TNF receptor-associated factor 3

Overview
NameTNF receptor-associated factor 3
Smed IDSMED30002070
Length (bp)2234
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TNF receptor-associated factor 3 (SMED30002070) t-SNE clustered cells

Violin plots show distribution of expression levels for TNF receptor-associated factor 3 (SMED30002070) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor-associated factor 3 (SMED30002070) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor-associated factor 3 (SMED30002070) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30002070

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30002070h1SMcG0019727 SmedASXL_004725SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30002070h1SMcG0019727 SmedASXL_004725SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30002070h1SMcG0019727 Contig42386newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002070h1SMcG0019727 Contig42386uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 73.9442 bits (180), Expect = 4.236e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  339 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 418
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 73.9442 bits (180), Expect = 5.045e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  397 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 476
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 73.9442 bits (180), Expect = 5.045e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  397 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 476
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 73.9442 bits (180), Expect = 5.749e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  422 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 501
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 73.9442 bits (180), Expect = 5.749e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  422 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 501
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Celegans
Match: trf-2 (TNF Receptor Associated Factor (TRAF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N586])

HSP 1 Score: 58.5362 bits (140), Expect = 6.011e-9
Identity = 41/129 (31.78%), Postives = 61/129 (47.29%), Query Frame = 3 
Query: 1626 SPPFYSSVNGYKM-CLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLM--DQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI 2003
            S PFYS   GYKM  +    G  L F  +  VF C+M+GE DD+L WP   +VT S++  D+   +   ++T      P   +F+ +RP  +      GT  F +F  L        +G I I+  V +
Sbjct:  185 SQPFYSHGYGYKMMAVAAPYGDGLAFREYFSVFVCLMKGEWDDILEWPFRCDVTFSILSDDKKELL---TKTIYVNEMPEIQEFL-ERPEGLRN----GTFGFQNFLPLAKVTEFAADGDIFIQIKVLL 305
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0334401)

HSP 1 Score: 68.5514 bits (166), Expect = 1.001e-11
Identity = 45/127 (35.43%), Postives = 66/127 (51.97%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFD-SHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFL 1943
            I ++  K A AR    ++ VSPPFY+S  GYK+   + L GN P + +H+ V+  V+ GE D +L WP    +T +L +Q A          F   P+ W+  F RPSN      FG P+F+  + L
Sbjct:  328 ITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPT-WE-NFQRPSNEPDQLGFGFPRFISHELL 452
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0077429)

HSP 1 Score: 68.1662 bits (165), Expect = 1.190e-11
Identity = 45/127 (35.43%), Postives = 66/127 (51.97%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFD-SHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFL 1943
            I ++  K A AR    ++ VSPPFY+S  GYK+   + L GN P + +H+ V+  V+ GE D +L WP    +T +L +Q A          F   P+ W+  F RPSN      FG P+F+  + L
Sbjct:  337 ITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPT-WEN-FQRPSNEPDQLGFGFPRFISHELL 461
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Zebrafish
Match: BX901915.1 (pep chromosome:GRCz11:CHR_ALT_CTG5_1_18:28764891:28768979:-1 gene:ENSDARG00000109857.1 transcript:ENSDART00000191629.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX901915.1)

HSP 1 Score: 74.3294 bits (181), Expect = 4.159e-14
Identity = 52/153 (33.99%), Postives = 76/153 (49.67%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +     R ++   TT+     ++RL       L  K R    ++ L   SI  M   MRE++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:   59 IVCVLNREMERSATTMEAYNRQHRLDQDKIEILNNKVRQLERTVGLRDLSIVEMEAKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 211
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Zebrafish
Match: AL844899.1 (pep chromosome:GRCz11:CHR_ALT_CTG5_2_4:28756846:28760787:-1 gene:ENSDARG00000111038.1 transcript:ENSDART00000183806.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:AL844899.1)

HSP 1 Score: 74.3294 bits (181), Expect = 4.159e-14
Identity = 52/153 (33.99%), Postives = 76/153 (49.67%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +     R ++   TT+     ++RL       L  K R    ++ L   SI  M   MRE++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:   59 IVCVLNREMERSATTMEAYNRQHRLDQDKIEILNNKVRQLERTVGLRDLSIVEMEAKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 211
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Zebrafish
Match: unm_sa808 (un-named sa808 [Source:ZFIN;Acc:ZDB-GENE-120727-21])

HSP 1 Score: 72.0182 bits (175), Expect = 2.613e-13
Identity = 50/153 (32.68%), Postives = 76/153 (49.67%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            V     R ++   TT+     ++RL      AL  K R     + +   ++  M   +RE++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:   65 VVCVLNREVERFATTMEASNRQHRLDQDKIEALSNKVRQLERQVGVKDLTVAEMEGRLREMSATTFDGVFIWRISDFTKKRQDAIAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGMSDALLKWPFNQKVTLMLLDQ 217
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Zebrafish
Match: traf2a (Tnf receptor-associated factor 2a [Source:ZFIN;Acc:ZDB-GENE-071120-2])

HSP 1 Score: 72.7886 bits (177), Expect = 6.803e-13
Identity = 52/153 (33.99%), Postives = 76/153 (49.67%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +     R ++   TT+     ++RL       L  K R    ++ L   SI  M   MRE++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:  359 IVCVLNREMERSATTMEAYNRQHRLDQDKIEILNNKVRQLERTVGLRDLSIVEMEAKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 511
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Zebrafish
Match: traf2b (Tnf receptor-associated factor 2b [Source:ZFIN;Acc:ZDB-GENE-030131-5345])

HSP 1 Score: 68.9366 bits (167), Expect = 1.262e-11
Identity = 38/98 (38.78%), Postives = 55/98 (56.12%), Query Frame = 3 
Query: 1512 RSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +S+  +++      F + I  F ++   A  G      SP FYSS  GYKMCLR+ L G+     SHL +FF VM+G+ D +L WP   +VT+ L+DQ
Sbjct:  371 QSLRELQFCTYDGVFIWKIAEFSRRRQDAVAGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGSHLSLFFVVMKGKYDALLKWPFSQKVTLMLLDQ 468
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 72.4034 bits (176), Expect = 1.174e-12
Identity = 37/84 (44.05%), Postives = 52/84 (61.90%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            F + I+ F +K   A  G      SPPFY++  GYKMCLR+ L G+    ++HL +FF VM+G ND +L WP   +VT+ L+DQ
Sbjct:  334 FIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ 417
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 72.4034 bits (176), Expect = 1.348e-12
Identity = 34/80 (42.50%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +V++ LMDQ
Sbjct:  390 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQ 469
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 72.0182 bits (175), Expect = 1.380e-12
Identity = 37/84 (44.05%), Postives = 52/84 (61.90%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            F + I+ F +K   A  G      SPPFY++  GYKMCLR+ L G+    ++HL +FF VM+G ND +L WP   +VT+ L+DQ
Sbjct:  307 FIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ 390
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 72.4034 bits (176), Expect = 1.522e-12
Identity = 34/80 (42.50%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +V++ LMDQ
Sbjct:  415 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQ 494
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Xenopus
Match: egf (epidermal growth factor [Source:Xenbase;Acc:XB-GENE-951823])

