Transient receptor potential cation channel subfamily A member 1

Overview


Name	Transient receptor potential cation channel subfamily A member 1
Smed ID	SMED30002202
Length (bp)	529

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Transient receptor potential cation channel subfamily A member 1 (SMED30002202) t-SNE clustered cells

Violin plots show distribution of expression levels for Transient receptor potential cation channel subfamily A member 1 (SMED30002202) in cells (dots) of each of the 12 neoblast clusters.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30002202

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30002202	SMESG000078036.1	dd_Smed_v4_59687_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30002202	SMESG000078036.1	dd_Smed_v4_59687_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30002202	SMESG000078036.1	dd_Smed_v4_59687_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Human
Match: TRPA1 (transient receptor potential cation channel subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:497])

HSP 1 Score: 55.8398 bits (133), Expect = 6.265e-9
Identity = 30/96 (31.25%), Postives = 53/96 (55.21%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            DPF +  LS +++ +MM G+ +     +  +L  +  + V S   +  F I + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P
Sbjct:  896 DPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLP 991

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Human
Match: TRPA1 (transient receptor potential cation channel subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:497])

HSP 1 Score: 55.0694 bits (131), Expect = 9.847e-9
Identity = 30/96 (31.25%), Postives = 53/96 (55.21%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            DPF +  LS +++ +MM G+ +     +  +L  +  + V S   +  F I + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P
Sbjct:  748 DPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLP 843

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BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Celegans
Match: trpa-1 (Transient receptor potential cation channel subfamily A member 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q18297])

HSP 1 Score: 51.9878 bits (123), Expect = 4.564e-8
Identity = 31/104 (29.81%), Postives = 52/104 (50.00%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNY---------YVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQR 354
            F  I +S +K+  MM GEF+    F   +  +            +  +   F IIM+I L NL++GLAV DI  +  +A ++   ++V   L++E+ +   IQR
Sbjct: 1000 FSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLVGLAVDDIKGVQEKAELKRLAMQVDLVLQIEASLHFFIQR 1103

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Celegans
Match: trpa-1 (Transient receptor potential cation channel subfamily A member 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q18297])

HSP 1 Score: 51.9878 bits (123), Expect = 4.565e-8
Identity = 31/104 (29.81%), Postives = 52/104 (50.00%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNY---------YVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQR 354
            F  I +S +K+  MM GEF+    F   +  +            +  +   F IIM+I L NL++GLAV DI  +  +A ++   ++V   L++E+ +   IQR
Sbjct: 1001 FSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLVGLAVDDIKGVQEKAELKRLAMQVDLVLQIEASLHFFIQR 1104

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
Match: TrpA1 (gene:FBgn0035934 transcript:FBtr0331824)

HSP 1 Score: 69.3218 bits (168), Expect = 7.274e-14
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 1

Query:   40 YMLFFPF*DP------FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYY-------VTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKV-IQR 354
            Y+L     DP      F NI +S +++ +MM GE D V  ++     YY       +TS +++S+F+I+M I L NL+IGLAVGDI  +   A ++   ++V    E+E ++P V +QR
Sbjct:  983 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVN---TYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQR 1098

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
Match: TrpA1 (gene:FBgn0035934 transcript:FBtr0331827)

HSP 1 Score: 68.9366 bits (167), Expect = 7.982e-14
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 1

Query:   40 YMLFFPF*DP------FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYY-------VTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKV-IQR 354
            Y+L     DP      F NI +S +++ +MM GE D V  ++     YY       +TS +++S+F+I+M I L NL+IGLAVGDI  +   A ++   ++V    E+E ++P V +QR
Sbjct:  947 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVN---TYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQR 1062

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
Match: TrpA1 (gene:FBgn0035934 transcript:FBtr0331823)

HSP 1 Score: 68.9366 bits (167), Expect = 9.243e-14
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 1

Query:   40 YMLFFPF*DP------FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYY-------VTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKV-IQR 354
            Y+L     DP      F NI +S +++ +MM GE D V  ++     YY       +TS +++S+F+I+M I L NL+IGLAVGDI  +   A ++   ++V    E+E ++P V +QR
Sbjct:  984 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVN---TYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQR 1099

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
Match: TrpA1 (gene:FBgn0035934 transcript:FBtr0331826)

HSP 1 Score: 68.9366 bits (167), Expect = 9.576e-14
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 1

