Regulator of G-protein signaling

Overview


Name	Regulator of G-protein signaling
Smed ID	SMED30002009
Length (bp)	1868

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Regulator of G-protein signaling (SMED30002009) t-SNE clustered cells

Violin plots show distribution of expression levels for Regulator of G-protein signaling (SMED30002009) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Regulator of G-protein signaling (SMED30002009) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Regulator of G-protein signaling (SMED30002009) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30002009

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 16

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30002009	h1SMcG0016413	SmedASXL_011260	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30002009	h1SMcG0016413	Contig35037	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30002009	h1SMcG0016413	Contig35037	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30002009	h1SMcG0016413	Contig42236	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30002009	h1SMcG0016413	Contig42236	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
nervous system	SMED30002009	h1SMcG0016413	dd_Smed_v4_8648_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30002009	h1SMcG0016413	dd_Smed_v4_8648_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30002009	h1SMcG0016413	dd_Smed_v4_8648_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30002009	h1SMcG0016413	dd_Smed_v4_8648_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30002009	h1SMcG0016413	dd_Smed_v4_8648_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30002009	h1SMcG0016413	dd_Smed_v6_8648_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
head region	SMED30002009	h1SMcG0016413	OX_Smed_1.0.22399	ox_Smed_v2	PMID:24238224 Kao et al., 2013
oocyte	SMED30002009	h1SMcG0016413	Contig13300	newmark_ests	PMID:28434803 Rouhana et al., 2017
oocyte	SMED30002009	h1SMcG0016413	Contig13300	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30002009	h1SMcG0016413	Contig13300	newmark_ests	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30002009	h1SMcG0016413	Contig13300	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Regulator of G-protein signaling vs. Ensembl Human
Match: RGS5 (regulator of G protein signaling 5 [Source:HGNC Symbol;Acc:HGNC:10001])

HSP 1 Score: 151.754 bits (382), Expect = 3.643e-42
Identity = 70/128 (54.69%), Postives = 100/128 (78.12%), Query Frame = 2

Query: 1088 LNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            L+E +Q W +S ++LL + YGLA F  +LKSE+SEEN+EFWIACE++K I +P KMA +A++I ++F+ T+APKEVNID  T+ IT++++  P+ + FDMAQKRI +LME DS  RF+RSE YQ L++
Sbjct:   55 LDEALQ-WRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK 181

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BLAST of Regulator of G-protein signaling vs. Ensembl Human
Match: RGS8 (regulator of G protein signaling 8 [Source:HGNC Symbol;Acc:HGNC:16810])

HSP 1 Score: 150.599 bits (379), Expect = 9.082e-42
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW +SF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ S+A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

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Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW +SF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ S+A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

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Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW +SF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ S+A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

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BLAST of Regulator of G-protein signaling vs. Ensembl Human
Match: RGS3 (regulator of G protein signaling 3 [Source:HGNC Symbol;Acc:HGNC:9999])

HSP 1 Score: 149.443 bits (376), Expect = 1.542e-41
Identity = 79/179 (44.13%), Postives = 114/179 (63.69%), Query Frame = 2

Query:  962 MKEKFNFLRKPGD-PAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIP 1495
            MK K    R+  + P  PP             + +K+++  K  +E+  +W ES E+LL  KYGLA+F  +L++E+SEEN+EFW+ACE+FK + +  KMAS+A+KI  +++  QA KEVN+DS TR+ T +++Q      FD+AQKRI  LME DSY RFLRS++Y  L+   KK S P
Sbjct:    1 MKNKLGIFRRRNESPGAPPAG-----------KADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQ-KKMSPP 167

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BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
Match: rgs-2 (Regulator of G-protein signaling rgs-2 [Source:UniProtKB/Swiss-Prot;Acc:P49808])

HSP 1 Score: 117.087 bits (292), Expect = 2.483e-30
Identity = 54/120 (45.00%), Postives = 83/120 (69.17%), Query Frame = 2

Query: 1109 WNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            W++SFE L+  + G   F ++LK EYS+ENI FW ACEE K   N +K+  +A+ I +DF++  +PKEV++DS+ R+I   ++  P+A+ FD AQ +I +LM+ DSY RFL S +Y+ +M
Sbjct:   33 WSQSFENLMKHRAGQKYFAEFLKGEYSDENILFWQACEELKREKNAEKIEEKARIIYEDFISILSPKEVSLDSRVREIVNTNMGRPSASTFDEAQNQIYTLMQRDSYPRFLASNIYKTVM 152

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
Match: rgs-2 (Regulator of G-protein signaling rgs-2 [Source:UniProtKB/Swiss-Prot;Acc:P49808])

HSP 1 Score: 117.087 bits (292), Expect = 3.872e-30
Identity = 55/125 (44.00%), Postives = 85/125 (68.00%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E +  W++SFE L+  + G   F ++LK EYS+ENI FW ACEE K   N +K+  +A+ I +DF++  +PKEV++DS+ R+I   ++  P+A+ FD AQ +I +LM+ DSY RFL S +Y+ +M
Sbjct:   47 EIVFGWSQSFENLMKHRAGQKYFAEFLKGEYSDENILFWQACEELKREKNAEKIEEKARIIYEDFISILSPKEVSLDSRVREIVNTNMGRPSASTFDEAQNQIYTLMQRDSYPRFLASNIYKTVM 171

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
Match: rgs-2 (Regulator of G-protein signaling rgs-2 [Source:UniProtKB/Swiss-Prot;Acc:P49808])

HSP 1 Score: 116.316 bits (290), Expect = 5.800e-30
Identity = 54/120 (45.00%), Postives = 83/120 (69.17%), Query Frame = 2

Query: 1109 WNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            W++SFE L+  + G   F ++LK EYS+ENI FW ACEE K   N +K+  +A+ I +DF++  +PKEV++DS+ R+I   ++  P+A+ FD AQ +I +LM+ DSY RFL S +Y+ +M
Sbjct:   38 WSQSFENLMKHRAGQKYFAEFLKGEYSDENILFWQACEELKREKNAEKIEEKARIIYEDFISILSPKEVSLDSRVREIVNTNMGRPSASTFDEAQNQIYTLMQRDSYPRFLASNIYKTVM 157

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
Match: rgs-2 (Regulator of G-protein signaling rgs-2 [Source:UniProtKB/Swiss-Prot;Acc:P49808])

HSP 1 Score: 116.316 bits (290), Expect = 6.257e-30
Identity = 54/120 (45.00%), Postives = 83/120 (69.17%), Query Frame = 2

Query: 1109 WNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            W++SFE L+  + G   F ++LK EYS+ENI FW ACEE K   N +K+  +A+ I +DF++  +PKEV++DS+ R+I   ++  P+A+ FD AQ +I +LM+ DSY RFL S +Y+ +M
Sbjct:   40 WSQSFENLMKHRAGQKYFAEFLKGEYSDENILFWQACEELKREKNAEKIEEKARIIYEDFISILSPKEVSLDSRVREIVNTNMGRPSASTFDEAQNQIYTLMQRDSYPRFLASNIYKTVM 159

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BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
Match: rgs-1 (Regulator of G-protein signaling rgs-1 [Source:UniProtKB/Swiss-Prot;Acc:P34295])

HSP 1 Score: 112.849 bits (281), Expect = 2.564e-28
Identity = 57/125 (45.60%), Postives = 80/125 (64.00%), Query Frame = 2

Query: 1085 LLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQ 1459
            L  E +  W +SF+ L++ K G   F ++LKSEYS+ENI FW ACEE K   N +KM  +A+ I +DF++  +PKEV++DSK R+I   ++  P  N F+ AQ +I  LM  DSY RFL S  Y+
Sbjct:   30 LSYEMVYSWQQSFDTLMSFKSGQKCFAEFLKSEYSDENILFWQACEELKREKNSEKMEEKARIIYEDFISILSPKEVSLDSKVREIVNTNMSRPTQNTFEDAQHQIYQLMARDSYPRFLTSIFYR 154

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BLAST of Regulator of G-protein signaling vs. Ensembl Fly
Match: Dhit (gene:FBgn0028743 transcript:FBtr0340279)

HSP 1 Score: 114.39 bits (285), Expect = 4.794e-28
Identity = 50/126 (39.68%), Postives = 86/126 (68.25%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            E+I+ W +SF++L+    G  +F ++L+SE+SEENI FW+ACE+ K   +P+ +  +A+ I +D+++  +P+EV++DS+ R+I   ++  P  + FD AQ +I +LM  DSY RFL S+ ++ L Q
Sbjct:  131 EEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACEDLKKENSPELVEEKARLIYEDYISILSPREVSLDSRVREIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYPRFLNSQKFKTLAQ 256

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BLAST of Regulator of G-protein signaling vs. Ensembl Fly
Match: Dhit (gene:FBgn0028743 transcript:FBtr0301142)

HSP 1 Score: 114.39 bits (285), Expect = 5.322e-28
Identity = 50/126 (39.68%), Postives = 86/126 (68.25%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            E+I+ W +SF++L+    G  +F ++L+SE+SEENI FW+ACE+ K   +P+ +  +A+ I +D+++  +P+EV++DS+ R+I   ++  P  + FD AQ +I +LM  DSY RFL S+ ++ L Q
Sbjct:  134 EEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACEDLKKENSPELVEEKARLIYEDYISILSPREVSLDSRVREIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYPRFLNSQKFKTLAQ 259

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BLAST of Regulator of G-protein signaling vs. Ensembl Fly
Match: loco (gene:FBgn0020278 transcript:FBtr0084275)

HSP 1 Score: 107.842 bits (268), Expect = 6.567e-24
Identity = 50/135 (37.04%), Postives = 84/135 (62.22%), Query Frame = 2

Query: 1109 WNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIPEPVPNS 1513
            W  SFE++L D  G+  F ++LK E+S ENI FW ACE ++ + +     ++A++I    +   +   VN+DS+ R +T E +     ++F  AQK+I SLM+ DSYQRF+RS++Y++ ++  +K    +P+P S
Sbjct:  458 WAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKN---QPLPYS 589

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Fly
Match: loco (gene:FBgn0020278 transcript:FBtr0304669)

HSP 1 Score: 107.457 bits (267), Expect = 7.148e-24
Identity = 50/135 (37.04%), Postives = 84/135 (62.22%), Query Frame = 2

Query: 1109 WNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIPEPVPNS 1513
            W  SFE++L D  G+  F ++LK E+S ENI FW ACE ++ + +     ++A++I    +   +   VN+DS+ R +T E +     ++F  AQK+I SLM+ DSYQRF+RS++Y++ ++  +K    +P+P S
Sbjct:   65 WAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKN---QPLPYS 196

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Fly
Match: loco (gene:FBgn0020278 transcript:FBtr0084276)

HSP 1 Score: 107.457 bits (267), Expect = 7.670e-24
Identity = 50/135 (37.04%), Postives = 84/135 (62.22%), Query Frame = 2

Query: 1109 WNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIPEPVPNS 1513
            W  SFE++L D  G+  F ++LK E+S ENI FW ACE ++ + +     ++A++I    +   +   VN+DS+ R +T E +     ++F  AQK+I SLM+ DSYQRF+RS++Y++ ++  +K    +P+P S
Sbjct:  112 WAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKN---QPLPYS 243

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BLAST of Regulator of G-protein signaling vs. Ensembl Zebrafish
Match: RGS13 (si:ch211-117l17.5 [Source:ZFIN;Acc:ZDB-GENE-110914-230])

HSP 1 Score: 152.14 bits (383), Expect = 8.131e-43
Identity = 70/132 (53.03%), Postives = 98/132 (74.24%), Query Frame = 2

Query: 1082 KLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            +L  E  Q+W++S E+LL  KYGLA F  +LKSE+S+ENIEFW+ CE++KTIT+  KM+S+A+KI + FV  ++PKE+NID +TR+     ++ P A  FD AQK +  LME DSY RFLRSEMY++L++ I
Sbjct:   16 RLSLEDTQQWSQSLERLLGSKYGLATFRTFLKSEFSDENIEFWLTCEDYKTITSSHKMSSKARKIFEQFVEAESPKEINIDYQTREEIKRKMKSPTAQCFDEAQKIVYGLMERDSYPRFLRSEMYKSLLETI 147

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BLAST of Regulator of G-protein signaling vs. Ensembl Zebrafish
Match: BX936311.1 (si:ch211-117l17.5 [Source:NCBI gene;Acc:792554])

HSP 1 Score: 152.525 bits (384), Expect = 8.320e-43
Identity = 70/132 (53.03%), Postives = 98/132 (74.24%), Query Frame = 2

Query: 1082 KLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            +L  E  Q+W++S E+LL  KYGLA F  +LKSE+S+ENIEFW+ CE++KTIT+  KM+S+A+KI + FV  ++PKE+NID +TR+     ++ P A  FD AQK +  LME DSY RFLRSEMY++L++ I
Sbjct:   31 RLSLEDTQQWSQSLERLLGSKYGLATFRTFLKSEFSDENIEFWLTCEDYKTITSSHKMSSKARKIFEQFVEAESPKEINIDYQTREEIKRKMKSPTAQCFDEAQKIVYGLMERDSYPRFLRSEMYKSLLETI 162

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Zebrafish
Match: RGS13 (si:ch211-117l17.5 [Source:ZFIN;Acc:ZDB-GENE-110914-230])

HSP 1 Score: 152.14 bits (383), Expect = 1.949e-42
Identity = 70/132 (53.03%), Postives = 98/132 (74.24%), Query Frame = 2

Query: 1082 KLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            +L  E  Q+W++S E+LL  KYGLA F  +LKSE+S+ENIEFW+ CE++KTIT+  KM+S+A+KI + FV  ++PKE+NID +TR+     ++ P A  FD AQK +  LME DSY RFLRSEMY++L++ I
Sbjct:   45 RLSLEDTQQWSQSLERLLGSKYGLATFRTFLKSEFSDENIEFWLTCEDYKTITSSHKMSSKARKIFEQFVEAESPKEINIDYQTREEIKRKMKSPTAQCFDEAQKIVYGLMERDSYPRFLRSEMYKSLLETI 176

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Zebrafish
Match: rgs8 (regulator of G protein signaling 8 [Source:NCBI gene;Acc:436804])

HSP 1 Score: 147.517 bits (371), Expect = 6.133e-41
Identity = 67/136 (49.26%), Postives = 98/136 (72.06%), Query Frame = 2

Query: 1061 EKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E+  R  KL N+++ RW +SF+ LL++KYGLA F  +LK+E+S+ENIEFW+ACE++K I +P KM S+A KI K+F+   AP+EVNID +TR+ T   +  P  +  +  Q ++ SLME DSY RF+RS++YQ L+
Sbjct:   27 ERTTRYLKLSNDEVTRWADSFDILLSNKYGLAAFRTFLKTEFSDENIEFWLACEDYKKIKSPAKMMSKANKIYKEFIDVHAPREVNIDHRTREETKNRLLEPTPHSLNEVQAKVYSLMEKDSYPRFIRSKIYQDLL 162

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Query: 1061 EKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E+  R  KL N+++ RW +SF+ LL++KYGLA F  +LK+E+S+ENIEFW+ACE++K I +P KM S+A KI K+F+   AP+EVNID +TR+ T   +  P  +  +  Q ++ SLME DSY RF+RS++YQ L+
Sbjct:   27 ERTTRYLKLSNDEVTRWADSFDILLSNKYGLAAFRTFLKTEFSDENIEFWLACEDYKKIKSPAKMMSKANKIYKEFIDVHAPREVNIDHRTREETKNRLLEPTPHSLNEVQAKVYSLMEKDSYPRFIRSKIYQDLL 162

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BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
Match: cipc (CLOCK-interacting pacemaker [Source:Xenbase;Acc:XB-GENE-5806252])

HSP 1 Score: 145.976 bits (367), Expect = 1.388e-39
Identity = 62/137 (45.26%), Postives = 97/137 (70.80%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKA 1486
            + +L  ++ +RW  SF+ LL+ KYG  +F  +L++E+SEEN+EFW+ACEE++   +  K+ ++A  I ++F+  QAP+EVN+D  TR++T  ++ HP  + FD+AQ RI SLME DSY RFLRS+MY  L+   +K+
Sbjct:   78 LKRLTPDEARRWARSFDLLLSHKYGRTMFRAFLQTEFSEENLEFWVACEEYRKTRSLNKLPAKAHHIFQEFIDVQAPREVNLDYPTRELTKRNLLHPTLSCFDLAQLRIHSLMERDSYPRFLRSKMYNDLLSHTQKS 214

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BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
Match: cipc (CLOCK-interacting pacemaker [Source:Xenbase;Acc:XB-GENE-5806252])

HSP 1 Score: 144.05 bits (362), Expect = 1.618e-39
Identity = 62/137 (45.26%), Postives = 97/137 (70.80%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKA 1486
            + +L  ++ +RW  SF+ LL+ KYG  +F  +L++E+SEEN+EFW+ACEE++   +  K+ ++A  I ++F+  QAP+EVN+D  TR++T  ++ HP  + FD+AQ RI SLME DSY RFLRS+MY  L+   +K+
Sbjct:   38 LKRLTPDEARRWARSFDLLLSHKYGRTMFRAFLQTEFSEENLEFWVACEEYRKTRSLNKLPAKAHHIFQEFIDVQAPREVNLDYPTRELTKRNLLHPTLSCFDLAQLRIHSLMERDSYPRFLRSKMYNDLLSHTQKS 174

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BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
Match: fancd2os (FANCD2 opposite strand [Source:Xenbase;Acc:XB-GENE-965507])

HSP 1 Score: 142.51 bits (358), Expect = 2.502e-38
Identity = 62/128 (48.44%), Postives = 95/128 (74.22%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            E+ + W+E+F+ LL  KYG+A F  +LKSE+SEENIEFW+ACE+FK   +P K+ ++A+KI  +F+  +APKE+NID +TR+  ++++Q P+ + F  AQ+R+ SLM  +SY RF++SE YQ L Q +
Sbjct:   80 EEAKSWSETFDDLLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSPHKLTAKAKKIYDEFIEKEAPKEINIDFQTRENIMQTMQEPSHSCFSAAQRRVYSLMVNNSYPRFIQSEFYQELCQPV 207