HSP 1 Score: 72.0182 bits (175), Expect = 2.015e-12
Identity = 58/217 (26.73%), Postives = 94/217 (43.32%), Query Frame = 3 
Query: 1392 TSSTRPIKAVTTTLPGRVARN------RLALPRKQRGFAASIPLLSRSID----PMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLP----FDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVA 2000
            T  TR ++     L GR+ R        +A    Q  +   +    RS+D     M   +    F + INNF+       +  P+   S  FY+   GYK+CLR+ L   LP      +++ +F   M+GE D +LPWP+   + +S++DQ   V    +     + P      F RP+     + FG   F+H   L      + N ++++RCSV 
Sbjct:  325 TQETRNLRETIEQLEGRLVRQDHQIRELIAKMETQCTYVNELKHTIRSLDNRLGEMESQQCSGIFIWRINNFNSLLKNQEEERPVVIHSQGFYTGKPGYKLCLRLHL--QLPSAQRCANYISLFVHTMQGEYDSLLPWPLQGTIRLSILDQSEGVAMQDQEEVMDTKPE--LLAFQRPTVARNPKGFGYVTFMHLQAL-KQRQYVKNDTLLVRCSVT 536
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 74.3294 bits (181), Expect = 2.878e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  396 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 475
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 74.3294 bits (181), Expect = 2.878e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  396 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 475
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 73.9442 bits (180), Expect = 3.226e-13
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  421 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 500
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Mouse
Match: Traf5 (TNF receptor-associated factor 5 [Source:MGI Symbol;Acc:MGI:107548])

HSP 1 Score: 67.3958 bits (163), Expect = 5.873e-12
Identity = 45/132 (34.09%), Postives = 66/132 (50.00%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFD-SHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWF--GTPQFVHFDFLFNN 1952
            + ++  K   A +G  +   S PFY+S  GY++C R  L G+     +HL ++F VMRGE D +L WP    VT+ L+DQ     +   T  F++ P+     F RP   DG      G P+FV    L N+
Sbjct:  102 VTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVET--FKADPNSSS--FKRP---DGEMNIASGCPRFVSHSTLENS 226
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Mouse
Match: Traf5 (TNF receptor-associated factor 5 [Source:MGI Symbol;Acc:MGI:107548])

HSP 1 Score: 67.3958 bits (163), Expect = 5.873e-12
Identity = 45/132 (34.09%), Postives = 66/132 (50.00%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFD-SHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWF--GTPQFVHFDFLFNN 1952
            + ++  K   A +G  +   S PFY+S  GY++C R  L G+     +HL ++F VMRGE D +L WP    VT+ L+DQ     +   T  F++ P+     F RP   DG      G P+FV    L N+
Sbjct:  102 VTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVET--FKADPNSSS--FKRP---DGEMNIASGCPRFVSHSTLENS 226
[Close]
BLAST of TNF receptor-associated factor 3 vs. UniProt/SwissProt
Match: sp|Q60803|TRAF3_MOUSE (TNF receptor-associated factor 3 OS=Mus musculus OX=10090 GN=Traf3 PE=1 SV=2)

HSP 1 Score: 73.9442 bits (180), Expect = 2.256e-12
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  421 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 500
[Close]
BLAST of TNF receptor-associated factor 3 vs. UniProt/SwissProt
Match: sp|Q13114|TRAF3_HUMAN (TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2)

HSP 1 Score: 73.9442 bits (180), Expect = 2.761e-12
Identity = 35/80 (43.75%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF +MRGE D +LPWP   +VT+ LMDQ
Sbjct:  422 IRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQ 501
[Close]
BLAST of TNF receptor-associated factor 3 vs. UniProt/SwissProt
Match: sp|Q28DL4|TRAF6_XENTR (TNF receptor-associated factor 6 OS=Xenopus tropicalis OX=8364 GN=traf6 PE=2 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 1.706e-11
Identity = 58/217 (26.73%), Postives = 94/217 (43.32%), Query Frame = 3 
Query: 1389 TTSSTRPIKAVTTTLPGRVARN------RLALPRKQRGFAASIPLLSRSID----PMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLP----FDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSV 1997
             T  TR ++     L GR+ R        +A    Q  +   +    RS+D     M   +    F + INNF+       +  P+   S  FY+   GYK+CLR+ L   LP      +++ +F   M+GE D +LPWP+   + +S++DQ   V    +     + P      F RP+     + FG   F+H   L      + N ++++RCSV
Sbjct:  324 CTQETRNLRETIEQLEGRLVRQDHQIRELIAKMETQCTYVNELKHTIRSLDNRLGEMESQQCSGIFIWRINNFNSLLKNQEEERPVVIHSQGFYTGKPGYKLCLRLHL--QLPSAQRCANYISLFVHTMQGEYDSLLPWPLQGTIRLSILDQSEGVAMQDQEEVMDTKPE--LLAFQRPTVARNPKGFGYVTFMHLQAL-KQRQYVKNDTLLVRCSV 535
[Close]
BLAST of TNF receptor-associated factor 3 vs. UniProt/SwissProt
Match: sp|P39428|TRAF1_MOUSE (TNF receptor-associated factor 1 OS=Mus musculus OX=10090 GN=Traf1 PE=1 SV=2)

