HEAT repeat-containing protein 4

Overview
NameHEAT repeat-containing protein 4
Smed IDSMED30002145
Length (bp)3897
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of HEAT repeat-containing protein 4 (SMED30002145) t-SNE clustered cells

Violin plots show distribution of expression levels for HEAT repeat-containing protein 4 (SMED30002145) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HEAT repeat-containing protein 4 (SMED30002145) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HEAT repeat-containing protein 4 (SMED30002145) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30002145

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30002145SMESG000024853.1 SMESG000024852.1 SmedASXL_017533SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v4_16127_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v4_16127_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v4_16127_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v4_16127_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v4_16127_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v6_16127_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30002145SMESG000024853.1 SMESG000024852.1 dd_Smed_v4_16127_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Human
Match: HEATR4 (HEAT repeat containing 4 [Source:HGNC Symbol;Acc:HGNC:16761])

HSP 1 Score: 264.618 bits (675), Expect = 2.023e-72
Identity = 184/622 (29.58%), Postives = 327/622 (52.57%), Query Frame = 2 
Query: 1001 FYRLPVLVRKTKKTNKEVNIESVNPTTRSLKE---FQLPKTPP--KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKA---DNALELENLERQNSRKRARDHSSLNLLV-----DQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTN---TVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAI 2818
            +YRLP   ++ +     V I   N +T  + E      P+T    + V  + G     TDN +++++YF+E +   ++  K D I+  +   Y K L  ++P   T  ++S + + ++        +G  RWT LP   ++ L++    D  ++   L++Q   K  ++  +  L+V      +W+  W L  ++   TV+ LL+ + D+H  +R++AI T A AA         Q +   T+Q+      LP +L+ A+E  L D +  VR AAAI  ++++     + NI++  L+  +++D WAA QCLA+  +A   VI  ++ QL   ++    E++  LL+ +S  + L+H ML  +LN+  W+ R++ C+  S + G +  D+  K+I LMW+D +K+V+ AA+Q LG+   GK VH+ +  KL   +   R +AL  IG LK+MT +++P+FL CF D+F  VR+  C A   L+I+D + +E LL L + DP WK+K +AI+AL +      E+   +LWA+ +E    +RL A + I  +      + D      L+E+  ++L+ +++ +  +N+    +   + EIK  + K  S KD + + IL  E +
Sbjct:  292 YYRLPSYFQQAET----VEIMPGNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQIIHQIGAKRDQIVLENLNRYNKQLSKVFP--ETPEKWSAQAIPEASYRPV---QGALRWTALPTPAKDMLLQVGEKDVPIKTRRLKKQA--KSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETVENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDSDKTIQD------LPEVLLPALEAALCDKNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNSVDSWAAAQCLALEGTATYPVIKRILHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNVCLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLIGELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIKAFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLLLENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRI-KTLSQKDLLTHKILKLEMV 895
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Human
Match: HEATR4 (HEAT repeat containing 4 [Source:HGNC Symbol;Acc:HGNC:16761])

HSP 1 Score: 264.618 bits (675), Expect = 2.023e-72
Identity = 184/622 (29.58%), Postives = 327/622 (52.57%), Query Frame = 2 
Query: 1001 FYRLPVLVRKTKKTNKEVNIESVNPTTRSLKE---FQLPKTPP--KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKA---DNALELENLERQNSRKRARDHSSLNLLV-----DQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTN---TVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAI 2818
            +YRLP   ++ +     V I   N +T  + E      P+T    + V  + G     TDN +++++YF+E +   ++  K D I+  +   Y K L  ++P   T  ++S + + ++        +G  RWT LP   ++ L++    D  ++   L++Q   K  ++  +  L+V      +W+  W L  ++   TV+ LL+ + D+H  +R++AI T A AA         Q +   T+Q+      LP +L+ A+E  L D +  VR AAAI  ++++     + NI++  L+  +++D WAA QCLA+  +A   VI  ++ QL   ++    E++  LL+ +S  + L+H ML  +LN+  W+ R++ C+  S + G +  D+  K+I LMW+D +K+V+ AA+Q LG+   GK VH+ +  KL   +   R +AL  IG LK+MT +++P+FL CF D+F  VR+  C A   L+I+D + +E LL L + DP WK+K +AI+AL +      E+   +LWA+ +E    +RL A + I  +      + D      L+E+  ++L+ +++ +  +N+    +   + EIK  + K  S KD + + IL  E +
Sbjct:  292 YYRLPSYFQQAET----VEIMPGNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQIIHQIGAKRDQIVLENLNRYNKQLSKVFP--ETPEKWSAQAIPEASYRPV---QGALRWTALPTPAKDMLLQVGEKDVPIKTRRLKKQA--KSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETVENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDSDKTIQD------LPEVLLPALEAALCDKNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNSVDSWAAAQCLALEGTATYPVIKRILHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNVCLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLIGELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIKAFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLLLENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRI-KTLSQKDLLTHKILKLEMV 895
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Zebrafish
Match: si:dkey-13p1.3 (si:dkey-13p1.3 [Source:ZFIN;Acc:ZDB-GENE-131121-470])

HSP 1 Score: 191.045 bits (484), Expect = 3.287e-50
Identity = 134/448 (29.91%), Postives = 228/448 (50.89%), Query Frame = 2 
Query: 1487 SSLNLLVDQWR--------KKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQK--YGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELL---ISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHII 2791
            S+L   VD+WR        +  Q    +   T+  L RD+ D +  +RL+AIVT A  A     Q+  +G+       +    +   L+  I   L+DP  +VR AAA+  +++      + +IL  ++   +S +  D W A QCLA+  +A   VI  L+ Q    +  L  EK+  LL+K+S  + LV  +L E+LN  +W  R+  C +I+ L  P+NKD+  K++++MW+D    V+ AA+  L K    K +H EL TKL+      R +AL  IG L +MT  ++P FL+CF+D+   VRK+ C     L ++D   ++ L+ L + +PLW+VK  AI AL         ++  ++WA+  E +  +R+ A + +  + T   +    I+ R  +E +  +   +  +L +   +   D + + +IK +V+   +  DHII
Sbjct:  214 SALRYAVDKWRIACNVKLPECCQRGASWQGVTLKSLQRDLCDPNYQVRLEAIVTCASRAVHGPQQELDHGKAGQHWNRLKLKAITQKLLAIIIAALDDPVKRVRMAAAVCQYAMRMPNAHARDILLSMIKQDLSGAGTDSWVAAQCLAIEGNASQAVIQRLLSQHFLKDAPLDQEKSMMLLSKISSKTTLVRSLLAEELNNANWTARVQACNSIAKLKSPINKDVCTKLLHVMWNDWSCAVRHAAALALSKLDAAKEMHAELSTKLEEGPSARRVEALTFIGQLNIMTPTLLPTFLRCFNDDCEAVRKQACLTAASLMMKDQSVLDQLINLMQNEPLWEVKVDAINALGNIGWLNPALQELLMWAVHHEEEPGVRIAACEALNNLDTKGLQFQHFIEDRYTLEPNAEVKSHIECLLKKHGYSLQGDQSKMNDIKLQVKLMCT--DHII 659
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Xenopus
Match: ENSXETT00000011571.1 (HEAT repeat containing 4 [Source:NCBI gene;Acc:100495576])

