVYLKNSVMEFIEK 100
[Close]
BLAST of Exportin-5 vs. TrEMBL
Match: A0A401RX14 (Uncharacterized protein OS=Chiloscyllium punctatum OX=137246 GN=chiPu_0001075 PE=4 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.108e-32
Identity = 236/1122 (21.03%), Postives = 459/1122 (40.91%), Query Frame = 2 
Query:  143 ERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEIL----------KSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSIL-IQCLNVNNCDYYILETIETML---ERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLL---PLLKIYSMKRTIRD--PSNVDH---EY-LLNLIEQKDEENYVNRIRYEASRAIS---SLTEHFTQGIITLCLDMVYSAILDIQ------QKGELS--TDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDI-VVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIF---IWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSK--SLFETILIYYQSKCQKL--YENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLY---GICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVI---HAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLY---VNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELI-------RLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCR--------SITWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD-------DFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGXXXXXXXXXXXXXXXQPYIRVSINKLFSQEVFIKDLPPLLK 3268
            E  I+  +++ V+  I+ E PQ   +++ ++  L   G     LV+ I   L E +     +P +R+K++   LT+N   +  F L+IL          K+    E  +      +V T+ + AG++ + +L  +  D   +L + C+ +   +   LE  E +L    RK ++ED+  +L  ++ +++  + +L   +T     +    ++ + +L+++  +L  +G      W       +   F+K++ +    T +P + L       W       C  LR    S+   LL   P L   +M   ++   PS  D    EY  ++    +D   + N  R +    I     L+      + +  L    +A++D+        KG  S  + S +Q +A  FF   VM  + R              T  P  + V  G   +  +L +   D  I+      +  L PF+     V+ + LEK+F    +  + ES  P+       + V ++    IL++ RD+  L+     +F   +   Q   ++L   E   ++E++ +      +Y   +Q+         + ++ LS+    V  +    ++Y+     A V    PI +     N  +   C+Y   G+  R    T+         V   +P    I      EH+  LL +LL +IR  N +W   ++      F+   ++ +  K+ I+         P    + A +Y   +   + F   L+++ + IL     +     + I  + +SVI   F +L+++P+++L P+++ FV P V  CP + +E V+   + P  +Y  QRL  +W  I    ++  ++   E+N +       E+++EQ+ R+LT+   +L+       +   +I  +  DD +     G  V     T+    L   L+   ++C+        +ITW D+  C + +L L  P++ +V S   L+ D   + F  ++  L +   G       +L+NL   +Y+       D      Q        LD+   +L+    +KM  K    + +++L       I   + + F +EV IK+LP L K
Sbjct:  109 EAYIKDALSRIVVEMIKREWPQQWPDMLNEMDKLTAMGETQTELVMLILLRLVEDVVTFQTIPAQRRKDIQHALTQNMMQLFSFLLDILQEHTQSYKQLKADTTQENKAKAHCRVAVATLNTLAGYVDWVALHHITADSCKLLEVLCMLLTEPELQ-LEAAECLLIAISRKGKLEDRKPLL--VLFSDAAMHCILSAAQTAHGAGL---VEQHYMFLKRLCQVLTALGGQLTALWGSDKDVGQPPNFNKYLQAFLAFTNHPSQYLRSSTQIAW-------CSFLRHEHVSKDPVLLEVIPQLLHATMANLLKVGFPSKSDSPSCEYSRVDFDNDEDFNAFFNSFRAQQGETIRLSCRLSPMTGFNMASEALQYQLTAVIDVGPTMSKTGKGLCSIFSPSFVQWDALTFFMESVMSQLFR--------------TMEPEQLPVADGIELLKAVLSYQTHDPLILSCILTAVSTLSPFLLHDATVLPQVLEKLFASATFEVVEESQAPRTRAV---KNVRRHACSSILKMCRDHPELIMPVFEMFYAHVKRLQQDERQLTQLEKCALMESLVLLSNQFKDY--ERQKAFLEELMAPVTNLWLSEEMQRVLSDPAMFLSYIG----ADVTPDDPIREDPAGINRSRISLCVYTILGVVKRARWPTDLEEAKAGGFVVGFTPSGSPIYRNACTEHVIKLLDNLLALIRTHNNLWLPEMLAQLSPHFTKAHDMLEVEKNAILGIP-----QPLLDHADAPVYKSVLERMQGFFCTLYDNCFHILGNAGPSMLQDFFDITNFAESVINSAFVNLENIPDYRLRPVLRVFVKPLVQSCPPEHYESVLCPILGPLFSYLLQRLSAKWVVINQRGLLEAESGAPEENPES-----QEMLDEQLTRLLTRESIDLMTVCCCVKKGPESISGDMDDDEMMNTSDGPHVGSEELTD----LGKCLLKSEDICKALLATAYSAITWSDTITCQRATLQLCWPLIKQVLS-ATLHSDAASWFFMSVLRGLQMH--GQHEGCLAALVNLAFMIYEALRPRYPDLKTVMQQVPQISGDALDQFDTKLLNPSSHKMGDKRRKDLFKKLLSGC----IGKPLGQKFKKEVHIKNLPTLFK 1173

HSP 2 Score: 24.6386 bits (52), Expect = 1.108e-32
Identity = 9/18 (50.00%), Postives = 14/18 (77.78%), Query Frame = 1 
Query:   13 VKIFGLKCLENFILYKWN 66
            V+ FGL+ LE+ I ++WN
Sbjct:   63 VRHFGLQILEHSIKFRWN 80
[Close]
BLAST of Exportin-5 vs. TrEMBL
