DNA topoisomerase 2

Overview
NameDNA topoisomerase 2
Smed IDSMED30001991
Length (bp)3743
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DNA topoisomerase 2 (SMED30001991) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA topoisomerase 2 (SMED30001991) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA topoisomerase 2 (SMED30001991) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA topoisomerase 2 (SMED30001991) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30001991

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30001991SMESG000064303.1 SmedASXL_017089SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30001991SMESG000064303.1 dd_Smed_v4_14064_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30001991SMESG000064303.1 dd_Smed_v4_14064_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30001991SMESG000064303.1 SMESG000064314.1 Contig19558newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30001991SMESG000064303.1 SMESG000064314.1 Contig19558uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2A (DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989])

HSP 1 Score: 1041.57 bits (2692), Expect = 0.000e+0
Identity = 528/1142 (46.23%), Postives = 758/1142 (66.37%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+S      +KQTW +NM +  E  ++   G D+T ITF+PDL++FKM +LD DI+AL  RRA+DIA + K+V ++ N  ++P+  F+ YV++Y         N  + IH  +N+  EV +T+S    F QISFVN I T  GG HV+   +++V  LV     ++K+  K    ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T  P  F S   LS+KF+   I CG++E I + +  K         S  K N I  I KLDDA  AG + S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+K  K+ Q + FYS   ++ W  +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F ++Q   RKEW+  +++ R+      + E+ ++ +  T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP  DD+ L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  +I+ N+R L++ + P+ M+P Y+NFKG+I E    +Y  +G+  ILNS T+E+ ELP+   TQ YKE ++  ML  ++    ++ DY + +TDT V+F++ +   KL   E R+ L ++  L + ++  +MVLFD    +K+Y T ++IL +FF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  +DSDP+K W++A +K     + +        E  D        F YLL+MP+   TK+K + L  L   K  E + L R+SP
Sbjct:   29 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVTKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSP 1163
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2B (DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990])

HSP 1 Score: 1026.93 bits (2654), Expect = 0.000e+0
Identity = 522/1140 (45.79%), Postives = 748/1140 (65.61%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    +  +E+ +VP L+KIFDEILVNA+DNK+RD  M+ IK++++ + N ISI N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNM + +E  I+   G D+T ITF+PDL++FKM+ LD DI+AL  RRA+D+A + + V + FN  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+F+N ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+KA K+ Q + FYS   +  W K   +   W+IKYYKGLGTST+ EAKEYF ++++HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   +PNY+  +I+ N+R +L+   P  M+P Y+NFKG+I E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  V  + AE+ K  NQ RFI  K  GK+ + N ++ +   +L Q  ++SDP+K W++A +K     E +   +D           DF Y+LNM + S TK+K+E L     +K  E   L R+SP
Sbjct:   50 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSP 1181
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2B (DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990])

HSP 1 Score: 1026.54 bits (2653), Expect = 0.000e+0
Identity = 522/1140 (45.79%), Postives = 748/1140 (65.61%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    +  +E+ +VP L+KIFDEILVNA+DNK+RD  M+ IK++++ + N ISI N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNM + +E  I+   G D+T ITF+PDL++FKM+ LD DI+AL  RRA+D+A + + V + FN  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+F+N ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+KA K+ Q + FYS   +  W K   +   W+IKYYKGLGTST+ EAKEYF ++++HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   +PNY+  +I+ N+R +L+   P  M+P Y+NFKG+I E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  V  + AE+ K  NQ RFI  K  GK+ + N ++ +   +L Q  ++SDP+K W++A +K     E +   +D           DF Y+LNM + S TK+K+E L     +K  E   L R+SP
Sbjct:   45 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSP 1176
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2B (DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990])

HSP 1 Score: 1012.68 bits (2617), Expect = 0.000e+0
Identity = 512/1114 (45.96%), Postives = 734/1114 (65.89%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFT 3423
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    +  +E+ +VP L+KIFDEILVNA+DNK+RD  M+ IK++++ + N ISI N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNM + +E  I+   G D+T ITF+PDL++FKM+ LD DI+AL  RRA+D+A + + V + FN  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+F+N ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+KA K+ Q + FYS   +  W K   +   W+IKYYKGLGTST+ EAKEYF ++++HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   +PNY+  +I+ N+R +L+   P  M+P Y+NFKG+I E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  V  + AE+ K  NQ RFI  K  GK+ + N ++ +   +L Q  ++SDP+K W++A +K     E +   +D           DF Y+LNM + S T
Sbjct:   45 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLT 1150
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2A (DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989])

HSP 1 Score: 154.836 bits (390), Expect = 6.944e-43
Identity = 72/132 (54.55%), Postives = 98/132 (74.24%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFT 561
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K T
Sbjct:   17 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 147
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: top-2 (DNA topoisomerase 2 top-2 [Source:UniProtKB/Swiss-Prot;Acc:Q23670])

HSP 1 Score: 1003.43 bits (2593), Expect = 0.000e+0
Identity = 504/1151 (43.79%), Postives = 757/1151 (65.77%), Query Frame = 1 
Query:  169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKS-QWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYD---NNDSQ---FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLN----LRNFNEHEANLLLKQNSFDSDPIKIWEQALK-KEHR-----IFDEDPVKKGIFEES--------------YDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRS 3498
            IE  YQKK+ +EHIL RPD+Y+GS+  + K+  W+++  ++K+ +++I YVP L+KI+DEILVNA+DNK+RD +M+ IKI +N+++NEIS+ N+G GIPV  H  E +Y+P LIFG LLTSSNY+D  +K TGGRNG+GAKLCN+FS  F++ETSS      +KQTW  NMT+  EP I K+   DFT ITF PDL +FKM  LD DI  L  RRA+D+A + K V+++ N  +IPI  F+ YV++Y    NN+ +     +  + +  +VA+ LS    F Q+SFVN I T  GG HV+   +++V   +   +  + + +  I+P QIKN +W+FVN ++ NP F+SQ+KE +T    +F S  +LS+KF       G+ + + S +  K+    +   S  K + +  I KL+DA  AGTK S +CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    +++  N +   ++  LG+ YKKKY T++  K+LRYGK+M+MADQD DGSHIKGL++NF HH WP L+Q +F E+FITPI+KA K  + + FYS   Y  W   T ++  ++IKYYKGLGTSTS EAKEYF ++ +HR  F Y+G++DD  + M F +++  +RK+W+ +W++++K   ++ + EE ++ K+   +++KDF+N+EL+++SN DN R+IP ++DG KP QRK+++ C KR   ++VKV QL+G+V+E++ YHH E+S+  T+++LAQDYVGSNNINLL+P+G FGTR+ GGKD+ASARYI T+LSP+ R +FPA DDN L+  Y++NQ IEP WY PIIP VL+NGA G+GTGW T IPNYNP ++++N++ L+  +P   + PWY+NF+G I + D  ++   G+  +L+  T+E+ ELPI   TQ YKE ++  ++ +S     ++ DY++ +TDT V+F++ L   KL   E   +L Q+  L + I+TT MVLFD    ++ Y++P  I  EF+ +R   Y +RK++ +  + A++K+  NQ RFI    K+N    L N  +     +L +  FD+DP+K W++  K KE R       DED +     EE                D+ YL+ M +   ++++   L    + K+ E  ++ +++
Sbjct:   63 IEDIYQKKSQLEHILLRPDTYIGSVEHTEKTPMWVYNMEESKLEQRDISYVPGLYKIYDEILVNAADNKQRDPKMNTIKITINKEKNEISVYNNGKGIPVTQHKVEKVYVPELIFGTLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTKFTLETSSRDYKSAFKQTWIKNMTRDEEPKIVKSTDEDFTKITFSPDLAKFKMKELDDDICHLMARRAYDVAGSSKGVAVFLNGKRIPIKGFEDYVQMYTSQFNNEGEPLKIAYEQVGDRWQVALALSEK-GFQQVSFVNSIATTKGGRHVDYVADQMVAKFIDSIKRKLTKTSMNIKPFQIKNHMWVFVNCLIENPTFDSQTKETMTLQQKQFGSTCVLSEKFSKAASSVGITDAVMSWVRFKQMDDLNKKCSKTKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPLRGKLLNVREGNMKQIADNAEVNAMIKILGLQYKKKYETEDDFKTLRYGKLMVMADQDQDGSHIKGLVINFIHHFWPSLIQRNFVEEFITPIVKATKGKEEVSFYSLPEYSEWRMNTDNWKSYKIKYYKGLGTSTSKEAKEYFLDMVRHRIRFKYNGADDDNAVDMAFSKKKIEERKDWLSKWMREKKDRKQQGLAEEYLYNKDTRFVTFKDFVNRELVLFSNLDNERSIPCLVDGFKPGQRKVLFACFKRADKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASARYIFTQLSPVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGIGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPSRFACYGEVAVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGCLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFI--LAKINNEIVLENKKKAAIVDVLIKMKFDADPVKKWKEEQKLKELRESGEIELDEDDLAAVAVEEDEAISSAAKAVETKLSDYDYLVGMALIKLSEEEKNKLIKESEEKMAEVRVIEKKT 1210
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: R05D3.12 (Putative DNA topoisomerase 2, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P34534])

HSP 1 Score: 798.89 bits (2062), Expect = 0.000e+0
Identity = 466/1163 (40.07%), Postives = 701/1163 (60.28%), Query Frame = 1 
Query:   76 LKYFNNISHSLSI-----RCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSIN-KSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEP-VIE--KAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNL-KNVSIYFNDTQIPITSFKQYVELYDNNDS-QFIHNTINNSLEVAVT---LSTSYSFTQ--ISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIID-CGLLERI-QSMMNM-KKDFPKSLRKVNNILDIVKLDDALHAG-TKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYK-KKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKR-NFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLND-KPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSK-------TLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHL--KLDLKEIRLNLDQLLN---LSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAK--KSENQLRFIKDA--GKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENL 3444
            LK+  + SH  ++     R   +N+P+T  S   E   K Y+KK+  EH+L RPD+Y+G +  +  +  W+ D    K+I KE+ Y P L KIFDEILVNA+DNK RD  M+ +++ ++R+   IS+ N+GSG+PV +H TE +Y+PTL+FGNL TSSNYDDS  K  GGRNG+GAKLCN+FSK F VET       R++Q W +NM +  E  V+E       D+T + F PDL RF++D L  D+I L  RR F++A+ L ++V +Y N  +  +  F+ YV++++++ S  F+H T    + VA        S+      +SFVN INT  GG HV+  ++K+V ++    ++ + +  K ++P  IKN+L IF+N ++ NP FESQ+KE LT+    F S      K      +  GL+E I + ++NM KK  P     V+++ DIVKL+DA  AG T  + +CTLILTEGDSAK+ A++GL+VLG++ +GVF L+GK LN  N+ + +   N++  +++  LG+ ++    +T+E   SLRYG+++I+ADQD DGSHIKGLI+NF H  WP L+  D F + F TP++KA K  +   F+S N Y+ W     +  KW+IKYYKGLGTSTS EA+EYF ++D H  +F Y+G+ DD  ++M F+R++S +RKEWI     +R      N D+       KT ISY++F++ +L+ +   D  R+IPS++DGLKPSQRKI++T L   +   ++KV+QL+G+V+   +YHH E+S+  T+I + Q + GS+N+ LL P+G FGTR  GG D ASARYI T L+P  R +FP ADD+ LQ   ++   +EP W  PI+P +LING  G+GTGW T I N NP  II+ +R  ++      ++ P+Y  F+G +      K+ ++GK +++  +       ++E+ ELPIGI T KYKE +    +V +  ++ ++ +R+T+  V F I L  K   + ++ +   LLN   L + + T N VLFD + E+K +    EI  EFF+ R  +YEKR    +QK   EAK    ENQL FI+    G + +R+   ++    L++  F  DP+    +  KK                   ++GYLL MPV   T D+++ L
Sbjct:   10 LKFCISTSHRTTVVLKNTRSFCNNIPST--SFASEAAAK-YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRE---SLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADVE-EGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWI-----RRSENEITNEDD------GKTEISYQEFVDGQLMQFGMVDLKRSIPSLIDGLKPSQRKILWTLLNNMDESTEIKVSQLAGAVAHRQSYHHGEESLVRTIIRMGQTFCGSSNLPLLQPIGQFGTRHEGGNDAASARYIFTALAPTTRLLFPQADDDLLQKNVEEGMVVEPTWLCPIVPLILINGTEGIGTGWSTKIANRNPIDIIDMIRRKIDSISTEYEIPPFYEEFRGKLEVVTPTKFISSGKIQLIRPERKNASTFSIEIVELPIGIWTSKYKEKLSK--IVETLPVL-EFSERHTEKRVHFRITLDRKKSSRFLQKSNSDLLNYFKLRTSL-TENRVLFDRNGELKEFGNISEIAAEFFEVRRDLYEKRLK--IQKEECEAKLIYVENQLNFIEMVTNGTIEIRSMGRNQLEEKLQEMGFRVDPMATIAKNSKK------------------ANYGYLLEMPVSRLTSDEMKRL 1130
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: cin-4 (DNA topoisomerase-like protein cin-4 [Source:UniProtKB/Swiss-Prot;Acc:G5ECQ8])

HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0
Identity = 303/760 (39.87%), Postives = 472/760 (62.11%), Query Frame = 1 
Query: 1303 QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDA--GKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALK-KEHR-----IFDEDPVKKGIFEES--------------YDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRS 3498
            + M ++ +  PK  RK + +  I KL+DA  AGTK S +CTLILTEGDSAK+ A+SGL V+G+D +GVF  + K LN  ++   ++  + +   ++  LG+ Y KKY T++  K+LRYGK++IMA+ D DGS  KGL+LNFFH  WP L + DF E FITPI KA +  + + FYS   Y  W   T ++  + IKYY GLGT TS EAK+ F ++ +HR  F Y+G++DD  + M F +++   R +++++ ++ +    ++ + EE ++ K    ++ KDF N E++   N   + +IP ++DGLKP QRK+++ C KR   ++VKV QL+G+V+E++ YHH E+S+  T+++LAQDYVGS+NINLL+P+G FGTR+ GGKD+ASAR I  +LS + R +FPA DDN L+  Y++NQ IEP WY PIIP VL+NGA G GTGW T IPNYNP ++++N++ L+  +P   + PWY+NF+G I + D  ++   G+  +L+  T+E+ ELPI   TQ YKE ++  ++ +S     ++ DY++ +TDT V+F++ L   KL   E   +L Q+  L + I+TT MVLFD    ++ Y++P  I  EF+ +R   Y +RK++ +  + A++K+  NQ RFI      K+ L N  +     +L +  FD+DP+K W++  K KE R       DED +     EE                D+ YL+ + +   ++++   L    + K+ E  +L +++
Sbjct:   20 KQMDDLNQKCPK--RKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDLNVNQIADSAEVNAIIKILGLQYTKKYETEDDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVEDFITPIAKATEGKEEVSFYSLPEYSEWRMNTDNWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFSKKKIEARTDYLMKLMQDKNQRKQQGLAEECLYNKETRFVTLKDFFNYEIVCSWN---LHSIPCLVDGLKPGQRKVLFACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILATINNKIVLENKKKTAIVDVLIKMKFDADPVKKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKAVETKLSDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKT 774
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: R05D3.12 (Putative DNA topoisomerase 2, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P34534])

HSP 1 Score: 533.487 bits (1373), Expect = 4.179e-174
Identity = 304/726 (41.87%), Postives = 453/726 (62.40%), Query Frame = 1 
Query:   76 LKYFNNISHSLSI-----RCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSIN-KSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEP-VIE--KAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNL-KNVSIYFNDTQIPITSFKQYVELYDNNDS-QFIHNTINNSLEVAVT---LSTSYSFTQ--ISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIID-CGLLERI-QSMMNM-KKDFPKSLRKVNNILDIVKLDDALHAG-TKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKK-YLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQD 2187
            LK+  + SH  ++     R   +N+P+T  S   E   K Y+KK+  EH+L RPD+Y+G +  +  +  W+ D    K+I KE+ Y P L KIFDEILVNA+DNK RD  M+ +++ ++R+   IS+ N+GSG+PV +H TE +Y+PTL+FGNL TSSNYDDS  K  GGRNG+GAKLCN+FSK F VET       R++Q W +NM +  E  V+E       D+T + F PDL RF++D L  D+I L  RR F++A+ L ++V +Y N  +  +  F+ YV++++++ S  F+H T    + VA        S+      +SFVN INT  GG HV+  ++K+V ++    ++ + +  K ++P  IKN+L IF+N ++ NP FESQ+KE LT+    F S      K      +  GL+E I + ++NM KK  P     V+++ DIVKL+DA  AG T  + +CTLILTEGDSAK+ A++GL+VLG++ +GVF L+GK LN  N+ + +   N++  +++  LG+ ++    +T+E   SLRYG+++I+ADQD DGSHIKGLI+NF H  WP L+  D F + F TP++KA K  +   F+S N Y+ W     +  KW+IKYYKGLGTSTS EA+EYF ++D H  +F Y+G+ DD  ++M F+R++S +RKEWI     +R      N D+       KT ISY++F++ +L+ +   D
Sbjct:   10 LKFCISTSHRTTVVLKNTRSFCNNIPST--SFASEAAAK-YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRE---SLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADV-EEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWI-----RRSENEITNEDD------GKTEISYQEFVDGQLMQFGMVD 717
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: R05D3.12 (Putative DNA topoisomerase 2, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P34534])