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BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
Match: nhlrc3 (NHL repeat containing 3 [Source:Xenbase;Acc:XB-GENE-988782])

HSP 1 Score: 140.969 bits (354), Expect = 1.506e-37
Identity = 65/136 (47.79%), Postives = 96/136 (70.59%), Query Frame = 2

Query: 1082 KLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKAS 1489
            +L  +++++W ES E L+N++ GLA F  +L+SEYSEENI+FW+ACE +K +  P+K+  +AQKI +DF++ +A +EVN+DS TR+ T  +I  P  + FD AQ RI  LME DSY+RFL+S+ Y  L+     AS
Sbjct:   89 RLRQDEVKKWAESLENLINNECGLAAFRAFLQSEYSEENIDFWLACENYKKVKTPEKLLEKAQKIYEDFISVEATREVNLDSATREETSNNIIQPTHSTFDEAQHRIFILMEKDSYRRFLKSKFYLDLVLSSSGAS 224

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BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
Match: sppl2b (signal peptide peptidase like 2B [Source:Xenbase;Acc:XB-GENE-958186])

HSP 1 Score: 131.724 bits (330), Expect = 2.375e-33
Identity = 59/126 (46.83%), Postives = 88/126 (69.84%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            + +  W +S E LL+  YG ALF  +L+SE+S+EN++FW+ACEE+K       + SRA+KI + ++  Q+PKEVN+D+ TR++T  ++  P    FD AQ+RI  LME DSY RFLRS++YQ+L+ 
Sbjct:  199 DDVTSWGKSLENLLSHTYGRALFRVFLQSEFSDENLDFWLACEEYKDTHPNFILHSRARKIYQLYIALQSPKEVNLDASTREMTEHNLLIPTRTTFDEAQRRIYGLMERDSYPRFLRSDLYQSLLH 324

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BLAST of Regulator of G-protein signaling vs. Ensembl Mouse
Match: Rgs8 (regulator of G-protein signaling 8 [Source:MGI Symbol;Acc:MGI:108408])

HSP 1 Score: 150.599 bits (379), Expect = 5.753e-42
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW ESF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   40 LKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 170

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Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW ESF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   40 LKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 170

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BLAST of Regulator of G-protein signaling vs. Ensembl Mouse
Match: Rgs8 (regulator of G-protein signaling 8 [Source:MGI Symbol;Acc:MGI:108408])

HSP 1 Score: 150.599 bits (379), Expect = 7.187e-42
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW ESF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

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BLAST of Regulator of G-protein signaling vs. Ensembl Mouse
Match: Rgs8 (regulator of G-protein signaling 8 [Source:MGI Symbol;Acc:MGI:108408])

HSP 1 Score: 150.599 bits (379), Expect = 7.187e-42
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW ESF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Mouse
Match: Rgs8 (regulator of G-protein signaling 8 [Source:MGI Symbol;Acc:MGI:108408])

HSP 1 Score: 150.599 bits (379), Expect = 7.187e-42
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW ESF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

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BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
Match: sp|O15539|RGS5_HUMAN (Regulator of G-protein signaling 5 OS=Homo sapiens OX=9606 GN=RGS5 PE=1 SV=1)

HSP 1 Score: 151.754 bits (382), Expect = 1.749e-41
Identity = 70/128 (54.69%), Postives = 100/128 (78.12%), Query Frame = 2

Query: 1088 LNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            L+E +Q W +S ++LL + YGLA F  +LKSE+SEEN+EFWIACE++K I +P KMA +A++I ++F+ T+APKEVNID  T+ IT++++  P+ + FDMAQKRI +LME DS  RF+RSE YQ L++
Sbjct:   55 LDEALQ-WRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK 181

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BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
Match: sp|P57771|RGS8_HUMAN (Regulator of G-protein signaling 8 OS=Homo sapiens OX=9606 GN=RGS8 PE=1 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 4.362e-41
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW +SF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ S+A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

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BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
Match: sp|Q8BXT1|RGS8_MOUSE (Regulator of G-protein signaling 8 OS=Mus musculus OX=10090 GN=Rgs8 PE=1 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 5.027e-41
Identity = 67/131 (51.15%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW ESF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

[Close]

BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
Match: sp|P49804|RGS8_RAT (Regulator of G-protein signaling 8 OS=Rattus norvegicus OX=10116 GN=Rgs8 PE=1 SV=2)

HSP 1 Score: 149.058 bits (375), Expect = 1.442e-40
Identity = 66/131 (50.38%), Postives = 96/131 (73.28%), Query Frame = 2

Query: 1076 MGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            + +L  E+  RW +SF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ ++A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   42 LKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 172

[Close]

BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
Match: sp|Q95K68|RGS8_MACFA (Regulator of G-protein signaling 8 OS=Macaca fascicularis OX=9541 GN=RGS8 PE=2 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 1.915e-40
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query: 1082 KLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            +L  E+  RW +SF+ LL+ KYG+A F  +LK+E+SEEN+EFW+ACEEFK   +  K+ S+A +I ++FV  QAP+EVNID +TR+ T +++Q P+   FD AQ ++ SLME DSY RFLRS+MY  L+
Sbjct:   60 RLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLL 188

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BLAST of Regulator of G-protein signaling vs. TrEMBL
Match: A0A1I8H9V0 (RGS domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 189.119 bits (479), Expect = 1.081e-52
Identity = 94/171 (54.97%), Postives = 123/171 (71.93%), Query Frame = 2

Query:  968 EKFNFL--RKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQD 1474
            EK NFL  + PG+ + P  +   +  S      EK VR  K   EQ+QRW  SF+ LLNDKYGLALF  +LK+EYS+ENIEFW+ACEE++ +T PKK A +AQKI  +FV  QAP+EVN+DS TR  T+ ++  P+ ++F+ AQKRIQ+LME DSYQRFLRSE+YQA ++D
Sbjct:    2 EKLNFLSRKSPGENS-PTSTKGRAGDSSAASASEKSVRAVKPNYEQVQRWGNSFDSLLNDKYGLALFRAFLKTEYSDENIEFWVACEEYRGLTGPKKQALKAQKIYNEFVAFQAPREVNLDSTTRLATINAMGSPDRHLFEQAQKRIQALMEKDSYQRFLRSEVYQAHLRD 171

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BLAST of Regulator of G-protein signaling vs. TrEMBL
Match: A0A267EQ09 (RGS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010798g1 PE=4 SV=1)

HSP 1 Score: 195.667 bits (496), Expect = 2.938e-52
Identity = 94/174 (54.02%), Postives = 124/174 (71.26%), Query Frame = 2

Query:  962 MKEKFNFL--RKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            + EK NFL  + PG+ + P  +   +  S      EK VR  K   EQ+QRW  SF+ LLNDKYGLALF  +LK+EYS+ENIEFW+ACEE++ +T PKK A +AQKI  +FV  QAP+EVN+DS TR  T+ ++  P+ ++F+ AQKRIQ+LME DSYQRFLRSE+YQA ++D 
Sbjct:  229 IGEKLNFLSRKSPGENS-PTSTKGRAGDSSAASASEKSVRAVKPNYEQVQRWGNSFDSLLNDKYGLALFRAFLKTEYSDENIEFWVACEEYRGLTGPKKQALKAQKIYNEFVAFQAPREVNLDSTTRLATINAMGSPDRHLFEQAQKRIQALMEKDSYQRFLRSEVYQAHLRDT 401

[Close]

BLAST of Regulator of G-protein signaling vs. TrEMBL
Match: A0A1I8JC59 (RGS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010798g2 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 6.745e-52
Identity = 93/174 (53.45%), Postives = 124/174 (71.26%), Query Frame = 2

Query:  962 MKEKFNFL--RKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            + EK NFL  + PG+ + P  +   +  S      EK VR  K   EQ+QRW  SF+ LLNDKYGLALF  +LK+EYS+ENIEFW+ACEE++ +T PK+ A +AQKI  +FV  QAP+EVN+DS TR  T+ ++  P+ ++F+ AQKRIQ+LME DSYQRFLRSE+YQA ++D 
Sbjct:  229 IGEKLNFLSRKSPGENS-PTSTKGRAGDSSAASASEKSVRAVKPNYEQVQRWGNSFDSLLNDKYGLALFRAFLKTEYSDENIEFWVACEEYRGLTGPKRQALKAQKIYNEFVAFQAPREVNLDSTTRLATINAMGSPDRHLFEQAQKRIQALMEKDSYQRFLRSEVYQAHLRDT 401

[Close]

BLAST of Regulator of G-protein signaling vs. TrEMBL
Match: A0A5J4NZD3 (Regulator of G-protein signaling OS=Paragonimus westermani OX=34504 GN=DEA37_0008906 PE=4 SV=1)

HSP 1 Score: 188.348 bits (477), Expect = 6.522e-51
Identity = 89/168 (52.98%), Postives = 121/168 (72.02%), Query Frame = 2