Match: D3ZQE8 (Exportin 5 OS=Rattus norvegicus OX=10116 GN=Xpo5 PE=1 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 2.485e-30
Identity = 225/1051 (21.41%), Postives = 424/1051 (40.34%), Query Frame = 2 
Query:  137 ESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLE-----------SVKTIQSFAGWIKFESL-------CKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEK-FRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIY---SMKRTIRD--PSNVDH---EY-LLNLIEQKDEENYVNRIRY---EASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELST-------------DSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLL-----------SKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSET---------ENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIH--AE-FSSLKEISDYYKDTIIN-NKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIR---LTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNE--QLPVMLMILNNVC--------RSITWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYD 3043
            E E  I+ ++++ V+  I+ E PQ+  +++M+L  L   G   + LV+ I   L+E +     +P +R++++   LT+N E I+ F L  L+  N N++  +                S+  + + AG+I + SL       CKL + +  +L +          +L  +     RK ++ED+  ++ IL  + +  Y L     +  Q A      EK + +L+++  +L  +GN+        +     + F  ++ S    T +P + L       W   F       R  + SR   LL ++  Y   SM   ++   PS  D    EY   +    +D   + N  R    E  R +  L    +  +    L    SA +D       ST              S +Q EA  FF   V++ + R   K             P +   +G   +  +L F+  D  I+      +  L PFV  +   + +   K+F +       + K       R V ++    I ++ RDY  L+            + L   +L+    KC        ++EA+ +      +Y   +Q++        + ++ LS+       + ++ + Y+     A +    P A      N  +  FC+Y I   +   T             V   +P    +   P  E I  LL +LL ++R  N +++  ++   AE F+   +I +  K  I+   +P  +I   N     +  +   + F   L+E+ + IL K   +     Y +++    ++   F +L+++P+F+L  +++ FV P V  CP + +E ++S  + P   Y   RL ++W  I   SV+  + +  E N +       E++EEQ++RMLT+   +LI    ++     +    +  G    ++   +  ++  E   L   LM   +VC         S+TWKD+  C + +  L  P++ +V S G L  D V ++F  ++  L +   G       SL++L   +Y+
Sbjct:  107 EEENHIKDVLSRIVVEMIKREWPQHWPDMLMELDTLSRQGETQRELVMFILLRLAEDVVTFQTLPTQRRRDIQQTLTQNMERILNFLLSTLQE-NVNKYQQMKTDASQEAEAQANCRVSIAALNTLAGYIDWVSLNHITAENCKLVETLCLLLNEQELQLGAAECLLIAVS----RKGKLEDRKRLM-ILFGDVAMHYVL-----SAAQTADGGGLVEKHYLFLKRLCQVLCALGNLLCALLALDANIQTPVNFGMYLESFLAFTTHPSQFLRSSTHMTWGALF-------RHEVLSRDPSLLAVIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQHGEVVRCVCRLDPKTSFQMAAEWLKYQLSAAIDTGPVNSCSTAGTGEGGFCSIFSPSYVQWEAMTFFLESVINQMFRTLEKE----------ELPVN---EGIELLQLVLNFEMKDPLILSCVLTNVSALFPFVTYKPAFLPQVFSKLFSFVTFESVGESKAPRTRAVRNVRRHACSSINKMCRDYPDLVLPNFDMLYSHVKQLLSNELLLTQMEKCA-------LMEALVLVSNQFKDY--ERQKLFLEELMAPVVNIWLSEEMCRALSDIDAFIAYVG----ADLKSCDPAAQDPCGLNRARMSFCVYSILGVMRRTTWPSDLEEAKAGGFVVGYTPSGNPVFRNPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEPFTKALDIVESEKTAILGLPQPLLEI---NDHPVYRTILERMQRFFGILYENCYHILGKAGPSMQQDFYTVEDLATQLLGSAFVNLNNIPDFRLRSMLRVFVKPLVLFCPPEHYETLISPILGPLFTYLHMRLSQKWHVINQRSVLCGEDEIAEDNPES-----QEMLEEQLVRMLTREVMDLIMACCVSKKTAEHTATPTADGDDEEMMATEVAPSSVVELTDLGKCLMKHEDVCTALLITAFNSLTWKDTLSCQRATTQLCWPLLKQVMS-GTLLADAVTWLFTSVLKGLQM--HGQHDGCMASLVHLAFQIYE 1102

HSP 2 Score: 27.335 bits (59), Expect = 2.485e-30
Identity = 11/36 (30.56%), Postives = 24/36 (66.67%), Query Frame = 1 
Query:   13 VKIFGLKCLENFILYKWNTA---DKITTRGYLIEII 111
            V+ FGL+ LE+ + ++WN+    +K+  +  ++E+I
Sbjct:   63 VRHFGLQILEHVVKFRWNSMSRLEKVYLKNSVMELI 98
[Close]
BLAST of Exportin-5 vs. TrEMBL
Match: Q70DV0 (Exportin 5 OS=Xenopus tropicalis OX=8364 GN=xpo5 PE=2 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 2.326e-29
Identity = 235/1134 (20.72%), Postives = 463/1134 (40.83%), Query Frame = 2 