HSP 1 Score: 533.487 bits (1373), Expect = 4.179e-174
Identity = 304/726 (41.87%), Postives = 453/726 (62.40%), Query Frame = 1 
Query:   76 LKYFNNISHSLSI-----RCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSIN-KSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEP-VIE--KAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNL-KNVSIYFNDTQIPITSFKQYVELYDNNDS-QFIHNTINNSLEVAVT---LSTSYSFTQ--ISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIID-CGLLERI-QSMMNM-KKDFPKSLRKVNNILDIVKLDDALHAG-TKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKK-YLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQD 2187
            LK+  + SH  ++     R   +N+P+T  S   E   K Y+KK+  EH+L RPD+Y+G +  +  +  W+ D    K+I KE+ Y P L KIFDEILVNA+DNK RD  M+ +++ ++R+   IS+ N+GSG+PV +H TE +Y+PTL+FGNL TSSNYDDS  K  GGRNG+GAKLCN+FSK F VET       R++Q W +NM +  E  V+E       D+T + F PDL RF++D L  D+I L  RR F++A+ L ++V +Y N  +  +  F+ YV++++++ S  F+H T    + VA        S+      +SFVN INT  GG HV+  ++K+V ++    ++ + +  K ++P  IKN+L IF+N ++ NP FESQ+KE LT+    F S      K      +  GL+E I + ++NM KK  P     V+++ DIVKL+DA  AG T  + +CTLILTEGDSAK+ A++GL+VLG++ +GVF L+GK LN  N+ + +   N++  +++  LG+ ++    +T+E   SLRYG+++I+ADQD DGSHIKGLI+NF H  WP L+  D F + F TP++KA K  +   F+S N Y+ W     +  KW+IKYYKGLGTSTS EA+EYF ++D H  +F Y+G+ DD  ++M F+R++S +RKEWI     +R      N D+       KT ISY++F++ +L+ +   D
Sbjct:   10 LKFCISTSHRTTVVLKNTRSFCNNIPST--SFASEAAAK-YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRE---SLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADV-EEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWI-----RRSENEITNEDD------GKTEISYQEFVDGQLMQFGMVD 717
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Fly
Match: Top2 (gene:FBgn0284220 transcript:FBtr0332320)

HSP 1 Score: 999.964 bits (2584), Expect = 0.000e+0
Identity = 527/1165 (45.24%), Postives = 753/1165 (64.64%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNN---DS----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKY---IRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK--DFPKSL-RKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWI---LQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS----KSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQ-----LLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQAL--------------------------KKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +IE+ YQKK+ +EHIL RPDSY+GS+  + +  W++D SQN++++KEI +VP L+KIFDEILVNA+DNK+RD  M+ IKI+++ + N +S+ N+G GIPV +H  + MY+PT+IFG+LLTSSNY+D  +K TGGRNG+GAKLCN+FS SF+VET++      +KQTW NNM + ++  I+   G D+T ITF PDL +FKMD LD DI+AL  RRA+D+A++ K VS++ N  ++ + +FK Y++L+  N   DS    + +H   N   EVA   S    F Q+SFVN I T  GG HV+  V+ L++ L++    ++K+  K    I+P Q++N LW+FVN ++ NP F+SQ+KE +T     F S+  LS+KF+NN+   G++E + +    K   D  K+  RK + I  I KL+DA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    +++  N +  ++   +G+ YKKKYLT++ LK+LRYGKVMIM DQD DGSHIKGL++NF H NWPELL+L F E+FITPI+KA K  + + FYS   ++ W   T ++  + IKYYKGLGTSTS EAKEYF+++D+HR  F Y GS DD  + M F ++    RK W+   +  +K+RK L    + E  ++ K   SI+Y DFIN EL+++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QLSGSV+E++ YHH E S+  T+++LAQ++VG+NNINLL P G FGTR+ GGKD ASARYI T +SP+ R I+   DD  L  + DD Q IEP+WY PIIP VL+NGA G+GTGW T I NYNP +I++NLR ++N + P  M PWY+NF G +      +Y  TG  +IL+   LE+ ELP+G+ TQ YKE ++ E L N     K I+ +Y + +TDT VRF+I       E R++ ++     +  L++ +ST  M  FD+++ ++R+ T ++IL E++K R   Y +R+D  V ++ A+A +  +Q RFI  K   KL + N         L +  +  DP+K W++ +                          KKE  +  E   KK    +   F YLL M +   T++K   L     +KL E E L +++P
Sbjct:    9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPS-DRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLE----VLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKEL---GLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVL-EPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFE-RIHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKK--LTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTP 1161
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Fly
Match: Top2 (gene:FBgn0284220 transcript:FBtr0081287)

HSP 1 Score: 999.964 bits (2584), Expect = 0.000e+0
Identity = 527/1165 (45.24%), Postives = 753/1165 (64.64%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNN---DS----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKY---IRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK--DFPKSL-RKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWI---LQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS----KSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQ-----LLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQAL--------------------------KKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +IE+ YQKK+ +EHIL RPDSY+GS+  + +  W++D SQN++++KEI +VP L+KIFDEILVNA+DNK+RD  M+ IKI+++ + N +S+ N+G GIPV +H  + MY+PT+IFG+LLTSSNY+D  +K TGGRNG+GAKLCN+FS SF+VET++      +KQTW NNM + ++  I+   G D+T ITF PDL +FKMD LD DI+AL  RRA+D+A++ K VS++ N  ++ + +FK Y++L+  N   DS    + +H   N   EVA   S    F Q+SFVN I T  GG HV+  V+ L++ L++    ++K+  K    I+P Q++N LW+FVN ++ NP F+SQ+KE +T     F S+  LS+KF+NN+   G++E + +    K   D  K+  RK + I  I KL+DA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    +++  N +  ++   +G+ YKKKYLT++ LK+LRYGKVMIM DQD DGSHIKGL++NF H NWPELL+L F E+FITPI+KA K  + + FYS   ++ W   T ++  + IKYYKGLGTSTS EAKEYF+++D+HR  F Y GS DD  + M F ++    RK W+   +  +K+RK L    + E  ++ K   SI+Y DFIN EL+++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QLSGSV+E++ YHH E S+  T+++LAQ++VG+NNINLL P G FGTR+ GGKD ASARYI T +SP+ R I+   DD  L  + DD Q IEP+WY PIIP VL+NGA G+GTGW T I NYNP +I++NLR ++N + P  M PWY+NF G +      +Y  TG  +IL+   LE+ ELP+G+ TQ YKE ++ E L N     K I+ +Y + +TDT VRF+I       E R++ ++     +  L++ +ST  M  FD+++ ++R+ T ++IL E++K R   Y +R+D  V ++ A+A +  +Q RFI  K   KL + N         L +  +  DP+K W++ +                          KKE  +  E   KK    +   F YLL M +   T++K   L     +KL E E L +++P
Sbjct:    9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPS-DRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLE----VLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKEL---GLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVL-EPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFE-RIHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKK--LTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTP 1161
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2b (DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GENE-041008-136])

HSP 1 Score: 1045.8 bits (2703), Expect = 0.000e+0
Identity = 526/1136 (46.30%), Postives = 755/1136 (66.46%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDP-------VKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEM 3483
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+     + +EI +VP L+KIFDEILVNA+DNK+RD  M+ IKI ++ + N IS+ N+G GIPVV H  E MY+P LIFG+LLTSSNYDD+ +K TGGRNG+GAKLCN+FS  F+VET+ +     +KQTWT NM +  E  I+   G DFT +TF+PDL +F M+ LD DI+AL  RRA+D+A + + V +  N  ++P+ SF+ YV+ Y  D  D      + ++ T+N   EV +T+S    F QISFVN I T  GG H++  V+++V  L++  +   K     ++P Q+KN LW+FVN+++ NP F+SQ+KE +T     F S+  LS+KF+    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  LG+ YKK Y   ESLKSLRYG++MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T  Y  W IKYYKGLGTSTS EAKEYF ++++HR  F Y+G+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++  +   +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TC+KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D + L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +LN + P+ M+P Y+NFKG+I+E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML     +  ++ DY++ +TDT V+F++ +   KL   E    L ++  L S ++  +MVLFD    +KRY +  EIL EFF+ RL  Y+ RKD  V  + AE+ K  NQ RF+  K  GKL++ N ++ +   +L Q  ++SDP+  W +A  +E  + +ED                  +F Y+LNMP+   TK+K+E L  L +  L +AE+
Sbjct:   49 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNL-REISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDNEKKVTGGRNGYGAKLCNIFSLKFTVETACKEYKRSFKQTWTENMGKSNEAKIKYFDGEDFTCVTFQPDLAKFNMEKLDKDIVALLTRRAYDVAGSCRGVKVILNGKKLPVNSFRSYVDFYVKDKLDETGVALKVVNETVNERWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYIVDQIVGKLIEVVKKKNKAGVS-VKPFQVKNHLWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKILGLQYKKSYDDPESLKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSSLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGTIHELGQNQYLVSGEVSVLDKNTIEISELPVRTWTQAYKESVLEPMLQGTDKTPPLISDYKEYHTDTTVKFVVRMTEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQEILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKLSIENKSKRDLIRMLVQRGYESDPVAAWNKA--QEKSLEEEDGGGNDSDSSVDSGSFSGPNFNYILNMPLWCLTKEKVEEL--LKQRDLKKAEL 1172
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453])

HSP 1 Score: 1008.82 bits (2607), Expect = 0.000e+0
Identity = 522/1137 (45.91%), Postives = 737/1137 (64.82%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDSQF--IHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHLKLD-LKEIR-LNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+    +  ++I +VP L+KIFDEILVNA+DNK+RD  M+ IK+N++ + N IS+ N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+   +   +KQTW +NM +  E  I+   G D+T ITF+PDL +FKM  LD D +AL  RRA+DIA + K V +  N  ++PI +F+ YV+LY     D   S    +H  +N   EV +TLS    F Q+SFVN I T  GG H +   +++V  L+   E + K++     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T     F S   LSDKFV     CG++E I        Q+ +N K     S  K   I  + KLDDA  AG K S  CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  LG+ YKK Y   ESLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+KA    Q I FYS   +  W +       W+IKYYKGLGTSTS EAKEYF ++ +HR  F YSG  DD  + + F ++   +RKEW+  ++  R+   + N+ EE ++ +   S+SY DFINKEL+++SN DN R+IP ++DGLKP QRK+++ C KRN  ++VKV QL+GSV+E++ YHH E S+  T++ LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP  DDN L+  YDDN  +EP WY PIIP VL NG  G+GTGW + IPNY+  +II N+  +LN + P+ M+P Y+ FKG+I+E  + +Y   G+  I++S T+E+ ELP+   TQ YKE ++  ML  ++   +++ DY++ +TDT VRF++ +  + L+E     L ++  L + ++  +MVLFD    +K+Y +  +IL EFF+ R+  Y  RKD  V  + AE+ K  NQ RFI  K  G L + N  + E   +L+Q  +DSDP+K W+ A +KE     ED  +K   + S  D+ YLL+MP+   TK+K + L     +K+ E   L  ++P
Sbjct:   28 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEDTG-MNCRDITFVPGLYKIFDEILVNAADNKQRDKTMNCIKVNIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETACRESKRCFKQTWFDNMGRAGESKIKPFDGDDYTCITFQPDLAKFKMQALDKDTVALLTRRAYDIAGSTKGVRVLLNGKRLPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEK-GFQQVSFVNSIATTKGGRHTDYVADQIVSKLI---EVVKKKNKAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKFKAQAQLNKKC----SAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYSDPESLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKQEISFYSIPEFTEWKEKQSSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLAFSKKMIEERKEWLTSFMINRRQRREHNLPEEYLYGQETKSLSYHDFINKELVLFSNSDNERSIPCMVDGLKPGQRKVVFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKENVLEVMLNGTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYDSDPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAP 1155
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453])

HSP 1 Score: 294.664 bits (753), Expect = 2.175e-84
Identity = 165/394 (41.88%), Postives = 247/394 (62.69%), Query Frame = 1 
Query: 2344 SIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHLKLD-LKEIR-LNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            S+  T++ LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP  DDN L+  YDDN  +EP WY PIIP VL NG  G+GTGW + IPNY+  +II N+  +LN + P+ M+P Y+ FKG+I+E  + +Y   G+  I++S T+E+ ELP+   TQ YKE ++  ML  ++   +++ DY++ +TDT VRF++ +  + L+E     L ++  L + ++  +MVLFD    +K+Y +  +IL EFF+ R+  Y  RKD  V  + AE+ K  NQ RFI  K  G L + N  + E   +L+Q  +DSDP+K W+ A +KE     ED  +K   + S  D+ YLL+MP+   TK+K + L     +K+ E   L  ++P
Sbjct:    2 SLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKENVLEVMLNGTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYDSDPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAP 395
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2b (DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GENE-041008-136])

HSP 1 Score: 107.071 bits (266), Expect = 1.894e-26
Identity = 49/96 (51.04%), Postives = 70/96 (72.92%), Query Frame = 1 
Query:  169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSG 456
            +E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+     + +EI +VP L+KIFDEILVNA+DNK+RD  M+ IKI ++ + N IS+ N+G G
Sbjct:   45 VERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNL-REISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKG 139
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457])

HSP 1 Score: 1043.49 bits (2697), Expect = 0.000e+0
Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +S W++D+    +  ++I YVP L+KIFDEILVNA+DNK+RD  M+ IKI+++ D N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTWTNNM + TEP I+   G D+T ITF+PDL +F+M+ LD D +AL  RRA+DIA + K V +  N  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T +   W+IKYYKGLGTSTS EAKEYF ++D+HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   +PNY+  +I+ N++ +L+   P  ++P Y+NFKG+I E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML  ++   S++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  +  + AEA +  NQ RF+  K  GK+++ N  + +   +L Q  F+SDP+K W++A +K     D     ED           DF Y+LNM + S +K+K++ L      K  E   L R+SP
Sbjct:   97 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1228
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457])

HSP 1 Score: 1043.11 bits (2696), Expect = 0.000e+0
Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +S W++D+    +  ++I YVP L+KIFDEILVNA+DNK+RD  M+ IKI+++ D N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTWTNNM + TEP I+   G D+T ITF+PDL +F+M+ LD D +AL  RRA+DIA + K V +  N  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T +   W+IKYYKGLGTSTS EAKEYF ++D+HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   +PNY+  +I+ N++ +L+   P  ++P Y+NFKG+I E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML  ++   S++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  +  + AEA +  NQ RF+  K  GK+++ N  + +   +L Q  F+SDP+K W++A +K     D     ED           DF Y+LNM + S +K+K++ L      K  E   L R+SP
Sbjct:   47 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1178
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457])

HSP 1 Score: 1042.72 bits (2695), Expect = 0.000e+0
Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +S W++D+    +  ++I YVP L+KIFDEILVNA+DNK+RD  M+ IKI+++ D N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTWTNNM + TEP I+   G D+T ITF+PDL +F+M+ LD D +AL  RRA+DIA + K V +  N  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T +   W+IKYYKGLGTSTS EAKEYF ++D+HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   +PNY+  +I+ N++ +L+   P  ++P Y+NFKG+I E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML  ++   S++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  +  + AEA +  NQ RF+  K  GK+++ N  + +   +L Q  F+SDP+K W++A +K     D     ED           DF Y+LNM + S +K+K++ L      K  E   L R+SP
Sbjct:   51 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1182
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457])

