DNA topoisomerase 2
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001991 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2A (DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989]) HSP 1 Score: 1041.57 bits (2692), Expect = 0.000e+0 Identity = 528/1142 (46.23%), Postives = 758/1142 (66.37%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+S +KQTW +NM + E ++ G D+T ITF+PDL++FKM +LD DI+AL RRA+DIA + K+V ++ N ++P+ F+ YV++Y N + IH +N+ EV +T+S F QISFVN I T GG HV+ +++V LV ++K+ K ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T P F S LS+KF+ I CG++E I + + K S K N I I KLDDA AG + S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+K K+ Q + FYS ++ W +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F ++Q RKEW+ +++ R+ + E+ ++ + T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP DD+ L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ +I+ N+R L++ + P+ M+P Y+NFKG+I E +Y +G+ ILNS T+E+ ELP+ TQ YKE ++ ML ++ ++ DY + +TDT V+F++ + KL E R+ L ++ L + ++ +MVLFD +K+Y T ++IL +FF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q +DSDP+K W++A +K + + E D F YLL+MP+ TK+K + L L K E + L R+SP Sbjct: 29 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVTKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSP 1163
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2B (DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990]) HSP 1 Score: 1026.93 bits (2654), Expect = 0.000e+0 Identity = 522/1140 (45.79%), Postives = 748/1140 (65.61%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ + +E+ +VP L+KIFDEILVNA+DNK+RD M+ IK++++ + N ISI N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNM + +E I+ G D+T ITF+PDL++FKM+ LD DI+AL RRA+D+A + + V + FN ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+F+N ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+KA K+ Q + FYS + W K + W+IKYYKGLGTST+ EAKEYF ++++HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+ YDDNQ +EP WY PIIP VLINGA G+GTGW +PNY+ +I+ N+R +L+ P M+P Y+NFKG+I E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ V + AE+ K NQ RFI K GK+ + N ++ + +L Q ++SDP+K W++A +K E + +D DF Y+LNM + S TK+K+E L +K E L R+SP Sbjct: 50 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSP 1181
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2B (DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990]) HSP 1 Score: 1026.54 bits (2653), Expect = 0.000e+0 Identity = 522/1140 (45.79%), Postives = 748/1140 (65.61%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ + +E+ +VP L+KIFDEILVNA+DNK+RD M+ IK++++ + N ISI N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNM + +E I+ G D+T ITF+PDL++FKM+ LD DI+AL RRA+D+A + + V + FN ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+F+N ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+KA K+ Q + FYS + W K + W+IKYYKGLGTST+ EAKEYF ++++HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+ YDDNQ +EP WY PIIP VLINGA G+GTGW +PNY+ +I+ N+R +L+ P M+P Y+NFKG+I E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ V + AE+ K NQ RFI K GK+ + N ++ + +L Q ++SDP+K W++A +K E + +D DF Y+LNM + S TK+K+E L +K E L R+SP Sbjct: 45 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSP 1176
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2B (DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990]) HSP 1 Score: 1012.68 bits (2617), Expect = 0.000e+0 Identity = 512/1114 (45.96%), Postives = 734/1114 (65.89%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFT 3423 ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ + +E+ +VP L+KIFDEILVNA+DNK+RD M+ IK++++ + N ISI N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNM + +E I+ G D+T ITF+PDL++FKM+ LD DI+AL RRA+D+A + + V + FN ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+F+N ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+KA K+ Q + FYS + W K + W+IKYYKGLGTST+ EAKEYF ++++HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+ YDDNQ +EP WY PIIP VLINGA G+GTGW +PNY+ +I+ N+R +L+ P M+P Y+NFKG+I E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ V + AE+ K NQ RFI K GK+ + N ++ + +L Q ++SDP+K W++A +K E + +D DF Y+LNM + S T Sbjct: 45 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLT 1150
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Match: TOP2A (DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989]) HSP 1 Score: 154.836 bits (390), Expect = 6.944e-43 Identity = 72/132 (54.55%), Postives = 98/132 (74.24%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFT 561 ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K T Sbjct: 17 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 147
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: top-2 (DNA topoisomerase 2 top-2 [Source:UniProtKB/Swiss-Prot;Acc:Q23670]) HSP 1 Score: 1003.43 bits (2593), Expect = 0.000e+0 Identity = 504/1151 (43.79%), Postives = 757/1151 (65.77%), Query Frame = 1 Query: 169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKS-QWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYD---NNDSQ---FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLN----LRNFNEHEANLLLKQNSFDSDPIKIWEQALK-KEHR-----IFDEDPVKKGIFEES--------------YDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRS 3498 IE YQKK+ +EHIL RPD+Y+GS+ + K+ W+++ ++K+ +++I YVP L+KI+DEILVNA+DNK+RD +M+ IKI +N+++NEIS+ N+G GIPV H E +Y+P LIFG LLTSSNY+D +K TGGRNG+GAKLCN+FS F++ETSS +KQTW NMT+ EP I K+ DFT ITF PDL +FKM LD DI L RRA+D+A + K V+++ N +IPI F+ YV++Y NN+ + + + + +VA+ LS F Q+SFVN I T GG HV+ +++V + + + + + I+P QIKN +W+FVN ++ NP F+SQ+KE +T +F S +LS+KF G+ + + S + K+ + S K + + I KL+DA AGTK S +CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R +++ N + ++ LG+ YKKKY T++ K+LRYGK+M+MADQD DGSHIKGL++NF HH WP L+Q +F E+FITPI+KA K + + FYS Y W T ++ ++IKYYKGLGTSTS EAKEYF ++ +HR F Y+G++DD + M F +++ +RK+W+ +W++++K ++ + EE ++ K+ +++KDF+N+EL+++SN DN R+IP ++DG KP QRK+++ C KR ++VKV QL+G+V+E++ YHH E+S+ T+++LAQDYVGSNNINLL+P+G FGTR+ GGKD+ASARYI T+LSP+ R +FPA DDN L+ Y++NQ IEP WY PIIP VL+NGA G+GTGW T IPNYNP ++++N++ L+ +P + PWY+NF+G I + D ++ G+ +L+ T+E+ ELPI TQ YKE ++ ++ +S ++ DY++ +TDT V+F++ L KL E +L Q+ L + I+TT MVLFD ++ Y++P I EF+ +R Y +RK++ + + A++K+ NQ RFI K+N L N + +L + FD+DP+K W++ K KE R DED + EE D+ YL+ M + ++++ L + K+ E ++ +++ Sbjct: 63 IEDIYQKKSQLEHILLRPDTYIGSVEHTEKTPMWVYNMEESKLEQRDISYVPGLYKIYDEILVNAADNKQRDPKMNTIKITINKEKNEISVYNNGKGIPVTQHKVEKVYVPELIFGTLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTKFTLETSSRDYKSAFKQTWIKNMTRDEEPKIVKSTDEDFTKITFSPDLAKFKMKELDDDICHLMARRAYDVAGSSKGVAVFLNGKRIPIKGFEDYVQMYTSQFNNEGEPLKIAYEQVGDRWQVALALSEK-GFQQVSFVNSIATTKGGRHVDYVADQMVAKFIDSIKRKLTKTSMNIKPFQIKNHMWVFVNCLIENPTFDSQTKETMTLQQKQFGSTCVLSEKFSKAASSVGITDAVMSWVRFKQMDDLNKKCSKTKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPLRGKLLNVREGNMKQIADNAEVNAMIKILGLQYKKKYETEDDFKTLRYGKLMVMADQDQDGSHIKGLVINFIHHFWPSLIQRNFVEEFITPIVKATKGKEEVSFYSLPEYSEWRMNTDNWKSYKIKYYKGLGTSTSKEAKEYFLDMVRHRIRFKYNGADDDNAVDMAFSKKKIEERKDWLSKWMREKKDRKQQGLAEEYLYNKDTRFVTFKDFVNRELVLFSNLDNERSIPCLVDGFKPGQRKVLFACFKRADKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASARYIFTQLSPVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGIGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPSRFACYGEVAVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGCLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFI--LAKINNEIVLENKKKAAIVDVLIKMKFDADPVKKWKEEQKLKELRESGEIELDEDDLAAVAVEEDEAISSAAKAVETKLSDYDYLVGMALIKLSEEEKNKLIKESEEKMAEVRVIEKKT 1210
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: R05D3.12 (Putative DNA topoisomerase 2, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P34534]) HSP 1 Score: 798.89 bits (2062), Expect = 0.000e+0 Identity = 466/1163 (40.07%), Postives = 701/1163 (60.28%), Query Frame = 1 Query: 76 LKYFNNISHSLSI-----RCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSIN-KSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEP-VIE--KAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNL-KNVSIYFNDTQIPITSFKQYVELYDNNDS-QFIHNTINNSLEVAVT---LSTSYSFTQ--ISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIID-CGLLERI-QSMMNM-KKDFPKSLRKVNNILDIVKLDDALHAG-TKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYK-KKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKR-NFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLND-KPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSK-------TLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHL--KLDLKEIRLNLDQLLN---LSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAK--KSENQLRFIKDA--GKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENL 3444 LK+ + SH ++ R +N+P+T S E K Y+KK+ EH+L RPD+Y+G + + + W+ D K+I KE+ Y P L KIFDEILVNA+DNK RD M+ +++ ++R+ IS+ N+GSG+PV +H TE +Y+PTL+FGNL TSSNYDDS K GGRNG+GAKLCN+FSK F VET R++Q W +NM + E V+E D+T + F PDL RF++D L D+I L RR F++A+ L ++V +Y N + + F+ YV++++++ S F+H T + VA S+ +SFVN INT GG HV+ ++K+V ++ ++ + + K ++P IKN+L IF+N ++ NP FESQ+KE LT+ F S K + GL+E I + ++NM KK P V+++ DIVKL+DA AG T + +CTLILTEGDSAK+ A++GL+VLG++ +GVF L+GK LN N+ + + N++ +++ LG+ ++ +T+E SLRYG+++I+ADQD DGSHIKGLI+NF H WP L+ D F + F TP++KA K + F+S N Y+ W + KW+IKYYKGLGTSTS EA+EYF ++D H +F Y+G+ DD ++M F+R++S +RKEWI +R N D+ KT ISY++F++ +L+ + D R+IPS++DGLKPSQRKI++T L + ++KV+QL+G+V+ +YHH E+S+ T+I + Q + GS+N+ LL P+G FGTR GG D ASARYI T L+P R +FP ADD+ LQ ++ +EP W PI+P +LING G+GTGW T I N NP II+ +R ++ ++ P+Y F+G + K+ ++GK +++ + ++E+ ELPIGI T KYKE + +V + ++ ++ +R+T+ V F I L K + ++ + LLN L + + T N VLFD + E+K + EI EFF+ R +YEKR +QK EAK ENQL FI+ G + +R+ ++ L++ F DP+ + KK ++GYLL MPV T D+++ L Sbjct: 10 LKFCISTSHRTTVVLKNTRSFCNNIPST--SFASEAAAK-YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRE---SLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADVE-EGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWI-----RRSENEITNEDD------GKTEISYQEFVDGQLMQFGMVDLKRSIPSLIDGLKPSQRKILWTLLNNMDESTEIKVSQLAGAVAHRQSYHHGEESLVRTIIRMGQTFCGSSNLPLLQPIGQFGTRHEGGNDAASARYIFTALAPTTRLLFPQADDDLLQKNVEEGMVVEPTWLCPIVPLILINGTEGIGTGWSTKIANRNPIDIIDMIRRKIDSISTEYEIPPFYEEFRGKLEVVTPTKFISSGKIQLIRPERKNASTFSIEIVELPIGIWTSKYKEKLSK--IVETLPVL-EFSERHTEKRVHFRITLDRKKSSRFLQKSNSDLLNYFKLRTSL-TENRVLFDRNGELKEFGNISEIAAEFFEVRRDLYEKRLK--IQKEECEAKLIYVENQLNFIEMVTNGTIEIRSMGRNQLEEKLQEMGFRVDPMATIAKNSKK------------------ANYGYLLEMPVSRLTSDEMKRL 1130
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: cin-4 (DNA topoisomerase-like protein cin-4 [Source:UniProtKB/Swiss-Prot;Acc:G5ECQ8]) HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0 Identity = 303/760 (39.87%), Postives = 472/760 (62.11%), Query Frame = 1 Query: 1303 QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDA--GKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALK-KEHR-----IFDEDPVKKGIFEES--------------YDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRS 3498 + M ++ + PK RK + + I KL+DA AGTK S +CTLILTEGDSAK+ A+SGL V+G+D +GVF + K LN ++ ++ + + ++ LG+ Y KKY T++ K+LRYGK++IMA+ D DGS KGL+LNFFH WP L + DF E FITPI KA + + + FYS Y W T ++ + IKYY GLGT TS EAK+ F ++ +HR F Y+G++DD + M F +++ R +++++ ++ + ++ + EE ++ K ++ KDF N E++ N + +IP ++DGLKP QRK+++ C KR ++VKV QL+G+V+E++ YHH E+S+ T+++LAQDYVGS+NINLL+P+G FGTR+ GGKD+ASAR I +LS + R +FPA DDN L+ Y++NQ IEP WY PIIP VL+NGA G GTGW T IPNYNP ++++N++ L+ +P + PWY+NF+G I + D ++ G+ +L+ T+E+ ELPI TQ YKE ++ ++ +S ++ DY++ +TDT V+F++ L KL E +L Q+ L + I+TT MVLFD ++ Y++P I EF+ +R Y +RK++ + + A++K+ NQ RFI K+ L N + +L + FD+DP+K W++ K KE R DED + EE D+ YL+ + + ++++ L + K+ E +L +++ Sbjct: 20 KQMDDLNQKCPK--RKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDLNVNQIADSAEVNAIIKILGLQYTKKYETEDDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVEDFITPIAKATEGKEEVSFYSLPEYSEWRMNTDNWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFSKKKIEARTDYLMKLMQDKNQRKQQGLAEECLYNKETRFVTLKDFFNYEIVCSWN---LHSIPCLVDGLKPGQRKVLFACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILATINNKIVLENKKKTAIVDVLIKMKFDADPVKKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKAVETKLSDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKT 774