Query:  137 ESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSS------------NNNEWYSLI-IKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETML---ERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRY--LQKIMDLLLVMGNIFINCWMKFSQQSR---SICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTL-SSRANFLLP-LLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRY---EASRAISSLTEHFTQGIITLCLDMVYSAILDI----QQKGEL----STDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDY-----------HFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETE------NNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSF-------AQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELI-----------------RLTFTIGSNFGDD----SVKGLKFGVI-VDRLFQ-TNPNEQLPVMLMILNNVCRSITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGXXXXXXXXXXXXXXXQ---PYIRVSINKLFSQEVFIKDLPPLLKPHWKT 3283
            E E  I+ ++A+ V+   + E PQ+  +++ +L  L   G     LV+ I   L+E +     +P +R++++   +T+  + +  F L IL+ S            N+ +   +  + + S+KT+  +  W+    +  +AD+   + + C+ ++  +   LE  E +L    RK ++ED+  +L IL  +E+  Y L +      Q+A     +EK RY  L++I  L+  +G     C +  S   +      F+K++ ++   T +  + L    +  W   F+ +  +    L ++  +FL   ++ I  +    +D S       ++    +D   + N  R       RA   L  H    I    L    SA LD      Q G+     ++ S +Q EA  FFC CV   + R   K             P   V +G   +  +L ++  D  I+      L  L+PF+      V   L K+        S D K         V ++    ++++ RDY           H  ++  L E  L+    KC        ++EA+ +      +Y   +Q+++       + S  +S+     F   +  ++++  +      E         +  +    F L G+  R    T+         V   S     ++  P    +  +L SLL +IR +N ++   V       + ++ D +  ++       K+    SQS        A+  ++  + F + L ++   IL  C  +     Y + +    ++  VF++ D++P+++L  +++  V P +  CP +++E ++   + P I Y +QRL ++W +I   +V+ E+ D+ E++++     C E++EEQ++R LT+   +LI                  +  + G   GD+    + + +  G I +  L Q    NE++   L++++     + WKD+  C K  S L  P++ +V S   L  D  + +F  ++C L   + G     K  L+ L    Y+    +  +       + D   + L   F  K+        +++  E   +     I   + + F +EV I++LP L K   K+
Sbjct:  106 EEESHIKDMMARIVVEMAKREWPQHWPDLLNELDSLTRVGEAQTELVMFILLRLAEDVVTFQNLPTQRRRDIQTTMTQKMDVLFAFMLNILQQSVQQYQHLKTDPANSVKAQGMCRVAVASLKTLAGYIDWVAITHI--MADNCKLLGMLCVLLSEPELQ-LEAAECLLIAVSRKGKLEDRIPLL-ILFGDEAIEYILSVA-----QMADTETLEEK-RYILLKRICQLICTLGTQI--CALTQSPDLKVNVPGNFNKYLETLLSFTRHASQFLTSSTILTWGTIFRHEVLSRHPQLLAAIPDFLRSSMVSIVRVGFPSKDNSPSCKYSRMDYESDEDFNGFFNSFRALMGGVVRAACYLDPHTGFCIAKEWLQFQLSAPLDPGPHNAQPGDALCSPTSTSFLQWEAMTFFCECVTSQLFRVVPKE----------ELP---VAEGIGLLQQVLSYETMDPLILSFVLTNLSSLMPFITCLSSYVPPVLSKLLDAISFPLSGDMKVSKSRGEMNVRRHANSSLIKVCRDYPELVQPHFEQLHARVTALLGEEQLLTQMGKC-------ALMEALILASNQFKSY--DRQQVLLEELIGPLVSGCVSEKTQRAFSGPDEFISFVGADILMHQQEEEDRGAPS-RSQLSLCTFALLGMVKRSQWPTDPEEAKAGGFVIGYSASGAPLLRNPGARLLLKVLDSLLALIRTMNNLYLPEV-------MGKMGDTFCKSLNMLAMDRKLLMGTSQSAIEDCDLPAKTNLSRIQFFFASLFDNCCQILGHCGPSMPHEFYSVPDLASRLLSSVFTNADNVPDYRLRLILRVLVKPLILSCPAEKYESLVCPILGPLIIYLYQRLSQKWLSINQRTVVSEE-DYTEEDSE-----CQEVLEEQLVRQLTREVVDLIGSCCIARKSNDFCASGAEVGHSAGQADGDEEEMMTTEAVAPGPIELTELGQFLLANEEISTSLLVISF--SPLVWKDTMACQKAASHLCWPLLKQVMSASPLPADAALCVFSNILCGLQ--THGQHESCKFPLVQLSFQTYEALRPQYPELRGLMEQVPDVPRDSL-EQFDAKLLAPPQKVGEKKRREHFKKLIAGCIGKPLGEQFRKEVHIRNLPALFKKKTKS 1186

HSP 2 Score: 24.6386 bits (52), Expect = 2.326e-29
Identity = 9/18 (50.00%), Postives = 13/18 (72.22%), Query Frame = 1 
Query:   13 VKIFGLKCLENFILYKWN 66
            V+ FGL  LE+ I ++WN
Sbjct:   62 VRHFGLHVLEHVIKFRWN 79
[Close]
BLAST of Exportin-5 vs. Ensembl Sea Lamprey
Match: si:ch211-233m11.2 (exportin 5 [Source:HGNC Symbol;Acc:HGNC:17675])

HSP 1 Score: 72.4034 bits (176), Expect = 4.876e-13
Identity = 130/742 (17.52%), Postives = 293/742 (39.49%), Query Frame = 2 
Query: 1229 TDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFI---------WFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLS---KSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICC---------RISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIG---------SNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSI--------TWKDSFCCAKLSL-LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAG-----------------XXXXXXXXXXXXXXXQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTI 3286