HSP 1 Score: 1041.95 bits (2693), Expect = 0.000e+0
Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +S W++D+    +  ++I YVP L+KIFDEILVNA+DNK+RD  M+ IKI+++ D N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTWTNNM + TEP I+   G D+T ITF+PDL +F+M+ LD D +AL  RRA+DIA + K V +  N  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T +   W+IKYYKGLGTSTS EAKEYF ++D+HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   +PNY+  +I+ N++ +L+   P  ++P Y+NFKG+I E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML  ++   S++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  +  + AEA +  NQ RF+  K  GK+++ N  + +   +L Q  F+SDP+K W++A +K     D     ED           DF Y+LNM + S +K+K++ L      K  E   L R+SP
Sbjct:   47 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1178
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457])

HSP 1 Score: 1036.17 bits (2678), Expect = 0.000e+0
Identity = 529/1142 (46.32%), Postives = 753/1142 (65.94%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFD--EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +S W++D+    +  ++I YVP L+KIFDEILVNA+DNK+RD  M+ IKI+++ D N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTWTNNM + TEP I+   G D+T ITF+PDL +F+M+ LD D +AL  RRA+DIA + K V +  N  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T +   W+IKYYKGLGTSTS EAKEYF ++D+HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E ++  T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   +PNY+  +I+ N++ +L+   P  ++P Y+NFKG+I E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML  ++   S++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  +  + AEA +  NQ RF+  K  GK+++ N  + +   +L Q  F+SDP+K W++A +K     E  + D  ED           DF Y+LNM + S +K+K++ L      K  E   L R+SP
Sbjct:    2 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEVTLMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEAA-GLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKVGATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1135
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Match: Top2a (topoisomerase (DNA) II alpha [Source:MGI Symbol;Acc:MGI:98790])

HSP 1 Score: 1038.48 bits (2684), Expect = 0.000e+0
Identity = 528/1140 (46.32%), Postives = 753/1140 (66.05%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK------EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +IE+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+S      +KQTW +NM +  +  ++   G D+T ITF+PDL++FKM +LD DI+AL  RRA+DIA + K+V ++ N   +P+  F+ YV+LY         N  + IH  +N   EV +T+S    F QISFVN I T  GG HV+   +++V  LV     ++K+  K    ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T     F S   LS+KF+   I CG++E I + +  K         S  K   I  I KLDDA  AG++ S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+K  K+ Q I FYS   ++ W  +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F ++Q   RKEW+  +++ R+      + E+ ++ ++ + ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP  DD+ L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  +++ N+R LL+ + P+ M+P Y+NFKG+I E    +Y   G+  IL+S T+E+ ELPI   TQ YKE ++  ML  ++   S++ DY + +TDT V+F+I +   KL   E R+ L ++  L S ++  +MVLFD    +K+Y T ++IL +FF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  +DSDP+K W++A +K            E        E    F YLL+MP+   TK+K + L      K  E   L ++SP
Sbjct:   28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMS-ERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAE-RVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSP 1160
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Match: Top2b (topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791])

HSP 1 Score: 1029.62 bits (2661), Expect = 0.000e+0
Identity = 533/1177 (45.28%), Postives = 760/1177 (64.57%), Query Frame = 1 
Query:   55 LASSRYLLKYFNNISHSLSIRCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            LA S   L + NN +    +     N   +TK L   ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    +  +E+ +VP L+KIFDEILVNA+DNK+RD  M+ IK++++ + N ISI N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNM + +E  I+   G D+T ITF+PDL++FKM+ LD DI+AL  RRA+D+A + K V + FN  ++P+  F+ YV+LY  D  D      + IH   N   +V +TLS    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+F+N ++ NP F+SQ+KE +T  P  F S+  LS+KF     +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+KA K+ Q + FYS   +  W K   +   W+IKYYKGLGTST+ EAKEYF ++++HR  F Y+G EDD  + + F +++   RKEW+  +++ R+      + E+ ++      ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   +PNY+  +I+ N+R +L    P  M+P Y+NFKG+I E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +MVLFD    +K+Y T  +IL EFF  RL  Y  RK+  V  + AE+ K  NQ RFI  K  GK+ + N ++ +   +L Q  ++SDP+K W++A +K     D     +D           DF Y+LNM + S TK+K+E L     +K  E   L R+SP
Sbjct:    6 LAGSDGALTWVNNATKKEELETANKN--DSTKKL---SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSP 1169
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Match: Top2b (topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791])

HSP 1 Score: 108.612 bits (270), Expect = 7.439e-26
Identity = 56/160 (35.00%), Postives = 96/160 (60.00%), Query Frame = 1 
Query: 2605 INGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSE 3066
            INGA G+GTGW   +PNY+  +I+ N+R +L    P  M+P Y+NFKG+I E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML  +    +++ DY++ +TDT V+F++ +   KL   E    L ++  L + ++  +M   +E S+
Sbjct:    2 INGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMAAEEEDSQ 160
[Close]
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|O46374|TOP2A_PIG (DNA topoisomerase 2-alpha OS=Sus scrofa OX=9823 GN=TOP2A PE=2 SV=1)

HSP 1 Score: 1046.96 bits (2706), Expect = 0.000e+0
Identity = 531/1142 (46.50%), Postives = 758/1142 (66.37%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +IE+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+S      +KQTW +NM +  E  ++   G D+T ITF PDL++FKM +LD DI+AL  RRA+DIA + K+V ++ N  ++P+  F+ YV+LY         N  + IH  +N+  EV +T+S    F QISFVN I T  GG HV+   +++V  LV     ++K+  K    ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T     F S   LS+KF+   I CG++E I + +  K         S  K N I  I KLDDA  AG + S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+K  K+ Q + FYS   ++ W  +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F ++Q   RKEW+  +++ R+      + E+ ++ +  T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP  DD+ L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  +++ N+RLL++ + P+ M+P Y+NFKG+I E    +Y  +G+  ILNS T+E+ ELPI   TQ YKE ++  ML  ++    ++ DY + +TDT V+F++ +   KL   E R+ L ++  L + ++  +MVLFD    +K+Y T ++IL +FF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  +DSDP+K W++A +K     + +        +  D        F YLL+MP+   TK+K + L  L   K  E E L R+SP
Sbjct:   29 SIERIYQKKTQLEHILLRPDTYIGSVESVTQQMWVYDEDIG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFHPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDLYLKDKVDETGNPLKIIHEQVNHRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVAKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRLLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKEADKSDSVADSGPTFNYLLDMPLWYLTKEKKDELCKLRNEKEQELETLKRKSP 1163
[Close]
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|O42130|TOP2A_CHICK (DNA topoisomerase 2-alpha OS=Gallus gallus OX=9031 GN=TOP2A PE=2 SV=2)

HSP 1 Score: 1043.49 bits (2697), Expect = 0.000e+0
Identity = 525/1146 (45.81%), Postives = 760/1146 (66.32%), Query Frame = 1 
Query:  133 LPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            LP    +    ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+    +  +++ +VP L+KIFDEILVNA+DNK+RD  MS IK+ ++ + N IS+ N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+       +KQTWT+NM +  E  ++   G D+T +TF+PDL++FKM  LD DI+AL  RRA+DIA + K+V ++ N  ++P+  F+ YV+LY         N  + IH  +N+  EV +TLS    F Q+SFVN I T  GG HV+   +++V  L+   +   K +   ++P Q+KN +WIFVNS++ NP F+SQ+KE +T     F S   LS+KF+   + CG++E I        Q+ +N K     S  K   I  + KLDDA  AG+K S +CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  +ESLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+K  K+ + IPFYS   ++ W  +T +Y+ W+IKYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F +++  +RKEW+  +++ R+      + E+ ++ K+   ++Y DFINKEL+++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VK  QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP  DDN L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  + + N+R LL+ K P+ M+P Y+NFKG+I+E    +Y  +G+  IL+S T+E+ ELP+   TQ YKE ++  ML  ++    ++ DY++ +TDT V+F++ +   KL   E  + L ++  L + ++  +MVLFD    +K+Y +P +IL EFF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  ++SDP+K W++ L+ +     ++  ++       DF YLLNMP+   TK+K + L     +K  E E L  +SP
Sbjct:   19 LPKADGAQKRLSVERIYQKKTQLEHILLRPDTYIGSVETVTQQMWVFDEDVG-LNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVTIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACREYKKLFKQTWTDNMGKAGEMTLKHFDGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIAGSTKDVKVFLNGKRLPVKGFRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEK-GFQQVSFVNSIATTKGGRHVDYVADQIVTKLIDVVKKKNK-NGVGVKPFQVKNHMWIFVNSLIENPTFDSQTKENMTLQAKSFGSTCKLSEKFIKGAVGCGIVESILNWVKFKAQTQLNKKC----SAVKHTKIKGVPKLDDANDAGSKNSIDCTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKMLNVREASHKQIMENAEINNIIKIVGLQYKKNYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSKNKEEIPFYSIPEFEEWKSSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPEDDAAITLAFSKKKVEERKEWLTNFMEDRRQRNVHGLPEDYLYGKDTNYLTYNDFINKELVLFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKGAQLAGSVAEMSSYHHGEASLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDNVLRFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRCLLDGKEPLPMLPSYKNFKGTIDELGPNQYVISGEVSILDSTTIEITELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYKEYHTDTTVKFVVKMSEEKLAEAEA-VGLHKVFKLQTNLTCNSMVLFDHVGFLKKYESPQDILKEFFELRLRYYGLRKEWLIGMLGAESAKLNNQARFILEKIDGKIVIENKPKKELIQVLIQRGYESDPVKAWKE-LQNKEEEEGDESGEESAAATGPDFNYLLNMPLWYLTKEKKDELCKQRDNKDKELEDLKHKSP 1155
[Close]
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|P11388|TOP2A_HUMAN (DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3)

HSP 1 Score: 1041.57 bits (2692), Expect = 0.000e+0
Identity = 528/1142 (46.23%), Postives = 758/1142 (66.37%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+S      +KQTW +NM +  E  ++   G D+T ITF+PDL++FKM +LD DI+AL  RRA+DIA + K+V ++ N  ++P+  F+ YV++Y         N  + IH  +N+  EV +T+S    F QISFVN I T  GG HV+   +++V  LV     ++K+  K    ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T  P  F S   LS+KF+   I CG++E I + +  K         S  K N I  I KLDDA  AG + S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+K  K+ Q + FYS   ++ W  +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F ++Q   RKEW+  +++ R+      + E+ ++ +  T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP  DD+ L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  +I+ N+R L++ + P+ M+P Y+NFKG+I E    +Y  +G+  ILNS T+E+ ELP+   TQ YKE ++  ML  ++    ++ DY + +TDT V+F++ +   KL   E R+ L ++  L + ++  +MVLFD    +K+Y T ++IL +FF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  +DSDP+K W++A +K     + +        E  D        F YLL+MP+   TK+K + L  L   K  E + L R+SP
Sbjct:   29 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVTKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSP 1163
[Close]
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|Q01320|TOP2A_MOUSE (DNA topoisomerase 2-alpha OS=Mus musculus OX=10090 GN=Top2a PE=1 SV=2)

HSP 1 Score: 1038.48 bits (2684), Expect = 0.000e+0
Identity = 528/1140 (46.32%), Postives = 753/1140 (66.05%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK------EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +IE+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+S      +KQTW +NM +  +  ++   G D+T ITF+PDL++FKM +LD DI+AL  RRA+DIA + K+V ++ N   +P+  F+ YV+LY         N  + IH  +N   EV +T+S    F QISFVN I T  GG HV+   +++V  LV     ++K+  K    ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T     F S   LS+KF+   I CG++E I + +  K         S  K   I  I KLDDA  AG++ S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+K  K+ Q I FYS   ++ W  +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F ++Q   RKEW+  +++ R+      + E+ ++ ++ + ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP  DD+ L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  +++ N+R LL+ + P+ M+P Y+NFKG+I E    +Y   G+  IL+S T+E+ ELPI   TQ YKE ++  ML  ++   S++ DY + +TDT V+F+I +   KL   E R+ L ++  L S ++  +MVLFD    +K+Y T ++IL +FF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  +DSDP+K W++A +K            E        E    F YLL+MP+   TK+K + L      K  E   L ++SP
Sbjct:   28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMS-ERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAE-RVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSP 1160
[Close]
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|P41515|TOP2A_CRIGR (DNA topoisomerase 2-alpha OS=Cricetulus griseus OX=10029 GN=TOP2A PE=1 SV=1)

HSP 1 Score: 1038.1 bits (2683), Expect = 0.000e+0
Identity = 527/1138 (46.31%), Postives = 756/1138 (66.43%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +IE+ YQKKT +EHIL RPD+Y+GS+    +  W++D+    I  +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H  E MY+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+S+     +KQTW +NM +  +  ++   G D+T ITF+PDL++FKM +LD DI+AL  RRA+DIA + K+V ++ N  ++P+  F+ YV++Y         N  + +H  +N   EV +T+S    F QISFVN I T  GG HV+   +++V  LV     ++K+  K    ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T     F S   LS+KF+   I CG++E I + +  K         S  K N I  I KLDDA  AG++ S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y  ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+  F E+FITPI+K  K+ Q + FYS   ++ W  +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F ++Q   RKEW+  +++ R+      + E+ ++ +  T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GSV+E+++YHH E S+  T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP  DD+ L+  YDDNQ +EP WY PIIP VLINGA G+GTGW   IPN++  +++ N+R LL+ + P+ M+P Y+NFKG+I E    +Y   G+  ILNS T+E+ ELPI   TQ YKE ++  ML  ++    ++ DY + +TDT V+F+I +   KL   E R+ L ++  L + ++  +MVLFD    +K+Y T ++IL +FF+ RL  Y  RK+  +  + AE+ K  NQ RFI  K  GK+ + N  + E   +L Q  +DSDP+K W++A +K    E     ++     + E    F YLL+MP+   TK+K + L      K  E   L  +SP
Sbjct:   28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVETASKEYKKMFKQTWMDNMGRAGDMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNALKVVHEQVNPRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVSKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQELAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILKDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNENSDSVAESGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKNKSP 1158
[Close]
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A5K3ERS3 (DNA topoisomerase 2 OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 1069.69 bits (2765), Expect = 0.000e+0
Identity = 528/1153 (45.79%), Postives = 775/1153 (67.22%), Query Frame = 1 
Query:  136 PTTTKSLILE-NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLE------RIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSI---VRDYEDRNTDTEVRFIIHLKLD-LKEIR-LNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK---------------EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLN 3489
            P  TKS     ++E+ YQKKT +EHIL RPD+Y+GS+++S    W+FDK +  +++KEI Y P L+KI+DEILVNA+DNK RD  M+ I+I++  +EN + I N+G+GIPVV H  ENMY+P+LIFG+LLTSSNYDD+ +K TGGRNG+GAKLCN+FSK F VETSS+     +KQTW +NMT+ +EP I+   G DFT I+F+PDL RF M  LD D +ALF RRA+D+A++ + V ++ N  +IPI SFK YV+LY      D +    ++ ++N   E+AV  S++  F Q+SFVN I T+ GG HV+   +++V  LV   +    +    I+  QI++ +W+F+N ++ NP F+SQ+KE+++     F S   LS+KF+N +   G++E      R ++   M K   KS  K   +  I KLDDA  AGTK S  CTLILTEGDSAKS A++GL V+G+D +GVF L+GK LN R    R+++ N +  +++  LG+ YK KY T+ESL +LRYGK+MIM DQD DGSHIKGLI++F HHNWP+LL  +F EQFITPI+K FK  Q I FYS   ++ W KATP++  WR+KYYKGLGTS+S EAKEYF ++ +HR  F YSG EDD  + + F + +  +RK+W+  W+++++   +  + E+ ++     +++Y DFI+KEL+++SN DN R+IPS++DGLKP QRK+++TCLKRN +K++KV QL G+VSE+++YHH E S+  T++ LAQD+VGSNN+NLL+P G FGTR+ GGKD+ASARYI T LSP+ R IF   DD  L   ++DNQ IEP WY P+IP VLINGA G+GTGW T +PNY+  ++I N+R +L+   P+ M+P YR ++G I E  + +Y   G+  +L+ +T+E+ ELP+ + TQ YKE ++  ML  ++ +   + DY++ +TD  VRF++ +  + L+E   + L +   L+  ++T +MVLFD    +KRY++  EIL +F+K RL  YEKRK      + +EA++ ENQ RF+  K A K+ + N ++ E   LL++  +D DP++ W++++ K               E  + DE+ V +     + D+ Y+L MP+ S +K++ ++L  L +    +AE+ N
Sbjct:   17 PVQTKSPRKRLSVERIYQKKTQLEHILIRPDTYIGSVSRSATMMWVFDKEKQSMVQKEITYTPGLYKIYDEILVNAADNKIRDPTMNCIRIDIKPEENLVRIWNNGAGIPVVHHKVENMYVPSLIFGHLLTSSNYDDTEQKVTGGRNGYGAKLCNIFSKRFVVETSSKDNKKSFKQTWVDNMTKTSEPQIKVNSGEDFTCISFQPDLNRFGMTELDADTVALFERRAYDVAASTRGVKVFLNGQRIPIKSFKDYVDLYLKDKGEDGDAVPVVYESVNPRWEIAVAPSST-GFQQVSFVNSIATIKGGKHVDYIADQVVGKLVDIVKKKSGKSGVAIKNFQIRSHMWVFINCLIVNPTFDSQTKEFMSLEAKNFGSVCQLSEKFINQVSKSGIVESILSWVRFKAQEKMDKQCHKS--KHAKLKGIPKLDDANDAGTKNSQHCTLILTEGDSAKSLAVAGLGVVGRDRYGVFPLRGKLLNVREAPTRQIMENAEINNLIKILGLQYKNKYETQESLANLRYGKIMIMTDQDQDGSHIKGLIISFIHHNWPKLLHHNFLEQFITPIVKIFKGKQEIAFYSIPEFEEWQKATPNWHTWRVKYYKGLGTSSSKEAKEYFSDMTRHRIRFRYSGPEDDSGIVLAFNKNKINERKQWLTSWMEEKRRRTELGLPEDYLYGAGTHTVTYHDFIHKELVLFSNMDNERSIPSLVDGLKPGQRKVMFTCLKRNQVKEIKVAQLCGAVSEMSSYHHGEMSLMGTIVGLAQDFVGSNNLNLLMPYGQFGTRLSGGKDSASARYIFTALSPLTRKIFHENDDAILHYLFEDNQKIEPSWYIPVIPMVLINGAEGIGTGWSTKVPNYDTAEVIANIRRMLDGVDPLPMLPSYRGYRGKIVEVGENRYILFGEIAVLDDQTVEITELPVRVWTQSYKETVLEPMLNGTEKVPVSITDYKEYHTDVTVRFVVQMPREKLREAESVGLHKFFKLAVSLTTNSMVLFDHAGCLKRYTSAQEILKDFYKLRLEWYEKRKAFMEGMLSSEARRLENQARFVMEKIADKVTIENKSKKELLRLLRERHYDPDPVRAWKESIDKLAAIEDAAAARRQAGEPEVGDEEDVDQA--SGTADYNYILGMPLWSLSKERKDDL--LAQRDKKQAELTN 1162
[Close]
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A5C6NGH8 (DNA topoisomerase 2 OS=Takifugu flavidus OX=433684 GN=D4764_21G0008480 PE=3 SV=1)