HSP 1 Score: 216.083 bits (549), Expect = 1.160e-57
Identity = 189/628 (30.10%), Postives = 296/628 (47.13%), Query Frame = 2 
Query:  614 WDEYILSLMSQNTAQYLAYNLTKDENQADRLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSL--KEFQLPKTPPKS------VNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGK-IYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNL--------LVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTI---CVENLLQ 2437
            WDE++L  +++ TAQ++A + T +     +L++ +    G  SS  ELI ++                              ++  E  +P++ Q   K+R  +  +KEDN              T  +F  LPV       T KE    S N T  SL  K F+    P  S      +N K G  V  T+N ++ +LY    K   +      N I  + +  Y K+LQ + P   + T +ST+D +    L     +G  RW  LP      L K     EL    +   + +      L L        ++ QW+  W LT  + ++T+++L RD+  VH   R+ A+VT A +A     ++    NT  ++  + C+P  +   I   L D    VR AAA+  +     ++++  ++   L    + D WAA QCLA+       VI  +I QL    +    E+  Y+L K+S  +KLVH MLGE LN  +WR R++ C+ +S LHG  N+DL  K+ YLMW D    VK AA++ LG  G GK +H++L  KLQ  +   + +AL  IG L++MT +++P FL+CF DEF  VRK+ C A   L+I+D +   C+ +L+Q
Sbjct:  217 WDEHVLKKLTKTTAQWIAGHYTDNR----KLKKTLCKRDGLRSS-EELIREE------------------------------RMTEEDFRPYKEQE--KSREISDQSKEDN--------------TTDTF--LPVETPFPLLTKKEAIHGSYNKTAESLIVKHFE----PAPSLRLQDLMNPKAGKHVCATENAFEGELYSGLVKIMHQKGITNKNHIIMESQNQYDKHLQELLP--KSHTEWSTKDSEAGLPLRP--ERGAVRWIALPTPV---LNKTIQTCELPVDPKPQGQTQPEKEMHLKLNKRQVLWNILTQWKSSWMLTGNWKETTLEQLKRDLHSVHKNSRISALVTIATSAVRQSMEEADAGNTASKSTPTLCVPEDMC-LINNALGDVDALVRMAAALCCYINHSVSEEARKVMFSALEKGCDADSWAAAQCLALEGDHSYPVIKRIITQLFEVNNEETEEQGLYMLRKLSMGTKLVHAMLGEALNNGNWRDRVLACRALSQLHGHGNQDLRNKLNYLMWEDWSPAVKQAAARSLGIMGCGKEIHDQLQKKLQCGTWKTKVEALSLIGWLRLMTAQLLPEFLQCFSDEFAAVRKQACLAAGLLQIRDDVILSCLCDLIQ 779
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Mouse
Match: Heatr4 (HEAT repeat containing 4 [Source:MGI Symbol;Acc:MGI:4937307])

HSP 1 Score: 249.21 bits (635), Expect = 8.008e-68
Identity = 163/570 (28.60%), Postives = 298/570 (52.28%), Query Frame = 2 
Query: 1121 KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDH------SSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNE 2812
            + VN K G     TDN +++++YF+  +   ++  + D I+  +   Y K+L  ++P   T  ++S + + +   +   + KG  RWT LP   E  L++           RQ  + +  +       + L  ++ +W+  W L  ++   TV+ LLR +  ++  IR+QAI+T A AA      +   T    E +  D LP +L+  +E  L   +  VR AAA+  + ++     + +I++  LI  +++D WAA QCLA+   A   VI  ++ QL +  +    E+A  LL  +  +  L+H ML  +LN+  W+ R++ C+  S + G +  D+ +K+I LMW+D +K+V+ +A++ LG+   GK +H+ +  KL   +   R  AL  I +LK+MT +++P+FL CF DEF  +R+  C A   L+I+D + +E L+ L   DP WK+K +AI+AL +      ++ + +LWA+ +E    +RL A + I  +     ++ D      L+E  +++L+ +H+ +  +N+        + EIK++++   + KD +   IL  E
Sbjct:  347 RQVNRKAGEYAYATDNTFEQEMYFDGVRIVHQIGGRKDQIVLENLNRYDKHLTKVFP--ETPEKWSFQPIPE---MPYKLRKGVQRWTALPT--EASLLQVGKEATSAKTRRQKKQVQPVEEDVPWELAILRRMLQEWKTSWGLIIEWYHETVENLLRGIQSMYDDIRVQAIITCATAAL--ERPRIATTPENSEPIIVD-LPEVLLPVLEDALSHRNPNVRMAAAVCQYCIQSHNPTARDIMQTALIKGNSVDSWAAAQCLALEGIATYPVIKRILHQLFHKNNQATEEQACILLNHLRVNKTLIHTMLAVELNSRQWKDRIVACRAFSQITGKVCIDMKQKIIQLMWNDWNKEVRQSAAKALGRMNLGKEIHDMIRVKLCQGNSQERIKALSLIRVLKLMTAKLLPSFLTCFSDEFTGIRQAACLAAGALQIRDRMVLERLMNLMHTDPYWKIKAFAIRALGQIGLVSPQLTNKLLWAIHYEDSPGVRLEACRSILALKLHGAQVRDTFLDVLLLEKHEAVLKEIHQTMKALNLEKEGSQEMIQEIKKKIQT-LNQKDILTEKILKME 905
[Close]
BLAST of HEAT repeat-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q86WZ0|HEAT4_HUMAN (HEAT repeat-containing protein 4 OS=Homo sapiens OX=9606 GN=HEATR4 PE=2 SV=2)

HSP 1 Score: 264.618 bits (675), Expect = 9.714e-72
Identity = 184/622 (29.58%), Postives = 327/622 (52.57%), Query Frame = 2 
Query: 1001 FYRLPVLVRKTKKTNKEVNIESVNPTTRSLKE---FQLPKTPP--KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKA---DNALELENLERQNSRKRARDHSSLNLLV-----DQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTN---TVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAI 2818
            +YRLP   ++ +     V I   N +T  + E      P+T    + V  + G     TDN +++++YF+E +   ++  K D I+  +   Y K L  ++P   T  ++S + + ++        +G  RWT LP   ++ L++    D  ++   L++Q   K  ++  +  L+V      +W+  W L  ++   TV+ LL+ + D+H  +R++AI T A AA         Q +   T+Q+      LP +L+ A+E  L D +  VR AAAI  ++++     + NI++  L+  +++D WAA QCLA+  +A   VI  ++ QL   ++    E++  LL+ +S  + L+H ML  +LN+  W+ R++ C+  S + G +  D+  K+I LMW+D +K+V+ AA+Q LG+   GK VH+ +  KL   +   R +AL  IG LK+MT +++P+FL CF D+F  VR+  C A   L+I+D + +E LL L + DP WK+K +AI+AL +      E+   +LWA+ +E    +RL A + I  +      + D      L+E+  ++L+ +++ +  +N+    +   + EIK  + K  S KD + + IL  E +
Sbjct:  292 YYRLPSYFQQAET----VEIMPGNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQIIHQIGAKRDQIVLENLNRYNKQLSKVFP--ETPEKWSAQAIPEASYRPV---QGALRWTALPTPAKDMLLQVGEKDVPIKTRRLKKQA--KSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETVENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDSDKTIQD------LPEVLLPALEAALCDKNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNSVDSWAAAQCLALEGTATYPVIKRILHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNVCLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLIGELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIKAFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLLLENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRI-KTLSQKDLLTHKILKLEMV 895
[Close]
BLAST of HEAT repeat-containing protein 4 vs. TrEMBL
Match: A0A267H1R7 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000186g4 PE=4 SV=1)

