Endothelin converting enzyme 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30002040 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275]) HSP 1 Score: 178.333 bits (451), Expect = 7.208e-46 Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S L + + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K + FY SC+ + RI+ + + I K G ++ F L+ FT+ S +S + N+ Q+ + ++L + EK T +E +L+ + + + L+ L I + + E + ++++ +L+ P+ DW + +L+ +PVV+ + + + +N E I+ NY W + + L + F S E+ L + Y +K + R C+ + +L SL+ + + + + E + +I+++F W+ + EK D++ I +P+ + + K + +I+++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+YN+Y L G LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 63 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275]) HSP 1 Score: 178.718 bits (452), Expect = 9.080e-46 Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S L + + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K + FY SC+ + RI+ + + I K G ++ F L+ FT+ S +S + N+ Q+ + ++L + EK T +E +L+ + + + L+ L I + + E + ++++ +L+ P+ DW + +L+ +PVV+ + + + +N E I+ NY W + + L + F S E+ L + Y +K + R C+ + +L SL+ + + + + E + +I+++F W+ + EK D++ I +P+ + + K + +I+++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+YN+Y L G LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 92 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 765
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275]) HSP 1 Score: 178.333 bits (451), Expect = 1.363e-45 Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S L + + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K + FY SC+ + RI+ + + I K G ++ F L+ FT+ S +S + N+ Q+ + ++L + EK T +E +L+ + + + L+ L I + + E + ++++ +L+ P+ DW + +L+ +PVV+ + + + +N E I+ NY W + + L + F S E+ L + Y +K + R C+ + +L SL+ + + + + E + +I+++F W+ + EK D++ I +P+ + + K + +I+++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+YN+Y L G LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 138 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275]) HSP 1 Score: 178.718 bits (452), Expect = 1.939e-45 Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S L + + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K + FY SC+ + RI+ + + I K G ++ F L+ FT+ S +S + N+ Q+ + ++L + EK T +E +L+ + + + L+ L I + + E + ++++ +L+ P+ DW + +L+ +PVV+ + + + +N E I+ NY W + + L + F S E+ L + Y +K + R C+ + +L SL+ + + + + E + +I+++F W+ + EK D++ I +P+ + + K + +I+++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+YN+Y L G LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 210 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECEL1 (endothelin converting enzyme like 1 [Source:HGNC Symbol;Acc:HGNC:3147]) HSP 1 Score: 167.933 bits (424), Expect = 3.139e-42 Identity = 156/697 (22.38%), Postives = 305/697 (43.76%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQ--NRKPSLFEEMT-NSMFNIG-------KRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEF----IAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQ--LFTLATSINSFDTVKNIPQISRPQVYLIQSLL----KEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMI--------DKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFR-SHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRL----KIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+DPC+DF F CG R +++T ++ IG +RL+++ K+R F++SC+++ I+R ++ + +ER + ++ +K+Q + LF+L S++ ++ + + +I + + L + L E ++ L R+ + + L ++LG E A I++ E + D L + S + + ++TL L++ P W + + D ++ + VV+ T + L R++ NY W + + E L FR + HE E + K +E R CL AN++F ++L +L+ Q L E+++ +++ W+ + K+ M + + YP+ + + + E ++++ +F N++N+++F+ + ++K + +NAYY+ +NQ+ P GI+Q ++ + Y IG IIGHE++HG+D G +D GNL + S +F + C V Y+ + + G LGENIAD L+++Y +++K +V + +Q+FF +A+ +C + R ++LTD H+P+ YR+LG S + F A+HC + + + KC +W
Sbjct: 120 IDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPG----VAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVL----SLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSM-YNKVTLGQLQKITPHLRWKWLLDQIFQ-EDFSEEEEVVLLATDYMQQVSQ-------LIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEG---------SDKPQELAR--------VCLGQANRHFGMALGALFVHE-----HFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLL-KPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQK---WVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 773
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-2 (Neprilysin-2 [Source:UniProtKB/Swiss-Prot;Acc:O44857]) HSP 1 Score: 172.555 bits (436), Expect = 2.265e-44 Identity = 167/694 (24.06%), Postives = 313/694 (45.10%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQ--------NRKPSL--FEEMTNSMFNIGKRLISQSNENYS------TKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPF--HQLFTLATSINSFDTVKNIPQISRPQVYLIQS--LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEY------MIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVI----KTCKVLEYYLNSKESFRIVENYFKWTTIFSML--ELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNX--XXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE--INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
VDPC DF F CGQ + PS+ FE + + K L+ +++E Y K + FY C+N + I L++++ + E + + +LG +K ++ + F LF + ++ +++ I +PQ+ L + +N+ ++ +++ + ++ A+ +LD A I+ FE M D+ + +EL + +ITL ++RR P F+W + + + DL + I V+ + + L+ + ++ R++ NY +W F + +L F LT F + KT ++ R + C+ N P++ +++Y VKN + +Q + ++ + E+ + S WLT K +K++ M+ I YP+ + D + K+ K+ ++ + + ++ L+ + E + +NA+Y N+I P GI+Q + + + + IG +IGHEI+HGFD G +D+ GN++ ++ KF+ + C ++Y+ Y L G GENIADN L+ +Y ++KK VN +Q+FF YA+++C K+ ++ T HSP R+ GP SNS F AY+CE +++ ++KC +W
Sbjct: 73 VDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETSAVGKAKYFYNLCLNESEI----LDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTRATLD---AKEIIDFETALANITMADEHRHDIAEL-YTKITLGEMRRSLPHFNWPLFFNRMFK--DLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDN-RLIVNYLEWCWFFKTMLRDLPDPF------------ALTIFKFYKTLNIMNVQK----VRWHGCVTRINSLMPMATSAIY---VKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-11 (Neprilysin-11 [Source:UniProtKB/Swiss-Prot;Acc:O16796]) HSP 1 Score: 160.229 bits (404), Expect = 5.127e-40 Identity = 103/371 (27.76%), Postives = 173/371 (46.63%), Query Frame = 1
Query: 1054 FENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKK----------TGGYVNKFDNQMFFFGYAKMFCNRPRKDGN-TRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
FE+I DF T +Q+ P R C Q+ + PL+ ++Y + + +++ +L + ++ + W+ K +EK +SM NI YP+V D + + I+ +D + ++ ++ L P +++ + +NA+Y ++N I P GI+Q P F Y IG +IGHEI+HGFD G +D GNL + ++SL F R C VE+Y Y +P G L GENIADN ++ ++ +++K G + Q+FF YA +C + ++ ++LTD HSP+ +R++G SN + F Y C R + KC +W
Sbjct: 485 FEDIKQDFLKVMTGQQQSPPRW------KDCAQVPSTVLPLAAGAIYVQA-HFQESDKHEALRMIMHLRNSFADLVRQNDWMDEETKAVAIEKANSMINNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYIMKKSVVWMQSREFQKLTKPFDKHEFDISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFPKAVNYGAIGAVIGHEITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKTNFRVNGKLTQGENIADNGGVKEAFQAYQKYVTENGEEPRLPGLQQYTNEQIFFVSYAHFWCGKKKEAAAMQQVLTDEHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-1 (Neprilysin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q18673]) HSP 1 Score: 155.606 bits (392), Expect = 9.614e-39 Identity = 117/408 (28.68%), Postives = 191/408 (46.81%), Query Frame = 1
Query: 961 RIVENY--FKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAK-TTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNL--KSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGG-------LELGENIADNTALEISYMSFK----KTGGYVNKF-------DNQMFFFGYAKMFCNRPRKDGNT-RILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
RIV NY +W +S E+ K + E++ +F++ KQR+P+ K ++ L A+ + + + ++ KN +L E R + ++ W+ K +EK D M I YP+ + + + + K ++ D F+ ++ ++NN + LL P+N + + +NA+Y RN I P GI+Q P F Y IG +IGHEI+HGFD G FD+ GNL+D T+ KF ERT C +E+Y + L G L GENIADN ++ ++ ++K K GG + + Q+FF GYA+++C + T +LTD HSP+ R+ +N F A+ C + + K+C +W
Sbjct: 368 RIVTNYILLRWAGSWSQ-EIGKKY----------EDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASG--SMYVRKYFDANAKNTTLDMIT------DLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEK-SIQWRNNFYYRRLLE-PVNRFEFISSAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-21 (Neprilysin-21 [Source:UniProtKB/Swiss-Prot;Acc:Q22523]) HSP 1 Score: 138.272 bits (347), Expect = 3.299e-33 Identity = 79/227 (34.80%), Postives = 118/227 (51.98%), Query Frame = 1
Query: 1492 LNGPLNE---YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYN-------EYNLPGGLELGENIADNTALEISYMSFKK-----TG-------GYVNKFDNQMFFFGYAKMFCNRPRKDGNTR-ILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
L+ PL+ + + +++AYY N++ P GI+Q P L + N Y +G +IGHE+SH FD G +D GNL D + KF E+T CFV +Y + +L G L LGENIADN ++ ++ ++K TG G+ N QMFF YA +C+ R + ILTD+H+P KYR + P N F A+ C + + ++KC +W
Sbjct: 543 LDQPLDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 769
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-21 (Neprilysin-21 [Source:UniProtKB/Swiss-Prot;Acc:Q22523]) HSP 1 Score: 138.272 bits (347), Expect = 3.299e-33 Identity = 79/227 (34.80%), Postives = 118/227 (51.98%), Query Frame = 1
Query: 1492 LNGPLNE---YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYN-------EYNLPGGLELGENIADNTALEISYMSFKK-----TG-------GYVNKFDNQMFFFGYAKMFCNRPRKDGNTR-ILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
L+ PL+ + + +++AYY N++ P GI+Q P L + N Y +G +IGHE+SH FD G +D GNL D + KF E+T CFV +Y + +L G L LGENIADN ++ ++ ++K TG G+ N QMFF YA +C+ R + ILTD+H+P KYR + P N F A+ C + + ++KC +W
Sbjct: 543 LDQPLDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 769