HSP 1 Score: 1069.3 bits (2764), Expect = 0.000e+0
Identity = 537/1140 (47.11%), Postives = 762/1140 (66.84%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK---EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+    + ++EI YVP L+KIFDEILVNA+DNK+RD  M+ IKI+++ + N ISI N+G GIPVV H  E MY+P LIFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNMT+  +P ++   G DFT +TF+PDL++FKM+ LD DIIAL  RRA+D+A + K V +  N  ++P+  F+ YV+LY  D  D      + ++ T+N   EV +TLS    F QISFVN I T  GG H++  V+++V  L+   E + K++     ++P Q+KN +W+FVN+++ NP F+SQ+KE +T     F S+  LSDKF+    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   ++ W K T +Y  W IKYYKGLGTSTS EAKEYF  +++HR +F YSG+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++      +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FP  D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+  +I+ N+  +LN + P+QM+P Y+NFKG I+E  Q +Y  +G+  +++  T+EV ELP+   TQ YKE ++  ML  S    +++ DY++ +TDT V+F++ +   KL   E  + L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL  Y+ RKD  V  + AEA K  NQ RF+  K  GK+++ N ++ E   +L Q  F+SDP+  W +A +K   E    + D           +F Y+LNMP+   TK+++E L      K  E   L R+SP
Sbjct:   39 SVERVYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEDVG-MNQREISYVPGLYKIFDEILVNAADNKQRDKNMTAIKISIDPESNTISIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTADPKVKFFDGDDFTCVTFQPDLSKFKMEKLDKDIIALLTRRAYDVAGSCKGVKVTLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVNETVNERWEVCLTLSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKLI---EVVKKKNKAGVTVKPFQVKNHIWVFVNALIENPSFDSQTKENMTLQTKSFGSKCPLSDKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKATKNKQEMAFYSIPEFEEWKKHTENYKSWHIKYYKGLGTSTSKEAKEYFAEMEKHRITFRYSGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGSQARHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNLNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPVVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDVREIVNNIYRMLNHQDPLQMLPSYKNFKGVIHELGQNQYLVSGEVSVIDKNTIEVTELPVRTWTQAYKESVLEPMLQGSDKTPALINDYKEYHTDTTVKFLVRMSEEKLAQAE-SVGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQDILKEFFELRLHYYKLRKDWLVGSLGAEAAKLSNQARFVLEKIEGKVSIENKSKRELIRMLVQKGFESDPVAAWTKAQEKALEEDGGNESDTSLDSGSTSGPNFNYILNMPLWCLTKERVEELLKQRDLKRGELNELQRKSP 1168
[Close]
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A3Q0RLH9 (DNA topoisomerase 2 OS=Amphilophus citrinellus OX=61819 PE=3 SV=1)

HSP 1 Score: 1068.14 bits (2761), Expect = 0.000e+0
Identity = 534/1139 (46.88%), Postives = 761/1139 (66.81%), Query Frame = 1 
Query:  169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+ +  + ++EI YVP L+KIFDEILVNA+DNK+RD  M+ IKI ++ + N ISI N+G GIPVV H  E MY+P LIFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNMT+ +EP I+   G DFT +TF+PDL +FKM+NLD DI+AL  RRA+D+A + K V +  N  ++P+  F+ YV+LY  D  D      + +H  +N+  EV +T+S    F QISFVN I T  GG H++  V+++V  L++  +   K     ++P Q+KN +W+FVN+++ NP F+SQ+KE +T     F S+ LLSDKFV    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   +  W K T +Y  W IKYYKGLGTSTS EAKEYF ++++HR +F Y+G+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++  +   +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +LN + P+ M+P Y+NFKG I+E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TD  V+F++ +   KL   E    L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL   + RKD  +  + AEA K  NQ RF+  K  GK+ + N ++ E   +L Q  F+SDP+  W +A +K      +D  +     +S      +F Y+LNMP+   TK+K++ L      K  E   L R+SP
Sbjct:   48 VERVYQKKTQLEHILLRPDTYIGSVEPITQQMWVFDE-EIGMNQREITYVPGLYKIFDEILVNAADNKQRDKNMTAIKITIDPESNIISIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTSEPKIKFFDGDDFTCVTFQPDLAKFKMENLDKDIVALLTRRAYDVAGSCKGVKVSLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVHEAVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKLIEVVKKKNKAGVS-VKPFQVKNHIWVFVNALIENPSFDSQTKENMTLQTKSFGSKCLLSDKFVRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKATKNKQELSFYSIPEFDEWKKHTENYKSWHIKYYKGLGTSTSKEAKEYFADMEKHRITFRYTGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTHARHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNIYRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVVDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALISDYKEYHTDATVKFVVRMSEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEASKLSNQARFVLEKIEGKIVIENKSKRELVRMLVQKGFESDPVAAWAKAQEKSQEEVSQDGNESDSSLDSGSTSGPNFNYILNMPLWCLTKEKVDELLKQRDQKRGELNDLQRKSP 1178
[Close]
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A2I4CPW4 (DNA topoisomerase 2-beta OS=Austrofundulus limnaeus OX=52670 GN=top2b PE=4 SV=1)

HSP 1 Score: 1067.76 bits (2760), Expect = 0.000e+0
Identity = 534/1144 (46.68%), Postives = 761/1144 (66.52%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504
            ++E+ YQKKT +EHIL RPDSY+GS+    +  W+FD+    + ++EI YVP L+KIFDEILVNA+DNK+RD  MS IK+ ++ + N I+I N+G GIPVV H  E MY+P LIFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNMT+ T+  ++   G DFT +TF+PDL++FKM+ LD D++AL  RR +D+A + K V +  N  ++P+  F+ YV+LY  D  D      + +H T+N   EV +T+S    F QISFVN I T  GG HV+  V+++V  L++  +   K     ++P Q+KN +W+FVNS++ NP F+SQ+KE +T     F S+ +LSDKFV    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F EQFITP++KA K+ Q + FYS   ++ W K T ++  W IKYYKGLGTSTS EAKEYF ++++HR +F Y+G+EDD  + + F +++   RKEW+  +++ R+      + E+ ++      +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  LLN + P+ M+P Y+NFKG I+E    +Y  +G+  +L+  T+E+ +LP+   TQ YKE ++  ML+    + +++ DY++ +TDT V+F++ +   KL   E  + L ++  L S ++  +MVLFD    +KRY +  EIL EFF  RL  Y+ RKD  +  + +EA K  NQ RF+  K  GK+ + N ++ E   +L Q  F+SDP+  W +A +K     +ED       + S D        F Y+LNMP+   TK+K+++L      K  E   L R+SP 
Sbjct:   34 SVERVYQKKTQLEHILLRPDSYIGSVEPLTQQMWVFDEDVG-MNQREITYVPGLYKIFDEILVNAADNKQRDKTMSAIKVTIDPESNTITIWNNGKGIPVVEHKVEKMYVPALIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTTDSKVKFFDGDDFTCVTFQPDLSKFKMEKLDKDVVALLTRRVYDVAGSCKGVKVSLNGKKLPVHGFRSYVDLYVKDKLDETGVPLKVVHETVNERWEVCLTMSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVTKLIEVVKKKNKAGVS-VKPFQVKNHIWVFVNSLIENPSFDSQTKENMTLQMKSFGSKCVLSDKFVRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEQFITPLVKATKNKQELSFYSLPEFEEWKKQTENFKTWHIKYYKGLGTSTSKEAKEYFADMERHRITFKYNGAEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTQAKHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRLLNHQDPLPMLPNYKNFKGVIHELGHNQYLVSGEVSVLDKNTVEITDLPVRTWTQAYKESVLEPMLLGTDKTPALINDYKEYHTDTTVKFVVRMSEEKLAQAEA-VGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQEILKEFFDLRLHYYKLRKDWLLGSLGSEAAKLSNQARFVLEKIEGKITIENKSKRELIRMLVQKGFESDPVAAWSKAQEKTQ---EEDYPDGNESDSSVDSGSTSGPNFNYILNMPLWCLTKEKVDDLLKQRDQKRCELNDLQRKSPE 1166
[Close]
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A3Q0RFV2 (DNA topoisomerase 2 OS=Amphilophus citrinellus OX=61819 PE=3 SV=1)

HSP 1 Score: 1067.37 bits (2759), Expect = 0.000e+0
Identity = 534/1139 (46.88%), Postives = 761/1139 (66.81%), Query Frame = 1 
Query:  169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+ +  + ++EI YVP L+KIFDEILVNA+DNK+RD  M+ IKI ++ + N ISI N+G GIPVV H  E MY+P LIFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNMT+ +EP I+   G DFT +TF+PDL +FKM+NLD DI+AL  RRA+D+A + K V +  N  ++P+  F+ YV+LY  D  D      + +H  +N+  EV +T+S    F QISFVN I T  GG H++  V+++V  L++  +   K     ++P Q+KN +W+FVN+++ NP F+SQ+KE +T     F S+ LLSDKFV    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q + FYS   +  W K T +Y  W IKYYKGLGTSTS EAKEYF ++++HR +F Y+G+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++  +   +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +LN + P+ M+P Y+NFKG I+E  Q +Y  +G+  +++  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TD  V+F++ +   KL   E    L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL   + RKD  +  + AEA K  NQ RF+  K  GK+ + N ++ E   +L Q  F+SDP+  W +A +K      +D  +     +S      +F Y+LNMP+   TK+K++ L      K  E   L R+SP
Sbjct:   48 VERVYQKKTQLEHILLRPDTYIGSVEPITQQMWVFDE-EIGMNQREITYVPGLYKIFDEILVNAADNKQRDKNMTAIKITIDPESNIISIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTSEPKIKFFDGDDFTCVTFQPDLAKFKMENLDKDIVALLTRRAYDVAGSCKGVKVSLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVHEAVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKLIEVVKKKNKAGVS-VKPFQVKNHIWVFVNALIENPSFDSQTKENMTLQTKSFGSKCLLSDKFVRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKATKNKQELSFYSIPEFDEWKKHTENYKSWHIKYYKGLGTSTSKEAKEYFADMEKHRITFRYTGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTHARHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNIYRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVVDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALISDYKEYHTDATVKFVVRMSEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEASKLSNQARFVLEKIEGKIVIENKSKRELVRMLVQKGFESDPVAAWAKAQEKSQEEVSQDGNESDSSLDSGSTSGPNFNYILNMPLWCLTKEKVDELLKQRDQKRGELNDLQRKSP 1178
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Match: top2b (DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GENE-041008-136])

HSP 1 Score: 1064.29 bits (2751), Expect = 0.000e+0
Identity = 533/1134 (47.00%), Postives = 764/1134 (67.37%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIW----EQALKKEHRIFDEDPVKKGIFEESY-DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEM 3483
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+     + +EI YVP L+KIFDEILVNA+DNK+RD  MS IKI ++ + N +SI N+G GIPVV H  E MY+P LIFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNMT+ ++P I+   G DFT +TF+PDL++FKM+ LD DI+AL  RRA+D+A + K V ++ N  ++P+  F+ YV+LY  D  D      + ++ ++N   EV +T+S    F QISFVN I T  GG H++  V+++V  L++  +   K     ++P Q+KN +W+FVN+++ NP F+SQ+KE +T     F S+  LS+KF+    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESLKSLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F E+FITPI+KA K+ Q IPFYS   +  W K T +Y  W IKYYKGLGTSTS EAKEYF ++++HR  F Y G+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++      +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TC+KRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +L+ + P+ M+P Y+NFKG I+E  Q +Y  +G+  +L+  T+E+ ELPI   TQ YKE ++  ML  ++   +++ DY++ +TDT V+F++ +   KL   E    L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL  Y+ RKD  V  + AE+ K  NQ RF+  K  GK+++ N ++ E   +L Q  ++SDP+  W    E+AL++E R  +E          S  +F Y+LNMP+   TK+K++ L  L +  L +AE+
Sbjct:   49 SVERVYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNL-REITYVPGLYKIFDEILVNAADNKQRDKNMSSIKITIDPESNTVSIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWQNNMTKTSDPKIKYFDGDDFTCVTFQPDLSKFKMEKLDKDIVALLTRRAYDVAGSCKGVKVFLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVNESVNERWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVSKLIEVVKKKNKAGVT-VKPFQVKNHIWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEIPFYSIPEFDEWKKQTENYKTWHIKYYKGLGTSTSKEAKEYFADMERHRIMFKYGGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTATRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCMKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLDHQDPLPMLPSYKNFKGVIHELGQNQYVVSGEISVLDKNTIEITELPIRTWTQAYKESVLEPMLQGTEKTPALINDYKEYHTDTTVKFVVRMTEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQDILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQRGYESDPVAAWNRAQEKALEEEDRDGNESDSSIDSGSSSGPNFNYILNMPLWCLTKEKVDEL--LKQRDLKKAEL 1172
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453])