HSP 1 Score: 460.685 bits (1184), Expect = 6.998e-137
Identity = 286/790 (36.20%), Postives = 432/790 (54.68%), Query Frame = 2 
Query:  614 WDEYILSLMSQNTAQYLA----YNLTKDENQADRLQRLVNNWYG-PPSSFRELIPDDSADKDPEEVRSDLKSIFPY----KYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQ---NDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPP-----KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDN-----IINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNA----------LELENLERQNSR----KRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQT-------NTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTL-DTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLI 2851
            WD+Y+L  +  NTA Y+A    +N        DRL+R    WYG  P    +L+PD          R DL    P      Y ++      +  +   +P      L +    L++ E +  +A +     DPYG+  +A+FYRLP+  RK  K ++ V+ +  N T  ++   +LP   P      S+N ++G+K   TDN Y++     E+ +  KL+++P N     + N++   Y   L P  P              D Q       +G  +W  LP  Q+++ +K               E+E+ E Q  R    KR R+   L+ +VD+WR+KW L  +Y D TV++LLRDM DVHPTIRLQA++T A      H Q+Y          +   E+  S  LP  L+ A+E+LL+D H QVR AAAI L+   K T ++  +L++ L++ S  DRWAAVQCLA   + DS VIG L+ +LM +ED L H   + LLA +S H+ LVHG+L E+LN+ SWR+R+I+CKT+  L+G LN+DL +K+ +LMW+D HK V+ +A++ LG+TG+GK VH++++ +L+   E IRADA+EK+G+L VMT R+MPAFL CF D++  VR   C AC  L+I+D  CV  LL+LA +DP WKVK  AI+A+       +++   +LWA +FE + ++R  A++ I     L D      ++ R LVE    +L  L   L  + ++P  D +TVA+IKE VRK    K  I   ++  E  E+++ L + +I
Sbjct:  247 WDDYVLRQLHPNTAAYVAREAVHNPVDRRAYVDRLKR----WYGQAPPDLVDLVPD----------RPDLTEYPPVPSPDHYLLEATADEARRKLRRNRPNSNAFRLSSPFLRLLDDERSREAAGEAVADTDPYGEANRAAFYRLPLGSRKRVKEDQAVSDDHGNSTAAAISS-ELPAKSPLPQLKDSMNPRVGDKCYTTDNDYER-----ERLSGVKLVHQPGNQKELLLQNYN--RYTLQLAPQVP--------------DEQGDGAKPKRGMRKWIGLPLAQDDNQIKGSRGKPTQHLNKLGSEVEDYEEQRRRLESSKRKRNDEHLHNVVDEWRRKWHLNSRYGDCTVEDLLRDMVDVHPTIRLQAVLTCA------HAQRYVAEADDAIHFDESAESATSSQLPQSLMTALELLLDDQHAQVRYAAAICLYQTNKPTPRAEALLRDCLVNGSGDDRWAAVQCLAGQGAFDSDVIGALVHELMTNEDTLRHHVTTQLLASLSQHTPLVHGLLAEQLNSPSWRRRVIVCKTLPTLNGSLNRDLAQKLSHLMWNDSHKAVRRSAAKALGQTGHGKDVHDDILRRLRESGERIRADAVEKLGLLGVMTGRLMPAFLACFDDQYASVRIAACVACSRLRIRDEQCVRGLLRLAAHDPWWKVKARAIQAIGLIGLVSTDVAETLLWAARFEPEERVRATAVRTIALQLRLRDEPAKQALRDRLLVEKSPLVLEQLRLGLQAMGLSPTADGDTVAQIKEAVRK-LDEKGRICREVMEAERAEEFSDLHQRMI 993
[Close]
BLAST of HEAT repeat-containing protein 4 vs. TrEMBL
Match: A0A267GXT1 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000186g1 PE=4 SV=1)

HSP 1 Score: 452.981 bits (1164), Expect = 4.128e-136
Identity = 284/781 (36.36%), Postives = 430/781 (55.06%), Query Frame = 2 
Query:  614 WDEYILSLMSQNTAQYLA----YNLTKDENQADRLQRLVNNWYG-PPSSFRELIPDDSADKDPEEVRSDLKSIFPY----KYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQ---NDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPP-----KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFS---TEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSR----KRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYG-------QTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTL-DTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLIGTS 2860
            WD+Y+L  +  NTA Y+A    +N        DRL+R    WYG  P    +L+PD          R DL    P      Y ++      +  +   +P      L +    L++ E +  +A +     DPYG+  +A+FYRLP+  RK  K ++ V+ +  N T  ++   +LP   P      S+N ++G+K   TDN +++     E  +  KL+++P N      ++ ++N            R++    + V D Q       +G  +W  LP  Q+          E E+ E Q  R    KR R+   L+ +VD+WR+KW L  +Y D TV++LLRDMADVHPTIRLQA++T A      H Q+Y          +   E+  S  LP  L+ A+E+LL+D H QVR AAAI L+   K T ++  +L++ L++ S  DRWAAVQCLA   + DS VIG L+ +LM +ED L H   + LLA +S H+ LVHG+L E+LN+ SWR+R+I+CKT+  L+G LN+DL +K+ +LMW+D HK V+ +A++ LG+TG+GK VH++++ +L+   E IRADA+EK+G+L VMT R+MPAFL CF D++  VR   C AC  L+I+D  CV  LL+LA +DP WKVK  AI+A+       +++   +LWA +FE + ++R  A++ I     L D      ++ R LVE    +L  L   L  + ++P  D +TVA+IKE VRK    K  I   ++  E  E+++ L + +I  S
Sbjct:  250 WDDYVLRQLHPNTAAYVAREAVHNPVDRRAYVDRLKR----WYGQAPPDLVDLVPD----------RPDLTEYPPVPSPDHYLLEATADEARRKLRRNRPNSNAFRLSSPFLRLLDDERSREAAGEAVADTDPYGEANRAAFYRLPLGSRKQVKEDQAVSDDHGNSTAAAISS-ELPAKSPLPQLKDSMNPRVGDKCYTTDNDFER-----EWLSGVKLVHQPGN----QKELLLQNY----------NRYTLQLAQQVPDEQGDGAKPKRGIRKWIGLPLAQDPTQHLNKLGSEEEDYEEQRRRLESSKRKRNDEHLHNVVDEWRRKWHLNSRYGDCTVEDLLRDMADVHPTIRLQAVLTCA------HAQRYVAEADDAIHFDESAESATSSQLPQSLMTALELLLDDQHAQVRHAAAICLYQTNKPTPRAEALLRDCLLNGSGDDRWAAVQCLAGQGAFDSDVIGALVHELMTNEDTLRHHVTTQLLASLSQHTPLVHGLLAEQLNSPSWRRRVIVCKTLPTLNGSLNRDLAQKLSHLMWNDSHKAVRRSAAKALGQTGHGKDVHDDILRRLRESGERIRADAVEKLGLLGVMTGRLMPAFLACFDDQYASVRIAACVACSRLRIRDEQCVRGLLRLAAHDPWWKVKARAIQAIGLIGLVSTDVAETLLWAARFEPEERVRATAVRTIALQLRLRDEPAKQALRDRLLVEKSPLVLEQLRLGLQAMGLSPTADGDTVAQIKEAVRK-LDEKGRICREVMEAERAEEFSDLHQRMIPKS 989
[Close]
BLAST of HEAT repeat-containing protein 4 vs. TrEMBL
Match: A0A267GKD8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000186g3 PE=4 SV=1)