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0343930) HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40 Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query: 961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
R+V NY W + S++ + E + F IL +T R + C++ N+ +++ +L+ N ++ + + +R + + W+ + EK DSM I YPE++ + + ++ I ++F NN+++ +++ + L+ LL P+++ E +NA+Y +N I P GI+Q + + Y IG +IGHEI+HGFD G FD +GN+ ++ F+ERT C +++Y+ Y + G + GENIADN L+ ++ ++KK +N +Q+FF YA+++C R +D T+I + +HSP R+LGP SNS+ F SAY C + + +KC +W
Sbjct: 466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0070873) HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40 Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query: 961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
R+V NY W + S++ + E + F IL +T R + C++ N+ +++ +L+ N ++ + + +R + + W+ + EK DSM I YPE++ + + ++ I ++F NN+++ +++ + L+ LL P+++ E +NA+Y +N I P GI+Q + + Y IG +IGHEI+HGFD G FD +GN+ ++ F+ERT C +++Y+ Y + G + GENIADN L+ ++ ++KK +N +Q+FF YA+++C R +D T+I + +HSP R+LGP SNS+ F SAY C + + +KC +W
Sbjct: 466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0070872) HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40 Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query: 961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
R+V NY W + S++ + E + F IL +T R + C++ N+ +++ +L+ N ++ + + +R + + W+ + EK DSM I YPE++ + + ++ I ++F NN+++ +++ + L+ LL P+++ E +NA+Y +N I P GI+Q + + Y IG +IGHEI+HGFD G FD +GN+ ++ F+ERT C +++Y+ Y + G + GENIADN L+ ++ ++KK +N +Q+FF YA+++C R +D T+I + +HSP R+LGP SNS+ F SAY C + + +KC +W
Sbjct: 466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0340032) HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40 Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query: 961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
R+V NY W + S++ + E + F IL +T R + C++ N+ +++ +L+ N ++ + + +R + + W+ + EK DSM I YPE++ + + ++ I ++F NN+++ +++ + L+ LL P+++ E +NA+Y +N I P GI+Q + + Y IG +IGHEI+HGFD G FD +GN+ ++ F+ERT C +++Y+ Y + G + GENIADN L+ ++ ++KK +N +Q+FF YA+++C R +D T+I + +HSP R+LGP SNS+ F SAY C + + +KC +W
Sbjct: 466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep3 (gene:FBgn0031081 transcript:FBtr0307554) HSP 1 Score: 153.68 bits (387), Expect = 5.551e-38 Identity = 86/302 (28.48%), Postives = 155/302 (51.32%), Query Frame = 1
Query: 1255 LTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFKKTGG----------YVNKFDNQMFFFGYAKMFCNRPRKDGN-TRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ E ++ +++ W+ +++ +EK + + I +P+ + D + + I N +F N I +N K+NLK L + P+N+ G +NAYY +NQI P GI+Q P F +N + +G ++GHE++H FD G +D GN+ S+ +F E++ C +Y+ Y L G LGENIADN L+ +Y ++++T +N +Q+FF +A+++C+ + N ++ D HSP ++R++G SN K F + C+ ++ +KC +W
Sbjct: 486 IREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRL-DQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ece2b (endothelin converting enzyme 2b [Source:ZFIN;Acc:ZDB-GENE-131120-140]) HSP 1 Score: 192.586 bits (488), Expect = 1.411e-50 Identity = 175/715 (24.48%), Postives = 316/715 (44.20%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S+ L VT+ SKI+ ++ R DPC+DF ++ CG +N P S F + + + K L+ N S+ K +++Y SC+N RI+ + I K KE F L+ FT++ S++ ++ N+ Q+ + ++L S N+T ++ + ++ + + G+ G + I+ FE + + E E+ IT+ DL+ PA +W + +L +PVV+ AK ++ +V E L +K ++ NY W LV+ S ++ FEN + K + +K R C+ + +L +L+ + + + + E + +I+++F W+ + +K D++ I +P+ + D K + ++ +++FF NMIN F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D GNL+ +S+ FK RT C V++Y +Y ++ G LGENIADN L+ +Y +++ K G VN ++Q+FF G+A+++C+ R + + ++TD HSP KYR++G SNS F + C + + +C +W
Sbjct: 93 SICLTEACVTVASKIV-------EALDRSADPCQDFYQYACGGWVRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAERKTQSYYLSCLNEQRIEELGAQPL----MDLITKIGGWNITESWDKENFLDVLKIISGPYRAQPFFTVSVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLDYMVELGLLLGGDKNSTRGQMQQILDFETALANITVPQDERRDEEKIYHKITIADLQVLAPAIEWLDYLNSVLSPLELNDTEPVVVY---AKEYMQ--QVSE--LINKTDHSLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSK---------EIAEGMINEIRTAFKGALDDLKWMDEQTRQAAKDKADAIYDMIGFPDFILDSKELDDVYDGYEVTEDNFFQNMINFYNFSARVMADQLRKPPNRDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAQDHPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWQNSSVEAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQKNGEEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSGHRCEVW 765
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ecel1 (endothelin converting enzyme-like 1 [Source:ZFIN;Acc:ZDB-GENE-130530-692]) HSP 1 Score: 169.474 bits (428), Expect = 2.252e-43 Identity = 172/674 (25.52%), Postives = 308/674 (45.70%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQN-RKPSLFEEMTNS--MFNIG-------KRLIS-----QSNENYSTKLRNFYKSCINLNRIKR-------KSLNSFKYWYQEFIAKYKERQTLGRT-IKEQFQSQLEFFKSQPPFHQ--LFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLI-KWANVLG---------ESLD-ENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVI----QMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLY-----SSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLN--GPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYR 2007
V PC DF F CG R+ + E+ + + IG +RL+ + E+ K++ FY+SCIN+ I R + ++S W G I+ F L +K+Q + F+L S++ ++ +N +I + + L + L Q + +K + K L+ + ++LG E LD E NI EY D+ SS + +ITLK L++ P+F W + +N + ++ + +V+ M + +IKT S R++ NY W + ++ E + T F + + +FS +++ L E CL AN++F ++L +L+ SSS + + ++ +++ +L ++++ W+ KD K+ M + YP+ + + I E + +N+ +F N++N++K+N K ++K + +NAYY+ +NQ+ P GI+Q ++ Y IG IIGHE++HG+D G +D GNLK + S RKF+++T C V+ Y+ + + G L LGENIAD L++SY +++K +V + Q+FF +A+ +C + R ++LTD H+P+ YR
Sbjct: 42 VQPCHDFYSFACGGWLRRHGIPEDKLSYGIITAIGEQNQDKLQRLLQAPVQRRELESAERKVKEFYRSCINIKEIDRLGAGPMTEVIDSCGGWDLSGAPPGGAGWDSGSAPIRPDFNEML--YKTQGVYSTSVFFSLTVSVDDKNSSRNAIRIDQEGLTLPERTLY-LGQDEDSVKILASYKALMERLLSMLGAHNATLKSREILDLETKLANITVSEYE-DQRKDISSM--YNRITLKQLQKMAPSFHWKRLLDRIFN-DNFSEEEEIVVLATDYMQTVSDIIKTT-----------SKRVLHNYMLWRMVAALSEHLSTA---------FRSTIHEFSREIDGTEQQ------LDLERLCLTQANKHFGMALGALFVQQHFSSSSR------AKVQELVEDIKHSLDVRLQELDWMDEETKDAARGKLQHMMVMTGYPDFLLKPELI-DEEYAFDVNEKTYFKNILNSIKYNIKLSIKKIHKEVDKTTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPEFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRYGNLKQWWTEESYRKFQKKTECIVKLYDNFTVYNQRVNGRLTLGENIADLGGLKLSYHAYQK---WVREHGPERPLPGLKHTHEQLFFIAFAQNWCMKRRSQSIYLQLLTDKHAPEHYR 672
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ece1 (endothelin converting enzyme 1 [Source:ZFIN;Acc:ZDB-GENE-061110-100]) HSP 1 Score: 166.392 bits (420), Expect = 4.747e-42 Identity = 176/711 (24.75%), Postives = 307/711 (43.18%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP----------SLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFE-----YMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSF----KKTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
V++ S +L S R VDPC+DF F CG +N P +L+E M N+ + +S K + +Y++C+N ++I+ Q+ I + G K+ FQ L + FT+ S +S + NI Q+ + + L L K N+ L L++ +LG S D + + I++FE + ++ E + +I K+L PA DW + +L +PVV+ AK ++ KV E N+ +S ++ NY + M+ ++ + E + E + T K P+ KL ++ + L A L + + +S K E++ +IK +F W+ K EK D++ + YP+ + + K + + + +F N++N F+ + L P + + T +NAYY +N++ +P GI Q P + + IG ++GHE++H FD G +D GNL +S+ F+ +T C VE+Y+ Y+ L G LGENIADN L +Y ++ KK G + ++Q+FF G+A+++C+ R + + ++TD HSP ++R++G SNS F + C+ + + K+KC LW
Sbjct: 87 VSVASAVLGSL-------DRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKIEELGAKPL----QDLINQTGGWGLKGPWEKDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNF----LVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPFLSSVFAPVELNDSEPVVVY---AKEYLQ--KVSELISNTNKS--VLNNYMIMKVVRKMVSILDQ-KFQDAEQRFLEVMY------GTKKSCMPRWKLCVSDTDSALGFA--LGALFVKATFSEDSK--------------AFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ece1 (endothelin converting enzyme 1 [Source:ZFIN;Acc:ZDB-GENE-061110-100]) HSP 1 Score: 166.392 bits (420), Expect = 4.747e-42 Identity = 176/711 (24.75%), Postives = 307/711 (43.18%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP----------SLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFE-----YMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSF----KKTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
V++ S +L S R VDPC+DF F CG +N P +L+E M N+ + +S K + +Y++C+N ++I+ Q+ I + G K+ FQ L + FT+ S +S + NI Q+ + + L L K N+ L L++ +LG S D + + I++FE + ++ E + +I K+L PA DW + +L +PVV+ AK ++ KV E N+ +S ++ NY + M+ ++ + E + E + T K P+ KL ++ + L A L + + +S K E++ +IK +F W+ K EK D++ + YP+ + + K + + + +F N++N F+ + L P + + T +NAYY +N++ +P GI Q P + + IG ++GHE++H FD G +D GNL +S+ F+ +T C VE+Y+ Y+ L G LGENIADN L +Y ++ KK G + ++Q+FF G+A+++C+ R + + ++TD HSP ++R++G SNS F + C+ + + K+KC LW
Sbjct: 87 VSVASAVLGSL-------DRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKIEELGAKPL----QDLINQTGGWGLKGPWEKDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNF----LVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPFLSSVFAPVELNDSEPVVVY---AKEYLQ--KVSELISNTNKS--VLNNYMIMKVVRKMVSILDQ-KFQDAEQRFLEVMY------GTKKSCMPRWKLCVSDTDSALGFA--LGALFVKATFSEDSK--------------AFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: phex (phosphate regulating endopeptidase homolog, X-linked [Source:ZFIN;Acc:ZDB-GENE-030103-2]) HSP 1 Score: 156.377 bits (394), Expect = 6.545e-39 Identity = 132/498 (26.51%), Postives = 224/498 (44.98%), Query Frame = 1