HSP 1 Score: 987.252 bits (2551), Expect = 0.000e+0
Identity = 501/1133 (44.22%), Postives = 726/1133 (64.08%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDSQ-----FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKED--AKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRI-FDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+    +  ++I +VP L+KIFDEILVNA+DNK+RD+ M+ IKIN++ + N IS+ N+G GIPVV H  E +++P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+   + Y +KQTW +NM++  E  I+   G D+T ITF+PDLT+FKM +LD D +AL  RRA+DIA   K V +  N T++ +  F+ YV+LY  D  D        +H  +N+  EV +TLS    F Q+SFVN I T  GG H +   +++V  L+   E + K +     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T     F S  LLS+KF+     CG+++ I + +  K     +   S  K   I  + KLDDA  AG K S  CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ Y+K Y   +SLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+K     Q   FYS   +  W +   +   W+IKYYKGLGTSTS EAKEYF ++ +HR  F YSG  DD  + + F R++  +RK+W+  ++  R+   + N+ EE ++ K  +S++Y DF+NKEL+++SN DN R+IP ++DGLKP QRK+++ C KRN  ++VKV QL+GSV+E++ YHH E S+  T++ L              P+G FGTR++GGKD+AS RYI T LS + R +FP+ DDN L+  YDDN  +EP WY PIIP VL+NG +G+GTGW   +PN++  +II N+  +LN   P+ M+P Y+ FKG+I E     Y  +G+  I++S T+E+ ELP+   TQ YKE ++  ML  S    +++ DY + +TD+ VRF++ +  +  ++     L ++  L S ++ T+MVLFD    +K+Y    +IL +FF+ RL  Y  RK   V  + AE+ K  NQ RFI  K  G L + N  + E   +L++  +DSDP+K+W+QA +KE  I   E+  +K       D+ YLL+MP+   TK+K + L     +KL E  ML +++P
Sbjct:   28 SVERIYQKKTQLEHILLRPDTYIGSVEPLSQQMWVFDEDVG-LNCRDITFVPGLYKIFDEILVNAADNKQRDNSMNCIKINIDSENNTISVWNNGKGIPVVEHKVEKVFVPALIFGQLLTSSNYDDDQKKVTGGRNGYGAKLCNIFSTKFTVETACAESKYSFKQTWFDNMSRAGEAKIKPFSGDDYTCITFRPDLTKFKMQSLDRDTVALMTRRAYDIAGASKGVRVLLNGTKLSVNGFRSYVDLYLKDKVDETGTPLTVVHEVVNSRWEVCLTLSEK-GFQQVSFVNSIATTKGGRHTDYVADQIVSKLI---EVVKKRNKGGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKSFGSTCLLSEKFIKQANTCGIVDSIMNWVKFKAQNQLNKKCSAVKHTKIKGVPKLDDANDAGGKHSAGCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKIMGLQYRKNYSDPDSLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSSKNQEFSFYSIPEFTEWKEKQNNIKSWKIKYYKGLGTSTSKEAKEYFSDMARHRIPFRYSGPADDEAITLAFSRKKIEERKDWLTSFMINRRQRREHNLPEEYLYGKETSSLTYHDFVNKELVLFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEISLMMTIVGL--------------PLGQFGTRLHGGKDSASPRYIFTMLSSLSRLLFPSVDDNLLKYNYDDNVKVEPEWYIPIIPLVLVNGGDGIGTGWACKLPNFDVREIINNIHRMLNGDEPLPMLPSYKGFKGTIEELTSNHYLISGEVSIIDSTTIEISELPVKTWTQSYKENVLEVMLNGSDKVPALITDYREYHTDSTVRFVVKMTEERLIEAEAAGLHKVFKLQSPLTCTSMVLFDHVGSLKKYEFVQDILKDFFELRLKYYVLRKAWLVGMLGAESAKLSNQARFILEKIEGTLVIENKPKKELIRMLQEMGYDSDPVKVWKQAQEKEVEIDAGEEDEQKEEQTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKLTELNMLEKKTP 1141
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453])

HSP 1 Score: 986.867 bits (2550), Expect = 0.000e+0
Identity = 501/1133 (44.22%), Postives = 726/1133 (64.08%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDSQ-----FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKED--AKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRI-FDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++E+ YQKKT +EHIL RPD+Y+GS+    +  W+FD+    +  ++I +VP L+KIFDEILVNA+DNK+RD+ M+ IKIN++ + N IS+ N+G GIPVV H  E +++P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+   + Y +KQTW +NM++  E  I+   G D+T ITF+PDLT+FKM +LD D +AL  RRA+DIA   K V +  N T++ +  F+ YV+LY  D  D        +H  +N+  EV +TLS    F Q+SFVN I T  GG H +   +++V  L+   E + K +     ++P Q+KN +W+FVN ++ NP F+SQ+KE +T     F S  LLS+KF+     CG+++ I + +  K     +   S  K   I  + KLDDA  AG K S  CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ Y+K Y   +SLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+K     Q   FYS   +  W +   +   W+IKYYKGLGTSTS EAKEYF ++ +HR  F YSG  DD  + + F R++  +RK+W+  ++  R+   + N+ EE ++ K  +S++Y DF+NKEL+++SN DN R+IP ++DGLKP QRK+++ C KRN  ++VKV QL+GSV+E++ YHH E S+  T++ L              P+G FGTR++GGKD+AS RYI T LS + R +FP+ DDN L+  YDDN  +EP WY PIIP VL+NG +G+GTGW   +PN++  +II N+  +LN   P+ M+P Y+ FKG+I E     Y  +G+  I++S T+E+ ELP+   TQ YKE ++  ML  S    +++ DY + +TD+ VRF++ +  +  ++     L ++  L S ++ T+MVLFD    +K+Y    +IL +FF+ RL  Y  RK   V  + AE+ K  NQ RFI  K  G L + N  + E   +L++  +DSDP+K+W+QA +KE  I   E+  +K       D+ YLL+MP+   TK+K + L     +KL E  ML +++P
Sbjct:   28 SVERIYQKKTQLEHILLRPDTYIGSVEPLSQQMWVFDEDVG-LNCRDITFVPGLYKIFDEILVNAADNKQRDNSMNCIKINIDSENNTISVWNNGKGIPVVEHKVEKVFVPALIFGQLLTSSNYDDDQKKVTGGRNGYGAKLCNIFSTKFTVETACAESKYSFKQTWFDNMSRAGEAKIKPFSGDDYTCITFRPDLTKFKMQSLDRDTVALMTRRAYDIAGASKGVRVLLNGTKLSVNGFRSYVDLYLKDKVDETGTPLTVVHEVVNSRWEVCLTLSEK-GFQQVSFVNSIATTKGGRHTDYVADQIVSKLI---EVVKKRNKGGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKSFGSTCLLSEKFIKQANTCGIVDSIMNWVKFKAQNQLNKKCSAVKHTKIKGVPKLDDANDAGGKHSAGCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKIMGLQYRKNYSDPDSLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSSKNQEFSFYSIPEFTEWKEKQNNIKSWKIKYYKGLGTSTSKEAKEYFSDMARHRIPFRYSGPADDEAITLAFSRKKIEERKDWLTSFMINRRQRREHNLPEEYLYGKETSSLTYHDFVNKELVLFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEISLMMTIVGL--------------PLGQFGTRLHGGKDSASPRYIFTMLSSLSRLLFPSVDDNLLKYNYDDNVKVEPEWYIPIIPLVLVNGGDGIGTGWACKLPNFDVREIINNIHRMLNGDEPLPMLPSYKGFKGTIEELTSNHYLISGEVSIIDSTTIEISELPVKTWTQSYKENVLEVMLNGSDKVPALITDYREYHTDSTVRFVVKMTEERLIEAEAAGLHKVFKLQSPLTCTSMVLFDHVGSLKKYEFVQDILKDFFELRLKYYVLRKAWLVGMLGAESAKLSNQARFILEKIEGTLVIENKPKKELIRMLQEMGYDSDPVKVWKQAQEKEVEIDAGEEDEQKEEQTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKLTELNMLEKKTP 1141
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Sea Lamprey
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453])

HSP 1 Score: 730.709 bits (1885), Expect = 0.000e+0
Identity = 373/821 (45.43%), Postives = 533/821 (64.92%), Query Frame = 1 
Query: 1135 IKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYK---GLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDE---------DPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            +KN +WIFVN +V NP F+SQ+KE +T    KF S   LS+KF+   + CG++E I        QS +N       S +K++ +  I KLDDA  AG K S +CTLILTEGDSAK+ A+SGL V+G+D++G+F L+GK LN R    ++++ N +  +++  +G+ YKKKY   ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LLQ  F E+FITPI+K  K+ Q +PFYS   +  W   T +Y  W+IKYYK   GLGTSTS EAKEYF ++ +HR  F YSG EDD  + + F R++   RKEW+  W+  R+   ++ + E  ++ K    ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN  ++VKV QL+GSV+E++ YHH E+S+  T++ LAQ++VGSNNIN+L P+G FGTR+ GGKD AS RYI T +S + R +FP  DDN L+  +DDNQ +EP WY PIIP VL+NGA+G+GTGW + IPN+NP +II N+R LL+ + P+ M+PWY+NFKGSI+E    ++  +G+  IL+S+T+E+ ELP+   TQ YKE ++  ML     +  ++ DY++ +TDT VRFII +  +  L+     L ++  L + ++  +MVLFD    +K+Y +  +IL EF++ RL  Y  RK+     + AE+ K  NQ RFI  K  G + + N  + E   +L+   +DSDPI+ W++A  K +  F+E         D  + G    S      D+ Y+LNM +   TK++ + L      K+ E E L  +SP
Sbjct:    1 VKNHMWIFVNCLVENPTFDSQTKENMTLQHKKFGSTCSLSEKFIKTAMGCGIVESILNWVKFKAQSQLNQNC----SAKKISKLRGIPKLDDANDAGGKNSQKCTLILTEGDSAKTLAVSGLGVVGRDHYGIFPLRGKMLNVREASYKQIMENAEINNLIKIVGLQYKKKYDDPESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLQHRFLEEFITPIVKVSKNKQELPFYSMPEFDEWKNETSNYKTWKIKYYKDMPGLGTSTSKEAKEYFADMKRHRIEFRYSGPEDDNAITLAFSRKKIEDRKEWLTNWMVDRRQRREQGLPESFLYGKQTAYLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQSLMMTIVSLAQNFVGSNNINVLQPIGQFGTRLNGGKDAASPRYIFTMISTVARLLFPPVDDNLLKFLWDDNQRVEPEWYCPIIPLVLVNGADGIGTGWASRIPNFNPREIINNIRRLLDGEEPLPMLPWYKNFKGSIDELGPNQFMFSGEISILDSETIEISELPVRTWTQTYKESVLEPMLSGTDKTTPLITDYKEYHTDTTVRFIIKISREKLLEAEAAGLHKVFKLQAPLTCNSMVLFDHLGCLKKYESVADILREFYEVRLKYYSLRKEWLNGILGAESAKLSNQARFILEKIEGTVVIENKPKKELIRMLEARGYDSDPIRAWKEAQVKSN--FEEEANSQEDSDDGEESGSATSSTPSSGPDYNYILNMALWCLTKERKDELLRQRDLKIQELEDLKCKSP 815
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007762.1 (pep scaffold:Pmarinus_7.0:GL492656:1017:4077:-1 gene:ENSPMAG00000007010.1 transcript:ENSPMAT00000007762.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 318.161 bits (814), Expect = 5.683e-99
Identity = 156/326 (47.85%), Postives = 221/326 (67.79%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYI 1122
            ++E+ YQKKT +EHIL RPD+Y+GS+    ++ W+FD+    +  +++ YVP LFKIFDEILVNA+DNK+RD  M+ IK+ ++ + N+IS+ N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VETS   +   +KQ W NNM++  + VI+ + G DFT ITF+PDLT+F M  LD DI+A+  RRA+DIA   K V ++ N  ++P+T F++YV+ Y  D  D        +H  ++N  EV +T+S    F Q+SFVN I T  GG HV+  V+++   L+   ET+ K++   I
Sbjct:   27 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQNMWVFDEGIG-MNCRDVTYVPGLFKIFDEILVNAADNKQRDPNMTCIKVTIDPENNKISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTQFTVETSCSESKKMFKQKWMNNMSKECDSVIKPSSGEDFTCITFQPDLTKFNMTILDKDIMAIMTRRAYDIAGICKGVKVFLNGQKLPLTGFRKYVDFYLKDRVDESGMPLHVVHEVVSNRWEVCLTISEK-GFQQVSFVNSIATTKGGRHVDYVVDQVTSKLI---ETVKKKNKAGI 347
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Yeast
Match: TOP2 (Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant [Source:SGD;Acc:S000005032])

HSP 1 Score: 840.491 bits (2170), Expect = 0.000e+0
Identity = 478/1164 (41.07%), Postives = 695/1164 (59.71%), Query Frame = 1 
Query:  181 YQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEK-AQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY----------DNNDS--------QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNN-----ILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKA--FKDTQ-CIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFH-YSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK--SIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIK-------------------DAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIF---EESYD-FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504
            YQK + +EHIL RPD+Y+GS+    + QWI+D+  + +IEK +  VP LFKIFDEILVNA+DNK RD  M  I +N++ +E+ I + NDG GIP+ +H+ EN+YIP +IFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F +ET+    G +Y Q W NNM+    P I    +GP +T +TFKPDLTRF M  LD DI+ +  RR +DI  +++++++Y N   + I +FK YVELY          DN +           ++  INN  EVA  +S   SF QISFVN I T  GG HVN   +++V+ + +  +   K+  K     QIKN+++IF+N ++ NP F SQ+KE LT+    F S+  +  +++N I+   L  R+  + +  ++   +L+K +      I +  KL+DA  AGTK   +CTL+LTEGDSA S A++GL V+G+DY+G + L+GK LN R     ++L N + + +   +G+ ++KKY   E  KSLRYG +MIM DQD DGSHIKGLI+NF   ++P LL +  F  +FITPI+K    K T+  I FY+   Y+ W +       W+ KYYKGLGTS + E +EYF N+D+H K FH   G++ DY+  + F ++++  RKEW+ Q+  +   +L   + E          I   DFINKELI++S  DN+R+IP+++DG KP QRK++Y C K+N   ++KV QL+  VSE T YHH E+S+  T+I LAQ++VGSNNI LL+P G FGTR  GGKD A+ARYI T+L+ + R IF  ADD   +   +D +T+EP WY PI+P +L+NGA G+GTGW T+IP +NP +II+N+R L+ND+   QM PW+R + G+I E +  +Y+  G+   +    LE+ ELP    T   KEY++  +  N K    ++D E+++ D  ++FII L  +   K  ++   +   L S IS  NMV FD H +IK+Y++  EIL EF+  RL  Y+KRKDH  +++  E +K   Q++FIK                   +   L    FN+         N   ++ I   + A   E          + +    EE Y  + YLL M + S TK++ + L    + K  E E L + S +
Sbjct:   12 YQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLKSLEKKRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVS-DISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKKKKKKSVKSF---QIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEE--NALKKSDGTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKKY---EDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYI-DLAFSKKKADDRKEWLRQY--EPGTVLDPTLKE----------IPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDN-IKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAK 1152
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO44813 (DNA topoisomerase 2 [Source:UniProtKB/TrEMBL;Acc:A7RUU5])

HSP 1 Score: 434.876 bits (1117), Expect = 5.994e-140
Identity = 225/486 (46.30%), Postives = 319/486 (65.64%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEK-AQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQ-------------FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKM 1560
            ++E+ Y KKT +EHIL RPD+Y+GS+  + ++ +++D     I+ +EI YVP LFKIFDEILVNA+DNK+RD  MS IKI +N ++N IS+ NDG GIP+ +H    +Y+PT+IFG LLTSSNY+D  +K TGGRNG+GAKLCN+FSK FSVET+      R+KQ WTNNM +  EPVI++     ++T ITF+PDL +FKM+ LD D +AL  RRA+DIA++++ VS+  N  ++ + +FK YV+L     ++              +H  +NN  EV VT+S    F Q SFVN I T  GG HVN   +++V  L+    T++K+  K    I+P QIK+ LW+F+N ++ NP F+SQ+KE +T     F S+  LSDKF+  + + G++E + + M  K+    +   S  K + I  I KLDDA  AG K S  CTLILTEGDSAK+ A+SGL ++G+D +GVF L+GK LN R    +++
Sbjct:   36 SVERIYTKKTQLEHILLRPDTYIGSVEPNKQNMFVYDDILEAIVNREITYVPGLFKIFDEILVNAADNKQRDPAMSTIKIEINPEKNFISVWNDGRGIPIEMHKEHQVYVPTMIFGQLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSKKFSVETACLENKKRFKQVWTNNMGKAAEPVIKEFTSNKEYTCITFQPDLEKFKMETLDRDTVALLTRRAYDIAASVRGVSVILNGKKLKVKTFKDYVQLCLKGATKDKEEDDEEEKKPTVVHEVVNNRWEVCVTVSDK-GFQQASFVNSIATTKGGTHVNYVTDQIVDKLM----TVIKKKNKGGLAIKPFQIKSHLWVFINCLIENPAFDSQTKENMTLRAKDFGSKCELSDKFIKAVQNSGVMENVMNWMRFKEKAQLNKKCSGSKHSKIRGIPKLDDANDAGGKNSRHCTLILTEGDSAKTLAISGLSIVGRDRYGVFPLRGKLLNVREASHKQV 516
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO44811 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUU3])

