Endothelin converting enzyme 2

Overview
NameEndothelin converting enzyme 2
Smed IDSMED30002040
Length (bp)2849
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Endothelin converting enzyme 2 (SMED30002040) t-SNE clustered cells

Violin plots show distribution of expression levels for Endothelin converting enzyme 2 (SMED30002040) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Endothelin converting enzyme 2 (SMED30002040) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Endothelin converting enzyme 2 (SMED30002040) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30002040

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30002040SMESG000069765.1 SMESG000070035.1 dd_Smed_v4_5256_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30002040SMESG000069765.1 SMESG000070035.1 dd_Smed_v4_5256_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002040SMESG000069765.1 Contig46618newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002040SMESG000069765.1 Contig46618uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002040SMESG000069765.1 Contig44069newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30002040SMESG000069765.1 Contig44069uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
protonephridiaSMED30002040SMESG000069765.1 SMESG000070035.1 dd_Smed_v6_5256_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275])

HSP 1 Score: 178.333 bits (451), Expect = 7.208e-46
Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S  L    + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K + FY SC+ + RI+       +    + I K       G   ++ F   L+           FT+  S +S  +  N+ Q+ +  ++L      +     EK  T     +E   +L+  +       + + L+    L I      + +      E  + ++++ +L+   P+ DW        +  +L+  +PVV+        +   + +   +N  E   I+ NY  W  +  +   L + F S  E+       L +  Y          +K  + R   C+   +     +L SL+  +  +   +          + E +  +I+++F        W+    +    EK D++   I +P+ + + K +       +I+++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+YN+Y      L G   LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:   63 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275])

HSP 1 Score: 178.718 bits (452), Expect = 9.080e-46
Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S  L    + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K + FY SC+ + RI+       +    + I K       G   ++ F   L+           FT+  S +S  +  N+ Q+ +  ++L      +     EK  T     +E   +L+  +       + + L+    L I      + +      E  + ++++ +L+   P+ DW        +  +L+  +PVV+        +   + +   +N  E   I+ NY  W  +  +   L + F S  E+       L +  Y          +K  + R   C+   +     +L SL+  +  +   +          + E +  +I+++F        W+    +    EK D++   I +P+ + + K +       +I+++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+YN+Y      L G   LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:   92 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 765          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275])

HSP 1 Score: 178.333 bits (451), Expect = 1.363e-45
Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S  L    + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K + FY SC+ + RI+       +    + I K       G   ++ F   L+           FT+  S +S  +  N+ Q+ +  ++L      +     EK  T     +E   +L+  +       + + L+    L I      + +      E  + ++++ +L+   P+ DW        +  +L+  +PVV+        +   + +   +N  E   I+ NY  W  +  +   L + F S  E+       L +  Y          +K  + R   C+   +     +L SL+  +  +   +          + E +  +I+++F        W+    +    EK D++   I +P+ + + K +       +I+++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+YN+Y      L G   LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:  138 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECE2 (endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275])

HSP 1 Score: 178.718 bits (452), Expect = 1.939e-45
Identity = 170/720 (23.61%), Postives = 306/720 (42.50%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S  L    + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K + FY SC+ + RI+       +    + I K       G   ++ F   L+           FT+  S +S  +  N+ Q+ +  ++L      +     EK  T     +E   +L+  +       + + L+    L I      + +      E  + ++++ +L+   P+ DW        +  +L+  +PVV+        +   + +   +N  E   I+ NY  W  +  +   L + F S  E+       L +  Y          +K  + R   C+   +     +L SL+  +  +   +          + E +  +I+++F        W+    +    EK D++   I +P+ + + K +       +I+++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+YN+Y      L G   LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:  210 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR----DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLE----LEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYG------MDYLQQVSELINRTEP-SILNNYLIWNLVQKTTSSLDRRFESAQEK-------LLETLYGT--------KKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Match: ECEL1 (endothelin converting enzyme like 1 [Source:HGNC Symbol;Acc:HGNC:3147])

HSP 1 Score: 167.933 bits (424), Expect = 3.139e-42
Identity = 156/697 (22.38%), Postives = 305/697 (43.76%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQ--NRKPSLFEEMT-NSMFNIG-------KRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEF----IAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQ--LFTLATSINSFDTVKNIPQISRPQVYLIQSLL----KEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMI--------DKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFR-SHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRL----KIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            +DPC+DF  F CG    R     +++T  ++  IG       +RL+++           K+R F++SC+++  I+R          ++     +   +ER      +  ++      +K+Q  +    LF+L  S++  ++ + + +I +  + L +  L     E ++  L   R+ + + L    ++LG    E  A  I++ E  +        D L  + S + + ++TL  L++  P   W  +    +   D ++ + VV+  T     +         L      R++ NY  W  +  + E L   FR + HE     E          + K +E  R         CL  AN++F ++L +L+                  Q L E+++     +++   W+    +     K+  M + + YP+ +  +   +  E   ++++  +F N++N+++F+ + ++K +             +NAYY+  +NQ+  P GI+Q  ++  +      Y  IG IIGHE++HG+D  G  +D  GNL     + S  +F  +  C V  Y+ +      + G   LGENIAD   L+++Y +++K   +V +              +Q+FF  +A+ +C + R      ++LTD H+P+ YR+LG  S  + F  A+HC + + +    KC +W
Sbjct:  120 IDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPG----VAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVL----SLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSM-YNKVTLGQLQKITPHLRWKWLLDQIFQ-EDFSEEEEVVLLATDYMQQVSQ-------LIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEG---------SDKPQELAR--------VCLGQANRHFGMALGALFVHE-----HFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLL-KPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQK---WVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 773          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-2 (Neprilysin-2 [Source:UniProtKB/Swiss-Prot;Acc:O44857])

HSP 1 Score: 172.555 bits (436), Expect = 2.265e-44
Identity = 167/694 (24.06%), Postives = 313/694 (45.10%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQ--------NRKPSL--FEEMTNSMFNIGKRLISQSNENYS------TKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPF--HQLFTLATSINSFDTVKNIPQISRPQVYLIQS--LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEY------MIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVI----KTCKVLEYYLNSKESFRIVENYFKWTTIFSML--ELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNX--XXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE--INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            VDPC DF  F CGQ        +  PS+  FE +   +    K L+ +++E Y        K + FY  C+N + I    L++++  + E +  +    +LG  +K     ++ +      F    LF      +  ++ +++  I +PQ+ L      +  +N+ ++   +++ +  ++  A+    +LD   A  I+ FE       M D+   + +EL + +ITL ++RR  P F+W + +   +   DL +     I       V+    +  + L+  +   ++ R++ NY +W   F  +  +L   F             LT F + KT      ++     R + C+   N   P++ +++Y   VKN    + +Q + ++   + E+    + S  WLT   K    +K++ M+  I YP+ + D   +    K+ K+    ++    +  +   ++ L+ +      E +      +NA+Y    N+I  P GI+Q   +  +  +   +  IG +IGHEI+HGFD  G  +D+ GN++      ++ KF+ +  C  ++Y+ Y L        G    GENIADN  L+ +Y ++KK             VN   +Q+FF  YA+++C     K+   ++ T  HSP   R+ GP SNS  F  AY+CE  +++  ++KC +W
Sbjct:   73 VDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETSAVGKAKYFYNLCLNESEI----LDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTRATLD---AKEIIDFETALANITMADEHRHDIAEL-YTKITLGEMRRSLPHFNWPLFFNRMFK--DLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDN-RLIVNYLEWCWFFKTMLRDLPDPF------------ALTIFKFYKTLNIMNVQK----VRWHGCVTRINSLMPMATSAIY---VKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-11 (Neprilysin-11 [Source:UniProtKB/Swiss-Prot;Acc:O16796])

HSP 1 Score: 160.229 bits (404), Expect = 5.127e-40
Identity = 103/371 (27.76%), Postives = 173/371 (46.63%), Query Frame = 1
Query: 1054 FENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKK----------TGGYVNKFDNQMFFFGYAKMFCNRPRKDGN-TRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            FE+I  DF    T +Q+ P R         C Q+ +   PL+  ++Y  +       +   +++  +L  +    ++ + W+    K   +EK +SM  NI YP+V  D   +      + I+ +D +  ++       ++     L  P +++    +   +NA+Y  ++N I  P GI+Q P F         Y  IG +IGHEI+HGFD  G  +D  GNL +   ++SL  F  R  C VE+Y  Y +P       G L  GENIADN  ++ ++ +++K            G     + Q+FF  YA  +C + ++     ++LTD HSP+ +R++G  SN + F   Y C R   +    KC +W
Sbjct:  485 FEDIKQDFLKVMTGQQQSPPRW------KDCAQVPSTVLPLAAGAIYVQA-HFQESDKHEALRMIMHLRNSFADLVRQNDWMDEETKAVAIEKANSMINNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYIMKKSVVWMQSREFQKLTKPFDKHEFDISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFPKAVNYGAIGAVIGHEITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKTNFRVNGKLTQGENIADNGGVKEAFQAYQKYVTENGEEPRLPGLQQYTNEQIFFVSYAHFWCGKKKEAAAMQQVLTDEHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-1 (Neprilysin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q18673])

HSP 1 Score: 155.606 bits (392), Expect = 9.614e-39
Identity = 117/408 (28.68%), Postives = 191/408 (46.81%), Query Frame = 1
Query:  961 RIVENY--FKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAK-TTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNL--KSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGG-------LELGENIADNTALEISYMSFK----KTGGYVNKF-------DNQMFFFGYAKMFCNRPRKDGNT-RILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            RIV NY   +W   +S  E+ K +          E++  +F++     KQR+P+ K  ++     L  A+    + +   + ++ KN             +L E  R  + ++ W+    K   +EK D M   I YP+ + + + +    K ++    D F+ ++      ++NN   + LL  P+N +    +   +NA+Y   RN I  P GI+Q P F         Y  IG +IGHEI+HGFD  G  FD+ GNL+D    T+  KF ERT C +E+Y +  L G        L  GENIADN  ++ ++ ++K    K GG   +        + Q+FF GYA+++C     +  T  +LTD HSP+  R+    +N   F  A+ C   + +   K+C +W
Sbjct:  368 RIVTNYILLRWAGSWSQ-EIGKKY----------EDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASG--SMYVRKYFDANAKNTTLDMIT------DLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEK-SIQWRNNFYYRRLLE-PVNRFEFISSAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-21 (Neprilysin-21 [Source:UniProtKB/Swiss-Prot;Acc:Q22523])

HSP 1 Score: 138.272 bits (347), Expect = 3.299e-33
Identity = 79/227 (34.80%), Postives = 118/227 (51.98%), Query Frame = 1
Query: 1492 LNGPLNE---YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYN-------EYNLPGGLELGENIADNTALEISYMSFKK-----TG-------GYVNKFDNQMFFFGYAKMFCNRPRKDGNTR-ILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            L+ PL+    + +  +++AYY    N++  P GI+Q P   L + N   Y  +G +IGHE+SH FD  G  +D  GNL D     +  KF E+T CFV +Y        + +L G L LGENIADN  ++ ++ ++K      TG       G+ N    QMFF  YA  +C+  R     + ILTD+H+P KYR + P  N   F  A+ C   + +  ++KC +W
Sbjct:  543 LDQPLDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 769          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Match: nep-21 (Neprilysin-21 [Source:UniProtKB/Swiss-Prot;Acc:Q22523])

HSP 1 Score: 138.272 bits (347), Expect = 3.299e-33
Identity = 79/227 (34.80%), Postives = 118/227 (51.98%), Query Frame = 1
Query: 1492 LNGPLNE---YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYN-------EYNLPGGLELGENIADNTALEISYMSFKK-----TG-------GYVNKFDNQMFFFGYAKMFCNRPRKDGNTR-ILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            L+ PL+    + +  +++AYY    N++  P GI+Q P   L + N   Y  +G +IGHE+SH FD  G  +D  GNL D     +  KF E+T CFV +Y        + +L G L LGENIADN  ++ ++ ++K      TG       G+ N    QMFF  YA  +C+  R     + ILTD+H+P KYR + P  N   F  A+ C   + +  ++KC +W
Sbjct:  543 LDQPLDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 769          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0343930)

HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40
Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query:  961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            R+V NY  W  + S++        +  E + F  IL      +T             R + C++  N+   +++ +L+     N   ++  +      +   +R      +  + W+    +    EK DSM   I YPE++ +   +     ++ I  ++F NN+++ +++  +  L+ LL  P+++     E   +NA+Y   +N I  P GI+Q   +  +      Y  IG +IGHEI+HGFD  G  FD +GN+       ++  F+ERT C +++Y+ Y        + G +  GENIADN  L+ ++ ++KK             +N   +Q+FF  YA+++C   R +D  T+I + +HSP   R+LGP SNS+ F SAY C   + +   +KC +W
Sbjct:  466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0070873)

HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40
Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query:  961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            R+V NY  W  + S++        +  E + F  IL      +T             R + C++  N+   +++ +L+     N   ++  +      +   +R      +  + W+    +    EK DSM   I YPE++ +   +     ++ I  ++F NN+++ +++  +  L+ LL  P+++     E   +NA+Y   +N I  P GI+Q   +  +      Y  IG +IGHEI+HGFD  G  FD +GN+       ++  F+ERT C +++Y+ Y        + G +  GENIADN  L+ ++ ++KK             +N   +Q+FF  YA+++C   R +D  T+I + +HSP   R+LGP SNS+ F SAY C   + +   +KC +W
Sbjct:  466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0070872)

HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40
Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query:  961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            R+V NY  W  + S++        +  E + F  IL      +T             R + C++  N+   +++ +L+     N   ++  +      +   +R      +  + W+    +    EK DSM   I YPE++ +   +     ++ I  ++F NN+++ +++  +  L+ LL  P+++     E   +NA+Y   +N I  P GI+Q   +  +      Y  IG +IGHEI+HGFD  G  FD +GN+       ++  F+ERT C +++Y+ Y        + G +  GENIADN  L+ ++ ++KK             +N   +Q+FF  YA+++C   R +D  T+I + +HSP   R+LGP SNS+ F SAY C   + +   +KC +W
Sbjct:  466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep1 (gene:FBgn0029843 transcript:FBtr0340032)

HSP 1 Score: 161.77 bits (408), Expect = 2.019e-40
Identity = 109/405 (26.91%), Postives = 193/405 (47.65%), Query Frame = 1
Query:  961 RIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLK----IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-------LPGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            R+V NY  W  + S++        +  E + F  IL      +T             R + C++  N+   +++ +L+     N   ++  +      +   +R      +  + W+    +    EK DSM   I YPE++ +   +     ++ I  ++F NN+++ +++  +  L+ LL  P+++     E   +NA+Y   +N I  P GI+Q   +  +      Y  IG +IGHEI+HGFD  G  FD +GN+       ++  F+ERT C +++Y+ Y        + G +  GENIADN  L+ ++ ++KK             +N   +Q+FF  YA+++C   R +D  T+I + +HSP   R+LGP SNS+ F SAY C   + +   +KC +W
Sbjct:  466 RVVHNYMLWRLVMSLMS--HMIDEYQRERVEFRKILMGIQSERT-------------RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVAL-----EMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR-LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Match: Nep3 (gene:FBgn0031081 transcript:FBtr0307554)