Query:   40 YMLFFPF*DP------FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYY-------VTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKV-IQR 354
            Y+L     DP      F NI +S +++ +MM GE D V  ++     YY       +TS +++S+F+I+M I L NL+IGLAVGDI  +   A ++   ++V    E+E ++P V +QR
Sbjct:  948 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVN---TYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQR 1063

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
Match: TrpA1 (gene:FBgn0035934 transcript:FBtr0331825)

HSP 1 Score: 68.5514 bits (166), Expect = 1.252e-13
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 1

Query:   40 YMLFFPF*DP------FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYY-------VTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKV-IQR 354
            Y+L     DP      F NI +S +++ +MM GE D V  ++     YY       +TS +++S+F+I+M I L NL+IGLAVGDI  +   A ++   ++V    E+E ++P V +QR
Sbjct:  949 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVN---TYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQR 1064

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Zebrafish
Match: trpa1b (transient receptor potential cation channel, subfamily A, member 1b [Source:ZFIN;Acc:ZDB-GENE-050106-1])

HSP 1 Score: 55.0694 bits (131), Expect = 6.535e-9
Identity = 32/107 (29.91%), Postives = 55/107 (51.40%), Query Frame = 1

Query:   31 FSKYMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F   ML  P    F +I+L+  ++  M  GE +  + FL     G   +   + ++   FV++M I L NL+IGLAVGDI E+   A ++   +++     +E ++P
Sbjct:  893 FYALMLHRP---EFSSISLALAQTFVMTVGELNYQSTFLNSYEEGHMAFPAITYLVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAELKRIAMQIDLHTALEEKLP 996

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Zebrafish
Match: trpa1b (transient receptor potential cation channel, subfamily A, member 1b [Source:ZFIN;Acc:ZDB-GENE-050106-1])

HSP 1 Score: 55.0694 bits (131), Expect = 6.715e-9
Identity = 32/107 (29.91%), Postives = 55/107 (51.40%), Query Frame = 1

Query:   31 FSKYMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F   ML  P    F +I+L+  ++  M  GE +  + FL     G   +   + ++   FV++M I L NL+IGLAVGDI E+   A ++   +++     +E ++P
Sbjct:  880 FYALMLHRP---EFSSISLALAQTFVMTVGELNYQSTFLNSYEEGHMAFPAITYLVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAELKRIAMQIDLHTALEEKLP 983

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Zebrafish
Match: trpa1b (transient receptor potential cation channel, subfamily A, member 1b [Source:ZFIN;Acc:ZDB-GENE-050106-1])

HSP 1 Score: 55.0694 bits (131), Expect = 6.715e-9
Identity = 32/107 (29.91%), Postives = 55/107 (51.40%), Query Frame = 1

Query:   31 FSKYMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F   ML  P    F +I+L+  ++  M  GE +  + FL     G   +   + ++   FV++M I L NL+IGLAVGDI E+   A ++   +++     +E ++P
Sbjct:  880 FYALMLHRP---EFSSISLALAQTFVMTVGELNYQSTFLNSYEEGHMAFPAITYLVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAELKRIAMQIDLHTALEEKLP 983

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Zebrafish
Match: trpa1a (transient receptor potential cation channel, subfamily A, member 1a [Source:ZFIN;Acc:ZDB-GENE-050105-6])

HSP 1 Score: 53.5286 bits (127), Expect = 2.290e-8
Identity = 28/94 (29.79%), Postives = 52/94 (55.32%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F  + LS +++  MM GE +     +  +L G   +   ++ +   FV+++ I L NL+IGLAVGDI E+ + A ++   +++     +E R+P
Sbjct:  904 FGRMFLSLLQTFVMMVGEMNYQDNFMKPYLQGDLPFPDLTLAIFVWFVLLVPILLMNLLIGLAVGDIAEVQTNACLKRIAMQIELHTNLEERLP 997

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
Match: trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:NCBI gene;Acc:100158526])

HSP 1 Score: 50.447 bits (119), Expect = 3.886e-7
Identity = 31/109 (28.44%), Postives = 55/109 (50.46%), Query Frame = 1

Query:   34 SKYMLFFP---F*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            S Y+  +P   F  P+     + M+S  MM G+ +    FL      +  Y   + + + +F +++ I L NL+IGLAVGDI E+   A ++   ++V     +E ++P
Sbjct:  837 SFYVFLYPQVTFSRPY----FALMQSFTMMLGDINYEEGFLKPLLDDQIEYPFFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSLHTSLEKKLP 941

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
Match: trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:NCBI gene;Acc:100158526])