Query:  980 FLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKK 1483
            F +KP  P+V         KS+++KE+++++R GK   EQI  W  SFE LLND++GLALF D+L +E+S+ENIEFWIAC+E+K ITNPKK+A RAQKI ++F+  QA +EVN+DSKTR  T   + +P  +  D AQKRIQ+LME DSY+RFLRSE Y  L  + ++
Sbjct:   19 FRQKPNHPSV-------QVKSVQMKELKRMIRAGKPSFEQIHNWRHSFETLLNDRFGLALFKDFLSTEFSDENIEFWIACQEYKQITNPKKLAMRAQKIFEEFIAVQANREVNLDSKTRLQTEADLVNPTIHTLDNAQKRIQALMEKDSYRRFLRSEFYLTLYAEARE 179

[Close]

BLAST of Regulator of G-protein signaling vs. TrEMBL
Match: A0A504YEJ4 (Regulator of G protein signaling 3 OS=Fasciola gigantica OX=46835 GN=FGIG_00698 PE=4 SV=1)

HSP 1 Score: 192.586 bits (488), Expect = 9.421e-51
Identity = 105/254 (41.34%), Postives = 151/254 (59.45%), Query Frame = 2

Query:  803 LKTEPSTVPSLVHPSLTARSQRR----SKPDTKIITEISPEKKGAGKYKIIN-------IGIDEMKEKFNFLRKPGDPAVP----------------PLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKK 1483
            LK + S+ P++  PS T   Q+R    S P T    +++  +    K  ++N        G D    +   +R  G  + P                P S N S KS+++KE+++++R GK   EQI  W  SFE LLND++GLALF D+L +E+S+ENI FWIAC+E+K ITNPKK+A+RAQ+I  +F+  QA +EVN+DSKTR  T   + +PN    D AQKRIQ+LME DSY+RF+RSE+Y  L  + ++
Sbjct:   71 LKIDTSSSPTVTTPSGTGNQQKRESSQSGPSTVGYNQLATAED---KIDVVNHSAHCVQTGTDFFGSEQGGIRFYGSTSGPSSTKRTKIGIPFFRPKPSSPNQS-KSVQMKELKRMIRAGKPSYEQIHSWGHSFEALLNDRFGLALFKDFLSTEFSDENIAFWIACQEYKQITNPKKLAARAQRIYAEFIAVQANREVNLDSKTRLQTEAGLANPNIQTLDNAQKRIQALMEKDSYRRFIRSEVYLTLYTEARE 320

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BLAST of Regulator of G-protein signaling vs. Ensembl Cavefish
Match: rgs5a (regulator of G-protein signaling 5-like [Source:NCBI gene;Acc:103040381])

HSP 1 Score: 147.132 bits (370), Expect = 1.643e-40
Identity = 66/126 (52.38%), Postives = 93/126 (73.81%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            E+  +W ES +++LN+ YGLA F  +L+SE+SEENIEFW ACE++K   +P KMA++A+KI +DF+ T  PKEVNID  T+ +TL ++   +   FD+AQ RI +LME DS+ RFLRSE YQ L++
Sbjct:   69 EEASQWRESLDRVLNNSYGLATFRGFLRSEFSEENIEFWAACEDYKKTKSPLKMATKAKKIYEDFIQTGGPKEVNIDHFTKDVTLRNLVDLSPTTFDLAQSRIYTLMEKDSFGRFLRSEQYQELIK 194

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Cavefish
Match: rgs5a (regulator of G-protein signaling 5-like [Source:NCBI gene;Acc:103040381])

HSP 1 Score: 145.976 bits (367), Expect = 2.360e-40
Identity = 66/126 (52.38%), Postives = 93/126 (73.81%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            E+  +W ES +++LN+ YGLA F  +L+SE+SEENIEFW ACE++K   +P KMA++A+KI +DF+ T  PKEVNID  T+ +TL ++   +   FD+AQ RI +LME DS+ RFLRSE YQ L++
Sbjct:   57 EEASQWRESLDRVLNNSYGLATFRGFLRSEFSEENIEFWAACEDYKKTKSPLKMATKAKKIYEDFIQTGGPKEVNIDHFTKDVTLRNLVDLSPTTFDLAQSRIYTLMEKDSFGRFLRSEQYQELIK 182

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Cavefish
Match: rgs3a (regulator of G protein signaling 3a [Source:ZFIN;Acc:ZDB-GENE-040801-150])

HSP 1 Score: 144.821 bits (364), Expect = 6.964e-40
Identity = 78/178 (43.82%), Postives = 111/178 (62.36%), Query Frame = 2

Query:  959 EMKEKFNFLRK----PGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIK 1480
            +MK +  FLR+    PG      L D T   S+            K   E+  +W ES ++LL  KYGLA F  +L++E+SEEN+EFW+ACE++K I +  KMAS+A+KI  +++  Q+ KEVN+DS TR+ T E++Q+   + FD+AQ+RI  LME DSY RFLRSE+Y  L+   K
Sbjct:    4 DMKNRLAFLRRRNESPGSTPAGKL-DKTMKSSV------------KPTPEEALKWGESLDKLLVHKYGLAAFRAFLRTEFSEENLEFWLACEDYKKIKSQSKMASKAKKIFAEYIAIQSCKEVNLDSYTREHTKENLQNITRSCFDLAQRRIYGLMEKDSYPRFLRSELYMDLVNQKK 168

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BLAST of Regulator of G-protein signaling vs. Ensembl Cavefish
Match: rgs8 (regulator of G-protein signaling 8 [Source:NCBI gene;Acc:103027818])

HSP 1 Score: 144.436 bits (363), Expect = 8.976e-40
Identity = 65/136 (47.79%), Postives = 99/136 (72.79%), Query Frame = 2

Query: 1061 EKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E+  R  KL  +++ +W +SF+ LL++KYGLA+F  +LK+E+S+ENIEFW+ACE++K I +P K+ S+A KI  +F+  +AP+EVNID +TRQ T + +  P ++  +  Q ++ SLME DSY RFLRS+ YQ L+
Sbjct:   27 ERSARYLKLSPDEVTKWADSFDVLLSNKYGLAVFRAFLKTEFSDENIEFWLACEDYKKIKSPAKLVSKANKIYNEFIDVKAPREVNIDFRTRQDTKQKLLEPTSSSLNEIQAKVYSLMEKDSYPRFLRSKCYQDLL 162

[Close]

Query: 1061 EKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E+  R  KL  +++ +W +SF+ LL++KYGLA+F  +LK+E+S+ENIEFW+ACE++K I +P K+ S+A KI  +F+  +AP+EVNID +TRQ T + +  P ++  +  Q ++ SLME DSY RFLRS+ YQ L+
Sbjct:   27 ERSARYLKLSPDEVTKWADSFDVLLSNKYGLAVFRAFLKTEFSDENIEFWLACEDYKKIKSPAKLVSKANKIYNEFIDVKAPREVNIDFRTRQDTKQKLLEPTSSSLNEIQAKVYSLMEKDSYPRFLRSKCYQDLL 162

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BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008960.1 (pep scaffold:Pmarinus_7.0:GL487232:48:5367:1 gene:ENSPMAG00000008102.1 transcript:ENSPMAT00000008960.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 153.68 bits (387), Expect = 1.029e-43
Identity = 75/169 (44.38%), Postives = 111/169 (65.68%), Query Frame = 2

Query:  962 MKEKFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFK-TITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQAL 1465
            MK +  FLR+  DP+  P + + +           L +  +   E   +W+ESFE+LL  KYGLA F  +LK+E+SEENI+FW+ACE+FK +  +  K+ S+++KI ++F+  Q+PKEVN+DS TR++T+ ++Q P     D+AQKRI  LME DSY RFLRS++Y  L
Sbjct:   19 MKSRLGFLRRKPDPSDIPAASSPA-----------LGKHSRPSCEDAMKWSESFEKLLAHKYGLAAFRAFLKTEFSEENIDFWLACEDFKRSARSTSKLVSKSKKISEEFIAIQSPKEVNLDSSTREVTMANLQKPTVTSLDLAQKRIYGLMERDSYPRFLRSDLYHDL 176

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BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006812.1 (pep scaffold:Pmarinus_7.0:GL476397:246833:248901:1 gene:ENSPMAG00000006145.1 transcript:ENSPMAT00000006812.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 139.813 bits (351), Expect = 4.676e-39
Identity = 60/121 (49.59%), Postives = 88/121 (72.73%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMY 1456
            ++   W ES ++LL  KYGLA F  +L++E+SEENI FW+ACE++K   +  K+ S+A+KI  +++  Q+P EVN+DS TR++T  ++  P A+ FD+AQKRI  LME DSY RFLRS++Y
Sbjct:   30 DEAHAWAESLDKLLVHKYGLAAFQAFLRTEFSEENINFWLACEDYKKTKSAAKLTSKARKIFSEYIAIQSPNEVNLDSCTRELTAANLAKPTADAFDVAQKRIFGLMEKDSYPRFLRSQLY 150