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: R05D3.12 (Putative DNA topoisomerase 2, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P34534]) HSP 1 Score: 533.487 bits (1373), Expect = 4.179e-174 Identity = 304/726 (41.87%), Postives = 453/726 (62.40%), Query Frame = 1 Query: 76 LKYFNNISHSLSI-----RCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSIN-KSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEP-VIE--KAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNL-KNVSIYFNDTQIPITSFKQYVELYDNNDS-QFIHNTINNSLEVAVT---LSTSYSFTQ--ISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIID-CGLLERI-QSMMNM-KKDFPKSLRKVNNILDIVKLDDALHAG-TKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKK-YLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQD 2187 LK+ + SH ++ R +N+P+T S E K Y+KK+ EH+L RPD+Y+G + + + W+ D K+I KE+ Y P L KIFDEILVNA+DNK RD M+ +++ ++R+ IS+ N+GSG+PV +H TE +Y+PTL+FGNL TSSNYDDS K GGRNG+GAKLCN+FSK F VET R++Q W +NM + E V+E D+T + F PDL RF++D L D+I L RR F++A+ L ++V +Y N + + F+ YV++++++ S F+H T + VA S+ +SFVN INT GG HV+ ++K+V ++ ++ + + K ++P IKN+L IF+N ++ NP FESQ+KE LT+ F S K + GL+E I + ++NM KK P V+++ DIVKL+DA AG T + +CTLILTEGDSAK+ A++GL+VLG++ +GVF L+GK LN N+ + + N++ +++ LG+ ++ +T+E SLRYG+++I+ADQD DGSHIKGLI+NF H WP L+ D F + F TP++KA K + F+S N Y+ W + KW+IKYYKGLGTSTS EA+EYF ++D H +F Y+G+ DD ++M F+R++S +RKEWI +R N D+ KT ISY++F++ +L+ + D Sbjct: 10 LKFCISTSHRTTVVLKNTRSFCNNIPST--SFASEAAAK-YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRE---SLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADV-EEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWI-----RRSENEITNEDD------GKTEISYQEFVDGQLMQFGMVD 717
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Match: R05D3.12 (Putative DNA topoisomerase 2, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P34534]) HSP 1 Score: 533.487 bits (1373), Expect = 4.179e-174 Identity = 304/726 (41.87%), Postives = 453/726 (62.40%), Query Frame = 1 Query: 76 LKYFNNISHSLSI-----RCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSIN-KSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEP-VIE--KAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNL-KNVSIYFNDTQIPITSFKQYVELYDNNDS-QFIHNTINNSLEVAVT---LSTSYSFTQ--ISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIID-CGLLERI-QSMMNM-KKDFPKSLRKVNNILDIVKLDDALHAG-TKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKK-YLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQD 2187 LK+ + SH ++ R +N+P+T S E K Y+KK+ EH+L RPD+Y+G + + + W+ D K+I KE+ Y P L KIFDEILVNA+DNK RD M+ +++ ++R+ IS+ N+GSG+PV +H TE +Y+PTL+FGNL TSSNYDDS K GGRNG+GAKLCN+FSK F VET R++Q W +NM + E V+E D+T + F PDL RF++D L D+I L RR F++A+ L ++V +Y N + + F+ YV++++++ S F+H T + VA S+ +SFVN INT GG HV+ ++K+V ++ ++ + + K ++P IKN+L IF+N ++ NP FESQ+KE LT+ F S K + GL+E I + ++NM KK P V+++ DIVKL+DA AG T + +CTLILTEGDSAK+ A++GL+VLG++ +GVF L+GK LN N+ + + N++ +++ LG+ ++ +T+E SLRYG+++I+ADQD DGSHIKGLI+NF H WP L+ D F + F TP++KA K + F+S N Y+ W + KW+IKYYKGLGTSTS EA+EYF ++D H +F Y+G+ DD ++M F+R++S +RKEWI +R N D+ KT ISY++F++ +L+ + D Sbjct: 10 LKFCISTSHRTTVVLKNTRSFCNNIPST--SFASEAAAK-YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDAKKTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGITGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRE---SLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADV-EEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWI-----RRSENEITNEDD------GKTEISYQEFVDGQLMQFGMVD 717
BLAST of DNA topoisomerase 2 vs. Ensembl Fly
Match: Top2 (gene:FBgn0284220 transcript:FBtr0332320) HSP 1 Score: 999.964 bits (2584), Expect = 0.000e+0 Identity = 527/1165 (45.24%), Postives = 753/1165 (64.64%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNN---DS----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKY---IRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK--DFPKSL-RKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWI---LQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS----KSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQ-----LLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQAL--------------------------KKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +IE+ YQKK+ +EHIL RPDSY+GS+ + + W++D SQN++++KEI +VP L+KIFDEILVNA+DNK+RD M+ IKI+++ + N +S+ N+G GIPV +H + MY+PT+IFG+LLTSSNY+D +K TGGRNG+GAKLCN+FS SF+VET++ +KQTW NNM + ++ I+ G D+T ITF PDL +FKMD LD DI+AL RRA+D+A++ K VS++ N ++ + +FK Y++L+ N DS + +H N EVA S F Q+SFVN I T GG HV+ V+ L++ L++ ++K+ K I+P Q++N LW+FVN ++ NP F+SQ+KE +T F S+ LS+KF+NN+ G++E + + K D K+ RK + I I KL+DA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R +++ N + ++ +G+ YKKKYLT++ LK+LRYGKVMIM DQD DGSHIKGL++NF H NWPELL+L F E+FITPI+KA K + + FYS ++ W T ++ + IKYYKGLGTSTS EAKEYF+++D+HR F Y GS DD + M F ++ RK W+ + +K+RK L + E ++ K SI+Y DFIN EL+++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QLSGSV+E++ YHH E S+ T+++LAQ++VG+NNINLL P G FGTR+ GGKD ASARYI T +SP+ R I+ DD L + DD Q IEP+WY PIIP VL+NGA G+GTGW T I NYNP +I++NLR ++N + P M PWY+NF G + +Y TG +IL+ LE+ ELP+G+ TQ YKE ++ E L N K I+ +Y + +TDT VRF+I E R++ ++ + L++ +ST M FD+++ ++R+ T ++IL E++K R Y +R+D V ++ A+A + +Q RFI K KL + N L + + DP+K W++ + KKE + E KK + F YLL M + T++K L +KL E E L +++P Sbjct: 9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPS-DRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLE----VLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKEL---GLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVL-EPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFE-RIHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKK--LTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTP 1161
BLAST of DNA topoisomerase 2 vs. Ensembl Fly
Match: Top2 (gene:FBgn0284220 transcript:FBtr0081287) HSP 1 Score: 999.964 bits (2584), Expect = 0.000e+0 Identity = 527/1165 (45.24%), Postives = 753/1165 (64.64%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNN---DS----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKY---IRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK--DFPKSL-RKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWI---LQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS----KSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQ-----LLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQAL--------------------------KKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +IE+ YQKK+ +EHIL RPDSY+GS+ + + W++D SQN++++KEI +VP L+KIFDEILVNA+DNK+RD M+ IKI+++ + N +S+ N+G GIPV +H + MY+PT+IFG+LLTSSNY+D +K TGGRNG+GAKLCN+FS SF+VET++ +KQTW NNM + ++ I+ G D+T ITF PDL +FKMD LD DI+AL RRA+D+A++ K VS++ N ++ + +FK Y++L+ N DS + +H N EVA S F Q+SFVN I T GG HV+ V+ L++ L++ ++K+ K I+P Q++N LW+FVN ++ NP F+SQ+KE +T F S+ LS+KF+NN+ G++E + + K D K+ RK + I I KL+DA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R +++ N + ++ +G+ YKKKYLT++ LK+LRYGKVMIM DQD DGSHIKGL++NF H NWPELL+L F E+FITPI+KA K + + FYS ++ W T ++ + IKYYKGLGTSTS EAKEYF+++D+HR F Y GS DD + M F ++ RK W+ + +K+RK L + E ++ K SI+Y DFIN EL+++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QLSGSV+E++ YHH E S+ T+++LAQ++VG+NNINLL P G FGTR+ GGKD ASARYI T +SP+ R I+ DD L + DD Q IEP+WY PIIP VL+NGA G+GTGW T I NYNP +I++NLR ++N + P M PWY+NF G + +Y TG +IL+ LE+ ELP+G+ TQ YKE ++ E L N K I+ +Y + +TDT VRF+I E R++ ++ + L++ +ST M FD+++ ++R+ T ++IL E++K R Y +R+D V ++ A+A + +Q RFI K KL + N L + + DP+K W++ + KKE + E KK + F YLL M + T++K L +KL E E L +++P Sbjct: 9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPS-DRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLE----VLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKEL---GLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVL-EPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFE-RIHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKK--LTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTP 1161
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2b (DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GENE-041008-136]) HSP 1 Score: 1045.8 bits (2703), Expect = 0.000e+0 Identity = 526/1136 (46.30%), Postives = 755/1136 (66.46%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDP-------VKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEM 3483 ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + +EI +VP L+KIFDEILVNA+DNK+RD M+ IKI ++ + N IS+ N+G GIPVV H E MY+P LIFG+LLTSSNYDD+ +K TGGRNG+GAKLCN+FS F+VET+ + +KQTWT NM + E I+ G DFT +TF+PDL +F M+ LD DI+AL RRA+D+A + + V + N ++P+ SF+ YV+ Y D D + ++ T+N EV +T+S F QISFVN I T GG H++ V+++V L++ + K ++P Q+KN LW+FVN+++ NP F+SQ+KE +T F S+ LS+KF+ +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ LG+ YKK Y ESLKSLRYG++MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T Y W IKYYKGLGTSTS EAKEYF ++++HR F Y+G+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ + +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TC+KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D + L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +LN + P+ M+P Y+NFKG+I+E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML + ++ DY++ +TDT V+F++ + KL E L ++ L S ++ +MVLFD +KRY + EIL EFF+ RL Y+ RKD V + AE+ K NQ RF+ K GKL++ N ++ + +L Q ++SDP+ W +A +E + +ED +F Y+LNMP+ TK+K+E L L + L +AE+ Sbjct: 49 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNL-REISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDNEKKVTGGRNGYGAKLCNIFSLKFTVETACKEYKRSFKQTWTENMGKSNEAKIKYFDGEDFTCVTFQPDLAKFNMEKLDKDIVALLTRRAYDVAGSCRGVKVILNGKKLPVNSFRSYVDFYVKDKLDETGVALKVVNETVNERWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYIVDQIVGKLIEVVKKKNKAGVS-VKPFQVKNHLWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKILGLQYKKSYDDPESLKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSSLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGTIHELGQNQYLVSGEVSVLDKNTIEISELPVRTWTQAYKESVLEPMLQGTDKTPPLISDYKEYHTDTTVKFVVRMTEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQEILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKLSIENKSKRDLIRMLVQRGYESDPVAAWNKA--QEKSLEEEDGGGNDSDSSVDSGSFSGPNFNYILNMPLWCLTKEKVEEL--LKQRDLKKAEL 1172
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453]) HSP 1 Score: 1008.82 bits (2607), Expect = 0.000e+0 Identity = 522/1137 (45.91%), Postives = 737/1137 (64.82%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDSQF--IHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHLKLD-LKEIR-LNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + ++I +VP L+KIFDEILVNA+DNK+RD M+ IK+N++ + N IS+ N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + +KQTW +NM + E I+ G D+T ITF+PDL +FKM LD D +AL RRA+DIA + K V + N ++PI +F+ YV+LY D S +H +N EV +TLS F Q+SFVN I T GG H + +++V L+ E + K++ ++P Q+KN +W+FVN ++ NP F+SQ+KE +T F S LSDKFV CG++E I Q+ +N K S K I + KLDDA AG K S CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ LG+ YKK Y ESLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+KA Q I FYS + W + W+IKYYKGLGTSTS EAKEYF ++ +HR F YSG DD + + F ++ +RKEW+ ++ R+ + N+ EE ++ + S+SY DFINKEL+++SN DN R+IP ++DGLKP QRK+++ C KRN ++VKV QL+GSV+E++ YHH E S+ T++ LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP DDN L+ YDDN +EP WY PIIP VL NG G+GTGW + IPNY+ +II N+ +LN + P+ M+P Y+ FKG+I+E + +Y G+ I++S T+E+ ELP+ TQ YKE ++ ML ++ +++ DY++ +TDT VRF++ + + L+E L ++ L + ++ +MVLFD +K+Y + +IL EFF+ R+ Y RKD V + AE+ K NQ RFI K G L + N + E +L+Q +DSDP+K W+ A +KE ED +K + S D+ YLL+MP+ TK+K + L +K+ E L ++P Sbjct: 28 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEDTG-MNCRDITFVPGLYKIFDEILVNAADNKQRDKTMNCIKVNIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETACRESKRCFKQTWFDNMGRAGESKIKPFDGDDYTCITFQPDLAKFKMQALDKDTVALLTRRAYDIAGSTKGVRVLLNGKRLPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEK-GFQQVSFVNSIATTKGGRHTDYVADQIVSKLI---EVVKKKNKAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKFKAQAQLNKKC----SAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYSDPESLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKQEISFYSIPEFTEWKEKQSSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLAFSKKMIEERKEWLTSFMINRRQRREHNLPEEYLYGQETKSLSYHDFINKELVLFSNSDNERSIPCMVDGLKPGQRKVVFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKENVLEVMLNGTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYDSDPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAP 1155