HSP 1 Score: 153.68 bits (387), Expect = 5.551e-38
Identity = 86/302 (28.48%), Postives = 155/302 (51.32%), Query Frame = 1
Query: 1255 LTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFKKTGG----------YVNKFDNQMFFFGYAKMFCNRPRKDGN-TRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + E  ++ +++  W+    +++ +EK + +   I +P+ + D   +      + I  N +F N I    +N K+NLK L + P+N+   G     +NAYY   +NQI  P GI+Q P F +N      +  +G ++GHE++H FD  G  +D  GN+       S+ +F E++ C   +Y+ Y      L G   LGENIADN  L+ +Y ++++T             +N   +Q+FF  +A+++C+    + N  ++  D HSP ++R++G  SN K F   + C+   ++   +KC +W
Sbjct:  486 IREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRL-DQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ece2b (endothelin converting enzyme 2b [Source:ZFIN;Acc:ZDB-GENE-131120-140])

HSP 1 Score: 192.586 bits (488), Expect = 1.411e-50
Identity = 175/715 (24.48%), Postives = 316/715 (44.20%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S+ L    VT+ SKI+       ++  R  DPC+DF ++ CG    +N  P      S F  + +    + K L+     N S+    K +++Y SC+N  RI+            + I K           KE F   L+           FT++ S++  ++  N+ Q+ +  ++L  S     N+T  ++ +  ++  +     + G+     G +  I+ FE  +  +     E   E+     IT+ DL+   PA +W        +  +L   +PVV+    AK  ++  +V E  L +K    ++ NY  W        LV+   S  ++   FEN     +  K  +     +K    R   C+   +     +L +L+  +  +   +          + E +  +I+++F        W+    +    +K D++   I +P+ + D K +       ++ +++FF NMIN   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK RT C V++Y +Y     ++ G   LGENIADN  L+ +Y +++    K G       VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP KYR++G  SNS  F   + C   + +    +C +W
Sbjct:   93 SICLTEACVTVASKIV-------EALDRSADPCQDFYQYACGGWVRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAERKTQSYYLSCLNEQRIEELGAQPL----MDLITKIGGWNITESWDKENFLDVLKIISGPYRAQPFFTVSVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLDYMVELGLLLGGDKNSTRGQMQQILDFETALANITVPQDERRDEEKIYHKITIADLQVLAPAIEWLDYLNSVLSPLELNDTEPVVVY---AKEYMQ--QVSE--LINKTDHSLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSK---------EIAEGMINEIRTAFKGALDDLKWMDEQTRQAAKDKADAIYDMIGFPDFILDSKELDDVYDGYEVTEDNFFQNMINFYNFSARVMADQLRKPPNRDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAQDHPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWQNSSVEAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQKNGEEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSGHRCEVW 765          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ecel1 (endothelin converting enzyme-like 1 [Source:ZFIN;Acc:ZDB-GENE-130530-692])

HSP 1 Score: 169.474 bits (428), Expect = 2.252e-43
Identity = 172/674 (25.52%), Postives = 308/674 (45.70%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQN-RKPSLFEEMTNS--MFNIG-------KRLIS-----QSNENYSTKLRNFYKSCINLNRIKR-------KSLNSFKYWYQEFIAKYKERQTLGRT-IKEQFQSQLEFFKSQPPFHQ--LFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLI-KWANVLG---------ESLD-ENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVI----QMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLY-----SSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLN--GPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYR 2007
            V PC DF  F CG   R+  + E+  +   +  IG       +RL+      +  E+   K++ FY+SCIN+  I R       + ++S   W              G   I+  F   L  +K+Q  +     F+L  S++  ++ +N  +I +  + L +  L    Q +  +K +   K L+ +  ++LG         E LD E    NI   EY  D+    SS   + +ITLK L++  P+F W  +    +N  + ++ + +V+     M +   +IKT            S R++ NY  W  + ++ E + T          F + + +FS      +++      L  E  CL  AN++F ++L +L+     SSS +        + ++ +++  +L ++++   W+    KD    K+  M +   YP+ +   + I   E +  +N+  +F N++N++K+N K ++K +               +NAYY+  +NQ+  P GI+Q  ++         Y  IG IIGHE++HG+D  G  +D  GNLK    + S RKF+++T C V+ Y+ +      + G L LGENIAD   L++SY +++K   +V +               Q+FF  +A+ +C + R      ++LTD H+P+ YR
Sbjct:   42 VQPCHDFYSFACGGWLRRHGIPEDKLSYGIITAIGEQNQDKLQRLLQAPVQRRELESAERKVKEFYRSCINIKEIDRLGAGPMTEVIDSCGGWDLSGAPPGGAGWDSGSAPIRPDFNEML--YKTQGVYSTSVFFSLTVSVDDKNSSRNAIRIDQEGLTLPERTLY-LGQDEDSVKILASYKALMERLLSMLGAHNATLKSREILDLETKLANITVSEYE-DQRKDISSM--YNRITLKQLQKMAPSFHWKRLLDRIFN-DNFSEEEEIVVLATDYMQTVSDIIKTT-----------SKRVLHNYMLWRMVAALSEHLSTA---------FRSTIHEFSREIDGTEQQ------LDLERLCLTQANKHFGMALGALFVQQHFSSSSR------AKVQELVEDIKHSLDVRLQELDWMDEETKDAARGKLQHMMVMTGYPDFLLKPELI-DEEYAFDVNEKTYFKNILNSIKYNIKLSIKKIHKEVDKTTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPEFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRYGNLKQWWTEESYRKFQKKTECIVKLYDNFTVYNQRVNGRLTLGENIADLGGLKLSYHAYQK---WVREHGPERPLPGLKHTHEQLFFIAFAQNWCMKRRSQSIYLQLLTDKHAPEHYR 672          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ece1 (endothelin converting enzyme 1 [Source:ZFIN;Acc:ZDB-GENE-061110-100])

HSP 1 Score: 166.392 bits (420), Expect = 4.747e-42
Identity = 176/711 (24.75%), Postives = 307/711 (43.18%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP----------SLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFE-----YMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSF----KKTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            V++ S +L S         R VDPC+DF  F CG    +N  P          +L+E     M N+ +    +S      K + +Y++C+N ++I+           Q+ I +       G   K+ FQ  L    +       FT+  S +S  +  NI Q+ +  + L      L K  N+  L          L++   +LG S D +  +   I++FE       + ++     E  + +I  K+L    PA DW       +   +L   +PVV+    AK  ++  KV E   N+ +S  ++ NY     +  M+ ++   +    E  + E +        T K   P+ KL ++  +  L  A     L + + +S   K                 E++  +IK +F        W+    K    EK D++   + YP+ + + K +        +  + +F N++N   F+ +     L   P  + +  T   +NAYY   +N++ +P GI Q P +         +  IG ++GHE++H FD  G  +D  GNL      +S+  F+ +T C VE+Y+ Y+     L G   LGENIADN  L  +Y ++    KK G       +   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R++G  SNS  F   + C+  + +  K+KC LW
Sbjct:   87 VSVASAVLGSL-------DRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKIEELGAKPL----QDLINQTGGWGLKGPWEKDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNF----LVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPFLSSVFAPVELNDSEPVVVY---AKEYLQ--KVSELISNTNKS--VLNNYMIMKVVRKMVSILDQ-KFQDAEQRFLEVMY------GTKKSCMPRWKLCVSDTDSALGFA--LGALFVKATFSEDSK--------------AFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: ece1 (endothelin converting enzyme 1 [Source:ZFIN;Acc:ZDB-GENE-061110-100])

HSP 1 Score: 166.392 bits (420), Expect = 4.747e-42
Identity = 176/711 (24.75%), Postives = 307/711 (43.18%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP----------SLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFE-----YMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSF----KKTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            V++ S +L S         R VDPC+DF  F CG    +N  P          +L+E     M N+ +    +S      K + +Y++C+N ++I+           Q+ I +       G   K+ FQ  L    +       FT+  S +S  +  NI Q+ +  + L      L K  N+  L          L++   +LG S D +  +   I++FE       + ++     E  + +I  K+L    PA DW       +   +L   +PVV+    AK  ++  KV E   N+ +S  ++ NY     +  M+ ++   +    E  + E +        T K   P+ KL ++  +  L  A     L + + +S   K                 E++  +IK +F        W+    K    EK D++   + YP+ + + K +        +  + +F N++N   F+ +     L   P  + +  T   +NAYY   +N++ +P GI Q P +         +  IG ++GHE++H FD  G  +D  GNL      +S+  F+ +T C VE+Y+ Y+     L G   LGENIADN  L  +Y ++    KK G       +   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R++G  SNS  F   + C+  + +  K+KC LW
Sbjct:   87 VSVASAVLGSL-------DRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKIEELGAKPL----QDLINQTGGWGLKGPWEKDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNF----LVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPFLSSVFAPVELNDSEPVVVY---AKEYLQ--KVSELISNTNKS--VLNNYMIMKVVRKMVSILDQ-KFQDAEQRFLEVMY------GTKKSCMPRWKLCVSDTDSALGFA--LGALFVKATFSEDSK--------------AFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Match: phex (phosphate regulating endopeptidase homolog, X-linked [Source:ZFIN;Acc:ZDB-GENE-030103-2])

HSP 1 Score: 156.377 bits (394), Expect = 6.545e-39
Identity = 132/498 (26.51%), Postives = 224/498 (44.98%), Query Frame = 1
Query:  715 MKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYY------LNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKI-----KSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTG-FEINAYYIFQRNQINVPMGIIQGPIF-QLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-------NLPGGLELGENIADNTALEISYMSF-----KKTGGY-------VNKFDNQMFFFGYAKMFCNRPRKD-GNTRILTDLHSPDKYRILGPTSNSKTFESAYHC-ERXXXXXXXXXCHLW 2103
            MK   ++      +SE  + + +L  L+R  P F+W    +   +      LK     ++S++ VI   +  +Y+      +N+ ++ R V NY  W ++FS +  +   R     +L F  + T      TT       K +   EN  +  A + F   +   +    K++ +           L   +R        K + W+    K + ++K  ++   + YP+ + +  +I    K +     D+F N++  +KF  ++++  L    P  E+FT    +NA+Y    NQI  P G +Q P F  LN      Y  IG I+GHE++HGFD+ G  +D  GNL      +S+ +F E+T C +++YN Y       N+ G   L ENIADN  +  S+ ++     K+ GG        V    NQ+FF  YA + CN  R +    +I +  HSP KYR++G  SN + F  A++C E     +  + C +W
Sbjct:  258 MKLAQIVIPYENRTSENMYNKYSLSKLQRTVPDFNWLGFVRAVIDTELYPDLK-----ISSSEQVI--VRAPQYFKDLFKLINATDT-RTVANYVIWRSVFSRITTLS--RRFLYRYLDFARVTTG-----TTSLTPRWDKCVNYVENTLIYAAGRLF---VDKHFQEDKKHMME----------ELINGIRWAFIDILEKENEWMDEETKRKAIDKAHAVLPKVGYPDFILNDTYINEDIKRLAFTMTDYFGNVMQTLKFIAQSDIGWLRKTVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTHGFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGGIRESFRAYRRWVEKERGGVEEPLLPGVGLTHNQLFFLSYAHVRCNAYRPEAARDQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMNRGAESCRVW 727          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142])

HSP 1 Score: 197.593 bits (501), Expect = 3.490e-52
Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    V++  +IL S         R +DPC+DF ++ CG    R P        + F  + +    I K ++  +  N S+    K + FY SC+   RI   ++K L        + I K       G    E F S L+           F++  S +S  +  NI Q+ +  ++L      L K  N   L+       + ++    +LG S    G+++     I++FE ++  L     E   E+     +T+ +L+   PAFDW        +  DL   +PVV+     K  ++    L   +N+ +   ++ NY  W  +  M     +  S  E+    ++ L +  Y          +K    R   CL   +     +L SL+  S  +   +         N+ E +  +I+ +F        W+    +    EK D++   I +P+ + D K +       +++++ FF NM+N   F+ K   + L   P  E +  T   +NAYY+  +N+I  P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +SL  FK RT C V +YN Y + G    G + LGENIADN  L+ +Y ++K         K    V   +NQ+FF G+A+++C+ R  +  +  ++TD HSP K+R++G  SNSK F   ++C +   +   K C +W
Sbjct:   82 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 755          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142])

HSP 1 Score: 196.438 bits (498), Expect = 3.953e-52
Identity = 190/729 (26.06%), Postives = 321/729 (44.03%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFI----LIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    V++  +IL S         R +DPC+DF ++ CG    R P        + F  + +    I K ++  +  N S+    K + FY SC+   RI   ++K L        + I K       G    E F S L+           F++  S +S  +  NI Q+ +  ++L      L K  N   L+       + ++    +LG S    G+++     I++FE ++  L     E   E+     +T+ +L+   PAFDW        +  DL   +PVV+     K  ++    L   +N+ +   ++ NY  W  +  M     +  S  E+    ++ L +  Y          +K    R   CL   +     +L SL+  S  +   +         N+ E +  +I+ +F        W+    +    EK D++   I +P+ + D K +    L++  + K++++ FF NM+N   F+ K   + L   P  E +  T   +NAYY+  +N+I  P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +SL  FK RT C V +YN Y + G    G + LGENIADN  L+ +Y ++K         K    V   +NQ+FF G+A+++C+ R  +  +  ++TD HSP K+R++G  SNSK F   ++C +   +   K C +W
Sbjct:    8 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDETGLLY--TAKVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 683          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142])

HSP 1 Score: 197.593 bits (501), Expect = 4.554e-52
Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    V++  +IL S         R +DPC+DF ++ CG    R P        + F  + +    I K ++  +  N S+    K + FY SC+   RI   ++K L        + I K       G    E F S L+           F++  S +S  +  NI Q+ +  ++L      L K  N   L+       + ++    +LG S    G+++     I++FE ++  L     E   E+     +T+ +L+   PAFDW        +  DL   +PVV+     K  ++    L   +N+ +   ++ NY  W  +  M     +  S  E+    ++ L +  Y          +K    R   CL   +     +L SL+  S  +   +         N+ E +  +I+ +F        W+    +    EK D++   I +P+ + D K +       +++++ FF NM+N   F+ K   + L   P  E +  T   +NAYY+  +N+I  P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +SL  FK RT C V +YN Y + G    G + LGENIADN  L+ +Y ++K         K    V   +NQ+FF G+A+++C+ R  +  +  ++TD HSP K+R++G  SNSK F   ++C +   +   K C +W
Sbjct:   91 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 764          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142])

HSP 1 Score: 197.208 bits (500), Expect = 5.349e-52
Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    V++  +IL S         R +DPC+DF ++ CG    R P        + F  + +    I K ++  +  N S+    K + FY SC+   RI   ++K L        + I K       G    E F S L+           F++  S +S  +  NI Q+ +  ++L      L K  N   L+       + ++    +LG S    G+++     I++FE ++  L     E   E+     +T+ +L+   PAFDW        +  DL   +PVV+     K  ++    L   +N+ +   ++ NY  W  +  M     +  S  E+    ++ L +  Y          +K    R   CL   +     +L SL+  S  +   +         N+ E +  +I+ +F        W+    +    EK D++   I +P+ + D K +       +++++ FF NM+N   F+ K   + L   P  E +  T   +NAYY+  +N+I  P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +SL  FK RT C V +YN Y + G    G + LGENIADN  L+ +Y ++K         K    V   +NQ+FF G+A+++C+ R  +  +  ++TD HSP K+R++G  SNSK F   ++C +   +   K C +W
Sbjct:   93 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 766          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Match: dhdds (dehydrodolichyl diphosphate synthase subunit [Source:Xenbase;Acc:XB-GENE-1002142])