            + S +Q +A   F  C M ++L+   K      K +        V +G   +  +L ++  D  ++      +  L+PF++     V   L+K+F          +F +  S   K+        V ++   C++RI RDY  LL    +S  E +L  ++ +     E    +E + I      NY   +Q     +    + ++ +         + +  + Y  L+     + +  IA      +  Q ++C+  +C           I        V  ++P    +      + +  +L ++L + R  +  W      A+ +   E++    ++  +N  A  +         +  +   ++FI+ +HES ++IL K         Y I    Q +++   S LD     +L  L+  F+  F+  CP + +  V+     P  +   Q+L   W  +   S+  + +  +++ +D       E++E+Q+ R++T+ + E++    ++           N  +D V  ++         +++   +L   L++    C++I        +W D+  C K +  L  P++ +      L+ + +++ F  ++  L +   G     +  L+NL   +Y++   + ++  N  ++ +   S   ++ ++ K+ G                 K + + +++  +KL+   I   I + F  E+ I+DLP L +   +T+
Sbjct:  497 SPSFIQWDALNTFMDCTMSHLLKALEK------KGLLAQS----VEEGIRLLNLVLSYEPGDPLVLSCALSCMSTLMPFLSHDSSAVPRVLDKLFSSVTFFYVLNFFQVPRSRSVKN--------VRRHACSCLVRICRDYPELLLPCFESFCEHLLRLHKMEGMTQLERVAFMECLVIISNKLCNY--DRQRAFLEQMLTTLMALWMEPDMQQALWSTDGFLAYFGLDKSIVPDGMEDIAGL----HRGQLVYCMNMMCMLVKRARWPESIEEAQAGGFVVGETPSGGPVYRNACSQFVCKMLENMLTLSRTFHSFWLPEQ-RAKLNKDYELAFECMESEKHNLLAIPLPLTEHHKKIRTPLERMQSFITTMHESCYIILGKVGSALGPDFYNIPNVAQLLLDSALSHLDISTEHRLRALLNFFLKLFIQTCPAESYNSVLIPICGPVFSVMLQKLSILWQNLVQRSMERKKSSEEDRADDA-----QEVLEDQLTRLVTREYLEILCACVSVKKSAELPTTMENMDEDEVMAIEAAPS-----ESDEISELGKGLIMNEEACQAILLSAFTALSWNDTPTCHKAATHLCWPVLKQAAQHS-LSPEAMVWCFTAVLRGLEVH--GQHDCSQSILVNLAFQIYENMRPRFTE-LNAIMNQIPNISADTLSMYEQKLIGDLMAPEGPPGPVGPNAVKQAERRRKDTFKKLIAGVIAKDIGQKFRNEIQIRDLPRLFQRQKRTV 1199
[Close]
BLAST of Exportin-5 vs. Ensembl Medaka
Match: si:ch211-233m11.2 (exportin 5 [Source:NCBI gene;Acc:101159607])

HSP 1 Score: 115.931 bits (289), Expect = 1.123e-26
Identity = 218/1122 (19.43%), Postives = 464/1122 (41.35%), Query Frame = 2 
Query:  137 ESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILK-------SSNNNEWYSLIIKLE---SVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETML---ERKTRVEDK--YLML------NILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRD--PSNVDH---EY-LLNLIEQKDEENYVNRIRYEASRAISSLT-----EHFTQGI------ITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDY-HFLLS-KSLFETIL--IYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVV-----QAIFCLYGICCRIS-SETENNVVNTKSPETI---SIISCPLYE-----HIRALLPSLLKIIRAINQVWSS---SVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFG---VIVDRLFQTNPNEQLPVM---LMILNNVC--------RSITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGXXXXXXXXXXXXXXXQPYIRVSINKL----FSQEVFIKDLPPLLK 3268
            E E  ++  +++ ++  I+ E PQ+  +++ ++  L + G +   +V+ I   L+E +     +P +R++++   LT+N +NI  F L +L               + L ++     +V T+ + AG+I + SL  +      +L     + +     LE  E +L    RK ++ED+  +++L        +++   +   L  ++ +   LA +   + ++ +L+++  +L  +G    +               K+  ++   T +P + L    L+ W   FK +  +    +   A   +  LK+ SM   ++   PS  D+   EY  ++    +D   +    R +    + + +     E F          I   +D+  +A    +    L + S +Q +A   F  CV+  +L+   +             P D   +    +  +L +D  D  I+      + +L+PF+  ++++V + L K+F         + K       + V ++    I+RI RDY  F+L    +F + +  +      Q   E   +VE++ +      ++   +Q+         + +   S+   SV  +   ++++        V     +A+QD   N+      +  FCL  +   +  +    +V   KS   +    +   P+Y         A +P+LL +IR  N ++     + +   F    E+ D  K+ +I   P   +   +S  + +  +   + F+  L+++ + +L     +     Y I    + +    F  LD +P+ +L  +I+ F+ P V  CP +  E ++   + P   Y  QRL  +W  I   +    D D +EQ     SE+  E++EEQ++R+LTK   +L+ L+  I     + +    + G   +++D +  ++  E L  +   LM   ++C         S++WKD+  C +  S++   ++ +V +  LL  + V + F  ++ AL +   G      ++L  L + +Y++   +  +     + + + +  Q +  F  K+      K   +  +   +  I  +I K     F +EV I++LP L K