HSP 1 Score: 50.447 bits (119), Expect = 4.392e-7
Identity = 31/109 (28.44%), Postives = 55/109 (50.46%), Query Frame = 1

Query:   34 SKYMLFFP---F*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            S Y+  +P   F  P+     + M+S  MM G+ +    FL      +  Y   + + + +F +++ I L NL+IGLAVGDI E+   A ++   ++V     +E ++P
Sbjct:  831 SFYVFLYPQVTFSRPY----FALMQSFTMMLGDINYEEGFLKPLLDDQIEYPFFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSLHTSLEKKLP 935

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
Match: trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:NCBI gene;Acc:100158526])

HSP 1 Score: 50.447 bits (119), Expect = 4.505e-7
Identity = 31/109 (28.44%), Postives = 55/109 (50.46%), Query Frame = 1

Query:   34 SKYMLFFP---F*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            S Y+  +P   F  P+     + M+S  MM G+ +    FL      +  Y   + + + +F +++ I L NL+IGLAVGDI E+   A ++   ++V     +E ++P
Sbjct:  801 SFYVFLYPQVTFSRPY----FALMQSFTMMLGDINYEEGFLKPLLDDQIEYPFFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSLHTSLEKKLP 905

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
Match: trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:NCBI gene;Acc:100158526])

HSP 1 Score: 50.447 bits (119), Expect = 4.531e-7
Identity = 31/109 (28.44%), Postives = 55/109 (50.46%), Query Frame = 1

Query:   34 SKYMLFFP---F*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            S Y+  +P   F  P+     + M+S  MM G+ +    FL      +  Y   + + + +F +++ I L NL+IGLAVGDI E+   A ++   ++V     +E ++P
Sbjct:  859 SFYVFLYPQVTFSRPY----FALMQSFTMMLGDINYEEGFLKPLLDDQIEYPFFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSLHTSLEKKLP 963

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
Match: trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:NCBI gene;Acc:100158526])

HSP 1 Score: 50.447 bits (119), Expect = 4.553e-7
Identity = 31/109 (28.44%), Postives = 55/109 (50.46%), Query Frame = 1

Query:   34 SKYMLFFP---F*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            S Y+  +P   F  P+     + M+S  MM G+ +    FL      +  Y   + + + +F +++ I L NL+IGLAVGDI E+   A ++   ++V     +E ++P
Sbjct:  912 SFYVFLYPQVTFSRPY----FALMQSFTMMLGDINYEEGFLKPLLDDQIEYPFFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSLHTSLEKKLP 1016

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Mouse
Match: Trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:MGI Symbol;Acc:MGI:3522699])

HSP 1 Score: 52.7582 bits (125), Expect = 4.788e-8
Identity = 34/114 (29.82%), Postives = 57/114 (50.00%), Query Frame = 1

Query:   40 YMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP-----KVIQR 354
            + +   F D F    LS +++ +MM G+ +    FL      +  Y V +   +  F + + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P     KV QR
Sbjct:  861 FYVLLNFQDAFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWYLRKVDQR 974

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Mouse
Match: Trpa1 (transient receptor potential cation channel, subfamily A, member 1 [Source:MGI Symbol;Acc:MGI:3522699])

HSP 1 Score: 52.373 bits (124), Expect = 6.565e-8
Identity = 34/114 (29.82%), Postives = 57/114 (50.00%), Query Frame = 1

Query:   40 YMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP-----KVIQR 354
            + +   F D F    LS +++ +MM G+ +    FL      +  Y V +   +  F + + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P     KV QR
Sbjct:  891 FYVLLNFQDAFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWYLRKVDQR 1004

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
Match: sp|Q7Z020|TRPA1_DROME (Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster OX=7227 GN=TrpA1 PE=2 SV=4)

HSP 1 Score: 68.5514 bits (166), Expect = 1.255e-12
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 1

Query:   40 YMLFFPF*DP------FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYY-------VTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKV-IQR 354
            Y+L     DP      F NI +S +++ +MM GE D V  ++     YY       +TS +++S+F+I+M I L NL+IGLAVGDI  +   A ++   ++V    E+E ++P V +QR
Sbjct:  949 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVN---TYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQR 1064

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
Match: sp|O75762|TRPA1_HUMAN (Transient receptor potential cation channel subfamily A member 1 OS=Homo sapiens OX=9606 GN=TRPA1 PE=1 SV=3)