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BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005413.1 (pep scaffold:Pmarinus_7.0:GL501287:7893:12072:-1 gene:ENSPMAG00000004924.1 transcript:ENSPMAT00000005413.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.775 bits (286), Expect = 2.804e-30
Identity = 57/124 (45.97%), Postives = 79/124 (63.71%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQAL 1465
            ++ + W+ES ++LL+ KYG   F  +L++E+SEEN+EFW+ACEEFK +    K  ++A+KI   F+   APKEVN+D  TR  T   +       F+ AQKRI  LME DSY RFL S +Y  L
Sbjct:    8 KEARAWSESLDRLLSHKYGRVAFLAFLRTEFSEENLEFWLACEEFKRMKAESKRLAQARKIYSQFIANHAPKEVNLDCLTRDATEAGLPGAAPGAFEPAQKRIYGLMERDSYPRFLLSPLYARL 131

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BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003940.1 (pep scaffold:Pmarinus_7.0:GL476449:561747:569035:-1 gene:ENSPMAG00000003600.1 transcript:ENSPMAT00000003940.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 117.087 bits (292), Expect = 3.539e-30
Identity = 55/146 (37.67%), Postives = 94/146 (64.38%), Query Frame = 2

Query: 1019 SDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMY 1456
            S   S+   +L+ I+     GKL  E++  W+  FE+L++   G A+F ++L++E+SEEN+ FW+ACE+ K   N   +  +A+ I +D+++  +PKEV++DS+ R++   ++  P+A+ FD AQ +I +LM  DSY RFL S +Y
Sbjct:   57 SRRRSSHESKLESIQSPEESGKLSLEEVTSWSHCFERLMHSAAGRAVFREFLRTEFSEENLLFWLACEDLKKEENKNIVEEKARTIYEDYISILSPKEVSLDSRVREVINRNMVEPSAHTFDDAQLQIYTLMHRDSYPRFLGSSVY 202

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BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008468.1 (pep scaffold:Pmarinus_7.0:GL476656:335513:340095:-1 gene:ENSPMAG00000007670.1 transcript:ENSPMAT00000008468.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.775 bits (286), Expect = 1.552e-29
Identity = 52/153 (33.99%), Postives = 100/153 (65.36%), Query Frame = 2

Query: 1031 SAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKAS 1489
            +++  R++ ++     GK   E++Q W +SF++L+    G   F ++L++E+SEEN+ FW+ACE+ K   N + +  +A+ I +D+++  +PKEV++DS+ R++   ++  P ++ FD AQ +I +LM  DSY RFL S++Y++L   + ++S
Sbjct:   51 ASRETRIEMVQNKDSSGKPSMEEVQVWGQSFDKLIRSTGGRNTFREFLRTEFSEENMLFWLACEDLKREANKRAVEEKARVIYEDYISILSPKEVSLDSRVREVINRNMLEPTSHTFDDAQLQIYTLMHRDSYPRFLNSQIYKSLQDSLAESS 203

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BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
Match: EDO37370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFZ6])

HSP 1 Score: 121.709 bits (304), Expect = 2.358e-32
Identity = 58/129 (44.96%), Postives = 83/129 (64.34%), Query Frame = 2

Query: 1091 NEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            +E+I  W  SFE+LL+ K G+ +FH++LKSEYSEEN+ FW+A E  K  T P  + + AQ I  D+V+T++PKEV+ID KTRQ+  + I  P    F  AQ+ +  +M  D Y RFL S  ++ L Q+ 
Sbjct:   27 SEEINEWGRSFERLLSSKNGIRVFHEFLKSEYSEENLLFWLAVERLKKETEPASVKNLAQTIYNDYVSTESPKEVSIDHKTRQVIDDEISQPTKETFSKAQQHVYYVMYQDCYPRFLSSSTFKTLQQEC 155

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
Match: EDO43126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZM8])

HSP 1 Score: 125.946 bits (315), Expect = 5.190e-30
Identity = 55/134 (41.04%), Postives = 92/134 (68.66%), Query Frame = 2

Query: 1097 QIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMY-QALMQDIKKASIP 1495
            ++ RW   F++L++D+ GL  F ++LK E+SEENI FWIACEEF++I++PKK+ S A  I +  ++  A   VNIDS   ++  E + +P  +M+ + Q+++ +LM+ DSY RFL+S++Y Q LM + +  ++P
Sbjct:  650 RVSRWALGFDKLMDDQAGLHCFEEFLKKEFSEENIVFWIACEEFRSISDPKKLKSAASTIFETHLSPNALMPVNIDSSAVKVAEEHLLNPTNHMYRVPQQQVYTLMKFDSYPRFLKSDLYRQCLMCEAEGVALP 783

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
Match: EDO32804 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SU35])

HSP 1 Score: 101.679 bits (252), Expect = 3.759e-25
Identity = 44/126 (34.92%), Postives = 82/126 (65.08%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            ++++ W   F  LL+ KYG+  F ++L+S+Y EEN+ FW+A E+++ + + +     A+ I +D+V+T +P E+++D+K R    +S+  P+ N FD AQ  I +LM  D + RF++S+ Y+ L++
Sbjct:   37 DEMKNWKHDFHALLSSKYGVNQFQEFLRSQYGEENLCFWLAVEDYRRLEDRESRRDMARMIYEDYVSTLSPTEISLDAKIRATVDKSMSDPDQNTFDPAQDHIYTLMYHDCFPRFIKSKHYKNLIK 162

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
Match: EDO34351 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPN2])

HSP 1 Score: 98.2117 bits (243), Expect = 5.648e-22
Identity = 48/125 (38.40%), Postives = 77/125 (61.60%), Query Frame = 2

Query: 1097 QIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
            +++RW  S  +LL D  G   F  +L+ E+S EN+ FW+ACE  K  T  K++  +AQ+I  ++++  +   +N+D KT +    +++ P   MFD AQ  I  LM+ DSY RFLRSE+Y+ L++
Sbjct:  269 RVKRWAFSLSELLKDPLGRKYFTRFLEKEFSAENLAFWLACERLKA-TPIKQVPEKAQEIYTEYLSEHSTSPINVDCKTHEEVEMNLEKPGRYMFDAAQDHIFQLMKSDSYSRFLRSELYKELLK 392

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
Match: EDO44861 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUI9])

HSP 1 Score: 53.5286 bits (127), Expect = 2.357e-7
Identity = 37/128 (28.91%), Postives = 61/128 (47.66%), Query Frame = 2

Query: 1100 IQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEF-KTITNPKKMASRAQKIIKDFVT-TQAPKEVNIDSKTR-QITLESIQHP-NANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQ 1471
             +RW  SF  LLND  G  LF+ YL+ E +   ++F   CE + + +    +M + A+ + + FV   Q  + + +   TR QI       P +  +FD A   + S M+   Y  F+ S +Y+   Q
Sbjct:   87 CERWANSFTDLLNDSDGSNLFYKYLRREGASILLDFSRECEAYRRMVPTSTQMRTTAKTLFQKFVYPRQFCELLGVKDTTRTQIAHHVNDQPADPALFDGAYAEVVSYMKKCHYVGFVNSNLYKDFTQ 214

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Medaka
Match: rgs8 (regulator of G-protein signaling 8 [Source:NCBI gene;Acc:101157608])

HSP 1 Score: 149.828 bits (377), Expect = 9.139e-42
Identity = 70/136 (51.47%), Postives = 97/136 (71.32%), Query Frame = 2

Query: 1061 EKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E   R  KL  +++ RW++SFE LL+ KYGLA F  +LKSE+S+ENIEFW+ACEE+K I +  K+ S+A KI K+F+  Q+P+EVNID +TR+ T +S+  P     +  Q +I SLME DSY RFLRS+MYQ ++
Sbjct:   27 ETTARCLKLSTDEVVRWSDSFEHLLSHKYGLAAFRTFLKSEFSDENIEFWMACEEYKKIKSSTKLLSKANKIFKEFIEVQSPREVNIDYRTREKTKQSLADPTPTSLNEVQGKIYSLMEKDSYPRFLRSKMYQDMI 162

[Close]

Query: 1061 EKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            E   R  KL  +++ RW++SFE LL+ KYGLA F  +LKSE+S+ENIEFW+ACEE+K I +  K+ S+A KI K+F+  Q+P+EVNID +TR+ T +S+  P     +  Q +I SLME DSY RFLRS+MYQ ++
Sbjct:   27 ETTARCLKLSTDEVVRWSDSFEHLLSHKYGLAAFRTFLKSEFSDENIEFWMACEEYKKIKSSTKLLSKANKIFKEFIEVQSPREVNIDYRTREKTKQSLADPTPTSLNEVQGKIYSLMEKDSYPRFLRSKMYQDMI 162

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Medaka
Match: rgs5a (regulator of G-protein signaling 5 [Source:NCBI gene;Acc:101158097])

HSP 1 Score: 146.362 bits (368), Expect = 2.321e-40
Identity = 65/132 (49.24%), Postives = 99/132 (75.00%), Query Frame = 2

Query: 1073 RMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALM 1468
            ++ K  +E+  +W ES +++LN+ YGL  F  +L+SE+S+ENIEFW+ACE+FK   NP KMA++A+KI +DF+ ++ P+EVNID  T+ +TL ++   + + F++AQKRI +LME DS+ RFLRSE YQ L+
Sbjct:   50 KLQKPTHEEAAQWRESLDRVLNNNYGLTAFRSFLQSEFSDENIEFWMACEDFKKTKNPVKMAAKAKKIYEDFIQSEGPREVNIDHFTKDVTLRNLVDLSPSTFELAQKRIFALMEKDSFARFLRSEQYQELL 181