HSP 1 Score: 69.3218 bits (168), Expect = 4.853e-11
Identity = 39/113 (34.51%), Postives = 61/113 (53.98%), Query Frame = 3 
Query: 1476 QRGFAASIPLLSRSIDPMRWMREIA---PFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFD-SHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            Q+  A    +L +    +R M E +    F + I N  ++   +  G  +   SP FY++  GYK+CLR+ L G+     +HL +F  +MRGE D +LPWP  ++VT  L+DQ
Sbjct:  233 QQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ 345
[Close]
BLAST of TNF receptor-associated factor 3 vs. UniProt/SwissProt
Match: sp|Q13077|TRAF1_HUMAN (TNF receptor-associated factor 1 OS=Homo sapiens OX=9606 GN=TRAF1 PE=1 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 7.204e-11
Identity = 36/96 (37.50%), Postives = 55/96 (57.29%), Query Frame = 3 
Query: 1527 MRWMREIA---PFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFD-SHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +R M E +    F + I N  ++   +  G  +   SP FY++  GYK+CLR+ L G+     +HL +F  +MRGE D +LPWP  ++VT  L+DQ
Sbjct:  257 LRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ 352
[Close]
BLAST of TNF receptor-associated factor 3 vs. TrEMBL
Match: A0A0F7GY08 (TNF receptor associated factor 5 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 100.908 bits (250), Expect = 1.032e-20
Identity = 58/140 (41.43%), Postives = 81/140 (57.86%), Query Frame = 3 
Query: 1545 IAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFDS-HLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSN---IDGHRWFGTPQFVHFDFLFNN 1952
            IAPFE+ I NF +KH RA  G  +   S PFYS  NGYK+ LR+D  G+    + +L V F ++ GE DD L WPM  +V ISL++Q   + + S+ + F S   + K IF +P +    D   +FGT +  +F  LFNN
Sbjct:   45 IAPFEWKITNFMEKHERAISGEKLTVYSEPFYSHKNGYKIQLRIDPNGDEAVKALYLSVSFGIIGGEYDDELDWPMTKQVKISLINQKTGLVHISKRYKFDSVLKKSKCIFFKPISRFEDDEDYFFGTLKLSNFSVLFNN 184
[Close]
BLAST of TNF receptor-associated factor 3 vs. TrEMBL
Match: I1ZID8 (TNF receptor associated factor-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 1.345e-15
Identity = 44/111 (39.64%), Postives = 67/111 (60.36%), Query Frame = 3 
Query:  141 KMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHI 473
            K+  LL  Y FEV+     ++ C +CK+LL NA QS CGC FC  CI  Y+S  + +CPG ++ CKE  + I  N+  D+  N+K+A + V+CP + C+   EL  ++ H+
Sbjct:    5 KINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHL 115
[Close]
BLAST of TNF receptor-associated factor 3 vs. TrEMBL
Match: A0A1X7UQU4 (Uncharacterized protein OS=Amphimedon queenslandica OX=400682 GN=105312983 PE=4 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 6.718e-14
Identity = 125/565 (22.12%), Postives = 223/565 (39.47%), Query Frame = 3 
Query:  252 CGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIER-NLQVDHAANKKVANVTVRCPI--DNCEFRTELKAMDSHIDSHNDVV------DSQGKFLRE-------------PLE-KLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILID--MARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLNVRRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTV--LKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTXXXXXXXXXXXXIVTTSSTRPIKAV--TTTLPGRVARNRLALPRKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNF--HQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPF-DSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSA 1850
            CG +FC  CI+       K CP         +  +++  + +D    +K+ ++ V C      C++  EL+ +++H+D     V      D   K+ R+             P E  L K++  L++  +  RK    K+ +I +++E++D  RK  + +   +   ++  M + T+++ +  + G  +           +KTAM +   +W+                  + A + +  G       A++  G     ++   ++EL            +K+AA  + ++   N   Q+    E +  T +A  +          E  ++     +   + ETT Q    +  LK    +KL  EL Q+  +  K  +E   K                ++ + V     R  K    T+     + R   A+ +   GF   IP   R + P+     I P +F + NF  H+K  +A         SPPFYS   GYK CLR+D  G L   +SHL V+  VMRG  D+ L WP   +VT+ L++  A   +      F  A
Sbjct:   50 CGAKFCQSCIERE-HFAGKPCP---------LCRVKKFKMLIDQDHKRKILSLKVYCTQREGGCQWIGELRHIENHLDKDCQYVLEACCWDCGRKYARKDVGFHEQDECVNRPRELVLLKKVEALEKQCEAQRKSLEEKDRIIKELKEKMDEDRKEMETKMANVSQQLETKMDKITKELEAKMADGTRE-----------LKTAMADTAKEWE-----------------AKTANITKELGEKVETKMANNAEGLEA--KLANNMKEL-----------EKKFAANAEKIEENDNKAIQNNREMEEKFRTEIAAVKEEGKGLQKVVEEVEKKLIKANEETNRETTRQLNVRIEELKQEVEKKLKAELKQLENNKIKPLEEKMTKMDKEVTAAVKTAGDSNVQVQTVQDRMKRNDKTQKETSDRISIIDRQFEAMRKMSSGF--KIPEWQRPL-PLTSFSNIPPCQFTMMNFTYHKKQGKA-------WYSPPFYSEPGGYKFCLRIDPNGMLEGKESHLSVWVYVMRGRFDESLKWPFTGKVTVQLLNWKADKGHIQNIVSFDDA 553
[Close]
BLAST of TNF receptor-associated factor 3 vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 1.156e-13
Identity = 39/120 (32.50%), Postives = 69/120 (57.50%), Query Frame = 3 
Query:  120 MASLKYSKMWTLLNEYKFE-VDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHID 476
            M   K   +  LL++Y  + VD   N D++C +C  L+++A +S CGC +C+ CI+ YLS    +CPG    CKE  +N+E ++  +   + +++ + V+CP   C + +EL  +  H+D
Sbjct:    1 MIPSKLDNVQELLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYLNLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLD 120

HSP 2 Score: 68.5514 bits (166), Expect = 2.619e-8
Identity = 40/139 (28.78%), Postives = 72/139 (51.80%), Query Frame = 3 
Query: 1581 QKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSV 1997
            +++++ R+ +  D  S  F S  + YK CL + + G+     +LG++  +M+GE DD L WPM   VT+S+++Q +   + +  F + +     K  FDRP +       GT   V + ++     +L N SI++ C V
Sbjct:  323 EEYSKKRRTVT-DVYSDSFQS--HNYKFCLNLYIYGD-----NLGLWCVIMKGEKDDFLEWPMRRTVTLSIIEQDSLKTHKTTVFQYDTYQRNKK-AFDRPKDERNDYCIGTDSLVRYSYIKETPMILVNDSIIVACVV 452
[Close]
BLAST of TNF receptor-associated factor 3 vs. TrEMBL
Match: F7BIZ0 (TNF receptor-associated factor 3-like OS=Ciona intestinalis OX=7719 GN=LOC100184576 PE=4 SV=2)

HSP 1 Score: 82.0333 bits (201), Expect = 3.141e-13
Identity = 53/145 (36.55%), Postives = 78/145 (53.79%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSV 1997
            INNF ++   A  G  +   S PFY+S  GYKMC RV L G+ +   +H+ +FF +M+GE D++LPWP   +VT+ L+DQ     + S    FR  P+   F   +P++ D +   G P FV  + L    S + +  I IR  V
Sbjct:  144 INNFQRRKREAESGRALSIYSQPFYTSRYGYKMCARVYLNGDGMGKGTHVSLFFVLMKGEYDNLLPWPFRQKVTLMLLDQGLERRHLSDM--FRPDPTSSSFT--KPTS-DMNIASGCPLFVAHN-LIEGSSYVKDDVIFIRIHV 282
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Cavefish
Match: ENSAMXT00000035169.1 (pep primary_assembly:Astyanax_mexicanus-2.0:9:3354744:3362219:1 gene:ENSAMXG00000029095.1 transcript:ENSAMXT00000035169.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 73.9442 bits (180), Expect = 6.063e-15
Identity = 36/80 (45.00%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++ A A     +   S PFY+   GYKMC RV L G+ +   +HL +FF VMRGE D +LPWP   +VT+ LMDQ
Sbjct:   10 IRDYKRRKAEAVASKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQ 89
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Cavefish
Match: traf2a (TNF receptor-associated factor 2-like [Source:NCBI gene;Acc:103036375])