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453]) HSP 1 Score: 294.664 bits (753), Expect = 2.175e-84 Identity = 165/394 (41.88%), Postives = 247/394 (62.69%), Query Frame = 1 Query: 2344 SIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHLKLD-LKEIR-LNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 S+ T++ LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP DDN L+ YDDN +EP WY PIIP VL NG G+GTGW + IPNY+ +II N+ +LN + P+ M+P Y+ FKG+I+E + +Y G+ I++S T+E+ ELP+ TQ YKE ++ ML ++ +++ DY++ +TDT VRF++ + + L+E L ++ L + ++ +MVLFD +K+Y + +IL EFF+ R+ Y RKD V + AE+ K NQ RFI K G L + N + E +L+Q +DSDP+K W+ A +KE ED +K + S D+ YLL+MP+ TK+K + L +K+ E L ++P Sbjct: 2 SLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKENVLEVMLNGTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYDSDPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAP 395
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Match: top2b (DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GENE-041008-136]) HSP 1 Score: 107.071 bits (266), Expect = 1.894e-26 Identity = 49/96 (51.04%), Postives = 70/96 (72.92%), Query Frame = 1 Query: 169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSG 456 +E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + +EI +VP L+KIFDEILVNA+DNK+RD M+ IKI ++ + N IS+ N+G G Sbjct: 45 VERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNL-REISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKG 139
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457]) HSP 1 Score: 1043.49 bits (2697), Expect = 0.000e+0 Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ +S W++D+ + ++I YVP L+KIFDEILVNA+DNK+RD M+ IKI+++ D N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTWTNNM + TEP I+ G D+T ITF+PDL +F+M+ LD D +AL RRA+DIA + K V + N ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+FVN ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T + W+IKYYKGLGTSTS EAKEYF ++D+HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW +PNY+ +I+ N++ +L+ P ++P Y+NFKG+I E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML ++ S++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ + + AEA + NQ RF+ K GK+++ N + + +L Q F+SDP+K W++A +K D ED DF Y+LNM + S +K+K++ L K E L R+SP Sbjct: 97 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1228
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457]) HSP 1 Score: 1043.11 bits (2696), Expect = 0.000e+0 Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ +S W++D+ + ++I YVP L+KIFDEILVNA+DNK+RD M+ IKI+++ D N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTWTNNM + TEP I+ G D+T ITF+PDL +F+M+ LD D +AL RRA+DIA + K V + N ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+FVN ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T + W+IKYYKGLGTSTS EAKEYF ++D+HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW +PNY+ +I+ N++ +L+ P ++P Y+NFKG+I E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML ++ S++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ + + AEA + NQ RF+ K GK+++ N + + +L Q F+SDP+K W++A +K D ED DF Y+LNM + S +K+K++ L K E L R+SP Sbjct: 47 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1178
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457]) HSP 1 Score: 1042.72 bits (2695), Expect = 0.000e+0 Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ +S W++D+ + ++I YVP L+KIFDEILVNA+DNK+RD M+ IKI+++ D N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTWTNNM + TEP I+ G D+T ITF+PDL +F+M+ LD D +AL RRA+DIA + K V + N ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+FVN ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T + W+IKYYKGLGTSTS EAKEYF ++D+HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW +PNY+ +I+ N++ +L+ P ++P Y+NFKG+I E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML ++ S++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ + + AEA + NQ RF+ K GK+++ N + + +L Q F+SDP+K W++A +K D ED DF Y+LNM + S +K+K++ L K E L R+SP Sbjct: 51 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1182
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457]) HSP 1 Score: 1041.95 bits (2693), Expect = 0.000e+0 Identity = 528/1140 (46.32%), Postives = 752/1140 (65.96%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ +S W++D+ + ++I YVP L+KIFDEILVNA+DNK+RD M+ IKI+++ D N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTWTNNM + TEP I+ G D+T ITF+PDL +F+M+ LD D +AL RRA+DIA + K V + N ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+FVN ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T + W+IKYYKGLGTSTS EAKEYF ++D+HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW +PNY+ +I+ N++ +L+ P ++P Y+NFKG+I E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML ++ S++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ + + AEA + NQ RF+ K GK+++ N + + +L Q F+SDP+K W++A +K D ED DF Y+LNM + S +K+K++ L K E L R+SP Sbjct: 47 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1178
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Match: TOP2B (DNA topoisomerase II beta [Source:NCBI gene;Acc:779457]) HSP 1 Score: 1036.17 bits (2678), Expect = 0.000e+0 Identity = 529/1142 (46.32%), Postives = 753/1142 (65.94%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK-----EHRIFD--EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ +S W++D+ + ++I YVP L+KIFDEILVNA+DNK+RD M+ IKI+++ D N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTWTNNM + TEP I+ G D+T ITF+PDL +F+M+ LD D +AL RRA+DIA + K V + N ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+FVN ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S +CTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T + W+IKYYKGLGTSTS EAKEYF ++D+HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E ++ T+++LAQ++VGSNN++LL P+G FGTR++GGKD AS RYI T LSP+ R ++P+ DDN L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW +PNY+ +I+ N++ +L+ P ++P Y+NFKG+I E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML ++ S++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ + + AEA + NQ RF+ K GK+++ N + + +L Q F+SDP+K W++A +K E + D ED DF Y+LNM + S +K+K++ L K E L R+SP Sbjct: 2 SVERVYQKKTQLEHILLRPDTYIGSVETVTQSMWVYDEDVG-MNCRDITYVPGLYKIFDEILVNAADNKQRDKNMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFDGDDYTCITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVKDRLDETGVALKVIHEVANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNKAGVS-VKPFQVKNHVWVFVNCLIENPTFDSQTKENMTLQPKGFGSKCQLSEKFSKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDNESLKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHSFLEEFITPIVKATKNKQELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEVTLMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDDNLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGLDPYPLLPSYKNFKGTIQELGQNQYAMSGEIYVLDRNTIEITELPVRTWTQVYKEQVLEPMLNGTEKTPSLISDYKEYHTDTTVKFVVKMTEEKLAQAEAA-GLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYTLRKEWLIGMLGAEAARLNNQARFVLEKIQGKISIENKTKRDLIQMLVQKGFESDPVKAWKEAQEKVGATEEDDLQDPNEDNSSDSGTGSGPDFNYILNMSLWSLSKEKVDELVRQRDIKSKELNDLKRKSP 1135
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Match: Top2a (topoisomerase (DNA) II alpha [Source:MGI Symbol;Acc:MGI:98790]) HSP 1 Score: 1038.48 bits (2684), Expect = 0.000e+0 Identity = 528/1140 (46.32%), Postives = 753/1140 (66.05%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK------EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +IE+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+S +KQTW +NM + + ++ G D+T ITF+PDL++FKM +LD DI+AL RRA+DIA + K+V ++ N +P+ F+ YV+LY N + IH +N EV +T+S F QISFVN I T GG HV+ +++V LV ++K+ K ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T F S LS+KF+ I CG++E I + + K S K I I KLDDA AG++ S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+K K+ Q I FYS ++ W +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F ++Q RKEW+ +++ R+ + E+ ++ ++ + ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP DD+ L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ +++ N+R LL+ + P+ M+P Y+NFKG+I E +Y G+ IL+S T+E+ ELPI TQ YKE ++ ML ++ S++ DY + +TDT V+F+I + KL E R+ L ++ L S ++ +MVLFD +K+Y T ++IL +FF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q +DSDP+K W++A +K E E F YLL+MP+ TK+K + L K E L ++SP Sbjct: 28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMS-ERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAE-RVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSP 1160
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Match: Top2b (topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791]) HSP 1 Score: 1029.62 bits (2661), Expect = 0.000e+0 Identity = 533/1177 (45.28%), Postives = 760/1177 (64.57%), Query Frame = 1 Query: 55 LASSRYLLKYFNNISHSLSIRCKYSNLPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFD-----EDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 LA S L + NN + + N +TK L ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ + +E+ +VP L+KIFDEILVNA+DNK+RD M+ IK++++ + N ISI N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNM + +E I+ G D+T ITF+PDL++FKM+ LD DI+AL RRA+D+A + K V + FN ++P+ F+ YV+LY D D + IH N +V +TLS F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+F+N ++ NP F+SQ+KE +T P F S+ LS+KF +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+KA K+ Q + FYS + W K + W+IKYYKGLGTST+ EAKEYF ++++HR F Y+G EDD + + F +++ RKEW+ +++ R+ + E+ ++ ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNNINLL P+G FGTR++GGKD AS RYI T LS + R +FPA DDN L+ YDDNQ +EP WY PIIP VLINGA G+GTGW +PNY+ +I+ N+R +L P M+P Y+NFKG+I E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TDT V+F++ + KL E L ++ L + ++ +MVLFD +K+Y T +IL EFF RL Y RK+ V + AE+ K NQ RFI K GK+ + N ++ + +L Q ++SDP+K W++A +K D +D DF Y+LNM + S TK+K+E L +K E L R+SP Sbjct: 6 LAGSDGALTWVNNATKKEELETANKN--DSTKKL---SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEK-GFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGVS-VKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKC----SSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSP 1169
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Match: Top2b (topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791]) HSP 1 Score: 108.612 bits (270), Expect = 7.439e-26 Identity = 56/160 (35.00%), Postives = 96/160 (60.00%), Query Frame = 1 Query: 2605 INGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSE 3066 INGA G+GTGW +PNY+ +I+ N+R +L P M+P Y+NFKG+I E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TDT V+F++ + KL E L ++ L + ++ +M +E S+ Sbjct: 2 INGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEA-AGLHKVFKLQTTLTCNSMAAEEEDSQ 160
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|O46374|TOP2A_PIG (DNA topoisomerase 2-alpha OS=Sus scrofa OX=9823 GN=TOP2A PE=2 SV=1) HSP 1 Score: 1046.96 bits (2706), Expect = 0.000e+0 Identity = 531/1142 (46.50%), Postives = 758/1142 (66.37%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +IE+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+S +KQTW +NM + E ++ G D+T ITF PDL++FKM +LD DI+AL RRA+DIA + K+V ++ N ++P+ F+ YV+LY N + IH +N+ EV +T+S F QISFVN I T GG HV+ +++V LV ++K+ K ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T F S LS+KF+ I CG++E I + + K S K N I I KLDDA AG + S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+K K+ Q + FYS ++ W +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F ++Q RKEW+ +++ R+ + E+ ++ + T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP DD+ L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ +++ N+RLL++ + P+ M+P Y+NFKG+I E +Y +G+ ILNS T+E+ ELPI TQ YKE ++ ML ++ ++ DY + +TDT V+F++ + KL E R+ L ++ L + ++ +MVLFD +K+Y T ++IL +FF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q +DSDP+K W++A +K + + + D F YLL+MP+ TK+K + L L K E E L R+SP Sbjct: 29 SIERIYQKKTQLEHILLRPDTYIGSVESVTQQMWVYDEDIG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFHPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDLYLKDKVDETGNPLKIIHEQVNHRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVAKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRLLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKEADKSDSVADSGPTFNYLLDMPLWYLTKEKKDELCKLRNEKEQELETLKRKSP 1163