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Medaka
Match: rgs3a (regulator of G protein signaling 3a [Source:ZFIN;Acc:ZDB-GENE-040801-150])

HSP 1 Score: 151.369 bits (381), Expect = 5.242e-39
Identity = 82/207 (39.61%), Postives = 125/207 (60.39%), Query Frame = 2

Query:  860 SQRRSKPDTKIITEISPEKKGAGKYKIINIGIDEMKEKFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIK 1480
            S R+    +    E+ P++    K K  N+  D MK +  FLR+           N S  S    +++K ++  K   E+  +W +S ++LL  KYGLA F  +L++E+SEEN+EFW+ACEE+K I +  KMAS+A+KI  +++  Q+ KEVN+DS TR  T +++Q+   + F++AQ+RI  LME DSY RFLRSE+Y  L+   K
Sbjct:  321 SGRKLSAGSPCSCEVGPDRT---KKKSKNLAKD-MKNRLAFLRR----------RNESPGSTPANKLDKSMKSVKPTPEEALKWGDSLDKLLAHKYGLAAFRAFLRTEFSEENLEFWLACEEYKKIKSQSKMASKAKKIFAEYIAIQSCKEVNLDSYTRDHTKDNLQNVTRSCFELAQRRIYGLMEKDSYPRFLRSELYSDLINQKK 513

[Close]

BLAST of Regulator of G-protein signaling vs. Ensembl Medaka
Match: rgs3a (regulator of G protein signaling 3a [Source:ZFIN;Acc:ZDB-GENE-040801-150])

HSP 1 Score: 151.369 bits (381), Expect = 5.296e-39
Identity = 82/207 (39.61%), Postives = 125/207 (60.39%), Query Frame = 2

Query:  860 SQRRSKPDTKIITEISPEKKGAGKYKIINIGIDEMKEKFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIK 1480
            S R+    +    E+ P++    K K  N+  D MK +  FLR+           N S  S    +++K ++  K   E+  +W +S ++LL  KYGLA F  +L++E+SEEN+EFW+ACEE+K I +  KMAS+A+KI  +++  Q+ KEVN+DS TR  T +++Q+   + F++AQ+RI  LME DSY RFLRSE+Y  L+   K
Sbjct:  326 SGRKLSAGSPCSCEVGPDRT---KKKSKNLAKD-MKNRLAFLRR----------RNESPGSTPANKLDKSMKSVKPTPEEALKWGDSLDKLLAHKYGLAAFRAFLRTEFSEENLEFWLACEEYKKIKSQSKMASKAKKIFAEYIAIQSCKEVNLDSYTRDHTKDNLQNVTRSCFELAQRRIYGLMEKDSYPRFLRSELYSDLINQKK 518

[Close]

BLAST of Regulator of G-protein signaling vs. Planmine SMEST
Match: SMESG000048981.1 (SMESG000048981.1)

HSP 1 Score: 936.791 bits (2420), Expect = 0.000e+0
Identity = 563/565 (99.65%), Postives = 565/565 (100.00%), Query Frame = 2

Query:   71 MDRMVSSSSMFQVNKSQLFIPNPGPLDAEGRVVSLPSLVIHEFKENRCKHESVKTSETIKKHSSWDDVNIDTSEDYPVSCMQVDXXXXXXXXXXXXXXXXXXXXXXXXLHLVRKLTSIYXXXXXXXXXXXXXXXXXXFDTSDITNTYQCNTQEGEISLRVPSISTGNSPLSDVSSTKENISGDKDEDENXXXXXXXXXXXHGKLGVPSKAAAILGAREIFTSPSHAAYRRLVDFTHRPTGDVPLLKTEPSTVPSLVHPSLTARSQRRSKPDTKIITEISPEKKGAGKYKIINIGIDEMKEKFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIPEPVPNSLPSMKPTSKIHSAQXXXXXXXXXXXXXXXXXXXXXXFRKNNKPEXXXXXXXXXXXXXXXXXXXXXXEANIPPSSSENCLKHSIR 1765
            MDRMVSSSSMFQVNKSQLFIPNPGPLDAEGRVVSLPSLVIHEFKENRCKHESVKTSETIKKHSSWDDVNIDTSEDYPVSCMQVDSSTSCIYIDSSVSSSSNSLSLSDTLHLVRKLTSIYDNQDSLSLLDNELLNASNFDTSDITNTYQCNTQEGEISLRVPSISTGNSPLSDVSSTKENISGDKDEDENSMSTSSSISPSHGKLGVPSKAAAILGAREIFTSPSHAAYRRLVDFTHRPTGDVPLLKTEPSTVPSLVHPSLTARSQRRSKPDTKI+TEISPEKKGAGKYKIINIGIDEMKEKFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIPEPVPNSLPSMKPTSKIHSAQSSVDVPDSDSLLSLRDIRSSCSFRKNNKPE+TTATSIIRISSVRSTRSDTVAEANIPPSSSENCLKHSIR
Sbjct:    1 MDRMVSSSSMFQVNKSQLFIPNPGPLDAEGRVVSLPSLVIHEFKENRCKHESVKTSETIKKHSSWDDVNIDTSEDYPVSCMQVDSSTSCIYIDSSVSSSSNSLSLSDTLHLVRKLTSIYDNQDSLSLLDNELLNASNFDTSDITNTYQCNTQEGEISLRVPSISTGNSPLSDVSSTKENISGDKDEDENSMSTSSSISPSHGKLGVPSKAAAILGAREIFTSPSHAAYRRLVDFTHRPTGDVPLLKTEPSTVPSLVHPSLTARSQRRSKPDTKIVTEISPEKKGAGKYKIINIGIDEMKEKFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASIPEPVPNSLPSMKPTSKIHSAQSSVDVPDSDSLLSLRDIRSSCSFRKNNKPETTTATSIIRISSVRSTRSDTVAEANIPPSSSENCLKHSIR 565

[Close]

BLAST of Regulator of G-protein signaling vs. Planmine SMEST
Match: SMESG000011723.1 (SMESG000011723.1)

HSP 1 Score: 202.986 bits (515), Expect = 1.351e-57
Identity = 126/288 (43.75%), Postives = 175/288 (60.76%), Query Frame = 2

Query:  686 VPSKAAAILGAREIFTSPSHAAYRRLVDFTHRPTGDVPLLKTEPSTVPSLVHPSLTARSQRRSKPDTKIITEISPEKKGAGKY----KIINIGIDEMKEKF-NFLRKPGDP---AVPPLSDNTSAKSI-----------RLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDIKKASI 1492
            +P+KAAAILGA +      +  ++ L D                S V   +         R+ KP   I+T  +       KY    + I IG  E+KEK  +F ++   P   A P +S N S+ ++           +LK++E+L+R+GK   EQI++W+ SFE LL+DKYGLALFH++L+SE+S+ENIEFWIACEE++TIT  KK+ SRA+KI  DFV  QA +EVN+DSKTRQ T   I++PN + FD AQKRIQ+LME DSYQRFLRSE+Y  L++  ++  I
Sbjct:  162 LPTKAAAILGADD------NLVFQSLHD------------SCPASKVQHALFLDQKLHENRQKKP---IVTPDTDPADAFSKYLKSKRKIGIG-SEVKEKIASFWKQSDQPLSSASPSVSTNYSSCTMPTHSSNIPGGFQLKDMERLLRVGKSSIEQIKKWSNSFECLLHDKYGLALFHEFLRSEFSDENIEFWIACEEYRTITTNKKLQSRAEKIYNDFVGVQAAREVNLDSKTRQQTEIDIRNPNPHTFDQAQKRIQALMEKDSYQRFLRSELYGKLVRACEEYQI 427

[Close]

BLAST of Regulator of G-protein signaling vs. Planmine SMEST
Match: SMESG000012254.1 (SMESG000012254.1)

HSP 1 Score: 159.458 bits (402), Expect = 5.571e-42
Identity = 81/187 (43.32%), Postives = 120/187 (64.17%), Query Frame = 2

Query:  947 IGIDEMKEKFNFLRKP-GDPAVPPLSDNTSAKS---------IRLKEIEKLVRMGKLLNEQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQDI 1477
            IG+D M+EK NF RK  G+ +  P S+ T+A           I L+ + K    G    EQ+  W++SFE +L D++G+ LF ++L+SE+S+EN+EFW  C+ +++I  PKK+  +A +I +D+V  Q+PKE+N+DS TR  T   I H     FD +QK+IQ+LME DSYQRFLRSE++  LM  +
Sbjct:  253 IGVD-MREKLNFFRKQQGENSSQPTSNTTAANRSSLVSPNFMINLENVWKATN-GCPSREQVLSWSQSFENILYDQHGITLFLEFLRSEFSDENLEFWSECQAYRSIKCPKKLQEKATQIFEDYVAEQSPKEINLDSVTRIQTATDIIHATKQTFDQSQKKIQALMEKDSYQRFLRSEIFHTLMSQL 437