HSP 1 Score: 195.667 bits (496), Expect = 1.335e-51
Identity = 189/725 (26.07%), Postives = 317/725 (43.72%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    V++  +IL S         R +DPC+DF ++ CG    R P        + F  + +    I K ++  +  N S+    K + FY SC+   RI   ++K L        + I K       G    E F S L+           F++  S +S  +  NI Q+ +  ++L      L K  N   L+       + ++    +LG S    G+++     I++FE ++  L     E   E+     +T+ +L+   PAFDW        +  DL   +PVV+     K  ++    L   +N+ +   ++ NY  W  +  M     +  S  E+    ++ L +  Y          +K    R   CL   +     +L SL+  S  +   +         N+ E +  +I+ +F        W+    +    EK D++   I +P+ + D K   + E    ++++ FF NM+N   F+ K   + L   P  E +  T   +NAYY+  +N+I  P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +SL  FK RT C V +YN Y + G    G + LGENIADN  L+ +Y ++K         K    V   +NQ+FF G+A+++C+ R  +  +  ++TD HSP K+R++G  SNSK F   ++C +   +   K C +W
Sbjct:   59 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTK--ELDEVYDGVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 730          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Ece2 (endothelin converting enzyme 2 [Source:MGI Symbol;Acc:MGI:1101356])

HSP 1 Score: 182.57 bits (462), Expect = 2.823e-47
Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K R+FY SC+   RI++      +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L  S     N+T  E         +++   +LG       E + +   L I      + +      E  + ++++ +L+   PA DW        +  +L   +PVV+  T      +  + +   +N  E   I+ NY  W  +       KT  S  +     +  L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+S+F  T  D      K RL   EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y + G    GL+ LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:   98 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Ece2 (endothelin converting enzyme 2 [Source:MGI Symbol;Acc:MGI:1101356])

HSP 1 Score: 182.185 bits (461), Expect = 3.009e-47
Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K R+FY SC+   RI++      +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L  S     N+T  E         +++   +LG       E + +   L I      + +      E  + ++++ +L+   PA DW        +  +L   +PVV+  T      +  + +   +N  E   I+ NY  W  +       KT  S  +     +  L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+S+F  T  D      K RL   EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y + G    GL+ LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:   69 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 734          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Gm49333 (predicted gene, 49333 [Source:MGI Symbol;Acc:MGI:6121518])

HSP 1 Score: 182.57 bits (462), Expect = 6.129e-47
Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K R+FY SC+   RI++      +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L  S     N+T  E         +++   +LG       E + +   L I      + +      E  + ++++ +L+   PA DW        +  +L   +PVV+  T      +  + +   +N  E   I+ NY  W  +       KT  S  +     +  L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+S+F  T  D      K RL   EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y + G    GL+ LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:  216 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 881          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Gm49333 (predicted gene, 49333 [Source:MGI Symbol;Acc:MGI:6121518])

HSP 1 Score: 182.57 bits (462), Expect = 8.408e-47
Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K R+FY SC+   RI++      +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L  S     N+T  E         +++   +LG       E + +   L I      + +      E  + ++++ +L+   PA DW        +  +L   +PVV+  T      +  + +   +N  E   I+ NY  W  +       KT  S  +     +  L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+S+F  T  D      K RL   EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y + G    GL+ LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:  245 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Match: Ece1 (endothelin converting enzyme 1 [Source:MGI Symbol;Acc:MGI:1101357])

HSP 1 Score: 178.718 bits (452), Expect = 5.622e-46
Identity = 167/718 (23.26%), Postives = 307/718 (42.76%), Query Frame = 1
Query:  103 LILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYSTKLRN---FYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILIN--KQLIKWANVLGESLDENG----ALNIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSF----KKTGG-----YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            L    V++ S IL+S           VDPC+DF  + CG     N  P        F  +      + K L+  +  + S   R    +Y++C+N  RI+            E I K       G   K+ FQ  L+   +       F++  S +S ++  N+ Q+ +  + L     ++    K E +++L      +++   +LG   DE+        I+ FE  +  +          EL + ++T  +L+   PA +W   +  I+Y V ++ + +P+V+     K  ++    L   +N+ +   ++ NY  W  +      L + F+   E+ +       +  Y          +K  + R  FC+         +L  ++  +            +  +N+   + ++IK +F        W+    +    EK D++   I YP  + D K +           + +F N +    F+++     L   P  + +  T   +NAYY   +N+I  P GI+Q P +  +  N   +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK++T C V++Y+ Y++ G        LGENIADN  L+ +Y ++    KK G       +    NQ+FF G+A+++C+ R  +  +  ++TD HSP ++R++G  SNSK F   + C   + +    KC +W
Sbjct:   83 LTEACVSVTSSILNSMDPT-------VDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKAQVYYRACMNETRIEELRAKPL----MELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS---RDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-DEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV-EINESEPIVVY---DKEYLRQVSTL---INNTDKC-LLNNYMMWNLVRKTSSFLDQRFQDADEKFM-------EVMYG--------TKKTCIPRWKFCVSDTENNLGFALGPMFVKAT---------FAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 753          
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|P42891|ECE1_BOVIN (Endothelin-converting enzyme 1 OS=Bos taurus OX=9913 GN=ECE1 PE=1 SV=2)

HSP 1 Score: 189.504 bits (480), Expect = 9.376e-49
Identity = 174/720 (24.17%), Postives = 308/720 (42.78%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYSTKLRN---FYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILIN--KQLIKWANVLGESLDEN---GALNIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSF----KKTGG-----YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S+ L    +++ S ILSS           VDPC+DF  + CG     N  P        F  +      I K L+  S  + S   R    +Y++C+N  RI+            E I K       G   K+ FQ  L+   S       F++  S +S ++  N+ Q+ +  + L     ++    K E +++L      +++   +LG   ++        I+ FE  +  +          EL + ++T  +L+   PA +W   +  I+Y V ++ + +P+VI      S + T       +NS +   ++ NY  W  +      L + F+   E+ +       +  Y          +K  L R  FC+         +L  ++  +            +  +N+   + L+IK +F        W+    +    EK D++   I YP  + D K +           + +F N +    F+++     L   P  + +  T   +NAYY   +N+I  P GI+Q P +  +  N   +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK++T+C VE+Y  Y++ G        LGENIADN  L+ +Y ++    KK G       +   +NQ+FF  +A+++C+ R  +  +  ++TD HSP ++R++G  SNSK F   +HC   + +    KC +W
Sbjct:   81 SVCLSEACISVTSSILSSMDPT-------VDPCQDFFTYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELKAKPL----MELIEKLGGWNITGPWDKDNFQDTLQVVTSHYHTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS---RDYYLNKTENEKVLTGYLNYMVQLGKLLGGGAEDTIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV-EINESEPIVIYDKEYLSKVSTL------INSTDKC-LLNNYMIWNLVRKTSSFLDQRFQDADEKFM-------EVMYGT--------KKTCLPRWKFCVSDTENTLGFALGPMFVKAT---------FAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTACMVEQYGNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLSFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSISNSKEFSEHFHCPPGSPMNPHHKCEVW 754          
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|B2RQR8|ECE2_MOUSE (Endothelin-converting enzyme 2 OS=Mus musculus OX=10090 GN=Ece2 PE=1 SV=1)

HSP 1 Score: 182.57 bits (462), Expect = 1.975e-46
Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K R+FY SC+   RI++      +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L  S     N+T  E         +++   +LG       E + +   L I      + +      E  + ++++ +L+   PA DW        +  +L   +PVV+  T      +  + +   +N  E   I+ NY  W  +       KT  S  +     +  L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+S+F  T  D      K RL   EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y + G    GL+ LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:   98 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763          
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|P42893|ECE1_RAT (Endothelin-converting enzyme 1 OS=Rattus norvegicus OX=10116 GN=Ece1 PE=1 SV=2)

HSP 1 Score: 182.185 bits (461), Expect = 2.978e-46
Identity = 172/713 (24.12%), Postives = 307/713 (43.06%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST---KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILIN--KQLIKWANVLGESLDENG----ALNIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLE-LVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSF----KKTGG-----YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            V++ S IL+S           VDPC+DF  + CG     N  P        F  +      I K L+  S  + S    K + +Y++C+N  RI+            E I K       G   K+ FQ  L+   +       F++  S +S ++  N+ Q+ +  + L     ++    K E +++L      +++   +LG   DE+        I+ FE  +  +          EL + ++T  +L+   PA +W   +  I+Y V ++ + +P+V+     K  ++    L   +NS +   ++ NY  W  +      L + F+   E+ +       +  Y          +K  L R  FC+         +L  ++  +            +  +N+   + L+IK +F        W+    +    EK D++   I YP  + D K +           + +F N +    F+ +     L   P  + +  T   +NAYY   +N+I  P GI+Q P +  +  N   +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK++T C V++YN Y++ G        LGENIADN  L+ +Y ++    KK G       +    NQ+FF G+A+++C+ R  +  +  ++TD HSP ++R++G  SNSK F   + C   + +  + KC +W
Sbjct:   97 VSVTSSILNSMDPT-------VDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPL----MELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS---RDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-DEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPV-EINESEPIVVY---DKEYLRQVSTL---INSTDKC-LLNNYMMWNLVRKTSSFLDQRFQDADEKFM-------EVMYGT--------KKTCLPRWKFCVSDTENNLGFALGPMFVKAT---------FAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 762          
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|P0DPD9|EFCE2_MOUSE (EEF1AKMT4-ECE2 readthrough transcript protein OS=Mus musculus OX=10090 GN=Eef1akmt4-Ece2 PE=1 SV=1)

HSP 1 Score: 182.57 bits (462), Expect = 4.287e-46
Identity = 176/708 (24.86%), Postives = 307/708 (43.36%), Query Frame = 1
Query:  118 VTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG-------ESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSD------KDRLV--EKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K R+FY SC+   RI++      +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L  S     N+T  E         +++   +LG       E + +   L I      + +      E  + ++++ +L+   PA DW        +  +L   +PVV+  T      +  + +   +N  E   I+ NY  W  +       KT  S  +     +  L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+S+F  T  D      K RL   EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y + G    GL+ LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:  216 IRVAGKIL-------ESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLR----DLIDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFL-PSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGT------EYLQQVSELINRTEP-SILNNYLIWNLV------QKTTSSLDQRFETAQEKLLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 881          
BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Match: sp|F1N476|ECE2_BOVIN (Endothelin-converting enzyme 2 OS=Bos taurus OX=9913 GN=ECE2 PE=2 SV=1)

HSP 1 Score: 179.104 bits (453), Expect = 3.231e-45
Identity = 169/720 (23.47%), Postives = 302/720 (41.94%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYL------IQSLLKEKNQTK----LEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFK----KTG-----GYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            S  L    + +  KIL       +S  R V PC+DF +F CG    R P        + F  + +    I K L+  +  N S+    K + FY SC+ + RI+       +    + I K       G   ++ F   L+           FT+  S +S  +  NI Q+ +  ++L      +     EK  T     +E   +L+  Q       + + L+    L I      + +      E  + ++++ +L+   P+ DW        +  +L   +PVV+  T     +         L ++    ++ NY  W  +  +   L   F S  E+       L +  Y          +K    R   C+   +     +L SL+  +  +   +          + E +  +I+++F        W+    +    EK D++   I +P+ + + K +       +++++ FF NM+N   F+ K     L   P  + +  T   +NAYY+  +N+I  P GI+Q P +  N      +  IG ++GHE++H FD  G  +D +GNL+      SL  F+  T+C  E+Y++Y      L G   LGENIADN  L+ +Y ++K    K G       V   ++Q+FF G+A+++C+ R  +  +  ++TD HSP ++R+LG  SNS+ F   + C   + +   + C +W
Sbjct:   92 STCLTEACIRVAGKIL-------ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTQRFYLSCLQVERIEELGAQPLR----DLIDKIGGWNVTGPWDQDNFMEVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGQPTSTREQMRQVLE----LEIQLANITVPQDQRRDEEKIYHKMSIAELQALAPSMDWLEFLSFLLSPLELGDSEPVVVYGTDYLQQVSE-------LINRTEPSVLNNYLIWNLVQKTTSSLDHRFESAQEK-------LLETLYGT--------KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSK---------EIAEGMISEIRAAFEEALGHLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYTCNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACIEEQYSQYQVNGEKLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNSGQLCEVW 765          
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: A0A336KGD2 (CSON003355 protein OS=Culicoides sonorensis OX=179676 GN=CSON007349 PE=4 SV=1)

HSP 1 Score: 203.756 bits (517), Expect = 1.531e-50
Identity = 183/726 (25.21%), Postives = 326/726 (44.90%), Query Frame = 1
Query:   73 KSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG---------QNRKP-SLFEEMTNSMFNIGKRLISQS---NENYST-KLRNFYKSCINLNRIKRKSLNSF--KYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-IMKFEYMIDKLWGESSELG-----FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQ----MTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            K+ N+  ++ L    VT  S +LS+         R  DPCKDF +F CG         ++R   S FE + +    I K ++ +    N+N +T K + FYKSC++L +I++  +  F     Y       ++  T      E    +L    S+P   + +  A   NS     NI Q+ +  + L       K+ ++ ++K    ++ + + A +LG S D    LN I++FE  +       ++       + ++TL +L +  P  DW    +       L + +PVV+     + S   ++KT              R + NY  W    SM+        +  E + F  IL      +              R + C++  N+   +++ +L+     N   ++  +  I  N+ E     +    W+    +    EK D+M   I YPE++ +   +     ++ I++N+F NN++N ++++   N++ LL  P+++     E   +NA+Y   +N I  P GI+Q   +  N      Y  IG +IGHE++HGFD  G  FD  GN+       +++ F+ER  C +++Y+ Y +        G +  GENIADN  L+ ++ +++K   +V+K              +Q+FF  YA+++C   R +D  T+I + +HSP   R++GP SNSK F  AY+C   + +    KC +W
Sbjct:  187 KNSNDNTNICLTEDCVTAASSLLSAM-------DRTADPCKDFFQFACGVWNKKHLIPEDRSSISTFEVLADQQQVILKGVLEEPLDENDNKATIKAKMFYKSCMDLQQIRKIGIQPFLDVLKYLGGWPVIEKNWTAPNFSIEWLMGRLRGEFSEPVLIEFYVGADDKNS---SSNILQLDQLVLALPSRDYYLKSSSEGDLK--AYHRYMTQIARLLGASSDAYKELNDIIQFEIRLANASSPEADRHDTSAIYRKLTLTELAKEVPEIDWREYLQETVGDIKLKRDEPVVVYALPYLVSLGKILKTT-----------DRRTIHNYLLWRLTMSMM--THMIDEYQRERVEFRKILLGIQSERH-------------RWSQCVEWTNKKLGMAVGALFIRDNFNQVSKETALEMIH-NIREAFNELLADIHWMDDETRAVAKEKADAMNERIGYPEILTNPPELEKEYVNLTIDENNFLNNVLNILRWDAHRNMQ-LLRKPVDKNKWATEPAVVNAFYNPNKNDIVFPAGILQPLFYSQNFPKSLNYGGIGVVIGHEVTHGFDDKGRQFDKDGNMMQWWNNATIKAFRERAQCIIDQYSRYKIDEVGLYMNGRMTQGENIADNGGLKQAFRAYRK---WVDKHGPEARLPGLNLTHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGIIRVIGPLSNSKDFAEAYNCPLGSPMNPTSKCSVW 869          
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: W8BVC8 (Membrane metallo-endopeptidase-like 1 OS=Ceratitis capitata OX=7213 GN=MMEL1 PE=2 SV=1)