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|O42130|TOP2A_CHICK (DNA topoisomerase 2-alpha OS=Gallus gallus OX=9031 GN=TOP2A PE=2 SV=2) HSP 1 Score: 1043.49 bits (2697), Expect = 0.000e+0 Identity = 525/1146 (45.81%), Postives = 760/1146 (66.32%), Query Frame = 1 Query: 133 LPTTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 LP + ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + +++ +VP L+KIFDEILVNA+DNK+RD MS IK+ ++ + N IS+ N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ +KQTWT+NM + E ++ G D+T +TF+PDL++FKM LD DI+AL RRA+DIA + K+V ++ N ++P+ F+ YV+LY N + IH +N+ EV +TLS F Q+SFVN I T GG HV+ +++V L+ + K + ++P Q+KN +WIFVNS++ NP F+SQ+KE +T F S LS+KF+ + CG++E I Q+ +N K S K I + KLDDA AG+K S +CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y +ESLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+K K+ + IPFYS ++ W +T +Y+ W+IKYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F +++ +RKEW+ +++ R+ + E+ ++ K+ ++Y DFINKEL+++SN DN R+IPS++DGLKP QRK+++TC KRN ++VK QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP DDN L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ + + N+R LL+ K P+ M+P Y+NFKG+I+E +Y +G+ IL+S T+E+ ELP+ TQ YKE ++ ML ++ ++ DY++ +TDT V+F++ + KL E + L ++ L + ++ +MVLFD +K+Y +P +IL EFF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q ++SDP+K W++ L+ + ++ ++ DF YLLNMP+ TK+K + L +K E E L +SP Sbjct: 19 LPKADGAQKRLSVERIYQKKTQLEHILLRPDTYIGSVETVTQQMWVFDEDVG-LNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVTIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACREYKKLFKQTWTDNMGKAGEMTLKHFDGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIAGSTKDVKVFLNGKRLPVKGFRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEK-GFQQVSFVNSIATTKGGRHVDYVADQIVTKLIDVVKKKNK-NGVGVKPFQVKNHMWIFVNSLIENPTFDSQTKENMTLQAKSFGSTCKLSEKFIKGAVGCGIVESILNWVKFKAQTQLNKKC----SAVKHTKIKGVPKLDDANDAGSKNSIDCTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKMLNVREASHKQIMENAEINNIIKIVGLQYKKNYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSKNKEEIPFYSIPEFEEWKSSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPEDDAAITLAFSKKKVEERKEWLTNFMEDRRQRNVHGLPEDYLYGKDTNYLTYNDFINKELVLFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKGAQLAGSVAEMSSYHHGEASLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDNVLRFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRCLLDGKEPLPMLPSYKNFKGTIDELGPNQYVISGEVSILDSTTIEITELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYKEYHTDTTVKFVVKMSEEKLAEAEA-VGLHKVFKLQTNLTCNSMVLFDHVGFLKKYESPQDILKEFFELRLRYYGLRKEWLIGMLGAESAKLNNQARFILEKIDGKIVIENKPKKELIQVLIQRGYESDPVKAWKE-LQNKEEEEGDESGEESAAATGPDFNYLLNMPLWYLTKEKKDELCKQRDNKDKELEDLKHKSP 1155
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|P11388|TOP2A_HUMAN (DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3) HSP 1 Score: 1041.57 bits (2692), Expect = 0.000e+0 Identity = 528/1142 (46.23%), Postives = 758/1142 (66.37%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+S +KQTW +NM + E ++ G D+T ITF+PDL++FKM +LD DI+AL RRA+DIA + K+V ++ N ++P+ F+ YV++Y N + IH +N+ EV +T+S F QISFVN I T GG HV+ +++V LV ++K+ K ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T P F S LS+KF+ I CG++E I + + K S K N I I KLDDA AG + S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+K K+ Q + FYS ++ W +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F ++Q RKEW+ +++ R+ + E+ ++ + T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LS + R +FP DD+ L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ +I+ N+R L++ + P+ M+P Y+NFKG+I E +Y +G+ ILNS T+E+ ELP+ TQ YKE ++ ML ++ ++ DY + +TDT V+F++ + KL E R+ L ++ L + ++ +MVLFD +K+Y T ++IL +FF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q +DSDP+K W++A +K + + E D F YLL+MP+ TK+K + L L K E + L R+SP Sbjct: 29 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVTKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSP 1163
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|Q01320|TOP2A_MOUSE (DNA topoisomerase 2-alpha OS=Mus musculus OX=10090 GN=Top2a PE=1 SV=2) HSP 1 Score: 1038.48 bits (2684), Expect = 0.000e+0 Identity = 528/1140 (46.32%), Postives = 753/1140 (66.05%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK------EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +IE+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+S +KQTW +NM + + ++ G D+T ITF+PDL++FKM +LD DI+AL RRA+DIA + K+V ++ N +P+ F+ YV+LY N + IH +N EV +T+S F QISFVN I T GG HV+ +++V LV ++K+ K ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T F S LS+KF+ I CG++E I + + K S K I I KLDDA AG++ S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+K K+ Q I FYS ++ W +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F ++Q RKEW+ +++ R+ + E+ ++ ++ + ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP DD+ L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ +++ N+R LL+ + P+ M+P Y+NFKG+I E +Y G+ IL+S T+E+ ELPI TQ YKE ++ ML ++ S++ DY + +TDT V+F+I + KL E R+ L ++ L S ++ +MVLFD +K+Y T ++IL +FF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q +DSDP+K W++A +K E E F YLL+MP+ TK+K + L K E L ++SP Sbjct: 28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMS-ERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAE-RVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSP 1160
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Match: sp|P41515|TOP2A_CRIGR (DNA topoisomerase 2-alpha OS=Cricetulus griseus OX=10029 GN=TOP2A PE=1 SV=1) HSP 1 Score: 1038.1 bits (2683), Expect = 0.000e+0 Identity = 527/1138 (46.31%), Postives = 756/1138 (66.43%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDF----PKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK----EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +IE+ YQKKT +EHIL RPD+Y+GS+ + W++D+ I +E+ +VP L+KIFDEILVNA+DNK+RD +MS I++ ++ + N ISI N+G GIPVV H E MY+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+S+ +KQTW +NM + + ++ G D+T ITF+PDL++FKM +LD DI+AL RRA+DIA + K+V ++ N ++P+ F+ YV++Y N + +H +N EV +T+S F QISFVN I T GG HV+ +++V LV ++K+ K ++ +Q+KN +WIFVN+++ NP F+SQ+KE +T F S LS+KF+ I CG++E I + + K S K N I I KLDDA AG++ S ECTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ++SLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ F E+FITPI+K K+ Q + FYS ++ W +TP++ KW++KYYKGLGTSTS EAKEYF ++ +HR F YSG EDD + + F ++Q RKEW+ +++ R+ + E+ ++ + T ++Y DFINKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GSV+E+++YHH E S+ T+I+LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP DD+ L+ YDDNQ +EP WY PIIP VLINGA G+GTGW IPN++ +++ N+R LL+ + P+ M+P Y+NFKG+I E +Y G+ ILNS T+E+ ELPI TQ YKE ++ ML ++ ++ DY + +TDT V+F+I + KL E R+ L ++ L + ++ +MVLFD +K+Y T ++IL +FF+ RL Y RK+ + + AE+ K NQ RFI K GK+ + N + E +L Q +DSDP+K W++A +K E ++ + E F YLL+MP+ TK+K + L K E L +SP Sbjct: 28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVETASKEYKKMFKQTWMDNMGRAGDMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNALKVVHEQVNPRWEVCLTMSEK-GFQQISFVNSIATSKGGRHVDYVADQIVSKLVD----VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQELAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMTEEKLAEAE-RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILKDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNENSDSVAESGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKNKSP 1158
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A5K3ERS3 (DNA topoisomerase 2 OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 1069.69 bits (2765), Expect = 0.000e+0 Identity = 528/1153 (45.79%), Postives = 775/1153 (67.22%), Query Frame = 1 Query: 136 PTTTKSLILE-NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY------DNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLE------RIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSI---VRDYEDRNTDTEVRFIIHLKLD-LKEIR-LNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK---------------EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLN 3489 P TKS ++E+ YQKKT +EHIL RPD+Y+GS+++S W+FDK + +++KEI Y P L+KI+DEILVNA+DNK RD M+ I+I++ +EN + I N+G+GIPVV H ENMY+P+LIFG+LLTSSNYDD+ +K TGGRNG+GAKLCN+FSK F VETSS+ +KQTW +NMT+ +EP I+ G DFT I+F+PDL RF M LD D +ALF RRA+D+A++ + V ++ N +IPI SFK YV+LY D + ++ ++N E+AV S++ F Q+SFVN I T+ GG HV+ +++V LV + + I+ QI++ +W+F+N ++ NP F+SQ+KE+++ F S LS+KF+N + G++E R ++ M K KS K + I KLDDA AGTK S CTLILTEGDSAKS A++GL V+G+D +GVF L+GK LN R R+++ N + +++ LG+ YK KY T+ESL +LRYGK+MIM DQD DGSHIKGLI++F HHNWP+LL +F EQFITPI+K FK Q I FYS ++ W KATP++ WR+KYYKGLGTS+S EAKEYF ++ +HR F YSG EDD + + F + + +RK+W+ W+++++ + + E+ ++ +++Y DFI+KEL+++SN DN R+IPS++DGLKP QRK+++TCLKRN +K++KV QL G+VSE+++YHH E S+ T++ LAQD+VGSNN+NLL+P G FGTR+ GGKD+ASARYI T LSP+ R IF DD L ++DNQ IEP WY P+IP VLINGA G+GTGW T +PNY+ ++I N+R +L+ P+ M+P YR ++G I E + +Y G+ +L+ +T+E+ ELP+ + TQ YKE ++ ML ++ + + DY++ +TD VRF++ + + L+E + L + L+ ++T +MVLFD +KRY++ EIL +F+K RL YEKRK + +EA++ ENQ RF+ K A K+ + N ++ E LL++ +D DP++ W++++ K E + DE+ V + + D+ Y+L MP+ S +K++ ++L L + +AE+ N Sbjct: 17 PVQTKSPRKRLSVERIYQKKTQLEHILIRPDTYIGSVSRSATMMWVFDKEKQSMVQKEITYTPGLYKIYDEILVNAADNKIRDPTMNCIRIDIKPEENLVRIWNNGAGIPVVHHKVENMYVPSLIFGHLLTSSNYDDTEQKVTGGRNGYGAKLCNIFSKRFVVETSSKDNKKSFKQTWVDNMTKTSEPQIKVNSGEDFTCISFQPDLNRFGMTELDADTVALFERRAYDVAASTRGVKVFLNGQRIPIKSFKDYVDLYLKDKGEDGDAVPVVYESVNPRWEIAVAPSST-GFQQVSFVNSIATIKGGKHVDYIADQVVGKLVDIVKKKSGKSGVAIKNFQIRSHMWVFINCLIVNPTFDSQTKEFMSLEAKNFGSVCQLSEKFINQVSKSGIVESILSWVRFKAQEKMDKQCHKS--KHAKLKGIPKLDDANDAGTKNSQHCTLILTEGDSAKSLAVAGLGVVGRDRYGVFPLRGKLLNVREAPTRQIMENAEINNLIKILGLQYKNKYETQESLANLRYGKIMIMTDQDQDGSHIKGLIISFIHHNWPKLLHHNFLEQFITPIVKIFKGKQEIAFYSIPEFEEWQKATPNWHTWRVKYYKGLGTSSSKEAKEYFSDMTRHRIRFRYSGPEDDSGIVLAFNKNKINERKQWLTSWMEEKRRRTELGLPEDYLYGAGTHTVTYHDFIHKELVLFSNMDNERSIPSLVDGLKPGQRKVMFTCLKRNQVKEIKVAQLCGAVSEMSSYHHGEMSLMGTIVGLAQDFVGSNNLNLLMPYGQFGTRLSGGKDSASARYIFTALSPLTRKIFHENDDAILHYLFEDNQKIEPSWYIPVIPMVLINGAEGIGTGWSTKVPNYDTAEVIANIRRMLDGVDPLPMLPSYRGYRGKIVEVGENRYILFGEIAVLDDQTVEITELPVRVWTQSYKETVLEPMLNGTEKVPVSITDYKEYHTDVTVRFVVQMPREKLREAESVGLHKFFKLAVSLTTNSMVLFDHAGCLKRYTSAQEILKDFYKLRLEWYEKRKAFMEGMLSSEARRLENQARFVMEKIADKVTIENKSKKELLRLLRERHYDPDPVRAWKESIDKLAAIEDAAAARRQAGEPEVGDEEDVDQA--SGTADYNYILGMPLWSLSKERKDDL--LAQRDKKQAELTN 1162