HSP 1 Score: 448.358 bits (1152), Expect = 1.742e-132
Identity = 284/782 (36.32%), Postives = 429/782 (54.86%), Query Frame = 2 
Query:  614 WDEYILSLMSQNTAQYLA----YNLTKDENQADRLQRLVNNWYG-PPSSFRELIPDDSADKDPEEVRSDLKSIFPY----KYYMDKIKSADKLPVEP-VKPFQVQPTLKTRICNLVNKEDNLHSATDQ---NDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPP-----KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFS---TEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSR----KRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQT-------NTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTL-DTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLIGTS 2860
            WD+Y+L  +  NTA Y+A    +N        DRL+R    WYG  P    +L+PD          R DL    P      Y ++      +  +      F+    L +    L++ E +  +A +     DPYG+  +A+FYRLP+  RK  K ++ V+ +  N T  ++   +LP   P      S+N ++G+K   TDN Y++     E+ +  KL+++P N      ++ ++N            R++    + V D Q       +G  +W  LP  Q+          E E+ E Q  R    KR R+   L+ +VD+WR+KW L  +Y D TV++LLRDMADVHPTIRLQA++T A      H Q+Y          +   E+  S  LP  L+ A+E+LL+D H QVR AAAI L+   K T ++  +L++ L++ S  DRWAAVQCLA     DS VIG L+ +LM +ED L H   + LLA +S H+ LVHG+L E+LN+ SWR+R+I+CKT+  L+G LN+DL +K+ +LMW+D HK V+ +A++ LG+TG+GK VH++++ +L+   E IRADA+EK+G+L VMT R+M AFL CF D++  VR   C AC  L+I+D  CV  LL+LA +DP WKVK  AI+A+       +++   +LWA +FE + ++R  A++ I     L D      ++ R LVE    +L  L   L  + ++P  D +TVA+IKE VRK    K  I   ++  E  E+++ L + +I  S
Sbjct:  251 WDDYVLRQLHPNTAAYVAREAVHNPVDRRAYVDRLKR----WYGQAPPDLVDLVPD----------RPDLTEYPPVPSPDHYLLEATADEARRKLRRNSNAFR----LSSPFLRLLDDERSREAAGEAVADTDPYGEANRAAFYRLPLGSRKRVKEDQAVSDDHGNSTAAAISS-ELPAKSPLPQLKDSMNPRVGDKCYTTDNDYER-----ERLSGVKLVHQPGN----QKELLLQNY----------NRYTLQLAQQVPDEQGDGAKPKRGMRKWIGLPLAQDPTQHLNKLGSEEEDYEEQRRRLESSKRKRNDEHLHNVVDEWRRKWHLNSRYGDCTVEDLLRDMADVHPTIRLQAVLTCA------HAQRYVAEADDAIHFDESAESATSSQLPQSLMTALELLLDDQHAQVRHAAAICLYQTNKPTPRAEALLRDCLVNGSGDDRWAAVQCLAGQGDFDSDVIGALVHELMTNEDTLRHHVTTQLLASLSQHTPLVHGLLAEQLNSPSWRRRVIVCKTLPTLNGSLNRDLAQKLSHLMWNDSHKAVRRSAAKALGQTGHGKDVHDDILRRLRESGERIRADAVEKLGLLGVMTGRLMSAFLACFDDQYASVRIAACVACSRLRIRDEQCVRGLLRLAAHDPWWKVKARAIQAIGLIGLVSTDVAETLLWAARFEPEERVRATAVRTIALQLRLRDEPAKQALRDRLLVEKSPLVLEQLRLGLQAMGLSPTADGDTVAQIKEAVRK-LDEKGRICREVMEAERAEEFSDLHQRMIPKS 987
[Close]
BLAST of HEAT repeat-containing protein 4 vs. TrEMBL
Match: R7V5D5 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_220456 PE=4 SV=1)

HSP 1 Score: 420.624 bits (1080), Expect = 2.041e-122
Identity = 304/909 (33.44%), Postives = 463/909 (50.94%), Query Frame = 2 
Query:  239 LLKKFPNTINKEKNNLESILNDLKFSYEVAAERCSYLLPYDEKFYESVYNFPRTVKKIKKRKCYSDKH----------FCHSMSNVTEYIPLPPVGKPELFLIKSQE-------KGLNNKI--------------ICQDPIEVVATEKELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQADRLQRLVNNWYGP-PSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKK--TNKEVNIE---SVNPTTRSLK--EFQLPKTPP--KSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSS---------LNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYG-QTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNE 2812
            L KK   + NK  N +    + L F  +V  +RC +L PYD+K+     +F   +    K      +H           CH    V+    L P+ +    L K++E       K   NKI                 +P    A  +  H+ +  WD Y+LS +S +TAQ+L           + LQ  +   YGP      +LI D  ++ +     +D  S +         K  D L ++ V+   VQ  L T                   DPY D+T A FYRLP   R+ KK    ++   E   ++N TT +++   ++ P   P   SVN K  + + KT+N Y+++ + +  K   +  +  D I+      Y K L    P ++ +    +      +       +G +RW +LP    E +      LE+     +    ++ DHS          L  +++ WR KW L  +Y D+T D+L+RDMAD+HP IRL+AI T A+AA      + G Q +  +E+ N   LP  L  A+E  L+D H QV++AAAIAL+SLE  T KS +IL+  L  + + DRW A QCLA     DS V+GELI QL++SED + HE+++ LL K+S +S LVH ML E+LN+ SWR R++ CK I  L+G +N+DL +K+ YLMW+D H +V+  A+Q LG+TG+GK VH+EL+ K+ +  E IR +A+ KIG L +MT +++P FL CF D +V VR E CRAC  LK+ D   +  L+  A YDP+WKVK  AI+AL +       IR+C+LWA ++E +  +R  A   I  +     +I   ++ R LVE+++ + R + + L  ++I P  D++ V ++KEEVRK F+ + H+   I T E
Sbjct:   56 LAKKLKLSTNK--NYVRDASSGLSFEEDVVRDRCFHLTPYDKKYLNEALDFSSLISLPPKASIAPGRHNQRGVDKRHMPCHLKKRVSHQ--LKPIKRK--ILEKAKEMNKDAEIKAERNKIALTGSEDTDSYQSTFLTEPCSPRAARR--HEPQLEWDRYLLSNLSMSTAQWLVKQRMGSGTNKEELQEFLVKNYGPLQEGDVDLIQDSLSEVEMPVQTADQGSGW--------RKREDTL-LDRVRELTVQDELPT-------------------DPYADETAAPFYRLPAGFRRAKKFVAKEQEGSEMEGAINSTTHNIEVIPYEAPPFHPLEDSVNPKARDALYKTENPYEQE-WLSGVKQVHQKSDSKDYIMMDSQNKYKKFLVKESPAKVDTWYQPSPPKSGQKEKMKKFERGLHRWQKLP----EAIDDVGTELEICPPVTKPRSIKSPDHSDKKEIQSNHLLTQIIEDWRGKWYLDMRYGDATPDDLIRDMADLHPHIRLKAITTCARAAEYKPPPELGIQLDETKES-NVGLLPDELFAALECCLDDEHEQVQRAAAIALYSLEHPTLKSESILRRTLQQEQSADRWTAAQCLAYFGECDSEVVGELIYQLLHSEDAIRHEQSTKLLTKLSENSTLVHSMLAEQLNSCSWRHRVMACKIIPKLYGHINRDLTQKIAYLMWNDWHNEVRKVAAQTLGRTGHGKDVHDELLDKISNGGEKIRMEAVSKIGYLGIMTAKLLPVFLDCFEDNYVSVRMECCRACSNLKMDDPEILRRLIHSATYDPIWKVKALAIQALGRIGVLNEVIRNCVLWAFRYEDQAGVRAEACHTIIRLQIKGKDIGQALQDRYLVETNEIVKREIIEGLAMLDILPSEDMDMVTQVKEEVRKLFT-RGHVCAQITTIE 921
[Close]
BLAST of HEAT repeat-containing protein 4 vs. TrEMBL
Match: V4AZA5 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_238549 PE=4 SV=1)