HSP 1 Score: 72.4034 bits (176), Expect = 5.677e-13
Identity = 52/153 (33.99%), Postives = 76/153 (49.67%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +     R ++   TT+     ++RL       L  K R    ++ L   SI  M   MRE++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:  243 IVCVLNREMERSATTMEAYNRQHRLDQDKIEILNNKVRQLERTVGLRDLSIVEMEGKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 395
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Cavefish
Match: traf2a (TNF receptor-associated factor 2-like [Source:NCBI gene;Acc:103036375])

HSP 1 Score: 72.7886 bits (177), Expect = 5.936e-13
Identity = 52/153 (33.99%), Postives = 76/153 (49.67%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            +     R ++   TT+     ++RL       L  K R    ++ L   SI  M   MRE++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:  356 IVCVLNREMERSATTMEAYNRQHRLDQDKIEILNNKVRQLERTVGLRDLSIVEMEGKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 508
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Cavefish
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:103028261])

HSP 1 Score: 71.633 bits (174), Expect = 1.268e-12
Identity = 38/84 (45.24%), Postives = 51/84 (60.71%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            F + I++F ++   A  G      SP FYSS  GYKMCLR+ L G+     SHL +FF VMRG+ D +L WP   +VT+ L+DQ
Sbjct:  384 FVWKISDFSRRRQDALAGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGSHLSLFFVVMRGKYDALLKWPFSQKVTLMLLDQ 467
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Cavefish
Match: traf5 (TNF receptor-associated factor 5 [Source:NCBI gene;Acc:103031120])

HSP 1 Score: 68.1662 bits (165), Expect = 1.863e-11
Identity = 43/128 (33.59%), Postives = 68/128 (53.12%), Query Frame = 3 
Query: 1563 IINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFV-HFDF 1940
            +I   H  H +   G  ++S  PPFY+S +GYK+  RV LGG      +HL ++  +MRG+ D +LPWP    VT++++DQ     + S +F     P      F RP++ + +   G P+F+ H D 
Sbjct:  402 LIWKVHDYHRKKEAGTALNS--PPFYTSHSGYKLSARVYLGGEGTARGTHLSLYVMLMRGDFDSLLPWPFRQNVTLAVLDQSGNRNHVSLSF----TPDLASNNFRRPTS-ETNAALGFPRFITHADL 522
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002130.1 (pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 gene:ENSPMAG00000001936.1 transcript:ENSPMAT00000002130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.485 bits (184), Expect = 1.165e-14
Identity = 53/145 (36.55%), Postives = 73/145 (50.34%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSV 1997
            I ++ ++   A  G  +   S PFY+S  GYKMC R  L G+ +   +HL +FF VMRGE D +L WP    VT+SL+DQ A   + S TF     P      F RP   D +   G P FV    L  + S L + ++ +R  V
Sbjct:  274 IRDYARRKQEAASGRTLSLYSQPFYTSPFGYKMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLEWPFRRRVTLSLLDQGAARRHLSDTF----TPDPASGSFRRPDG-DMNVASGCPLFVSHVALEGS-SYLVDDTVFVRVVV 412
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000074.1 (pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-1 gene:ENSPMAG00000000066.1 transcript:ENSPMAT00000000074.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.485 bits (184), Expect = 1.531e-14
Identity = 56/152 (36.84%), Postives = 78/152 (51.32%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI*LAGD 2018
            I ++ ++   A  G  +   S PFY+S  GY+MC R  L G+ +   +HL +FF VMRGE D +LPWP    VT++L+DQ A     S TF    A S     F RP++ D +   G P FV    L  + S L + +I I+  V     GD
Sbjct:  331 IRDYARRKQDAVSGRTLSLYSQPFYTSPFGYRMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLPWPFRQRVTLTLLDQGAARRQLSDTFKPDPASSS----FRRPTS-DMNIASGCPLFVSHVAL-ESASYLQDDTIFIKVVVDTGELGD 476
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Sea Lamprey
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 54.6842 bits (130), Expect = 5.939e-8
Identity = 38/135 (28.15%), Postives = 63/135 (46.67%), Query Frame = 3 
Query: 1635 FYSSVNGYKMCLRVDL--GGNLPFDS------------HLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSV 1997
            FY+ V GY++CLR+ +  G  +P  +            HL +F  +++G+ D  LPWP    + IS++DQ      +    +   A  Q    F RPS     + FG   F+  + L +  S L +  +++RC V
Sbjct:  432 FYTGVPGYRLCLRLQVLSGREVPAGAASPSVLLAGRQPHLALFVHLLQGDYDHRLPWPFKGRIRISVVDQCER--DSVHVTEMMDADPQLS-AFQRPSVHRNPKGFGYMNFMDINTLHHR-SYLRDDCLVVRCEV 562
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Nematostella
Match: EDO48773 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI91])

HSP 1 Score: 78.1814 bits (191), Expect = 3.489e-15
Identity = 49/156 (31.41%), Postives = 79/156 (50.64%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGG-NLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQW------KFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVA 2000
            F + ++NF Q    +  GL     SPPFY+S+ GYKMCLR++L G +     H+ +F  +M+G+ D +L WP    +T+S++DQ       S   D R   S+          F RP++   H+ +G  +F   D L      + N SI++R  ++
Sbjct:  334 FIWKLDNFRQCREGSIAGLTAAIHSPPFYTSMYGYKMCLRMNLNGVDGGLGEHVSLFIHMMQGDWDGILEWPFIGRITLSILDQ-------SDQIDSRRPISETLVAKPNLLAFQRPTSPRNHKGYGYVEFCPIDQLTEG-QYIKNNSILVRIQIS 481
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Nematostella
Match: EDO35237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM27])

HSP 1 Score: 69.707 bits (169), Expect = 1.966e-12
Identity = 46/127 (36.22%), Postives = 68/127 (53.54%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPF-DSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPS-NIDGHRWFGTPQFV 1928
            F + I+ F +++A A+ G      S PFY+   GYK+C R+   G+    D++L +F  +MRGE D +LPWP    +TI+L+DQ   +   S TFD    P      F RP+ NI+     G P+F 
Sbjct:  382 FLWKIDKFTERYAEAKSGNATSIYSSPFYTHRFGYKLCARLFPNGDGSARDNYLSIFIALMRGEYDSILPWPFQETITITLIDQDNGMN-ISETFD----PDPCSISFQRPTRNINVAS--GCPRFC 501
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Nematostella
Match: EDO38873 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBN4])