HSP 1 Score: 232.261 bits (591), Expect = 2.406e-67
Identity = 132/353 (37.39%), Postives = 204/353 (57.79%), Query Frame = 1 
Query: 2485 LSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSI---VRDYEDRNTDTEVRFIIHLKLD-LKEI-RLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY------DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504
            LS + + +FP +D+  L+   +DNQ IEP WY PIIP +L+NGA G+GTG+ T +PNY+P  I EN+R ++N + P +M+PWY+NF G+I + D  KY  TG   +++  TLE+ ELPIG  TQ YKE ++  ML  +  +   + DY++ +T+T VRF+I +  + ++E  ++ L +   L + I+T+NMVLFD    +K+Y T  EIL EFF  R+  Y  RK +    + AE+ K  +Q RFI  K  G + + N  + +   +L Q  + SDP+K W+ +      + D D         +       DF YLLNM + S +++K + L      K  E E L ++SP+
Sbjct:    2 LSTVSKMLFPPSDEPNLKFLNEDNQRIEPEWYCPIIPTILVNGAEGIGTGYSTKVPNYDPRAIAENIRKMMNGEEPEEMLPWYKNFIGTITKVDDTKYSVTGNIEVIDDTTLEITELPIGTWTQSYKESVLEPMLHGTDKVPPCITDYKEYHTETRVRFVITMAENKMREAEQVGLHKKFKLEATINTSNMVLFDAMGCLKKYDTTREILKEFFTLRMERYIMRKAYMEGMLTAESGKLNSQARFILEKIEGTIVIENKPKRDLITMLVQRGYPSDPVKAWKDSQDTTLGVDDSDDDTMSTVSSTASGAGGPDFNYLLNMSMWSLSQEKKDELLKQRDQKAAELEDLRKKSPK 354
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO29547 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T3B9])

HSP 1 Score: 177.948 bits (450), Expect = 2.746e-51
Identity = 78/166 (46.99%), Postives = 121/166 (72.89%), Query Frame = 1 
Query: 1843 QNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSE 2340
            + W   T ++  W++KYYKGLGTST  EAKEYF ++++H+ +F Y G  DD  + M F +++  +RK+W+ + L++RK   ++ + E  ++ K+   +SY DF+NKELI++SN DN R+IPS++DGLKP QRK+++TC KRN  ++VKV QL+GS++EL+ YHH E
Sbjct:    2 EEWKAGTANHKSWKVKYYKGLGTSTPKEAKEYFSDMERHKINFKYEGPHDDEAIVMAFSKKKIQERKDWLTRGLEERKWRREQGLSELYLYEKDTKRVSYCDFVNKELILFSNTDNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLAGSIAELSAYHHGE 167
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO44812 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUU4])

HSP 1 Score: 127.102 bits (318), Expect = 2.375e-34
Identity = 58/114 (50.88%), Postives = 77/114 (67.54%), Query Frame = 1 
Query: 1561 LMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKG 1902
            L N +  +++   G+ Y KKY +++ LKSLRYG +MIM DQD DGSHIKGL++NF H NWP LL+L F EQFITPI+K  K  +   FYS   Y+ W     ++  W++KYYKG
Sbjct:    1 LDNAEINNIIKITGLQYNKKYKSEDDLKSLRYGHLMIMTDQDQDGSHIKGLVINFIHSNWPGLLKLGFVEQFITPIVKVSKGKEEHSFYSIPEYEEWKAGNANHKSWKVKYYKG 114
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO25698 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DVR1])

HSP 1 Score: 76.2554 bits (186), Expect = 5.147e-15
Identity = 54/166 (32.53%), Postives = 83/166 (50.00%), Query Frame = 1 
Query: 1414 GECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKE-SLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLG 1908
             +C + L EGDSA   A  G D   +++  +  L+GK LN     + K+  N++ K++  +LG+S   +   +  +L  +RY KV+IM D D DGSHI  LIL FF     E+++  +     TP +   K  Q    Y+ +  Q  + A        I+ YKGLG
Sbjct:   61 AQCEIFLVEGDSAGGTAKQGRD---RNFQAILPLRGKILNVEKAMQHKVFENEEIKNMFTALGVSIGTEEDPRALNLSKVRYHKVVIMCDADVDGSHIATLILTFFFRYMREMIEQGYV-YIATPPLYLVKKGQKRE-YAWDDNQRDLIAQKMGGGVTIQRYKGLG 221
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2b (DNA topoisomerase II beta [Source:NCBI gene;Acc:101157229])

HSP 1 Score: 1055.05 bits (2727), Expect = 0.000e+0
Identity = 523/1123 (46.57%), Postives = 754/1123 (67.14%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDS--QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENL 3444
            ++E+ YQKKT +EHIL RPD+YVGS+    +  W+FD+    + ++EI YVP L+KIFDEILVNA+DNK+RD  MS IKI ++ + N I+I N+G GIPVV H  E MY+P LIFG+LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ +   + +KQTW NNMT+ +EP I    G DFT +TF+PDL +FKM+ LD D +AL  RRA+D+A + + V +  N  ++P+  F+ YV+LY     D      + ++  +N+  EV +T+S    F QISFVN I T  GG H++  V+++V  ++   E + K++     ++P Q+KN +W+FVN+++ NP F+SQ+KE +T     F S+ +LS+KF+    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F EQFITPI+KA K+ Q + FYS   ++ W K T +Y  W +KYYKGLGTSTS EAKEYF ++++HR +F Y G+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++      +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNNIN+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +LN + P+ M+P Y+NFKG I+E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TD+ V+F++ +   KL   E  + L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL   + RKD  +  + AEA K  NQ RF+  K  GK+++ N ++ E   +L Q  ++SDP+  W +A +K     + D  +     +S      +F Y+LNMP+   TK+K+E L
Sbjct:   39 SVERVYQKKTPLEHILLRPDTYVGSVEPVSQPMWVFDEDVG-MNQREITYVPGLYKIFDEILVNAADNKQRDKNMSAIKITIDPESNTITIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTSEPKIRFFDGDDFTCVTFQPDLAKFKMEKLDRDTVALMTRRAYDVAGSCRGVKVTLNGKKLPVNGFRSYVDLYVKEKLDETGVPLKVVNEMVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKII---EVVKKKNKAGVTVKPFQVKNHIWVFVNALIENPTFDSQTKENMTLQTKSFGSKCVLSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEQFITPIVKATKNKQELSFYSLPEFEEWKKQTDNYKSWHVKYYKGLGTSTSKEAKEYFADMERHRITFRYQGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEKYLYGTQTKHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINILQPLGQFGTRINGGKDAASPRYIFTMLSPLTKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVLDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALINDYKEYHTDSTVKFVVRMSEEKLAQAEA-VGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEAAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQKGYESDPVAAWSKAQEKAQEEGETDGNQSDSSVDSGSSSGPNFNYILNMPLWCLTKEKVEEL 1151
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2a (DNA topoisomerase II alpha [Source:NCBI gene;Acc:101158729])

HSP 1 Score: 1018.84 bits (2633), Expect = 0.000e+0
Identity = 516/1161 (44.44%), Postives = 751/1161 (64.69%), Query Frame = 1 
Query:  112 IRCKYSNLP--TTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIF-----EESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            ++  Y N P   T K     ++E+ YQKKT +EHIL RPDSY+GS+    +  W++D     +  +++ +VP L+KIFDEILVNA+DNK+RD  MS IK+N++ + N IS+ N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ + +   +KQTW +NM +  +  I+   G +FT ITFKPDL++FKM  LD D +AL  RRA+D+A + K V ++FN  ++PIT F+ YV++Y  D  D        IH  +N   EV +T+S    F Q+SFVN I T  GG H++   +++V  L+   E + K++     ++P Q+KN +W+FVN +V NP F+SQ+KE +T     F S   LSDKF      CG++E I        Q+ +N K     S  K   I  + KLDDA  AG K S  CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +V+  LG+ YKK Y   ESLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+KA      + FYS   +  W +   ++  W+IKYYKGLGTSTS EAKEYF ++++HR  F YSG EDD  + + F +++  +RKEW+  ++  R+   + N+ E+ ++ ++  S+SY DFINKEL+++SN DN R+IP ++DG KP QRK+++ C KRN  ++VKV QL+GSV+E++ YHH E S+  T++ LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP  DDN L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW + IPNY+  +I+ N+  +L+ + P+ M+P Y+ F+G+I++    +Y  +G+  I++S T+E+ ELP+   TQ YKE ++  ML  +    +++ DY++ +TD  VRF++ +  +  ++     L ++  L S ++  +MVLFD    +K+Y +  +IL +FF  R+  Y  RK+  V  + AE+ K  NQ RFI  K  G L + N  + E   +L++  +DSDP++ W++A KK+    + +  ++            D+ YLL+MP+   TK+K E+L     +K+ E   L  +SP
Sbjct:    5 LKALYENKPLEKTKKDSKRLSVERIYQKKTQLEHILLRPDSYIGSVEPVTQQMWVYDVDVG-LNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVNIDVENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDEQKKVTGGRNGYGAKLCNIFSTKFTVETACKESRKTFKQTWYDNMGRAGDTNIKAFDGEEFTCITFKPDLSKFKMSTLDKDTVALMTRRAYDVAGSSKGVKVFFNGKRLPITGFRSYVDMYVKDKVDELGGPLTVIHEAVNERWEVCLTMSEK-GFQQVSFVNSIATTKGGRHIDYVADQIVGRLI---EVVKKKNKAGVAVKPFQVKNHMWLFVNCLVENPTFDSQTKENMTLQQKSFGSTCSLSDKFFKQATSCGIVESIMNWVKFKAQTQLNKKC----SAVKHTKIKGVPKLDDANDAGGKNSIGCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNVIKILGLQYKKNYSDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKNQLSFYSIPEFNAWKETQSNHKSWKIKYYKGLGTSTSQEAKEYFSDMERHRIPFKYSGPEDDEAISLAFSKKKVEERKEWLTNFMVNRRQRREHNLPEDYLYGQSTKSLSYNDFINKELVLFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSPLARLVFPPVDDNLLKYNYDDNQRVEPEWYIPIIPTVLVNGAEGIGTGWASKIPNYDIREIVSNIHRMLDGEEPLPMLPNYKGFRGTIDQVMSNQYMNSGEVAIIDSTTIEISELPVKTWTQAYKENVLEPMLNGTDKVPALITDYKEYHTDATVRFVVKMTEEKLMEAEAAGLHKVFKLQSPLTCNSMVLFDYAGSLKKYESVQDILKDFFDLRMKYYVLRKEWLVGMLGAESSKLSNQARFILEKIQGTLVIENKPKKELIRMLQEMGYDSDPVRAWKEAQKKDEDDMEAEEEQEEGAEREDQSSGADYNYLLSMPMWFLTKEKKEDLCKQRDAKMTELNTLKGKSP 1156
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2b (DNA topoisomerase II beta [Source:NCBI gene;Acc:101157229])

HSP 1 Score: 858.981 bits (2218), Expect = 0.000e+0
Identity = 429/959 (44.73%), Postives = 631/959 (65.80%), Query Frame = 1 
Query:  658 QTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENL 3444
            QTW NNMT+ +EP I    G DFT +TF+PDL +FKM+ LD D +AL  RRA+D+A + + V +  N  ++P+  F+ YV+LY  +  D      + ++  +N+  EV +T+S    F QISFVN I T  GG H++  V+++V  ++   E + K++     ++P Q+KN +W+FVN+++ NP F+SQ+KE +T     F S+ +LS+KF+    +CG++E I        Q+ +N K     S  K + I  I KLDDA  AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R    ++++ N +  +++  +G+ YKK Y   ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+  F EQFITPI+KA K+ Q + FYS   ++ W K T +Y  W +KYYKGLGTSTS EAKEYF ++++HR +F Y G+EDD  + + F ++++  RKEW+  +++ R+      + E+ ++      +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN  ++VKV QL+GSV+E++ YHH E+++  T+++LAQ++VGSNNIN+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +LN + P+ M+P Y+NFKG I+E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TD+ V+F++ +   KL   E  + L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL   + RKD  +  + AEA K  NQ RF+  K  GK+++ N ++ E   +L Q  ++SDP+  W +A +K     + D  +     +S      +F Y+LNMP+   TK+K+E L
Sbjct:  123 QTWQNNMTKTSEPKIRFFDGDDFTCVTFQPDLAKFKMEKLDRDTVALMTRRAYDVAGSCRGVKVTLNGKKLPVNGFRSYVDLYVKEKLDETGVPLKVVNEMVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKII---EVVKKKNKAGVTVKPFQVKNHIWVFVNALIENPTFDSQTKENMTLQTKSFGSKCVLSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEQFITPIVKATKNKQELSFYSLPEFEEWKKQTDNYKSWHVKYYKGLGTSTSKEAKEYFADMERHRITFRYQGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEKYLYGTQTKHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINILQPLGQFGTRINGGKDAASPRYIFTMLSPLTKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVLDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALINDYKEYHTDSTVKFVVRMSEEKLAQAEA-VGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEAAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQKGYESDPVAAWSKAQEKAQEEGETDGNQSDSSVDSGSSSGPNFNYILNMPLWCLTKEKVEEL 1072
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2b (DNA topoisomerase II beta [Source:NCBI gene;Acc:101157229])

HSP 1 Score: 245.743 bits (626), Expect = 7.727e-72
Identity = 130/332 (39.16%), Postives = 202/332 (60.84%), Query Frame = 1 
Query: 2488 SPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENL 3444
            SP+ + +FPA D N L+  YDDNQ +EP WY PIIP VL+NGA G+GTGW   IPNY+P +I+ N+  +LN + P+ M+P Y+NFKG I+E  Q +Y  +G+  +L+  T+E+ ELP+   TQ YKE ++  ML     + +++ DY++ +TD+ V+F++ +   KL   E  + L ++  L S ++  +MVLFD    +KRY +  +IL EFF+ RL   + RKD  +  + AEA K  NQ RF+  K  GK+++ N ++ E   +L Q  ++SDP+  W +A +K     + D  +     +S      +F Y+LNMP+   TK+K+E L
Sbjct:    5 SPLTKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVLDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALINDYKEYHTDSTVKFVVRMSEEKLAQAE-AVGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEAAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQKGYESDPVAAWSKAQEKAQEEGETDGNQSDSSVDSGSSSGPNFNYILNMPLWCLTKEKVEEL 335
[Close]
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2a (DNA topoisomerase II alpha [Source:NCBI gene;Acc:101158729])

HSP 1 Score: 226.868 bits (577), Expect = 3.925e-67
Identity = 105/196 (53.57%), Postives = 143/196 (72.96%), Query Frame = 1 
Query:  166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDL 753
            ++E+ YQKKT +EHIL RPDSY+GS+    +  W++D     +  +++ +VP L+KIFDEILVNA+DNK+RD  MS IK+N++ + N IS+ N+G GIPVV H  E +Y+P LIFG LLTSSNYDD  +K TGGRNG+GAKLCN+FS  F+VET+ + +   +KQTW +NM +  +  I+   G +FT ITFKPDL
Sbjct:   19 SVERIYQKKTQLEHILLRPDSYIGSVEPVTQQMWVYDVDVG-LNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVNIDVENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDEQKKVTGGRNGYGAKLCNIFSTKFTVETACKESRKTFKQTWYDNMGRAGDTNIKAFDGEEFTCITFKPDL 213
[Close]
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000064303.1 (SMESG000064303.1)

HSP 1 Score: 2056.18 bits (5326), Expect = 0.000e+0
Identity = 1041/1089 (95.59%), Postives = 1047/1089 (96.14%), Query Frame = 1 
Query:  310 MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPRXXXXXXXXXXXXXXKNLYADTELQ 3576
            MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSI  K  I  E+   S  D+                         N +K+   T+LSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVL+NGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQ LKKEHRIFDEDPVKKGI EESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPREIWLEELQILEEKIKNLYADTELQ
Sbjct:    1 MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSIIIK--IMCEIFHRSWTDS-------------------------NHLKEKLFTRLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLVNGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQTLKKEHRIFDEDPVKKGILEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPREIWLEELQILEEKIKNLYADTELQ 1062
[Close]
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037565.1 (SMESG000037565.1)