HSP 1 Score: 408.297 bits (1048), Expect = 4.769e-118
Identity = 290/928 (31.25%), Postives = 475/928 (51.19%), Query Frame = 2 
Query:  236 LLLKKFPNTINKEKNNLESILNDLKFSYEVAAERCSYLLPYDEKFYESVYNFPRTVKKIKKRKCY--------SDKHFCHSMSNVTEYIPLPPVGKP--------------------------------ELFLIKSQEKGLNN----KIICQDPIEVVATEKELHQSRRHWDEYILSLMSQNTAQYLAY----NLTKDENQADRLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLK----EFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEE--DLMKA--DNALELENLERQNSRKRARDHS-SLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYG--------QTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIED 2824
            +LL+ F  T  K+      I  DL F+ +V  +RC ++LPY +K++    +    + K  KR           SDK     +   T+Y  L P+ K                                  +FL +  +K   +    KI     +E+    +E ++ +  WD Y++S++S  TA ++ +     +    ++ + L +L+  WYG P    +LI DD +D DP      + +    K+     K  + + +E V               L N E+   +     DPY D+ +A FYR PV  RK KK  ++  + ++N T R ++    +   P T     N K G  +++TDN ++++ +    +   +  +    I+  +   Y+K LQ  +P        + E+ +D++      +KG  RW  LP   ++  D++K        +  +      K+ +  + +L+ ++D+WR KWQL+ ++ DS   +LLRDMAD+ P +RL+AI T AK+      ++ G        Q + V        LP  L +A+  LLED H QV+KAAA+ L++L K +DK+  +L+ELL+S+S  DRW A QCLA     DS V GE+I QL+ +ED + HE+   LLAK+S  + L+H M+ E+LN+ SWR R+I CK    L G +NKD+  K+ +LMW D H +V+  A+Q LGKTG+G++VH++L  K+Q   E ++ +A+ +IG L +MT +++P  L CF DE+  VR EVC  C  L IQD   ++ LL LA +D +WKVK  A++AL K       I+ C+ WAL++E +  +R  A   + T+     + ++I++ R LVE +  +   + K LN + I+   DI+TVA+IK EVRK   ++  I ++IL+N+  E+
Sbjct:   57 VLLRPFGKTYIKD------ICGDLSFTEDVVRDRCFHMLPYSDKYFYEALDVSSLIPKQPKRNILIGRHNTSGSDKRHMPCIPTKTQY--LKPLRKKISDKALEMHQEAVEKQRSESQASLNTLDSQDDPVFLTEVDDKQSKSTKLPKINKDKHVELSHEAEEGNEKKHDWDAYLMSIISPLTANWIVHQKMTGVGGVTSEKEELSKLLEGWYGKPE-HTDLIRDDISDTDP------VTTPTAEKHKKKVWKKEESILLEKV---------------LQNNEEEPKA----RDPYSDNNEAPFYRQPVGFRKQKKKIEKEELGAINSTARDIEVKTYKPPPPPTLRDYFNPKAGETLIQTDNVFERE-WLTGNEQVYQGESDSQQIVMANQNKYIKQLQIAYPDVEKWCPRNEENQEDTEQFIIP-SKGARRWKSLPKPVDDTRDVLKCLPPGTEPVPVIPSDAKTKKVKQQNPALSQIIDEWRSKWQLSGQFADSNPHDLLRDMADIQPHVRLKAIATVAKSTEYKAPEEDGILLEYQDQQIDAVSR------LPEFLFDALNCLLEDKHEQVKKAAAVTLYTLNKPSDKAEAVLRELLLSESPSDRWTAAQCLAHFGVCDSDVAGEVITQLLATEDSIKHEQCKQLLAKMSASTTLIHSMVAEQLNSSSWRHRVIACKIFPALDGTINKDIANKLAHLMWKDWHVEVRKVAAQTLGKTGHGRSVHDDLKEKIQGSDERLKQEAISRIGHLGIMTAKLLPVILDCFDDEYNSVRMEVCITCGNLMIQDQQVIDKLLYLATFDTVWKVKALAMQALGKIGVSSPAIKECLTWALRYEKEGGVRAEACHTLTTLEYTGDDFIEILQERLLVEEEAIVRNEISKALNLLGISSSDDIDTVAQIKCEVRK-LCDQGTIASMILSNDKNEE 941
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Nematostella
Match: EDO48699 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIG1])

HSP 1 Score: 257.299 bits (656), Expect = 3.452e-70
Identity = 185/645 (28.68%), Postives = 317/645 (49.15%), Query Frame = 2 
Query: 1100 QLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNII-------NFDGKI---YVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLE------RQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQK-----YGQTNTVQETVN----SDCLPPILVNAIEIL---------------------------------LEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLIGTS 2860
            +L  TP  ++ S++G+K L T N YQ +L    +    K  +  + I+        F   +   + +  +P +P +    +   +         +  TKG +RW +LP+  ++D++ A       +++          RK+ ++  ++  + ++WR KW L +++ +ST +EL++ M D++  +RL A+   +KAA I   +K      G      E        DC+  ++V  +  L                                 L D + QVR AAAI L++L K +D++  +L   +      ++WAA QCLA++ +    VI EL+ QL +   +   E A  LLA++S +S +VH ++ E LN+ SW+ R+   K I  L G +NKD+ +K+ YLMW+D  K V+ AA+Q LGKTGNGK VH+ L  ++ + +E  + DAL+K+  L +MT R++PA + CF  E+V VR E   A   L+I D   ++ LL +A  D  WKVK +AIKAL         +   +LWA+++E    +R  A   +  +   D  ++ +++ R +VESD  + R     L  + + P  D+  +  I+ EV +  + +D ++  IL  +    Y    + L  TS
Sbjct:  316 ELNYTPSFTLPSRVGDKKLDTQNVYQLELLAGAQPIPAKKHSDKNTIVLGSNEQVKFQKHLQDNFPQGAKPWFPAKGKKKKIYNQ--------VSRQTKGLHRWKELPSVIQDDILLATKTSSHSDVDIATISAGYKLRKKIKEDLNVVKIAEEWRSKWFLERRWQNSTTEELMKGMVDINDHVRLSAVAACSKAAMIRKAKKEQPKLQGDIVVGLERCGMDGPEDCVVRLVVWGVAGLESVKWVVLDKGKDTEIPLQAALEPELLDRVNKLLHDKNCQVRIAAAITLYTLNKKSDEAEKVLLWAIEHGGGPEKWAATQCLAMAGTVCDRVINELVRQLHSDNSVRTIE-AGALLAELSQYSGIVHSLIAELLNSNSWKDRVTASKVIPKLRGVINKDMTQKLSYLMWNDWSKDVRSAAAQALGKTGNGKLVHDTLRERIMTGNERAQVDALKKLSNLGIMTVRLLPALIDCFRSEYVSVRIEAAMAAGQLRITDDKLLKGLLDMASNDRSWKVKAHAIKALGCVGIVTERVIDVLLWAIRYEKVAAVRAEACNAVAALRIRDERMLSVLQDRLVVESDDLVKREAIFTLQTLGVEPTGDLEMIEAIRTEVHRLCT-RDLVVAHILEEDNAHAYTSDYKRLFTTS 950
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Nematostella
Match: EDO29490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T3H5])