HSP 1 Score: 64.6994 bits (156), Expect = 6.453e-11
Identity = 32/80 (40.00%), Postives = 47/80 (58.75%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I N   K + A  G      SP F++  +GYKMC R+ L G+ +  + H+ +FF +MRGE D +L WP   +VT+ L+DQ
Sbjct:  339 ITNVANKRSEATSGRVTSFYSPCFFTGPHGYKMCARIYLNGDGMGRNHHVSLFFVIMRGEFDALLRWPFRQKVTLMLLDQ 418
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Nematostella
Match: EDO49464 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG36])

HSP 1 Score: 63.5438 bits (153), Expect = 1.743e-10
Identity = 33/80 (41.25%), Postives = 45/80 (56.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I+ + +++     G      SPPFY    GYK C RV   G+ +   SHL +FF +MRGE D +LPWP   +VT  L+DQ
Sbjct:  384 IDEYTRRYQEGVSGKTPSIYSPPFYVGRYGYKACARVYPNGDGMGKGSHLSLFFVLMRGEFDALLPWPFRQKVTFKLLDQ 463
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Nematostella
Match: EDO25839 (pep supercontig:ASM20922v1:NEMVEscaffold_10031:118:2414:-1 gene:NEMVEDRAFT_v1g156301 transcript:EDO25839 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.9214 bits (141), Expect = 1.161e-9
Identity = 54/154 (35.06%), Postives = 71/154 (46.10%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSV-SPPFYSSVNGYKMCLRVDLGGNLPFDSH-LGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVP------YTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI 2003
            ++NF++K AR R G   D V S PFY+S  GYK+     L G    +   + V+ CVM GE D VL WP+    T +LMDQ   V          +  DF+    + K I DRP   +     G   FV  D L    + L + S  IR  V I
Sbjct:   82 VSNFNKKVARIRTGRGDDPVCSEPFYTSAFGYKISCWAYLNGRGREEGRSVSVYACVMYGEYDAVLKWPIRPRYTFALMDQNPDVEDRREIVRVRKVNDFKRDDVRRKGI-DRPKRDERAIIVGFDDFVGHDEL-ETGTYLADDSFFIRVLVDI 233
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Medaka
Match: unm_sa808 (TNF receptor-associated factor 2 [Source:NCBI gene;Acc:101155367])

HSP 1 Score: 74.7146 bits (182), Expect = 1.910e-13
Identity = 52/153 (33.99%), Postives = 78/153 (50.98%), Query Frame = 3 
Query: 1386 VTTSSTRPIKAVTTTLPGRVARNRL------ALPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            V     R ++  TTT+     +++L      AL  K R    ++ L   ++  M   +RE+A       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:  380 VVCVLNREVERFTTTMEASNRQHKLDQDKIEALSNKVRQLERTVGLKDLTVAEMEGRLREMAATTFDGVFIWRISDFAKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGLSDALLKWPFNQKVTLMLLDQ 532
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Medaka
Match: traf3 (TNF receptor associated factor 3 [Source:NCBI gene;Acc:101161601])

HSP 1 Score: 72.7886 bits (177), Expect = 5.261e-13
Identity = 36/80 (45.00%), Postives = 49/80 (61.25%), Query Frame = 3 
Query: 1566 INNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            I ++ ++   A  G  +   S PFY+   GYKMC RV L G+ +   +HL +FF VMRGE D +LPWP   +VT+ LMDQ
Sbjct:  304 IRDYKRRKQDAVAGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQ 383
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Medaka
Match: ENSORLT00000020861.2 (TNF receptor-associated factor 2 [Source:NCBI gene;Acc:101167626])

HSP 1 Score: 70.8626 bits (172), Expect = 2.454e-12
Identity = 45/121 (37.19%), Postives = 65/121 (53.72%), Query Frame = 3 
Query: 1464 LPRKQRGFAASIPLLSRSIDPMRW-MREIAP------FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            L  K R    ++ L   SI  M   M++++       F + I++F +K   A  G      SP FY+S  GYKMCLR+ L G+     +HL +FF VMRG +D +L WP   +VT+ L+DQ
Sbjct:  385 LSNKVRQLERTVSLRDLSIVEMEGKMKDMSAATYDGIFIWKISDFTKKRQDAMAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 505
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 68.1662 bits (165), Expect = 1.747e-11
Identity = 36/84 (42.86%), Postives = 48/84 (57.14%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            F + I +F  +   A  G      SP FYSS  GYKMCLR+ L G+     +HL +FF VMR + D +L WP   +VT+ L+DQ
Sbjct:  369 FVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ 452
[Close]
BLAST of TNF receptor-associated factor 3 vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 67.781 bits (164), Expect = 1.951e-11
Identity = 36/84 (42.86%), Postives = 48/84 (57.14%), Query Frame = 3 
Query: 1554 FEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQ 1802
            F + I +F  +   A  G      SP FYSS  GYKMCLR+ L G+     +HL +FF VMR + D +L WP   +VT+ L+DQ
Sbjct:  376 FVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ 459
[Close]
BLAST of TNF receptor-associated factor 3 vs. Planmine SMEST
Match: SMESG000014397.1 (SMESG000014397.1)

HSP 1 Score: 1271.53 bits (3289), Expect = 0.000e+0
Identity = 623/628 (99.20%), Postives = 625/628 (99.52%), Query Frame = 3 
Query:  120 MASLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLNVRRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTXXXXXXXXXXXXIVTTSSTRPIKAVTTTLPGRVARNRLALPRKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI 2003
            MASLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLN RRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTPAPKPGKPLKAKIVTTS+TRPIKAVTTTLPGRVARNRLAL RKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPID VSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAP+QWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI
Sbjct:    1 MASLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLNGRRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTPAPKPGKPLKAKIVTTSATRPIKAVTTTLPGRVARNRLALSRKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDCVSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPNQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI 628
[Close]
BLAST of TNF receptor-associated factor 3 vs. Planmine SMEST
Match: SMESG000014397.1 (SMESG000014397.1)