HSP 1 Score: 55.8398 bits (133), Expect = 3.009e-8
Identity = 30/96 (31.25%), Postives = 53/96 (55.21%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            DPF +  LS +++ +MM G+ +     +  +L  +  + V S   +  F I + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P
Sbjct:  896 DPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLP 991

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
Match: sp|Q8BLA8|TRPA1_MOUSE (Transient receptor potential cation channel subfamily A member 1 OS=Mus musculus OX=10090 GN=Trpa1 PE=1 SV=1)

HSP 1 Score: 52.373 bits (124), Expect = 4.592e-7
Identity = 34/114 (29.82%), Postives = 57/114 (50.00%), Query Frame = 1

Query:   40 YMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP-----KVIQR 354
            + +   F D F    LS +++ +MM G+ +    FL      +  Y V +   +  F + + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P     KV QR
Sbjct:  891 FYVLLNFQDAFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWYLRKVDQR 1004

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
Match: sp|Q6RI86|TRPA1_RAT (Transient receptor potential cation channel subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Trpa1 PE=2 SV=1)

HSP 1 Score: 52.373 bits (124), Expect = 4.861e-7
Identity = 34/114 (29.82%), Postives = 57/114 (50.00%), Query Frame = 1

Query:   40 YMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT----GKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP-----KVIQR 354
            + +   F D F    LS +++ +MM G+ +    FL      +  Y V +   +  F + + I L NL+IGLAVGDI E+   A+++   ++V     +E ++P     KV QR
Sbjct:  891 FYVLLNFQDAFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQR 1004

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
Match: sp|Q18297|TRPA1_CAEEL (Transient receptor potential cation channel subfamily A member 1 homolog OS=Caenorhabditis elegans OX=6239 GN=trpa-1 PE=2 SV=5)

HSP 1 Score: 51.9878 bits (123), Expect = 5.806e-7
Identity = 31/104 (29.81%), Postives = 52/104 (50.00%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFDLVTYFLTGKKNY---------YVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQR 354
            F  I +S +K+  MM GEF+    F   +  +            +  +   F IIM+I L NL++GLAV DI  +  +A ++   ++V   L++E+ +   IQR
Sbjct: 1001 FSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLVGLAVDDIKGVQEKAELKRLAMQVDLVLQIEASLHFFIQR 1104

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
Match: A0A267H4H8 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010017g1 PE=3 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 3.082e-16
Identity = 47/117 (40.17%), Postives = 74/117 (63.25%), Query Frame = 1

Query:   31 FSKYMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLTG-------KKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFL 360
            +SK +   P  D + +  L+ +K+L MM GEFD V  F +          ++YVT+ V++ LF+I+M I L NL+IGLAVGDI  + ++AT++  +L+V +F E+ES+ P+   RFL
Sbjct: 1026 YSKSLDADPNLDAWNHPVLAILKTLMMMLGEFDYVATFTSKLLDGDPRTNHFYVTNFVLLVLFIILMPILLMNLLIGLAVGDIETVQNDATLQRIRLQVEWFAELESKFPR---RFL 1139

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
Match: A0A1I8I8B2 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 3.164e-16
Identity = 47/117 (40.17%), Postives = 74/117 (63.25%), Query Frame = 1

Query:   31 FSKYMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLTG-------KKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFL 360
            +SK +   P  D + +  L+ +K+L MM GEFD V  F +          ++YVT+ V++ LF+I+M I L NL+IGLAVGDI  + ++AT++  +L+V +F E+ES+ P+   RFL
Sbjct: 1662 YSKSLDADPNLDAWNHPVLAILKTLMMMLGEFDYVATFTSKLLDGDPRTNHFYVTNFVLLVLFIILMPILLMNLLIGLAVGDIETVQNDATLQRIRLQVEWFAELESKFPR---RFL 1775

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
Match: A0A267E899 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025935g1 PE=3 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 4.128e-15
Identity = 40/100 (40.00%), Postives = 63/100 (63.00%), Query Frame = 1

Query:   67 PFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSI-VMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLY 363
            PFK I  S +K+  M  GE D VTYF++       T + V+  +FVIIM I L NL++G+AVGDI  ++ EA+++   +++  F E+E+ +P+  QR L+
Sbjct: 1004 PFKYITYSILKTFDMTVGELDFVTYFISNSYGGMQTGLLVVFVIFVIIMPIGLMNLLVGIAVGDIDGISKEASLKLIDIRITLFYELETNLPRYFQRRLH 1103