[Close]

BLAST of Regulator of G-protein signaling vs. Planmine SMEST
Match: SMESG000027589.1 (SMESG000027589.1)

HSP 1 Score: 152.525 bits (384), Expect = 6.664e-41
Identity = 69/127 (54.33%), Postives = 96/127 (75.59%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQD 1474
            +QI+RW  S E LL D+YGLALF+ +LK+EYS+EN+EFW+ACE +K+++  KK+   AQKI    ++ QAP+EVN+DSKTR  T+ S+  P+   FD AQKRI +LME DSY RFLRS++YQ + ++
Sbjct:  204 DQIKRWEYSLEHLLADRYGLALFNAFLKTEYSDENLEFWMACESYKSLSGQKKLYKEAQKIYSQHLSVQAPREVNLDSKTRLQTISSLGTPSKMTFDSAQKRIFALMEKDSYPRFLRSDIYQIVYRE 330

[Close]

BLAST of Regulator of G-protein signaling vs. Planmine SMEST
Match: SMESG000053355.1 (SMESG000053355.1)

HSP 1 Score: 122.479 bits (306), Expect = 5.601e-32
Identity = 56/127 (44.09%), Postives = 83/127 (65.35%), Query Frame = 2

Query: 1094 EQIQRWNESFEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQKIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEIDSYQRFLRSEMYQALMQD 1474
            E I  W    E +LND YGL  F+++LKSEYS EN+ FW+ACE+FKTI + KK+   A  I ++++   +  EVN+D+K R+  +E +  PN  +F++AQ  I  LM  DSY RFL+S+ Y  +++D
Sbjct:   58 ENILSWKNGLEFILNDYYGLYYFNEFLKSEYSVENLNFWLACEKFKTIQSRKKLDEIANSIYQEYIAIGSENEVNLDAKLRRNIIEQMNSPNKKLFELAQSSIFILMAKDSYCRFLKSKCYLDMIKD 184

The following BLAST results are available for this feature:

BLAST of Regulator of G-protein signaling vs. Ensembl Human
BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
BLAST of Regulator of G-protein signaling vs. Ensembl Fly
BLAST of Regulator of G-protein signaling vs. Ensembl Zebrafish
BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
BLAST of Regulator of G-protein signaling vs. Ensembl Mouse
BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
BLAST of Regulator of G-protein signaling vs. TrEMBL
BLAST of Regulator of G-protein signaling vs. Ensembl Cavefish
BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
BLAST of Regulator of G-protein signaling vs. Ensembl Yeast
BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
BLAST of Regulator of G-protein signaling vs. Ensembl Medaka
BLAST of Regulator of G-protein signaling vs. Planmine SMEST

BLAST of Regulator of G-protein signaling vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RGS5	3.643e-42	54.69	regulator of G protein signaling 5 [Source:HGNC Sy...	[more]
RGS8	9.082e-42	51.15	regulator of G protein signaling 8 [Source:HGNC Sy...	[more]
RGS8	9.082e-42	51.15	regulator of G protein signaling 8 [Source:HGNC Sy...	[more]
RGS8	9.082e-42	51.15	regulator of G protein signaling 8 [Source:HGNC Sy...	[more]
RGS3	1.542e-41	44.13	regulator of G protein signaling 3 [Source:HGNC Sy...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rgs-2	2.483e-30	45.00	Regulator of G-protein signaling rgs-2 [Source:Un...	[more]
rgs-2	3.872e-30	44.00	Regulator of G-protein signaling rgs-2 [Source:Un...	[more]
rgs-2	5.800e-30	45.00	Regulator of G-protein signaling rgs-2 [Source:Un...	[more]
rgs-2	6.257e-30	45.00	Regulator of G-protein signaling rgs-2 [Source:Un...	[more]
rgs-1	2.564e-28	45.60	Regulator of G-protein signaling rgs-1 [Source:Un...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dhit	4.794e-28	39.68	gene:FBgn0028743 transcript:FBtr0340279	[more]
Dhit	5.322e-28	39.68	gene:FBgn0028743 transcript:FBtr0301142	[more]
loco	6.567e-24	37.04	gene:FBgn0020278 transcript:FBtr0084275	[more]
loco	7.148e-24	37.04	gene:FBgn0020278 transcript:FBtr0304669	[more]
loco	7.670e-24	37.04	gene:FBgn0020278 transcript:FBtr0084276	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RGS13	8.131e-43	53.03	si:ch211-117l17.5 [Source:ZFIN;Acc:ZDB-GENE-110914...	[more]
BX936311.1	8.320e-43	53.03	si:ch211-117l17.5 [Source:NCBI gene;Acc:792554]	[more]
RGS13	1.949e-42	53.03	si:ch211-117l17.5 [Source:ZFIN;Acc:ZDB-GENE-110914...	[more]
rgs8	6.133e-41	49.26	regulator of G protein signaling 8 [Source:NCBI ge...	[more]
rgs8	6.133e-41	49.26	regulator of G protein signaling 8 [Source:NCBI ge...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cipc	1.388e-39	45.26	CLOCK-interacting pacemaker [Source:Xenbase;Acc:XB...	[more]
cipc	1.618e-39	45.26	CLOCK-interacting pacemaker [Source:Xenbase;Acc:XB...	[more]
fancd2os	2.502e-38	48.44	FANCD2 opposite strand [Source:Xenbase;Acc:XB-GENE...	[more]
nhlrc3	1.506e-37	47.79	NHL repeat containing 3 [Source:Xenbase;Acc:XB-GEN...	[more]
sppl2b	2.375e-33	46.83	signal peptide peptidase like 2B [Source:Xenbase;A...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rgs8	5.753e-42	51.15	regulator of G-protein signaling 8 [Source:MGI Sym...	[more]
Rgs8	5.753e-42	51.15	regulator of G-protein signaling 8 [Source:MGI Sym...	[more]
Rgs8	7.187e-42	51.15	regulator of G-protein signaling 8 [Source:MGI Sym...	[more]
Rgs8	7.187e-42	51.15	regulator of G-protein signaling 8 [Source:MGI Sym...	[more]
Rgs8	7.187e-42	51.15	regulator of G-protein signaling 8 [Source:MGI Sym...	[more]

BLAST of Regulator of G-protein signaling vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O15539\|RGS5_HUMAN	1.749e-41	54.69	Regulator of G-protein signaling 5 OS=Homo sapiens...	[more]
sp\|P57771\|RGS8_HUMAN	4.362e-41	51.15	Regulator of G-protein signaling 8 OS=Homo sapiens...	[more]
sp\|Q8BXT1\|RGS8_MOUSE	5.027e-41	51.15	Regulator of G-protein signaling 8 OS=Mus musculus...	[more]
sp\|P49804\|RGS8_RAT	1.442e-40	50.38	Regulator of G-protein signaling 8 OS=Rattus norve...	[more]
sp\|Q95K68\|RGS8_MACFA	1.915e-40	51.94	Regulator of G-protein signaling 8 OS=Macaca fasci...	[more]

BLAST of Regulator of G-protein signaling vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8H9V0	1.081e-52	54.97	RGS domain-containing protein OS=Macrostomum ligna...	[more]
A0A267EQ09	2.938e-52	54.02	RGS domain-containing protein OS=Macrostomum ligna...	[more]
A0A1I8JC59	6.745e-52	53.45	RGS domain-containing protein OS=Macrostomum ligna...	[more]
A0A5J4NZD3	6.522e-51	52.98	Regulator of G-protein signaling OS=Paragonimus we...	[more]
A0A504YEJ4	9.421e-51	41.34	Regulator of G protein signaling 3 OS=Fasciola gig...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rgs5a	1.643e-40	52.38	regulator of G-protein signaling 5-like [Source:NC...	[more]
rgs5a	2.360e-40	52.38	regulator of G-protein signaling 5-like [Source:NC...	[more]
rgs3a	6.964e-40	43.82	regulator of G protein signaling 3a [Source:ZFIN;A...	[more]
rgs8	8.976e-40	47.79	regulator of G-protein signaling 8 [Source:NCBI ge...	[more]
rgs8	8.976e-40	47.79	regulator of G-protein signaling 8 [Source:NCBI ge...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000008960.1	1.029e-43	44.38	pep scaffold:Pmarinus_7.0:GL487232:48:5367:1 gene:...	[more]
ENSPMAT00000006812.1	4.676e-39	49.59	pep scaffold:Pmarinus_7.0:GL476397:246833:248901:1...	[more]
ENSPMAT00000005413.1	2.804e-30	45.97	pep scaffold:Pmarinus_7.0:GL501287:7893:12072:-1 g...	[more]
ENSPMAT00000003940.1	3.539e-30	37.67	pep scaffold:Pmarinus_7.0:GL476449:561747:569035:-...	[more]
ENSPMAT00000008468.1	1.552e-29	33.99	pep scaffold:Pmarinus_7.0:GL476656:335513:340095:-...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Regulator of G-protein signaling vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO37370	2.358e-32	44.96	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43126	5.190e-30	41.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32804	3.759e-25	34.92	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34351	5.648e-22	38.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44861	2.357e-7	28.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Regulator of G-protein signaling vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rgs8	9.139e-42	51.47	regulator of G-protein signaling 8 [Source:NCBI ge...	[more]
rgs8	9.139e-42	51.47	regulator of G-protein signaling 8 [Source:NCBI ge...	[more]
rgs5a	2.321e-40	49.24	regulator of G-protein signaling 5 [Source:NCBI ge...	[more]
rgs3a	5.242e-39	39.61	regulator of G protein signaling 3a [Source:ZFIN;A...	[more]
rgs3a	5.296e-39	39.61	regulator of G protein signaling 3a [Source:ZFIN;A...	[more]