HSP 1 Score: 202.601 bits (514), Expect = 3.975e-50
Identity = 191/735 (25.99%), Postives = 334/735 (45.44%), Query Frame = 1
Query:  109 LLIVTIGSKILSSSKKDGKSNQRFV---------------------DPCKDFNRFVCG---------QNRKP-SLFEEMTNSMFNIGKRLISQS---NENYST-KLRNFYKSCINLNRIKR-------KSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFEY-MIDKLWGES----SELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFS-MLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-------GGLELGENIADNTALEISYMSFKK---------TGGYVNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            L + ++GS + +++K D K  QR V                     DPC +F +F CG         ++R   S FE +++    + K ++ +S   ++N +T K + FYKSC++L +I++         L S   W           Q    TI EQ    L    S+P   +L+  A   NS     NI QI +PQ+ L       K  ++ ++K  L  K + + A +LG S    G     +++FE  +++    E+    +   + +ITL +L+R  P  +W +  +      D+  L   ++   +   +++  K+LE     K   R+V N+  W  + S M  ++  F+    E + F  IL      +              R + C++  N+   L++ +L+     N   +   +  I   L E     +  + W+    +    EK ++M   I YPE++ +   +    +++ I  ++F  N++N +K++ + NL+ LL+ P+++     E   +NA+Y   +N I  P GI Q   +  N      Y  IG +IGHEI+HGFD  G  FD  GN+       ++  F+ERT C +++Y+ Y +        G +  GENIADN  L+ ++ ++KK             +N   +Q+FF  YA+++C   R +D  T+I + +HSP   R+L P SNSK F  AY C+  + +   +KC +W
Sbjct:  184 LTMASVGSSVQAATK-DIKPRQRDVCLTEDCVRTAASLLSAMDTTADPCTNFFQFACGTWNKIHIIPEDRSSISTFEVLSDEQQVVLKGVLEESIKDDDNIATIKAKQFYKSCMDLPQIRKIGEGRLMDVLKSLGGWP----VITPNWQPPNMTI-EQLMGILRGVYSEPVLVELYVGADDKNS---SINILQIDQPQLALPSRDYYLKPSSENDLKAYL--KYMTQTAILLGASPATAGKELDEVLQFEIKLVNASLPEADRHDTSAIYNKITLPELQRQVPQLNWTVFLQTVLG-PDIELLPDELLVSYAMPYLVEMGKILE-----KADRRVVHNFVIWRLVMSIMAHMIDEFQ---RERIEFRKILLGVQSERM-------------RWSQCVEWTNKKLGLAVGALFIRDNFNQESKDTALEMIH-TLREAFNELLTENHWMDDETRAVAREKANAMNERIGYPEILNNATELAKEYENLTIVPDNFMENVLNILKWDSEKNLQ-LLHQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGIFQPLFYSNNYPKSVNYGGIGVVIGHEITHGFDDKGRQFDKDGNMMQWWNNATIEAFRERTQCIIDQYSRYKIEEVDMYVNGRMTQGENIADNGGLKQAFRAYKKWVKRHGPEPELPGLNLTHDQLFFLNYAQIWCGSMRPEDAVTKIRSSVHSPGFIRVLAPLSNSKDFAEAYKCKLGSPMNPVEKCSVW 883          
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: Q17AS1 (AAEL005207-PA OS=Aedes aegypti OX=7159 GN=5566104 PE=4 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 5.075e-49
Identity = 179/687 (26.06%), Postives = 321/687 (46.72%), Query Frame = 1
Query:  175 RFVDPCKDFNRFVCGQ-NRKP---------SLFEEMTNSMFNIGKRLISQS---NENYST-KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIA--KYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLG--ESLDENGALNIMKFEYMI------DKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE---INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKY-----NEYNL--PGGLELGENIADNTALEISYMSFKKTGGY---------VNKFDNQMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            R VDPCKDF +F CG  N+K          S FE + +    I K ++ +S   N+N +T K + FYKSC++L +I++  +N  +   +        ++   L  T  E     L    S+P   +L+  A   NS    KNI QI +  + L       K  ++ ++K    +  + + A +LG   ++     + ++ FE  +      +    ++S + +++ITL+ L++  P  +W    +       L + + +V    +   +I+  ++L   +  K   RI+ NY  W  + S++        + +E + F  IL      +              R + C++  N+   +++ +L+     N   ++  +  I   + E     +    W+    +    EK D+M   I YPE++ + + +     ++ I K+ F NN++N +K++ + NL+ LL  P+++     E   +NA+Y   +N I  P GI+Q   +  +      Y  IG +IGHEI+HGFD  G  FD  GN+       +++ F+ER  C +++Y     NE NL   G +  GENIADN  L+ S+ +++K   +         +N   +Q+FF  YA+++C   R +D  T+I + +HSP   R++GP SNSK F  AY+C   + +    KC +W
Sbjct:  170 RTVDPCKDFFQFACGTWNKKHVIPEDRSSISTFEVLADQQQVILKGVLEESVDVNDNQATLKAKMFYKSCMDLQQIRKIGINPIRNVLKSLGGWPVIEQNWVLPNTSIEHLIGTLRGVYSEPVLVELYVGADDKNS---SKNILQIDQLVLALPSRDYYLKQSSEGDLKAY--HHYMTQIAILLGGDPTIASKELMEVINFEVRLANASLPEADRHDTSAI-YKKITLQQLQKQVPQINWKEYLQTTLGSVKLEENEAIV--SYAMPYLIEMGRILN--MTDK---RIIHNYAIWRFVMSIM--THMIDDYQKERVEFRKILLGIQSERH-------------RWSQCVEWTNKKLGMAVGALFIRDNFNQESKETALEMIH-TIREAFNELLADIHWMDDETRAVAKEKADAMNERIGYPEILTNPEELEKEYINLTIFKDHFINNILNILKWDAERNLQ-LLRKPVDKDKWATEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKDGNMMQWWNNATIKAFRERAQCIIDQYSRYKINEVNLFMNGRMTQGENIADNGGLKQSFRAYRKWVDFHGPELDLPGMNMSHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGIIRVIGPLSNSKDFAEAYNCPYGSPMNPLNKCSVW 826          
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: F7E009 (Dehydrodolichyl diphosphate synthase subunit OS=Xenopus tropicalis OX=8364 GN=guca1c PE=4 SV=2)

HSP 1 Score: 197.593 bits (501), Expect = 5.479e-49
Identity = 188/725 (25.93%), Postives = 317/725 (43.72%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG--QNRKP--------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRI---KRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    V++  +IL S         R +DPC+DF ++ CG    R P        + F  + +    I K ++  +  N S+    K + FY SC+   RI   ++K L        + I K       G    E F S L+           F++  S +S  +  NI Q+ +  ++L      L K  N   L+       + ++    +LG S    G+++     I++FE ++  L     E   E+     +T+ +L+   PAFDW        +  DL   +PVV+     K  ++    L   +N+ +   ++ NY  W  +  M     +  S  E+    ++ L +  Y          +K    R   CL   +     +L SL+  S  +   +         N+ E +  +I+ +F        W+    +    EK D++   I +P+ + D K +       +++++ FF NM+N   F+ K   + L   P  E +  T   +NAYY+  +N+I  P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +SL  FK RT C V +YN Y + G    G + LGENIADN  L+ +Y ++K         K    V   +NQ+FF G+A+++C+ R  +  +  ++TD HSP K+R++G  SNSK F   ++C +   +   K C +W
Sbjct:   82 SLCLSEACVSVAGRILDSL-------DRGIDPCQDFYQYSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENATFNSSSEAEMKTQRFYLSCLKEQRIEELRQKPLT-------DLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFFSVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL----QYMVSVGELLGGS---PGSVDMQMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPVVVY---GKEYLQQVSEL---VNNTDPM-LLNNYLVWNLVQKM---SSSLDSRFEKA---QDKLLESLYGA--------KKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSK---------NIAEQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTHPKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 755          
BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Match: A0A0B2W080 (Endothelin-converting enzyme 1 OS=Toxocara canis OX=6265 GN=ECE1 PE=4 SV=1)

HSP 1 Score: 197.978 bits (502), Expect = 5.928e-49
Identity = 180/739 (24.36%), Postives = 311/739 (42.08%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQ---NRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRN---------------FYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGE----------SLDENGALN-----IMKFEY---MIDKLWGE--SSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEE--HLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYS--------------SSVKNXXXXXXXXXXXXXN-----------------LTENLRLKIKSSF---------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF----TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNE-----YNLPGGLELGENIADNTALEISY---------MSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
             D C+DF  F CG+   +  P++     N +   G   + Q  +     L N                Y +CIN  R+++  L  +  + Q       ++  + + ++E   S   + KS  P   L  L + ++  +T K++  I  P   LI   L       +  + + +N    ++   + E          +++ +  LN     +++FE+   M      E  +S+  +    L+ L    P  +W +     Y    + K +P+VI+    K + +   VL  Y +S+   R VENY KW +I   L+ V    + H     LYFE  L +F+ +               R  FCL       P    S++               S ++N  ++         +                 L  ++R  ++ +F         WL    K  ++ K+++M   I YPE + D + +    + + +N+ D F +M+NA +F+ +  LK L    +   +    +   INA Y F+RN I +PM I + P    ++  +  Y+ IG IIGHE+SH FD  G   D  GNL+D   + S+R+F  R+ CFV++Y+E     Y +     L ENI DN  L+++Y          SF+  G   N   +Q FF  YA+ +C   + D   ++  ++HS D  R+LGP  NS  F +A+HC   + +  ++KC +W
Sbjct:   85 ADACEDFFEFACGRWVRDVTPTIATPQWNVVIATGIAALRQLAKRLDELLLNTSSLKINSAEEKAISLYAACINEERLRQLGLRPWLAFVQSIGGWNPQKVFVAQPLEEILLSL--YAKSTYP---LIWLGSLVDDKNTTKHVITIDEPVPSLIYVHLYRNTSLPVTAENV-VNGNCSEFLRAIYEMSVYMAVGLLNIEPSTELNKSIAEMIEFEWRTVMAGSAMDEEKTSKQVYYSTDLQTLNEIAPFLNWSLFLNRVYETERIGKREPIVIK-KGTKWLQRLNAVLTEYQSSERGRRTVENYVKWRSILMHLQYVMLDCTKHPRGMQLYFERFLFNFALSGH-------------RNLFCLLRVTNLLPNPFASIFRKIMPEQEQKNKQLVSDIRNNVRKAFVSEVEEHDEWLEEKTKLSVLRKNKQLVSDIRNNVRKAFVSEVEEHDEWLEEKTKLSVLRKLENMESLISYPEDIYDEEAMEKEYRELMVNRTDMFWSMVNASRFSRQVGLKRLRKRVVRSSWLDNASPLTINALYNFERNIIILPMMITRPPFADFDVPMLFNYASIGSIIGHEMSHAFDVTGRQHDENGNLRDTWAQQSIRQFDVRSQCFVQQYSEFAKQGYQINASETLNENIGDNVGLKLAYKAWKSQETQASFRLPGTNFNA--DQAFFVAYAQTWCG--KNDAQRKLHLEVHSLDSLRVLGPIQNSDEFANAFHCPIGSAMNPQRKCGIW 799          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399])

HSP 1 Score: 196.438 bits (498), Expect = 5.683e-52
Identity = 184/722 (25.48%), Postives = 326/722 (45.15%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    VT+ SKI+ S         R VDPC+DF ++ CG    +N  P      S F  + +    + K L+     N S+    K + +Y SC+N  RI+            + IAK           K+ F   L+     +++QP     FT+  S++  ++  N+ Q+ +  ++L  S     N+T  ++ +  ++  +++   +LG   D+N   N    I+ FE  +  +     E   E+     IT+ +L+   PA +W        +  +L   +PVV+    AK  ++  +V E  L +K    ++ NY  W        LV+   S  ++   FEN     +  K  +     +K    R   C+   +     +L +L+ ++  +   +          + E +  +I+++F        W+    +    EK D +   I YP+ + D K +        +++++FF NM+N   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK RT C V++Y +Y     ++ G   LGENIADN  L+ +Y +++   KT G       VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP KYR++G  SNS  F   ++C   + +    +C +W
Sbjct:   91 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVVY---AKEYLQ--QVSE--LINKTDRNLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVNATFDKHSK---------EIAEGMINEIRTAFQDALDHLNWMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 763          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399])

HSP 1 Score: 196.438 bits (498), Expect = 6.429e-52
Identity = 184/722 (25.48%), Postives = 326/722 (45.15%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    VT+ SKI+ S         R VDPC+DF ++ CG    +N  P      S F  + +    + K L+     N S+    K + +Y SC+N  RI+            + IAK           K+ F   L+     +++QP     FT+  S++  ++  N+ Q+ +  ++L  S     N+T  ++ +  ++  +++   +LG   D+N   N    I+ FE  +  +     E   E+     IT+ +L+   PA +W        +  +L   +PVV+    AK  ++  +V E  L +K    ++ NY  W        LV+   S  ++   FEN     +  K  +     +K    R   C+   +     +L +L+ ++  +   +          + E +  +I+++F        W+    +    EK D +   I YP+ + D K +        +++++FF NM+N   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK RT C V++Y +Y     ++ G   LGENIADN  L+ +Y +++   KT G       VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP KYR++G  SNS  F   ++C   + +    +C +W
Sbjct:   93 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVVY---AKEYLQ--QVSE--LINKTDRNLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVNATFDKHSK---------EIAEGMINEIRTAFQDALDHLNWMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 765          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399])

HSP 1 Score: 196.052 bits (497), Expect = 1.072e-51
Identity = 184/722 (25.48%), Postives = 326/722 (45.15%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            SL L    VT+ SKI+ S         R VDPC+DF ++ CG    +N  P      S F  + +    + K L+     N S+    K + +Y SC+N  RI+            + IAK           K+ F   L+     +++QP     FT+  S++  ++  N+ Q+ +  ++L  S     N+T  ++ +  ++  +++   +LG   D+N   N    I+ FE  +  +     E   E+     IT+ +L+   PA +W        +  +L   +PVV+    AK  ++  +V E  L +K    ++ NY  W        LV+   S  ++   FEN     +  K  +     +K    R   C+   +     +L +L+ ++  +   +          + E +  +I+++F        W+    +    EK D +   I YP+ + D K +        +++++FF NM+N   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK RT C V++Y +Y     ++ G   LGENIADN  L+ +Y +++   KT G       VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP KYR++G  SNS  F   ++C   + +    +C +W
Sbjct:  114 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVVY---AKEYLQ--QVSE--LINKTDRNLLNNYMIWN-------LVQKGASSLDQR--FEN-----AQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVNATFDKHSK---------EIAEGMINEIRTAFQDALDHLNWMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 786          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:103045399])

HSP 1 Score: 164.081 bits (414), Expect = 2.009e-41
Identity = 90/287 (31.36%), Postives = 151/287 (52.61%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---KTGG------YVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            W+    +    EK D +   I YP+ + D K +        +++++FF NM+N   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK RT C V++Y +Y     ++ G   LGENIADN  L+ +Y +++   KT G       VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP KYR++G  SNS  F   ++C   + +    +C +W
Sbjct:  442 WMDDQTRKAAKEKADDIYDMIGYPDFILDPKELDDVYDGYDVSEDNFFQNMLNFYNFSARVMADQLRKPPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYARDHPKALNFGGIGVVMGHELTHAFDDQGREYDKTGNLRPWWQNSSVDAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVKTNGEEKSLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPDFSQHFNCPLGSPMNSGHRCEVW 728          