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
Match: A0A267FPG6 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025935g2 PE=3 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 4.128e-15
Identity = 40/100 (40.00%), Postives = 63/100 (63.00%), Query Frame = 1

Query:   67 PFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSI-VMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLY 363
            PFK I  S +K+  M  GE D VTYF++       T + V+  +FVIIM I L NL++G+AVGDI  ++ EA+++   +++  F E+E+ +P+  QR L+
Sbjct: 1004 PFKYITYSILKTFDMTVGELDFVTYFISNSYGGMQTGLLVVFVIFVIIMPIGLMNLLVGIAVGDIDGISKEASLKLIDIRITLFYELETNLPRYFQRRLH 1103

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
Match: A0A2B4SJT6 (Transient receptor potential cation channel subfamily A member 1 OS=Stylophora pistillata OX=50429 GN=TRPA1 PE=3 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 6.917e-13
Identity = 42/119 (35.29%), Postives = 69/119 (57.98%), Query Frame = 1

Query:   40 YMLFFPF*DPFKNIALSYMKSLAMMTGEFDLVTYFLT---------GKKNYYV-TSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYH 366
            Y+LF    D F+  ++++MK++ MM GE +    F+           +KN +  TS V +SLF+I++ I L NL++GLAVGDI  +   AT++   ++V +  E+E   P+ + R LYH
Sbjct:  897 YILFKEL-DSFQKPSIAFMKTIVMMIGELEFDDTFVETIGKNTTSGARKNPFPETSFVFLSLFLILVGIVLMNLLVGLAVGDIDTIQQSATLKRLAMQVEFVAEIEQSYPRFVTRRLYH 1014

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Cavefish
Match: trpa1b (transient receptor potential cation channel subfamily A member 1 [Source:NCBI gene;Acc:103042231])

HSP 1 Score: 57.7658 bits (138), Expect = 8.252e-10
Identity = 31/94 (32.98%), Postives = 53/94 (56.38%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F +I+LS  ++  M  GE +    L+  +  G+  +   S  +  LFV++M I L NL+IGLAVGDI E+   AT++   +++     +E ++P
Sbjct:  885 FNSISLSLAQTFVMTVGELNYQNTLLEAYEQGQLAFPEISYFIFVLFVLLMPILLMNLMIGLAVGDIAEVQRNATLKRIAMQINLHTNLEEKLP 978

[Close]

Query:   70 FKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F +I+LS  ++  M  GE +    L+  +  G+  +   S  +  LFV++M I L NL+IGLAVGDI E+   AT++   +++     +E ++P
Sbjct:  885 FNSISLSLAQTFVMTVGELNYQNTLLEAYEQGQLAFPEISYFIFVLFVLLMPILLMNLMIGLAVGDIAEVQRNATLKRIAMQINLHTNLEEKLP 978

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Cavefish
Match: trpa1b (transient receptor potential cation channel subfamily A member 1 [Source:NCBI gene;Acc:103042231])

HSP 1 Score: 57.3806 bits (137), Expect = 8.762e-10
Identity = 31/94 (32.98%), Postives = 53/94 (56.38%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F +I+LS  ++  M  GE +    L+  +  G+  +   S  +  LFV++M I L NL+IGLAVGDI E+   AT++   +++     +E ++P
Sbjct:  885 FNSISLSLAQTFVMTVGELNYQNTLLEAYEQGQLAFPEISYFIFVLFVLLMPILLMNLMIGLAVGDIAEVQRNATLKRIAMQINLHTNLEEKLP 978

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Cavefish
Match: trpa1a (transient receptor potential cation channel subfamily A member 1-like [Source:NCBI gene;Acc:103022174])

HSP 1 Score: 52.7582 bits (125), Expect = 3.644e-8
Identity = 27/94 (28.72%), Postives = 53/94 (56.38%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEF----DLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F  + LS M++  MM GE     + +  +++ +  + + +  +   FV+++ I L NL+IGLAVGDI E+ + A ++   +++     +E R+P
Sbjct:  848 FGRMFLSLMQTFVMMVGEISYQDNFLKPYMSSQLPFPLMTYGIFVWFVLLVPILLMNLLIGLAVGDIAEVQTNACLKQIGMQIELHSNLEERLP 941

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Cavefish
Match: trpa1a (transient receptor potential cation channel subfamily A member 1-like [Source:NCBI gene;Acc:103022174])