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A5C6NGH8 (DNA topoisomerase 2 OS=Takifugu flavidus OX=433684 GN=D4764_21G0008480 PE=3 SV=1) HSP 1 Score: 1069.3 bits (2764), Expect = 0.000e+0 Identity = 537/1140 (47.11%), Postives = 762/1140 (66.84%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKK---EHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + ++EI YVP L+KIFDEILVNA+DNK+RD M+ IKI+++ + N ISI N+G GIPVV H E MY+P LIFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNMT+ +P ++ G DFT +TF+PDL++FKM+ LD DIIAL RRA+D+A + K V + N ++P+ F+ YV+LY D D + ++ T+N EV +TLS F QISFVN I T GG H++ V+++V L+ E + K++ ++P Q+KN +W+FVN+++ NP F+SQ+KE +T F S+ LSDKF+ +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS ++ W K T +Y W IKYYKGLGTSTS EAKEYF +++HR +F YSG+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FP D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+ +I+ N+ +LN + P+QM+P Y+NFKG I+E Q +Y +G+ +++ T+EV ELP+ TQ YKE ++ ML S +++ DY++ +TDT V+F++ + KL E + L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL Y+ RKD V + AEA K NQ RF+ K GK+++ N ++ E +L Q F+SDP+ W +A +K E + D +F Y+LNMP+ TK+++E L K E L R+SP Sbjct: 39 SVERVYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEDVG-MNQREISYVPGLYKIFDEILVNAADNKQRDKNMTAIKISIDPESNTISIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTADPKVKFFDGDDFTCVTFQPDLSKFKMEKLDKDIIALLTRRAYDVAGSCKGVKVTLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVNETVNERWEVCLTLSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKLI---EVVKKKNKAGVTVKPFQVKNHIWVFVNALIENPSFDSQTKENMTLQTKSFGSKCPLSDKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKATKNKQEMAFYSIPEFEEWKKHTENYKSWHIKYYKGLGTSTSKEAKEYFAEMEKHRITFRYSGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGSQARHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNLNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPVVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDVREIVNNIYRMLNHQDPLQMLPSYKNFKGVIHELGQNQYLVSGEVSVIDKNTIEVTELPVRTWTQAYKESVLEPMLQGSDKTPALINDYKEYHTDTTVKFLVRMSEEKLAQAE-SVGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQDILKEFFELRLHYYKLRKDWLVGSLGAEAAKLSNQARFVLEKIEGKVSIENKSKRELIRMLVQKGFESDPVAAWTKAQEKALEEDGGNESDTSLDSGSTSGPNFNYILNMPLWCLTKERVEELLKQRDLKRGELNELQRKSP 1168
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A3Q0RLH9 (DNA topoisomerase 2 OS=Amphilophus citrinellus OX=61819 PE=3 SV=1) HSP 1 Score: 1068.14 bits (2761), Expect = 0.000e+0 Identity = 534/1139 (46.88%), Postives = 761/1139 (66.81%), Query Frame = 1 Query: 169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + + ++EI YVP L+KIFDEILVNA+DNK+RD M+ IKI ++ + N ISI N+G GIPVV H E MY+P LIFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNMT+ +EP I+ G DFT +TF+PDL +FKM+NLD DI+AL RRA+D+A + K V + N ++P+ F+ YV+LY D D + +H +N+ EV +T+S F QISFVN I T GG H++ V+++V L++ + K ++P Q+KN +W+FVN+++ NP F+SQ+KE +T F S+ LLSDKFV +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS + W K T +Y W IKYYKGLGTSTS EAKEYF ++++HR +F Y+G+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ + +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +LN + P+ M+P Y+NFKG I+E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TD V+F++ + KL E L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL + RKD + + AEA K NQ RF+ K GK+ + N ++ E +L Q F+SDP+ W +A +K +D + +S +F Y+LNMP+ TK+K++ L K E L R+SP Sbjct: 48 VERVYQKKTQLEHILLRPDTYIGSVEPITQQMWVFDE-EIGMNQREITYVPGLYKIFDEILVNAADNKQRDKNMTAIKITIDPESNIISIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTSEPKIKFFDGDDFTCVTFQPDLAKFKMENLDKDIVALLTRRAYDVAGSCKGVKVSLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVHEAVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKLIEVVKKKNKAGVS-VKPFQVKNHIWVFVNALIENPSFDSQTKENMTLQTKSFGSKCLLSDKFVRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKATKNKQELSFYSIPEFDEWKKHTENYKSWHIKYYKGLGTSTSKEAKEYFADMEKHRITFRYTGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTHARHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNIYRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVVDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALISDYKEYHTDATVKFVVRMSEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEASKLSNQARFVLEKIEGKIVIENKSKRELVRMLVQKGFESDPVAAWAKAQEKSQEEVSQDGNESDSSLDSGSTSGPNFNYILNMPLWCLTKEKVDELLKQRDQKRGELNDLQRKSP 1178
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A2I4CPW4 (DNA topoisomerase 2-beta OS=Austrofundulus limnaeus OX=52670 GN=top2b PE=4 SV=1) HSP 1 Score: 1067.76 bits (2760), Expect = 0.000e+0 Identity = 534/1144 (46.68%), Postives = 761/1144 (66.52%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYD--------FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504 ++E+ YQKKT +EHIL RPDSY+GS+ + W+FD+ + ++EI YVP L+KIFDEILVNA+DNK+RD MS IK+ ++ + N I+I N+G GIPVV H E MY+P LIFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNMT+ T+ ++ G DFT +TF+PDL++FKM+ LD D++AL RR +D+A + K V + N ++P+ F+ YV+LY D D + +H T+N EV +T+S F QISFVN I T GG HV+ V+++V L++ + K ++P Q+KN +W+FVNS++ NP F+SQ+KE +T F S+ +LSDKFV +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F EQFITP++KA K+ Q + FYS ++ W K T ++ W IKYYKGLGTSTS EAKEYF ++++HR +F Y+G+EDD + + F +++ RKEW+ +++ R+ + E+ ++ +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ LLN + P+ M+P Y+NFKG I+E +Y +G+ +L+ T+E+ +LP+ TQ YKE ++ ML+ + +++ DY++ +TDT V+F++ + KL E + L ++ L S ++ +MVLFD +KRY + EIL EFF RL Y+ RKD + + +EA K NQ RF+ K GK+ + N ++ E +L Q F+SDP+ W +A +K +ED + S D F Y+LNMP+ TK+K+++L K E L R+SP Sbjct: 34 SVERVYQKKTQLEHILLRPDSYIGSVEPLTQQMWVFDEDVG-MNQREITYVPGLYKIFDEILVNAADNKQRDKTMSAIKVTIDPESNTITIWNNGKGIPVVEHKVEKMYVPALIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTTDSKVKFFDGDDFTCVTFQPDLSKFKMEKLDKDVVALLTRRVYDVAGSCKGVKVSLNGKKLPVHGFRSYVDLYVKDKLDETGVPLKVVHETVNERWEVCLTMSEK-GFQQISFVNSIATTKGGRHVDYVVDQIVTKLIEVVKKKNKAGVS-VKPFQVKNHIWVFVNSLIENPSFDSQTKENMTLQMKSFGSKCVLSDKFVRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEQFITPLVKATKNKQELSFYSLPEFEEWKKQTENFKTWHIKYYKGLGTSTSKEAKEYFADMERHRITFKYNGAEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTQAKHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRLLNHQDPLPMLPNYKNFKGVIHELGHNQYLVSGEVSVLDKNTVEITDLPVRTWTQAYKESVLEPMLLGTDKTPALINDYKEYHTDTTVKFVVRMSEEKLAQAEA-VGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQEILKEFFDLRLHYYKLRKDWLLGSLGSEAAKLSNQARFVLEKIEGKITIENKSKRELIRMLVQKGFESDPVAAWSKAQEKTQ---EEDYPDGNESDSSVDSGSTSGPNFNYILNMPLWCLTKEKVDDLLKQRDQKRCELNDLQRKSPE 1166
BLAST of DNA topoisomerase 2 vs. TrEMBL
Match: A0A3Q0RFV2 (DNA topoisomerase 2 OS=Amphilophus citrinellus OX=61819 PE=3 SV=1) HSP 1 Score: 1067.37 bits (2759), Expect = 0.000e+0 Identity = 534/1139 (46.88%), Postives = 761/1139 (66.81%), Query Frame = 1 Query: 169 IEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + + ++EI YVP L+KIFDEILVNA+DNK+RD M+ IKI ++ + N ISI N+G GIPVV H E MY+P LIFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNMT+ +EP I+ G DFT +TF+PDL +FKM+NLD DI+AL RRA+D+A + K V + N ++P+ F+ YV+LY D D + +H +N+ EV +T+S F QISFVN I T GG H++ V+++V L++ + K ++P Q+KN +W+FVN+++ NP F+SQ+KE +T F S+ LLSDKFV +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q + FYS + W K T +Y W IKYYKGLGTSTS EAKEYF ++++HR +F Y+G+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ + +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +LN + P+ M+P Y+NFKG I+E Q +Y +G+ +++ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TD V+F++ + KL E L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL + RKD + + AEA K NQ RF+ K GK+ + N ++ E +L Q F+SDP+ W +A +K +D + +S +F Y+LNMP+ TK+K++ L K E L R+SP Sbjct: 48 VERVYQKKTQLEHILLRPDTYIGSVEPITQQMWVFDE-EIGMNQREITYVPGLYKIFDEILVNAADNKQRDKNMTAIKITIDPESNIISIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTSEPKIKFFDGDDFTCVTFQPDLAKFKMENLDKDIVALLTRRAYDVAGSCKGVKVSLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVHEAVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKLIEVVKKKNKAGVS-VKPFQVKNHIWVFVNALIENPSFDSQTKENMTLQTKSFGSKCLLSDKFVRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKATKNKQELSFYSIPEFDEWKKHTENYKSWHIKYYKGLGTSTSKEAKEYFADMEKHRITFRYTGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTHARHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNIYRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVVDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALISDYKEYHTDATVKFVVRMSEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEASKLSNQARFVLEKIEGKIVIENKSKRELVRMLVQKGFESDPVAAWAKAQEKSQEEVSQDGNESDSSLDSGSTSGPNFNYILNMPLWCLTKEKVDELLKQRDQKRGELNDLQRKSP 1178
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Match: top2b (DNA topoisomerase II beta [Source:ZFIN;Acc:ZDB-GENE-041008-136]) HSP 1 Score: 1064.29 bits (2751), Expect = 0.000e+0 Identity = 533/1134 (47.00%), Postives = 764/1134 (67.37%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK---SIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIW----EQALKKEHRIFDEDPVKKGIFEESY-DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEM 3483 ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + +EI YVP L+KIFDEILVNA+DNK+RD MS IKI ++ + N +SI N+G GIPVV H E MY+P LIFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNMT+ ++P I+ G DFT +TF+PDL++FKM+ LD DI+AL RRA+D+A + K V ++ N ++P+ F+ YV+LY D D + ++ ++N EV +T+S F QISFVN I T GG H++ V+++V L++ + K ++P Q+KN +W+FVN+++ NP F+SQ+KE +T F S+ LS+KF+ +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESLKSLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F E+FITPI+KA K+ Q IPFYS + W K T +Y W IKYYKGLGTSTS EAKEYF ++++HR F Y G+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TC+KRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNN+N+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +L+ + P+ M+P Y+NFKG I+E Q +Y +G+ +L+ T+E+ ELPI TQ YKE ++ ML ++ +++ DY++ +TDT V+F++ + KL E L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL Y+ RKD V + AE+ K NQ RF+ K GK+++ N ++ E +L Q ++SDP+ W E+AL++E R +E S +F Y+LNMP+ TK+K++ L L + L +AE+ Sbjct: 49 SVERVYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNL-REITYVPGLYKIFDEILVNAADNKQRDKNMSSIKITIDPESNTVSIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWQNNMTKTSDPKIKYFDGDDFTCVTFQPDLSKFKMEKLDKDIVALLTRRAYDVAGSCKGVKVFLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVVNESVNERWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVSKLIEVVKKKNKAGVT-VKPFQVKNHIWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEIPFYSIPEFDEWKKQTENYKTWHIKYYKGLGTSTSKEAKEYFADMERHRIMFKYGGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTATRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCMKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLDHQDPLPMLPSYKNFKGVIHELGQNQYVVSGEISVLDKNTIEITELPIRTWTQAYKESVLEPMLQGTEKTPALINDYKEYHTDTTVKFVVRMTEEKLAQAEA-AGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQDILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQRGYESDPVAAWNRAQEKALEEEDRDGNESDSSIDSGSSSGPNFNYILNMPLWCLTKEKVDEL--LKQRDLKKAEL 1172
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453]) HSP 1 Score: 987.252 bits (2551), Expect = 0.000e+0 Identity = 501/1133 (44.22%), Postives = 726/1133 (64.08%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDSQ-----FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKED--AKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRI-FDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + ++I +VP L+KIFDEILVNA+DNK+RD+ M+ IKIN++ + N IS+ N+G GIPVV H E +++P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + Y +KQTW +NM++ E I+ G D+T ITF+PDLT+FKM +LD D +AL RRA+DIA K V + N T++ + F+ YV+LY D D +H +N+ EV +TLS F Q+SFVN I T GG H + +++V L+ E + K + ++P Q+KN +W+FVN ++ NP F+SQ+KE +T F S LLS+KF+ CG+++ I + + K + S K I + KLDDA AG K S CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ Y+K Y +SLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+K Q FYS + W + + W+IKYYKGLGTSTS EAKEYF ++ +HR F YSG DD + + F R++ +RK+W+ ++ R+ + N+ EE ++ K +S++Y DF+NKEL+++SN DN R+IP ++DGLKP QRK+++ C KRN ++VKV QL+GSV+E++ YHH E S+ T++ L P+G FGTR++GGKD+AS RYI T LS + R +FP+ DDN L+ YDDN +EP WY PIIP VL+NG +G+GTGW +PN++ +II N+ +LN P+ M+P Y+ FKG+I E Y +G+ I++S T+E+ ELP+ TQ YKE ++ ML S +++ DY + +TD+ VRF++ + + ++ L ++ L S ++ T+MVLFD +K+Y +IL +FF+ RL Y RK V + AE+ K NQ RFI K G L + N + E +L++ +DSDP+K+W+QA +KE I E+ +K D+ YLL+MP+ TK+K + L +KL E ML +++P Sbjct: 28 SVERIYQKKTQLEHILLRPDTYIGSVEPLSQQMWVFDEDVG-LNCRDITFVPGLYKIFDEILVNAADNKQRDNSMNCIKINIDSENNTISVWNNGKGIPVVEHKVEKVFVPALIFGQLLTSSNYDDDQKKVTGGRNGYGAKLCNIFSTKFTVETACAESKYSFKQTWFDNMSRAGEAKIKPFSGDDYTCITFRPDLTKFKMQSLDRDTVALMTRRAYDIAGASKGVRVLLNGTKLSVNGFRSYVDLYLKDKVDETGTPLTVVHEVVNSRWEVCLTLSEK-GFQQVSFVNSIATTKGGRHTDYVADQIVSKLI---EVVKKRNKGGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKSFGSTCLLSEKFIKQANTCGIVDSIMNWVKFKAQNQLNKKCSAVKHTKIKGVPKLDDANDAGGKHSAGCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKIMGLQYRKNYSDPDSLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSSKNQEFSFYSIPEFTEWKEKQNNIKSWKIKYYKGLGTSTSKEAKEYFSDMARHRIPFRYSGPADDEAITLAFSRKKIEERKDWLTSFMINRRQRREHNLPEEYLYGKETSSLTYHDFVNKELVLFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEISLMMTIVGL--------------PLGQFGTRLHGGKDSASPRYIFTMLSSLSRLLFPSVDDNLLKYNYDDNVKVEPEWYIPIIPLVLVNGGDGIGTGWACKLPNFDVREIINNIHRMLNGDEPLPMLPSYKGFKGTIEELTSNHYLISGEVSIIDSTTIEISELPVKTWTQSYKENVLEVMLNGSDKVPALITDYREYHTDSTVRFVVKMTEERLIEAEAAGLHKVFKLQSPLTCTSMVLFDHVGSLKKYEFVQDILKDFFELRLKYYVLRKAWLVGMLGAESAKLSNQARFILEKIEGTLVIENKPKKELIRMLQEMGYDSDPVKVWKQAQEKEVEIDAGEEDEQKEEQTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKLTELNMLEKKTP 1141