Query: 715 MKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYY------LNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKI-----KSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTG-FEINAYYIFQRNQINVPMGIIQGPIF-QLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-------NLPGGLELGENIADNTALEISYMSF-----KKTGGY-------VNKFDNQMFFFGYAKMFCNRPRKD-GNTRILTDLHSPDKYRILGPTSNSKTFESAYHC-ERXXXXXXXXXCHLW 2103
MK ++ +SE + + +L L+R P F+W + + LK ++S++ VI + +Y+ +N+ ++ R V NY W ++FS + + R +L F + T TT K + EN + A + F + + K++ + L +R K + W+ K + ++K ++ + YP+ + + +I K + D+F N++ +KF ++++ L P E+FT +NA+Y NQI P G +Q P F LN Y IG I+GHE++HGFD+ G +D GNL +S+ +F E+T C +++YN Y N+ G L ENIADN + S+ ++ K+ GG V NQ+FF YA + CN R + +I + HSP KYR++G SN + F A++C E + + C +W
Sbjct: 258 MKLAQIVIPYENRTSENMYNKYSLSKLQRTVPDFNWLGFVRAVIDTELYPDLK-----ISSSEQVI--VRAPQYFKDLFKLINATDT-RTVANYVIWRSVFSRITTLS--RRFLYRYLDFARVTTG-----TTSLTPRWDKCVNYVENTLIYAAGRLF---VDKHFQEDKKHMME----------ELINGIRWAFIDILEKENEWMDEETKRKAIDKAHAVLPKVGYPDFILNDTYINEDIKRLAFTMTDYFGNVMQTLKFIAQSDIGWLRKTVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTHGFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGGIRESFRAYRRWVEKERGGVEEPLLPGVGLTHNQLFFLSYAHVRCNAYRPEAARDQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMNRGAESCRVW 727
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142]) HSP 1 Score: 197.593 bits (501), Expect = 3.490e-52 Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L V++ +IL S R +DPC+DF ++ CG R P + F + + I K ++ + N S+ K + FY SC+ RI ++K L + I K G E F S L+ F++ S +S + NI Q+ + ++L L K N L+ + ++ +LG S G+++ I++FE ++ L E E+ +T+ +L+ PAFDW + DL +PVV+ K ++ L +N+ + ++ NY W + M + S E+ ++ L + Y +K R CL + +L SL+ S + + N+ E + +I+ +F W+ + EK D++ I +P+ + D K + +++++ FF NM+N F+ K + L P E + T +NAYY+ +N+I P GI+Q P + + IG ++GHE++H FD G +D GNL+ +SL FK RT C V +YN Y + G G + LGENIADN L+ +Y ++K K V +NQ+FF G+A+++C+ R + + ++TD HSP K+R++G SNSK F ++C + + K C +W
Sbjct: 82 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 755
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142]) HSP 1 Score: 196.438 bits (498), Expect = 3.953e-52 Identity = 190/729 (26.06%), Postives = 321/729 (44.03%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFI----LIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L V++ +IL S R +DPC+DF ++ CG R P + F + + I K ++ + N S+ K + FY SC+ RI ++K L + I K G E F S L+ F++ S +S + NI Q+ + ++L L K N L+ + ++ +LG S G+++ I++FE ++ L E E+ +T+ +L+ PAFDW + DL +PVV+ K ++ L +N+ + ++ NY W + M + S E+ ++ L + Y +K R CL + +L SL+ S + + N+ E + +I+ +F W+ + EK D++ I +P+ + D K + L++ + K++++ FF NM+N F+ K + L P E + T +NAYY+ +N+I P GI+Q P + + IG ++GHE++H FD G +D GNL+ +SL FK RT C V +YN Y + G G + LGENIADN L+ +Y ++K K V +NQ+FF G+A+++C+ R + + ++TD HSP K+R++G SNSK F ++C + + K C +W
Sbjct: 8 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDETGLLY--TAKVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 683
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142]) HSP 1 Score: 197.593 bits (501), Expect = 4.554e-52 Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L V++ +IL S R +DPC+DF ++ CG R P + F + + I K ++ + N S+ K + FY SC+ RI ++K L + I K G E F S L+ F++ S +S + NI Q+ + ++L L K N L+ + ++ +LG S G+++ I++FE ++ L E E+ +T+ +L+ PAFDW + DL +PVV+ K ++ L +N+ + ++ NY W + M + S E+ ++ L + Y +K R CL + +L SL+ S + + N+ E + +I+ +F W+ + EK D++ I +P+ + D K + +++++ FF NM+N F+ K + L P E + T +NAYY+ +N+I P GI+Q P + + IG ++GHE++H FD G +D GNL+ +SL FK RT C V +YN Y + G G + LGENIADN L+ +Y ++K K V +NQ+FF G+A+++C+ R + + ++TD HSP K+R++G SNSK F ++C + + K C +W
Sbjct: 91 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 764
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142]) HSP 1 Score: 197.208 bits (500), Expect = 5.349e-52 Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L V++ +IL S R +DPC+DF ++ CG R P + F + + I K ++ + N S+ K + FY SC+ RI ++K L + I K G E F S L+ F++ S +S + NI Q+ + ++L L K N L+ + ++ +LG S G+++ I++FE ++ L E E+ +T+ +L+ PAFDW + DL +PVV+ K ++ L +N+ + ++ NY W + M + S E+ ++ L + Y +K R CL + +L SL+ S + + N+ E + +I+ +F W+ + EK D++ I +P+ + D K + +++++ FF NM+N F+ K + L P E + T +NAYY+ +N+I P GI+Q P + + IG ++GHE++H FD G +D GNL+ +SL FK RT C V +YN Y + G G + LGENIADN L+ +Y ++K K V +NQ+FF G+A+++C+ R + + ++TD HSP K+R++G SNSK F ++C + + K C +W
Sbjct: 93 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 766
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142]) HSP 1 Score: 195.667 bits (496), Expect = 1.335e-51 Identity = 189/725 (26.07%), Postives = 317/725 (43.72%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L V++ +IL S R +DPC+DF ++ CG R P + F + + I K ++ + N S+ K + FY SC+ RI ++K L + I K G E F S L+ F++ S +S + NI Q+ + ++L L K N L+ + ++ +LG S G+++ I++FE ++ L E E+ +T+ +L+ PAFDW + DL +PVV+ K ++ L +N+ + ++ NY W + M + S E+ ++ L + Y +K R CL + +L SL+ S + + N+ E + +I+ +F W+ + EK D++ I +P+ + D K + E ++++ FF NM+N F+ K + L P E + T +NAYY+ +N+I P GI+Q P + + IG ++GHE++H FD G +D GNL+ +SL FK RT C V +YN Y + G G + LGENIADN L+ +Y ++K K V +NQ+FF G+A+++C+ R + + ++TD HSP K+R++G SNSK F ++C + + K C +W
Sbjct: 59 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTK--ELDEVYDGVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 730
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Ece2 (endothelin converting enzyme 2 [Source:MGI Symbol;Acc:MGI:1101356]) HSP 1 Score: 182.57 bits (462), Expect = 2.823e-47 Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K R+FY SC+ RI++ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L S N+T E +++ +LG E + + L I + + E + ++++ +L+ PA DW + +L +PVV+ T + + + +N E I+ NY W + KT S + + L + Y +K R C+ + +L SL+ + + + + E + +I+S+F T D K RL EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y + G GL+ LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 98 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Ece2 (endothelin converting enzyme 2 [Source:MGI Symbol;Acc:MGI:1101356]) HSP 1 Score: 182.185 bits (461), Expect = 3.009e-47 Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K R+FY SC+ RI++ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L S N+T E +++ +LG E + + L I + + E + ++++ +L+ PA DW + +L +PVV+ T + + + +N E I+ NY W + KT S + + L + Y +K R C+ + +L SL+ + + + + E + +I+S+F T D K RL EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y + G GL+ LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 69 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 734
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Gm49333 (predicted gene, 49333 [Source:MGI Symbol;Acc:MGI:6121518]) HSP 1 Score: 182.57 bits (462), Expect = 6.129e-47 Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K R+FY SC+ RI++ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L S N+T E +++ +LG E + + L I + + E + ++++ +L+ PA DW + +L +PVV+ T + + + +N E I+ NY W + KT S + + L + Y +K R C+ + +L SL+ + + + + E + +I+S+F T D K RL EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y + G GL+ LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 216 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 881
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Gm49333 (predicted gene, 49333 [Source:MGI Symbol;Acc:MGI:6121518]) HSP 1 Score: 182.57 bits (462), Expect = 8.408e-47 Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K R+FY SC+ RI++ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L S N+T E +++ +LG E + + L I + + E + ++++ +L+ PA DW + +L +PVV+ T + + + +N E I+ NY W + KT S + + L + Y +K R C+ + +L SL+ + + + + E + +I+S+F T D K RL EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y + G GL+ LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 245 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Ece1 (endothelin converting enzyme 1 [Source:MGI Symbol;Acc:MGI:1101357]) HSP 1 Score: 178.718 bits (452), Expect = 5.622e-46 Identity = 167/718 (23.26%), Postives = 307/718 (42.76%), Query Frame = 1
Query: 103 LILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYSTKLRN---FYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILIN--KQLIKWANVLGESLDENG----ALNIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSF----KKTGG-----YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
L V++ S IL+S VDPC+DF + CG N P F + + K L+ + + S R +Y++C+N RI+ E I K G K+ FQ L+ + F++ S +S ++ N+ Q+ + + L ++ K E +++L +++ +LG DE+ I+ FE + + EL + ++T +L+ PA +W + I+Y V ++ + +P+V+ K ++ L +N+ + ++ NY W + L + F+ E+ + + Y +K + R FC+ +L ++ + + +N+ + ++IK +F W+ + EK D++ I YP + D K + + +F N + F+++ L P + + T +NAYY +N+I P GI+Q P + + N + IG ++GHE++H FD G +D GNL+ +S+ FK++T C V++Y+ Y++ G LGENIADN L+ +Y ++ KK G + NQ+FF G+A+++C+ R + + ++TD HSP ++R++G SNSK F + C + + KC +W
Sbjct: 83 LTEACVSVTSSILNSMDPT-------VDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKAQVYYRACMNETRIEELRAKPL----MELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS---RDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-DEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV-EINESEPIVVY---DKEYLRQVSTL---INNTDKC-LLNNYMMWNLVRKTSSFLDQRFQDADEKFM-------EVMYG--------TKKTCIPRWKFCVSDTENNLGFALGPMFVKAT---------FAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 753