HSP 1 Score: 52.7582 bits (125), Expect = 3.655e-8
Identity = 27/94 (28.72%), Postives = 53/94 (56.38%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEF----DLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F  + LS M++  MM GE     + +  +++ +  + + +  +   FV+++ I L NL+IGLAVGDI E+ + A ++   +++     +E R+P
Sbjct:  878 FGRMFLSLMQTFVMMVGEISYQDNFLKPYMSSQLPFPLMTYGIFVWFVLLVPILLMNLLIGLAVGDIAEVQTNACLKQIGMQIELHSNLEERLP 971

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Nematostella
Match: EDO33180 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST04])

HSP 1 Score: 51.2174 bits (121), Expect = 4.737e-8
Identity = 30/112 (26.79%), Postives = 57/112 (50.89%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGE--FDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNK 399
            F  +  S   +  ++ GE  +    Y      N +++ I+ I +F + M I + NL+IGL+VGD+  +   A ME + ++V   LE+E   P+ + R ++ +   +   +NK
Sbjct:  419 FDELPYSLFTTFMLILGEMKYPHTVYKYQPIPNPWISYIIYI-IFCVCMPIIIKNLLIGLSVGDVNRILQTAKMEQHAMQVELLLELERATPRRVLRKIWVAYFVDFPNRNK 529

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Nematostella
Match: EDO38701 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC56])

HSP 1 Score: 46.595 bits (109), Expect = 9.897e-7
Identity = 28/96 (29.17%), Postives = 49/96 (51.04%), Query Frame = 1

Query:   67 PFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQR 354
            PF     S +K+   M GEF+  T +          +  +   F++I  I L NL++GLAV DI  +  +A ++   ++V   L+VE  +P +++R
Sbjct:   48 PFATPGRSMLKTTMGMLGEFEYDTVY--NDNEVPPIAWALYVCFLVINCIILMNLLVGLAVDDIKGVQEKAVLKRLAMQVDLVLDVEKALPAMLRR 141

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Medaka
Match: trpa1b (transient receptor potential cation channel subfamily A member 1 [Source:NCBI gene;Acc:101174541])

HSP 1 Score: 57.3806 bits (137), Expect = 1.072e-9
Identity = 28/94 (29.79%), Postives = 54/94 (57.45%), Query Frame = 1

Query:   70 FKNIALSYMKSLAMMTGEFD----LVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVP 339
            F+ + LS +++  MM GE +    ++  FL  +  + + +  +   FV++M I L NL+IGLAVGDI E+   A+++   +++     +E ++P
Sbjct:  893 FETVPLSVIQTFVMMVGELNYQNNILDAFLKNELPFGILTYFIFVQFVMLMPILLVNLMIGLAVGDIAEVQRNASLKRIAMQIDLHTSLEDKLP 986

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST
Match: SMESG000078036.1 (SMESG000078036.1)

HSP 1 Score: 244.973 bits (624), Expect = 8.599e-84
Identity = 120/120 (100.00%), Postives = 120/120 (100.00%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNKKRFSLFHL 423
            DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNKKRFSLFHL
Sbjct:   59 DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNKKRFSLFHL 178

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST
Match: SMESG000078034.1 (SMESG000078034.1)

HSP 1 Score: 202.216 bits (513), Expect = 2.250e-67
Identity = 93/115 (80.87%), Postives = 109/115 (94.78%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNKKRF 408
            DPFKN+ L+YMKSLAMMTGEFDLVTYF++GKKNYYVTS++MISLFV+IMSI+LFNLIIGLAVGDIG++ASEATM+AYKLKVGY +EVE+ VP VIQR+LYHSEIC+  KQ+KKRF
Sbjct:    2 DPFKNLGLAYMKSLAMMTGEFDLVTYFVSGKKNYYVTSLIMISLFVVIMSISLFNLIIGLAVGDIGDIASEATMQAYKLKVGYIMEVETNVPTVIQRYLYHSEICDRPKQHKKRF 116

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST
Match: SMESG000078034.1 (SMESG000078034.1)

HSP 1 Score: 202.601 bits (514), Expect = 4.466e-65
Identity = 93/115 (80.87%), Postives = 109/115 (94.78%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNKKRF 408
            DPFKN+ L+YMKSLAMMTGEFDLVTYF++GKKNYYVTS++MISLFV+IMSI+LFNLIIGLAVGDIG++ASEATM+AYKLKVGY +EVE+ VP VIQR+LYHSEIC+  KQ+KKRF
Sbjct:  184 DPFKNLGLAYMKSLAMMTGEFDLVTYFVSGKKNYYVTSLIMISLFVVIMSISLFNLIIGLAVGDIGDIASEATMQAYKLKVGYIMEVETNVPTVIQRYLYHSEICDRPKQHKKRF 298