HSP 2 Score: 51.6026 bits (122), Expect = 4.126e-6
Identity = 70/291 (24.05%), Postives = 124/291 (42.61%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN----IMKFEYMIDKLWGESSELGFEQ-----ITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVI 885
            SL L    VT+ SKI+ S         R VDPC+DF ++ CG    +N  P      S F  + +    + K L+     N S+    K + +Y SC+N  RI+            + IAK           K+ F   L+     +++QP     FT+  S++  ++  N+ Q+ +  ++L  S     N+T  ++ +  ++  +++   +LG   D+N   N    I+ FE  +  +     E   E+     IT+ +L+   PA +W        +  +L   +PVV+
Sbjct:   93 SLCLTEACVTVASKIVESL-------DRTVDPCQDFYQYACGGWIRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAEKKAQFYYLSCLNEQRIEELGAQPLV----DLIAKTGGWNITETWDKDNFMDVLKTVSGPYRAQP----FFTVGVSVDPKNSNSNVIQVDQSGLFL-PSRDYYLNKTNEKVLKAYLD-YMVELGLLLGG--DKNSTQNQMQQILDFETALANITVPQDERRDEEKIYHKITIAELQTLAPAVEWLDYLSSVLSPLELNDTEPVVV 364          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Match: ece1 (endothelin converting enzyme 1 [Source:ZFIN;Acc:ZDB-GENE-061110-100])

HSP 1 Score: 163.31 bits (412), Expect = 2.199e-41
Identity = 175/724 (24.17%), Postives = 299/724 (41.30%), Query Frame = 1
Query:   91 LSLFLILLIVTIG-------------SKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNEN----YSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQS---LLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL--NIMKFEYMIDKLW-----GESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            LSL L + I+T+G                +S +     +  R VDPC DF  F CG    +N  P        F  +      I K L+  +N+        K + +Y++C++  RI+           QE I +       G   KE FQ  L    +       FT+  S +S ++  NI Q+ +  + L      L K  N+  L+         L++   +LG S + +  +   I+ FE  +  +          EL + +I  K+L    PA DW    +  +    L   +PVV+  T         KV +   N+ +S   + NY     +  M+ ++   R    E  + E +        T K   P+ KL       C+   +     +L +L+  +            +  +   E++  +IK +F        W+ G  K    EK D++   I YP+ + D K +       ++  + +F N+++   F+ +     L   P  + +  T   +NAYY   +N++ +P GI+Q P +         +  IG ++GHE++H FD  G  +D  GNL+     +S+  FK +T C VE+Y+ Y+     L G   LGENIADN  L+ +Y                       K++C+ R  +  +  ++TD HSP ++R++G  SNS  F   ++C+  + +  K+KC LW
Sbjct:   16 LSLALFICILTLGLHYNETHPGVCLSEPCVSVAAAVMGALDRSVDPCTDFYNFACGGWVKKNPLPEGKSRWGPFSNLWEQNMAIMKSLLENTNQQGLSKAELKAQRYYQACMSEARIEELGSQPL----QELINQTGGWALTGPWDKENFQEVLRIVSANYRTSPFFTVFVSTDSKNSTSNIIQVDQSGLGLPSREYYLNKTANEKYLKAYLGF----LVELGVLLGGSEETSRRMMQEIVDFETSLANITVPQEERRDEELIYHKIQAKNLSSLAPAVDWMPFLRAVFAPVSLNDSEPVVVYATEYLQ-----KVSQLITNTNKS--TLNNYMMMKVVRKMVSILDQ-RFQDAEQRFLEVMY------GTKKSCTPRWKL-------CVSDTDSALGFALGALFVKAT---------FAEDSKAFAEDMVSEIKWAFEDSLKQVGWMDGDTKKAAKEKADAIYNMIGYPKFIMDPKELDKVFNDFEVVSDLYFKNVMHYYNFSGRVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGILQAPFYSRAWPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWKNSSVEAFKRQTRCMVEQYSNYSVNNEPLNGKHTLGENIADNGGLKAAY-----------------------KVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHDFSKHFNCKADSPMNPKRKCELW 678          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: ecel1 (endothelin converting enzyme-like 1 [Source:ZFIN;Acc:ZDB-GENE-130530-692])

HSP 1 Score: 160.999 bits (406), Expect = 3.861e-42
Identity = 129/469 (27.51%), Postives = 213/469 (45.42%), Query Frame = 1
Query:  769 FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSM-LELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTGFE-INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFKK------------TGGYVNKFDNQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKY---RILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + ++ L+DL    PA D  I W+ +       ++      +  A + IK       +L S    R++ NY  W  +  +   L   FR+           L DFS      ++E      +  E  CL  AN+YF + L +L+          +Q + Q+ +++      +++   W+    KD    K   M   I YPE +  R   +  E   ++N+  +F N++N+++FN   ++  +      N +    + +NAYY+   NQ+  P GI+Q  ++         Y  IG IIGHE++HG+D  G  +D  GNLK      S  KF ERT C V+ YN +     N+ G L LGENIAD   L+++Y +++K               Y ++   Q+FF  +A+ +C + R      ++LTD HSP+ Y   R+LG  S    F   +HC R + +  + KC +W
Sbjct:   77 YNKMKLRDLHHLAPAHD-QINWRQFLEQIFRKRISEDEEVVVLATTYIKKLS----HLLSTTPVRVLHNYMLWRVVIVLSTHLSPPFRA----------ALHDFSREVDGAEKE------VDLERLCLAQANKYFGMVLGALFVRE-HFSLHSKQRVQQMVEDIKHAFDQRLEELGWMDEKTKDAARGKFQLMMDMIGYPEFLG-RMDEVDKEYGFEVNEKSYFKNILNSIEFNINVSIHKIHQKVERNVWLLPPQTLNAYYLPTHNQMVFPAGILQPTLYDPEFPQSMNYGGIGTIIGHELTHGYDDWGGQYDRHGNLKQWWTAESYGKFLERTECVVKLYNNFTINKQNVNGKLTLGENIADMGGLKLAYHAYQKWVRENGPEPPLQGMAYTHE---QLFFVAFAQNWCMKRRPQSLYLQLLTDKHSPENYSRRRVLGSASQFDEFGRVFHCRRGSPMSPQHKCSVW 519          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: mmel1 (membrane metallo-endopeptidase-like 1 [Source:ZFIN;Acc:ZDB-GENE-101112-2])

HSP 1 Score: 159.458 bits (402), Expect = 1.187e-40
Identity = 96/293 (32.76%), Postives = 155/293 (52.90%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEK--SIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTGFEI-NAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYN--EYNLPGGLE------LGENIADNTALEI---SYMSFKKTGGY------VNKFDNQMFFFGYAKMFCN--RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            W+  + K R  +K  ++   I YPE + D+    I E+   +  +  ++F N + ++ F+ K  L  +      NE+ +G  + NA+Y    NQI  P GI+Q P F L+ +    +  IG +IGHEI HGFD  G +FD  GNL D     S + FK+++ C +++Y   +++L GG        LGENIADN  +     +YM++ K  G       ++    Q+FF  +A+++C   RP    N+ I TD+HSP K+R++G   N + F  AY C+  + +  + KCH+W
Sbjct:  416 WMDDATKGRARDKAFAIVERIGYPEFIVDKNDPKIDEEYADLAYSTTEYFANTLASLAFDSKRRLARINTAVDKNEWISGAAVVNAFYSSSYNQIVFPAGILQPPFFGLDQAMSLNFGGIGMVIGHEIIHGFDDSGRNFDKDGNLVDWWSAESAKNFKQKSQCIIDQYGNFQWDLAGGQNLSGINTLGENIADNGGIRQAYEAYMAWVKDNGEELPLPGLHLSHQQLFFLNFAQVWCGDYRPEYASNS-IKTDVHSPGKFRVIGSLQNFEKFSEAYQCKASDAMNPRSKCHVW 707          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004622.1 (pep scaffold:Pmarinus_7.0:GL480748:697:25272:-1 gene:ENSPMAG00000004207.1 transcript:ENSPMAT00000004622.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 124.02 bits (310), Expect = 2.147e-30
Identity = 84/332 (25.30%), Postives = 160/332 (48.19%), Query Frame = 1
Query: 1132 RENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF----WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQR-NQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDS-MGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALE---ISYMSFKKTGG------YVNKFDNQMFFFGYAKMFCNRPRKDGNTRI---LTDLHSPDKYRILGPTSNSKTFESAYHC 2058
            R  FC+ LA++    +L  +++     + +      +  + + +NL+   K +     W+    +    EK  +++  +   + + D   + +  ++ K+ +  FF  M+N   +  +  ++S+L   +        ++A+Y ++  N + +P GI+Q P +Q       KY+ IG +IGHE+ HGFD+  G  ++ +G  ++    T+  +FK RT C   +Y+ Y      + G   LGENIADN  L    ++Y  +++  G      Y+N  + Q FF  +A+++C+  ++     I   L+D HSP   R+ G  SNS  F  A+ C
Sbjct:   92 RWEFCMDLADKSLAYALGEIFA-----MKEITAKRKEDVKKMIDNLKHAFKDNLDHLPWMDNKTRLAAKEKAKNIQSAVGEDDYMEDVSNVDMFYENFKVVEGRFFETMVNFYNYTSRRTIRSMLATSMQWRAPAQTVDAFYYYESLNTMYIPAGIMQEPFYQDVYPMFLKYAGIGTVIGHELCHGFDNKAGSEYNVEGKQENWWENTTHNEFKLRTHCMEVQYSNYTWKERPINGTQTLGENIADNGGLHTALLAYARWEEQHGKEEPLPYLNLTNKQAFFVWFAQLWCSMEKESVEVEIEDALSDSHSPAAVRVRGMVSNSPAFAEAFTC 418          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000164.1 (pep scaffold:Pmarinus_7.0:GL480158:21651:32008:-1 gene:ENSPMAG00000000145.1 transcript:ENSPMAT00000000164.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 115.161 bits (287), Expect = 3.037e-28
Identity = 75/304 (24.67%), Postives = 134/304 (44.08%), Query Frame = 1
Query: 1258 TENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNE------YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLE-------LGENIADNTALEISYMSFKKTG--------------GYVNKFDNQMFFFGYAKMFCNRPRKDGNTR--ILTDLHSPDKYRILGPTSNSKTFESAYHC 2058
             E++  +I+++F        W+ G  +    EK  S++  + YP+ + +  F+     ++ ++    F N +   +   +  L+  L+ P++              NAYY  + N + +P  + Q P+F  +      + KIG +IGHE++H FD  G  FD +G ++      SL  FK+R+ C VE Y  +   G  E       L  ++AD   L  ++     TG                 N  D Q+FF  +++++C+    +   R  +L D HSP + R L   SNS  F + ++C
Sbjct:    1 AEDIVTRIRNAFVSNLDSVAWMDGKTRAAAKEKSMSIKFQVGYPQGMLEPGFLDRLYANVTVS-GSLFENTLELYR-TRRETLQQQLSVPVDNNDNNRWSMNPQTANAYYSPEENTVVLPAALFQPPLFHGDFPMAVNFGKIGVVIGHEVTHAFDDQGRRFDGQGRMRTWWSSASLAAFKQRSDCLVELYERWAAGGVAEAFRELLGLKGDVADLGGLLTAFRVRSATGTSWWTEERGEEAFLPVRNLTDRQIFFTAFSQVWCSAETAEDRRRQLLLRDTHSPARLRTLASLSNSAEFAATFNC 302          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Match: mmel1 (membrane metallo-endopeptidase-like 1 [Source:ZFIN;Acc:ZDB-GENE-101112-2])

HSP 1 Score: 97.8265 bits (242), Expect = 2.821e-21
Identity = 127/593 (21.42%), Postives = 242/593 (40.81%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQNRKPSLFEE----------MTNSMFNIGKRLISQS----NENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEF----IAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQV-------YLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLD--ENGALNIMKFEYMIDKLWGESSELG-----FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTC----KVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENF--CLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKIN--KNDFFNNMINAVKFNYKNNLKSLL-NGPLNEYFTG-FEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIA 1833
             +PC +F  F CG   K  +  E          + + +  + KRL+ ++    + +  TK +  Y SC++   I+ +      +  ++     +A      T G   + + +  L F  S+     +  +  + +  D+  +   I +P +       Y  +    +   T L  + ++    +I+    + + +D  +     + + E  I +    +         F ++TL  L++  P   ++  W ++ N      LK V I++ +++ ++ +     + L   LNS      V NY  W  I    E++ +    ++E +           A+T K       ++L R  +  C+   N   P ++ +LY          +  +  + + L E     +    W+    + R  EK  ++   + Y + + D     + E+   +N  ++  F N +  ++F  KN LK L       E+  G   INA+Y   +NQI  P GI+Q P F L  +    +  IG +IGHEI+HGFD+ G  FD +GNL D     S   F  R+ C V +Y+ Y     L  G+N++
Sbjct:   12 ANPCDNFYEFACGGWPKKQVIPEDSGYYGTFHVLDDHLEIVLKRLLEEAAGSGDRDAVTKAKRLYLSCMDEEAIEERDSEPLLWLLEDVLEWPVATVDWNSTYGS--QWRLEEVLAFMTSRYGNRVIIDVGIASDVNDSKSSAIYIDQPSLGLPTRDFYFDKGYYSQVRDTYL--RAMIAVATIIRADKNITDDIDFVQEQMEGVFRLEMEIAEAITPAENRTDVTKLFNRMTLLQLQQEFPLNGFN--WTLFINEV----LKTVDIEVEASEEILVSAPEYLEQLSDILNSHPPSD-VHNYVVWILI---TEVIGSLSHKYQEAI-----------AETQKML---YGVLLARARWRHCVDYVNTALPSAVGALYVLDAF-PRHGKTKVEMMIERLREAFIHTLDEMTWMDDRTRARAREKALAITTQMGYADYIVDGNNPRLDEEYADLNYEEDVHFENTLQDLEFAVKNELKRLRRTTSKQEWDIGPATINAFYHPSKNQIVFPAGILQPPFFGLGQAMSLNFGGIGMVIGHEITHGFDNFGRKFDKEGNLVDWWTAESDEDFDSRSRCLVSQYSSYTW--DLASGQNVS 573          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO41501 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4D9])