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|P42891|ECE1_BOVIN (Endothelin-converting enzyme 1 OS=Bos taurus OX=9913 GN=ECE1 PE=1 SV=2) HSP 1 Score: 189.504 bits (480), Expect = 9.376e-49 Identity = 174/720 (24.17%), Postives = 308/720 (42.78%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYSTKLRN---FYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILIN--KQLIKWANVLGESLDEN---GALNIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSF----KKTGG-----YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S+ L +++ S ILSS VDPC+DF + CG N P F + I K L+ S + S R +Y++C+N RI+ E I K G K+ FQ L+ S F++ S +S ++ N+ Q+ + + L ++ K E +++L +++ +LG ++ I+ FE + + EL + ++T +L+ PA +W + I+Y V ++ + +P+VI S + T +NS + ++ NY W + L + F+ E+ + + Y +K L R FC+ +L ++ + + +N+ + L+IK +F W+ + EK D++ I YP + D K + + +F N + F+++ L P + + T +NAYY +N+I P GI+Q P + + N + IG ++GHE++H FD G +D GNL+ +S+ FK++T+C VE+Y Y++ G LGENIADN L+ +Y ++ KK G + +NQ+FF +A+++C+ R + + ++TD HSP ++R++G SNSK F +HC + + KC +W
Sbjct: 81 SVCLSEACISVTSSILSSMDPT-------VDPCQDFFTYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELKAKPL----MELIEKLGGWNITGPWDKDNFQDTLQVVTSHYHTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS---RDYYLNKTENEKVLTGYLNYMVQLGKLLGGGAEDTIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV-EINESEPIVIYDKEYLSKVSTL------INSTDKC-LLNNYMIWNLVRKTSSFLDQRFQDADEKFM-------EVMYGT--------KKTCLPRWKFCVSDTENTLGFALGPMFVKAT---------FAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTACMVEQYGNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLSFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSISNSKEFSEHFHCPPGSPMNPHHKCEVW 754
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|B2RQR8|ECE2_MOUSE (Endothelin-converting enzyme 2 OS=Mus musculus OX=10090 GN=Ece2 PE=1 SV=1) HSP 1 Score: 182.57 bits (462), Expect = 1.975e-46 Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K R+FY SC+ RI++ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L S N+T E +++ +LG E + + L I + + E + ++++ +L+ PA DW + +L +PVV+ T + + + +N E I+ NY W + KT S + + L + Y +K R C+ + +L SL+ + + + + E + +I+S+F T D K RL EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y + G GL+ LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 98 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|P42893|ECE1_RAT (Endothelin-converting enzyme 1 OS=Rattus norvegicus OX=10116 GN=Ece1 PE=1 SV=2) HSP 1 Score: 182.185 bits (461), Expect = 2.978e-46 Identity = 172/713 (24.12%), Postives = 307/713 (43.06%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST---KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILIN--KQLIKWANVLGESLDENG----ALNIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSF----KKTGG-----YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
V++ S IL+S VDPC+DF + CG N P F + I K L+ S + S K + +Y++C+N RI+ E I K G K+ FQ L+ + F++ S +S ++ N+ Q+ + + L ++ K E +++L +++ +LG DE+ I+ FE + + EL + ++T +L+ PA +W + I+Y V ++ + +P+V+ K ++ L +NS + ++ NY W + L + F+ E+ + + Y +K L R FC+ +L ++ + + +N+ + L+IK +F W+ + EK D++ I YP + D K + + +F N + F+ + L P + + T +NAYY +N+I P GI+Q P + + N + IG ++GHE++H FD G +D GNL+ +S+ FK++T C V++YN Y++ G LGENIADN L+ +Y ++ KK G + NQ+FF G+A+++C+ R + + ++TD HSP ++R++G SNSK F + C + + + KC +W
Sbjct: 97 VSVTSSILNSMDPT-------VDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPL----MELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS---RDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-DEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPV-EINESEPIVVY---DKEYLRQVSTL---INSTDKC-LLNNYMMWNLVRKTSSFLDQRFQDADEKFM-------EVMYGT--------KKTCLPRWKFCVSDTENNLGFALGPMFVKAT---------FAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 762
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|P0DPD9|EFCE2_MOUSE (EEF1AKMT4-ECE2 readthrough transcript protein OS=Mus musculus OX=10090 GN=Eef1akmt4-Ece2 PE=1 SV=1) HSP 1 Score: 182.57 bits (462), Expect = 4.287e-46 Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query: 118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K R+FY SC+ RI++ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L S N+T E +++ +LG E + + L I + + E + ++++ +L+ PA DW + +L +PVV+ T + + + +N E I+ NY W + KT S + + L + Y +K R C+ + +L SL+ + + + + E + +I+S+F T D K RL EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y + G GL+ LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 216 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 881
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|F1N476|ECE2_BOVIN (Endothelin-converting enzyme 2 OS=Bos taurus OX=9913 GN=ECE2 PE=2 SV=1) HSP 1 Score: 179.104 bits (453), Expect = 3.231e-45 Identity = 169/720 (23.47%), Postives = 302/720 (41.94%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
S L + + KIL +S R V PC+DF +F CG R P + F + + I K L+ + N S+ K + FY SC+ + RI+ + + I K G ++ F L+ FT+ S +S + NI Q+ + ++L + EK T +E +L+ Q + + L+ L I + + E + ++++ +L+ P+ DW + +L +PVV+ T + L ++ ++ NY W + + L F S E+ L + Y +K R C+ + +L SL+ + + + + E + +I+++F W+ + EK D++ I +P+ + + K + +++++ FF NM+N F+ K L P + + T +NAYY+ +N+I P GI+Q P + N + IG ++GHE++H FD G +D +GNL+ SL F+ T+C E+Y++Y L G LGENIADN L+ +Y ++K K G V ++Q+FF G+A+++C+ R + + ++TD HSP ++R+LG SNS+ F + C + + + C +W
Sbjct: 92 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTQRFYLSCLQVERIEELGAQPLR----DLIDKIGGWNVTGPWDQDNFMEVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGQPTSTREQMRQVLE----LEIQLANITVPQDQRRDEEKIYHKMSIAELQALAPSMDWLEFLSFLLSPLELGDSEPVVVYGTDYLQQVSE-------LINRTEPSVLNNYLIWNLVQKTTSSLDHRFESAQEK-------LLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRAAFEEALGHLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYTCNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACIEEQYSQYQVNGEKLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNSGQLCEVW 765
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: A0A336KGD2 (CSON003355 protein OS=Culicoides sonorensis OX=179676 GN=CSON007349 PE=4 SV=1) HSP 1 Score: 203.756 bits (517), Expect = 1.531e-50 Identity = 183/726 (25.21%), Postives = 326/726 (44.90%), Query Frame = 1
Query: 73 KSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG---------QNRKP-SLFEEMTNSMFNIGKRLISQS---NENYST-KLRNFYKSCINLNRIKRKSLNSF--KYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-IMKFEYMIDKLWGESSELG-----FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQ----MTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
K+ N+ ++ L VT S +LS+ R DPCKDF +F CG ++R S FE + + I K ++ + N+N +T K + FYKSC++L +I++ + F Y ++ T E +L S+P + + A NS NI Q+ + + L K+ ++ ++K ++ + + A +LG S D LN I++FE + ++ + ++TL +L + P DW + L + +PVV+ + S ++KT R + NY W SM+ + E + F IL + R + C++ N+ +++ +L+ N ++ + I N+ E + W+ + EK D+M I YPE++ + + ++ I++N+F NN++N ++++ N++ LL P+++ E +NA+Y +N I P GI+Q + N Y IG +IGHE++HGFD G FD GN+ +++ F+ER C +++Y+ Y + G + GENIADN L+ ++ +++K +V+K +Q+FF YA+++C R +D T+I + +HSP R++GP SNSK F AY+C + + KC +W
Sbjct: 187 KNSNDNTNICLTEDCVTAASSLLSAM-------DRTADPCKDFFQFACGVWNKKHLIPEDRSSISTFEVLADQQQVILKGVLEEPLDENDNKATIKAKMFYKSCMDLQQIRKIGIQPFLDVLKYLGGWPVIEKNWTAPNFSIEWLMGRLRGEFSEPVLIEFYVGADDKNS---SSNILQLDQLVLALPSRDYYLKSSSEGDLK--AYHRYMTQIARLLGASSDAYKELNDIIQFEIRLANASSPEADRHDTSAIYRKLTLTELAKEVPEIDWREYLQETVGDIKLKRDEPVVVYALPYLVSLGKILKTT-----------DRRTIHNYLLWRLTMSMM--THMIDEYQRERVEFRKILLGIQSERH-------------RWSQCVEWTNKKLGMAVGALFIRDNFNQVSKETALEMIH-NIREAFNELLADIHWMDDETRAVAKEKADAMNERIGYPEILTNPPELEKEYVNLTIDENNFLNNVLNILRWDAHRNMQ-LLRKPVDKNKWATEPAVVNAFYNPNKNDIVFPAGILQPLFYSQNFPKSLNYGGIGVVIGHEVTHGFDDKGRQFDKDGNMMQWWNNATIKAFRERAQCIIDQYSRYKIDEVGLYMNGRMTQGENIADNGGLKQAFRAYRK---WVDKHGPEARLPGLNLTHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGIIRVIGPLSNSKDFAEAYNCPLGSPMNPTSKCSVW 869
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: W8BVC8 (Membrane metallo-endopeptidase-like 1 OS=Ceratitis capitata OX=7213 GN=MMEL1 PE=2 SV=1) HSP 1 Score: 202.601 bits (514), Expect = 3.975e-50 Identity = 191/735 (25.99%), Postives = 334/735 (45.44%), Query Frame = 1
Query: 109 LLIVTIGSKILSSSKKDGKSNQRFV---------------------DPCKDFNRFVCG---------QNRKP-SLFEEMTNSMFNIGKRLISQS---NENYST-KLRNFYKSCINLNRIKR-------KSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFEY-MIDKLWGES----SELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFS-MLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKK---------TGGYVNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
L + ++GS + +++K D K QR V DPC +F +F CG ++R S FE +++ + K ++ +S ++N +T K + FYKSC++L +I++ L S W Q TI EQ L S+P +L+ A NS NI QI +PQ+ L K ++ ++K L K + + A +LG S G +++FE +++ E+ + + +ITL +L+R P +W + + D+ L ++ + +++ K+LE K R+V N+ W + S M ++ F+ E + F IL + R + C++ N+ L++ +L+ N + + I L E + + W+ + EK ++M I YPE++ + + +++ I ++F N++N +K++ + NL+ LL+ P+++ E +NA+Y +N I P GI Q + N Y IG +IGHEI+HGFD G FD GN+ ++ F+ERT C +++Y+ Y + G + GENIADN L+ ++ ++KK +N +Q+FF YA+++C R +D T+I + +HSP R+L P SNSK F AY C+ + + +KC +W
Sbjct: 184 LTMASVGSSVQAATK-DIKPRQRDVCLTEDCVRTAASLLSAMDTTADPCTNFFQFACGTWNKIHIIPEDRSSISTFEVLSDEQQVVLKGVLEESIKDDDNIATIKAKQFYKSCMDLPQIRKIGEGRLMDVLKSLGGWP----VITPNWQPPNMTI-EQLMGILRGVYSEPVLVELYVGADDKNS---SINILQIDQPQLALPSRDYYLKPSSENDLKAYL--KYMTQTAILLGASPATAGKELDEVLQFEIKLVNASLPEADRHDTSAIYNKITLPELQRQVPQLNWTVFLQTVLG-PDIELLPDELLVSYAMPYLVEMGKILE-----KADRRVVHNFVIWRLVMSIMAHMIDEFQ---RERIEFRKILLGVQSERM-------------RWSQCVEWTNKKLGLAVGALFIRDNFNQESKDTALEMIH-TLREAFNELLTENHWMDDETRAVAREKANAMNERIGYPEILNNATELAKEYENLTIVPDNFMENVLNILKWDSEKNLQ-LLHQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGIFQPLFYSNNYPKSVNYGGIGVVIGHEITHGFDDKGRQFDKDGNMMQWWNNATIEAFRERTQCIIDQYSRYKIEEVDMYVNGRMTQGENIADNGGLKQAFRAYKKWVKRHGPEPELPGLNLTHDQLFFLNYAQIWCGSMRPEDAVTKIRSSVHSPGFIRVLAPLSNSKDFAEAYKCKLGSPMNPVEKCSVW 883