HSP 1 Score: 1253.04 bits (3241), Expect = 0.000e+0
Identity = 615/620 (99.19%), Postives = 617/620 (99.52%), Query Frame = 3 
Query:  144 MWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLNVRRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTXXXXXXXXXXXXIVTTSSTRPIKAVTTTLPGRVARNRLALPRKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI 2003
            MWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLN RRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTPAPKPGKPLKAKIVTTS+TRPIKAVTTTLPGRVARNRLAL RKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPID VSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAP+QWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI
Sbjct:    1 MWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSSAGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLNGRRDGQLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQKWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQEGSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPAKTPTVSKVTPAPKPGKPLKAKIVTTSATRPIKAVTTTLPGRVARNRLALSRKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDCVSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPNQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVAI 620
[Close]
BLAST of TNF receptor-associated factor 3 vs. Planmine SMEST
Match: SMESG000067208.1 (SMESG000067208.1)

HSP 1 Score: 132.109 bits (331), Expect = 1.218e-32
Identity = 58/119 (48.74%), Postives = 80/119 (67.23%), Query Frame = 3 
Query:  126 SLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSH 482
            S K+  +W LL +Y FEV     RD+IC ICK LL NA QS CGC +C+ CI+ YL  + K CPG+  GC E ++++  ++QVDH AN K++  TV+CP   C+F+ EL+ M+SHI SH
Sbjct:    2 SSKHDNLWDLLVKYNFEVTGKNYRDLICVICKRLLINAHQSCCGCRYCYKCIEKYLEDKKKLCPGKGEGCNEQLISL-FDIQVDHVANVKISKATVKCPDTICQFKDELRKMESHIKSH 119

HSP 2 Score: 78.5666 bits (192), Expect = 4.963e-15
Identity = 58/180 (32.22%), Postives = 88/180 (48.89%), Query Frame = 3 
Query: 1506 LSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRV-DLGGNLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFG------TPQFVHFDFLFNNLSLLYNGSIMIRCSVAI*LAGDNP 2024
            L+  I+ +++    +PF + I NF  K   A+       +S  FYS VNGYK+CL +   G N+  +  L V F +M+ E+D  L WPM   +TI L++Q     + S T++  S     +  F RP        FG        +FV F  + +N +L  N SI+I+C V    A +NP
Sbjct:  274 LTNVINGVKY----SPFIWKIENFSDKKNTAKNVCDSFILSDTFYSHVNGYKICLTIFPDGSNVSQNDWLSVGFHLMKSEHDKDLFWPMAMNITIGLVNQKTNQIHASETYNVNSVTDINRDRFFRPV-------FGMNGAVVAHKFVKFTAITSNANLCKNDSIVIKCVVKNIEATNNP 442
[Close]
BLAST of TNF receptor-associated factor 3 vs. Planmine SMEST
Match: SMESG000070126.1 (SMESG000070126.1)

HSP 1 Score: 131.724 bits (330), Expect = 2.167e-32
Identity = 65/220 (29.55%), Postives = 116/220 (52.73%), Query Frame = 3 
Query:  114 LIMASLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSH-------------------------NDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMAR 698
            +IMA+ KY ++W LL+EY+F  D+  + + +C IC S+LKN  QS CGC FC +CI +YL+ +   CPG S  CK+ ++N   +L  D+  ++K++ V V+CP   C++R+EL+ + +HI SH                         +D +   GK + E    LK E+  L   L   +++  NK+ +++ +   ++  +   + +  E+   +D  +
Sbjct:   25 VIMANAKYERIWKLLDEYEFAYDSLLSDEFLCVICNSILKNPYQSPCGCRFCMECIVDYLNDKETHCPGSSEDCKDQLINFNGDLHADYVISRKISQVKVKCPKALCDYRSELQNIGNHISSHKESCPYTNIGCQYPSAHMGLIVEHLHDQIYEHGKLVTESFANLKNEVASLTLALKHSKQELENKDNLLIDLENRLNELQGTREIKIQELTETLDKCK 244

HSP 2 Score: 100.908 bits (250), Expect = 3.477e-22
Identity = 59/169 (34.91%), Postives = 91/169 (53.85%), Query Frame = 3 
Query: 1497 IPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGGN-LPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVA 2000
            IP+   S D + +    APFE+ I +F  K  +A   +P   +S PFYS VNGYK+C+ +   G  +   S++ VF  VM+GE D  L WPM  ++ I L+DQ++   +  + FD+ SA  + K  + RP  +      G  QF+  + LFNN  +    SI+++C V 
Sbjct:  295 IPMKPISTDHISY----APFEWKIRDF--KALKASTVIPTYVISRPFYSHVNGYKLCMTIHPSGTGIGLGSYISVFIHVMKGEFDSNLAWPMKLDLRICLVDQISDSYFVDKKFDYSSAILRNKHKYSRPFCVKN-IGIGESQFIQLNALFNNSRIYLEDSIILKCFVG 456
[Close]
BLAST of TNF receptor-associated factor 3 vs. Planmine SMEST
Match: SMESG000070130.1 (SMESG000070130.1)

HSP 1 Score: 130.568 bits (327), Expect = 2.237e-32
Identity = 64/218 (29.36%), Postives = 114/218 (52.29%), Query Frame = 3 
Query:  120 MASLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFCFDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRCPIDNCEFRTELKAMDSHIDSH-------------------------NDVVDSQGKFLREPLEKLKKEMNGLKEGLDQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMAR 698
            MA+ KY ++W LL+EY+F  D+  + + +C IC S+LKN  QS CGC FC +CI +YL+ +   CPG S  CK+ ++N   +L  D+  ++K++ V V+CP   C++R+EL+ + +HI SH                         +D +   GK + E    LK E+  L   L   +++  NK+ +++ +   ++  +   + +  E+   +D  +
Sbjct:    1 MANAKYERIWKLLDEYEFAYDSLLSDEFLCVICNSILKNPYQSPCGCRFCMECIVDYLNDKETHCPGSSEDCKDQLINFNGDLHADYVISRKISQVKVKCPKTLCDYRSELQNIGNHISSHKESCPYTNIGCQYPSAHMGLIVEHLHDQIYEHGKLVTESFANLKNEVASLTLALKHSKQELENKDNLLIDLENRLNELQGTREIKIQELTETLDKCK 218