Sbjct:  106 EEESHVKDALSRIIVEMIKREWPQHWPHMLKEMESLTSQGDVQTEVVMWILLRLAEDVITFQTLPSQRRRDIQQTLTQNMDNIFSFLLAVLHVHVESYHKVKGQPGHELQVRAHCRVAVATLNTLAGYIDWVSLTHITCGNCHLLETLCLLLSEPELQLEASECLLIALSRKGKLEDREPFMLLFDDVAIQCILSAAQSADGLSTSMNSSEPLAGD-VVERRYVFLKRLCQVLCALGVQLCSVVGSDVNVGVPANLSKYTEALLAFTTHPSQFLKSCTLATWGALFKHEVLSKDAVIVQMA---VKYLKV-SMTNLVKTGFPSQNDNPSSEYSRMDFHSDEDFHFFFYSFRGQQGDVLKTASRIVPLEAFQTAADWLHYQIACPIDLGQTASKSSKGSCSLMSPSVVQWDAMTVFMECVVSQILKTLPEE----------KLPVD---QSMELLQAVLNYDTKDPLILSCVLTTVSILLPFLVHRQQLVPQVLLKLFKAVTFEVDQENKGPRTKSVKNVRRHACSSIIRICRDYPQFILPCYDMFHSNVKKLLSSDASQTCMEKASLVESLVLISNKFQDF--EKQKAFLDELLAPVLAEWTSEEMRSVLWDPVKLLSF--------VGADQVVAEQDEHTNMASLNRGRMSFCLNAVLAVVKRARWPADVEEAKSGGFVVGYDLTGAPIYRNPCSAQFLAFMPNLLALIRTQNSLFMPENIARLSETFVGAHELMDTEKNIVIG-LPQLPMDFYDSPVY-RSNLERMQGFLGTLYDNCFSLLGSAGASLQKEFYTIDGLAELIAGSAFVSLDQVPDHRLRSIIRLFLKPLVVSCPPEYNESLLRPLLAPLFAYMMQRLSMKWQVISQRASADGD-DEEEQVVCQKSEVTQEMLEEQLVRLLTKEVLDLLNLS-CISKKVAEPAASKEENGEEDMMMDSVQTSSVPEDLTELGKCLMKHEDICMLLLTLSFTSLSWKDATNCNRTASMVCWTLLRQVAAGNLLP-EAVTWFFTSVLRALQVH--GQHEPCNLTLSQLAMVIYENLRPRYVELRGVMIQIPNINI-QALDQFDQKLMDPGVQKPTEKKRKDQFRKLIAGTIGKALCEQFRKEVHIRNLPSLFK 1191

HSP 2 Score: 25.409 bits (54), Expect = 1.123e-26
Identity = 9/18 (50.00%), Postives = 14/18 (77.78%), Query Frame = 1 
Query:   13 VKIFGLKCLENFILYKWN 66
            V+ FGL+ LE+ I ++WN
Sbjct:   62 VRHFGLQTLEHVIKFRWN 79
[Close]
BLAST of Exportin-5 vs. Ensembl Medaka
Match: si:ch211-233m11.2 (exportin 5 [Source:NCBI gene;Acc:101159607])

HSP 1 Score: 93.2041 bits (230), Expect = 1.047e-18
Identity = 135/665 (20.30%), Postives = 278/665 (41.80%), Query Frame = 2 
Query: 1163 ITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDY-HFLLS-KSLFETIL--IYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVV-----QAIFCLYGICCRIS-SETENNVVNTKSPETI---SIISCPLYE-----HIRALLPSLLKIIRAINQVWSS---SVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFG---VIVDRLFQTNPNEQLPVM---LMILNNVC--------RSITWKDSFCCAK-LSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDF 3049
            I   +D+  +A    +    L + S +Q +A   F  CV+  +L+   +             P D   +    +  +L +D  D  I+      + +L+PF+  ++++V + L K+F         + K       + V ++    I+RI RDY  F+L    +F + +  +      Q   E   +VE++ +      ++   +Q+         + +   S+   SV  +   ++++        V     +A+QD   N+      +  FCL  +   +  +    +V   KS   +    +   P+Y         A +P+LL +IR  N ++     + +   F    E+ D  K+ +I   P   +   +S  + +  +   + F+  L+++ + +L     +     Y I    + +    F  LD +P+ +L  +I+ F+ P V  CP +  E ++   + P   Y  QRL  +W  I   +    D D +EQ     SE+  E++EEQ++R+LTK   +L+ L+  I     + +    + G   +++D +  ++  E L  +   LM   ++C         S++WKD+  C +  S++   ++ +V +  LL  + V + F  ++ AL +   G      ++L  L + +Y++ 
Sbjct:  401 IACPIDLGQTASKSSKGSCSLMSPSVVQWDAMTVFMECVVSQILKTLPEE----------KLPVD---QSMELLQAVLNYDTKDPLILSCVLTTVSILLPFLVHRQQLVPQVLLKLFKAVTFEVDQENKGPRTKSVKNVRRHACSSIIRICRDYPQFILPCYDMFHSNVKKLLSSDASQTCMEKASLVESLVLISNKFQDF--EKQKAFLDELLAPVLAEWTSEEMRSVLWDPVKLLSF--------VGADQVVAEQDEHTNMASLNRGRMSFCLNAVLAVVKRARWPADVEEAKSGGFVVGYDLTGAPIYRNPCSAQFLAFMPNLLALIRTQNSLFMPENIARLSETFVGAHELMDTEKNIVIG-LPQLPMDFYDSPVY-RSNLERMQGFLGTLYDNCFSLLGSAGASLQKEFYTIDGLAELIAGSAFVSLDQVPDHRLRSIIRLFLKPLVVSCPPEYNESLLRPLLAPLFAYMMQRLSMKWQVISQRASADGD-DEEEQVVCQKSEVTQEMLEEQLVRLLTKEVLDLLNLS-CISKKVAEPAASKEENGEEDMMMDSVQTSSVPEDLTELGKCLMKHEDICMLLLTLSFTSLSWKDATNCNRTASMVCWTLLRQVAAGNLLP-EAVTWFFTSVLRALQVH--GQHEPCNLTLSQLAMVIYENL 1035
[Close]
BLAST of Exportin-5 vs. Planmine SMEST
Match: SMESG000001611.1 (SMESG000001611.1)

HSP 1 Score: 2166.73 bits (5613), Expect = 0.000e+0
Identity = 1077/1078 (99.91%), Postives = 1078/1078 (100.00%), Query Frame = 2 
Query:  116 NNFNVDNESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGXXXXXXXXXXXXXXXQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLCLEDLFKH 3349
            +NFNVDNESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGKLSLKVKREVLEKLLQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLCLEDLFKH
Sbjct:   90 SNFNVDNESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGKLSLKVKREVLEKLLQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLCLEDLFKH 1167

HSP 2 Score: 79.337 bits (194), Expect = 1.430e-14
Identity = 37/38 (97.37%), Postives = 38/38 (100.00%), Query Frame = 1 