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: Q17AS1 (AAEL005207-PA OS=Aedes aegypti OX=7159 GN=5566104 PE=4 SV=1) HSP 1 Score: 198.749 bits (504), Expect = 5.075e-49 Identity = 179/687 (26.06%), Postives = 321/687 (46.72%), Query Frame = 1
Query: 175 RFVDPCKDFNRFVCGQ-NRKP---------SLFEEMTNSMFNIGKRLISQS---NENYST-KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIA--KYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG--ESLDENGALNIMKFEYMI------DKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKY-----NEYNL--PGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
R VDPCKDF +F CG N+K S FE + + I K ++ +S N+N +T K + FYKSC++L +I++ +N + + ++ L T E L S+P +L+ A NS KNI QI + + L K ++ ++K + + + A +LG ++ + ++ FE + + ++S + +++ITL+ L++ P +W + L + + +V + +I+ ++L + K RI+ NY W + S++ + +E + F IL + R + C++ N+ +++ +L+ N ++ + I + E + W+ + EK D+M I YPE++ + + + ++ I K+ F NN++N +K++ + NL+ LL P+++ E +NA+Y +N I P GI+Q + + Y IG +IGHEI+HGFD G FD GN+ +++ F+ER C +++Y NE NL G + GENIADN L+ S+ +++K + +N +Q+FF YA+++C R +D T+I + +HSP R++GP SNSK F AY+C + + KC +W
Sbjct: 170 RTVDPCKDFFQFACGTWNKKHVIPEDRSSISTFEVLADQQQVILKGVLEESVDVNDNQATLKAKMFYKSCMDLQQIRKIGINPIRNVLKSLGGWPVIEQNWVLPNTSIEHLIGTLRGVYSEPVLVELYVGADDKNS---SKNILQIDQLVLALPSRDYYLKQSSEGDLKAY--HHYMTQIAILLGGDPTIASKELMEVINFEVRLANASLPEADRHDTSAI-YKKITLQQLQKQVPQINWKEYLQTTLGSVKLEENEAIV--SYAMPYLIEMGRILN--MTDK---RIIHNYAIWRFVMSIM--THMIDDYQKERVEFRKILLGIQSERH-------------RWSQCVEWTNKKLGMAVGALFIRDNFNQESKETALEMIH-TIREAFNELLADIHWMDDETRAVAKEKADAMNERIGYPEILTNPEELEKEYINLTIFKDHFINNILNILKWDAERNLQ-LLRKPVDKDKWATEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKDGNMMQWWNNATIKAFRERAQCIIDQYSRYKINEVNLFMNGRMTQGENIADNGGLKQSFRAYRKWVDFHGPELDLPGMNMSHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGIIRVIGPLSNSKDFAEAYNCPYGSPMNPLNKCSVW 826
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: F7E009 (Dehydrodolichyl diphosphate synthase subunit OS=Xenopus tropicalis OX=8364 GN=guca1c PE=4 SV=2) HSP 1 Score: 197.593 bits (501), Expect = 5.479e-49 Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L V++ +IL S R +DPC+DF ++ CG R P + F + + I K ++ + N S+ K + FY SC+ RI ++K L + I K G E F S L+ F++ S +S + NI Q+ + ++L L K N L+ + ++ +LG S G+++ I++FE ++ L E E+ +T+ +L+ PAFDW + DL +PVV+ K ++ L +N+ + ++ NY W + M + S E+ ++ L + Y +K R CL + +L SL+ S + + N+ E + +I+ +F W+ + EK D++ I +P+ + D K + +++++ FF NM+N F+ K + L P E + T +NAYY+ +N+I P GI+Q P + + IG ++GHE++H FD G +D GNL+ +SL FK RT C V +YN Y + G G + LGENIADN L+ +Y ++K K V +NQ+FF G+A+++C+ R + + ++TD HSP K+R++G SNSK F ++C + + K C +W
Sbjct: 82 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 755
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: A0A0B2W080 (Endothelin-converting enzyme 1 OS=Toxocara canis OX=6265 GN=ECE1 PE=4 SV=1) HSP 1 Score: 197.978 bits (502), Expect = 5.928e-49 Identity = 180/739 (24.36%), Postives = 311/739 (42.08%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQ---NRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRN---------------FYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGE----------SLDENGALN-----IMKFEY---MIDKLWGE--SSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEE--HLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYS--------------SSVKNXXXXXXXXXXXXXN-----------------LTENLRLKIKSSF---------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF----TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNE-----YNLPGGLELGENIADNTALEISY---------MSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
D C+DF F CG+ + P++ N + G + Q + L N Y +CIN R+++ L + + Q ++ + + ++E S + KS P L L + ++ +T K++ I P LI L + + + +N ++ + E +++ + LN +++FE+ M E +S+ + L+ L P +W + Y + K +P+VI+ K + + VL Y +S+ R VENY KW +I L+ V + H LYFE L +F+ + R FCL P S++ S ++N ++ + L ++R ++ +F WL K ++ K+++M I YPE + D + + + + +N+ D F +M+NA +F+ + LK L + + + INA Y F+RN I +PM I + P ++ + Y+ IG IIGHE+SH FD G D GNL+D + S+R+F R+ CFV++Y+E Y + L ENI DN L+++Y SF+ G N +Q FF YA+ +C + D ++ ++HS D R+LGP NS F +A+HC + + ++KC +W
Sbjct: 85 ADACEDFFEFACGRWVRDVTPTIATPQWNVVIATGIAALRQLAKRLDELLLNTSSLKINSAEEKAISLYAACINEERLRQLGLRPWLAFVQSIGGWNPQKVFVAQPLEEILLSL--YAKSTYP---LIWLGSLVDDKNTTKHVITIDEPVPSLIYVHLYRNTSLPVTAENV-VNGNCSEFLRAIYEMSVYMAVGLLNIEPSTELNKSIAEMIEFEWRTVMAGSAMDEEKTSKQVYYSTDLQTLNEIAPFLNWSLFLNRVYETERIGKREPIVIK-KGTKWLQRLNAVLTEYQSSERGRRTVENYVKWRSILMHLQYVMLDCTKHPRGMQLYFERFLFNFALSGH-------------RNLFCLLRVTNLLPNPFASIFRKIMPEQEQKNKQLVSDIRNNVRKAFVSEVEEHDEWLEEKTKLSVLRKNKQLVSDIRNNVRKAFVSEVEEHDEWLEEKTKLSVLRKLENMESLISYPEDIYDEEAMEKEYRELMVNRTDMFWSMVNASRFSRQVGLKRLRKRVVRSSWLDNASPLTINALYNFERNIIILPMMITRPPFADFDVPMLFNYASIGSIIGHEMSHAFDVTGRQHDENGNLRDTWAQQSIRQFDVRSQCFVQQYSEFAKQGYQINASETLNENIGDNVGLKLAYKAWKSQETQASFRLPGTNFNA--DQAFFVAYAQTWCG--KNDAQRKLHLEVHSLDSLRVLGPIQNSDEFANAFHCPIGSAMNPQRKCGIW 799
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399]) HSP 1 Score: 196.438 bits (498), Expect = 5.683e-52 Identity = 184/722 (25.48%), Postives = 326/722 (45.15%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L VT+ SKI+ S R VDPC+DF ++ CG +N P S F + + + K L+ N S+ K + +Y SC+N RI+ + IAK K+ F L+ +++QP FT+ S++ ++ N+ Q+ + ++L S N+T ++ + ++ +++ +LG D+N N I+ FE + + E E+ IT+ +L+ PA +W + +L +PVV+ AK ++ +V E L +K ++ NY W LV+ S ++ FEN + K + +K R C+ + +L +L+ ++ + + + E + +I+++F W+ + EK D + I YP+ + D K + +++++FF NM+N F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D GNL+ +S+ FK RT C V++Y +Y ++ G LGENIADN L+ +Y +++ KT G VN ++Q+FF G+A+++C+ R + + ++TD HSP KYR++G SNS F ++C + + +C +W
Sbjct: 91 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVVY---AKEYLQ--QVSE--LINKTDRNLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVNATFDKHSK---------EIAEGMINEIRTAFQDALDHLNWMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 763
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399]) HSP 1 Score: 196.438 bits (498), Expect = 6.429e-52 Identity = 184/722 (25.48%), Postives = 326/722 (45.15%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L VT+ SKI+ S R VDPC+DF ++ CG +N P S F + + + K L+ N S+ K + +Y SC+N RI+ + IAK K+ F L+ +++QP FT+ S++ ++ N+ Q+ + ++L S N+T ++ + ++ +++ +LG D+N N I+ FE + + E E+ IT+ +L+ PA +W + +L +PVV+ AK ++ +V E L +K ++ NY W LV+ S ++ FEN + K + +K R C+ + +L +L+ ++ + + + E + +I+++F W+ + EK D + I YP+ + D K + +++++FF NM+N F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D GNL+ +S+ FK RT C V++Y +Y ++ G LGENIADN L+ +Y +++ KT G VN ++Q+FF G+A+++C+ R + + ++TD HSP KYR++G SNS F ++C + + +C +W
Sbjct: 93 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVVY---AKEYLQ--QVSE--LINKTDRNLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVNATFDKHSK---------EIAEGMINEIRTAFQDALDHLNWMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 765
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399]) HSP 1 Score: 196.052 bits (497), Expect = 1.072e-51 Identity = 184/722 (25.48%), Postives = 326/722 (45.15%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
SL L VT+ SKI+ S R VDPC+DF ++ CG +N P S F + + + K L+ N S+ K + +Y SC+N RI+ + IAK K+ F L+ +++QP FT+ S++ ++ N+ Q+ + ++L S N+T ++ + ++ +++ +LG D+N N I+ FE + + E E+ IT+ +L+ PA +W + +L +PVV+ AK ++ +V E L +K ++ NY W LV+ S ++ FEN + K + +K R C+ + +L +L+ ++ + + + E + +I+++F W+ + EK D + I YP+ + D K + +++++FF NM+N F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D GNL+ +S+ FK RT C V++Y +Y ++ G LGENIADN L+ +Y +++ KT G VN ++Q+FF G+A+++C+ R + + ++TD HSP KYR++G SNS F ++C + + +C +W
Sbjct: 114 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVVY---AKEYLQ--QVSE--LINKTDRNLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVNATFDKHSK---------EIAEGMINEIRTAFQDALDHLNWMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 786
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399]) HSP 1 Score: 164.081 bits (414), Expect = 2.009e-41 Identity = 90/287 (31.36%), Postives = 151/287 (52.61%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
W+ + EK D + I YP+ + D K + +++++FF NM+N F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D GNL+ +S+ FK RT C V++Y +Y ++ G LGENIADN L+ +Y +++ KT G VN ++Q+FF G+A+++C+ R + + ++TD HSP KYR++G SNS F ++C + + +C +W
Sbjct: 442 WMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 728 HSP 2 Score: 51.6026 bits (122), Expect = 4.126e-6 Identity = 70/291 (24.05%), Postives = 124/291 (42.61%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVI 885
SL L VT+ SKI+ S R VDPC+DF ++ CG +N P S F + + + K L+ N S+ K + +Y SC+N RI+ + IAK K+ F L+ +++QP FT+ S++ ++ N+ Q+ + ++L S N+T ++ + ++ +++ +LG D+N N I+ FE + + E E+ IT+ +L+ PA +W + +L +PVV+
Sbjct: 93 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVV 364
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece1 (endothelin converting enzyme 1 [Source:ZFIN;Acc:ZDB-GENE-061110-100]) HSP 1 Score: 163.31 bits (412), Expect = 2.199e-41 Identity = 175/724 (24.17%), Postives = 299/724 (41.30%), Query Frame = 1
Query: 91 LSLFLILLIVTIG-------------SKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNEN----YSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
LSL L + I+T+G +S + + R VDPC DF F CG +N P F + I K L+ +N+ K + +Y++C++ RI+ QE I + G KE FQ L + FT+ S +S ++ NI Q+ + + L L K N+ L+ L++ +LG S + + + I+ FE + + EL + +I K+L PA DW + + L +PVV+ T KV + N+ +S + NY + M+ ++ R E + E + T K P+ KL C+ + +L +L+ + + + E++ +IK +F W+ G K EK D++ I YP+ + D K + ++ + +F N+++ F+ + L P + + T +NAYY +N++ +P GI+Q P + + IG ++GHE++H FD G +D GNL+ +S+ FK +T C VE+Y+ Y+ L G LGENIADN L+ +Y K++C+ R + + ++TD HSP ++R++G SNS F ++C+ + + K+KC LW