HSP 1 Score: 106.686 bits (265), Expect = 2.813e-26
Identity = 56/160 (35.00%), Postives = 89/160 (55.62%), Query Frame = 2 
Query: 2201 TGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEFVLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQTCISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVESDKSILRT 2680
            T NGK VH+ L  ++ + +E  + DAL+K+  L +MT R++PA + CF  E+V VR E   A   L+I D   +E LL +A  D  WKVK +AIKAL         +   +LWA+++E    +R  A   +  +   D  ++ +++ R +VESD  + R+
Sbjct:   21 TMNGKLVHDTLRERIMTGNERAQVDALKKLSNLGIMTVRLLPALIDCFRSEYVSVRIEAAMAAGQLRITDDKLLEGLLDMASNDRSWKVKAHAIKALGCVGIVTERVIDVLLWAIRYEKVAAVRAEACNAVAALRIRDERMLSVLQDRLVVESDDLVKRS 180
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Planmine SMEST
Match: SMESG000024852.1 (SMESG000024852.1)

HSP 1 Score: 1148.27 bits (2969), Expect = 0.000e+0
Identity = 580/586 (98.98%), Postives = 582/586 (99.32%), Query Frame = 2 
Query:  575 VATEKELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQADRLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAF 2332
            +ATE ELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQA+RLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEKKNQKKLLNKPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVD SQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDM DVHPTIRLQAIVTAAKAATIIHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHG LNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAF
Sbjct:    1 MATENELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQANRLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEKKNQKKLLNKPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDASQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMTDVHPTIRLQAIVTAAKAATIIHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGSLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAF 586
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Planmine SMEST
Match: SMESG000024852.1 (SMESG000024852.1)

HSP 1 Score: 1078.93 bits (2789), Expect = 0.000e+0
Identity = 546/552 (98.91%), Postives = 548/552 (99.28%), Query Frame = 2 
Query:  575 VATEKELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQADRLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEXXXXXXXXXXPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIRLQXXXXXXXXXXXXHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEE 2230
            +ATE ELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQA+RLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEKKNQKKLLNKPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVD SQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDM DVHPTIRLQAIVTAAKAATIIHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHG LNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEE
Sbjct:    1 MATENELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQANRLQRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSADKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFYRLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVLKTDNQYQKDLYFNEKKNQKKLLNKPDNIINFDGKIYVKNLQPIWPCQITSTRFSTEDVDASQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLERQNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMTDVHPTIRLQAIVTAAKAATIIHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPHFQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSADSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAISWRQRLIICKTISLLHGSLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTGNGKAVHEE 552
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Planmine SMEST
Match: SMESG000024853.1 (SMESG000024853.1)

HSP 1 Score: 452.981 bits (1164), Expect = 3.814e-149
Identity = 295/326 (90.49%), Postives = 298/326 (91.41%), Query Frame = 2 
Query: 2600 MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLIGTSNQFKQFKQFNENSEELQTVXXXXXXXXXXXXXXXXXXQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKXXXXXXXXXVKEDLTNSPVAMPNNNAFGEEILETQKFIDNETVINDSGGIIKETKRLSSVSNDLINDPGSIDTNRGFDIENGEFSDELDMIETEDGSKEIKISTKEFEIDRGKPVESETXXXXXXXXXXXXXXXXXXXXXXXXHDKSKEIKCDSNESEIDKEKYPED 3577
            MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINP VDINTVAEIKEEVR                  IEDYNFLKETLIGTSNQFKQF   NENSEELQTVSEFSDSESEDNSTNEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIVKEDLTNSPVAMPNNNAFGEEILETQKFIDNET+INDSGGIIKETKRLSSVSNDLINDPGSID N GFDIENGEFSDELDMIETEDGSKEI  STKEFEIDR KPVESETI NENESEKLEKEENFNKS+NIEI+DKSKEIKCDSNESEIDKEKYPED
Sbjct:    1 MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPAVDINTVAEIKEEVR-----------------TIEDYNFLKETLIGTSNQFKQF---NENSEELQTVSEFSDSESEDNSTNEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIVKEDLTNSPVAMPNNNAFGEEILETQKFIDNETIINDSGGIIKETKRLSSVSNDLINDPGSIDINIGFDIENGEFSDELDMIETEDGSKEINNSTKEFEIDREKPVESETINNENESEKLEKEENFNKSENIEIYDKSKEIKCDSNESEIDKEKYPED 306
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Planmine SMEST
Match: SMESG000024853.1 (SMESG000024853.1)

HSP 1 Score: 446.432 bits (1147), Expect = 1.003e-146
Identity = 292/326 (89.57%), Postives = 296/326 (90.80%), Query Frame = 2 
Query: 2600 MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLIGTSNQFKQFKQFNENSEELQTVXXXXXXXXXXXXXXXXXXQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKXXXXXXXXXVKEDLTNSPVAMPNNNAFGEEILETQKFIDNETVINDSGGIIKETKRLSSVSNDLINDPGSIDTNRGFDIENGEFSDELDMIETEDGSKEIKISTKEFEIDRGKPVESETXXXXXXXXXXXXXXXXXXXXXXXXHDKSKEIKCDSNESEIDKEKYPED 3577
            MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINP VDINTVAEIKEEVR                    +YNFLKETLIGTSNQFKQF   NENSEELQTVSEFSDSESEDNSTNEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIVKEDLTNSPVAMPNNNAFGEEILETQKFIDNET+INDSGGIIKETKRLSSVSNDLINDPGSID N GFDIENGEFSDELDMIETEDGSKEI  STKEFEIDR KPVESETI NENESEKLEKEENFNKS+NIEI+DKSKEIKCDSNESEIDKEKYPED
Sbjct:    1 MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPAVDINTVAEIKEEVR--------------------NYNFLKETLIGTSNQFKQF---NENSEELQTVSEFSDSESEDNSTNEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIVKEDLTNSPVAMPNNNAFGEEILETQKFIDNETIINDSGGIIKETKRLSSVSNDLINDPGSIDINIGFDIENGEFSDELDMIETEDGSKEINNSTKEFEIDREKPVESETINNENESEKLEKEENFNKSENIEIYDKSKEIKCDSNESEIDKEKYPED 303
[Close]
BLAST of HEAT repeat-containing protein 4 vs. Planmine SMEST
Match: SMESG000024853.1 (SMESG000024853.1)