Query:    4 SQQVKIFGLKCLENFILYKWNTADKITTRGYLIEIIKE 117
            +QQVKIFGLKCLENFILYKWNTADKITTRGYLIEIIKE
Sbjct:   51 NQQVKIFGLKCLENFILYKWNTADKITTRGYLIEIIKE 88
[Close]
BLAST of Exportin-5 vs. Planmine SMEST
Match: SMESG000001611.1 (SMESG000001611.1)

HSP 1 Score: 2166.73 bits (5613), Expect = 0.000e+0
Identity = 1077/1078 (99.91%), Postives = 1078/1078 (100.00%), Query Frame = 2 
Query:  116 NNFNVDNESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGXXXXXXXXXXXXXXXQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLCLEDLFKH 3349
            +NFNVDNESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGKLSLKVKREVLEKLLQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLCLEDLFKH
Sbjct:   95 SNFNVDNESERVIRWIIAKSVMYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQMPDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQSFAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVEDKYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLVMGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNGFKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQKDEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELSTDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKNTVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHIHESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQSKCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSCASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCRISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSSVIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFISRLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPLIKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMMEDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDDSVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSLLIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLGVSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGKLSLKVKREVLEKLLQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLCLEDLFKH 1172

HSP 2 Score: 79.337 bits (194), Expect = 1.409e-14
Identity = 37/38 (97.37%), Postives = 38/38 (100.00%), Query Frame = 1 
Query:    4 SQQVKIFGLKCLENFILYKWNTADKITTRGYLIEIIKE 117
            +QQVKIFGLKCLENFILYKWNTADKITTRGYLIEIIKE
Sbjct:   56 NQQVKIFGLKCLENFILYKWNTADKITTRGYLIEIIKE 93
The following BLAST results are available for this feature:
BLAST of Exportin-5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
XPO51.093e-2523.33exportin 5 [Source:HGNC Symbol;Acc:HGNC:17675][more]
XPO55.347e-925.22exportin 5 [Source:HGNC Symbol;Acc:HGNC:17675][more]
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BLAST of Exportin-5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Exportin-5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Ranbp211.437e-1519.87gene:FBgn0031051 transcript:FBtr0340614[more]
Ranbp211.437e-1519.87gene:FBgn0031051 transcript:FBtr0074759[more]
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BLAST of Exportin-5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
XPO51.964e-619.84si:ch211-233m11.2 [Source:ZFIN;Acc:ZDB-GENE-081107... [more]
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BLAST of Exportin-5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
hdac14.448e-1722.44histone deacetylase 1 [Source:Xenbase;Acc:XB-GENE-... [more]
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BLAST of Exportin-5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Xpo51.071e-2221.31exportin 5 [Source:MGI Symbol;Acc:MGI:1913789][more]
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BLAST of Exportin-5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q9HAV4|XPO5_HUMAN5.247e-2523.33Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV... [more]
sp|Q924C1|XPO5_MOUSE7.495e-2221.31Exportin-5 OS=Mus musculus OX=10090 GN=Xpo5 PE=1 S... [more]
sp|Q0WP44|HASTY_ARATH8.943e-720.88Protein HASTY 1 OS=Arabidopsis thaliana OX=3702 GN... [more]