Sbjct: 16 LSLALFICILTLGLHYNETHPGVCLSEPCVSVAAAVMGALDRSVDPCTDFYNFACGGWVKKNPLPEGKSRWGPFSNLWEQNMAIMKSLLENTNQQGLSKAELKAQRYYQACMSEARIEELGSQPL----QELINQTGGWALTGPWDKENFQEVLRIVSANYRTSPFFTVFVSTDSKNSTSNIIQVDQSGLGLPSREYYLNKTANEKYLKAYLGF----LVELGVLLGGSEETSRRMMQEIVDFETSLANITVPQEERRDEELIYHKIQAKNLSSLAPAVDWMPFLRAVFAPVSLNDSEPVVVYATEYLQ-----KVSQLITNTNKS--TLNNYMMMKVVRKMVSILDQ-RFQDAEQRFLEVMY------GTKKSCTPRWKL-------CVSDTDSALGFALGALFVKAT---------FAEDSKAFAEDMVSEIKWAFEDSLKQVGWMDGDTKKAAKEKADAIYNMIGYPKFIMDPKELDKVFNDFEVVSDLYFKNVMHYYNFSGRVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGILQAPFYSRAWPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWKNSSVEAFKRQTRCMVEQYSNYSVNNEPLNGKHTLGENIADNGGLKAAY-----------------------KVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHDFSKHFNCKADSPMNPKRKCELW 678
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: ecel1 (endothelin converting enzyme-like 1 [Source:ZFIN;Acc:ZDB-GENE-130530-692]) HSP 1 Score: 160.999 bits (406), Expect = 3.861e-42 Identity = 129/469 (27.51%), Postives = 213/469 (45.42%), Query Frame = 1
Query: 769 FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSM-LELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTGFE-INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFKK------------TGGYVNKFDNQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKY---RILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ ++ L+DL PA D I W+ + ++ + A + IK +L S R++ NY W + + L FR+ L DFS ++E + E CL AN+YF + L +L+ +Q + Q+ +++ +++ W+ KD K M I YPE + R + E ++N+ +F N++N+++FN ++ + N + + +NAYY+ NQ+ P GI+Q ++ Y IG IIGHE++HG+D G +D GNLK S KF ERT C V+ YN + N+ G L LGENIAD L+++Y +++K Y ++ Q+FF +A+ +C + R ++LTD HSP+ Y R+LG S F +HC R + + + KC +W
Sbjct: 77 YNKMKLRDLHHLAPAHD-QINWRQFLEQIFRKRISEDEEVVVLATTYIKKLS----HLLSTTPVRVLHNYMLWRVVIVLSTHLSPPFRA----------ALHDFSREVDGAEKE------VDLERLCLAQANKYFGMVLGALFVRE-HFSLHSKQRVQQMVEDIKHAFDQRLEELGWMDEKTKDAARGKFQLMMDMIGYPEFLG-RMDEVDKEYGFEVNEKSYFKNILNSIEFNINVSIHKIHQKVERNVWLLPPQTLNAYYLPTHNQMVFPAGILQPTLYDPEFPQSMNYGGIGTIIGHELTHGYDDWGGQYDRHGNLKQWWTAESYGKFLERTECVVKLYNNFTINKQNVNGKLTLGENIADMGGLKLAYHAYQKWVRENGPEPPLQGMAYTHE---QLFFVAFAQNWCMKRRPQSLYLQLLTDKHSPENYSRRRVLGSASQFDEFGRVFHCRRGSPMSPQHKCSVW 519
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: mmel1 (membrane metallo-endopeptidase-like 1 [Source:ZFIN;Acc:ZDB-GENE-101112-2]) HSP 1 Score: 159.458 bits (402), Expect = 1.187e-40 Identity = 96/293 (32.76%), Postives = 155/293 (52.90%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEK--SIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTGFEI-NAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYN--EYNLPGGLE------LGENIADNTALEI---SYMSFKKTGGY------VNKFDNQMFFFGYAKMFCN--RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
W+ + K R +K ++ I YPE + D+ I E+ + + ++F N + ++ F+ K L + NE+ +G + NA+Y NQI P GI+Q P F L+ + + IG +IGHEI HGFD G +FD GNL D S + FK+++ C +++Y +++L GG LGENIADN + +YM++ K G ++ Q+FF +A+++C RP N+ I TD+HSP K+R++G N + F AY C+ + + + KCH+W
Sbjct: 416 WMDDATKGRARDKAFAIVERIGYPEFIVDKNDPKIDEEYADLAYSTTEYFANTLASLAFDSKRRLARINTAVDKNEWISGAAVVNAFYSSSYNQIVFPAGILQPPFFGLDQAMSLNFGGIGMVIGHEIIHGFDDSGRNFDKDGNLVDWWSAESAKNFKQKSQCIIDQYGNFQWDLAGGQNLSGINTLGENIADNGGIRQAYEAYMAWVKDNGEELPLPGLHLSHQQLFFLNFAQVWCGDYRPEYASNS-IKTDVHSPGKFRVIGSLQNFEKFSEAYQCKASDAMNPRSKCHVW 707
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004622.1 (pep scaffold:Pmarinus_7.0:GL480748:697:25272:-1 gene:ENSPMAG00000004207.1 transcript:ENSPMAT00000004622.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 124.02 bits (310), Expect = 2.147e-30 Identity = 84/332 (25.30%), Postives = 160/332 (48.19%), Query Frame = 1
Query: 1132 RENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF----WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQR-NQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDS-MGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALE---ISYMSFKKTGG------YVNKFDNQMFFFGYAKMFCNRPRKDGNTRI---LTDLHSPDKYRILGPTSNSKTFESAYHC 2058
R FC+ LA++ +L +++ + + + + + +NL+ K + W+ + EK +++ + + + D + + ++ K+ + FF M+N + + ++S+L + ++A+Y ++ N + +P GI+Q P +Q KY+ IG +IGHE+ HGFD+ G ++ +G ++ T+ +FK RT C +Y+ Y + G LGENIADN L ++Y +++ G Y+N + Q FF +A+++C+ ++ I L+D HSP R+ G SNS F A+ C
Sbjct: 92 RWEFCMDLADKSLAYALGEIFA-----MKEITAKRKEDVKKMIDNLKHAFKDNLDHLPWMDNKTRLAAKEKAKNIQSAVGEDDYMEDVSNVDMFYENFKVVEGRFFETMVNFYNYTSRRTIRSMLATSMQWRAPAQTVDAFYYYESLNTMYIPAGIMQEPFYQDVYPMFLKYAGIGTVIGHELCHGFDNKAGSEYNVEGKQENWWENTTHNEFKLRTHCMEVQYSNYTWKERPINGTQTLGENIADNGGLHTALLAYARWEEQHGKEEPLPYLNLTNKQAFFVWFAQLWCSMEKESVEVEIEDALSDSHSPAAVRVRGMVSNSPAFAEAFTC 418
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000164.1 (pep scaffold:Pmarinus_7.0:GL480158:21651:32008:-1 gene:ENSPMAG00000000145.1 transcript:ENSPMAT00000000164.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 115.161 bits (287), Expect = 3.037e-28 Identity = 75/304 (24.67%), Postives = 134/304 (44.08%), Query Frame = 1
Query: 1258 TENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNE------YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLE-------LGENIADNTALEISYMSFKKTG--------------GYVNKFDNQMFFFGYAKMFCNRPRKDGNTR--ILTDLHSPDKYRILGPTSNSKTFESAYHC 2058
E++ +I+++F W+ G + EK S++ + YP+ + + F+ ++ ++ F N + + + L+ L+ P++ NAYY + N + +P + Q P+F + + KIG +IGHE++H FD G FD +G ++ SL FK+R+ C VE Y + G E L ++AD L ++ TG N D Q+FF +++++C+ + R +L D HSP + R L SNS F + ++C
Sbjct: 1 AEDIVTRIRNAFVSNLDSVAWMDGKTRAAAKEKSMSIKFQVGYPQGMLEPGFLDRLYANVTVS-GSLFENTLELYR-TRRETLQQQLSVPVDNNDNNRWSMNPQTANAYYSPEENTVVLPAALFQPPLFHGDFPMAVNFGKIGVVIGHEVTHAFDDQGRRFDGQGRMRTWWSSASLAAFKQRSDCLVELYERWAAGGVAEAFRELLGLKGDVADLGGLLTAFRVRSATGTSWWTEERGEEAFLPVRNLTDRQIFFTAFSQVWCSAETAEDRRRQLLLRDTHSPARLRTLASLSNSAEFAATFNC 302
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: mmel1 (membrane metallo-endopeptidase-like 1 [Source:ZFIN;Acc:ZDB-GENE-101112-2]) HSP 1 Score: 97.8265 bits (242), Expect = 2.821e-21 Identity = 127/593 (21.42%), Postives = 242/593 (40.81%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQNRKPSLFEE----------MTNSMFNIGKRLISQS----NENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEF----IAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQV-------YLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLD--ENGALNIMKFEYMIDKLWGESSELG-----FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTC----KVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENF--CLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKIN--KNDFFNNMINAVKFNYKNNLKSLL-NGPLNEYFTG-FEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIA 1833
+PC +F F CG K + E + + + + KRL+ ++ + + TK + Y SC++ I+ + + ++ +A T G + + + L F S+ + + + + D+ + I +P + Y + + T L + ++ +I+ + + +D + + + E I + + F ++TL L++ P ++ W ++ N LK V I++ +++ ++ + + L LNS V NY W I E++ + ++E + A+T K ++L R + C+ N P ++ +LY + + + + L E + W+ + R EK ++ + Y + + D + E+ +N ++ F N + ++F KN LK L E+ G INA+Y +NQI P GI+Q P F L + + IG +IGHEI+HGFD+ G FD +GNL D S F R+ C V +Y+ Y L G+N++
Sbjct: 12 ANPCDNFYEFACGGWPKKQVIPEDSGYYGTFHVLDDHLEIVLKRLLEEAAGSGDRDAVTKAKRLYLSCMDEEAIEERDSEPLLWLLEDVLEWPVATVDWNSTYGS--QWRLEEVLAFMTSRYGNRVIIDVGIASDVNDSKSSAIYIDQPSLGLPTRDFYFDKGYYSQVRDTYL--RAMIAVATIIRADKNITDDIDFVQEQMEGVFRLEMEIAEAITPAENRTDVTKLFNRMTLLQLQQEFPLNGFN--WTLFINEV----LKTVDIEVEASEEILVSAPEYLEQLSDILNSHPPSD-VHNYVVWILI---TEVIGSLSHKYQEAI-----------AETQKML---YGVLLARARWRHCVDYVNTALPSAVGALYVLDAF-PRHGKTKVEMMIERLREAFIHTLDEMTWMDDRTRARAREKALAITTQMGYADYIVDGNNPRLDEEYADLNYEEDVHFENTLQDLEFAVKNELKRLRRTTSKQEWDIGPATINAFYHPSKNQIVFPAGILQPPFFGLGQAMSLNFGGIGMVIGHEITHGFDNFGRKFDKEGNLVDWWTAESDEDFDSRSRCLVSQYSSYTW--DLASGQNVS 573
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO41501 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4D9]) HSP 1 Score: 179.874 bits (455), Expect = 3.422e-47 Identity = 178/700 (25.43%), Postives = 305/700 (43.57%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQ----------NRKPSLFEEMTNSMFNIGKRLISQ----SNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQ-TLGRTIK------EQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVL-GESLDENGAL---NIMKFEYMIDKLWGESSELG-----FEQITLKDLRRFCPAFDWDIIWKIYYN---VADLAKLKPVVIQMTS-----AKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSML-ELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLT-GSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNE--YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-----GGLELGENIADNTALEISYMSFKK-----------TGGYVNKFDNQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
V+PC+DF ++ CG+ N K S F ++ K++ + SN + K+R++Y SC N + I+ + K + I+ T G T EQ S + KS P F+ +F A NS +NI QI + + L +N++ +K+ + ++K A +L G + D + I +FE + +++ L + ++T++DL++ PA I W Y N + +PVV+ + + VI+T + RI+ NY W I + EL K +R E L + P K +T+ + L A + L + VK +Q ++ E + + W+ G+ EK++S+ I YP+ + D + + ++ I F N +NA +F ++ ++ + + T ++NAYY N I P GI+Q P F Y +G ++GHE++HGFDS G FD GNL+ S+ F+E SC VE+Y+ + + G L ENIADN L +++ + ++ G +++ +Q+FF G+A+++C+ K+ + +LTD HSPD+ R+ SNS+ F AY C + KKC +W
Sbjct: 56 VNPCRDFYQYACGKWLKDSVVPAGNSKWSAFHQVAEQNLRTLKKIFDRDDFASNGDIFRKVRDYYSSCTNKSIIEERDAAPLK----KLISDVGSWSVTGGHTWTAETWNFEQALSLMHKLKSTPLFY-MFVAADDKNS---SQNIIQIQQAGITLSDREYYTRNESDKVVKKY--KEFMVKIATLLNGATADSTTGILMDEIFQFEKKLAEIYEPKERLRHSDKIYHKMTVEDLQQLAPA----IPWMDYMNNLFSTPVGHDEPVVVYTPTFLKSMSDLVIRTDR------------RILANYMVWHLIKPLTTELSKPYR---------EAALDLMRVEMGVESGAPTWKSCVTKTDTVLGYATGH--LYVKQHDGKDVKEKAKQVIQ------SIKEAFISNLPTVTWMDEGTKTKARGEKMESVLDLIGYPDWIMDVAQLNAYYVNLVITPEMSFENHLNARRFVHQQTMEKRGKAVDRKEWHMTPVDVNAYYSLPNNYIAFPSGILQRPFFDPEFPQAMNYGAVGMVMGHELTHGFDSKGRLFDKNGNLESWWKNQSVEAFEEHVSCMVEQYSNFTVADVKVDGKQTLDENIADNGGLRLAFQAHRQWDKENEKQPRLPGLELSR--DQLFFLGFAQLWCSSSTKNSMHHPLLTDSHSPDRIRVHAAVSNSEQFAEAYDCPLDTPMNPAKKCRVW 710