BLAST of Regulator of G-protein signaling vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000048981.1	0.000e+0	99.65	SMESG000048981.1	[more]
SMESG000011723.1	1.351e-57	43.75	SMESG000011723.1	[more]
SMESG000012254.1	5.571e-42	43.32	SMESG000012254.1	[more]
SMESG000027589.1	6.664e-41	54.33	SMESG000027589.1	[more]
SMESG000053355.1	5.601e-32	44.09	SMESG000053355.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30002009 ID=SMED30002009|Name=Regulator of G-protein signaling|organism=Schmidtea mediterranea sexual|type=transcript|length=1868bp
ATGGGATTGGCTAGGAAACAAATTGAGTATCTCAATGAATGCTGCTTGAT
AATAACAATAACGTTTCACAATGGATCGAATGGTGTCAAGTTCTTCGATG
TTTCAAGTCAACAAGTCACAATTATTCATTCCAAATCCCGGCCCCCTCGA
TGCAGAAGGCAGAGTCGTTTCGTTGCCTTCACTTGTAATTCATGAATTTA
AAGAAAATCGATGCAAACATGAAAGCGTTAAAACGTCAGAGACAATTAAA
AAGCATAGCTCTTGGGATGATGTTAACATTGATACGTCGGAAGATTATCC
GGTTTCCTGTATGCAAGTAGATAGTAGTACTTCGTGTATTTATATCGATT
CATCCGTCTCATCCTCTTCGAACTCCTTATCTCTCTCAGACACTCTCCAT
CTTGTGAGAAAGTTGACAAGTATCTATGATAATCAGGATTCGTTGAGTTT
ATTAGATAATGAGTTGCTGAATGCATCAAATTTTGACACCAGTGATATTA
CAAACACTTATCAATGTAATACGCAAGAAGGAGAAATATCTCTTAGGGTG
CCCAGCATTTCTACTGGTAACTCTCCACTTTCTGATGTGTCCTCGACCAA
GGAAAATATCAGTGGAGATAAAGATGAAGATGAAAACTCTATGTCAACTT
CGTCGTCGATCTCTCCTTCACACGGAAAGCTTGGAGTGCCCTCTAAAGCT
GCCGCAATTCTAGGTGCGAGAGAAATATTCACTTCTCCTAGTCATGCTGC
TTATCGGCGATTAGTGGATTTTACTCACAGACCAACTGGTGATGTTCCTC
TACTGAAAACCGAACCGTCGACAGTTCCATCGTTAGTCCATCCAAGTTTG
ACTGCTCGAAGTCAACGTCGAAGCAAGCCCGATACGAAAATCATAACAGA
GATTTCTCCGGAGAAAAAAGGGGCCGGGAAATATAAAATCATTAACATCG
GAATTGATGAAATGAAAGAAAAATTCAACTTCCTCCGAAAGCCAGGTGAC
CCAGCAGTGCCACCCCTTTCGGATAATACTTCAGCAAAATCTATTCGACT
CAAAGAAATAGAAAAACTCGTCAGAATGGGTAAGTTACTGAATGAACAAA
TACAAAGATGGAACGAATCATTTGAGCAGCTATTGAATGATAAATATGGA
TTGGCCTTATTTCACGATTACCTCAAATCCGAATACAGTGAAGAAAATAT
AGAATTTTGGATTGCATGCGAAGAATTTAAAACGATCACAAATCCAAAGA
AAATGGCATCGAGAGCTCAAAAAATTATCAAAGACTTTGTGACTACGCAA
GCTCCTAAAGAAGTGAACATTGATTCAAAAACCCGACAAATAACGTTAGA
GAGCATCCAACACCCAAATGCAAACATGTTTGACATGGCCCAGAAAAGGA
TCCAATCACTAATGGAAATAGATTCCTATCAACGATTCTTACGTTCCGAA
ATGTACCAAGCTTTAATGCAAGATATAAAAAAAGCGAGTATTCCCGAACC
AGTTCCAAACTCATTACCTTCTATGAAACCGACTAGTAAGATACACTCTG
CTCAGAGCAGTGTAGACGTTCCAGATTCAGATAGCCTACTTTCCTTGAGG
GACATCCGTTCCTCATGTTCTTTTAGAAAGAATAACAAGCCTGAGTCAAC
AACAGCGACGTCAATTATCAGAATCAGCTCCGTCAGATCAACCAGATCAG
ATACAGTGGCTGAAGCAAACATTCCGCCGAGTTCATCCGAAAATTGTCTG
AAACATAGCATTAGATAATGACTAGTGGAAATATTATCCATATTATCAGT
TATTATGTACTCGAACTTTGAAAATTTGTTTTCGTTCGAAATCGGTATTG
AATTAAAAGTTAAGTTCG

protein sequence of SMED30002009-orf-1

>SMED30002009-orf-1 ID=SMED30002009-orf-1|Name=SMED30002009-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=105bp
NLTFNSIPISNENKFSKFEYIITDNMDNISTSHYLMLCFRQFSDELGGMF
ASATVSDLVDLTELILIIDVAVVDSGLLFFLKEHEERMSLKESRLSESGT
STLL*

protein sequence of SMED30002009-orf-2

>SMED30002009-orf-2 ID=SMED30002009-orf-2|Name=SMED30002009-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=566bp
MDRMVSSSSMFQVNKSQLFIPNPGPLDAEGRVVSLPSLVIHEFKENRCKH
ESVKTSETIKKHSSWDDVNIDTSEDYPVSCMQVDSSTSCIYIDSSVSSSS
NSLSLSDTLHLVRKLTSIYDNQDSLSLLDNELLNASNFDTSDITNTYQCN
TQEGEISLRVPSISTGNSPLSDVSSTKENISGDKDEDENSMSTSSSISPS
HGKLGVPSKAAAILGAREIFTSPSHAAYRRLVDFTHRPTGDVPLLKTEPS
TVPSLVHPSLTARSQRRSKPDTKIITEISPEKKGAGKYKIINIGIDEMKE
KFNFLRKPGDPAVPPLSDNTSAKSIRLKEIEKLVRMGKLLNEQIQRWNES
FEQLLNDKYGLALFHDYLKSEYSEENIEFWIACEEFKTITNPKKMASRAQ
KIIKDFVTTQAPKEVNIDSKTRQITLESIQHPNANMFDMAQKRIQSLMEI
DSYQRFLRSEMYQALMQDIKKASIPEPVPNSLPSMKPTSKIHSAQSSVDV
PDSDSLLSLRDIRSSCSFRKNNKPESTTATSIIRISSVRSTRSDTVAEAN
IPPSSSENCLKHSIR*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0009968	negative regulation of signal transduction
GO:0043547	positive regulation of GTPase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000074	oocyte
PLANA:0000099	neuron
PLANA:0000231	vitelline gland
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR036305	RGS_sf
IPR016137	RGS
IPR024066	RGS_subdom1/3

Vocabulary: **molecular function**
Term	Definition
GO:0005096	GTPase activator activity

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR016137	RGS domain	PRINTS	PR01301	RGSPROTEIN	coord: 369..387 score: 63.27 coord: 347..368 score: 41.4 coord: 398..421 score: 42.39 coord: 440..459 score: 58.48
IPR016137	RGS domain	SMART	SM00315	RGS_3	coord: 350..466 e-value: 2.0E-48 score: 176.9
IPR016137	RGS domain	PFAM	PF00615	RGS	coord: 350..465 e-value: 2.4E-34 score: 118.1
IPR016137	RGS domain	PROSITE	PS50132	RGS	coord: 350..466 score: 36.049
IPR024066	RGS, subdomain 1/3	GENE3D	G3DSA:1.10.196.10		coord: 341..376 e-value: 1.8E-12 score: 49.2
IPR024066	RGS, subdomain 1/3	GENE3D	G3DSA:1.10.196.10		coord: 447..473 e-value: 3.4E-6 score: 28.8
None	No IPR available	GENE3D	G3DSA:1.10.167.10		coord: 377..446 e-value: 3.5E-32 score: 112.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 158..177
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 543..565
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 158..203
None	No IPR available	PANTHER	PTHR10845	REGULATOR OF G PROTEIN SIGNALING	coord: 294..471
None	No IPR available	PANTHER	PTHR10845:SF242	NOVEL PROTEIN SIMILAR TO VERTEBRATE REGULATOR OF G-PROTEIN SIGNALLING FAMILY-RELATED	coord: 294..471
IPR036305	RGS domain superfamily	SUPERFAMILY	SSF48097	Regulator of G-protein signaling, RGS	coord: 343..468

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Regulator of G-protein signaling

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 16

Owlery

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