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453]) HSP 1 Score: 986.867 bits (2550), Expect = 0.000e+0 Identity = 501/1133 (44.22%), Postives = 726/1133 (64.08%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDSQ-----FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKED--AKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRI-FDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++E+ YQKKT +EHIL RPD+Y+GS+ + W+FD+ + ++I +VP L+KIFDEILVNA+DNK+RD+ M+ IKIN++ + N IS+ N+G GIPVV H E +++P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + Y +KQTW +NM++ E I+ G D+T ITF+PDLT+FKM +LD D +AL RRA+DIA K V + N T++ + F+ YV+LY D D +H +N+ EV +TLS F Q+SFVN I T GG H + +++V L+ E + K + ++P Q+KN +W+FVN ++ NP F+SQ+KE +T F S LLS+KF+ CG+++ I + + K + S K I + KLDDA AG K S CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ Y+K Y +SLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+K Q FYS + W + + W+IKYYKGLGTSTS EAKEYF ++ +HR F YSG DD + + F R++ +RK+W+ ++ R+ + N+ EE ++ K +S++Y DF+NKEL+++SN DN R+IP ++DGLKP QRK+++ C KRN ++VKV QL+GSV+E++ YHH E S+ T++ L P+G FGTR++GGKD+AS RYI T LS + R +FP+ DDN L+ YDDN +EP WY PIIP VL+NG +G+GTGW +PN++ +II N+ +LN P+ M+P Y+ FKG+I E Y +G+ I++S T+E+ ELP+ TQ YKE ++ ML S +++ DY + +TD+ VRF++ + + ++ L ++ L S ++ T+MVLFD +K+Y +IL +FF+ RL Y RK V + AE+ K NQ RFI K G L + N + E +L++ +DSDP+K+W+QA +KE I E+ +K D+ YLL+MP+ TK+K + L +KL E ML +++P Sbjct: 28 SVERIYQKKTQLEHILLRPDTYIGSVEPLSQQMWVFDEDVG-LNCRDITFVPGLYKIFDEILVNAADNKQRDNSMNCIKINIDSENNTISVWNNGKGIPVVEHKVEKVFVPALIFGQLLTSSNYDDDQKKVTGGRNGYGAKLCNIFSTKFTVETACAESKYSFKQTWFDNMSRAGEAKIKPFSGDDYTCITFRPDLTKFKMQSLDRDTVALMTRRAYDIAGASKGVRVLLNGTKLSVNGFRSYVDLYLKDKVDETGTPLTVVHEVVNSRWEVCLTLSEK-GFQQVSFVNSIATTKGGRHTDYVADQIVSKLI---EVVKKRNKGGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKSFGSTCLLSEKFIKQANTCGIVDSIMNWVKFKAQNQLNKKCSAVKHTKIKGVPKLDDANDAGGKHSAGCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKIMGLQYRKNYSDPDSLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKVSSKNQEFSFYSIPEFTEWKEKQNNIKSWKIKYYKGLGTSTSKEAKEYFSDMARHRIPFRYSGPADDEAITLAFSRKKIEERKDWLTSFMINRRQRREHNLPEEYLYGKETSSLTYHDFVNKELVLFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEISLMMTIVGL--------------PLGQFGTRLHGGKDSASPRYIFTMLSSLSRLLFPSVDDNLLKYNYDDNVKVEPEWYIPIIPLVLVNGGDGIGTGWACKLPNFDVREIINNIHRMLNGDEPLPMLPSYKGFKGTIEELTSNHYLISGEVSIIDSTTIEISELPVKTWTQSYKENVLEVMLNGSDKVPALITDYREYHTDSTVRFVVKMTEERLIEAEAAGLHKVFKLQSPLTCTSMVLFDHVGSLKKYEFVQDILKDFFELRLKYYVLRKAWLVGMLGAESAKLSNQARFILEKIEGTLVIENKPKKELIRMLQEMGYDSDPVKVWKQAQEKEVEIDAGEEDEQKEEQTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKLTELNMLEKKTP 1141
BLAST of DNA topoisomerase 2 vs. Ensembl Sea Lamprey
Match: top2a (DNA topoisomerase II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453]) HSP 1 Score: 730.709 bits (1885), Expect = 0.000e+0 Identity = 373/821 (45.43%), Postives = 533/821 (64.92%), Query Frame = 1 Query: 1135 IKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYK---GLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDE---------DPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 +KN +WIFVN +V NP F+SQ+KE +T KF S LS+KF+ + CG++E I QS +N S +K++ + I KLDDA AG K S +CTLILTEGDSAK+ A+SGL V+G+D++G+F L+GK LN R ++++ N + +++ +G+ YKKKY ESLK+LRYGK+MIM DQD DGSHIKGL++NF HHNWP LLQ F E+FITPI+K K+ Q +PFYS + W T +Y W+IKYYK GLGTSTS EAKEYF ++ +HR F YSG EDD + + F R++ RKEW+ W+ R+ ++ + E ++ K ++Y DFINKELI++SN DN R+IPS++DG KP QRK+++TC KRN ++VKV QL+GSV+E++ YHH E+S+ T++ LAQ++VGSNNIN+L P+G FGTR+ GGKD AS RYI T +S + R +FP DDN L+ +DDNQ +EP WY PIIP VL+NGA+G+GTGW + IPN+NP +II N+R LL+ + P+ M+PWY+NFKGSI+E ++ +G+ IL+S+T+E+ ELP+ TQ YKE ++ ML + ++ DY++ +TDT VRFII + + L+ L ++ L + ++ +MVLFD +K+Y + +IL EF++ RL Y RK+ + AE+ K NQ RFI K G + + N + E +L+ +DSDPI+ W++A K + F+E D + G S D+ Y+LNM + TK++ + L K+ E E L +SP Sbjct: 1 VKNHMWIFVNCLVENPTFDSQTKENMTLQHKKFGSTCSLSEKFIKTAMGCGIVESILNWVKFKAQSQLNQNC----SAKKISKLRGIPKLDDANDAGGKNSQKCTLILTEGDSAKTLAVSGLGVVGRDHYGIFPLRGKMLNVREASYKQIMENAEINNLIKIVGLQYKKKYDDPESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLQHRFLEEFITPIVKVSKNKQELPFYSMPEFDEWKNETSNYKTWKIKYYKDMPGLGTSTSKEAKEYFADMKRHRIEFRYSGPEDDNAITLAFSRKKIEDRKEWLTNWMVDRRQRREQGLPESFLYGKQTAYLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQSLMMTIVSLAQNFVGSNNINVLQPIGQFGTRLNGGKDAASPRYIFTMISTVARLLFPPVDDNLLKFLWDDNQRVEPEWYCPIIPLVLVNGADGIGTGWASRIPNFNPREIINNIRRLLDGEEPLPMLPWYKNFKGSIDELGPNQFMFSGEISILDSETIEISELPVRTWTQTYKESVLEPMLSGTDKTTPLITDYKEYHTDTTVRFIIKISREKLLEAEAAGLHKVFKLQAPLTCNSMVLFDHLGCLKKYESVADILREFYEVRLKYYSLRKEWLNGILGAESAKLSNQARFILEKIEGTVVIENKPKKELIRMLEARGYDSDPIRAWKEAQVKSN--FEEEANSQEDSDDGEESGSATSSTPSSGPDYNYILNMALWCLTKERKDELLRQRDLKIQELEDLKCKSP 815
BLAST of DNA topoisomerase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007762.1 (pep scaffold:Pmarinus_7.0:GL492656:1017:4077:-1 gene:ENSPMAG00000007010.1 transcript:ENSPMAT00000007762.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 318.161 bits (814), Expect = 5.683e-99 Identity = 156/326 (47.85%), Postives = 221/326 (67.79%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYI 1122 ++E+ YQKKT +EHIL RPD+Y+GS+ ++ W+FD+ + +++ YVP LFKIFDEILVNA+DNK+RD M+ IK+ ++ + N+IS+ N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VETS + +KQ W NNM++ + VI+ + G DFT ITF+PDLT+F M LD DI+A+ RRA+DIA K V ++ N ++P+T F++YV+ Y D D +H ++N EV +T+S F Q+SFVN I T GG HV+ V+++ L+ ET+ K++ I Sbjct: 27 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQNMWVFDEGIG-MNCRDVTYVPGLFKIFDEILVNAADNKQRDPNMTCIKVTIDPENNKISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTQFTVETSCSESKKMFKQKWMNNMSKECDSVIKPSSGEDFTCITFQPDLTKFNMTILDKDIMAIMTRRAYDIAGICKGVKVFLNGQKLPLTGFRKYVDFYLKDRVDESGMPLHVVHEVVSNRWEVCLTISEK-GFQQVSFVNSIATTKGGRHVDYVVDQVTSKLI---ETVKKKNKAGI 347
BLAST of DNA topoisomerase 2 vs. Ensembl Yeast
Match: TOP2 (Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant [Source:SGD;Acc:S000005032]) HSP 1 Score: 840.491 bits (2170), Expect = 0.000e+0 Identity = 478/1164 (41.07%), Postives = 695/1164 (59.71%), Query Frame = 1 Query: 181 YQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEK-AQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY----------DNNDS--------QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNN-----ILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLD-FFEQFITPIMKA--FKDTQ-CIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFH-YSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSK--SIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIK-------------------DAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIF---EESYD-FGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504 YQK + +EHIL RPD+Y+GS+ + QWI+D+ + +IEK + VP LFKIFDEILVNA+DNK RD M I +N++ +E+ I + NDG GIP+ +H+ EN+YIP +IFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F +ET+ G +Y Q W NNM+ P I +GP +T +TFKPDLTRF M LD DI+ + RR +DI +++++++Y N + I +FK YVELY DN + ++ INN EVA +S SF QISFVN I T GG HVN +++V+ + + + K+ K QIKN+++IF+N ++ NP F SQ+KE LT+ F S+ + +++N I+ L R+ + + ++ +L+K + I + KL+DA AGTK +CTL+LTEGDSA S A++GL V+G+DY+G + L+GK LN R ++L N + + + +G+ ++KKY E KSLRYG +MIM DQD DGSHIKGLI+NF ++P LL + F +FITPI+K K T+ I FY+ Y+ W + W+ KYYKGLGTS + E +EYF N+D+H K FH G++ DY+ + F ++++ RKEW+ Q+ + +L + E I DFINKELI++S DN+R+IP+++DG KP QRK++Y C K+N ++KV QL+ VSE T YHH E+S+ T+I LAQ++VGSNNI LL+P G FGTR GGKD A+ARYI T+L+ + R IF ADD + +D +T+EP WY PI+P +L+NGA G+GTGW T+IP +NP +II+N+R L+ND+ QM PW+R + G+I E + +Y+ G+ + LE+ ELP T KEY++ + N K ++D E+++ D ++FII L + K ++ + L S IS NMV FD H +IK+Y++ EIL EF+ RL Y+KRKDH +++ E +K Q++FIK + L FN+ N ++ I + A E + + EE Y + YLL M + S TK++ + L + K E E L + S + Sbjct: 12 YQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLKSLEKKRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVS-DISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKKKKKKSVKSF---QIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEE--NALKKSDGTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKKY---EDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYI-DLAFSKKKADDRKEWLRQY--EPGTVLDPTLKE----------IPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDN-IKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAK 1152
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO44813 (DNA topoisomerase 2 [Source:UniProtKB/TrEMBL;Acc:A7RUU5]) HSP 1 Score: 434.876 bits (1117), Expect = 5.994e-140 Identity = 225/486 (46.30%), Postives = 319/486 (65.64%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEK-AQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQ-------------FIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK---YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKM 1560 ++E+ Y KKT +EHIL RPD+Y+GS+ + ++ +++D I+ +EI YVP LFKIFDEILVNA+DNK+RD MS IKI +N ++N IS+ NDG GIP+ +H +Y+PT+IFG LLTSSNY+D +K TGGRNG+GAKLCN+FSK FSVET+ R+KQ WTNNM + EPVI++ ++T ITF+PDL +FKM+ LD D +AL RRA+DIA++++ VS+ N ++ + +FK YV+L ++ +H +NN EV VT+S F Q SFVN I T GG HVN +++V L+ T++K+ K I+P QIK+ LW+F+N ++ NP F+SQ+KE +T F S+ LSDKF+ + + G++E + + M K+ + S K + I I KLDDA AG K S CTLILTEGDSAK+ A+SGL ++G+D +GVF L+GK LN R +++ Sbjct: 36 SVERIYTKKTQLEHILLRPDTYIGSVEPNKQNMFVYDDILEAIVNREITYVPGLFKIFDEILVNAADNKQRDPAMSTIKIEINPEKNFISVWNDGRGIPIEMHKEHQVYVPTMIFGQLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSKKFSVETACLENKKRFKQVWTNNMGKAAEPVIKEFTSNKEYTCITFQPDLEKFKMETLDRDTVALLTRRAYDIAASVRGVSVILNGKKLKVKTFKDYVQLCLKGATKDKEEDDEEEKKPTVVHEVVNNRWEVCVTVSDK-GFQQASFVNSIATTKGGTHVNYVTDQIVDKLM----TVIKKKNKGGLAIKPFQIKSHLWVFINCLIENPAFDSQTKENMTLRAKDFGSKCELSDKFIKAVQNSGVMENVMNWMRFKEKAQLNKKCSGSKHSKIRGIPKLDDANDAGGKNSRHCTLILTEGDSAKTLAISGLSIVGRDRYGVFPLRGKLLNVREASHKQV 516
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO44811 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUU3]) HSP 1 Score: 232.261 bits (591), Expect = 2.406e-67 Identity = 132/353 (37.39%), Postives = 204/353 (57.79%), Query Frame = 1 Query: 2485 LSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSI---VRDYEDRNTDTEVRFIIHLKLD-LKEI-RLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY------DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504 LS + + +FP +D+ L+ +DNQ IEP WY PIIP +L+NGA G+GTG+ T +PNY+P I EN+R ++N + P +M+PWY+NF G+I + D KY TG +++ TLE+ ELPIG TQ YKE ++ ML + + + DY++ +T+T VRF+I + + ++E ++ L + L + I+T+NMVLFD +K+Y T EIL EFF R+ Y RK + + AE+ K +Q RFI K G + + N + + +L Q + SDP+K W+ + + D D + DF YLLNM + S +++K + L K E E L ++SP+ Sbjct: 2 LSTVSKMLFPPSDEPNLKFLNEDNQRIEPEWYCPIIPTILVNGAEGIGTGYSTKVPNYDPRAIAENIRKMMNGEEPEEMLPWYKNFIGTITKVDDTKYSVTGNIEVIDDTTLEITELPIGTWTQSYKESVLEPMLHGTDKVPPCITDYKEYHTETRVRFVITMAENKMREAEQVGLHKKFKLEATINTSNMVLFDAMGCLKKYDTTREILKEFFTLRMERYIMRKAYMEGMLTAESGKLNSQARFILEKIEGTIVIENKPKRDLITMLVQRGYPSDPVKAWKDSQDTTLGVDDSDDDTMSTVSSTASGAGGPDFNYLLNMSMWSLSQEKKDELLKQRDQKAAELEDLRKKSPK 354
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO29547 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T3B9]) HSP 1 Score: 177.948 bits (450), Expect = 2.746e-51 Identity = 78/166 (46.99%), Postives = 121/166 (72.89%), Query Frame = 1 Query: 1843 QNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSE 2340 + W T ++ W++KYYKGLGTST EAKEYF ++++H+ +F Y G DD + M F +++ +RK+W+ + L++RK ++ + E ++ K+ +SY DF+NKELI++SN DN R+IPS++DGLKP QRK+++TC KRN ++VKV QL+GS++EL+ YHH E Sbjct: 2 EEWKAGTANHKSWKVKYYKGLGTSTPKEAKEYFSDMERHKINFKYEGPHDDEAIVMAFSKKKIQERKDWLTRGLEERKWRREQGLSELYLYEKDTKRVSYCDFVNKELILFSNTDNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLAGSIAELSAYHHGE 167
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO44812 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUU4]) HSP 1 Score: 127.102 bits (318), Expect = 2.375e-34 Identity = 58/114 (50.88%), Postives = 77/114 (67.54%), Query Frame = 1 Query: 1561 LMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKG 1902 L N + +++ G+ Y KKY +++ LKSLRYG +MIM DQD DGSHIKGL++NF H NWP LL+L F EQFITPI+K K + FYS Y+ W ++ W++KYYKG Sbjct: 1 LDNAEINNIIKITGLQYNKKYKSEDDLKSLRYGHLMIMTDQDQDGSHIKGLVINFIHSNWPGLLKLGFVEQFITPIVKVSKGKEEHSFYSIPEYEEWKAGNANHKSWKVKYYKG 114
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Match: EDO25698 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DVR1]) HSP 1 Score: 76.2554 bits (186), Expect = 5.147e-15 Identity = 54/166 (32.53%), Postives = 83/166 (50.00%), Query Frame = 1 Query: 1414 GECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKE-SLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLG 1908 +C + L EGDSA A G D +++ + L+GK LN + K+ N++ K++ +LG+S + + +L +RY KV+IM D D DGSHI LIL FF E+++ + TP + K Q Y+ + Q + A I+ YKGLG Sbjct: 61 AQCEIFLVEGDSAGGTAKQGRD---RNFQAILPLRGKILNVEKAMQHKVFENEEIKNMFTALGVSIGTEEDPRALNLSKVRYHKVVIMCDADVDGSHIATLILTFFFRYMREMIEQGYV-YIATPPLYLVKKGQKRE-YAWDDNQRDLIAQKMGGGVTIQRYKGLG 221
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2b (DNA topoisomerase II beta [Source:NCBI gene;Acc:101157229]) HSP 1 Score: 1055.05 bits (2727), Expect = 0.000e+0 Identity = 523/1123 (46.57%), Postives = 754/1123 (67.14%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDS--QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENL 3444 ++E+ YQKKT +EHIL RPD+YVGS+ + W+FD+ + ++EI YVP L+KIFDEILVNA+DNK+RD MS IKI ++ + N I+I N+G GIPVV H E MY+P LIFG+LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW NNMT+ +EP I G DFT +TF+PDL +FKM+ LD D +AL RRA+D+A + + V + N ++P+ F+ YV+LY D + ++ +N+ EV +T+S F QISFVN I T GG H++ V+++V ++ E + K++ ++P Q+KN +W+FVN+++ NP F+SQ+KE +T F S+ +LS+KF+ +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F EQFITPI+KA K+ Q + FYS ++ W K T +Y W +KYYKGLGTSTS EAKEYF ++++HR +F Y G+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNNIN+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +LN + P+ M+P Y+NFKG I+E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TD+ V+F++ + KL E + L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL + RKD + + AEA K NQ RF+ K GK+++ N ++ E +L Q ++SDP+ W +A +K + D + +S +F Y+LNMP+ TK+K+E L Sbjct: 39 SVERVYQKKTPLEHILLRPDTYVGSVEPVSQPMWVFDEDVG-MNQREITYVPGLYKIFDEILVNAADNKQRDKNMSAIKITIDPESNTITIWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYRHSFKQTWQNNMTKTSEPKIRFFDGDDFTCVTFQPDLAKFKMEKLDRDTVALMTRRAYDVAGSCRGVKVTLNGKKLPVNGFRSYVDLYVKEKLDETGVPLKVVNEMVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKII---EVVKKKNKAGVTVKPFQVKNHIWVFVNALIENPTFDSQTKENMTLQTKSFGSKCVLSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEQFITPIVKATKNKQELSFYSLPEFEEWKKQTDNYKSWHVKYYKGLGTSTSKEAKEYFADMERHRITFRYQGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEKYLYGTQTKHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINILQPLGQFGTRINGGKDAASPRYIFTMLSPLTKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVLDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALINDYKEYHTDSTVKFVVRMSEEKLAQAEA-VGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEAAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQKGYESDPVAAWSKAQEKAQEEGETDGNQSDSSVDSGSSSGPNFNYILNMPLWCLTKEKVEEL 1151
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2a (DNA topoisomerase II alpha [Source:NCBI gene;Acc:101158729]) HSP 1 Score: 1018.84 bits (2633), Expect = 0.000e+0 Identity = 516/1161 (44.44%), Postives = 751/1161 (64.69%), Query Frame = 1 Query: 112 IRCKYSNLP--TTTKSLILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNS---KSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIF-----EESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 ++ Y N P T K ++E+ YQKKT +EHIL RPDSY+GS+ + W++D + +++ +VP L+KIFDEILVNA+DNK+RD MS IK+N++ + N IS+ N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW +NM + + I+ G +FT ITFKPDL++FKM LD D +AL RRA+D+A + K V ++FN ++PIT F+ YV++Y D D IH +N EV +T+S F Q+SFVN I T GG H++ +++V L+ E + K++ ++P Q+KN +W+FVN +V NP F+SQ+KE +T F S LSDKF CG++E I Q+ +N K S K I + KLDDA AG K S CTLILTEGDSAK+ A+SGL V+G+D +GVF L+GK LN R ++++ N + +V+ LG+ YKK Y ESLKSLRYGK+MIM DQD DGSHIKGL++NF HHNWP LL+ +F E+FITPI+KA + FYS + W + ++ W+IKYYKGLGTSTS EAKEYF ++++HR F YSG EDD + + F +++ +RKEW+ ++ R+ + N+ E+ ++ ++ S+SY DFINKEL+++SN DN R+IP ++DG KP QRK+++ C KRN ++VKV QL+GSV+E++ YHH E S+ T++ LAQ++VGSNN+NLL P+G FGTR++GGKD+AS RYI T LSP+ R +FP DDN L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW + IPNY+ +I+ N+ +L+ + P+ M+P Y+ F+G+I++ +Y +G+ I++S T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TD VRF++ + + ++ L ++ L S ++ +MVLFD +K+Y + +IL +FF R+ Y RK+ V + AE+ K NQ RFI K G L + N + E +L++ +DSDP++ W++A KK+ + + ++ D+ YLL+MP+ TK+K E+L +K+ E L +SP Sbjct: 5 LKALYENKPLEKTKKDSKRLSVERIYQKKTQLEHILLRPDSYIGSVEPVTQQMWVYDVDVG-LNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVNIDVENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDEQKKVTGGRNGYGAKLCNIFSTKFTVETACKESRKTFKQTWYDNMGRAGDTNIKAFDGEEFTCITFKPDLSKFKMSTLDKDTVALMTRRAYDVAGSSKGVKVFFNGKRLPITGFRSYVDMYVKDKVDELGGPLTVIHEAVNERWEVCLTMSEK-GFQQVSFVNSIATTKGGRHIDYVADQIVGRLI---EVVKKKNKAGVAVKPFQVKNHMWLFVNCLVENPTFDSQTKENMTLQQKSFGSTCSLSDKFFKQATSCGIVESIMNWVKFKAQTQLNKKC----SAVKHTKIKGVPKLDDANDAGGKNSIGCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNVIKILGLQYKKNYSDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKNQLSFYSIPEFNAWKETQSNHKSWKIKYYKGLGTSTSQEAKEYFSDMERHRIPFKYSGPEDDEAISLAFSKKKVEERKEWLTNFMVNRRQRREHNLPEDYLYGQSTKSLSYNDFINKELVLFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSPLARLVFPPVDDNLLKYNYDDNQRVEPEWYIPIIPTVLVNGAEGIGTGWASKIPNYDIREIVSNIHRMLDGEEPLPMLPNYKGFRGTIDQVMSNQYMNSGEVAIIDSTTIEISELPVKTWTQAYKENVLEPMLNGTDKVPALITDYKEYHTDATVRFVVKMTEEKLMEAEAAGLHKVFKLQSPLTCNSMVLFDYAGSLKKYESVQDILKDFFDLRMKYYVLRKEWLVGMLGAESSKLSNQARFILEKIQGTLVIENKPKKELIRMLQEMGYDSDPVRAWKEAQKKDEDDMEAEEEQEEGAEREDQSSGADYNYLLSMPMWFLTKEKKEDLCKQRDAKMTELNTLKGKSP 1156
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2b (DNA topoisomerase II beta [Source:NCBI gene;Acc:101157229]) HSP 1 Score: 858.981 bits (2218), Expect = 0.000e+0 Identity = 429/959 (44.73%), Postives = 631/959 (65.80%), Query Frame = 1 Query: 658 QTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY--DNNDS-----QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAK--YIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERI--------QSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENL 3444 QTW NNMT+ +EP I G DFT +TF+PDL +FKM+ LD D +AL RRA+D+A + + V + N ++P+ F+ YV+LY + D + ++ +N+ EV +T+S F QISFVN I T GG H++ V+++V ++ E + K++ ++P Q+KN +W+FVN+++ NP F+SQ+KE +T F S+ +LS+KF+ +CG++E I Q+ +N K S K + I I KLDDA AG K S ECTLILTEGDSAKS A+SGL V+G+D +GVF L+GK LN R ++++ N + +++ +G+ YKK Y ESL+SLRYGK+MIM DQD DGSHIKGL++NFFHHNWP LL+ F EQFITPI+KA K+ Q + FYS ++ W K T +Y W +KYYKGLGTSTS EAKEYF ++++HR +F Y G+EDD + + F ++++ RKEW+ +++ R+ + E+ ++ +SY DFINKELI++SN DN R+IPS++DGLKP QRK+++TCLKRN ++VKV QL+GSV+E++ YHH E+++ T+++LAQ++VGSNNIN+L P+G FGTR+ GGKD AS RYI T LSP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +LN + P+ M+P Y+NFKG I+E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TD+ V+F++ + KL E + L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL + RKD + + AEA K NQ RF+ K GK+++ N ++ E +L Q ++SDP+ W +A +K + D + +S +F Y+LNMP+ TK+K+E L Sbjct: 123 QTWQNNMTKTSEPKIRFFDGDDFTCVTFQPDLAKFKMEKLDRDTVALMTRRAYDVAGSCRGVKVTLNGKKLPVNGFRSYVDLYVKEKLDETGVPLKVVNEMVNDRWEVCLTMSEK-GFQQISFVNSIATTKGGRHIDYVVDQIVAKII---EVVKKKNKAGVTVKPFQVKNHIWVFVNALIENPTFDSQTKENMTLQTKSFGSKCVLSEKFIRAATNCGIVESILNWVKFKAQTQLNKKC----SSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKIVGLQYKKSYDDPESLRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEQFITPIVKATKNKQELSFYSLPEFEEWKKQTDNYKSWHVKYYKGLGTSTSKEAKEYFADMERHRITFRYQGAEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEKYLYGTQTKHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINILQPLGQFGTRINGGKDAASPRYIFTMLSPLTKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVLDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALINDYKEYHTDSTVKFVVRMSEEKLAQAEA-VGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEAAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQKGYESDPVAAWSKAQEKAQEEGETDGNQSDSSVDSGSSSGPNFNYILNMPLWCLTKEKVEEL 1072
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2b (DNA topoisomerase II beta [Source:NCBI gene;Acc:101157229]) HSP 1 Score: 245.743 bits (626), Expect = 7.727e-72 Identity = 130/332 (39.16%), Postives = 202/332 (60.84%), Query Frame = 1 Query: 2488 SPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN---SKSIVRDYEDRNTDTEVRFIIHL---KLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----DFGYLLNMPVRSFTKDKIENL 3444 SP+ + +FPA D N L+ YDDNQ +EP WY PIIP VL+NGA G+GTGW IPNY+P +I+ N+ +LN + P+ M+P Y+NFKG I+E Q +Y +G+ +L+ T+E+ ELP+ TQ YKE ++ ML + +++ DY++ +TD+ V+F++ + KL E + L ++ L S ++ +MVLFD +KRY + +IL EFF+ RL + RKD + + AEA K NQ RF+ K GK+++ N ++ E +L Q ++SDP+ W +A +K + D + +S +F Y+LNMP+ TK+K+E L Sbjct: 5 SPLTKLLFPAVDSNLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGVIHELGQNQYLVSGEVSVLDKNTIEITELPVRTWTQAYKESVLEPMLQGTDKTPALINDYKEYHTDSTVKFVVRMSEEKLAQAE-AVGLHKVFKLQSSLTCNSMVLFDHMGCLKRYDSVQDILKEFFELRLHYCKLRKDWLLGSLGAEAAKLSNQARFVLEKIEGKISIENKSKRELIRMLVQKGYESDPVAAWSKAQEKAQEEGETDGNQSDSSVDSGSSSGPNFNYILNMPLWCLTKEKVEEL 335
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Match: top2a (DNA topoisomerase II alpha [Source:NCBI gene;Acc:101158729]) HSP 1 Score: 226.868 bits (577), Expect = 3.925e-67 Identity = 105/196 (53.57%), Postives = 143/196 (72.96%), Query Frame = 1 Query: 166 NIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDL 753 ++E+ YQKKT +EHIL RPDSY+GS+ + W++D + +++ +VP L+KIFDEILVNA+DNK+RD MS IK+N++ + N IS+ N+G GIPVV H E +Y+P LIFG LLTSSNYDD +K TGGRNG+GAKLCN+FS F+VET+ + + +KQTW +NM + + I+ G +FT ITFKPDL Sbjct: 19 SVERIYQKKTQLEHILLRPDSYIGSVEPVTQQMWVYDVDVG-LNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVNIDVENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDEQKKVTGGRNGYGAKLCNIFSTKFTVETACKESRKTFKQTWYDNMGRAGDTNIKAFDGEEFTCITFKPDL 213
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000064303.1 (SMESG000064303.1) HSP 1 Score: 2056.18 bits (5326), Expect = 0.000e+0 Identity = 1041/1089 (95.59%), Postives = 1047/1089 (96.14%), Query Frame = 1 Query: 310 MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPRXXXXXXXXXXXXXXKNLYADTELQ 3576 MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSI K I E+ S D+ N +K+ T+LSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVL+NGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQ LKKEHRIFDEDPVKKGI EESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPREIWLEELQILEEKIKNLYADTELQ Sbjct: 1 MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELYDNNDSQFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKKDFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSIIIK--IMCEIFHRSWTDS-------------------------NHLKEKLFTRLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLVNGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVNSKSIVRDYEDRNTDTEVRFIIHLKLDLKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFIKDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQTLKKEHRIFDEDPVKKGILEESYDFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPREIWLEELQILEEKIKNLYADTELQ 1062