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO35107 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMH5]) HSP 1 Score: 151.369 bits (381), Expect = 6.388e-38 Identity = 89/291 (30.58%), Postives = 151/291 (51.89%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSF------------KKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTD-LHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
W+ + EK +++R NI YP+ + ++ + + ++++K +F N KF + N+ L P+++ +NAYY N+I P GI+Q P ++ + N Y IG ++GHEI+HGFD G F+ GNL S+ FK++T C V++Y+ Y G GL+ LGENIADN ++ S+ ++ K+ G +Q+FF +A+++C+ R + R + + +HSP K R++G SNS F A+ C +++ K KC +W
Sbjct: 383 WMDEKTRKVAKEKAEAIRENIGYPDFIKNKTALELEYSGVRVDKTKYFWNQYERRKFYNQKNIDEL-GKPVDKTKWSMNPPTVNAYYSSTDNKIVFPAGILQDPFYEGDHPNSLNYGGIGMVVGHEITHGFDDNGRKFNKDGNLLTWWTNNSIEAFKKKTDCLVKQYSSYEFHGKKLNGLQTLGENIADNGGIKQSFQAYQKWKKDNNVEEEKRLPGLEKLSHDQLFFLSFAQIWCSAYRPEAAIRAIENGVHSPGKLRVIGSLSNSNEFAEAWKCPVGSRMNPKDKCAVW 672
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO49684 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFZ0]) HSP 1 Score: 150.214 bits (378), Expect = 1.342e-37 Identity = 176/703 (25.04%), Postives = 303/703 (43.10%), Query Frame = 1
Query: 187 PCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSN------ENYS-TKLRNFYKSCINLNRIKR----------KSLNSF-----KYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLL---KEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-IMKFEYMIDKLWGESSELG---FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNS--KESFR-IVENYFKWTTIFSMLELV-KTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHE-KSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE--INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNL-KDLLGKTSLRKFKERTSCFVEKY------NEYNLPGGLELGENIADNTALEISYMSF----KKTGGYVN-----KFDN-QMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
PCKDF +F CG + P S F +++ + + + L+ + EN + K ++FY+SC++ I+R + L S+ K W +E Y + L Q ++ + P F++ + + ++ +++ ++ + + L + + E T +E + K A +LG + + I+ FE + + + + + +I L L + P F W + + A +T A V+ T +N KE+ + ++ NY W I + L+ K FR + F + ++ K++EP R C + N + L +LY N + + I + + + ++K W+ + +K D++R I Y V R IL KS+KI K FF+N +N K+ + L E + F INA Y F N+I G ++ L ++ Y +G IIGHE++HGFD+ G FD G++ ++ K+SL FK R C ++Y N+Y L G + L ENIADN ++SY ++ K G K+ N Q+FF GYA+ +C+ R K L+D+HSP K+R++G SN + F A+ C + + KKKC +W
Sbjct: 24 PCKDFFKFSCGNWVRKHPIPRSYNDFSTFTKVSKDIEDQLRELLETPSYIETLPENQALRKAKDFYRSCMDTKTIERLGTRPLMKLIRQLGSWSLCNDKSWNKEKWDAYDVLRKL----------QSTYYPASP----FFSVEVTNDHLNSTRHLIKVDQSGLSLQREIYFKHPEMVDTYVEY--------MAKVATLLGIKGNATKEMRKIVDFETKLANITTSAEDKADGIYRRIKLHHLIKLVPGFPWLKHMQAIFRGA----------HVTDADVVLATPSTYLSKMNDIIKETPKELLSNYVVWQMIRDKISLLSKPFR---KARAVFNHKISG------VKEQEP-------RWRTCTSITNDNLGVPLGTLYVRKYFNESTVGKIQLMIQ-EIKDTFKERVKEHEWIDDKTTQYVFQKADALRSKIGYANYVL-RPIILKKRFKSLKIGKKTFFSNNVNVDKWVRHRLVGKLRKAVDKEKWPMFPQTINAMYQFYENEIGGGRGCLRRVFLALALALSLSYGAVGSIIGHEMTHGFDNTGRKFDKNGDIVQEWWSKSSLTNFKNRAQCIADQYSKFKIQNKYPLSGVVTLDENIADNGGTKLSYNAYHRWLKDNGNQEQVLPGLKYTNEQLFFIGYAQEYCSHARPKTEYIASLSDIHSPPKFRVIGTLSNMEEFSDAFKCPPGSPMNPKKKCEVW 676
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO31998 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWD9]) HSP 1 Score: 139.043 bits (349), Expect = 5.643e-36 Identity = 86/288 (29.86%), Postives = 145/288 (50.35%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSF------------KKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTD-LHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
W+ + EK +++R NI YP+ + ++ + + +++ F + N + N + +N P +NAYY N+I P GI+Q P ++ + N Y IG ++GHEI+HGFD G F+ GNL S+ FK++T C V++Y+ Y G GL+ LGENIADN ++ S+ ++ K+ G +Q+FF +A+++C+ R + R + + +HSP K R++G SNS F A+ C +++ K KC +W
Sbjct: 63 WMDEKTRKVAKEKAEAIRENIGYPDFIKNKTALELEYSGVRVVYTYFRQHSENLLSVIV--NFRWSMNPPT--------VNAYYSSTDNKIVFPAGILQDPFYEGDHPNSLNYGGIGMVVGHEITHGFDDNGRKFNKDGNLLTWWTNNSIEAFKKKTDCLVKQYSSYEFHGKKLNGLQTLGENIADNGGIKQSFQAYQKWKKDNNVEEEKRLPGLEKLSHDQLFFLSFAQIWCSAYRPEAAIRAIENGVHSPGKLRVIGSLSNSNEFAEAWKCPVGSRMNPKDKCAVW 340
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO37487 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFL4]) HSP 1 Score: 137.502 bits (345), Expect = 1.064e-34 Identity = 88/293 (30.03%), Postives = 146/293 (49.83%), Query Frame = 1
Query: 1279 IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK------KTGGYVNKFD---NQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ S W+ G+ K++ EK ++ +I YP+ + D + +++ + F N ++ +KF + +L + L P+N ++N YY ++N+I GI+Q P F Y +G +IGHEI+HGFD G FD GNL + + F +T C V +YN Y NL G L ENIADN ++++Y +K G + +Q+F+ G+A+ +C+ + +I TD HS KYR++GP N F + C++ +K+ KKC +W
Sbjct: 135 VDSLPWMDGATKEKAKEKAIAIHESIGYPDYIKDPAKLEAKIQNLTFG-DRLFENTLSLIKFTVQTDL-AQLKKPVNREKWELGPSQVNGYYNSRQNRIVFLAGILQPPFFNPLYPKYLNYGGLGMVIGHEITHGFDGSGRMFDKDGNLNNWWSSEASMNFNSKTQCLVHQYNTYSAFGKNLNGSQTLNENIADNGGIKMAYEGYKAWARENSAEGALPGLGLSVDQLFYVGFARPWCSIYTEQTAILQINTDSHSYPKYRVIGPLQNDPLFSEVFKCKKNSKMNPAKKCAVW 425
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:101164289]) HSP 1 Score: 187.193 bits (474), Expect = 7.190e-49 Identity = 177/723 (24.48%), Postives = 318/723 (43.98%), Query Frame = 1
Query: 94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL----NIMKFEYMIDKL-----WGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
L L +T+ S+I+ ++ R VDPC+DF +F CG +N P S F + + K L+ N S+ K +++Y SC+N RI+ + I K G K+ F L+ +++QP F++ S + ++ N+ Q+ + ++L S N+T E +++ +LG +++ L I++FE + + E + ++T+ +L+ PA DW + +L +PVV+ A+ ++ +V E L +K ++ NY WT + S+ L + F + + L S T K P R C+ + +L +L+ + + + + E + +I+S+F W+ + EK DS+ I +PE + D K + +++ + FF NM+N F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D +GNL+ +S+ F+ RT C +E+YN Y ++ G LGENIADN L+ +Y +++ K VN ++Q+FF G+A+++C+ R + + ++TD HSP +YR++G +NS F + C + K C +W
Sbjct: 90 GLCLSEACITVASQIV-------EAMDRSVDPCQDFYQFACGGWMRKNPLPDGRSRWSTFNSIWGQNQALLKHLLENGTFNGSSEAERKTQSYYLSCLNTQRIEELGAQPLI----DLITKIGGWNMTGPWDKDNFMEVLKVVSGPYRAQP----FFSVGVSADPKNSNSNVVQVDQSGLFL-PSRDYYLNKTANEKVLAAYLDYMVELGMLLGG--EKSSTLVQMQQILEFETALANITVPQDQRRDEEKIYHKVTIAELQALAPAVDWLEFLTSSLSPLELNDTEPVVLY---AREYLQ--QVSE--LINKTDRSLLNNYMMWTLVQKSVATLDQRFENAQDRLLE--------SLYGTKKSCTP-------RWQTCIGNTDDTLGFALGALFVKATFDKLSK---------EIAEEMINEIRSAFKQALDRLSWMDEQTRKAAKEKADSIYDMIGFPEFILDPKELDDVYDGYEVSDDSFFQNMLNFYNFSARVMADQLRKTPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAHDHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNSSVEAFRVRTECMMEQYNRYTVNGEHVNGKQTLGENIADNGGLKAAYHAYQSWIQRNGQEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPRYRVIGTLANSPDFSRHFGCPEGTPMNSGKPCEVW 763
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: ecel1 (endothelin converting enzyme like 1 [Source:NCBI gene;Acc:101160572]) HSP 1 Score: 171.4 bits (433), Expect = 1.285e-43 Identity = 162/699 (23.18%), Postives = 315/699 (45.06%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQNRKPSLFEEMTNS---MFNIG-------KRLI-----SQSNENYSTKLRNFYKSCINLNRIKR-------KSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF-FKSQPPFHQ--LFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLI-KWANVLGESLDENGALNIMKFEYMIDKLWGESSE-------LGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTS----AKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLN--GPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ PC+DF F CG K E S + IG +RL+ +S + K++ FY+SC+N+ RI + + L+S W + + + Q E +++Q + F+L +++ ++ +N +I + + L + L Q + +K + K L+ + ++LG + I++ E + + E + +ITL++L+ P W ++ KI+++ + ++ + +V+ T ++I+T S R++ NY W + ++ E + T F + + +FS +++ L L+R CL N++F ++L +L+ Q + + ++ +++ +L L++ W+ + K K+ M + YP+ + + I E +N+ +F N++N++KFN K ++K + +NAYY+ +NQ+ P GI+Q ++ Y IG IIGHE++HG+D G +D GNLK + S RKF+++ C V+ Y+ + + G L LGENIAD L+++Y +++K +V + Q+ F +A+ +C + R ++LTD H+P+ YR++G S F +HC + + + KC +W
Sbjct: 137 IQPCQDFYSFACGGWLKRHGIPEDKLSYGIITAIGEHNEEKLQRLLLEPIRRRSPNSAERKVKEFYRSCVNIQRIDKLGSEPMTELLDSCGGW--DLVGAPPSAAGWVQEGAPQMPDFDELLYRTQGVYSTAVFFSLTVNVDDKNSSRNAIRIDQEGLTLPERSLY-LGQDEDSVKILAAYKALMERLLSMLGAHNATQKSKEIIQLETRLANITVSEYEDQRKDISTMYNRITLRELQHIAPNLRWKHLLDKIFHD--NFSEDEEIVVLATDYIKKVSNIIRTT-----------SKRVLHNYMLWRIVAALSEHLSTA---------FRSTIHEFSREIDGTEQQ----LELSR--LCLTQTNKHFGMALGALFVQQ-HFSSQSKAKVQELVEDIKHSLDLRLHELDWMDEATKQAARAKLKHMMVMTGYPDFLVKPELI-DQEYGFDVNEKTYFKNILNSIKFNIKLSVKKIHEEVDKTAWLLPPQALNAYYLPNKNQMVFPAGILQPTLYNPEFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRHGNLKQWWTEESYRKFQKKAECIVKLYDNFTVYNQRVNGRLTLGENIADMGGLKLAYSAYQK---WVREHGPERPLPGLKYTHEQLLFIAFAQNWCMKRRSQSIYLQLLTDKHAPEHYRVIGSVSQFDEFSRVFHCPKDSPMNPASKCSVW 799
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: phex (phosphate regulating endopeptidase homolog X-linked [Source:NCBI gene;Acc:101156288]) HSP 1 Score: 165.622 bits (418), Expect = 5.251e-42 Identity = 134/496 (27.02%), Postives = 223/496 (44.96%), Query Frame = 1
Query: 718 KFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVAD-----LAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKI-----KSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTG-FEINAYYIFQRNQINVPMGIIQGPIF-QLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-------NLPGGLELGENIADNTALEISYMSFKK-----TGGY-------VNKFDNQMFFFGYAKMFCNRPRKD-GNTRILTDLHSPDKYRILGPTSNSKTFESAYHC-ERXXXXXXXXXCHLW 2103