HSP 1 Score: 1004.59 bits (2596), Expect = 0.000e+0
Identity = 521/1138 (45.78%), Postives = 736/1138 (64.67%), Query Frame = 1 
Query:  163 ENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDSQF--IHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPN--QIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY--DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504
            E+IEK Y KKT +EHIL RPDSYVGSI    K+ WIFD  +N ++EK I Y P L+KI+DEILVNASDNK RD +MS I+I++N  +N I I N+G GIPVV+H   N+++PT+IFG LLTS+N++D  ++ TGGRNG+GAKLCN+FS  F +ETS++  G  +KQTWT NM   ++P+I   Q  DFT +TF PDL RF M +LD + IALF RRA+DIA+    + +Y N  QIP+ +FK YVELY     D+N+ +   I+    +  EVA+T S + +F Q+SFVN I T  GG HVN   ++    L++  +  +K D + ++    Q+K ++W+FV  ++ NP F+SQ+KE +T     F S   L+DKF++ +  CG++E+I +M  M K     D   S  K   + DI KLDDA  AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R    +++  N +  +++  +G+ Y +KY   ESLK+LRYGK+MIM DQD DGSHIKGL++NF H  WP LL+ +F EQFITPI+KAFK+ Q + FYS      W + TPD +KWR+KYYKGLGTSTS EAKEYF ++++H   F YSG ED   + + F + ++ +RKEW+  W++  K   +  +DE  ++ K    I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+  T+I+LAQD+VGSNNINLL+P G FGTR+ GGKD+AS RYI T+L                             WYAPIIP VLING +G+GTGW + IPN+NP  +I+NL+ ++N   P++M PWYRNF G+I E  + KY   G+   L+  TLE+ ELPI + T  YKE ++ E+  +    + + + DY++ NTD  VRF++ +      +       +   L + ++ +NM+LFDE   I++Y+  +EIL  FFK RL IY KRK++ +  + A+A K +NQ RFI  K  GK+   N         L    +DSDP+K W+++++K   I   +   +   E+S   DFGYL  M + + T +K + L      KL E +++  +SP+
Sbjct:   13 ESIEKRYLKKTQLEHILLRPDSYVGSIKPEEKALWIFDSEKNCMVEKRITYNPGLYKIYDEILVNASDNKIRDRKMSCIRIDINGPKNMIRIWNNGKGIPVVMHKDVNVHVPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSNEFILETSNKEYGKSFKQTWTKNMGVASDPIISSCQKEDFTCVTFYPDLKRFNMSHLDDETIALFSRRAYDIAACTNGIVVYLNGQQIPVKNFKDYVELYTKNCLDSNEEELKVIYEKFGDRWEVAMTTSLNDNFCQVSFVNSIATTKGGTHVNHITDQAAVKLLEIAKKKIKSDKQAVKLKVAQVKMNMWVFVKCLIENPSFDSQTKENMTLNAKDFGSTCALTDKFISQVAKCGIVEKI-TMWAMFKNQALLDKKCSKTKHTKLKDIPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLRGKLLNVREAGVKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQRNTPDSNKWRLKYYKGLGTSTSKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASLMSTIINLAQDFVGSNNINLLMPNGQFGTRLAGGKDSASPRYICTQLK----------------------------WYAPIIPMVLINGCDGIGTGWSSKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGKVICENVKIAVLIDKLVAAKYDSDPVKAWQKSVEKLLAIDKGEEENQEDIEDSNKPDFGYLTQMQILTLTAEKKDALLKERDEKLKELDIIRNKSPQ 1120
[Close]
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037559.1 (SMESG000037559.1)

HSP 1 Score: 985.712 bits (2547), Expect = 0.000e+0
Identity = 516/1148 (44.95%), Postives = 738/1148 (64.29%), Query Frame = 1 
Query:  157 ILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDS--QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKE--DAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----------DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            + E+IEK YQKKT +EHIL RPDSYVGSI K  K  W+FD  +N+++EK+I Y PAL+KIFDEILVNASDNK RD +M+ I+I+++   N + I N+G GIPV +H    +YIPT+IFG LLTS+N++D  ++ TGGRNG+GAKLCN+FS  F +ETSS+  G  +KQTW+NNM    +P I KA   DFT +TF PDL RF M  LD DI+ALF RRA+DIA+  + ++++ N  QI + +FK YV+LY     D N+   + ++ +     EVAVT S + +F+Q+SFVN I T  GG HVN   ++L   +++K +  +K+   A  ++P Q+K ++WIFV  ++ NP F+SQ+KE +T     F S+  L++KF++ +  CG++E++ +M  + K     D   S  K   + D+ KLDDA  AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R    +++  N +  +++  +G+ Y +KY   ESLK+LRYGK+MIM DQD DGSHIKGL++NF H  WP LL+ +F EQFITPI+KAFK+ Q + FYS      W K TP  ++WR+KYYKGLGTST  EAKEYF ++++H   F YSG ED   + + F + ++ +RKEW+  W++  K   +  +DE  ++ K    I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+  T+I+LAQD+VGSNNINLL+P G FGTR+ G K    A ++ T    +++++             DDNQ+IEP WYAPIIP VLING +G+GTGW + IPN+NP  +I+NL+ ++N   P++M PWYRNF G+I E  + KY   G+   L+  TLE+ ELPI + T  YKE ++ E+  +    + + + DY++ NTD  VRF++ +      +       +   L + ++ +NM+LFDE   I++Y+  +EIL  FFK RL IY KRK++ +  + A+A K +NQ RFI  K  G +   N         L    +DSDP+K W +        F+ + +     E+             DFGYL  M + + T +K E L      KL E   +  +SP
Sbjct:   14 VPEDIEKLYQKKTQLEHILLRPDSYVGSIKKEDKLMWVFDDEKNEMVEKKITYNPALYKIFDEILVNASDNKIRDSKMTTIRIDIDSKMNMVRIWNNGRGIPVTIHKEHQVYIPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSSEFVLETSSKEYGKSFKQTWSNNMNDCFDPEISKAAKEDFTCVTFYPDLKRFSMTRLDEDIVALFSRRAYDIAACTQGITVFLNGKQINVKTFKDYVDLYTKHVLDANEEPLKVVYESYGKRWEVAVTTSVNETFSQVSFVNSIATTKGGTHVNYLADQLAAKILEKAKKKIKDDKQAVKLKPAQVKMNMWIFVRCLIENPSFDSQTKENMTLNQKDFGSECTLNEKFISLVAKCGIVEKL-TMWTLFKNQALLDKKCSKTKQTKLKDMPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLKGKLLNVREASAKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQKVTPGANQWRLKYYKGLGTSTDKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASLMSTIINLAQDFVGSNNINLLMPNGQFGTRLAGAK---IALHLVT--YAVLKYLL------------DDNQSIEPEWYAPIIPMVLINGCDGIGTGWSSKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGIIICENVKIAVLIDKLVAAKYDSDPVKAWMK--------FNANKLTIEKAEDEEDEEAIEDSGKPDFGYLTQMQILTLTAEKKEALLKERDEKLEELMRIKNKSP 1134
[Close]
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037565.1 (SMESG000037565.1)

HSP 1 Score: 979.548 bits (2531), Expect = 0.000e+0
Identity = 512/1138 (44.99%), Postives = 735/1138 (64.59%), Query Frame = 1 
Query:  163 ENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDSQF--IHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPN--QIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY--DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504
            E+IEK Y KKT +EHIL RPDSYVGSI    K+ WIFD  +N ++EK I Y P L+KI+DEILVNASDNK RD +MS I+I++N  +N I I N+G GIPVV+H   N+++PT+IFG LLTS+N++D  ++ TGGRNG+GAKLCN+FS  F +ETS++  G  +KQTWT NM   ++P+I   Q  DFT +TF PDL RF M +LD + IALF RRA+DIA+    + +Y N  QIP+ +FK YVELY     D+N+ +   I+    +  EVA+T S + +F Q+SFVN I T  GG HVN   ++    L++  +  +K D + ++    Q+K ++W+FV  ++ NP F+SQ+KE +T     F S   L+DKF++ +  CG++E+I +M  M K     D   S  K   + DI KLDDA  AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R    +++  N +  +++  +G+ Y +KY   ESLK+LRYGK+MIM DQD DGSHIKGL++NF H  WP LL+ +F EQFITPI+KAFK+ Q + FYS      W + TPD +KWR+KYYKGLGTSTS EAKEYF ++++H   F YSG ED   + + F + ++ +RKEW+  W++  K   +  +DE  ++ K    I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+  T+I+LAQD+VGSNNINLL+P G FGTR+ GGKD+AS RYI T+LS + + IF           +DD   ++  W       + ++  NG+   ++  IPN+NP  +I+NL+ ++N   P++M PWYRNF G+I E  + KY   G+   L+  TLE+ ELPI + T  YKE ++ E+  +    + + + DY++ NTD  VRF++ +      +       +   L + ++ +NM+LFDE   I++Y+  +EIL  FFK RL IY KRK++ +  + A+A K +NQ RFI  K  GK+   N         L    +DSDP+K W+++++K   I   +   +   E+S   DFGYL  M + + T +K + L      KL E +++  +SP+
Sbjct:   13 ESIEKRYLKKTQLEHILLRPDSYVGSIKPEEKALWIFDSEKNCMVEKRITYNPGLYKIYDEILVNASDNKIRDRKMSCIRIDINGPKNMIRIWNNGKGIPVVMHKDVNVHVPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSNEFILETSNKEYGKSFKQTWTKNMGVASDPIISSCQKEDFTCVTFYPDLKRFNMSHLDDETIALFSRRAYDIAACTNGIVVYLNGQQIPVKNFKDYVELYTKNCLDSNEEELKVIYEKFGDRWEVAMTTSLNDNFCQVSFVNSIATTKGGTHVNHITDQAAVKLLEIAKKKIKSDKQAVKLKVAQVKMNMWVFVKCLIENPSFDSQTKENMTLNAKDFGSTCALTDKFISQVAKCGIVEKI-TMWAMFKNQALLDKKCSKTKHTKLKDIPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLRGKLLNVREAGVKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQRNTPDSNKWRLKYYKGLGTSTSKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASLMSTIINLAQDFVGSNNINLLMPNGQFGTRLAGGKDSASPRYICTQLSKLTKLIF----------HHDDEAVLKICWMT-----INLSNQNGMHQLFRCKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGKVICENVKIAVLIDKLVAAKYDSDPVKAWQKSVEKLLAIDKGEEENQEDIEDSNKPDFGYLTQMQILTLTAEKKDALLKERDEKLKELDIIRNKSPQ 1133
[Close]
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037559.1 (SMESG000037559.1)