HSP 1 Score: 179.874 bits (455), Expect = 3.422e-47
Identity = 178/700 (25.43%), Postives = 305/700 (43.57%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQ----------NRKPSLFEEMTNSMFNIGKRLISQ----SNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQ-TLGRTIK------EQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVL-GESLDENGAL---NIMKFEYMIDKLWGESSELG-----FEQITLKDLRRFCPAFDWDIIWKIYYN---VADLAKLKPVVIQMTS-----AKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSML-ELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLT-GSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNE--YFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLP-----GGLELGENIADNTALEISYMSFKK-----------TGGYVNKFDNQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            V+PC+DF ++ CG+          N K S F ++        K++  +    SN +   K+R++Y SC N + I+ +     K    + I+       T G T        EQ  S +   KS P F+ +F  A   NS    +NI QI +  + L       +N++   +K+    + ++K A +L G + D    +    I +FE  + +++     L      + ++T++DL++  PA    I W  Y N      +   +PVV+   +     +  VI+T +            RI+ NY  W  I  +  EL K +R         E  L         +   P  K  +T+ +  L  A  +  L +       VK   +Q         ++ E     + +  W+  G+      EK++S+   I YP+ + D   +  +  ++ I     F N +NA +F ++  ++        +  + T  ++NAYY    N I  P GI+Q P F         Y  +G ++GHE++HGFDS G  FD  GNL+      S+  F+E  SC VE+Y+ + +      G   L ENIADN  L +++ + ++            G  +++  +Q+FF G+A+++C+   K+  +  +LTD HSPD+ R+    SNS+ F  AY C     +   KKC +W
Sbjct:   56 VNPCRDFYQYACGKWLKDSVVPAGNSKWSAFHQVAEQNLRTLKKIFDRDDFASNGDIFRKVRDYYSSCTNKSIIEERDAAPLK----KLISDVGSWSVTGGHTWTAETWNFEQALSLMHKLKSTPLFY-MFVAADDKNS---SQNIIQIQQAGITLSDREYYTRNESDKVVKKY--KEFMVKIATLLNGATADSTTGILMDEIFQFEKKLAEIYEPKERLRHSDKIYHKMTVEDLQQLAPA----IPWMDYMNNLFSTPVGHDEPVVVYTPTFLKSMSDLVIRTDR------------RILANYMVWHLIKPLTTELSKPYR---------EAALDLMRVEMGVESGAPTWKSCVTKTDTVLGYATGH--LYVKQHDGKDVKEKAKQVIQ------SIKEAFISNLPTVTWMDEGTKTKARGEKMESVLDLIGYPDWIMDVAQLNAYYVNLVITPEMSFENHLNARRFVHQQTMEKRGKAVDRKEWHMTPVDVNAYYSLPNNYIAFPSGILQRPFFDPEFPQAMNYGAVGMVMGHELTHGFDSKGRLFDKNGNLESWWKNQSVEAFEEHVSCMVEQYSNFTVADVKVDGKQTLDENIADNGGLRLAFQAHRQWDKENEKQPRLPGLELSR--DQLFFLGFAQLWCSSSTKNSMHHPLLTDSHSPDRIRVHAAVSNSEQFAEAYDCPLDTPMNPAKKCRVW 710          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO35107 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMH5])

HSP 1 Score: 151.369 bits (381), Expect = 6.388e-38
Identity = 89/291 (30.58%), Postives = 151/291 (51.89%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSF------------KKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTD-LHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            W+    +    EK +++R NI YP+ + ++  + +    ++++K  +F N     KF  + N+  L   P+++         +NAYY    N+I  P GI+Q P ++ +  N   Y  IG ++GHEI+HGFD  G  F+  GNL       S+  FK++T C V++Y+ Y   G    GL+ LGENIADN  ++ S+ ++            K+  G      +Q+FF  +A+++C+  R +   R + + +HSP K R++G  SNS  F  A+ C   +++  K KC +W
Sbjct:  383 WMDEKTRKVAKEKAEAIRENIGYPDFIKNKTALELEYSGVRVDKTKYFWNQYERRKFYNQKNIDEL-GKPVDKTKWSMNPPTVNAYYSSTDNKIVFPAGILQDPFYEGDHPNSLNYGGIGMVVGHEITHGFDDNGRKFNKDGNLLTWWTNNSIEAFKKKTDCLVKQYSSYEFHGKKLNGLQTLGENIADNGGIKQSFQAYQKWKKDNNVEEEKRLPGLEKLSHDQLFFLSFAQIWCSAYRPEAAIRAIENGVHSPGKLRVIGSLSNSNEFAEAWKCPVGSRMNPKDKCAVW 672          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO49684 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFZ0])

HSP 1 Score: 150.214 bits (378), Expect = 1.342e-37
Identity = 176/703 (25.04%), Postives = 303/703 (43.10%), Query Frame = 1
Query:  187 PCKDFNRFVCGQ--NRKP--------SLFEEMTNSMFNIGKRLISQSN------ENYS-TKLRNFYKSCINLNRIKR----------KSLNSF-----KYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLL---KEKNQTKLEIKRILINKQLIKWANVLGESLDENGALN-IMKFEYMIDKLWGESSELG---FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNS--KESFR-IVENYFKWTTIFSMLELV-KTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHE-KSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFE--INAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNL-KDLLGKTSLRKFKERTSCFVEKY------NEYNLPGGLELGENIADNTALEISYMSF----KKTGGYVN-----KFDN-QMFFFGYAKMFCNRPR-KDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            PCKDF +F CG    + P        S F +++  + +  + L+   +      EN +  K ++FY+SC++   I+R          + L S+     K W +E    Y   + L          Q  ++ + P     F++  + +  ++ +++ ++ +  + L + +     E   T +E         + K A +LG   +    +  I+ FE  +  +   + +     + +I L  L +  P F W    +  +  A           +T A  V+ T       +N   KE+ + ++ NY  W  I   + L+ K FR   +    F + ++        K++EP       R   C  + N    + L +LY     N     +  + I   + +  + ++K   W+       + +K D++R  I Y   V  R  IL    KS+KI K  FF+N +N  K+     +  L      E +  F   INA Y F  N+I    G ++     L ++    Y  +G IIGHE++HGFD+ G  FD  G++ ++   K+SL  FK R  C  ++Y      N+Y L G + L ENIADN   ++SY ++    K  G         K+ N Q+FF GYA+ +C+  R K      L+D+HSP K+R++G  SN + F  A+ C   + +  KKKC +W
Sbjct:   24 PCKDFFKFSCGNWVRKHPIPRSYNDFSTFTKVSKDIEDQLRELLETPSYIETLPENQALRKAKDFYRSCMDTKTIERLGTRPLMKLIRQLGSWSLCNDKSWNKEKWDAYDVLRKL----------QSTYYPASP----FFSVEVTNDHLNSTRHLIKVDQSGLSLQREIYFKHPEMVDTYVEY--------MAKVATLLGIKGNATKEMRKIVDFETKLANITTSAEDKADGIYRRIKLHHLIKLVPGFPWLKHMQAIFRGA----------HVTDADVVLATPSTYLSKMNDIIKETPKELLSNYVVWQMIRDKISLLSKPFR---KARAVFNHKISG------VKEQEP-------RWRTCTSITNDNLGVPLGTLYVRKYFNESTVGKIQLMIQ-EIKDTFKERVKEHEWIDDKTTQYVFQKADALRSKIGYANYVL-RPIILKKRFKSLKIGKKTFFSNNVNVDKWVRHRLVGKLRKAVDKEKWPMFPQTINAMYQFYENEIGGGRGCLRRVFLALALALSLSYGAVGSIIGHEMTHGFDNTGRKFDKNGDIVQEWWSKSSLTNFKNRAQCIADQYSKFKIQNKYPLSGVVTLDENIADNGGTKLSYNAYHRWLKDNGNQEQVLPGLKYTNEQLFFIGYAQEYCSHARPKTEYIASLSDIHSPPKFRVIGTLSNMEEFSDAFKCPPGSPMNPKKKCEVW 676          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO31998 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWD9])

HSP 1 Score: 139.043 bits (349), Expect = 5.643e-36
Identity = 86/288 (29.86%), Postives = 145/288 (50.35%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPG----GLE-LGENIADNTALEISYMSF------------KKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTD-LHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            W+    +    EK +++R NI YP+ + ++  + +    +++    F  +  N +      N +  +N P         +NAYY    N+I  P GI+Q P ++ +  N   Y  IG ++GHEI+HGFD  G  F+  GNL       S+  FK++T C V++Y+ Y   G    GL+ LGENIADN  ++ S+ ++            K+  G      +Q+FF  +A+++C+  R +   R + + +HSP K R++G  SNS  F  A+ C   +++  K KC +W
Sbjct:   63 WMDEKTRKVAKEKAEAIRENIGYPDFIKNKTALELEYSGVRVVYTYFRQHSENLLSVIV--NFRWSMNPPT--------VNAYYSSTDNKIVFPAGILQDPFYEGDHPNSLNYGGIGMVVGHEITHGFDDNGRKFNKDGNLLTWWTNNSIEAFKKKTDCLVKQYSSYEFHGKKLNGLQTLGENIADNGGIKQSFQAYQKWKKDNNVEEEKRLPGLEKLSHDQLFFLSFAQIWCSAYRPEAAIRAIENGVHSPGKLRVIGSLSNSNEFAEAWKCPVGSRMNPKDKCAVW 340          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Match: EDO37487 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFL4])

HSP 1 Score: 137.502 bits (345), Expect = 1.064e-34
Identity = 88/293 (30.03%), Postives = 146/293 (49.83%), Query Frame = 1
Query: 1279 IKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEY---FTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK------KTGGYVNKFD---NQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + S  W+ G+ K++  EK  ++  +I YP+ + D   +    +++    +  F N ++ +KF  + +L + L  P+N         ++N YY  ++N+I    GI+Q P F         Y  +G +IGHEI+HGFD  G  FD  GNL +     +   F  +T C V +YN Y     NL G   L ENIADN  ++++Y  +K         G +       +Q+F+ G+A+ +C+    +    +I TD HS  KYR++GP  N   F   + C++ +K+   KKC +W
Sbjct:  135 VDSLPWMDGATKEKAKEKAIAIHESIGYPDYIKDPAKLEAKIQNLTFG-DRLFENTLSLIKFTVQTDL-AQLKKPVNREKWELGPSQVNGYYNSRQNRIVFLAGILQPPFFNPLYPKYLNYGGLGMVIGHEITHGFDGSGRMFDKDGNLNNWWSSEASMNFNSKTQCLVHQYNTYSAFGKNLNGSQTLNENIADNGGIKMAYEGYKAWARENSAEGALPGLGLSVDQLFYVGFARPWCSIYTEQTAILQINTDSHSYPKYRVIGPLQNDPLFSEVFKCKKNSKMNPAKKCAVW 425          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:101164289])

HSP 1 Score: 187.193 bits (474), Expect = 7.190e-49
Identity = 177/723 (24.48%), Postives = 318/723 (43.98%), Query Frame = 1
Query:   94 SLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCG----QNRKP------SLFEEMTNSMFNIGKRLISQSNENYST----KLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF----FKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL----NIMKFEYMIDKL-----WGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
             L L    +T+ S+I+       ++  R VDPC+DF +F CG    +N  P      S F  +      + K L+     N S+    K +++Y SC+N  RI+            + I K       G   K+ F   L+     +++QP     F++  S +  ++  N+ Q+ +  ++L  S     N+T  E         +++   +LG   +++  L     I++FE  +  +          E  + ++T+ +L+   PA DW        +  +L   +PVV+    A+  ++  +V E  L +K    ++ NY  WT +  S+  L + F +  +  L         S   T K   P       R   C+   +     +L +L+  +  +   +          + E +  +I+S+F        W+    +    EK DS+   I +PE + D K +       +++ + FF NM+N   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D +GNL+     +S+  F+ RT C +E+YN Y     ++ G   LGENIADN  L+ +Y +++         K    VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP +YR++G  +NS  F   + C     +   K C +W
Sbjct:   90 GLCLSEACITVASQIV-------EAMDRSVDPCQDFYQFACGGWMRKNPLPDGRSRWSTFNSIWGQNQALLKHLLENGTFNGSSEAERKTQSYYLSCLNTQRIEELGAQPLI----DLITKIGGWNMTGPWDKDNFMEVLKVVSGPYRAQP----FFSVGVSADPKNSNSNVVQVDQSGLFL-PSRDYYLNKTANEKVLAAYLDYMVELGMLLGG--EKSSTLVQMQQILEFETALANITVPQDQRRDEEKIYHKVTIAELQALAPAVDWLEFLTSSLSPLELNDTEPVVLY---AREYLQ--QVSE--LINKTDRSLLNNYMMWTLVQKSVATLDQRFENAQDRLLE--------SLYGTKKSCTP-------RWQTCIGNTDDTLGFALGALFVKATFDKLSK---------EIAEEMINEIRSAFKQALDRLSWMDEQTRKAAKEKADSIYDMIGFPEFILDPKELDDVYDGYEVSDDSFFQNMLNFYNFSARVMADQLRKTPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAHDHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNSSVEAFRVRTECMMEQYNRYTVNGEHVNGKQTLGENIADNGGLKAAYHAYQSWIQRNGQEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPRYRVIGTLANSPDFSRHFGCPEGTPMNSGKPCEVW 763          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: ecel1 (endothelin converting enzyme like 1 [Source:NCBI gene;Acc:101160572])

HSP 1 Score: 171.4 bits (433), Expect = 1.285e-43
Identity = 162/699 (23.18%), Postives = 315/699 (45.06%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQNRKPSLFEEMTNS---MFNIG-------KRLI-----SQSNENYSTKLRNFYKSCINLNRIKR-------KSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEF-FKSQPPFHQ--LFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLI-KWANVLGESLDENGALNIMKFEYMIDKLWGESSE-------LGFEQITLKDLRRFCPAFDW-DIIWKIYYNVADLAKLKPVVIQMTS----AKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLN--GPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYN-----LPGGLELGENIADNTALEISYMSFKKTGGYVNKFD------------NQMFFFGYAKMFCNRPRKDG-NTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + PC+DF  F CG   K     E   S   +  IG       +RL+      +S  +   K++ FY+SC+N+ RI +       + L+S   W  + +          +    Q     E  +++Q  +     F+L  +++  ++ +N  +I +  + L +  L    Q +  +K +   K L+ +  ++LG       +  I++ E  +  +     E         + +ITL++L+   P   W  ++ KI+++  + ++ + +V+  T       ++I+T            S R++ NY  W  + ++ E + T          F + + +FS      +++    L L+R   CL   N++F ++L +L+        Q +  + ++ +++  +L L++    W+  + K     K+  M +   YP+ +   + I   E    +N+  +F N++N++KFN K ++K +               +NAYY+  +NQ+  P GI+Q  ++         Y  IG IIGHE++HG+D  G  +D  GNLK    + S RKF+++  C V+ Y+ +      + G L LGENIAD   L+++Y +++K   +V +               Q+ F  +A+ +C + R      ++LTD H+P+ YR++G  S    F   +HC + + +    KC +W
Sbjct:  137 IQPCQDFYSFACGGWLKRHGIPEDKLSYGIITAIGEHNEEKLQRLLLEPIRRRSPNSAERKVKEFYRSCVNIQRIDKLGSEPMTELLDSCGGW--DLVGAPPSAAGWVQEGAPQMPDFDELLYRTQGVYSTAVFFSLTVNVDDKNSSRNAIRIDQEGLTLPERSLY-LGQDEDSVKILAAYKALMERLLSMLGAHNATQKSKEIIQLETRLANITVSEYEDQRKDISTMYNRITLRELQHIAPNLRWKHLLDKIFHD--NFSEDEEIVVLATDYIKKVSNIIRTT-----------SKRVLHNYMLWRIVAALSEHLSTA---------FRSTIHEFSREIDGTEQQ----LELSR--LCLTQTNKHFGMALGALFVQQ-HFSSQSKAKVQELVEDIKHSLDLRLHELDWMDEATKQAARAKLKHMMVMTGYPDFLVKPELI-DQEYGFDVNEKTYFKNILNSIKFNIKLSVKKIHEEVDKTAWLLPPQALNAYYLPNKNQMVFPAGILQPTLYNPEFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRHGNLKQWWTEESYRKFQKKAECIVKLYDNFTVYNQRVNGRLTLGENIADMGGLKLAYSAYQK---WVREHGPERPLPGLKYTHEQLLFIAFAQNWCMKRRSQSIYLQLLTDKHAPEHYRVIGSVSQFDEFSRVFHCPKDSPMNPASKCSVW 799          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: phex (phosphate regulating endopeptidase homolog X-linked [Source:NCBI gene;Acc:101156288])