HSP 1 Score: 427.172 bits (1097), Expect = 1.568e-139
Identity = 285/326 (87.42%), Postives = 288/326 (88.34%), Query Frame = 2 
Query: 2600 MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILTNEAIEDYNFLKETLIGTSNQFKQFKQFNENSEELQTVXXXXXXXXXXXXXXXXXXQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKXXXXXXXXXVKEDLTNSPVAMPNNNAFGEEILETQKFIDNETVINDSGGIIKETKRLSSVSNDLINDPGSIDTNRGFDIENGEFSDELDMIETEDGSKEIKISTKEFEIDRGKPVESETXXXXXXXXXXXXXXXXXXXXXXXXHDKSKEIKCDSNESEIDKEKYPED 3577
            MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINP VDINTVAEIKEE                            ETLIGTSN   QFKQFNENSEELQTVSEFSDSESEDNSTNEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIVKEDLTNSPVAMPNNNAFGEEILETQKFIDNET+INDSGGIIKETKRLSSVSNDLINDPGSID N GFDIENGEFSDELDMIETEDGSKEI  STKEFEIDR KPVESETI NENESEKLEKEENFNKS+NIEI+DKSKEIKCDSNESEIDKEKYPED
Sbjct:    1 MPTLDTEIVDIIKSRCLVESDKSILRTLHKILNRVNINPAVDINTVAEIKEE----------------------------ETLIGTSN---QFKQFNENSEELQTVSEFSDSESEDNSTNEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIVKEDLTNSPVAMPNNNAFGEEILETQKFIDNETIINDSGGIIKETKRLSSVSNDLINDPGSIDINIGFDIENGEFSDELDMIETEDGSKEINNSTKEFEIDREKPVESETINNENESEKLEKEENFNKSENIEIYDKSKEIKCDSNESEIDKEKYPED 295
The following BLAST results are available for this feature:
BLAST of HEAT repeat-containing protein 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
HEATR42.023e-7229.58HEAT repeat containing 4 [Source:HGNC Symbol;Acc:H... [more]
HEATR42.023e-7229.58HEAT repeat containing 4 [Source:HGNC Symbol;Acc:H... [more]
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
si:dkey-13p1.33.287e-5029.91si:dkey-13p1.3 [Source:ZFIN;Acc:ZDB-GENE-131121-47... [more]
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSXETT00000011571.11.160e-5730.10HEAT repeat containing 4 [Source:NCBI gene;Acc:100... [more]
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Heatr48.008e-6828.60HEAT repeat containing 4 [Source:MGI Symbol;Acc:MG... [more]
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BLAST of HEAT repeat-containing protein 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 1
Match NameE-valueIdentityDescription
sp|Q86WZ0|HEAT4_HUMAN9.714e-7229.58HEAT repeat-containing protein 4 OS=Homo sapiens O... [more]
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BLAST of HEAT repeat-containing protein 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267H1R76.998e-13736.20Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A267GXT14.128e-13636.36Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A267GKD81.742e-13236.32Uncharacterized protein OS=Macrostomum lignano OX=... [more]
R7V5D52.041e-12233.44Uncharacterized protein OS=Capitella teleta OX=283... [more]
V4AZA54.769e-11831.25Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO486993.452e-7028.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO294902.813e-2635.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of HEAT repeat-containing protein 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of HEAT repeat-containing protein 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000024852.10.000e+098.98SMESG000024852.1[more]
SMESG000024852.10.000e+098.91SMESG000024852.1[more]
SMESG000024853.13.814e-14990.49SMESG000024853.1[more]
SMESG000024853.11.003e-14689.57SMESG000024853.1[more]
SMESG000024853.11.568e-13987.42SMESG000024853.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002145 ID=SMED30002145|Name=HEAT repeat-containing protein 4|organism=Schmidtea mediterranea sexual|type=transcript|length=3897bp
GAAATCAAAATTAAACTTAATGATCCGTTTGTTTTTTTAAATCGATCATA
ATAAAACTATGGTAATTAATTAGTATGAATTTCAAATTTAATTATAAAAT
TTCTCGATGACTACGAAAGAAAATCAACAGAAAAATTGCAATAAAATAGG
ACGTGAATATTTCAATGTTTCTTCTTTCACTAGTGAAACCCGGGATCTGT
TACTCAAGCCGGAAAACGGCAATACAAATGAGTTATTGCTGTTAAAAAAG
TTTCCAAACACCATCAACAAAGAAAAAAATAATTTAGAATCCATTTTGAA
CGATCTCAAATTCTCCTATGAGGTGGCAGCAGAACGATGCTCATATTTGT
TACCATATGATGAAAAATTCTACGAATCAGTTTATAATTTTCCAAGAACG
GTTAAAAAAATAAAAAAACGGAAATGCTATTCCGATAAACATTTCTGCCA
CTCGATGTCGAACGTCACTGAATACATCCCTTTGCCCCCTGTAGGGAAAC
CAGAACTGTTCTTAATTAAGTCGCAGGAGAAAGGATTAAATAACAAAATA
ATATGCCAGGACCCGATTGAAGTAGTGGCAACCGAGAAAGAATTACATCA
ATCGAGGAGACATTGGGATGAATACATCCTCTCGCTAATGTCCCAGAATA
CAGCACAATATCTTGCTTACAATTTGACCAAGGATGAGAATCAAGCCGAC
CGATTGCAGAGACTTGTCAACAACTGGTATGGGCCTCCTTCCTCATTTCG
GGAGCTTATTCCAGATGATTCGGCTGATAAAGATCCAGAAGAGGTCAGAT
CAGATTTGAAATCGATTTTCCCATACAAATATTACATGGACAAGATCAAA
TCAGCTGATAAACTGCCAGTTGAACCTGTAAAACCTTTTCAAGTTCAGCC
CACTCTCAAAACGAGAATCTGCAATTTAGTAAATAAAGAGGATAACTTAC
ATTCTGCGACAGATCAAAATGATCCGTACGGTGACGATACAAAGGCATCA
TTTTACCGACTGCCAGTTCTAGTTAGAAAAACAAAAAAGACAAACAAAGA
AGTAAACATCGAATCAGTAAATCCAACGACTCGGTCATTAAAAGAATTTC
AGCTTCCGAAAACTCCACCGAAATCCGTGAACTCAAAGCTGGGAAACAAG
GTGCTTAAAACCGATAACCAATATCAAAAAGACTTGTATTTTAACGAAAA
GAAAAACCAGAAAAAACTACTCAATAAACCGGACAATATTATAAATTTTG
ACGGTAAAATTTACGTTAAAAATTTACAACCAATATGGCCGTGTCAGATC
ACGTCAACTCGATTTTCTACTGAGGATGTCGATGATAGCCAATTACTAGA
AACTGGAATAACCAAAGGACAAAACAGATGGACCCAGCTTCCAAACAAAC
AGGAGGAAGATCTCATGAAAGCTGATAATGCCTTGGAACTAGAAAACCTA
GAACGTCAAAATAGTAGGAAACGAGCTCGTGACCATTCTTCATTGAATTT
GCTAGTCGACCAATGGAGAAAGAAATGGCAACTTACACAAAAATATGTTG
ATAGCACAGTTGACGAGTTATTGCGAGACATGGCAGATGTACACCCCACA
ATTAGGCTACAGGCGATTGTTACGGCTGCCAAAGCTGCGACTATTATTCA
CAATCAAAAATATGGCCAAACAAATACCGTACAAGAAACTGTTAATTCAG
ACTGTTTACCCCCAATTCTAGTAAACGCCATTGAAATACTATTGGAAGAT
CCACATTTCCAAGTCCGTAAGGCAGCAGCTATAGCCCTTCATTCTTTAGA
AAAATCCACCGACAAATCCCTGAATATACTAAAAGAGCTCCTAATATCAG
ACTCTAATATTGACCGATGGGCGGCTGTCCAGTGCTTGGCAGTTTCTAGT
AGTGCCGACAGTTTCGTTATTGGGGAGCTTATTGACCAGTTAATGAACTC
AGAGGACATTTTGGTACACGAAAAAGCGTCTTATTTATTAGCTAAAGTCA
GTTATCATTCGAAACTGGTCCATGGAATGCTCGGCGAGAAATTAAATGCA
ATTTCTTGGAGACAAAGACTTATAATTTGTAAAACAATATCACTTTTACA
CGGGCCTTTGAATAAGGACCTTATGCGAAAGGTTATCTACCTAATGTGGC
ATGATCCGCATAAACAAGTAAAAATAGCTGCTAGTCAGGTGTTGGGAAAA
ACCGGAAATGGAAAAGCAGTCCATGAAGAGTTAATCACAAAACTACAAAG
CGATTCGGAACTCATCCGAGCTGATGCTTTGGAGAAAATAGGAATTTTAA
AAGTTATGACAACTAGAATAATGCCAGCATTTTTAAAATGTTTTCACGAC
GAGTTTGTTTTAGTTCGAAAGGAGGTTTGCCGTGCTTGCTATTATTTAAA
AATACAAGACACGATTTGCGTGGAAAATCTTCTCCAACTGGCCAGATACG
ACCCGTTATGGAAGGTGAAATTCTACGCCATTAAAGCTTTGAGTAAAGCC
CAAACATGCATTTCAGAGATCCGATCATGCATTCTTTGGGCACTCCAGTT
TGAATCTAAAGTTCAGCTTCGACTGGTGGCCCTGCAAGTCATTGGGACCA
TGCCGACTTTAGACACCGAAATAGTGGATATCATTAAATCTCGATGTTTA
GTGGAAAGTGATAAAAGTATTTTAAGAACTCTCCATAAAATACTGAACCG
AGTCAACATAAATCCGGTAGTTGACATAAATACAGTCGCGGAAATTAAAG
AAGAAGTTAGGAAGTTCTTTTCGAATAAAGACCATATAATTAATGTGATT
CTTACCAATGAAGCGATTGAAGATTATAATTTCCTAAAGGAAACTCTAAT
TGGTACAAGCAATCAATTCAAACAATTCAAACAATTCAATGAAAACTCAG
AAGAGCTTCAAACAGTTTCAGAATTTTCTGATTCGGAATCAGAGGACAAT
TCGACAAATGAGGACTCAGAGCAACTCAATAGAGATCTAGCCTTATCGCC
AAGGAAAAGTCAAATTGATGAAGCCATAGTAGAAACTGAAGAAAAACATG
TTAATTCAAAAGTAAATTCAACCAAGGATGACATTGATATTATATCTGAC
ATAGTAAAAGAAGATTTGACCAATTCACCTGTTGCAATGCCCAATAATAA
CGCTTTTGGAGAAGAAATTCTGGAAACTCAAAAGTTTATTGATAATGAGA
CTGTCATAAATGATTCCGGTGGTATAATCAAGGAAACAAAAAGGTTAAGT
AGTGTCTCAAATGACCTTATCAATGATCCTGGATCCATTGATACAAATAG
AGGGTTTGATATTGAAAACGGTGAATTTTCTGATGAACTGGATATGATTG
AAACTGAAGACGGAAGTAAAGAAATAAAAATTTCTACAAAAGAATTTGAA
ATTGATAGAGGAAAACCTGTCGAATCAGAAACTATCAAAAATGAAAATGA
AAGTGAAAAATTAGAAAAAGAAGAAAACTTTAACAAATCGAAAAATATCG
AAATCCATGACAAAAGCAAAGAGATCAAATGTGATTCAAATGAGTCAGAA
ATCGACAAAGAAAAATATCCGGAGGACCCGGAAACATTAGAAATGATTAA
TGAAAGTGAAGAAAATCCTGCTTCAAGAATTAAATGGAGCTTCATTCTGC
CTTGTGACGTAAGTCATATAAAAGTAGTGGACCACGAAAATTCAATGATG
AAAACCGATTATAATTTATTTAAGGGAGAAGTCAAAATAGATTTGCTCGA
AGCAATGATTAATCCTGACATCCGAAAACTTGTTGATGAGGCTGTTCAAG
AAGAAGGATTGGATTTCGGAAGTTTATAAATTTATCTCTTATAAACACCG
AAGAACTGATTTGCTCCAAAAAAGAAACATTTCATTTTGTAAATATA
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protein sequence of SMED30002145-orf-1