HSP 2 Score: 77.7962 bits (190), Expect = 6.107e-15
Identity = 59/204 (28.92%), Postives = 91/204 (44.61%), Query Frame = 3 
Query: 1392 TSSTRPIKAVTTTLPGRVARNRLALPRKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPIDSVSPPFYSSVNGYKMCLRVDLGG-NLPFDSHLGVFFCVMRGENDDVLPWPMCSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTPQFVHFDFLFNNLSLLYNGSIMIRCSVA 2000
            +S  R +K+V+           L    + R +         + DP      IAPF++ I NF    +  ++  P+   S PFYS  NGYK+CL V   G      +H+ VFF +M G  DD L WPM   V I L+DQ+                 Q+K  +++PS +      G  Q++  + L+ N  +  N SI+++C V 
Sbjct:  225 SSELRTLKSVSEVFSFNQENYYLQNKEEDRKYILQPNYNVSTFDP------IAPFKWQIYNFKVLQSEGKRK-PL--TSSPFYSHRNGYKLCLSVYPNGIGNGSGTHMAVFFHIMSGIFDDSLDWPMVLNVRICLVDQL--------------YEDQYK--YEKPSTVKN-MGIGESQYILLETLYRNSRIYSNDSIILKCYVG 402
The following BLAST results are available for this feature:
BLAST of TNF receptor-associated factor 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRAF34.236e-1343.75TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF35.045e-1343.75TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF35.045e-1343.75TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF35.749e-1343.75TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF35.749e-1343.75TNF receptor associated factor 3 [Source:HGNC Symb... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
trf-26.011e-931.78TNF Receptor Associated Factor (TRAF) homolog [So... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Traf41.001e-1135.43gene:FBgn0026319 transcript:FBtr0334401[more]
Traf41.190e-1135.43gene:FBgn0026319 transcript:FBtr0077429[more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BX901915.14.159e-1433.99pep chromosome:GRCz11:CHR_ALT_CTG5_1_18:28764891:2... [more]
AL844899.14.159e-1433.99pep chromosome:GRCz11:CHR_ALT_CTG5_2_4:28756846:28... [more]
unm_sa8082.613e-1332.68un-named sa808 [Source:ZFIN;Acc:ZDB-GENE-120727-21... [more]
traf2a6.803e-1333.99Tnf receptor-associated factor 2a [Source:ZFIN;Acc... [more]
traf2b1.262e-1138.78Tnf receptor-associated factor 2b [Source:ZFIN;Acc... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRAF21.174e-1244.05TNF receptor associated factor 2 [Source:NCBI gene... [more]
ssh21.348e-1242.50slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
TRAF21.380e-1244.05TNF receptor associated factor 2 [Source:NCBI gene... [more]
ssh21.522e-1242.50slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
egf2.015e-1226.73epidermal growth factor [Source:Xenbase;Acc:XB-GEN... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Traf32.878e-1343.75TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf32.878e-1343.75TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf33.226e-1343.75TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf55.873e-1234.09TNF receptor-associated factor 5 [Source:MGI Symbo... [more]
Traf55.873e-1234.09TNF receptor-associated factor 5 [Source:MGI Symbo... [more]
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BLAST of TNF receptor-associated factor 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q60803|TRAF3_MOUSE2.256e-1243.75TNF receptor-associated factor 3 OS=Mus musculus O... [more]
sp|Q13114|TRAF3_HUMAN2.761e-1243.75TNF receptor-associated factor 3 OS=Homo sapiens O... [more]
sp|Q28DL4|TRAF6_XENTR1.706e-1126.73TNF receptor-associated factor 6 OS=Xenopus tropic... [more]
sp|P39428|TRAF1_MOUSE4.853e-1134.51TNF receptor-associated factor 1 OS=Mus musculus O... [more]
sp|Q13077|TRAF1_HUMAN7.204e-1137.50TNF receptor-associated factor 1 OS=Homo sapiens O... [more]
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BLAST of TNF receptor-associated factor 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0F7GY081.032e-2041.43TNF receptor associated factor 5 (Fragment) OS=Sch... [more]
I1ZID81.345e-1539.64TNF receptor associated factor-2 (Fragment) OS=Sch... [more]
A0A1X7UQU46.718e-1422.12Uncharacterized protein OS=Amphimedon queenslandic... [more]
T1E1011.156e-1332.50TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
F7BIZ03.141e-1336.55TNF receptor-associated factor 3-like OS=Ciona int... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000035169.16.063e-1545.00pep primary_assembly:Astyanax_mexicanus-2.0:9:3354... [more]
traf2a5.677e-1333.99TNF receptor-associated factor 2-like [Source:NCBI... [more]
traf2a5.936e-1333.99TNF receptor-associated factor 2-like [Source:NCBI... [more]
traf2b1.268e-1245.24TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf51.863e-1133.59TNF receptor-associated factor 5 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000002130.11.165e-1436.55pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 g... [more]
ENSPMAT00000000074.11.531e-1436.84pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-... [more]
traf65.939e-828.15TNF receptor-associated factor 6 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO487733.489e-1531.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO352371.966e-1236.22Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO388736.453e-1140.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO494641.743e-1041.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO258391.161e-935.06pep supercontig:ASM20922v1:NEMVEscaffold_10031:118... [more]
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BLAST of TNF receptor-associated factor 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
unm_sa8081.910e-1333.99TNF receptor-associated factor 2 [Source:NCBI gene... [more]
traf35.261e-1345.00TNF receptor associated factor 3 [Source:NCBI gene... [more]
ENSORLT00000020861.22.454e-1237.19TNF receptor-associated factor 2 [Source:NCBI gene... [more]
traf2b1.747e-1142.86TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf2b1.951e-1142.86TNF receptor associated factor 2 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000014397.10.000e+099.20SMESG000014397.1[more]
SMESG000014397.10.000e+099.19SMESG000014397.1[more]
SMESG000067208.11.218e-3248.74SMESG000067208.1[more]
SMESG000070126.12.167e-3229.55SMESG000070126.1[more]
SMESG000070130.12.237e-3229.36SMESG000070130.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002070 ID=SMED30002070|Name=TNF receptor-associated factor 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2234bp
TGTGAATTAATTGAATTGAACTTTTAAATTTTGGTTTATTTTTTCGGTTC
GGTTCAAGTGAAAGTTAACTTTGAAACTAAAAAAGGATATCATAATATTT
GCGAATATAAAAACTGATCATGGCAAGCCTGAAGTATTCTAAAATGTGGA
CCTTGCTGAATGAGTATAAATTTGAGGTGGATAATGATAAGAATCGCGAC
ATTATTTGCTGCATCTGCAAGAGCCTGCTGAAAAACGCTCAACAAAGCAT
TTGCGGTTGCGAATTCTGTTTCGACTGCATCAAGAATTACCTGTCGACTG
AATCCAAATTTTGTCCCGGTCGCAGTGCCGGCTGCAAGGAGCTGATGGTG
AACATCGAGCGCAACCTACAGGTAGATCACGCTGCCAATAAAAAGGTGGC
TAATGTCACCGTGAGGTGTCCAATAGACAATTGTGAATTCAGGACCGAGC
TCAAGGCCATGGACAGCCACATCGACAGCCACAATGACGTCGTTGACAGT
CAGGGAAAGTTCTTGCGGGAGCCGCTGGAAAAGCTGAAGAAGGAAATGAA
TGGACTGAAAGAAGGCCTGGACCAATGCAGAAAGGACTGCCTAAACAAAG
AGGTGGTCATAATGAAGATCCGTGAGGAAATAGACCGGTTCAGGAAGGCG
AGTGATGCTCAGGCAGTGGAAATCGGGATCCTGATCGATATGGCAAGGAG
AACTGAGAAGGTGAGTAGTGCTGGTAGCCACGGCAACGGTGATAACGGAA
ATCCGAAAATGGAGCCGAATATGATCATCAAGACCGCAATGGATGAGGAC
GAGATCGATTGGCAGCTGGAGATCCATTCGGATGAATTCGACGGGGATTT
GAATGTACGGCGAGATGGACAACTGGCACTCGTGGACCGGCACAATGGTG
CTGTCGATAGCAACGGCACTGCGGACTCAGAACGAGGACAATCGGGACCG
TTTCGGATGGGCAAGGAGATTCGGGAGCTGATAGGACTCGAGGTGCAGAA
GCAGCTGGACCGGCTGCAGAAATGGGCAGCCCGCAATAAACCGTTGCAAT
TTGCAGTCAACAATCAGGAACAGGACCAGGGACCGGCGGAACGGAGGGAA
TCGACACCTCTGGCACACCAGCAGACCGCCAATCCACAGCAGCCATCCTC
GTCGGAACCGACTCAAGAGGGCTCAACGGCACCTAGCAACAGTGGCGACA
GCGAAACCACGGATCAGTCAGCGAGGACCGTTCTCAAACCGGGCACTCGT
CGCAAATTGAATCGGGAGCTGCCCCAAGTCACTGCCAGTCCTGCAAAGGC
TAATCAGGAGCCACCAGCCAAAACTCCAACAGTATCAAAGGTGACGCCAG
CCCCGAAGCCAGGCAAGCCATTGAAGGCCAAGATCGTCACTACTAGCTCC
ACCAGACCAATCAAAGCTGTCACCACCACATTGCCCGGACGCGTTGCTAG
GAACCGTTTAGCGTTGCCAAGGAAACAACGAGGATTCGCTGCATCAATTC
CCCTGTTGTCAAGGTCGATCGATCCGATGCGGTGGATGCGCGAGATCGCC
CCATTTGAATTTATCATCAATAATTTCCATCAGAAGCACGCCAGAGCTCG
CCAGGGGCTCCCGATTGATAGTGTTAGCCCGCCGTTCTATTCTTCCGTGA
ACGGATATAAAATGTGCCTGCGTGTCGATCTCGGTGGGAATTTACCATTT
GATTCGCATCTCGGTGTGTTTTTCTGCGTAATGCGTGGGGAAAACGACGA
CGTTTTGCCCTGGCCCATGTGCTCAGAGGTCACCATCAGCCTCATGGACC
AGGTCGCGTTCGTCCCCTACACTAGTCGCACCTTTGATTTCCGATCGGCT
CCCAGCCAATGGAAATTTATTTTCGACCGCCCTTCAAATATTGATGGGCA
CCGCTGGTTCGGCACTCCCCAATTCGTGCATTTCGATTTTCTATTCAACA
ACCTGTCGCTGCTGTATAACGGTTCCATTATGATCCGTTGCTCCGTTGCT
ATTTGATTGGCCGGTGATAATCCATGTTTGTGATCAATTTTTTGATTTAT
CGATAATTAATATTCGATCGATGCTTGGTTTATCTATAATCAATAATTGA
TCAAATTTCAGATTTATCGAAAGTCAATATTTTTGATCGATTAAATCGGC
CAATTCTGCAGCGATAGAGTATTCTGGCGGCAGCGGCGGCATTAGCATTT
CACTGTAAATAAATATTTATTGATTGAAAAAAAA
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protein sequence of SMED30002070-orf-1