HSP 1 Score: 165.622 bits (418), Expect = 5.251e-42
Identity = 134/496 (27.02%), Postives = 223/496 (44.96%), Query Frame = 1
Query:  718 KFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVAD-----LAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKI-----KSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNG-PLNEYFTG-FEINAYYIFQRNQINVPMGIIQGPIF-QLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-------NLPGGLELGENIADNTALEISYMSFKK-----TGGY-------VNKFDNQMFFFGYAKMFCNRPRKD-GNTRILTDLHSPDKYRILGPTSNSKTFESAYHC-ERXXXXXXXXXCHLW 2103
            K  +M+      +SE  + + TL  L+R  P FDW    K      D     L+  +PV+++        +  + L   LN+ E  R + NY +W T+FS +    T  S    + Y +       YA+ T         +  R + C+         +   L+ +S       Q+   Q+ + L E +R        K + W+    K + VEK  ++   + YPE + +  ++    K +  ++ D++ N++  +KF  + ++  L    P  E+FT    +NA+Y    NQI  P G +Q P F          Y  IG I+GHE++HGFD+ G  +D  GNL      +S+  F E+T C +++YN Y       N+ G   L ENIADN  +  ++ ++++      GG        V+  +NQ+FF  YA + CN  R +    +I    HSP KYR++G  SN + F+ A+ C E     +  + C +W
Sbjct:  251 KLAHMLIPHENRTSENMYNKFTLSRLQRSLPQFDWMGFVKAVVESRDDPDRDLSSSEPVIVRAP------QYFRELMKLLNTTEP-RTIANYVQWRTVFSRI----TTLSRRFLYRYLD-------YARVTT----GTTSLTPRWDKCVNYVENALGYATGRLFVNSY-----FQEDKKQMMEELIEGIRWAFIDMLQKENGWMDEPTKKKAVEKAHAVMAKVGYPEFILNDTYLNEDLKELDFSEKDYYGNVMQTLKFFAQGDISWLRRSVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFWGQEFPRSLSYGAIGVIVGHELTHGFDNNGRKYDKNGNLDQWWSNSSVTAFTEKTQCMIDQYNSYHWEEAGLNVRGKRTLAENIADNGGIREAFRAYRRWVDDNRGGVEEPLLPGVDFSNNQLFFLSYAHVRCNSYRPEAAREQIQNGAHSPPKYRVIGAMSNYEEFQKAFRCPESSVMNRGSQSCRVW 719          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: ece2b (endothelin-converting enzyme 2 [Source:NCBI gene;Acc:101164289])

HSP 1 Score: 165.622 bits (418), Expect = 9.857e-42
Identity = 123/471 (26.11%), Postives = 218/471 (46.28%), Query Frame = 1
Query:  769 FEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIF-SMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSF--------WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF--TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEY-----NLPGGLELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            + ++T+ +L+   PA DW        +  +L   +PVV+    A+  ++  +V E  L +K    ++ NY  WT +  S+  L + F +  +  L         S   T K   P       R   C+   +     +L +L+  +  +   +          + E +  +I+S+F        W+    +    EK DS+   I +PE + D K +       +++ + FF NM+N   F+ +     L   P  + +  T   +NAYY+  +N I  P GI+Q P +  +      +  IG ++GHE++H FD  G  +D +GNL+     +S+  F+ RT C +E+YN Y     ++ G   LGENIADN  L+ +Y +++         K    VN  ++Q+FF G+A+++C+ R  +  +  ++TD HSP +YR++G  +NS  F   + C     +   K C +W
Sbjct:  350 YHKVTIAELQALAPAVDWLEFLTSSLSPLELNDTEPVVLY---AREYLQ--QVSE--LINKTDRSLLNNYMMWTLVQKSVATLDQRFENAQDRLLE--------SLYGTKKSCTP-------RWQTCIGNTDDTLGFALGALFVKATFDKLSK---------EIAEEMINEIRSAFKQALDRLSWMDEQTRKAAKEKADSIYDMIGFPEFILDPKELDDVYDGYEVSDDSFFQNMLNFYNFSARVMADQLRKTPNKDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAHDHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNSSVEAFRVRTECMMEQYNRYTVNGEHVNGKQTLGENIADNGGLKAAYHAYQSWIQRNGQEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPRYRVIGTLANSPDFSRHFGCPEGTPMNSGKPCEVW 789          
BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Match: MME (membrane metalloendopeptidase [Source:NCBI gene;Acc:101170860])

HSP 1 Score: 155.606 bits (392), Expect = 5.993e-39
Identity = 92/291 (31.62%), Postives = 151/291 (51.89%), Query Frame = 1
Query: 1294 WLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSL-LNGPLNEYFTGFEI-NAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKY--------NEYNLPGGLELGENIADNTALEISYMSFK---KTGGY------VNKFDNQMFFFGYAKMFC--NRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            W+    K    EK  ++R  I Y + + D + +    K +  N   +F N++  +++  K  L+ L +    +E+ TG  + NA+Y   +NQI  P GI+Q P F    +    Y  IG +IGHEI+HGFD  G ++D  G+LKD     S R+F E+++C V++Y        N  +L G   LGENIADN  +  +Y +++   K  G       ++   +Q+FF  +A+++C  +RP +  N+ I  D+HSP K+R+LG   N   F  A+ C + + +     C +W
Sbjct:  354 WMDAETKKAAEEKARAIRERIGYSDTIMDDEHLNNEYKDLSYNAEKYFENILQNLEYVQKKRLRKLRVKVNKDEWVTGAAVVNAFYSASKNQIVFPAGILQPPFFSKGQAKSLNYGGIGMVIGHEITHGFDDNGRNYDKDGDLKDWWTPDSTRRFLEQSNCIVDQYSNFSWELANGLHLNGNNTLGENIADNGGIRQAYQAYRNHVKDHGEEPPLPGIDLSHDQLFFLNFAQVWCGTHRPEQAVNS-IKVDVHSPGKFRVLGSLQNFPEFAKAFSCNKSSYMIPDNVCRVW 643          
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000069765.1 (SMESG000069765.1)

HSP 1 Score: 1340.1 bits (3467), Expect = 0.000e+0
Identity = 679/679 (100.00%), Postives = 679/679 (100.00%), Query Frame = 1
Query:   67 MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNIPQQQQGIIQIFQNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERKNKIKEKKKCHLW
Sbjct:    1 MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVCGQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENFCLQLANQYFPLSLTSLYSSSVKNIPQQQQGIIQIFQNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMSFKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERKNKIKEKKKCHLW 679          
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000025056.1 (SMESG000025056.1)

HSP 1 Score: 195.667 bits (496), Expect = 7.519e-52
Identity = 176/696 (25.29%), Postives = 318/696 (45.69%), Query Frame = 1
Query:  181 VDPCKDFNRFVCGQ----------NRKPSLFEEMTNSMFNIGKRLIS----QSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTI-----KEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL------------NIMKFEYMIDKLWGE-----SSELGFEQITLKDLR-RFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENF--CLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF-TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXCHLW 2103
            V+PC DF++FVCG+          + + S F+ +   +F I K+L+     ++N +  +K    Y SC+NL+RI          +       Y   + L   +     K      +E    + P  ++       NS   + N+ Q+S    +L+      +N+TK E K+IL         +V  + + + G L             I+K E  I K + +       E  + ++TL +++ ++C  F+W  I +    + ++   K + I +T+  +++  C++ + Y + K   RI+ NY  W T++  +  +                  DF   K  K R     ++ T+E +  C+ +   +  L L ++Y  +  N   + Q +  I   L +  +  + S+ W+    +   +EKID+M   I Y + + +  ++    K I+IN   +F N+          N + L   P N    T  E+NA+Y   +N+I  P GI+Q P F+       KY  IG  +GHEI HGFD  G  +DSKG+L+      + + FK ++ CFV++Y++Y++ G        LGENIADN  + ++Y  +K         K    +N   +Q+FF  +A+++CN + ++     IL++ H+P+ YR++G  SN K F  A++C + + +    KC +W
Sbjct:  115 VNPCYDFSQFVCGKWQSEQILPKGSSRYSTFDVVNTDLFKIQKKLLENPEFKTNSDIYSKAVKLYDSCLNLDRINSLGAIPLVTYLNRTFGAYGGWEMLTNDLNPTLDKWDLAKVIEDPMVETPIIRIIVQEDEKNSSRNILNL-QLS----WLLMERQFLQNETKPENKKIL---------DVFKDYMYDVGKLLKIRKEKFEQFNEILKLEIEIAKKYPKEEDQRDPESTYNKMTLSEIQGKYCQQFNWTEIVRRRMKLVNITMSKDIEIIVTNPTNLLDICELFKSYASKK---RILHNYVLWRTVYQRINFLSE----------------DFQRIKD-KFRRVYYGVVGTKERWEHCVSIVQVHMSLILGNMYIKNNFNKQSKPQVLEMINL-LKQKFQNNLLSNVWMDDQTRSHALEKIDTMWPLIGYTDSILNVTYLEETFKDIEINDQTYFENIDMLTNRAMYRNFEKLNKRPENSTIDTPQEVNAFYSPNKNEIIFPAGILQNPFFEPGFPRSLKYGGIGTAMGHEIIHGFDDTGSKYDSKGDLRVWWTDRTRQLFKTKSDCFVKQYSKYSIHGHSINGENTLGENIADNGGVRLTYQVYKDLEKKYGKEKLLPGLNYTHDQLFFITFARLWCNLQTKQSIIIDILSNAHTPNHYRVIGTLSNFKEFAEAFNCPKGSGMNPTDKCMVW 775          
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000025056.1 (SMESG000025056.1)

HSP 1 Score: 191.815 bits (486), Expect = 6.221e-50
Identity = 178/707 (25.18%), Postives = 322/707 (45.54%), Query Frame = 1
Query:  139 LSSSKKDGKSNQRFVDPCKDFNRFVCGQ----------NRKPSLFEEMTNSMFNIGKRLIS----QSNENYSTKLRNFYKSCINLNRIKRKSLNSFKYWYQEFIAKYKERQTLGRTI-----KEQFQSQLEFFKSQPPFHQLFTLATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKWANVLGESLDENGAL------------NIMKFEYMIDKLWGE-----SSELGFEQITLKDLR-RFCPAFDWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRIVENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKRKLILTRENF--CLQLANQYFPLSLTSLYSSSVKNXXXXXXXXXXXXXNLTENLRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIKINKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYF-TGFEINAYYIFQRNQINVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNLKDLLGKTSLRKFKERTSCFVEKYNEYNLPGGL-----ELGENIADNTALEISYMSFK---------KTGGYVNKFDNQMFFFGYAKMFCN-RPRKDGNTRILTDLHSPDKYRILGPTSNSKTFESAYHCERXXXXXXXXXC 2094
            L ++ +  KS    V+PC DF++FVCG+          + + S F+ +   +F I K+L+     ++N +  +K    Y SC+NL+RI          +       Y   + L   +     K      +E    + P  ++       NS   + N+ Q+S    +L+      +N+TK E K+IL         +V  + + + G L             I+K E  I K + +       E  + ++TL +++ ++C  F+W  I +    + ++   K + I +T+  +++  C++ + Y + K   RI+ NY  W T++  +  +                  DF   K  K R     ++ T+E +  C+ +   +  L L ++Y  +  N   + Q +  I   L +  +  + S+ W+    +   +EKID+M   I Y + + +  ++    K I+IN   +F N+          N + L   P N    T  E+NA+Y   +N+I  P GI+Q P F+       KY  IG  +GHEI HGFD  G  +DSKG+L+      + + FK ++ CFV++Y++Y++ G        LGENIADN  + ++Y  +K         K    +N   +Q+FF  +A+++CN + ++     IL++ H+P+ YR++G  SN K F  A++C + + +    KC
Sbjct:  101 LQAAVEIRKSLNTSVNPCYDFSQFVCGKWQSEQILPKGSSRYSTFDVVNTDLFKIQKKLLENPEFKTNSDIYSKAVKLYDSCLNLDRINSLGAIPLVTYLNRTFGAYGGWEMLTNDLNPTLDKWDLAKVIEDPMVETPIIRIIVQEDEKNSSRNILNL-QLS----WLLMERQFLQNETKPENKKIL---------DVFKDYMYDVGKLLKIRKEKFEQFNEILKLEIEIAKKYPKEEDQRDPESTYNKMTLSEIQGKYCQQFNWTEIVRRRMKLVNITMSKDIEIIVTNPTNLLDICELFKSYASKK---RILHNYVLWRTVYQRINFLSE----------------DFQRIKD-KFRRVYYGVVGTKERWEHCVSIVQVHMSLILGNMYIKNNFNKQSKPQVLEMINL-LKQKFQNNLLSNVWMDDQTRSHALEKIDTMWPLIGYTDSILNVTYLEETFKDIEINDQTYFENIDMLTNRAMYRNFEKLNKRPENSTIDTPQEVNAFYSPNKNEIIFPAGILQNPFFEPGFPRSLKYGGIGTAMGHEIIHGFDDTGSKYDSKGDLRVWWTDRTRQLFKTKSDCFVKQYSKYSIHGHSINGENTLGENIADNGGVRLTYQVYKDLEKKYGKEKLLPGLNYTHDQLFFITFARLWCNLQTKQSIIIDILSNAHTPNHYRVIGTLSNFKEFAEAFNCPKGSGMNPTDKC 772          
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000001289.1 (SMESG000001289.1)

HSP 1 Score: 166.777 bits (421), Expect = 1.515e-47
Identity = 90/133 (67.67%), Postives = 106/133 (79.70%), Query Frame = 1
Query: 2284 IWRKNLIFIITEMEPLQILQTELAHARKTSENFYDQIVKLSREIQQTKATWVEPRKAKRIYQRLTAAQKVWMEEKQLNQSLKVQIKGLEVALAASQEKTAVTYPLVFTPAQLAYRXXXXXXXXXXXXSSHRPG 2682
            I    LIF++T+ME L+I Q EL HARKT++NFY+QI++LS EIQ TK  W+EPRK K +YQ LTAAQK W +EKQLNQSL++QIKGLEVAL+A QE  AVTY LVF PAQLAYRE  ATP  TP TSS+RPG
Sbjct:    5 IGSPELIFVVTQMESLKIPQKELDHARKTNKNFYEQIIQLSTEIQPTKTAWMEPRKTKALYQMLTAAQKGWADEKQLNQSLRMQIKGLEVALSACQEGAAVTYTLVFAPAQLAYRETVATPKTTPATSSYRPG 137          
BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Match: SMESG000019730.1 (SMESG000019730.1)