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037565.1 (SMESG000037565.1) HSP 1 Score: 1004.59 bits (2596), Expect = 0.000e+0 Identity = 521/1138 (45.78%), Postives = 736/1138 (64.67%), Query Frame = 1 Query: 163 ENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDSQF--IHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPN--QIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY--DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504 E+IEK Y KKT +EHIL RPDSYVGSI K+ WIFD +N ++EK I Y P L+KI+DEILVNASDNK RD +MS I+I++N +N I I N+G GIPVV+H N+++PT+IFG LLTS+N++D ++ TGGRNG+GAKLCN+FS F +ETS++ G +KQTWT NM ++P+I Q DFT +TF PDL RF M +LD + IALF RRA+DIA+ + +Y N QIP+ +FK YVELY D+N+ + I+ + EVA+T S + +F Q+SFVN I T GG HVN ++ L++ + +K D + ++ Q+K ++W+FV ++ NP F+SQ+KE +T F S L+DKF++ + CG++E+I +M M K D S K + DI KLDDA AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R +++ N + +++ +G+ Y +KY ESLK+LRYGK+MIM DQD DGSHIKGL++NF H WP LL+ +F EQFITPI+KAFK+ Q + FYS W + TPD +KWR+KYYKGLGTSTS EAKEYF ++++H F YSG ED + + F + ++ +RKEW+ W++ K + +DE ++ K I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+ T+I+LAQD+VGSNNINLL+P G FGTR+ GGKD+AS RYI T+L WYAPIIP VLING +G+GTGW + IPN+NP +I+NL+ ++N P++M PWYRNF G+I E + KY G+ L+ TLE+ ELPI + T YKE ++ E+ + + + + DY++ NTD VRF++ + + + L + ++ +NM+LFDE I++Y+ +EIL FFK RL IY KRK++ + + A+A K +NQ RFI K GK+ N L +DSDP+K W+++++K I + + E+S DFGYL M + + T +K + L KL E +++ +SP+ Sbjct: 13 ESIEKRYLKKTQLEHILLRPDSYVGSIKPEEKALWIFDSEKNCMVEKRITYNPGLYKIYDEILVNASDNKIRDRKMSCIRIDINGPKNMIRIWNNGKGIPVVMHKDVNVHVPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSNEFILETSNKEYGKSFKQTWTKNMGVASDPIISSCQKEDFTCVTFYPDLKRFNMSHLDDETIALFSRRAYDIAACTNGIVVYLNGQQIPVKNFKDYVELYTKNCLDSNEEELKVIYEKFGDRWEVAMTTSLNDNFCQVSFVNSIATTKGGTHVNHITDQAAVKLLEIAKKKIKSDKQAVKLKVAQVKMNMWVFVKCLIENPSFDSQTKENMTLNAKDFGSTCALTDKFISQVAKCGIVEKI-TMWAMFKNQALLDKKCSKTKHTKLKDIPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLRGKLLNVREAGVKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQRNTPDSNKWRLKYYKGLGTSTSKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASLMSTIINLAQDFVGSNNINLLMPNGQFGTRLAGGKDSASPRYICTQLK----------------------------WYAPIIPMVLINGCDGIGTGWSSKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGKVICENVKIAVLIDKLVAAKYDSDPVKAWQKSVEKLLAIDKGEEENQEDIEDSNKPDFGYLTQMQILTLTAEKKDALLKERDEKLKELDIIRNKSPQ 1120
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037559.1 (SMESG000037559.1) HSP 1 Score: 985.712 bits (2547), Expect = 0.000e+0 Identity = 516/1148 (44.95%), Postives = 738/1148 (64.29%), Query Frame = 1 Query: 157 ILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDS--QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKE--DAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----------DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 + E+IEK YQKKT +EHIL RPDSYVGSI K K W+FD +N+++EK+I Y PAL+KIFDEILVNASDNK RD +M+ I+I+++ N + I N+G GIPV +H +YIPT+IFG LLTS+N++D ++ TGGRNG+GAKLCN+FS F +ETSS+ G +KQTW+NNM +P I KA DFT +TF PDL RF M LD DI+ALF RRA+DIA+ + ++++ N QI + +FK YV+LY D N+ + ++ + EVAVT S + +F+Q+SFVN I T GG HVN ++L +++K + +K+ A ++P Q+K ++WIFV ++ NP F+SQ+KE +T F S+ L++KF++ + CG++E++ +M + K D S K + D+ KLDDA AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R +++ N + +++ +G+ Y +KY ESLK+LRYGK+MIM DQD DGSHIKGL++NF H WP LL+ +F EQFITPI+KAFK+ Q + FYS W K TP ++WR+KYYKGLGTST EAKEYF ++++H F YSG ED + + F + ++ +RKEW+ W++ K + +DE ++ K I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+ T+I+LAQD+VGSNNINLL+P G FGTR+ G K A ++ T +++++ DDNQ+IEP WYAPIIP VLING +G+GTGW + IPN+NP +I+NL+ ++N P++M PWYRNF G+I E + KY G+ L+ TLE+ ELPI + T YKE ++ E+ + + + + DY++ NTD VRF++ + + + L + ++ +NM+LFDE I++Y+ +EIL FFK RL IY KRK++ + + A+A K +NQ RFI K G + N L +DSDP+K W + F+ + + E+ DFGYL M + + T +K E L KL E + +SP Sbjct: 14 VPEDIEKLYQKKTQLEHILLRPDSYVGSIKKEDKLMWVFDDEKNEMVEKKITYNPALYKIFDEILVNASDNKIRDSKMTTIRIDIDSKMNMVRIWNNGRGIPVTIHKEHQVYIPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSSEFVLETSSKEYGKSFKQTWSNNMNDCFDPEISKAAKEDFTCVTFYPDLKRFSMTRLDEDIVALFSRRAYDIAACTQGITVFLNGKQINVKTFKDYVDLYTKHVLDANEEPLKVVYESYGKRWEVAVTTSVNETFSQVSFVNSIATTKGGTHVNYLADQLAAKILEKAKKKIKDDKQAVKLKPAQVKMNMWIFVRCLIENPSFDSQTKENMTLNQKDFGSECTLNEKFISLVAKCGIVEKL-TMWTLFKNQALLDKKCSKTKQTKLKDMPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLKGKLLNVREASAKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQKVTPGANQWRLKYYKGLGTSTDKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASLMSTIINLAQDFVGSNNINLLMPNGQFGTRLAGAK---IALHLVT--YAVLKYLL------------DDNQSIEPEWYAPIIPMVLINGCDGIGTGWSSKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGIIICENVKIAVLIDKLVAAKYDSDPVKAWMK--------FNANKLTIEKAEDEEDEEAIEDSGKPDFGYLTQMQILTLTAEKKEALLKERDEKLEELMRIKNKSP 1134
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037565.1 (SMESG000037565.1) HSP 1 Score: 979.548 bits (2531), Expect = 0.000e+0 Identity = 512/1138 (44.99%), Postives = 735/1138 (64.59%), Query Frame = 1 Query: 163 ENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDSQF--IHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKEDAKYIRPN--QIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY--DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSPR 3504 E+IEK Y KKT +EHIL RPDSYVGSI K+ WIFD +N ++EK I Y P L+KI+DEILVNASDNK RD +MS I+I++N +N I I N+G GIPVV+H N+++PT+IFG LLTS+N++D ++ TGGRNG+GAKLCN+FS F +ETS++ G +KQTWT NM ++P+I Q DFT +TF PDL RF M +LD + IALF RRA+DIA+ + +Y N QIP+ +FK YVELY D+N+ + I+ + EVA+T S + +F Q+SFVN I T GG HVN ++ L++ + +K D + ++ Q+K ++W+FV ++ NP F+SQ+KE +T F S L+DKF++ + CG++E+I +M M K D S K + DI KLDDA AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R +++ N + +++ +G+ Y +KY ESLK+LRYGK+MIM DQD DGSHIKGL++NF H WP LL+ +F EQFITPI+KAFK+ Q + FYS W + TPD +KWR+KYYKGLGTSTS EAKEYF ++++H F YSG ED + + F + ++ +RKEW+ W++ K + +DE ++ K I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+ T+I+LAQD+VGSNNINLL+P G FGTR+ GGKD+AS RYI T+LS + + IF +DD ++ W + ++ NG+ ++ IPN+NP +I+NL+ ++N P++M PWYRNF G+I E + KY G+ L+ TLE+ ELPI + T YKE ++ E+ + + + + DY++ NTD VRF++ + + + L + ++ +NM+LFDE I++Y+ +EIL FFK RL IY KRK++ + + A+A K +NQ RFI K GK+ N L +DSDP+K W+++++K I + + E+S DFGYL M + + T +K + L KL E +++ +SP+ Sbjct: 13 ESIEKRYLKKTQLEHILLRPDSYVGSIKPEEKALWIFDSEKNCMVEKRITYNPGLYKIYDEILVNASDNKIRDRKMSCIRIDINGPKNMIRIWNNGKGIPVVMHKDVNVHVPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSNEFILETSNKEYGKSFKQTWTKNMGVASDPIISSCQKEDFTCVTFYPDLKRFNMSHLDDETIALFSRRAYDIAACTNGIVVYLNGQQIPVKNFKDYVELYTKNCLDSNEEELKVIYEKFGDRWEVAMTTSLNDNFCQVSFVNSIATTKGGTHVNHITDQAAVKLLEIAKKKIKSDKQAVKLKVAQVKMNMWVFVKCLIENPSFDSQTKENMTLNAKDFGSTCALTDKFISQVAKCGIVEKI-TMWAMFKNQALLDKKCSKTKHTKLKDIPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLRGKLLNVREAGVKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQRNTPDSNKWRLKYYKGLGTSTSKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASLMSTIINLAQDFVGSNNINLLMPNGQFGTRLAGGKDSASPRYICTQLSKLTKLIF----------HHDDEAVLKICWMT-----INLSNQNGMHQLFRCKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGKVICENVKIAVLIDKLVAAKYDSDPVKAWQKSVEKLLAIDKGEEENQEDIEDSNKPDFGYLTQMQILTLTAEKKDALLKERDEKLKELDIIRNKSPQ 1133
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Match: SMESG000037559.1 (SMESG000037559.1) HSP 1 Score: 958.362 bits (2476), Expect = 0.000e+0 Identity = 506/1148 (44.08%), Postives = 722/1148 (62.89%), Query Frame = 1 Query: 157 ILENIEKTYQKKTLIEHILHRPDSYVGSINKSIKSQWIFDKSQNKIIEKEIMYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIPVVLHSTENMYIPTLIFGNLLTSSNYDDSLEKFTGGRNGFGAKLCNLFSKSFSVETSSEITGYRYKQTWTNNMTQFTEPVIEKAQGPDFTTITFKPDLTRFKMDNLDTDIIALFHRRAFDIASNLKNVSIYFNDTQIPITSFKQYVELY-----DNNDS--QFIHNTINNSLEVAVTLSTSYSFTQISFVNGINTVNGGLHVNSFVNKLVQVLVQKFETIMKE--DAKYIRPNQIKNSLWIFVNSVVSNPCFESQSKEYLTSLPNKFSSQILLSDKFVNNIIDCGLLERIQSMMNMKK-----DFPKSLRKVNNILDIVKLDDALHAGTKLSGECTLILTEGDSAKSFAMSGLDVLGKDYFGVFSLQGKNLNTRNVKERKMLMNKQYKDVVVSLGISYKKKYLTKESLKSLRYGKVMIMADQDPDGSHIKGLILNFFHHNWPELLQLDFFEQFITPIMKAFKDTQCIPFYSHNAYQNWVKATPDYSKWRIKYYKGLGTSTSAEAKEYFRNIDQHRKSFHYSGSEDDYLMKMVFEREQSTKRKEWILQWLKKRKGLLKKNIDEENIFVKNKTSISYKDFINKELIVYSNQDNVRNIPSIMDGLKPSQRKIIYTCLKRNFIKDVKVTQLSGSVSELTNYHHSEKSIYDTVIHLAQDYVGSNNINLLVPVGHFGTRVYGGKDNASARYISTKLSPIVRFIFPAADDNFLQCKYDDNQTIEPIWYAPIIPFVLINGANGLGTGWKTFIPNYNPFQIIENLRLLLNDKPPIQMVPWYRNFKGSINESDQKKYKTTGKFRILNSKTLEVYELPIGISTQKYKEYIVNEMLVN----SKSIVRDYEDRNTDTEVRFIIHLKLD--LKEIRLNLDQLLNLSSEISTTNMVLFDEHSEIKRYSTPVEILVEFFKARLIIYEKRKDHFVQKILAEAKKSENQLRFI--KDAGKLNLRNFNEHEANLLLKQNSFDSDPIKIWEQALKKEHRIFDEDPVKKGIFEESY-----------DFGYLLNMPVRSFTKDKIENLNNLFKSKLLEAEMLNRRSP 3501 + E+IEK YQKKT +EHIL RPDSYVGSI K K W+FD +N+++EK+I Y PAL+KIFDEILVNASDNK RD +M+ I+I+++ N + I N+G GIPV +H +YIPT+IFG LLTS+N++D ++ TGGRNG+GAKLCN+FS F +ETSS+ G +KQTW+NNM +P I KA DFT +TF PDL RF M LD DI+ALF RRA+DIA+ + ++++ N QI + +FK YV+LY D N+ + ++ + EVAVT S + +F+Q+SFVN I T GG HVN ++L +++K + +K+ A ++P Q+K ++WIFV ++ NP F+SQ+KE +T F S+ L++KF++ + CG++E++ +M + K D S K + D+ KLDDA AGTK S +CTLILTEGDSAKS A+SGL V+G+DY+GVF L+GK LN R +++ N + +++ +G+ Y +KY ESLK+LRYGK+MIM DQD DGSHIKGL++NF H WP LL+ +F EQFITPI+KAFK+ Q + FYS W K TP ++WR+KYYKGLGTST EAKEYF ++++H F YSG ED + + F + ++ +RKEW+ W++ K + +DE ++ K I++++FIN+ELI++SN DN R+IP +MDG KP QRK+++ CLKRN +K++KV QL+GSV+EL+ YHH E S+ GKD+AS RYI T+LS + + IF D+ L+ DDNQ+IEP WYAPIIP VLING +G+GTGW + IPN+NP +I+NL+ ++N P++M PWYRNF G+I E + KY G+ L+ TLE+ ELPI + T YKE ++ E+ + + + + DY++ NTD VRF++ + + + L + ++ +NM+LFDE I++Y+ +EIL FFK RL IY KRK++ + + A+A K +NQ RFI K G + N L +DSDP+K W + F+ + + E+ DFGYL M + + T +K E L KL E + +SP Sbjct: 14 VPEDIEKLYQKKTQLEHILLRPDSYVGSIKKEDKLMWVFDDEKNEMVEKKITYNPALYKIFDEILVNASDNKIRDSKMTTIRIDIDSKMNMVRIWNNGRGIPVTIHKEHQVYIPTMIFGQLLTSTNFNDDKKQVTGGRNGYGAKLCNIFSSEFVLETSSKEYGKSFKQTWSNNMNDCFDPEISKAAKEDFTCVTFYPDLKRFSMTRLDEDIVALFSRRAYDIAACTQGITVFLNGKQINVKTFKDYVDLYTKHVLDANEEPLKVVYESYGKRWEVAVTTSVNETFSQVSFVNSIATTKGGTHVNYLADQLAAKILEKAKKKIKDDKQAVKLKPAQVKMNMWIFVRCLIENPSFDSQTKENMTLNQKDFGSECTLNEKFISLVAKCGIVEKL-TMWTLFKNQALLDKKCSKTKQTKLKDMPKLDDANFAGTKNSLQCTLILTEGDSAKSLAVSGLAVIGRDYYGVFPLKGKLLNVREASAKQLTENAEITNIIKIIGLQYSQKYELPESLKTLRYGKLMIMTDQDQDGSHIKGLLINFIHSKWPNLLKHNFVEQFITPIVKAFKNNQVLSFYSIPELVEWQKVTPGANQWRLKYYKGLGTSTDKEAKEYFSDMERHLIKFRYSGEEDGKSIVLAFSKTKADERKEWLTNWMEDCKRRRELGMDEVYLYGKGTKYITFENFINQELILFSNTDNERSIPCLMDGFKPGQRKVLFACLKRNLVKELKVAQLAGSVAELSAYHHGEASL------------------------------IWGKDSASPRYICTQLSKLTKLIFHHDDEAVLKYLLDDNQSIEPEWYAPIIPMVLINGCDGIGTGWSSKIPNFNPKDVIDNLKRMINGGTPVKMHPWYRNFTGTIVEVCENKYVVNGEINQLDGTTLEITELPIRVWTNSYKESVM-EIYRHGNDKTPAFITDYKEYNTDKTVRFLVEMNPAKYAEAEAAGFHKFFKLQTPLTLSNMILFDECGVIRKYNNGIEILESFFKVRLEIYIKRKNYLLGILSAQASKLQNQARFILEKINGIIICENVKIAVLIDKLVAAKYDSDPVKAWMK--------FNANKLTIEKAEDEEDEEAIEDSGKPDFGYLTQMQILTLTAEKKEALLKERDEKLEELMRIKNKSP 1121 The following BLAST results are available for this feature:
BLAST of DNA topoisomerase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of DNA topoisomerase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of DNA topoisomerase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of DNA topoisomerase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of DNA topoisomerase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of DNA topoisomerase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 3
BLAST of DNA topoisomerase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of DNA topoisomerase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of DNA topoisomerase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of DNA topoisomerase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of DNA topoisomerase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of DNA topoisomerase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of DNA topoisomerase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of DNA topoisomerase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001991 ID=SMED30001991|Name=DNA topoisomerase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=3743bpback to top protein sequence of SMED30001991-orf-1 >SMED30001991-orf-1 ID=SMED30001991-orf-1|Name=SMED30001991-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1090bp MYVPALFKIFDEILVNASDNKRRDDRMSYIKINVNRDENEISISNDGSGIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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