>SMED30002145-orf-1 ID=SMED30002145-orf-1|Name=SMED30002145-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1241bp
MTTKENQQKNCNKIGREYFNVSSFTSETRDLLLKPENGNTNELLLLKKFP
NTINKEKNNLESILNDLKFSYEVAAERCSYLLPYDEKFYESVYNFPRTVK
KIKKRKCYSDKHFCHSMSNVTEYIPLPPVGKPELFLIKSQEKGLNNKIIC
QDPIEVVATEKELHQSRRHWDEYILSLMSQNTAQYLAYNLTKDENQADRL
QRLVNNWYGPPSSFRELIPDDSADKDPEEVRSDLKSIFPYKYYMDKIKSA
DKLPVEPVKPFQVQPTLKTRICNLVNKEDNLHSATDQNDPYGDDTKASFY
RLPVLVRKTKKTNKEVNIESVNPTTRSLKEFQLPKTPPKSVNSKLGNKVL
KTDNQYQKDLYFNEKKNQKKLLNKPDNIINFDGKIYVKNLQPIWPCQITS
TRFSTEDVDDSQLLETGITKGQNRWTQLPNKQEEDLMKADNALELENLER
QNSRKRARDHSSLNLLVDQWRKKWQLTQKYVDSTVDELLRDMADVHPTIR
LQAIVTAAKAATIIHNQKYGQTNTVQETVNSDCLPPILVNAIEILLEDPH
FQVRKAAAIALHSLEKSTDKSLNILKELLISDSNIDRWAAVQCLAVSSSA
DSFVIGELIDQLMNSEDILVHEKASYLLAKVSYHSKLVHGMLGEKLNAIS
WRQRLIICKTISLLHGPLNKDLMRKVIYLMWHDPHKQVKIAASQVLGKTG
NGKAVHEELITKLQSDSELIRADALEKIGILKVMTTRIMPAFLKCFHDEF
VLVRKEVCRACYYLKIQDTICVENLLQLARYDPLWKVKFYAIKALSKAQT
CISEIRSCILWALQFESKVQLRLVALQVIGTMPTLDTEIVDIIKSRCLVE
SDKSILRTLHKILNRVNINPVVDINTVAEIKEEVRKFFSNKDHIINVILT
NEAIEDYNFLKETLIGTSNQFKQFKQFNENSEELQTVSEFSDSESEDNST
NEDSEQLNRDLALSPRKSQIDEAIVETEEKHVNSKVNSTKDDIDIISDIV
KEDLTNSPVAMPNNNAFGEEILETQKFIDNETVINDSGGIIKETKRLSSV
SNDLINDPGSIDTNRGFDIENGEFSDELDMIETEDGSKEIKISTKEFEID
RGKPVESETIKNENESEKLEKEENFNKSKNIEIHDKSKEIKCDSNESEID
KEKYPEDPETLEMINESEENPASRIKWSFILPCDVSHIKVVDHENSMMKT
DYNLFKGEVKIDLLEAMINPDIRKLVDEAVQEEGLDFGSL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR011989ARM-like
IPR016024ARM-type_fold
Vocabulary: molecular function
TermDefinition
GO:0005488binding