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST
Match: SMESG000078034.1 (SMESG000078034.1)

HSP 1 Score: 184.882 bits (468), Expect = 8.779e-61
Identity = 86/105 (81.90%), Postives = 100/105 (95.24%), Query Frame = 1

Query:   94 MKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQNKKRF 408
            MKSLAMMTGEFDLVTYF++GKKNYYVTS++MISLFV+IMSI+LFNLIIGLAVGDIG++ASEATM+AYKLKVGY +EVE+ VP VIQR+LYHSEIC+  KQ+KKRF
Sbjct:    1 MKSLAMMTGEFDLVTYFVSGKKNYYVTSLIMISLFVVIMSISLFNLIIGLAVGDIGDIASEATMQAYKLKVGYIMEVETNVPTVIQRYLYHSEICDRPKQHKKRF 105

[Close]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST
Match: SMESG000078036.1 (SMESG000078036.1)

HSP 1 Score: 191.045 bits (484), Expect = 4.977e-57
Identity = 93/97 (95.88%), Postives = 96/97 (98.97%), Query Frame = 1

Query:   64 DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQR 354
            DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPK +++
Sbjct:   59 DPFKNIALSYMKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGLAVGDIGEMASEATMEAYKLKVGYFLEVESRVPKALKK 155

The following BLAST results are available for this feature:

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Human
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Celegans
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Zebrafish
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Mouse
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Cavefish
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Sea Lamprey
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Yeast
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Nematostella
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Medaka
BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
TRPA1	6.265e-9	31.25	transient receptor potential cation channel subfam...	[more]
TRPA1	9.847e-9	31.25	transient receptor potential cation channel subfam...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
trpa-1	4.564e-8	29.81	Transient receptor potential cation channel subfam...	[more]
trpa-1	4.565e-8	29.81	Transient receptor potential cation channel subfam...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TrpA1	7.274e-14	35.29	gene:FBgn0035934 transcript:FBtr0331824	[more]
TrpA1	7.982e-14	35.29	gene:FBgn0035934 transcript:FBtr0331827	[more]
TrpA1	9.243e-14	35.29	gene:FBgn0035934 transcript:FBtr0331823	[more]
TrpA1	9.576e-14	35.29	gene:FBgn0035934 transcript:FBtr0331826	[more]
TrpA1	1.252e-13	35.29	gene:FBgn0035934 transcript:FBtr0331825	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
trpa1b	6.535e-9	29.91	transient receptor potential cation channel, subfa...	[more]
trpa1b	6.715e-9	29.91	transient receptor potential cation channel, subfa...	[more]
trpa1b	6.715e-9	29.91	transient receptor potential cation channel, subfa...	[more]
trpa1a	2.290e-8	29.79	transient receptor potential cation channel, subfa...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trpa1	3.886e-7	28.44	transient receptor potential cation channel, subfa...	[more]
trpa1	4.392e-7	28.44	transient receptor potential cation channel, subfa...	[more]
trpa1	4.505e-7	28.44	transient receptor potential cation channel, subfa...	[more]
trpa1	4.531e-7	28.44	transient receptor potential cation channel, subfa...	[more]
trpa1	4.553e-7	28.44	transient receptor potential cation channel, subfa...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Trpa1	4.788e-8	29.82	transient receptor potential cation channel, subfa...	[more]
Trpa1	6.565e-8	29.82	transient receptor potential cation channel, subfa...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q7Z020\|TRPA1_DROME	1.255e-12	35.29	Transient receptor potential cation channel subfam...	[more]
sp\|O75762\|TRPA1_HUMAN	3.009e-8	31.25	Transient receptor potential cation channel subfam...	[more]
sp\|Q8BLA8\|TRPA1_MOUSE	4.592e-7	29.82	Transient receptor potential cation channel subfam...	[more]
sp\|Q6RI86\|TRPA1_RAT	4.861e-7	29.82	Transient receptor potential cation channel subfam...	[more]
sp\|Q18297\|TRPA1_CAEEL	5.806e-7	29.81	Transient receptor potential cation channel subfam...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267H4H8	3.082e-16	40.17	ANK_REP_REGION domain-containing protein OS=Macros...	[more]
A0A1I8I8B2	3.164e-16	40.17	ANK_REP_REGION domain-containing protein OS=Macros...	[more]
A0A267E899	4.128e-15	40.00	ANK_REP_REGION domain-containing protein OS=Macros...	[more]
A0A267FPG6	4.128e-15	40.00	ANK_REP_REGION domain-containing protein OS=Macros...	[more]
A0A2B4SJT6	6.917e-13	35.29	Transient receptor potential cation channel subfam...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trpa1b	8.252e-10	32.98	transient receptor potential cation channel subfam...	[more]
trpa1b	8.252e-10	32.98	transient receptor potential cation channel subfam...	[more]
trpa1b	8.762e-10	32.98	transient receptor potential cation channel subfam...	[more]
trpa1a	3.644e-8	28.72	transient receptor potential cation channel subfam...	[more]
trpa1a	3.655e-8	28.72	transient receptor potential cation channel subfam...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO33180	4.737e-8	26.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38701	9.897e-7	29.17	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
trpa1b	1.072e-9	29.79	transient receptor potential cation channel subfam...	[more]