>SMED30002070-orf-1 ID=SMED30002070-orf-1|Name=SMED30002070-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=629bp
MASLKYSKMWTLLNEYKFEVDNDKNRDIICCICKSLLKNAQQSICGCEFC
FDCIKNYLSTESKFCPGRSAGCKELMVNIERNLQVDHAANKKVANVTVRC
PIDNCEFRTELKAMDSHIDSHNDVVDSQGKFLREPLEKLKKEMNGLKEGL
DQCRKDCLNKEVVIMKIREEIDRFRKASDAQAVEIGILIDMARRTEKVSS
AGSHGNGDNGNPKMEPNMIIKTAMDEDEIDWQLEIHSDEFDGDLNVRRDG
QLALVDRHNGAVDSNGTADSERGQSGPFRMGKEIRELIGLEVQKQLDRLQ
KWAARNKPLQFAVNNQEQDQGPAERRESTPLAHQQTANPQQPSSSEPTQE
GSTAPSNSGDSETTDQSARTVLKPGTRRKLNRELPQVTASPAKANQEPPA
KTPTVSKVTPAPKPGKPLKAKIVTTSSTRPIKAVTTTLPGRVARNRLALP
RKQRGFAASIPLLSRSIDPMRWMREIAPFEFIINNFHQKHARARQGLPID
SVSPPFYSSVNGYKMCLRVDLGGNLPFDSHLGVFFCVMRGENDDVLPWPM
CSEVTISLMDQVAFVPYTSRTFDFRSAPSQWKFIFDRPSNIDGHRWFGTP
QFVHFDFLFNNLSLLYNGSIMIRCSVAI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0001817regulation of cytokine production
GO:0008063Toll signaling pathway
GO:0032088negative regulation of NF-kappaB transcription factor activity
GO:0033209tumor necrosis factor-mediated signaling pathway
GO:0042981regulation of apoptotic process
GO:0045087innate immune response
GO:0050688regulation of defense response to virus
GO:0007165signal transduction
GO:0007250activation of NF-kappaB-inducing kinase activity
GO:0046330positive regulation of JNK cascade
Vocabulary: molecular function
TermDefinition
GO:0005164tumor necrosis factor receptor binding
GO:0046872metal ion binding
GO:0005515protein binding
GO:0008270zinc ion binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR043211TNF_rcpt-assoc_TRAF
IPR008974TRAF-like
IPR013083Znf_RING/FYVE/PHD
IPR002083MATH/TRAF_dom
IPR001841Znf_RING
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 136..156
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 388..403
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 310..414
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 329..371
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 258..278
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 460..627
coord: 14..126
NoneNo IPR availableCDDcd16449RING-HCcoord: 30..66
e-value: 1.28245E-7
score: 45.9213
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 13..67
IPR008974TRAF-likeGENE3DG3DSA:2.60.210.10coord: 453..628
e-value: 1.0E-31
score: 111.9
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 480..627
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 13..128
e-value: 4.4E-12
score: 48.0
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 460..627
coord: 14..126
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 30..66
score: 8.978
IPR002083MATH/TRAF domainPROSITEPS50144MATHcoord: 476..626
score: 9.831