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BLAST of Exportin-5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3WKN76.892e-3423.00exportin-5 isoform X1 OS=Erinaceus europaeus OX=93... [more]
A0A1S3A7687.194e-3323.08exportin-5 isoform X2 OS=Erinaceus europaeus OX=93... [more]
A0A401RX141.108e-3221.03Uncharacterized protein OS=Chiloscyllium punctatum... [more]
D3ZQE82.485e-3021.41Exportin 5 OS=Rattus norvegicus OX=10116 GN=Xpo5 P... [more]
Q70DV02.326e-2920.72Exportin 5 OS=Xenopus tropicalis OX=8364 GN=xpo5 P... [more]
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BLAST of Exportin-5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Exportin-5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
si:ch211-233m11.24.876e-1317.52exportin 5 [Source:HGNC Symbol;Acc:HGNC:17675][more]
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BLAST of Exportin-5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Exportin-5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Exportin-5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
si:ch211-233m11.21.123e-2619.43exportin 5 [Source:NCBI gene;Acc:101159607][more]
si:ch211-233m11.21.047e-1820.30exportin 5 [Source:NCBI gene;Acc:101159607][more]
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BLAST of Exportin-5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000001611.11.430e-1499.91SMESG000001611.1[more]
SMESG000001611.11.409e-1499.91SMESG000001611.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002210 ID=SMED30002210|Name=Exportin-5|organism=Schmidtea mediterranea sexual|type=transcript|length=3375bp
CGATCTCAGCAAGTGAAAATATTTGGCTTAAAATGCTTAGAAAATTTCAT
TTTATATAAATGGAATACTGCCGATAAAATTACAACTAGGGGATATCTAA
TCGAAATAATTAAAGAATAATTTTAACGTTGATAATGAATCTGAAAGAGT
AATAAGATGGATTATTGCCAAATCGGTTATGTATTTTATTCGCCATGAAT
GCCCACAAAACTGTGACAACATAATAATGGATTTAATTCACCTGAAAAAC
AATGGAATAATGACTCAGGCATTAGTGTTGTCAATTTTTTACTGTCTTTC
TGAATGTCTACCGATTGATTCTCAAATGCCGGATAAACGAAAAAAGGAAG
TCATTGGTTATCTAACGGAAAATTATGAAAATATCATTAAGTTTTCTCTA
GAAATTTTAAAAAGTTCCAATAACAACGAATGGTATTCATTAATTATTAA
GCTAGAATCTGTGAAGACAATACAAAGTTTTGCTGGTTGGATTAAATTTG
AGAGTCTATGCAAGCTGGCAGATGATATATTTTCCATTCTTATCCAATGC
TTGAATGTAAATAACTGTGATTATTATATCTTAGAAACTATCGAAACGAT
GCTAGAGCGAAAAACACGCGTCGAAGACAAATATTTGATGTTAAACATCC
TCATAAACAATGAATCAAATTGGTATAATCTACTTATCAACATCGAAACC
GGGCTTCAACTGGCTATCAATCCATATTCTGATGAGAAATTTAGGTATTT
GCAAAAAATAATGGACCTACTGTTGGTGATGGGAAATATTTTCATTAATT
GTTGGATGAAGTTTTCCCAACAATCAAGAAGTATTTGTTTTGATAAGTTT
ATCAACTCCATACAAATGGCAACGGCGTATCCTGTTAAGATTCTTGCTAT
TGAATTGTTATCTTTCTGGTATAATGGATTCAAAATCGACTGTGAGAACC
TTCGAACGACTTTGTCTTCCAGGGCGAATTTCTTACTGCCCTTATTGAAA
ATTTATTCAATGAAGCGAACCATTAGAGATCCAAGCAATGTAGACCACGA
ATATCTGTTGAATTTAATAGAACAGAAAGATGAAGAAAACTATGTAAATA
GAATACGTTATGAGGCATCCAGAGCTATTTCGTCTTTGACAGAACATTTT
ACCCAAGGGATTATAACACTGTGCTTAGATATGGTATATTCTGCAATTCT
TGATATTCAACAAAAAGGCGAATTATCGACTGATAGTAAAATGCAACTTG
AGGCTAGTAGATTTTTCTGTCGATGCGTTATGCACAACGTGTTACGTCCG
TACAGTAAAAACCTTCAAGACCAAGTGAAAGCGATCTTCACCAATTATCC
TACTGACATCGTCGTGAAAGGCAAAAATACTGTGACAACAATATTACGGT
TTGACAACTCGGATGCCGAAATTGTCATGATTTATACTGATTTGCTTTGT
TTGCTTATCCCTTTTGTTGCTGACCAGGAAGAAGTTGTCAAAGAATGTTT
GGAAAAGATCTTCATCTGGTTTCATATCCACGAATCAGTTGATCCGAAGC
ATCTGCATTATGGTTTGTGGCGCCAGGTTAACAAAAATTGTGGTGTATGC
ATTTTACGCATATTTCGAGATTATCACTTTCTACTCTCTAAATCTTTATT
TGAAACAATCCTTATCTATTATCAATCGAAATGTCAAAAGCTCTATGAAA
ATCCCATTATTGTCGAAGCAATGACGATTTATATACGTTCGAGCTCAAAT
TACACTGTGTCACAACAAGAAATTATTTTTGTTCGATTTTTTGACGATAT
AAAGTCTGTGCTTCTCAGTCAGTCATGTGCTTCAGTTTTTGAAAATGGGA
ATTCCGTTGTTAACTATTTACGACTGAACTACCCAGCACCAGTGAATGAA
CTTTCCCCTATTGCTGATCAAGATTTTAAACACAATGTTGTCCAAGCTAT
CTTTTGTCTATATGGAATATGTTGTAGAATCTCCTCTGAAACTGAAAATA
ATGTTGTTAACACGAAATCTCCGGAAACAATATCAATTATCTCATGTCCG
TTATATGAACACATCAGGGCCTTGCTACCGAGTCTTCTGAAAATCATACG
AGCGATCAATCAAGTTTGGAGTTCCAGTGTCATCCATGCTGAGTTTTCTA
GTTTAAAAGAAATATCTGATTATTATAAAGATACAATAATAAACAATAAA
CCTGCCGAGAAAATTCATCCTAACAATTCTCAATCTTTTGCTCAATTGTA
TGTAAATAGCTGTAGAAATTTTATTTCTCGTCTACACGAATCGACATGGT