BLAST of Transient receptor potential cation channel subfamily A member 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000078036.1	8.599e-84	100.00	SMESG000078036.1	[more]
SMESG000078034.1	2.250e-67	80.87	SMESG000078034.1	[more]
SMESG000078034.1	4.466e-65	80.87	SMESG000078034.1	[more]
SMESG000078034.1	8.779e-61	81.90	SMESG000078034.1	[more]
SMESG000078036.1	4.977e-57	95.88	SMESG000078036.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30002202 ID=SMED30002202|Name=Transient receptor potential cation channel subfamily A member 1|organism=Schmidtea mediterranea sexual|type=transcript|length=529bp
GTAGATTTTATTCCAAAATTATTTTGTTAATTTTCTAAATATATGCTATT
TTTTCCTTTTTAGGATCCATTTAAGAATATTGCTTTATCCTATATGAAAA
GCCTCGCTATGATGACCGGAGAATTTGATCTGGTTACGTATTTCCTGACT
GGAAAGAAAAATTACTACGTTACATCAATTGTTATGATTTCCCTTTTTGT
AATAATTATGTCAATCACTCTGTTCAATTTAATCATTGGGCTTGCTGTTG
GTGACATTGGTGAAATGGCATCGGAAGCAACAATGGAGGCATACAAGCTA
AAGGTCGGCTACTTTTTAGAAGTAGAGTCCAGAGTACCGAAAGTAATTCA
GCGATTTTTGTATCATTCGGAAATTTGTGAAGGTACGAAACAAAATAAAA
AACGTTTTTCTCTTTTTCACTTGTAATATATTCCAACCAGATACAATGTG
AAAAACTATCAACATTTATATATTTATCGAACATTTAATATATTTGTCCT
GTGTAATATCAATGAATTTTAGTTGTGGG

protein sequence of SMED30002202-orf-1

>SMED30002202-orf-1 ID=SMED30002202-orf-1|Name=SMED30002202-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=111bp
MKSLAMMTGEFDLVTYFLTGKKNYYVTSIVMISLFVIIMSITLFNLIIGL
AVGDIGEMASEATMEAYKLKVGYFLEVESRVPKVIQRFLYHSEICEGTKQ
NKKRFSLFHL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR005821	Ion_trans_dom

Vocabulary: **biological process**
Term	Definition
GO:0006811	ion transport
GO:0055085	transmembrane transport
GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007602	phototransduction
GO:0007638	mechanosensory behavior
GO:0009408	response to heat
GO:0009416	response to light stimulus
GO:0010378	temperature compensation of the circadian clock
GO:0019233	sensory perception of pain
GO:0023041	neuronal signal transduction
GO:0034220	ion transmembrane transport
GO:0034605	cellular response to heat
GO:0040040	thermosensory behavior
GO:0043052	thermotaxis
GO:0046957	negative phototaxis
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050896	response to stimulus
GO:0050960	detection of temperature stimulus involved in thermoception
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0070588	calcium ion transmembrane transport
GO:0098655	cation transmembrane transport

Vocabulary: **molecular function**
Term	Definition
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0015276	ligand-gated ion channel activity
GO:0097604	temperature-gated cation channel activity

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0034703	cation channel complex

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PANTHER	PTHR47143	FAMILY NOT NAMED	coord: 1..92
None	No IPR available	TMHMM	TMhelix		coord: 26..48

Main menu

Transient receptor potential cation channel subfamily A member 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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