HSP 1 Score: 958.362 bits (2476), Expect = 0.000e+0
Identity = 506/1148 (44.08%), Postives = 722/1148 (62.89%), Query Frame = 1 
Query:  157 ILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDS--QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKE--DAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----------DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501
            + E+IEK YQKKT +EHIL RPDSYVGSI K  K  W+FD  +N+++EK+I Y PAL+KIFDEILVNASDNK RD +M+ I+I+++   N + I N+G GIPV +H    +YIPT+IFG LLTS+N++D  ++ TGGRNG+GAKLCN+FS  F +ETSS+  G  +KQTW+NNM    +P I KA   DFT +TF PDL RF M  LD DI+ALF RRA+DIA+  + ++++ N  QI + +FK YV+LY     D N+   + ++ +     EVAVT S + +F+Q+SFVN I T  GG HVN   ++L   +++K +  +K+   A  ++P Q+K ++WIFV  ++ NP F+SQ+KE +T     F S+  L++KF++ +  CG++E++ +M  + K     D   S  K   + D+ KLDDA  AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R    +++  N +  +++  +G+ Y +KY   ESLK+LRYGK+MIM DQD DGSHIKGL++NF H  WP LL+ +F EQFITPI+KAFK+ Q + FYS      W K TP  ++WR+KYYKGLGTST  EAKEYF ++++H   F YSG ED   + + F + ++ +RKEW+  W++  K   +  +DE  ++ K    I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+                                GKD+AS RYI T+LS + + IF   D+  L+   DDNQ+IEP WYAPIIP VLING +G+GTGW + IPN+NP  +I+NL+ ++N   P++M PWYRNF G+I E  + KY   G+   L+  TLE+ ELPI + T  YKE ++ E+  +    + + + DY++ NTD  VRF++ +      +       +   L + ++ +NM+LFDE   I++Y+  +EIL  FFK RL IY KRK++ +  + A+A K +NQ RFI  K  G +   N         L    +DSDP+K W +        F+ + +     E+             DFGYL  M + + T +K E L      KL E   +  +SP
Sbjct:   14 VPEDIEKLYQKKTQLEHILLRPDSYVGSIKKEDKLMWVFDDEKNEMVEKKITYNPALYKIFDEILVNASDNKIRDSKMTTIRIDIDSKMNMVRIWNNGRGIPVTIHKEHQVYIPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSSEFVLETSSKEYGKSFKQTWSNNMNDCFDPEISKAAKEDFTCVTFYPDLKRFSMTRLDEDIVALFSRRAYDIAACTQGITVFLNGKQINVKTFKDYVDLYTKHVLDANEEPLKVVYESYGKRWEVAVTTSVNETFSQVSFVNSIATTKGGTHVNYLADQLAAKILEKAKKKIKDDKQAVKLKPAQVKMNMWIFVRCLIENPSFDSQTKENMTLNQKDFGSECTLNEKFISLVAKCGIVEKL-TMWTLFKNQALLDKKCSKTKQTKLKDMPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLKGKLLNVREASAKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQKVTPGANQWRLKYYKGLGTSTDKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASL------------------------------IWGKDSASPRYICTQLSKLTKLIFHHDDEAVLKYLLDDNQSIEPEWYAPIIPMVLINGCDGIGTGWSSKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGIIICENVKIAVLIDKLVAAKYDSDPVKAWMK--------FNANKLTIEKAEDEEDEEAIEDSGKPDFGYLTQMQILTLTAEKKEALLKERDEKLEELMRIKNKSP 1121
The following BLAST results are available for this feature:
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TOP2A0.000e+046.23DNA topoisomerase II alpha [Source:HGNC Symbol;Acc... [more]
TOP2B0.000e+045.79DNA topoisomerase II beta [Source:HGNC Symbol;Acc:... [more]
TOP2B0.000e+045.79DNA topoisomerase II beta [Source:HGNC Symbol;Acc:... [more]
TOP2B0.000e+045.96DNA topoisomerase II beta [Source:HGNC Symbol;Acc:... [more]
TOP2A6.944e-4354.55DNA topoisomerase II alpha [Source:HGNC Symbol;Acc... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
top-20.000e+043.79DNA topoisomerase 2 top-2 [Source:UniProtKB/Swiss... [more]
R05D3.120.000e+040.07Putative DNA topoisomerase 2, mitochondrial [Sour... [more]
cin-40.000e+039.87DNA topoisomerase-like protein cin-4 [Source:UniP... [more]
R05D3.124.179e-17441.87Putative DNA topoisomerase 2, mitochondrial [Sour... [more]
R05D3.124.179e-17441.87Putative DNA topoisomerase 2, mitochondrial [Sour... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Top20.000e+045.24gene:FBgn0284220 transcript:FBtr0332320[more]
Top20.000e+045.24gene:FBgn0284220 transcript:FBtr0081287[more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
top2b0.000e+046.30DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
top2a0.000e+045.91DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GE... [more]
top2a2.175e-8441.88DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GE... [more]
top2b1.894e-2651.04DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TOP2B0.000e+046.32DNA topoisomerase II beta [Source:NCBI gene;Acc:77... [more]
TOP2B0.000e+046.32DNA topoisomerase II beta [Source:NCBI gene;Acc:77... [more]
TOP2B0.000e+046.32DNA topoisomerase II beta [Source:NCBI gene;Acc:77... [more]
TOP2B0.000e+046.32DNA topoisomerase II beta [Source:NCBI gene;Acc:77... [more]
TOP2B0.000e+046.32DNA topoisomerase II beta [Source:NCBI gene;Acc:77... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Top2a0.000e+046.32topoisomerase (DNA) II alpha [Source:MGI Symbol;Ac... [more]
Top2b0.000e+045.28topoisomerase (DNA) II beta [Source:MGI Symbol;Acc... [more]
Top2b7.439e-2635.00topoisomerase (DNA) II beta [Source:MGI Symbol;Acc... [more]
back to top
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O46374|TOP2A_PIG0.000e+046.50DNA topoisomerase 2-alpha OS=Sus scrofa OX=9823 GN... [more]
sp|O42130|TOP2A_CHICK0.000e+045.81DNA topoisomerase 2-alpha OS=Gallus gallus OX=9031... [more]
sp|P11388|TOP2A_HUMAN0.000e+046.23DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 ... [more]
sp|Q01320|TOP2A_MOUSE0.000e+046.32DNA topoisomerase 2-alpha OS=Mus musculus OX=10090... [more]
sp|P41515|TOP2A_CRIGR0.000e+046.31DNA topoisomerase 2-alpha OS=Cricetulus griseus OX... [more]
back to top
BLAST of DNA topoisomerase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K3ERS30.000e+045.79DNA topoisomerase 2 OS=Mesocestoides corti OX=5346... [more]
A0A5C6NGH80.000e+047.11DNA topoisomerase 2 OS=Takifugu flavidus OX=433684... [more]
A0A3Q0RLH90.000e+046.88DNA topoisomerase 2 OS=Amphilophus citrinellus OX=... [more]
A0A2I4CPW40.000e+046.68DNA topoisomerase 2-beta OS=Austrofundulus limnaeu... [more]
A0A3Q0RFV20.000e+046.88DNA topoisomerase 2 OS=Amphilophus citrinellus OX=... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
top2b0.000e+047.00DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
top2a0.000e+044.22DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GE... [more]
top2a0.000e+044.22DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GE... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
top2a0.000e+045.43DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GE... [more]
ENSPMAT00000007762.15.683e-9947.85pep scaffold:Pmarinus_7.0:GL492656:1017:4077:-1 ge... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
TOP20.000e+041.07Topoisomerase II; relieves torsional strain in DNA... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO448135.994e-14046.30DNA topoisomerase 2 [Source:UniProtKB/TrEMBL;Acc:... [more]
EDO448112.406e-6737.39Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO295472.746e-5146.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO448122.375e-3450.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO256985.147e-1532.53Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
top2b0.000e+046.57DNA topoisomerase II beta [Source:NCBI gene;Acc:10... [more]
top2a0.000e+044.44DNA topoisomerase II alpha [Source:NCBI gene;Acc:1... [more]
top2b0.000e+044.73DNA topoisomerase II beta [Source:NCBI gene;Acc:10... [more]
top2b7.727e-7239.16DNA topoisomerase II beta [Source:NCBI gene;Acc:10... [more]
top2a3.925e-6753.57DNA topoisomerase II alpha [Source:NCBI gene;Acc:1... [more]
back to top
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000064303.10.000e+095.59SMESG000064303.1[more]
SMESG000037565.10.000e+045.78SMESG000037565.1[more]
SMESG000037559.10.000e+044.95SMESG000037559.1[more]
SMESG000037565.10.000e+044.99SMESG000037565.1[more]
SMESG000037559.10.000e+044.08SMESG000037559.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001991 ID=SMED30001991|Name=DNA topoisomerase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=3743bp
ATTTTTTAACTTTTTTAAGAGTTTTAATTTATATATTATACAATTCTATT
AAAACTGGCATCTTCAAGATATTTATTAAAATATTTTAATAATATTTCTC
ATAGCCTTAGCATACGATGTAAATATTCTAATTTGCCAACAACCACCAAA
AGCTTGATATTGGAAAATATTGAAAAAACTTATCAAAAGAAGACTCTTAT
TGAACATATATTACATAGACCAGATTCATATGTTGGTTCAATTAATAAAA
GTATAAAGTCACAATGGATTTTCGACAAAAGTCAAAATAAAATTATTGAA
AAAGAAATTATGTATGTTCCAGCACTTTTCAAAATATTTGATGAAATTTT
AGTTAACGCCTCTGATAATAAACGCCGGGACGATCGCATGTCATATATAA
AAATAAACGTAAATAGAGATGAAAATGAAATATCAATAAGTAATGATGGG
AGTGGGATTCCTGTAGTTTTGCACAGTACAGAAAACATGTATATCCCAAC
ACTCATTTTTGGAAACTTATTAACATCCAGTAATTACGATGATTCGTTAG
AAAAATTCACCGGCGGTAGAAATGGGTTTGGTGCAAAGTTATGTAATTTG
TTTAGCAAGAGTTTCTCAGTCGAAACTTCTTCTGAGATTACTGGATATCG
GTATAAGCAAACTTGGACTAATAATATGACGCAATTTACGGAACCGGTAA
TTGAAAAAGCTCAAGGTCCTGATTTCACGACAATCACATTTAAACCAGAT
TTAACAAGATTTAAAATGGATAATCTTGATACAGACATAATTGCATTATT
CCATCGCAGAGCGTTTGACATTGCCTCAAACTTGAAAAATGTTTCCATTT
ATTTCAATGATACTCAAATACCGATTACGTCTTTTAAACAATATGTTGAA
TTGTATGACAATAACGATTCTCAATTTATCCACAACACAATTAACAATTC
ATTGGAAGTTGCTGTGACGTTGTCAACGAGTTATTCTTTCACACAAATCA
GTTTTGTCAACGGTATTAATACTGTTAACGGTGGACTGCATGTTAACAGT
TTCGTAAATAAACTCGTCCAAGTTCTTGTGCAGAAATTTGAGACAATAAT
GAAAGAAGACGCTAAATATATAAGGCCCAATCAAATTAAAAATTCACTTT
GGATTTTTGTCAATTCAGTCGTCAGTAATCCATGTTTTGAATCTCAATCC
AAAGAATATTTAACATCTCTACCGAATAAATTTTCATCTCAAATACTGTT
GTCAGACAAATTTGTCAATAATATCATCGACTGTGGTCTTCTGGAAAGAA
TCCAATCCATGATGAATATGAAAAAAGATTTTCCGAAATCGCTAAGAAAA
GTTAATAATATATTGGATATTGTAAAATTAGACGATGCATTACACGCTGG
CACCAAATTAAGTGGGGAATGTACATTAATTTTGACTGAAGGGGACTCTG
CAAAATCTTTTGCTATGTCAGGTCTCGATGTTTTGGGGAAAGATTATTTT
GGCGTATTTTCTTTACAGGGGAAAAATCTAAATACTCGTAATGTAAAGGA
AAGAAAAATGCTGATGAATAAACAATATAAAGATGTAGTTGTTAGTTTAG
GCATAAGTTATAAAAAAAAATATTTGACTAAAGAATCGTTGAAGTCATTG
AGATATGGAAAAGTTATGATTATGGCTGATCAAGATCCAGATGGATCACA
CATTAAAGGCTTGATATTGAATTTCTTTCATCATAATTGGCCTGAATTGT
TGCAACTAGATTTCTTTGAACAATTTATCACTCCAATCATGAAAGCTTTC
AAAGACACTCAGTGCATTCCATTCTATTCACATAATGCATATCAAAACTG
GGTGAAGGCAACACCAGATTATAGCAAATGGAGAATTAAATATTACAAGG
GTCTTGGTACATCAACCAGTGCTGAAGCAAAAGAATATTTTAGAAATATT
GATCAACATAGAAAAAGCTTTCATTACTCTGGTTCGGAAGATGACTATTT
AATGAAAATGGTATTTGAAAGAGAACAATCAACAAAGAGAAAAGAATGGA
TTTTGCAATGGTTGAAAAAACGCAAAGGACTACTGAAAAAAAATATTGAT
GAAGAAAATATATTTGTTAAAAATAAAACATCGATTAGTTACAAAGATTT
TATTAATAAAGAATTAATAGTTTATAGTAATCAAGATAATGTGCGAAATA
TTCCATCGATCATGGACGGACTCAAACCATCTCAAAGAAAAATTATTTAC
ACGTGTCTTAAAAGAAACTTTATAAAAGATGTCAAAGTGACTCAGTTATC
GGGATCTGTGTCTGAACTAACCAATTATCACCATTCCGAGAAAAGTATTT
ACGATACTGTCATACATTTGGCTCAGGATTATGTAGGTAGCAACAATATA
AACCTTTTGGTACCTGTTGGTCATTTTGGTACCAGAGTTTATGGTGGTAA
AGACAATGCTTCTGCCCGTTATATTAGCACAAAATTATCACCGATTGTCA
GGTTTATTTTTCCAGCTGCAGATGATAATTTTCTCCAATGTAAATATGAT
GATAACCAGACTATTGAACCAATATGGTATGCTCCAATAATTCCTTTCGT
TCTTATCAACGGTGCTAATGGCCTTGGCACTGGATGGAAAACATTTATTC
CGAATTACAATCCTTTTCAAATTATAGAAAATCTGAGATTGTTACTGAAT
GACAAACCACCTATTCAGATGGTTCCTTGGTATCGAAACTTTAAAGGTTC
AATCAATGAATCAGATCAGAAAAAATATAAAACTACTGGAAAATTTCGAA
TATTAAATTCAAAAACATTAGAAGTGTATGAATTACCAATTGGAATATCA
ACTCAAAAGTATAAAGAATATATTGTTAATGAAATGCTGGTAAATTCAAA
AAGTATTGTCCGTGACTATGAAGACCGTAATACAGACACAGAAGTGAGGT
TTATCATTCACTTGAAATTAGACTTGAAAGAAATTCGATTAAATCTTGAT
CAATTATTAAATTTGAGCAGCGAGATTTCGACAACAAATATGGTTTTGTT
TGATGAACATAGTGAAATAAAGCGATATAGCACTCCAGTGGAGATATTGG
TGGAATTCTTTAAAGCTCGTCTCATAATTTATGAAAAGAGAAAAGATCAT
TTTGTACAGAAGATTTTGGCCGAAGCAAAAAAGTCTGAAAATCAATTGCG
ATTTATCAAAGATGCTGGAAAATTGAATTTGCGAAATTTTAATGAACATG
AAGCAAATTTACTACTGAAACAAAATAGTTTTGATTCAGATCCAATAAAA
ATATGGGAGCAAGCGTTAAAGAAAGAACATAGAATATTTGATGAAGACCC
AGTTAAAAAGGGTATATTTGAAGAAAGTTATGATTTTGGTTATTTATTGA
ATATGCCCGTTCGAAGTTTTACTAAAGATAAGATAGAAAATCTCAATAAT
TTATTCAAATCCAAGTTATTAGAAGCTGAAATGCTGAATAGGAGATCTCC
TCGAGAAATATGGTTGGAAGAGCTGCAAATTTTAGAGGAAAAAATAAAAA
ATTTATATGCTGATACAGAATTACAATAAAGCTTTGCCATATTTCATAAT
GTTTAATTTGCTGTTGATTTGAGAAATCGATTTATTGAGAATGCATTTGA
ATTTATTTTAAATAATTGTTTGTACAATAAAGATTTCAATTTATAATAGT
TGATTTTCATTGTATCTTTGTTTAAATATTTAAACCAGTCCAG
back to top

protein sequence of SMED30001991-orf-1

>SMED30001991-orf-1 ID=SMED30001991-orf-1|Name=SMED30001991-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1090bp
MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGI
PVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSK
SFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTR
FKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYD
NNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVN
KLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEY
LTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNN
ILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVF
SLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYG
KVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDT
QCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQH
RKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEEN
IFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCL
KRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLL
VPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQ
TIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKP
PIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQK
YKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLL
NLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQ
KILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWE
QALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFK
SKLLEAEMLNRRSPREIWLEELQILEEKIKNLYADTELQ*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0007412axon target recognition
GO:0010842retina layer formation
GO:0031290retinal ganglion cell axon guidance
GO:0006265DNA topological change
GO:0006259DNA metabolic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036890HATPase_C_sf
IPR001154TopoII_euk
IPR001241Topo_IIA
IPR002205Topo_IIA_A/C
IPR013757Topo_IIA_A_a_sf
IPR024946Arg_repress_C-like
IPR013758Topo_IIA_A/C_ab
IPR006171TOPRIM_domain
IPR014721Ribosomal_S5_D2-typ_fold_subgr
IPR031660TOPRIM_C
IPR013759Topo_IIA_B_C
IPR003594HATPase_C
IPR013506Topo_IIA_bsu_dom2
IPR018522TopoIIA_CS
IPR020568Ribosomal_S5_D2-typ_fold
IPR013760Topo_IIA-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0005524ATP binding
GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0000166nucleotide binding
GO:0003916DNA topoisomerase activity
GO:0016853isomerase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 1042..1062
NoneNo IPR availableCOILSCoilCoilcoord: 1065..1089
NoneNo IPR availableCOILSCoilCoilcoord: 949..969
NoneNo IPR availablePRINTSPR00418TPI2FAMILYcoord: 526..542
score: 54.45
coord: 446..462
score: 62.55
coord: 484..496
score: 30.58
coord: 5..20
score: 49.16
coord: 373..387
score: 58.86
coord: 85..99
score: 57.72
coord: 464..481
score: 49.8
coord: 231..244
score: 58.1
coord: 42..55
score: 50.44
NoneNo IPR availableGENE3DG3DSA:3.30.1490.30coord: 492..535
e-value: 9.4E-102
score: 341.7
NoneNo IPR availableGENE3DG3DSA:3.30.1360.40coord: 811..909
e-value: 3.2E-156
score: 522.6
NoneNo IPR availablePANTHERPTHR10169DNA TOPOISOMERASE/GYRASEcoord: 2..1084
NoneNo IPR availableCDDcd16930HATPase_TopII-likecoord: 2..147
e-value: 2.41343E-75
score: 243.014
IPR001154DNA topoisomerase II, eukaryotic-typePRINTSPR01158TOPISMRASEIIcoord: 734..754
score: 51.07
coord: 918..944
score: 40.49
coord: 485..496
score: 62.64
coord: 371..378
score: 94.83
coord: 465..480
score: 67.03
coord: 657..680
score: 53.45
coord: 839..853
score: 54.02
coord: 356..366
score: 65.2
coord: 532..544
score: 78.25
coord: 704..726
score: 67.02
IPR001241DNA topoisomerase, type IIASMARTSM00433topII5coord: 5..586
e-value: 1.5E-201
score: 685.6
IPR002205DNA topoisomerase, type IIA, subunit A/C-terminalSMARTSM00434topIV4coord: 609..1070
e-value: 4.5E-114
score: 394.9
IPR002205DNA topoisomerase, type IIA, subunit A/C-terminalPFAMPF00521DNA_topoisoIVcoord: 629..1073
e-value: 1.2E-107
score: 360.5
IPR006171TOPRIM domainPFAMPF01751Toprimcoord: 373..474
e-value: 5.0E-7
score: 29.9
IPR006171TOPRIM domainPROSITEPS50880TOPRIMcoord: 371..488
score: 14.949
IPR036890Histidine kinase/HSP90-like ATPase superfamilyGENE3DG3DSA:3.30.565.10coord: 1..202
e-value: 1.5E-77
score: 262.3
IPR036890Histidine kinase/HSP90-like ATPase superfamilySUPERFAMILYSSF55874ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinasecoord: 2..188
IPR013759DNA topoisomerase, type IIA, subunit B, C-terminalGENE3DG3DSA:3.40.50.670coord: 357..626
e-value: 9.4E-102
score: 341.7
IPR013758DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-betaGENE3DG3DSA:3.90.199.10coord: 627..1073
e-value: 3.2E-156
score: 522.6
IPR003594Histidine kinase/HSP90-like ATPasePFAMPF02518HATPase_ccoord: 5..149
e-value: 7.7E-11
score: 42.5
IPR014721Ribosomal protein S5 domain 2-type fold, subgroupGENE3DG3DSA:3.30.230.10coord: 206..331
e-value: 7.7E-32
score: 111.2
IPR031660C-terminal associated domain of TOPRIMPFAMPF16898TOPRIM_Ccoord: 489..627
e-value: 1.5E-39
score: 135.2
IPR013757Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamilyGENE3DG3DSA:1.10.268.10coord: 945..1062
e-value: 3.2E-156
score: 522.6
IPR013506DNA topoisomerase, type IIA, subunit B, domain 2PFAMPF00204DNA_gyraseBcoord: 193..323
e-value: 5.4E-19
score: 68.3
IPR018522DNA topoisomerase, type IIA, conserved sitePROSITEPS00177TOPOISOMERASE_IIcoord: 375..383
IPR020568Ribosomal protein S5 domain 2-type foldSUPERFAMILYSSF54211Ribosomal protein S5 domain 2-likecoord: 181..335
IPR013760DNA topoisomerase, type IIA-like domain superfamilySUPERFAMILYSSF56719Type II DNA topoisomerasecoord: 350..1081