K +M+ +SE + + TL L+R P FDW K D L+ +PV+++ + + L LN+ E R + NY +W T+FS + T S + Y + YA+ T + R + C+ + L+ +S Q+ Q+ + L E +R K + W+ K + VEK ++ + YPE + + ++ K + ++ D++ N++ +KF + ++ L P E+FT +NA+Y NQI P G +Q P F Y IG I+GHE++HGFD+ G +D GNL +S+ F E+T C +++YN Y N+ G L ENIADN + ++ ++++ GG V+ +NQ+FF YA + CN R + +I HSP KYR++G SN + F+ A+ C E + + C +W
Sbjct: 251 KLAHMLIPHENRTSENMYNKFTLSRLQRSLPQFDWMGFVKAVVESRDDPDRDLSSSEPVIVRAP------QYFRELMKLLNTTEP-RTIANYVQWRTVFSRI----TTLSRRFLYRYLD-------YARVTT----GTTSLTPRWDKCVNYVENALGYATGRLFVNSY-----FQEDKKQMMEELIEGIRWAFIDMLQKENGWMDEPTKKKAVEKAHAVMAKVGYPEFILNDTYLNEDLKELDFSEKDYYGNVMQTLKFFAQGDISWLRRSVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFWGQEFPRSLSYGAIGVIVGHELTHGFDNNGRKYDKNGNLDQWWSNSSVTAFTEKTQCMIDQYNSYHWEEAGLNVRGKRTLAENIADNGGIREAFRAYRRWVDDNRGGVEEPLLPGVDFSNNQLFFLSYAHVRCNSYRPEAAREQIQNGAHSPPKYRVIGAMSNYEEFQKAFRCPESSVMNRGSQSCRVW 719
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:101164289]) HSP 1 Score: 165.622 bits (418), Expect = 9.857e-42 Identity = 123/471 (26.11%), Postives = 218/471 (46.28%), Query Frame = 1
Query: 769 FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
+ ++T+ +L+ PA DW + +L +PVV+ A+ ++ +V E L +K ++ NY WT + S+ L + F + + L S T K P R C+ + +L +L+ + + + + E + +I+S+F W+ + EK DS+ I +PE + D K + +++ + FF NM+N F+ + L P + + T +NAYY+ +N I P GI+Q P + + + IG ++GHE++H FD G +D +GNL+ +S+ F+ RT C +E+YN Y ++ G LGENIADN L+ +Y +++ K VN ++Q+FF G+A+++C+ R + + ++TD HSP +YR++G +NS F + C + K C +W
Sbjct: 350 YHKVTIAELQALAPAVDWLEFLTSSLSPLELNDTEPVVLY---AREYLQ--QVSE--LINKTDRSLLNNYMMWTLVQKSVATLDQRFENAQDRLLE--------SLYGTKKSCTP-------RWQTCIGNTDDTLGFALGALFVKATFDKLSK---------EIAEEMINEIRSAFKQALDRLSWMDEQTRKAAKEKADSIYDMIGFPEFILDPKELDDVYDGYEVSDDSFFQNMLNFYNFSARVMADQLRKTPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAHDHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNSSVEAFRVRTECMMEQYNRYTVNGEHVNGKQTLGENIADNGGLKAAYHAYQSWIQRNGQEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPRYRVIGTLANSPDFSRHFGCPEGTPMNSGKPCEVW 789
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: MME (membrane metalloendopeptidase [Source:NCBI gene;Acc:101170860]) HSP 1 Score: 155.606 bits (392), Expect = 5.993e-39 Identity = 92/291 (31.62%), Postives = 151/291 (51.89%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSL-LNGPLNEYFTGFEI-NAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKY--------NEYNLPGGLELGENIADNTALEISYMSFK---KTGGY------VNKFDNQMFFFGYAKMFC--NRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
W+ K EK ++R I Y + + D + + K + N +F N++ +++ K L+ L + +E+ TG + NA+Y +NQI P GI+Q P F + Y IG +IGHEI+HGFD G ++D G+LKD S R+F E+++C V++Y N +L G LGENIADN + +Y +++ K G ++ +Q+FF +A+++C +RP + N+ I D+HSP K+R+LG N F A+ C + + + C +W
Sbjct: 354 WMDAETKKAAEEKARAIRERIGYSDTIMDDEHLNNEYKDLSYNAEKYFENILQNLEYVQKKRLRKLRVKVNKDEWVTGAAVVNAFYSASKNQIVFPAGILQPPFFSKGQAKSLNYGGIGMVIGHEITHGFDDNGRNYDKDGDLKDWWTPDSTRRFLEQSNCIVDQYSNFSWELANGLHLNGNNTLGENIADNGGIRQAYQAYRNHVKDHGEEPPLPGIDLSHDQLFFLNFAQVWCGTHRPEQAVNS-IKVDVHSPGKFRVLGSLQNFPEFAKAFSCNKSSYMIPDNVCRVW 643
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000069765.1 (SMESG000069765.1) HSP 1 Score: 1340.1 bits (3467), Expect = 0.000e+0 Identity = 679/679 (100.00%), Postives = 679/679 (100.00%), Query Frame = 1
Query: 67 MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNIPQQQQGIIQIFQNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERKNKIKEKKKCHLW
Sbjct: 1 MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNIPQQQQGIIQIFQNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERKNKIKEKKKCHLW 679
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000025056.1 (SMESG000025056.1) HSP 1 Score: 195.667 bits (496), Expect = 7.519e-52 Identity = 176/696 (25.29%), Postives = 318/696 (45.69%), Query Frame = 1
Query: 181 VDPCKDFNRFVCGQ----------NRKPSLFEEMTNSMFNIGKRLIS----QSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTI-----KEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL------------NIMKFEYMIDKLWGE-----SSELGFEQITLKDLR-RFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENF--CLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF-TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
V+PC DF++FVCG+ + + S F+ + +F I K+L+ ++N + +K Y SC+NL+RI + Y + L + K +E + P ++ NS + N+ Q+S +L+ +N+TK E K+IL +V + + + G L I+K E I K + + E + ++TL +++ ++C F+W I + + ++ K + I +T+ +++ C++ + Y + K RI+ NY W T++ + + DF K K R ++ T+E + C+ + + L L ++Y + N + Q + I L + + + S+ W+ + +EKID+M I Y + + + ++ K I+IN +F N+ N + L P N T E+NA+Y +N+I P GI+Q P F+ KY IG +GHEI HGFD G +DSKG+L+ + + FK ++ CFV++Y++Y++ G LGENIADN + ++Y +K K +N +Q+FF +A+++CN + ++ IL++ H+P+ YR++G SN K F A++C + + + KC +W
Sbjct: 115 VNPCYDFSQFVCGKWQSEQILPKGSSRYSTFDVVNTDLFKIQKKLLENPEFKTNSDIYSKAVKLYDSCLNLDRINSLGAIPLVTYLNRTFGAYGGWEMLTNDLNPTLDKWDLAKVIEDPMVETPIIRIIVQEDEKNSSRNILNL-QLS----WLLMERQFLQNETKPENKKIL---------DVFKDYMYDVGKLLKIRKEKFEQFNEILKLEIEIAKKYPKEEDQRDPESTYNKMTLSEIQGKYCQQFNWTEIVRRRMKLVNITMSKDIEIIVTNPTNLLDICELFKSYASKK---RILHNYVLWRTVYQRINFLSE----------------DFQRIKD-KFRRVYYGVVGTKERWEHCVSIVQVHMSLILGNMYIKNNFNKQSKPQVLEMINL-LKQKFQNNLLSNVWMDDQTRSHALEKIDTMWPLIGYTDSILNVTYLEETFKDIEINDQTYFENIDMLTNRAMYRNFEKLNKRPENSTIDTPQEVNAFYSPNKNEIIFPAGILQNPFFEPGFPRSLKYGGIGTAMGHEIIHGFDDTGSKYDSKGDLRVWWTDRTRQLFKTKSDCFVKQYSKYSIHGHSINGENTLGENIADNGGVRLTYQVYKDLEKKYGKEKLLPGLNYTHDQLFFITFARLWCNLQTKQSIIIDILSNAHTPNHYRVIGTLSNFKEFAEAFNCPKGSGMNPTDKCMVW 775
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000025056.1 (SMESG000025056.1) HSP 1 Score: 191.815 bits (486), Expect = 6.221e-50 Identity = 178/707 (25.18%), Postives = 322/707 (45.54%), Query Frame = 1
Query: 139 LSSSKKDGKSNQRFVDPCKDFNRFVCGQ----------NRKPSLFEEMTNSMFNIGKRLIS----QSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTI-----KEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL------------NIMKFEYMIDKLWGE-----SSELGFEQITLKDLR-RFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENF--CLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF-TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXC 2094
L ++ + KS V+PC DF++FVCG+ + + S F+ + +F I K+L+ ++N + +K Y SC+NL+RI + Y + L + K +E + P ++ NS + N+ Q+S +L+ +N+TK E K+IL +V + + + G L I+K E I K + + E + ++TL +++ ++C F+W I + + ++ K + I +T+ +++ C++ + Y + K RI+ NY W T++ + + DF K K R ++ T+E + C+ + + L L ++Y + N + Q + I L + + + S+ W+ + +EKID+M I Y + + + ++ K I+IN +F N+ N + L P N T E+NA+Y +N+I P GI+Q P F+ KY IG +GHEI HGFD G +DSKG+L+ + + FK ++ CFV++Y++Y++ G LGENIADN + ++Y +K K +N +Q+FF +A+++CN + ++ IL++ H+P+ YR++G SN K F A++C + + + KC
Sbjct: 101 LQAAVEIRKSLNTSVNPCYDFSQFVCGKWQSEQILPKGSSRYSTFDVVNTDLFKIQKKLLENPEFKTNSDIYSKAVKLYDSCLNLDRINSLGAIPLVTYLNRTFGAYGGWEMLTNDLNPTLDKWDLAKVIEDPMVETPIIRIIVQEDEKNSSRNILNL-QLS----WLLMERQFLQNETKPENKKIL---------DVFKDYMYDVGKLLKIRKEKFEQFNEILKLEIEIAKKYPKEEDQRDPESTYNKMTLSEIQGKYCQQFNWTEIVRRRMKLVNITMSKDIEIIVTNPTNLLDICELFKSYASKK---RILHNYVLWRTVYQRINFLSE----------------DFQRIKD-KFRRVYYGVVGTKERWEHCVSIVQVHMSLILGNMYIKNNFNKQSKPQVLEMINL-LKQKFQNNLLSNVWMDDQTRSHALEKIDTMWPLIGYTDSILNVTYLEETFKDIEINDQTYFENIDMLTNRAMYRNFEKLNKRPENSTIDTPQEVNAFYSPNKNEIIFPAGILQNPFFEPGFPRSLKYGGIGTAMGHEIIHGFDDTGSKYDSKGDLRVWWTDRTRQLFKTKSDCFVKQYSKYSIHGHSINGENTLGENIADNGGVRLTYQVYKDLEKKYGKEKLLPGLNYTHDQLFFITFARLWCNLQTKQSIIIDILSNAHTPNHYRVIGTLSNFKEFAEAFNCPKGSGMNPTDKC 772
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000001289.1 (SMESG000001289.1) HSP 1 Score: 166.777 bits (421), Expect = 1.515e-47 Identity = 90/133 (67.67%), Postives = 106/133 (79.70%), Query Frame = 1
Query: 2284 IWRKNLIFIITEMEPLQILQTELAHARKTSENFYDQIVKLSREIQQTKATWVEPRKAKRIYQRLTAAQKVWMEEKQLNQSLKVQIKGLEVALAASQEKTAVTYPLVFTPAQLAYRXXXXXXXXXXXXSSHRPG 2682
I LIF++T+ME L+I Q EL HARKT++NFY+QI++LS EIQ TK W+EPRK K +YQ LTAAQK W +EKQLNQSL++QIKGLEVAL+A QE AVTY LVF PAQLAYRE ATP TP TSS+RPG
Sbjct: 5 IGSPELIFVVTQMESLKIPQKELDHARKTNKNFYEQIIQLSTEIQPTKTAWMEPRKTKALYQMLTAAQKGWADEKQLNQSLRMQIKGLEVALSACQEGAAVTYTLVFAPAQLAYRETVATPKTTPATSSYRPG 137
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000019730.1 (SMESG000019730.1) HSP 1 Score: 164.466 bits (415), Expect = 3.308e-47 Identity = 92/120 (76.67%), Postives = 104/120 (86.67%), Query Frame = 1
Query: 2320 MEPLQILQTELAHARKTSENFYDQIVKLSREIQQTKATWVEPRKAKRIYQRLTAAQKVWMEEKQLNQSLKVQIKGLEVALAASQEKTAVTYPLVFTPAQLAYRXXXXXXXXXXXXSSHRP 2679
ME +ILQ EL HA+ ++ FY+QI++LS+E+QQTKATWVEPRKAKRI+QRLTAAQK WMEEK+ N+SLKVQIK LEVALAASQE TAVTYPLVF PAQLAYRE AAT T TP TSSHRP
Sbjct: 1 MESQRILQKELEHAKAVNKVFYEQILQLSKEVQQTKATWVEPRKAKRIFQRLTAAQKGWMEEKKQNRSLKVQIKELEVALAASQEGTAVTYPLVFAPAQLAYRETAATLTTTPATSSHRP 120 The following BLAST results are available for this feature:
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30002040 ID=SMED30002040|Name=Endothelin converting enzyme 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2849bpback to top protein sequence of SMED30002040-orf-1 >SMED30002040-orf-1 ID=SMED30002040-orf-1|Name=SMED30002040-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=680bp MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCback to top protein sequence of SMED30002040-orf-2 >SMED30002040-orf-2 ID=SMED30002040-orf-2|Name=SMED30002040-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=162bp MEPLQILQTELAHARKTSENFYDQIVKLSREIQQTKATWVEPRKAKRIYQback to top Annotated Terms
The following terms have been associated with this transcript:
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