TGATACTTGCTAAATGCTGCCTGAATTACAGTGGCCATCTGTATTATATA
AAGGAATGGCCACAGAGCGTTATTGAATATGTTTTCTCAGATCTCGATTC
TTTGCCAAATTTCAAATTAAACCCTTTGATAAAATCATTTGTCATTCCTT
TTGTTACTCACTGTCCTCTTGATCGGTTTGAAGAAGTTATGTCATTGACA
GTACTTCCTTTCATCAATTATACATTTCAGAGGTTGCATGAACAATGGTC
TACTATTGAAACTGATTCTGTAATGATGGAAGATGCTGATTTCGACGAAC
AGAACAATGATGGAAATAGCGAATTGTGTAATGAAATTATTGAAGAACAA
GTTCTTAGAATGCTTACGAAATCATTTTGCGAACTTATTAGATTGACATT
TACTATTGGATCGAATTTCGGAGATGATTCTGTGAAAGGCCTTAAATTCG
GAGTAATAGTCGACAGATTGTTCCAAACAAATCCAAATGAACAGTTGCCC
GTTATGTTAATGATCCTGAACAATGTTTGCCGATCTATTACCTGGAAAGA
TAGCTTTTGCTGTGCAAAACTGAGCCTCTTAATCCAGCCCATCGTGAATG
AAGTGAACTCTCGTGGTTTGTTGAACATTGACATCGTTATTTTCATATTT
CAACAACTGATTTGCGCATTGAATCTATTTTCGAGCGGTAATTTCATAGA
GATCAAGATCAGTTTACTCAACCTTGGTGTCAGTCTATATGATGATTTTA
TAGCGAAAGATTCTCAGTCTTCTAATAGATTTGTTTCGCTTTTAGATAAG
TCTTCTGAACAGTTAATAACGACATTCCAAAACAAAATGGCTGGTAAGTT
GAGCTTGAAAGTTAAAAGGGAAGTTCTTGAAAAACTCCTTCAGCCTTATA
TCCGTGTTTCTATAAATAAACTTTTTAGTCAAGAAGTATTTATCAAAGAT
TTGCCACCTCTCTTAAAACCTCATTGGAAGACTATTGGGAAAATGCCTTC
GACAAATCACGCTGAAGACTTGTTATGCCTGGAGGATTTGTTTAAACATT
AATAGTTGTACATAAAATAAATATT
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protein sequence of SMED30002210-orf-1

>SMED30002210-orf-1 ID=SMED30002210-orf-1|Name=SMED30002210-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1058bp
MYFIRHECPQNCDNIIMDLIHLKNNGIMTQALVLSIFYCLSECLPIDSQM
PDKRKKEVIGYLTENYENIIKFSLEILKSSNNNEWYSLIIKLESVKTIQS
FAGWIKFESLCKLADDIFSILIQCLNVNNCDYYILETIETMLERKTRVED
KYLMLNILINNESNWYNLLINIETGLQLAINPYSDEKFRYLQKIMDLLLV
MGNIFINCWMKFSQQSRSICFDKFINSIQMATAYPVKILAIELLSFWYNG
FKIDCENLRTTLSSRANFLLPLLKIYSMKRTIRDPSNVDHEYLLNLIEQK
DEENYVNRIRYEASRAISSLTEHFTQGIITLCLDMVYSAILDIQQKGELS
TDSKMQLEASRFFCRCVMHNVLRPYSKNLQDQVKAIFTNYPTDIVVKGKN
TVTTILRFDNSDAEIVMIYTDLLCLLIPFVADQEEVVKECLEKIFIWFHI
HESVDPKHLHYGLWRQVNKNCGVCILRIFRDYHFLLSKSLFETILIYYQS
KCQKLYENPIIVEAMTIYIRSSSNYTVSQQEIIFVRFFDDIKSVLLSQSC
ASVFENGNSVVNYLRLNYPAPVNELSPIADQDFKHNVVQAIFCLYGICCR
ISSETENNVVNTKSPETISIISCPLYEHIRALLPSLLKIIRAINQVWSSS
VIHAEFSSLKEISDYYKDTIINNKPAEKIHPNNSQSFAQLYVNSCRNFIS
RLHESTWLILAKCCLNYSGHLYYIKEWPQSVIEYVFSDLDSLPNFKLNPL
IKSFVIPFVTHCPLDRFEEVMSLTVLPFINYTFQRLHEQWSTIETDSVMM
EDADFDEQNNDGNSELCNEIIEEQVLRMLTKSFCELIRLTFTIGSNFGDD
SVKGLKFGVIVDRLFQTNPNEQLPVMLMILNNVCRSITWKDSFCCAKLSL
LIQPIVNEVNSRGLLNIDIVIFIFQQLICALNLFSSGNFIEIKISLLNLG
VSLYDDFIAKDSQSSNRFVSLLDKSSEQLITTFQNKMAGKLSLKVKREVL
EKLLQPYIRVSINKLFSQEVFIKDLPPLLKPHWKTIGKMPSTNHAEDLLC
LEDLFKH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005049nuclear export signal receptor activity
GO:1905172RISC complex binding
GO:0005488binding
GO:0090631pre-miRNA transporter activity
GO:0000049tRNA binding
GO:0003723RNA binding
GO:0003729mRNA binding
GO:0008536Ran GTPase binding
GO:0008565protein transporter activity
GO:0070883pre-miRNA binding
Vocabulary: cellular component
TermDefinition
GO:0016442RISC complex
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005737cytoplasm
GO:0005829cytosol
GO:0042565RNA nuclear export complex
Vocabulary: biological process
TermDefinition
GO:0051168nuclear export
GO:1900370positive regulation of RNA interference
GO:0006611protein export from nucleus
GO:0006810transport
GO:0006886intracellular protein transport
GO:0015031protein transport
GO:0031047gene silencing by RNA
GO:0035281pre-miRNA export from nucleus
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000140anterior region of the whole animal
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR011989ARM-like
IPR040018XPO5
IPR013598Exportin-1/Importin-b-like
IPR016024ARM-type_fold
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011989Armadillo-like helicalGENE3DG3DSA:1.25.10.10coord: 3..988
e-value: 1.1E-93
score: 316.5
IPR013598Exportin-1/Importin-beta-likePFAMPF08389Xpo1coord: 3..128
e-value: 3.4E-6
score: 27.2
NoneNo IPR availablePANTHERPTHR11223EXPORTIN 1/5coord: 4..1022
IPR040018Exportin-5PANTHERPTHR11223:SF3EXPORTIN-5coord: 4..1022