HSP 1 Score: 164.466 bits (415), Expect = 3.308e-47
Identity = 92/120 (76.67%), Postives = 104/120 (86.67%), Query Frame = 1
Query: 2320 MEPLQILQTELAHARKTSENFYDQIVKLSREIQQTKATWVEPRKAKRIYQRLTAAQKVWMEEKQLNQSLKVQIKGLEVALAASQEKTAVTYPLVFTPAQLAYRXXXXXXXXXXXXSSHRP 2679
            ME  +ILQ EL HA+  ++ FY+QI++LS+E+QQTKATWVEPRKAKRI+QRLTAAQK WMEEK+ N+SLKVQIK LEVALAASQE TAVTYPLVF PAQLAYRE AAT T TP TSSHRP
Sbjct:    1 MESQRILQKELEHAKAVNKVFYEQILQLSKEVQQTKATWVEPRKAKRIFQRLTAAQKGWMEEKKQNRSLKVQIKELEVALAASQEGTAVTYPLVFAPAQLAYRETAATLTTTPATSSHRP 120          
The following BLAST results are available for this feature:
BLAST of Endothelin converting enzyme 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ECE27.208e-4623.61endothelin converting enzyme 2 [Source:HGNC Symbol... [more]
ECE29.080e-4623.61endothelin converting enzyme 2 [Source:HGNC Symbol... [more]
ECE21.363e-4523.61endothelin converting enzyme 2 [Source:HGNC Symbol... [more]
ECE21.939e-4523.61endothelin converting enzyme 2 [Source:HGNC Symbol... [more]
ECEL13.139e-4222.38endothelin converting enzyme like 1 [Source:HGNC S... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nep-22.265e-4424.06Neprilysin-2 [Source:UniProtKB/Swiss-Prot;Acc:O44... [more]
nep-115.127e-4027.76Neprilysin-11 [Source:UniProtKB/Swiss-Prot;Acc:O1... [more]
nep-19.614e-3928.68Neprilysin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q18... [more]
nep-213.299e-3334.80Neprilysin-21 [Source:UniProtKB/Swiss-Prot;Acc:Q2... [more]
nep-213.299e-3334.80Neprilysin-21 [Source:UniProtKB/Swiss-Prot;Acc:Q2... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nep12.019e-4026.91gene:FBgn0029843 transcript:FBtr0343930[more]
Nep12.019e-4026.91gene:FBgn0029843 transcript:FBtr0070873[more]
Nep12.019e-4026.91gene:FBgn0029843 transcript:FBtr0070872[more]
Nep12.019e-4026.91gene:FBgn0029843 transcript:FBtr0340032[more]
Nep35.551e-3828.48gene:FBgn0031081 transcript:FBtr0307554[more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ece2b1.411e-5024.48endothelin converting enzyme 2b [Source:ZFIN;Acc:Z... [more]
ecel12.252e-4325.52endothelin converting enzyme-like 1 [Source:ZFIN;A... [more]
ece14.747e-4224.75endothelin converting enzyme 1 [Source:ZFIN;Acc:ZD... [more]
ece14.747e-4224.75endothelin converting enzyme 1 [Source:ZFIN;Acc:ZD... [more]
phex6.545e-3926.51phosphate regulating endopeptidase homolog, X-link... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dhdds3.490e-5225.93dehydrodolichyl diphosphate synthase subunit [Sour... [more]
dhdds3.953e-5226.06dehydrodolichyl diphosphate synthase subunit [Sour... [more]
dhdds4.554e-5225.93dehydrodolichyl diphosphate synthase subunit [Sour... [more]
dhdds5.349e-5225.93dehydrodolichyl diphosphate synthase subunit [Sour... [more]
dhdds1.335e-5126.07dehydrodolichyl diphosphate synthase subunit [Sour... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ece22.823e-4724.86endothelin converting enzyme 2 [Source:MGI Symbol;... [more]
Ece23.009e-4724.86endothelin converting enzyme 2 [Source:MGI Symbol;... [more]
Gm493336.129e-4724.86predicted gene, 49333 [Source:MGI Symbol;Acc:MGI:6... [more]
Gm493338.408e-4724.86predicted gene, 49333 [Source:MGI Symbol;Acc:MGI:6... [more]
Ece15.622e-4623.26endothelin converting enzyme 1 [Source:MGI Symbol;... [more]
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BLAST of Endothelin converting enzyme 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P42891|ECE1_BOVIN9.376e-4924.17Endothelin-converting enzyme 1 OS=Bos taurus OX=99... [more]
sp|B2RQR8|ECE2_MOUSE1.975e-4624.86Endothelin-converting enzyme 2 OS=Mus musculus OX=... [more]
sp|P42893|ECE1_RAT2.978e-4624.12Endothelin-converting enzyme 1 OS=Rattus norvegicu... [more]
sp|P0DPD9|EFCE2_MOUSE4.287e-4624.86EEF1AKMT4-ECE2 readthrough transcript protein OS=M... [more]
sp|F1N476|ECE2_BOVIN3.231e-4523.47Endothelin-converting enzyme 2 OS=Bos taurus OX=99... [more]
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BLAST of Endothelin converting enzyme 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A336KGD21.531e-5025.21CSON003355 protein OS=Culicoides sonorensis OX=179... [more]
W8BVC83.975e-5025.99Membrane metallo-endopeptidase-like 1 OS=Ceratitis... [more]
Q17AS15.075e-4926.06AAEL005207-PA OS=Aedes aegypti OX=7159 GN=5566104 ... [more]
F7E0095.479e-4925.93Dehydrodolichyl diphosphate synthase subunit OS=Xe... [more]
A0A0B2W0805.928e-4924.36Endothelin-converting enzyme 1 OS=Toxocara canis O... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ece2b5.683e-5225.48endothelin-converting enzyme 2 [Source:NCBI gene;A... [more]
ece2b6.429e-5225.48endothelin-converting enzyme 2 [Source:NCBI gene;A... [more]
ece2b1.072e-5125.48endothelin-converting enzyme 2 [Source:NCBI gene;A... [more]
ece2b2.009e-4131.36endothelin-converting enzyme 2 [Source:NCBI gene;A... [more]
ece12.199e-4124.17endothelin converting enzyme 1 [Source:ZFIN;Acc:ZD... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ecel13.861e-4227.51endothelin converting enzyme-like 1 [Source:ZFIN;A... [more]
mmel11.187e-4032.76membrane metallo-endopeptidase-like 1 [Source:ZFIN... [more]
ENSPMAT00000004622.12.147e-3025.30pep scaffold:Pmarinus_7.0:GL480748:697:25272:-1 ge... [more]
ENSPMAT00000000164.13.037e-2824.67pep scaffold:Pmarinus_7.0:GL480158:21651:32008:-1 ... [more]
mmel12.821e-2121.42membrane metallo-endopeptidase-like 1 [Source:ZFIN... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO415013.422e-4725.43Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO351076.388e-3830.58Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO496841.342e-3725.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319985.643e-3629.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374871.064e-3430.03Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Endothelin converting enzyme 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ece2b7.190e-4924.48endothelin-converting enzyme 2 [Source:NCBI gene;A... [more]
ecel11.285e-4323.18endothelin converting enzyme like 1 [Source:NCBI g... [more]
phex5.251e-4227.02phosphate regulating endopeptidase homolog X-linke... [more]
ece2b9.857e-4226.11endothelin-converting enzyme 2 [Source:NCBI gene;A... [more]
MME5.993e-3931.62membrane metalloendopeptidase [Source:NCBI gene;Ac... [more]
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BLAST of Endothelin converting enzyme 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000069765.10.000e+0100.00SMESG000069765.1[more]
SMESG000025056.17.519e-5225.29SMESG000025056.1[more]
SMESG000025056.16.221e-5025.18SMESG000025056.1[more]
SMESG000001289.11.515e-4767.67SMESG000001289.1[more]
SMESG000019730.13.308e-4776.67SMESG000019730.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30002040 ID=SMED30002040|Name=Endothelin converting enzyme 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2849bp
CTCATTAATGCCAAAATGTTTATATAACCCTAATTGTGTTTACTTTCATT
TCATTCCTGAACAAAAATGTTCAAATCTTACAATGAATTTCTTTCACTAT
TTTTGATTTTGCTAATTGTTACAATTGGCTCAAAGATTTTGTCGTCATCC
AAGAAAGATGGGAAATCTAACCAAAGATTTGTTGATCCTTGTAAAGACTT
TAATAGATTCGTTTGTGGTCAAAATAGGAAGCCTAGTCTTTTTGAAGAAA
TGACAAACTCCATGTTTAATATTGGTAAAAGATTGATATCTCAATCCAAT
GAAAATTACTCTACAAAACTGCGAAACTTCTACAAATCTTGCATCAACCT
CAACCGAATCAAAAGAAAGTCTTTGAATTCTTTTAAGTATTGGTACCAAG
AATTTATTGCCAAGTACAAAGAACGTCAAACGCTTGGGAGAACAATAAAG
GAACAATTCCAAAGTCAACTTGAATTTTTTAAAAGCCAACCACCTTTTCA
TCAGTTATTTACACTGGCAACATCAATAAACTCATTTGACACAGTGAAAA
ACATTCCTCAGATATCTCGACCGCAAGTTTATCTTATACAAAGTTTATTA
AAGGAGAAAAATCAAACGAAATTAGAAATAAAACGGATTCTAATAAATAA
ACAGTTAATAAAATGGGCAAATGTTTTAGGCGAATCACTTGACGAAAACG
GCGCCTTGAACATAATGAAGTTTGAATATATGATTGATAAGCTATGGGGC
GAATCATCAGAATTGGGATTTGAGCAAATAACGCTCAAAGATTTGAGGAG
GTTTTGTCCAGCTTTTGACTGGGACATAATCTGGAAAATTTACTATAATG
TTGCTGATCTAGCAAAATTGAAACCTGTAGTTATTCAAATGACATCTGCA
AAATCTGTTATAAAAACTTGCAAAGTTTTAGAATATTATTTGAATTCAAA
AGAGAGTTTCCGTATTGTAGAAAACTATTTTAAATGGACCACCATTTTTT
CGATGCTAGAACTTGTCAAAACTTTCCGTTCGCATCACGAAGAGCATTTG
TATTTTGAAAATATTTTAACTGACTTTTCGTATGCAAAAACAACTAAACA
ACGAGAACCAAAAAGGAAGCTGATCCTGACCAGAGAAAACTTTTGTTTGC
AACTTGCGAACCAGTATTTCCCGTTATCCCTCACGTCATTGTACTCATCG
TCAGTGAAAAATATCCCACAACAACAACAGGGTATCATTCAAATATTTCA
GAATCTCACTGAAAATTTGAGGTTAAAAATTAAAAGTTCTTTCTGGCTCA
CTGGTTCAGACAAGGACAGACTTGTGGAGAAAATAGATTCGATGAGAATT
AATATTTTTTATCCTGAAGTTGTAGCAGATAGGAAATTCATTTTAATTCA
CGAAAAATCGATAAAAATTAACAAAAATGATTTTTTCAATAACATGATAA
ATGCTGTCAAGTTTAATTACAAAAACAATCTAAAATCATTACTAAATGGT
CCTCTAAATGAATATTTCACCGGGTTTGAAATAAATGCATATTACATCTT
TCAAAGGAATCAAATTAATGTGCCCATGGGCATCATTCAAGGTCCAATAT
TTCAGCTTAATATGAGTAACGTTGAAAAATACAGTAAAATTGGGTTTATA
ATTGGTCATGAAATTTCACACGGATTTGATTCTATGGGGATTCATTTTGA
TTCAAAAGGAAATCTGAAAGATTTGCTGGGGAAAACATCTTTGCGGAAAT
TTAAAGAACGAACTTCGTGTTTTGTAGAGAAATACAATGAATATAATCTA
CCTGGTGGCTTGGAGTTAGGAGAGAACATTGCAGACAATACGGCACTGGA
AATATCATATATGTCATTCAAGAAAACCGGTGGCTACGTGAATAAATTTG
ATAACCAGATGTTCTTCTTTGGTTATGCGAAAATGTTTTGCAATCGTCCC
AGAAAAGATGGAAATACGAGAATTCTAACGGATTTACATAGCCCAGATAA
ATATAGAATCCTTGGACCCACAAGCAACTCGAAAACGTTTGAGTCGGCGT
ATCATTGTGAGAGGAAAAATAAAATCAAAGAGAAAAAGAAATGTCATTTG
TGGTGACAAATTCATGAAGATTTAAAACAAAAATAATTTTAAAAACATCG
AAAACTTTTTCCCAGTTGATTTGCACGCAATATACAATAAATAATTTGTT
ATTTAAGATTTTCCTTTTTACTCGTTTCATAGTGTAACTTTACAAATTTA
TGTTTAAATCAACTTTGTGCTTAGTAATTTTGGATTTGGCGGAAGAATTT
AATTTTTATCATTACAGAAATGGAACCCCTGCAAATATTACAGACGGAAC
TAGCGCACGCACGGAAAACTAGCGAAAACTTTTACGACCAGATTGTCAAG
CTGTCCCGCGAGATTCAGCAGACAAAAGCCACATGGGTGGAACCAAGGAA
AGCCAAGCGAATCTATCAAAGGCTCACCGCAGCGCAGAAGGTCTGGATGG
AAGAAAAGCAACTAAACCAAAGCCTAAAGGTACAAATCAAGGGACTGGAG
GTCGCATTAGCTGCCAGCCAGGAAAAGACAGCTGTAACCTATCCCCTCGT
GTTTACTCCTGCCCAATTAGCCTACCGAGAGGCGGCAGCCACTCCAACAG
AGACACCAACGACGAGTAGCCATCGTCCGGGACGAAAGGAGCGGGCAAAA
CGCCGAGCCGCTCGAATATTGAAAAACCCGCAACCAACACTTGTTTTATT
TTTAATATATAATTGTCGAATCTACGATAAAATCTACGACATAAAAGGAA
CCTAATAATCTAAAGCGAGCACAAGTCTTCTAACGACAGCTCGTTGGAC
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protein sequence of SMED30002040-orf-1

>SMED30002040-orf-1 ID=SMED30002040-orf-1|Name=SMED30002040-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=680bp
MFKSYNEFLSLFLILLIVTIGSKILSSSKKDGKSNQRFVDPCKDFNRFVC
GQNRKPSLFEEMTNSMFNIGKRLISQSNENYSTKLRNFYKSCINLNRIKR
KSLNSFKYWYQEFIAKYKERQTLGRTIKEQFQSQLEFFKSQPPFHQLFTL
ATSINSFDTVKNIPQISRPQVYLIQSLLKEKNQTKLEIKRILINKQLIKW
ANVLGESLDENGALNIMKFEYMIDKLWGESSELGFEQITLKDLRRFCPAF
DWDIIWKIYYNVADLAKLKPVVIQMTSAKSVIKTCKVLEYYLNSKESFRI
VENYFKWTTIFSMLELVKTFRSHHEEHLYFENILTDFSYAKTTKQREPKR
KLILTRENFCLQLANQYFPLSLTSLYSSSVKNIPQQQQGIIQIFQNLTEN
LRLKIKSSFWLTGSDKDRLVEKIDSMRINIFYPEVVADRKFILIHEKSIK
INKNDFFNNMINAVKFNYKNNLKSLLNGPLNEYFTGFEINAYYIFQRNQI
NVPMGIIQGPIFQLNMSNVEKYSKIGFIIGHEISHGFDSMGIHFDSKGNL
KDLLGKTSLRKFKERTSCFVEKYNEYNLPGGLELGENIADNTALEISYMS
FKKTGGYVNKFDNQMFFFGYAKMFCNRPRKDGNTRILTDLHSPDKYRILG
PTSNSKTFESAYHCERKNKIKEKKKCHLW*
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protein sequence of SMED30002040-orf-2

>SMED30002040-orf-2 ID=SMED30002040-orf-2|Name=SMED30002040-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=162bp
MEPLQILQTELAHARKTSENFYDQIVKLSREIQQTKATWVEPRKAKRIYQ
RLTAAQKVWMEEKQLNQSLKVQIKGLEVALAASQEKTAVTYPLVFTPAQL
AYREAAATPTETPTTSSHRPGRKERAKRRAARILKNPQPTLVLFLIYNCR
IYDKIYDIKGT*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
Vocabulary: INTERPRO
TermDefinition
IPR018497Peptidase_M13_C
IPR024079MetalloPept_cat_dom_sf
IPR008753Peptidase_M13_N
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
GO:0016485protein processing
GO:0016486peptide hormone processing
Vocabulary: molecular function
TermDefinition
GO:0004222metalloendopeptidase activity
GO:0008237metallopeptidase activity
GO:0004175endopeptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
GO:0042803protein homodimerization activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane